FREEFLOW
Venture capitalActively deployingBerkeley · Pre-Seed–Series B · 10 people tracked
Also known as FREEFLOW ENTOS · FREEFLOW IAMBIC · FREEFLOW MANGO · FREEFLOW ONE · FREEFLOW SWITCH · FREEFLOW THREE · FREEFLOW TWO
Investment thesis
Freeflow invests at the earliest stages in science-driven companies leveraging deep tech, proprietary IP, AI and machine learning to advance human and planetary health. The firm sources deal flow from high-quality scientific communities underserved by venture capital, often serving as the first venture investor. It focuses on category-creating companies that use advanced computing to move innovation more efficiently from lab to market. Beyond capital, Freeflow provides non-science value-add support including fundraising, marketing, hiring and strategy, helping portfolio companies attract customers, partners and co-investors as they scale.
Source: firm website, verified Aug 3, 2026.
Team · 10 people
from the firm's website & public directories
What they invest in
from 27 of 33 portfolio companiesBiotech ×15Deep Tech ×12Healthtech ×9AI & Machine Learning ×8Cleantech ×6Medical Devices ×6Climate Tech ×4Hardware ×4
HQs:United States×19
Who they back
founder profiles across 17 portfolio companiesFounding team size:solo founder×62 founders×63 founders×44+ founders×1
Investments · 33 tracked
founders shown can be your intro pathBy year:2026 · 12025 · 12024 · 12022 · 14 dated
Pasadena, US
Andrew Singletary(Cofounder)Aaron Ames(Director)Thomas Gurriet(Executive Officer, Director)
Co-investorsTenOneTen Ventures
Aralez Bio uses an enzyme-based (biocatalysis) platform to produce noncanonical amino acids and protected amino acid building blocks for peptide therapeutic discovery and manufacturing teams.
BiotechCleantechNew MaterialsBerkeley, US
Co-investorsAstiaFifty YearsGood Growth CapitalISVJuniperPaladin Capital Group+1 more
Biomarq Health develops a wearable, injectable multi-analyte biosensor platform that continuously monitors biochemical markers such as glucose, lactate, ketones, cortisol, and kidney-related analytes from a single sensor.
Digital HealthHardwareMedical Devices
Katharina(CEO/Co-Founder)Matthew(CTO/Co-Founder)Gunter(CPO)
Miist develops inhaled microparticle therapeutics that deliver medicine to the bloodstream in 30 seconds, targeting conditions like migraine, pain, and anxiety where rapid onset is critical.
BiotechHealthtechMedical DevicesAlameda, US
Eric Ezerins(Cofounder, Head of Technology)inDalton Signor(Cofounder, CEO)inRandy Krebs(Executive Officer)Jeffrey Schuster(Chief Technology Officer)Evan Alfano(Director)
Co-investorsThe Innovation Space
Captura develops Direct Ocean Capture technology using bipolar membrane electrodialysis to remove CO₂ from the upper ocean and atmosphere.
CleantechClimate TechDeep TechPasadena, US
Chengxiang Xiang(Chief Technology Officer)Bernard David(Chairman of the Board of Directors)Harry Atwater(Executive Officer, Director)inStephen James Oldham(President and Chief Executive Officer)
BoardMichael Wheeler(Director)inEd Phillips(Director)in
Co-investorsEni NextFuture Planet CapitalHitachi VenturesMaersk GrowthMOL SwitchTransLink Capital+3 more
Catena Biosciences develops therapeutics using its CysTyr conjugation platform to create Multi-Payload Conjugates (MPCs), a next-generation form of antibody-drug conjugate that delivers dual payloads.
BiotechHealthtechBerkeley, US
Co-investorsLongeVCNYBC Ventures
Co-investorsThe E14 Fund
Erg Bio converts waste biomass into fermentable sugars and intermediates for synthetic aviation fuels and chemicals, using an advanced solvent process and a proprietary yeast that produces enzymes and ferments sugars.
BiotechCleantechEnergyDublin, US
Vineet Rajgarhia(Co-founder)inBlake Simmons(Co-founder)inMichael Rabson(Co-founder)in
Co-investorsAzolla VenturesJuniperLichen VenturesChevron Technology Ventures
Esperto Medical is a medical device company developing compact, sensor-based diagnostic and monitoring technology, drawing on expertise in electrical engineering, imaging, and machine learning.
AI & Machine LearningDigital HealthHealthtechMedical DevicesOrange County, US
Alaina Brinley Rajagopal, MD PhD(Founder)inAditya Rajagopal(Co-founder & CEO)Alaina Brinley Rajagopal(Co-founder & CMO)Yaser Abu-Mostafa(Co-founder)Lynne Rollins(Chief Financial Officer)Raymond Jimenez(Chief Technology Officer)
Co-investorsBold Capital PartnersCatalyst Health VenturesMaverick VenturesWavemaker Three-Sixty Health
Develops geothermal energy solutions.
EnergyPasadena, US
Simon Christopher Jones(Executive Officer, Director, Promoter)
Co-investorsYes VC
Holoclara develops therapeutics derived from symbiotic intestinal organisms (helminths) that modulate inflammation, metabolism, and tissue regeneration to address chronic disease, immune-related conditions, and aging.
BiotechHealthtechLongevity
Andrea Choe(CEO / Co-Founder)inPaul W. Sternberg(Co-Founder)Frank C. Schroeder(Co-Founder)
Co-investorsHorizons VenturesBOLD CapitalBold Capital PartnersKairos Venture Investments, LlcEndurance28
Hydrosat converts satellite and ground data into actionable information for sustainable agriculture and water management.
AgTechAI & Machine LearningClimate TechData & InfrastructureSpace TechWashington, US
Pieter Fossel(CEO)Scott Alan Soenen(Executive Officer)Alan Royce Dalby(Executive Officer, Director)Yun Jin Kim(Executive Officer)
BoardAndrew Robert Dearing(Director)inAdam Niewinski(Director)in
Co-investorsBlue Bear Capital PartnersExpon CapitalHemisphere Ventures LLCIndustrious VenturesOTB VenturesTechstars+2 more
Iambic develops AI technologies for drug discovery, using a high-throughput experimental platform to design small-molecule medicines and advance a pipeline of clinical candidates for cancers such as HER2-driven, breast, and ovarian tumors.
AI & Machine LearningBiotechDeep TechSan Diego, US
Tom Miller(Co-Founder & CEO)inFred Manby(Co-Founder & CTO)inThomas Miller(Founder)inNeil Josephson(Chief Medical Officer)inPete Olson(Chief Scientific Officer)inMichael Secora(Chief Financial Officer and Chief Corporate Development Officer)in
Co-investorsAbingworthAscenta CapitalCatalio Capital ManagementAlumni VenturesCatalio Capital Management, LPCoatue Management+4 more
ImYoo is a Public Benefit Corporation that provides at-home immune sample collection kits and molecular profiling to map patients' experiences to their underlying biology.
BiotechDigital HealthHealthtech
Co-investorsPsyMed Ventures
Izote is a fermentation technology company developing an anaerobic process for industrial biomanufacturing.
BiotechDeep TechNew Materials
Co-investorsBee PartnersFTW VenturesJuniperRedstick VenturesCourtyard VenturesEmbark Ventures+1 more
Mango Micro makes the M6, an automated microbial colony counting system that uses machine learning to deliver CFU counts and digitize quality-control labs.
AI & Machine LearningHardwareHealthtech
Co-investorsRiot VenturesSoundproof Ventures
Membrion develops Electro-Ceramic Desalination (ECD) technology that treats complex industrial wastewater by continuously separating dissolved salts and metals, enabling water recovery and reuse without replacing existing infrastructure.
CleantechDeep TechNew MaterialsSeattle, US
Greg Newbloom(Executive Officer, Director)Thomas Mitchell(Executive Officer)Wayne Byrne(Executive Officer, Director)John Plaza(Executive Officer, Director)Phillip Pickett(Executive Officer, Director)
BoardNic Pannekeet(Director)in
Co-investorsLam CapitalPangaea Ventures Us Inc.PureTerra VenturesSafar PartnersSeaChangeSand Hill Angels
Mitico develops a post-combustion carbon capture technology that collects and purifies carbon dioxide from flue gases at the source before it enters the atmosphere.
CleantechClimate TechDeep TechPasadena, US
Clement Cid(Executive Officer, Director)Alan Yalun Gu(Director)
BoardVincent Brillault(Director)Edward Rubin(Director)
Co-investorsAP VenturesHalliburton LabsSOSV
Molecular Instruments develops HCR-based in situ hybridization and immunofluorescence products for detecting and quantifying RNA and protein targets in biological samples.
BiotechHardwareMedical Devices
Nuanced Health operates a preclinical drug discovery and development platform that humanizes the mouse microbiome to recreate the biological heterogeneity of human populations.
AI & Machine LearningBiotechDeep Tech
Co-investorsOpen Field CapitalAxial VC
PINC develops the NanoPPLN platform, which integrates nonlinear optical circuits into photonic integrated chips (PICs) to make scalable nonlinear optics fully integrated.
Deep TechHardwareSemiconductors
Co-investorsQuantonationAccel-KKRQubits VenturesSutter Hill Ventures
Deep-tech company Freeflow backed through Seed and Seed+ rounds.
Berkeley, US
Raymond Weitekamp(Executive Officer, Director)
BoardBrandon Simmons(Director)Rakesh Jain(Director)
Co-investorsBaruch Future VenturesCongruent VenturesISVPangaea Ventures Us Inc.10x FoundersPrime Movers Lab+1 more
Sift Biosciences develops T-cell immunotherapies for cancer and autoimmune diseases, using an AI-driven discovery platform combined with metagenomics and high-throughput cellular screening to identify microbially derived molecules that activate memory T cells.
AI & Machine LearningBiotechHealthtechSan Carlos, US
Yue Clare Lou(Co-Founder & CEO)inYue Lou(Executive Officer, Director)
BoardKevin Barrett(Director)Altar Munis(Director)
Co-investorsEisai Innovation, Inc.SBI HoldingsFifty Years
NeuraNova (formerly StrokeDx) develops non-invasive neurovascular diagnostic technology aimed at rapid detection for stroke and brain-related conditions.
Deep TechHealthtechMedical DevicesCulver City, US
Alexander Ballatori(Cofounder)Shane Shahrestani(Cofounder)
Co-investorsDigiTx Partners LLC
Switch Therapeutics develops RNA interference (RNAi) therapeutic applications targeting central nervous system diseases, leveraging research from Caltech, Harvard Medical School, and City of Hope.
AI & Machine LearningBiotechDeep TechMedical DevicesSouth San Francisco, US
Si-Ping Han(Secretary)Deepshikha Datta(Chief Executive Officer and President)
BoardKevin Zhang(Director)Alicia Irurzun-Lafitte(Director)inDylan Morris(Director)
Co-investorsBold Capital PartnersCRV (Charles River Ventures)Global BrainOno Venture Investment, Inc.Upfront VenturesDigitalis Ventures+2 more
Tierra Biosciences develops high-performance protein design technology, serving biotechnology and pharmaceutical industries.
Biotech
Co-investorsBeresford VenturesCreative VenturesFifty YearsMaterial ImpactHumboldtKdT Ventures+1 more
TippingPoint Biosciences is a therapeutics company developing a drug discovery platform that targets unstructured regions in chromatin proteins to treat diseases caused by dysfunctional genome chromatin packaging, with a focus on cancer.
BiotechDeep TechHealthtechSan Francisco, US
Laura Hsieh(Founder & CEO)in
Co-investorsBrightEdge
Vogent is a platform for building AI voice agents that can handle phone calls, powered by custom conversational models and text-to-speech technology.
AI & Machine LearningEnterprise SoftwareSaaSSan Francisco, US
Jagath Vytheeswaran(Founder)inVignesh Varadarajan(Founder)in
Co-investorsXG VenturesY Combinator
Wild Microbes uses synthetic biology to engineer microbes sourced from diverse wild biomes into production hosts for biomanufacturing high-performance ingredients.
BiotechDeep TechNew Materials
Co-investorsAgronomicsCoalitionJuniperSiddhi CapitalFall Line Capital
ZeoDAC develops direct air capture (DAC) technology using zeolite-based materials to remove carbon dioxide from the atmosphere for climate mitigation and carbon management applications.
CleantechClimate TechDeep TechAtlanta, US
Mark E. Davis(Co-Founder and Executive Strategic Advisor)Christopher W. Jones(Co-Founder and Executive Strategic Advisor)in
Co-investorsGlobal Brain
Portfolio news
latest coverage across their companies
Captura · desmoinesregister.com · Aug 18, 2026
Hydrosat · norfolkdailynews.com · Jul 15, 2026
Iambic · geekwire.com · Jul 13, 2026
Izote · beepartners.vc · Apr 20, 2026
PINC · agfundernews.com · Dec 9, 2025
Vogent · ycombinator.com · Nov 12, 2025
Membrion · finsmes.com · Oct 8, 2025
Frequently asked questions
- How many investments has FREEFLOW made?
- FREEFLOW has 31 tracked investments, 1 of which have exited via acquisition or IPO, including 3 dated in the last 24 months.
- What stage does FREEFLOW invest at?
- FREEFLOW invests at the Pre-Seed, Seed, Series A, Series B stages.
- What sectors does FREEFLOW focus on?
- FREEFLOW focuses on AI & Machine Learning, Biotech, Cleantech, Climate Tech, Deep Tech, Energy, Hardware, Healthtech, Medical Devices, New Materials, Robotics.
- Where is FREEFLOW located?
- FREEFLOW is headquartered in Berkeley, US.
- Does FREEFLOW lead rounds?
- FREEFLOW typically participates in rounds rather than leading them.
- Who does FREEFLOW co-invest with?
- FREEFLOW most often shares deals with Juniper, Bold Capital Partners, Fifty Years, among 61 tracked co-investors.
Media · Podcasts & interviews
featuring the teamSolutions to Human & Planetary Challenges with Freeflow - David Fleck
Billy Keels · David Fleck
David Fleck - FreeFlow
LA Venture · David Fleck
Miist: A 30-Second Migraine Therapy
Freeflow Ventures
Mango: Reinventing Microbial QC for the Next Generation of Biomanufacturing
Freeflow Ventures
Iambic Therapeutics: Inside the Company Advancing and Accelerating AI in Drug Development
Freeflow Ventures
From Science to Startup – Freeflow Scientific Advisory Board Insights from Caltech & Berkeley
Freeflow Ventures
Images
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