FREEFLOW
Venture capitalActively deployingBerkeley · Pre-Seed–Series B · 10 people tracked
Also known as FREEFLOW ENTOS · FREEFLOW IAMBIC · FREEFLOW MANGO · FREEFLOW ONE · FREEFLOW SWITCH · FREEFLOW THREE · FREEFLOW TWO
Find your way into FREEFLOW
327 people in our graph share verified history with the FREEFLOW team — schools, employers, funds. One of them is your warm intro.
Investment thesis
Freeflow invests at the earliest stages in science-driven companies leveraging deep tech, proprietary IP, AI and machine learning to advance human and planetary health. The firm sources deal flow from high-quality scientific communities underserved by venture capital, often serving as the first venture investor. It focuses on category-creating companies that use advanced computing to move innovation more efficiently from lab to market. Beyond capital, Freeflow provides non-science value-add support including fundraising, marketing, hiring and strategy, helping portfolio companies attract customers, partners and co-investors as they scale.
Source: firm website, verified Aug 3, 2026.
Team · 10 people
from the firm's website & public directories
What they invest in
from 28 of 33 portfolio companiesBiotech ×15Deep Tech ×15Healthtech ×11AI & Machine Learning ×9Cleantech ×7Medical Devices ×6New Materials ×6Climate Tech ×5
HQs:United States×22
Who they back
founder profiles across 23 portfolio companiesFounding team size:solo founder×102 founders×73 founders×44+ founders×2
Where their founders studiedfrom 30 founders with education data
Caltech ×10UCLA ×3University of Washington ×3Keck School of Medicine of the University of Southern California ×2Massachusetts Institute of Technology ×2The Wharton School ×2University of California, Berkeley ×2University of Michigan ×2
What their founders studiedfrom 30 founders with field-of-study data
Life Sciences ×10Engineering ×9Chemistry ×7Physics ×5Medicine ×4Business & Management ×2Computer Science ×2Mathematics & Statistics ×2
Where their founders worked beforefrom 30 founders with career history
Caltech ×8Iambic Therapeutics, Inc. ×2
25 founders hold a PhD · 2 hold an MBA (of 30 with degree data)
Investments · 33 tracked
founders shown can be your intro pathBy year:2026 · 12025 · 22024 · 12022 · 26 dated
Pasadena, US
Andrew Singletary(Cofounder)Aaron Ames(Director)Thomas Gurriet(Executive Officer, Director)in
Co-investorsTenOneTen Ventures
Aralez Bio produces noncanonical amino acids using biocatalysis, including compounds that add rigidity to peptide backbones and increase enzyme resistance.
BiotechCleantechClimate TechDeep TechNew MaterialsBerkeley, US
Tina Boville(Co-founder & CEO)inDavid Romney(Co-founder)inFrances Arnold(Co-founder / Scientific Founder)
Co-investorsAstiaFifty YearsGood Growth CapitalISVJuniperPaladin Capital Group+1 more
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Biomarq Health develops a wearable, injectable multi-analyte biosensor platform that continuously monitors biochemical markers such as glucose, lactate, ketones, cortisol, and kidney-related analytes from a single sensor.
Digital HealthHardwareMedical Devices
Katharina(CEO/Co-Founder)Matthew(CTO/Co-Founder)Gunter(CPO)
Miist develops inhaled microparticle therapeutics that deliver medicine to the bloodstream in 30 seconds, targeting conditions like migraine, pain, and anxiety where rapid onset is critical.
BiotechHealthtechMedical DevicesAlameda, US
Eric Ezerins(Cofounder, Head of Technology)inDalton Signor(Cofounder, CEO)inRandy Krebs(Executive Officer)Jeffrey Schuster(Chief Technology Officer)inEvan Alfano(Director)
Co-investorsThe Innovation Space
Captura develops Direct Ocean Capture technology using bipolar membrane electrodialysis to remove CO₂ from the upper ocean and atmosphere.
CleantechClimate TechDeep TechPasadena, US
Chengxiang Xiang(Chief Technology Officer)Bernard David(Chairman of the Board of Directors)inHarry Atwater(Chief Science Officer & Co-Founder)inCX Xiang(Chief Technology Officer & Co-Founder)inSteve Oldham(Chief Executive Officer)in
BoardMichael Wheeler(Director)in
Co-investorsEni NextFuture Planet CapitalHitachi VenturesMaersk GrowthMOL SwitchTransLink Capital+3 more
CatenaBio develops precision conjugation technology using native amino acids to enable biotherapeutic fusions of small molecules, nucleic acids, enzymes, and cells.
BiotechDeep TechHealthtechBerkeley, US
Marco Lobba, Ph.D.(Founder)in
Co-investorsLongeVCCaffeinated CapitalCivilization Ventures Management, LlcNYBC Ventures
Erg Bio converts waste biomass into fermentable sugars and intermediates for synthetic aviation fuels and chemicals, using an advanced solvent process and a proprietary yeast that produces enzymes and ferments sugars.
BiotechCleantechEnergyDublin, US
Vineet Rajgarhia(Co-founder & CEO)inBlake Simmons(Co-founder & CTO)inMichael Rabson(Co-founder & Strategic Advisor)in
Co-investorsAzolla VenturesJuniperLichen VenturesChevron Technology Ventures
Esperto Medical is a medical device company developing compact, sensor-based diagnostic and monitoring technology, drawing on expertise in electrical engineering, imaging, and machine learning.
AI & Machine LearningDigital HealthHealthtechMedical DevicesOrange County, US
Alaina Brinley Rajagopal, MD PhD(Founder)inAditya Rajagopal(Co-founder & CEO)inAlaina Brinley Rajagopal(Co-founder & CMO)inYaser Abu-Mostafa(Co-founder)Lynne Rollins(Chief Financial Officer)Raymond Jimenez(Chief Technology Officer)in
Co-investorsBold Capital PartnersCatalyst Health VenturesMaverick VenturesWavemaker Three-Sixty Health
California Catalysts (Calicat) develops non-Iridium catalysts and stack components for hydrogen electrolyzers, using an AI model and a high-throughput discovery engine to identify catalyst materials that lower the levelized cost of hydrogen.
AI & Machine LearningCleantechNew MaterialsLos Angeles, US
Co-investorsYes VC
Holoclara develops therapeutics derived from symbiotic intestinal organisms (helminths) that modulate inflammation, metabolism, and tissue regeneration to address chronic disease, immune-related conditions, and aging.
BiotechHealthtechLongevity
Andrea Choe(CEO / Co-Founder)inPaul W. Sternberg(Co-Founder)inFrank C. Schroeder(Co-Founder)in
Co-investorsHorizons VenturesBOLD CapitalBold Capital PartnersKairos Venture Investments, LlcEndurance28
Hydrosat converts satellite and ground data into actionable information for sustainable agriculture and water management.
AgTechAI & Machine LearningClimate TechData & InfrastructureSpace TechWashington, US
Pieter Fossel(CEO)inScott Alan Soenen(Executive Officer)Alan Royce Dalby(Executive Officer, Director)Yun Jin Kim(Executive Officer)
BoardAndrew Robert Dearing(Director)inAdam Niewinski(Director)in
Co-investorsBlue Bear Capital PartnersExpon CapitalHemisphere Ventures LLCIndustrious VenturesOTB VenturesTechstars+2 more
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Iambic develops AI technologies for drug discovery, using a high-throughput experimental platform to design small-molecule medicines and advance a pipeline of clinical candidates for cancers such as HER2-driven, breast, and ovarian tumors.
AI & Machine LearningBiotechDeep TechSan Diego, US
Tom Miller(Co-Founder & CEO)inFred Manby(Co-Founder & CTO)inThomas Miller(Founder)inNeil Josephson(Chief Medical Officer)inPete Olson(Chief Scientific Officer)inMichael Secora(Chief Financial Officer and Chief Corporate Development Officer)in
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Co-investorsAbingworthAscenta CapitalCatalio Capital ManagementAlumni VenturesCatalio Capital Management, LPCoatue Management+4 more
ImYoo develops a platform that enables continuous, scalable biological data collection from patients outside traditional clinical settings to support precision medicine research and drug development.
BiotechDigital HealthHealthtech
Tatyana Dobreva(Founder)in
Co-investorsPsyMed Ventures
Izote is a fermentation technology company developing an anaerobic process for industrial biomanufacturing.
BiotechDeep TechNew Materials
Co-investorsBee PartnersFTW VenturesJuniperRedstick VenturesCourtyard VenturesEmbark Ventures+1 more
Mango Micro makes the M6, an automated microbial colony counting system that uses machine learning to deliver CFU counts and digitize quality-control labs.
AI & Machine LearningHardwareHealthtech
Co-investorsRiot VenturesSoundproof VenturesBrick Mortar VenturesFirst Check VenturesGreat North VenturesIncisive Ventures
Membrion develops Electro-Ceramic Desalination (ECD) technology that treats complex industrial wastewater by continuously separating dissolved salts and metals, enabling water recovery and reuse without replacing existing infrastructure.
CleantechDeep TechNew MaterialsSeattle, US
Greg Newbloom(Founder & Chief Executive Officer)inThomas Mitchell(Executive Officer)inWayne Byrne(Executive Officer, Director)inJohn Plaza(Executive Officer, Director)inPhillip Pickett(Executive Officer, Director)
BoardNic Pannekeet(Director)in
Co-investorsLam CapitalPangaea Ventures Us Inc.PureTerra VenturesSafar PartnersSand Hill AngelsSeaChange
Mitico develops a post-combustion carbon capture technology that collects and purifies carbon dioxide from flue gases at the source before it enters the atmosphere.
CleantechClimate TechDeep TechPasadena, US
Clement Cid(Executive Officer, Director)inAlan Yalun Gu(Director)
BoardVincent Brillault(Director)Edward Rubin(Director)
Co-investorsAP VenturesHalliburton LabsSOSV
Molecular Instruments develops HCR (hybridization chain reaction) imaging products for enzyme-free, multiplex, quantitative in situ hybridization and immunofluorescence, enabling detection of RNA and protein targets.
BiotechDeep TechHardwareHealthtechMedical DevicesLos Angeles, US
Dr. Harry M.T. Choi(Founder & CEO)Prof. Niles A. Pierce(Founder & Chair of the Board)
Nuanced Health develops healthcare solutions, though the specific product focus is not detailed on this team page.
AI & Machine LearningBiotechDeep TechHealthtechLos Angeles, US
Sarkis Mazmanian(Co-Founder)inYan Yang(Chief Scientific Officer)in
Co-investorsOpen Field CapitalAxial VC
PINC develops nonlinear photonic circuits and devices based on periodically poled thin-film lithium niobate (NanoPPLN) technology for applications ranging from UV to mid-infrared wavelengths.
Deep TechHardwareNew MaterialsSemiconductors
Co-investorsQuantonationAccel-KKRQubits VenturesSutter Hill Ventures
Berkeley, US
Raymond Weitekamp(Executive Officer, Director)in
BoardBrandon Simmons(Director)Rakesh Jain(Director)
Co-investorsBaruch Future VenturesCongruent VenturesISVPangaea Ventures Us Inc.10x FoundersPrime Movers Lab+1 more
Sift Biosciences develops T-cell immunotherapies for cancer and autoimmune diseases, using an AI-driven discovery platform combined with metagenomics and high-throughput cellular screening to identify microbially derived molecules that activate memory T cells.
AI & Machine LearningBiotechHealthtechSan Carlos, US
Yue Clare Lou(Co-Founder & CEO)in
BoardKevin Barrett(Director)inAltar Munis(Director)
Co-investorsEisai Innovation, Inc.SBI HoldingsFifty Years
NeuraNova (formerly StrokeDx) develops non-invasive neurovascular diagnostic technology aimed at rapid detection for stroke and brain-related conditions.
Deep TechHealthtechMedical DevicesCulver City, US
Alexander Ballatori(Cofounder)Shane Shahrestani(Cofounder)in
Co-investorsDigiTx Partners LLC
Switch Therapeutics develops RNA interference (RNAi) therapeutic applications targeting central nervous system diseases, leveraging research from Caltech, Harvard Medical School, and City of Hope.
AI & Machine LearningBiotechDeep TechMedical DevicesSouth San Francisco, US
Si-Ping Han(Secretary)inDeepshikha Datta(Chief Executive Officer and President)
BoardKevin Zhang(Director)Alicia Irurzun-Lafitte(Director)inDylan Morris(Director)in
Co-investorsBold Capital PartnersCRV (Charles River Ventures)Global BrainOno Venture Investment, Inc.Upfront VenturesDigitalis Ventures+2 more
Tierra Biosciences develops high-performance protein design technology, serving biotechnology and pharmaceutical industries.
Biotech
Co-investorsBeresford VenturesCreative VenturesFifty YearsMaterial ImpactHumboldtKdT Ventures+1 more
TippingPoint Biosciences is a therapeutics company developing a drug discovery platform that targets unstructured regions in chromatin proteins to treat diseases caused by dysfunctional genome chromatin packaging, with a focus on cancer.
BiotechDeep TechHealthtechSan Francisco, US
Laura Hsieh(Founder & CEO)in
Co-investorsBrightEdgeSazzeSOSVStoryHouse
Vogent is a platform for building AI voice agents that can handle phone calls, powered by custom conversational models and text-to-speech technology.
AI & Machine LearningEnterprise SoftwareSaaSSan Francisco, US
Jagath Vytheeswaran(Founder)inVignesh Varadarajan(Founder)in
Co-investorsXG VenturesY Combinator
Wild Microbes uses synthetic biology to engineer microbes sourced from diverse wild biomes into production hosts for biomanufacturing high-performance ingredients.
BiotechDeep TechNew Materials
Timothy Wannier(Founder)in
Co-investorsAgronomicsCoalitionJuniperSiddhi CapitalFall Line Capital
ZeoDAC develops direct air capture (DAC) technology using zeolite-based materials to remove carbon dioxide from the atmosphere for climate mitigation and carbon management applications.
CleantechClimate TechDeep TechAtlanta, US
Mark E. Davis(Co-Founder and Executive Strategic Advisor)Christopher W. Jones(Co-Founder and Executive Strategic Advisor)in
Co-investorsGlobal Brain
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
EquilibrFlion EnergyMiistPINC Technologies
Portfolio news
latest coverage across their companiesMango · beincrypto.com · Sep 3, 2026
Captura · desmoinesregister.com · Aug 18, 2026
Hydrosat · norfolkdailynews.com · Jul 15, 2026
Iambic · geekwire.com · Jul 13, 2026
3Laws Robotics · robotics.press · Apr 27, 2026
TippingPoint Biosciences · icemiller.com · Apr 22, 2026
Izote · beepartners.vc · Apr 20, 2026
Sift Biosciences · finsmes.com · Feb 19, 2026
Frequently asked questions
- How many investments has FREEFLOW made?
- FREEFLOW has 33 tracked investments, 1 of which have exited, including 4 dated in the last 24 months.
- What stage does FREEFLOW invest at?
- FREEFLOW invests at the Pre-Seed, Seed, Series A, Series B stages.
- What sectors does FREEFLOW focus on?
- FREEFLOW focuses on AI & Machine Learning, Biotech, Cleantech, Climate Tech, Deep Tech, Energy, Hardware, Healthtech, Medical Devices, New Materials, Robotics.
- Where is FREEFLOW located?
- FREEFLOW is headquartered in Berkeley, US.
- Does FREEFLOW lead rounds?
- FREEFLOW typically participates in rounds rather than leading them.
- Who does FREEFLOW co-invest with?
- FREEFLOW most often shares deals with Juniper, Bold Capital Partners, Fifty Years, among 63 tracked co-investors.
Media · Podcasts & interviews
featuring the teamSolutions to Human & Planetary Challenges with Freeflow - David Fleck
Billy Keels · David Fleck
David Fleck - FreeFlow
LA Venture · David Fleck
Miist: A 30-Second Migraine Therapy
Freeflow Ventures
Mango: Reinventing Microbial QC for the Next Generation of Biomanufacturing
Freeflow Ventures
Iambic Therapeutics: Inside the Company Advancing and Accelerating AI in Drug Development
Freeflow Ventures
From Science to Startup – Freeflow Scientific Advisory Board Insights from Caltech & Berkeley
Freeflow Ventures
Images
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