FREEFLOW
Venture capitalActively deployingBerkeley · Pre-Seed–Series B · 10 people tracked
Also known as FREEFLOW ENTOS · FREEFLOW IAMBIC · FREEFLOW MANGO · FREEFLOW ONE · FREEFLOW SWITCH · FREEFLOW THREE · FREEFLOW TWO
Investment thesis
Freeflow invests at the earliest stages in science-driven companies leveraging deep tech, proprietary IP, AI and machine learning to advance human and planetary health. The firm sources deal flow from high-quality scientific communities underserved by venture capital, often serving as the first venture investor. It focuses on category-creating companies that use advanced computing to move innovation more efficiently from lab to market. Beyond capital, Freeflow provides non-science value-add support including fundraising, marketing, hiring and strategy, helping portfolio companies attract customers, partners and co-investors as they scale.
Source: firm website, verified Aug 3, 2026.
Team · 10 people
from the firm's website & public directories
What they invest in
from 21 of 34 portfolio companiesBiotech ×11Deep Tech ×7Healthtech ×7AI & Machine Learning ×6Cleantech ×5Medical Devices ×5Climate Tech ×4Hardware ×3
HQs:United States×14
Investments · 34 tracked
founders shown can be your intro pathBy year:2026 · 12024 · 12022 · 13 dated
Pasadena, US
Andrew Singletary(Cofounder)Aaron Ames(Director)Thomas Gurriet(Executive Officer, Director)
Biomarq Health develops a wearable, injectable multi-analyte biosensor platform that continuously monitors biochemical markers such as glucose, lactate, ketones, cortisol, and kidney-related analytes from a single sensor.
Digital HealthHardwareMedical Devices
Katharina(CEO/Co-Founder)Matthew(CTO/Co-Founder)Gunter(CPO)
Miist develops inhaled microparticle therapeutics that deliver medicine to the bloodstream in 30 seconds, targeting conditions like migraine, pain, and anxiety where rapid onset is critical.
BiotechHealthtechMedical DevicesAlameda, US
Eric Ezerins(Cofounder, Head of Technology)inDalton Signor(Cofounder, CEO)inRandy Krebs(Executive Officer)Evan Alfano(Director)Jeffrey Schuster(Chief Technology Officer)
Captura develops electrodialysis technology for direct ocean capture of carbon dioxide from seawater, removing CO₂ while enhancing the ocean's natural carbon removal cycle.
CleantechClimate TechDeep TechPasadena, US
Stephen James Oldham(President and Chief Executive Officer)Chengxiang Xiang(Chief Technology Officer)Michael Wheeler(Director)inBernard David(Chairman of the Board of Directors)Johan Fredrik Pfeiffer(Director)Christene Banda(Secretary)
Erg Bio operates a biomanufacturing platform that converts agricultural and forestry residues into fuels and essential chemicals, aimed at diversifying energy and chemical supply chains.
BiotechCleantechEnergy
Develops geothermal energy solutions.
EnergyPasadena, US
Simon Christopher Jones(Executive Officer, Director, Promoter)
Hydrosat converts satellite and ground data into actionable information for sustainable agriculture and water management.
AgTechClimate TechData & InfrastructureSpace TechWashington, US
Pieter Fossel(CEO)Scott Alan Soenen(Executive Officer)Alan Royce Dalby(Executive Officer, Director)Andrew Robert Dearing(Director)Lori Garver(Director)Adam Niewinski(Director)
Membrion develops electrochemical disinfection (ECD) solutions for wastewater treatment in critical industries, enabling water reuse and mineral recovery.
CleantechSeattle, US
Nic Pannekeet(Director)Bob Warshawer(Director)Thomas Mitchell(Executive Officer)Greg Newbloom(Executive Officer, Director)Wayne Byrne(Executive Officer, Director)John Plaza(Executive Officer, Director)
Mitico provides services across the carbon capture value chain to mitigate carbon emissions and combat climate change.
CleantechClimate TechPasadena, US
Alan Yalun Gu(Director)Edward Rubin(Director)Vincent Brillault(Director)Clement Cid(Executive Officer, Director)
Molecular Instruments develops HCR-based in situ hybridization and immunofluorescence products for detecting and quantifying RNA and protein targets in biological samples.
BiotechHardwareMedical Devices
Nuanced Health operates a preclinical drug discovery and development platform that humanizes the mouse microbiome to recreate the biological heterogeneity of human populations.
AI & Machine LearningBiotechDeep Tech
Deep-tech company Freeflow backed through Seed and Seed+ rounds.
Berkeley, US
Brandon Simmons(Director)Raymond Weitekamp(Executive Officer, Director)Rakesh Jain(Director)
Sift Biosciences develops T-cell immunotherapies for cancer and autoimmune diseases, using an AI-driven discovery platform combined with metagenomics and high-throughput cellular screening to identify microbially derived molecules that activate memory T cells.
AI & Machine LearningBiotechHealthtech
Yue Clare Lou(Co-Founder & CEO)
Transforms stroke diagnosis with non-invasive, non-radiating portable imaging technology.
Switch Therapeutics develops RNA interference (RNAi) therapeutic applications targeting central nervous system diseases, leveraging research from Caltech, Harvard Medical School, and City of Hope.
AI & Machine LearningBiotechDeep TechMedical DevicesSouth San Francisco, US
Kevin Zhang(Director)Alicia Irurzun-Lafitte(Director)Dylan Morris(Director)Si-Ping Han(Secretary)Deepshikha Datta(Chief Executive Officer and President)
Tierra Biosciences develops high-performance protein design technology, serving biotechnology and pharmaceutical industries.
Biotech
TippingPoint Biosciences is a therapeutics company developing a drug discovery platform that targets unstructured regions in chromatin proteins to treat diseases caused by dysfunctional genome chromatin packaging, with a focus on cancer.
BiotechDeep TechHealthtechSan Francisco, US
Laura Hsieh(Founder & CEO)
Vogent is a platform for building AI voice agents that can handle phone calls, powered by custom conversational models and text-to-speech technology.
AI & Machine LearningEnterprise SoftwareSaaSSan Francisco, US
Jagath Vytheeswaran(Founder)inVignesh Varadarajan(Founder)in
ZeoDAC develops direct air capture (DAC) technology using zeolite-based materials to remove carbon dioxide from the atmosphere for climate mitigation and carbon management applications.
CleantechClimate TechDeep TechAtlanta, US
Mark E. Davis(Co-Founder and Executive Strategic Advisor)Christopher W. Jones(Co-Founder and Executive Strategic Advisor)in
Portfolio news
latest coverage across their companiesCaptura · intelligence360.news · Jul 16, 2026
Hydrosat · finance.yahoo.com · Jul 15, 2026
Iambic · geekwire.com · Jul 13, 2026
Vogent · ycombinator.com · Nov 12, 2025
Frequently asked questions
- What stage does FREEFLOW invest at?
- FREEFLOW invests at the Pre-Seed, Seed, Series A, Series B stages.
- What sectors does FREEFLOW focus on?
- FREEFLOW focuses on AI & Machine Learning, Biotech, Cleantech, Climate Tech, Deep Tech, Energy, Hardware, Healthtech, Medical Devices, New Materials, Robotics.
- Where is FREEFLOW located?
- FREEFLOW is headquartered in Berkeley, US.
- Does FREEFLOW lead rounds?
- FREEFLOW typically participates in rounds rather than leading them.
Media · Podcasts & interviews
featuring the teamSolutions to Human & Planetary Challenges with Freeflow - David Fleck
Billy Keels · David Fleck
David Fleck - FreeFlow
LA Venture · David Fleck
Miist: A 30-Second Migraine Therapy
Freeflow Ventures
Mango: Reinventing Microbial QC for the Next Generation of Biomanufacturing
Freeflow Ventures
Iambic Therapeutics: Inside the Company Advancing and Accelerating AI in Drug Development
Freeflow Ventures
From Science to Startup – Freeflow Scientific Advisory Board Insights from Caltech & Berkeley
Freeflow Ventures
Images
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