Fundraising Fox
FREEFLOW
Venture capitalActively deployingBerkeley · Pre-Seed–Series A · 9 people tracked
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Investment thesis
Freeflow backs early-stage, science-driven deep tech founders, with a particular focus on the research communities of Caltech and Berkeley. It invests across human health (therapeutics, diagnostics, medical devices, drug discovery platforms, consumer health, biomanufacturing) and planetary health (robotics, carbon capture, energy, water, geospatial data, advanced manufacturing, advanced electronics), favoring companies leveraging computer science, AI and machine learning with billion-dollar market potential. The firm makes disciplined, high-conviction bets and provides hands-on support beyond capital in fundraising, marketing, recruiting and strategy, spending months or years with founders before investing.
Source: firm website, verified Sep 27, 2026.
Team · 9 people
from the firm's website & public directories
What they invest in
from 28 of 35 portfolio companiesBiotech ×15Deep Tech ×15Healthtech ×11AI & Machine Learning ×9Cleantech ×7Medical Devices ×7New Materials ×6Climate Tech ×5
HQs:United States×23
Who they back
founder profiles across 24 portfolio companiesFounding team size:solo founder×102 founders×83 founders×54+ founders×1
Where their founders studiedfrom 28 founders with education data
Caltech ×8University of Washington ×3Massachusetts Institute of Technology ×2The Wharton School ×2UCLA ×2University of Michigan ×2
What their founders studiedfrom 30 founders with field-of-study data
Life Sciences ×10Engineering ×9Chemistry ×7Physics ×5Medicine ×4Business & Management ×2Computer Science ×2Mathematics & Statistics ×2
Where their founders worked beforefrom 28 founders with career history
Caltech ×9UC Berkeley ×2
Accelerator rootsportfolio companies that came through a program
25 founders hold a PhD · 2 hold an MBA (of 30 with degree data)
Investments · 35 tracked
founders shown can be your intro pathBy year:2026 · 12025 · 22024 · 12022 · 26 dated
Pasadena, US
Andrew Singletary(Cofounder)Aaron Ames(Director)Thomas Gurriet(Executive Officer, Director)in
Co-investorsEmbark VenturesTenOneTen Ventures
Aralez Bio produces noncanonical amino acids using biocatalysis, including compounds that add rigidity to peptide backbones and increase enzyme resistance.
BiotechCleantechClimate TechDeep TechNew MaterialsBerkeley, US
Tina Boville(Co-founder & CEO)inDavid Romney(Co-founder)inFrances Arnold(Co-founder / Scientific Founder)
Co-investorsAstiaFifty YearsGood Growth CapitalISVJuniperPaladin Capital Group+2 more
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Biomarq Health develops a wearable, injectable multi-analyte biosensor platform that continuously monitors biochemical markers such as glucose, lactate, ketones, cortisol, and kidney-related analytes from a single sensor.
Digital HealthHardwareMedical Devices
Katharina(CEO/Co-Founder)Matthew(CTO/Co-Founder)Gunter(CPO)
Miist develops inhaled microparticle therapeutics that deliver medicine to the bloodstream in 30 seconds, targeting conditions like migraine, pain, and anxiety where rapid onset is critical.
BiotechDigital HealthHealthtechMedical DevicesAlameda, US
Eric Ezerins(Cofounder, Head of Technology)inDalton Signor(Cofounder, CEO)inRandy Krebs(Executive Officer)Jeffrey Schuster(Chief Technology Officer)inEvan Alfano(Director)
Co-investorsCAL InnovationCalifornia Innovation FundEntrepreneur FirstThe Innovation SpaceRefactor Capital
Captura develops Direct Ocean Capture technology using bipolar membrane electrodialysis to remove CO₂ from the upper ocean and atmosphere.
CleantechClimate TechDeep TechPasadena, US
Chengxiang Xiang(Founder)Bernard David(Chairman of the Board of Directors)inHarry Atwater(Founder)inCX Xiang(Chief Technology Officer & Co-Founder)inSteve Oldham(Chief Executive Officer)in
BoardMichael Wheeler(Director)in
Co-investorsEni NextFuture Planet CapitalHitachi VenturesMaersk GrowthMOL SwitchTransLink Capital+3 more
CatenaBio develops precision conjugation technology using native amino acids to enable biotherapeutic fusions of small molecules, nucleic acids, enzymes, and cells.
BiotechDeep TechHealthtechMedical DevicesBerkeley, US
Marco Lobba(Founder)inMatthew Francis(Founder)inGeo Guillen
Co-investorsCalifornia Innovation FundCivilization Ventures Management, LlcCreative Destruction Lab (CDL)Iaso VenturesJude GomilaLongeVC+14 more
Erg Bio converts waste biomass into fermentable sugars and intermediates for synthetic aviation fuels and chemicals, using an advanced solvent process and a proprietary yeast that produces enzymes and ferments sugars.
BiotechCleantechEnergyDublin, US
Vineet Rajgarhia(Co-founder & CEO)inBlake Simmons(Co-founder & CTO)inMichael Rabson(Co-founder & Strategic Advisor)in
Co-investorsAzolla VenturesJuniperLichen VenturesChevron Technology Ventures
Esperto Medical is a medical device company developing compact, sensor-based diagnostic and monitoring technology, drawing on expertise in electrical engineering, imaging, and machine learning.
AI & Machine LearningDigital HealthHealthtechMedical DevicesOrange County, US
Alaina Brinley Rajagopal(Founder)inAditya Rajagopal(Co-founder & CEO)inYaser Abu-Mostafa(Co-founder)Lynne Rollins(Chief Financial Officer)Raymond Jimenez(Chief Technology Officer)inJeff Stoll(Chief Product Officer)in
Co-investorsBold Capital PartnersCatalyst Health VenturesMaverick VenturesWavemaker Three-Sixty Health
California Catalysts (Calicat) develops non-Iridium catalysts and stack components for hydrogen electrolyzers, using an AI model and a high-throughput discovery engine to identify catalyst materials that lower the levelized cost of hydrogen.
AI & Machine LearningCleantechNew MaterialsLos Angeles, US
Co-investorsYes VC
Holoclara develops therapeutics derived from symbiotic intestinal organisms (helminths) that modulate inflammation, metabolism, and tissue regeneration to address chronic disease, immune-related conditions, and aging.
BiotechHealthtechLongevity
Andrea Choe(CEO / Co-Founder)inPaul W. Sternberg(Co-Founder)inFrank C. Schroeder(Co-Founder)in
Co-investorsHorizons VenturesBold Capital PartnersEndurance28Kairos Venture Investments, LlcSV Latam Capital
Hydrosat converts satellite and ground data into actionable information for sustainable agriculture and water management.
AgTechAI & Machine LearningClimate TechData & InfrastructureSpace TechWashington, US
Pieter Fossel(CEO)inScott Alan Soenen(Executive Officer)Alan Royce Dalby(Executive Officer, Director)Yun Jin Kim(Executive Officer)
BoardAndrew Robert Dearing(Director)inAdam Niewinski(Director)in
Co-investorsBlue Bear Capital PartnersExpon CapitalHemisphere Ventures LLCIndustrious VenturesNextwave [X] PartnersOTB Ventures+7 more
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Iambic develops AI technologies for drug discovery, using a high-throughput experimental platform to design small-molecule medicines and advance a pipeline of clinical candidates for cancers such as HER2-driven, breast, and ovarian tumors.
AI & Machine LearningBiotechDeep TechSan Diego, US
Tom Miller(Founder)inFred Manby(Founder)inChao Zhang(Executive Officer)inTabbert Teng(Executive Officer)Neil Josephson(Chief Medical Officer)inPete Olson(Chief Scientific Officer)in
Co-investorsAscenta CapitalAbingworthCatalio Capital ManagementAlumni VenturesCatalio Capital Management, LPCoatue Management+7 more
ImYoo develops a platform that enables continuous, scalable biological data collection from patients outside traditional clinical settings to support precision medicine research and drug development.
BiotechDigital HealthHealthtech
Tatyana Dobreva(Founder)in
Co-investorsPsyMed Ventures
Izote is a fermentation technology company developing an anaerobic process for industrial biomanufacturing.
BiotechDeep TechNew MaterialsBerkeley, US
Victor Reyes-Umaña, PhD(Founder & CEO)
Co-investorsBee PartnersEmbark VenturesFTW VenturesJuniperRedstick VenturesCourtyard Ventures+1 more
Mango Micro makes the M6, an automated microbial colony counting system that uses machine learning to deliver CFU counts and digitize quality-control labs.
AI & Machine LearningHardwareHealthtech
Co-investorsRiot VenturesSoundproof VenturesBrick Mortar VenturesFirst Check VenturesGreat North VenturesIncisive Ventures
Membrion develops Electro-Ceramic Desalination (ECD) technology that treats complex industrial wastewater by continuously separating dissolved salts and metals, enabling water recovery and reuse without replacing existing infrastructure.
CleantechDeep TechNew MaterialsSeattle, US
Greg Newbloom(Founder & Chief Executive Officer)inThomas Mitchell(Executive Officer)inWayne Byrne(Executive Officer, Director)inJohn Plaza(Executive Officer, Director)inPhillip Pickett(Executive Officer, Director)
BoardNic Pannekeet(Director)in
Co-investorsE8 AngelsLam CapitalPangaea Ventures Us Inc.PureTerra VenturesSafar PartnersSand Hill Angels+2 more
Mitico develops a post-combustion carbon capture technology that collects and purifies carbon dioxide from flue gases at the source before it enters the atmosphere.
CleantechClimate TechDeep TechPasadena, US
Clement Cid(Executive Officer, Director)inAlan Yalun Gu(Director)
BoardVincent Brillault(Director)Edward Rubin(Director)
Co-investorsAP VenturesHalliburton LabsSOSV
Molecular Instruments develops HCR (hybridization chain reaction) imaging products for enzyme-free, multiplex, quantitative in situ hybridization and immunofluorescence, enabling detection of RNA and protein targets.
BiotechDeep TechHardwareHealthtechMedical DevicesLos Angeles, US
Dr. Harry M.T. Choi(Founder & CEO)Prof. Niles A. Pierce(Founder & Chair of the Board)
Nuanced Health develops healthcare solutions, though the specific product focus is not detailed on this team page.
AI & Machine LearningBiotechDeep TechHealthtechLos Angeles, US
Sarkis Mazmanian(Co-Founder)inYan Yang(Chief Scientific Officer)in
Co-investorsOpen Field CapitalAxial VC
PINC develops nonlinear photonic circuits and devices based on periodically poled thin-film lithium niobate (NanoPPLN) technology for applications ranging from UV to mid-infrared wavelengths.
Deep TechHardwareNew MaterialsSemiconductors
Co-investorsQuantonationAccel-KKRQubits VenturesSutter Hill Ventures
Berkeley, US
Raymond Weitekamp(Executive Officer, Director)in
BoardBrandon Simmons(Director)Rakesh Jain(Director)
Co-investorsBaruch Future VenturesCongruent VenturesHarmonix FundISVPangaea Ventures Us Inc.10x Founders+3 more
Sift Biosciences develops T-cell immunotherapies for cancer and autoimmune diseases, using an AI-driven discovery platform combined with metagenomics and high-throughput cellular screening to identify microbially derived molecules that activate memory T cells.
AI & Machine LearningBiotechHealthtechSan Carlos, US
Yue Clare Lou(Co-Founder & CEO)in
BoardKevin Barrett(Director)inAltar Munis(Director)
Co-investorsEisai Innovation, Inc.SBI HoldingsFifty YearsLifespan Vision Ventures
NeuraNova (formerly StrokeDx) develops non-invasive neurovascular diagnostic technology aimed at rapid detection for stroke and brain-related conditions.
Deep TechHealthtechMedical DevicesCulver City, US
Alexander Ballatori(Cofounder)Shane Shahrestani(Cofounder)in
Co-investorsDigiTx Partners LLC
Switch Therapeutics develops RNA interference (RNAi) therapeutic applications targeting central nervous system diseases, leveraging research from Caltech, Harvard Medical School, and City of Hope.
AI & Machine LearningBiotechDeep TechMedical DevicesSouth San Francisco, US
Si-Ping Han(Secretary)inDeepshikha Datta(Chief Executive Officer and President)
BoardKevin Zhang(Director)Alicia Irurzun-Lafitte(Director)inDylan Morris(Director)in
Co-investorsBold Capital PartnersCRV (Charles River Ventures)Dolby Family VenturesGlobal BrainOno Venture Investment, Inc.Upfront Ventures+3 more
Tierra Biosciences develops high-performance protein design technology, serving biotechnology and pharmaceutical industries.
Biotech
Co-investorsBeresford VenturesCreative VenturesFifty YearsIn-Q-TelMaterial ImpactHumboldt+2 more
TippingPoint Biosciences is a therapeutics company developing a drug discovery platform that targets unstructured regions in chromatin proteins to treat diseases caused by dysfunctional genome chromatin packaging, with a focus on cancer.
BiotechDeep TechHealthtechSan Francisco, US
Laura Hsieh(Founder & CEO)in
Co-investorsBrightEdgeEmpath VenturesSazzeSOSVStoryHouseXEIA Venture Partners
Vogent is a platform for building AI voice agents that can handle phone calls, powered by custom conversational models and text-to-speech technology.
AI & Machine LearningEnterprise SoftwareSaaSSan Francisco, US
Jagath Vytheeswaran(Founder)inVignesh Varadarajan(Founder)inKushal Tirumala
Co-investorsBlackbird VenturesXG VenturesY CombinatorGlobal Founders CapitalHydrocarbon Minerals 4Niche Capital+1 more
Wild Microbes uses synthetic biology to engineer microbes sourced from diverse wild biomes into production hosts for biomanufacturing high-performance ingredients.
BiotechDeep TechNew Materials
Timothy Wannier(Founder)in
Co-investorsAgronomicsCoalitionCollaborative FundJuniperSiddhi CapitalThird Derivative+2 more
ZeoDAC develops direct air capture (DAC) technology using zeolite-based materials to remove carbon dioxide from the atmosphere for climate mitigation and carbon management applications.
CleantechClimate TechDeep TechAtlanta, US
Mark E. Davis(Co-Founder and Executive Strategic Advisor)Christopher W. Jones(Co-Founder and Executive Strategic Advisor)in
Co-investorsAccelr8Global Brain
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
EquilibrFlion EnergyLaguna BioMiistNeuronovaPINC Technologies
Portfolio news
latest coverage across their companies
TippingPoint Biosciences · trysignalbase.com · Apr 2, 2026
Vogent · ycombinator.com · Nov 12, 2025
Membrion · finsmes.com · Oct 8, 2025
Holoclara · holoclara.com · Aug 28, 2025
Frequently asked questions
- How many investments has FREEFLOW made?
- FREEFLOW has 35 tracked investments, 1 of which have exited, including 4 dated in the last 24 months.
- What stage does FREEFLOW invest at?
- FREEFLOW invests at the Pre-Seed, Seed, Series A stages.
- What sectors does FREEFLOW focus on?
- FREEFLOW focuses on Advanced Manufacturing, AI & Machine Learning, Biotech, Cleantech, Climate Tech, Deep Tech, Energy, Hardware, Healthtech, Medical Devices, New Materials, Robotics.
- Where is FREEFLOW located?
- FREEFLOW is headquartered in Berkeley, US.
- Does FREEFLOW lead rounds?
- FREEFLOW typically participates in rounds rather than leading them.
- Who does FREEFLOW co-invest with?
- FREEFLOW most often shares deals with Juniper, Bold Capital Partners, Fifty Years, among 89 tracked co-investors.
Media · Podcasts & interviews
featuring the teamSolutions to Human & Planetary Challenges with Freeflow - David Fleck
Billy Keels · David Fleck
David Fleck - FreeFlow
LA Venture · David Fleck
Miist: A 30-Second Migraine Therapy
Freeflow Ventures
Mango: Reinventing Microbial QC for the Next Generation of Biomanufacturing
Freeflow Ventures
Iambic Therapeutics: Inside the Company Advancing and Accelerating AI in Drug Development
Freeflow Ventures
From Science to Startup – Freeflow Scientific Advisory Board Insights from Caltech & Berkeley
Freeflow Ventures
Images
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