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LongeVC

Venture capitalActively deploying

Washington D.C. · Pre-Seed–Series A · 42 people tracked

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Investment thesis

LongeVC invests in early-stage biotech and longevity companies working toward an ageless future. Its focus areas include pre-clinical and clinical stage drug development companies studying the molecular and cellular mechanisms of aging, early-stage firms building solutions for personalized medicine and advanced diagnostics, and foundational platform technologies and integrated healthcare solutions that enable faster, scalable drug discovery and testing. The firm supports founders by connecting them with a global network of thought leaders and curating an ecosystem of longevity-focused companies.

Source: firm website, verified Aug 17, 2026.

Stage
Pre-Seed–Series A
HQ
Washington D.C., CA, US
Instruments
Equity
Founded
2025
Last 12 months
4 investments
Tracked investments
28

Team · 42 people

from the firm's website & curated & public directories
William Usdin· General Partner
Greg Fishman· Venture Partner
John Mikhael· Advisory Board

Founder mafia

2 people who came through LongeVC went on to found or lead other companies.

What they invest in

from 24 of 28 portfolio companies

Biotech ×20Healthtech ×16AI & Machine Learning ×13Medical Devices ×10Deep Tech ×7Digital Health ×7Longevity ×7Wellness & Fitness ×3

HQs:United States×11Switzerland×2United Kingdom×1

Who they back

founder profiles across 16 portfolio companies
13%
solo founders
2 of 16 mapped founding teams
47%
repeat founders
of 19 founders with career history

Founding team size:solo founder×22 founders×93 founders×24+ founders×3

Where their founders studiedfrom 18 founders with education data

Hyper Island ×2Massachusetts Institute of Technology ×2University of California, Berkeley ×2University of Oxford ×2

What their founders studiedfrom 18 founders with field-of-study data

Engineering ×5Chemistry ×4Life Sciences ×4Business & Management ×3Computer Science ×2Mathematics & Statistics ×2Physics ×2

Where their founders worked beforefrom 19 founders with career history

Parsagen Diagnostics, Inc. ×2

Accelerator rootsportfolio companies that came through a program

Y Combinator ×5

backed the same founder in 2+ companies: 3 founders

Investments · 28 tracked

founders shown can be your intro path

By year:2026 · 22025 · 22024 · 22021 · 12019 · 22018 · 110 dated

Longevitylongevity.foundationin𝕏✓ verified

The Longevity Science Foundation funds scientific research to address the biological drivers of women's health disparities, particularly ovarian aging and menopause.

BiotechHealthtechImpact & Social GoodLongevityZug, CH

Joshua C. Herring(President & CEO)in

Co-investorsFounders FundKhosla VenturesLilly VenturesThrive Capital

PreCombprecomb.comin✓ verified

PreComb is a Swiss biotech company developing its proprietary 3DTwin technology, which combines automated drug testing on patient-derived tumor twins with AI-guided data analysis and response prediction.

AI & Machine LearningBiotechHealthtechMedical Devices

Co-investorsKinled Holding

Aniani.ai

ANI.AI is a San Francisco research lab building a computational platform for longevity medicine that integrates deep multiomics, longitudinal digital phenotyping, and physician-supervised intervention into a unified model of an individual's biological state.

AI & Machine LearningBiotechLongevitySan Francisco, US

Bruno Balen(Co-Founder, Co-CEO)inNika Pintar(Co-Founder, Co-CEO)in

Co-investorsUntapped Ventures

AOA Dxaoadx.comin𝕏

AOA Dx develops a blood-based liquid biopsy platform using mass spectrometry and machine learning to detect ovarian cancer at early stages through tumor-associated biomarkers in serum.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesDenver, US

Oriana Papin-Zoghbi(Founder)inAlex Fisher(Founder/COO)inAnna Jeter(Founder)inOriana Zoghbi-Harb(Executive Officer, Director)Abigail Mcelhinny(Executive Officer)in

BoardSurbhi Sarna(Director)in

Co-investorsAlleyCorpGood Growth CapitalJoyance PartnersY CombinatorAstiaAurum Venture Partners+36 more

Basepawsbasepaws.cominSeed · Mar 2018

Basepaws offers a DNA testing service for cats that analyzes genetic breed similarity and provides breed breakdown reports for mixed-breed and domestic cats.

BiotechConsumerDirect to ConsumerHealthtechWellness & Fitness

Co-investorsBand of AngelsChloe CapitalIrishAngelsMetropolis VCPasadena AngelsGingerbread Capital+1 more

Catena Biosciencescatenabio.cominMay 2024 · $2.4M

CatenaBio develops precision conjugation technology using native amino acids to enable biotherapeutic fusions of small molecules, nucleic acids, enzymes, and cells.

BiotechDeep TechHealthtechMedical DevicesBerkeley, US

Marco Lobba(Founder)inMatthew Francis(Founder)in

Co-investorsCALIFORNIA INNOVATIONCivilization Ventures Management, LlcCreative Destruction Lab (CDL)FREEFLOWIaso VenturesJude Gomila+14 more

Constructive Bioconstructive.bioin𝕏

Constructive Bio is a biotechnology company that rewrites the genetic code to give cells access to non-canonical amino acid building blocks, expanding the range of proteins that can be designed, engineered, and manufactured.

BiotechDeep TechNew Materials

Jason Chin(Professor)

Co-investors+ND CapitalAmadeus Capital PartnersFine Structures VenturesGENERAL INCEPTIONOMX VenturesPaladin Capital Group+2 more

Deep Longevitydeeplongevity.comin𝕏May 2026

Deep Longevity develops AI-powered aging clocks and health analytics tools that estimate biological age and predict long-term health risks using multi-omics data.

AI & Machine LearningBiotechHealthtechLongevitySaaS

Alex Zhavoronkov(Chief Longevity Advisor)inJamie Alexander Gibson(Executive Director and Chief Executive Officer)Deepankar Nayak(CEO)in

Co-investorsBold Capital PartnersKickstart Innovation

First Longevityfirstlongevity.com𝕏

First Longevity operates a longevity-focused platform, including a daily newsletter covering longevity science, investment, and innovation, and DLT, a data system that tracks longevity companies, signals, and trends.

Data & InfrastructureLongevityMedia & Entertainment

philip newman

Co-investors500 Global

Freedom Biosciencesfreedombio.coin𝕏

Freedom Biosciences develops neuropsychiatric therapeutics, focusing on novel treatments for conditions including depression, PTSD, and alcoholism.

BiotechDigital HealthMental Health

Dr. John Krystal(Co-founder & CEO)inDina Burkitbayeva(Co-founder)in

Co-investorsBeni Venture CapitalEvolution VC PartnersIter InvestmentsManta Ray VenturesPsyMed VenturesUnruly Capital+2 more

Glyphic Biotechnologiesglyphic.bioin𝕏Feb 2024

Glyphic Biotechnologies develops ProSE™, a high-throughput de novo protein sequencing technology for analyzing proteomes with single-molecule sensitivity.

BiotechDeep TechBerkeley, US

Daniel Estandian(Founder)inEd Boyden(Founder)Josh Yang(Founder)in

BoardCraig Asher(Director)inJimmy Yun(Director)in

Co-investorsArtis VenturesBlack FlagCivilization Ventures Management, LlcFoundersX VenturesHarpoon VenturesModi Ventures+7 more

Haut AIhaut.aiin𝕏

Haut.AI analyzes skin condition from selfies using proprietary algorithms and recommends personalized skincare products and routines.

AI & Machine LearningConsumerDigital HealthDirect to ConsumerHealthtechWellness & Fitness

Co-investorsPHD Ventures

Helix Nanotechnologieshelixnano.comin𝕏

Helix Nanotechnologies develops mRNA-based therapeutics for disease treatment and environmental applications, currently advancing a COVID-19 vaccine candidate for immunocompromised patients and testing interventions targeting climate challenges.

AI & Machine LearningBiotechHealthtechBoston, US

Nikolai Eroshenko(Founder/CSO)inHannu Rajaniemi(Founder)in

Co-investorsAlumni VenturesBascom VenturesBeast VenturesChampion Hill VenturesDCVC (Data Collective)Fifty Years+14 more

Insilico Medicineinsilico.comin𝕏Sep 2019

Insilico Medicine uses artificial intelligence to discover and develop new drugs, operating an AI-driven platform for pharmaceutical research and development.

AI & Machine LearningBiotechDigital HealthHealthtechHong Kong, US

Aleksandrs Zavoronkovs(Executive Officer, Director)Alex Zavoronkov(Director)Alex Zhavoronkov(Founder & CEO)inAlex Aliper(President)inFeng Ren(Chief Scientific Officer, Executive Director & Co-CEO)in

BoardNisa Leung(Director)in

Co-investorsLilly Asia VenturesOrbiMedQiming Venture PartnersWarburg PincusBaidu VenturesEight Roads Ventures+13 more

Longenesislongenesis.cominSeed · Jul 2021 · $1.2M

Longenesis operates a platform for health and biomedical data management used to run research studies, including managing study participants across the Baltics and Mediterranean regions.

BiotechCrypto & Web3Digital HealthHealthtech

Co-investorsBitfury

Longevitybiotechlongevitybiotech.org𝕏

The Longevity Biotechnology Association is a global non-profit organization that convenes longevity biotech companies, pharmaceuticals, researchers, and investors to establish industry standards and advance the translation of geroscience into therapeutic interventions that prevent age-related diseases and extend health span.

BiotechHealthtechLongevity

Meliomelio.tech

Melio develops a rapid bloodborne pathogen testing platform that identifies common pathogens from blood samples within hours, replacing traditional multi-day culture-based diagnostics.

AI & Machine LearningBiotechDeep TechHealthtechMedical Devices

Mridu Sinha, PhD(Co-Founder and CEO)Stephanie Fraley, PhD(Co-Founder)

Co-investorsAccelCove FundGeneral CatalystLexi VenturesBessemer Venture PartnersCapital One Ventures+5 more

ProtonIntelprotonintelligence.comin

Proton Intelligence develops CKM™, a continuous monitoring medical device drawing on biosensing and minimally invasive microdevice technology for clinical use.

Deep TechDigital HealthHealthtechMedical Devices

Co-investors15th RockAIN VenturesTenmile

Red Queen Bioredqueen.bioin

Red Queen Bio builds an AI-powered biodefense system that rapidly designs and manufactures countermeasures against emerging biological threats, enabling faster defensive responses to evolving pathogenic risks.

AI & Machine LearningBiotechDefense Tech

Hannu Rajaniemi(Executive Director)inNikolai Eroshenko(CEO)in

Co-investorsCompoundThe Venture CollectiveCerberus VenturesFifty YearsHalcyon Futures InvestmentsOpenAI Startup Fund

Rubedo Life Sciencesrubedolife.comin

Rubedo Life Sciences develops therapeutics targeting aging by eliminating senescent cells to extend human healthspan.

AI & Machine LearningBiotechLongevityMedical Devices

Co-investorsAlumni VenturesBeiersdorf Innovation FundCDP Venture CapitalEvolution VenturesIKJ CapitalKhosla Ventures+4 more

SiPhox Healthsiphoxhealth.comin𝕏

Siphox Health develops early diagnostic testing technology to detect and manage chronic diseases at home, delivered as a painless 5-minute test that enables frequent monitoring.

Digital HealthHealthtechLongevityMedical DevicesWellness & FitnessBoston, US

Michael Dubrovsky(Co-Founder)inDiedrik Vermeulen(Founder)in

Co-investorsDuke Capital PartnersIntel CapitalKoru CapitalNeer Venture PartnersOverlap HoldingsY Combinator+15 more

Trogenixtrogenixbio.cominOct 2025

Trogenix develops precision gene therapies for cancer using its Odysseus platform and Synthetic Super-Enhancer (SSE) technology, engineered DNA elements activated only in diseased cell states to selectively target and kill tumour cells while activating the immune system.

AI & Machine LearningBiotechDeep TechHealthtechMedical Devices

Co-investorsACADEMY INVESTORAIN VenturesCalculus Capital Ltd.IQ CapitalOld College Capital4BIO Capital

Unnatural Productsunnaturalproducts.comin𝕏Sep 2019

Unnatural Products is a drug discovery platform company that develops synthetic macrocycles to target previously undruggable disease targets.

AI & Machine LearningBiotechDeep TechMedical DevicesSanta Cruz, US

Cameron Pye(Co-Founder & CEO)inJoshua Schwochert(Co-Founder & CSO)in

BoardVasudev Bailey(Director)in

Co-investorsAbstract VenturesArtis VenturesAsset Management CompanyBetter Ventures Central LlcBlue Bear VenturesColorcon Ventures+8 more

Valink Therapeuticsvalinktx.cominOct 2025

Valink Therapeutics develops bispecific antibody-drug conjugates (ADCs) for therapeutic applications, combining high-throughput discovery, antibody engineering, and medicinal chemistry capabilities.

AI & Machine LearningBiotechHealthtechMedical DevicesBoston, US

Arne Scheu(Co-Founder & CEO)inIrsyad Khairil(Co-Founder & CTO)in

Co-investorsHoxton VenturesMetaplanetOxonian VenturesP53 InvestRV Invest GmbHSynBioVen+9 more

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Medici TherapeuticsPickMyBrainThe Longevity Biotech AssociationThe Longevity Science Foundation

Portfolio news

latest coverage across their companies

Frequently asked questions

How many investments has LongeVC made?
LongeVC has 28 tracked investments, including 4 dated in the last 24 months.
What stage does LongeVC invest at?
LongeVC invests at the Pre-Seed, Seed, Series A stages.
What sectors does LongeVC focus on?
LongeVC focuses on AI & Machine Learning, Biotech, Digital Health, FemTech, Healthtech, Longevity, Medical Devices, Mental Health, Wellness & Fitness.
Where is LongeVC located?
LongeVC is headquartered in Washington D.C., US.
Who does LongeVC co-invest with?
LongeVC most often shares deals with Y Combinator, The Venture Collective, Artis Ventures, among 128 tracked co-investors.

Media · Podcasts & interviews

featuring the team

🚀 Investing in the Future of Health: Insights from Sergey Jakimov & LongeVC 🔬

Peggy Van de Plassche · Sergey Jakimov

E09: Revolutionizing Biotech Investment | Exclusive Interview with LongeVC's Sergey Jakimov 🌟

HasanTarek POD · Sergey Jakimov

Investing in the Age of Longevity 2022 – Sergey Jakimov – LongeVC

Master Investor · Sergey Jakimov

595th 1Mby1M Roundtable with Sergey Jakimov, LongeVC

1Mby1M Roundtables · Sergey Jakimov

Images

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