Define Ventures
Venture capitalSan Francisco · Pre-Seed–Series C · 28 people tracked
Also known as DEFINE VENTURES MANAGEMENT, LLC
Investment thesis
Define Ventures invests in early-stage health tech companies, backing entrepreneurs building category-defining businesses at the convergence of technology innovation, evolving consumer preferences, and structural shifts within the healthcare industry. The firm believes these trends will shape the future of healthcare for generations. It combines a curated team of founders, investors, and operators drawn from both Silicon Valley and healthcare, along with a deep advisor bench. Define emphasizes hands-on partnership—leveraging its network and expertise to help portfolio companies recruit talent, build strategic relationships, position in the market, and raise subsequent rounds of capital, while backing value-driven, principled leaders.
Source: firm website, verified Aug 3, 2026.
Team · 28 people
from the firm's website & public directories
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What they invest in
from 19 of 33 portfolio companiesHealthtech ×18Digital Health ×11AI & Machine Learning ×5SaaS ×5Data & Infrastructure ×4Enterprise Software ×3Developer Tools ×2AgTech ×1
HQs:United States×17Denmark×1
Investments · 33 tracked
founders shown can be your intro pathHealthtechEncinitas, US
Michael Hofner(Executive Officer)Avantika Waring(Executive Officer)Tom Richards(Director)Paul Geevarghese(Executive Officer)Bernhard Schandl(Executive Officer)Frank Westermann(Executive Officer, Director)
Board seatLynne Chou O'Keefe· per SEC Form D · $25.7M raise · filed Apr 2026
DexCare provides patient access and scheduling navigation logic for health systems, enabling patients to find available appointments across multiple care entry points and improving utilization of existing capacity.
HealthtechSaaSPhiladelphia, US
Board seatLynne Chou O'KeefeLynne Chou O?Keefe· per SEC Form D · $60M raise · filed Jun 2023
FOLX is a digital healthcare platform designed for LGBTQIA+ adults, providing inclusive and affirming medical care.
Digital HealthHealthtechBoston, US
A.G. Breitenstein(Founder)Lynne Chou O'Keefe(Director)Lena Ballantine(Executive Officer)Liana M Guzman Weis(Executive Officer, Director)Morgan Cheatham(Director)Lee Shapiro(Director)
Board seatLynne Chou O'KeefeLynne Chou-O'Keefe· per SEC Form D
HealthtechAtlanta, US
Selece Beasley(Executive Officer)Larry Graham(Executive Officer)Jeffrey Rhodes(Director)Nick Stengle(Executive Officer)Martin Longchamps(Director)Bruce Broussard(Director)
Board seatBruce Broussard· per SEC Form D · filed Aug 2020
El Segundo, US
Board seatLynne Chou O'Keefe· per SEC Form D · $20M raise · filed Feb 2024
Livongo offers a chronic condition management program combining connected health-monitoring devices (blood glucose meters, blood pressure monitors, scales), certified health coaches, and clinical support to help members manage diabetes, hypertension, and weight, including GLP-1 medication access.
Digital HealthHealthtechWellness & FitnessMountain View, US
JOSEPH E. CAREY(Executive Officer)BETH SEIDENBERG(Director)LEE SHAPIRO(Director)TOM MAIN(Director)BRIAN VANDENBERG(Executive Officer)HEMANT TANEJA(Director)
Board seatLynne Chou O'Keefe· per SEC Form D · $52.5M raise · filed Mar 2017
MedArrive provides software for scheduling, routing, and real-time tracking of in-home care delivery teams.
HealthtechLogistics & Supply ChainSaaSNew York, US
Agneta Breitenstein(Director)Inna Plumb(Executive Officer)William Sullivan(Director)Annie Case(Director)Daniel Trigub(Executive Officer, Director)Andy Harrison(Director)
Board seatA.G. BreitensteinLynne Chou O'Keefe· per SEC Form D
Boston, US
Adam Reich(Director)Walter Raymond Cooper(Executive Officer, Director, Promoter)Lynne Chou O'Keefe(Director)
Board seatLynne Chou O'Keefe· per SEC Form D · $4M raise · filed Jul 2025
Chicago, US
Robert Alan Knight(Executive Officer, Director)James Daryl Risinger(Executive Officer, Director)Christopher Elliot Brown(Executive Officer)Jared Dauman(Executive Officer)
BoardCaitlin Donovan(Director)Galym Imanbayev(Director)
Board seatLynne Chou O'Keefe· per SEC Form D · $54.2M raise · filed Dec 2024
Chicago, US
Board seatLynne Chou O'Keefe· per SEC Form D · $20M raise · filed Nov 2024
Cohere Health provides a clinical intelligence platform that integrates data across healthcare workflows including utilization management, payment integrity, appeals, care management, quality, and claims operations for enterprise healthcare organizations.
AI & Machine LearningEnterprise SoftwareHealthtechBoston, US
David Barrett(Director)Amir Debourou(Director)Siva Namasivayam(Executive Officer, Director)Gary L. Gottlieb(Director)Robert Shepardson(Executive Officer)Julian Harris(Director)
Concert Health is a behavioral health medical group that integrates behavioral health into primary care using the Collaborative Care Model, employing clinicians to treat patients and measure outcomes.
Digital HealthHealthtechMental Health
Crescendo Health provides a platform that helps clinical study participants assemble and securely store their complete health history and contribute it to medical research while controlling access to their data.
Data & InfrastructureDigital HealthHealthtech
San Francisco, US
David Hughes(Executive Officer, Director)Shruti Tibrewala(Executive Officer, Director)
Evermore Outcomes operates a benefits card and retailer network that lets health plans dynamically add, update, and reload supplemental benefits on a member's card.
Data & InfrastructureDigital HealthHealthtech
Plug-and-play conversational AI platform enabling voice and chat interactions with information across digital channels.
Israel Krush(Founder & CEO)
Workforce management solution transforming health system managers into exceptional leaders.
Newton, US
Russell Richmond, MD(Executive Officer, Director)Benedict Evans(Director)Kevin Kumler(Director)Constantine John Floros(Executive Officer, Director)Lisa Mastrangelo(Executive Officer)Mike Caffrey(Director)
Layer Health, an MIT spinout, builds AI tools using large language models to process clinical information in healthcare.
AI & Machine LearningDigital HealthHealthtechBoston, US
David A. Sontag(Executive Officer, Director)Lynne O'Keefe(Director)Anthony Philippakis(Director)
Luminai builds an AI-native operating system that unifies fragmented healthcare operational work streams to automate administrative and operational tasks across health systems.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareHealthtechSaaSSan Francisco, US
Kesava Kirupa Dinakaran(Founder)in
Marit is a free career platform for physicians and advanced practice providers (APPs) that offers crowdsourced, anonymous salary data and aggregated job listings from employers, associations, and job boards.
Digital HealthHealthtechHR Tech
Rob Anderson(Co-founder)
SanLuca is a clinician-first AI platform that integrates behavioral health into longitudinal chronic condition management for health systems and care teams.
AI & Machine LearningDigital HealthHealthtech
Tia is a healthcare platform that coordinates patient care by connecting care providers, clinical support, and care coordinators to manage appointments, prescriptions, billing, and procedures.
Digital HealthHealthtech
Carolyn Witte(Founder)
Unite Us provides a software and data infrastructure platform for coordinating whole-person care across healthcare, government, and community-based organizations, enabling need identification, service delivery coordination, and outcomes measurement at scale.
Data & InfrastructureGovTechHealthtech
Daniel M. Brillman(Executive Officer)
Verana Health aggregates de-identified clinical data from a network of over 20,000 physicians in ophthalmology, urology, and neurology to power real-world evidence, clinical trial enablement, and quality reporting for pharmaceutical companies and healthcare providers using AI and machine learning.
AI & Machine LearningData & InfrastructureDigital HealthHealthtech
Sujay Jadhav(Chief Executive Officer)
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does Define Ventures invest at?
- Define Ventures invests at the Pre-Seed, Seed, Series A, Series B, Series C stages.
- What is Define Ventures's typical check size?
- Define Ventures typically writes checks of $750K – $6M.
- What sectors does Define Ventures focus on?
- Define Ventures focuses on Digital Health, Healthtech.
- Where is Define Ventures located?
- Define Ventures is headquartered in San Francisco, US.
- Does Define Ventures lead rounds?
- Yes, Define Ventures leads investment rounds.
Media · Podcasts & interviews
featuring the teamDefine Ventures, Founder & Managing Partner, Lynne Chou O'Keefe
New York Stock Exchange · Lynne Chou O'Keefe
Founder Diversity is Increasing | Lynne Chou O'Keefe, Founder and Managing Partner, Define Ventures
Day Zero · Lynne Chou O'Keefe
Deciding to Start an Investment Firm | Lynne Chou O'Keefe, Define Ventures
Day Zero · Lynne Chou O'Keefe
Finding Her Calling | Lynne Chou O'Keefe, Founder and Managing Partner, Define Ventures
Day Zero · Lynne Chou O'Keefe
Meet the Hosts: Lynne Chou O'Keefe | Lynne Chou O'Keefe, Founder & Managing Partner, Define Ventures
Day Zero · Lynne Chou O'Keefe
The 'Always On' Nature of Entrepreneurs | Lynne Chou O'Keefe, Define Ventures
The Gary Bisbee Show · Lynne Chou O'Keefe
Images
Co-investors · 22
7wire Ventures builds and invests in early-stage digital health companies focused on empowering informed, connected health consumers.
GV (formerly Google Ventures) is a venture investment firm that backs founders across many industries, aiming to build long-term relationships and support companies across multiple stages and milestones.
Kleiner Perkins is a venture capital firm that backs founders across technology and life sciences, with a portfolio of companies from early stage through growth.
Flare Capital Partners is a venture capital firm specializing in healthcare technology, backing founders building software, data, and AI infrastructure for the healthcare industry.
Transformation Capital is an investment firm focused exclusively on the healthcare industry, backing companies transforming healthcare delivery and services.
Seae Ventures is an early-stage venture firm investing in healthcare companies that expand access to affordable, personalized care, with a focus on underserved populations and reducing health inequities.
General Catalyst is a venture capital and investment firm that backs founders across industries, with a strong focus on AI-driven transformation, fintech, healthcare, and other sectors.
Lightspeed Venture Partners is a global venture capital firm known for backing AI and technology founders, emphasizing deep, hands-on partnerships with the companies it funds.
Bessemer Venture Partners is a venture capital firm that partners with entrepreneurs from early stages through every stage of growth, publishing investment roadmaps across multiple technology sectors.
Khosla Ventures is a venture capital firm known for backing bold, contrarian bets in world-class teams that can reshape entire industries.
Sapphire Ventures is a venture capital firm founded in 2011 that backs technology companies, offering operating support such as executive talent and customer introductions to its portfolio.
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
▶10 more co-investors
Threshold VenturesKaiser Permanente VenturesFounders FundRed Swan Venturesxfactor venturesHighbury HoldingsBBG VenturesDragoneer Investment GroupVertical Venture PartnersFirst Close Partners
Firms observed investing alongside Define Ventures, from public investor directories. Shared companies are the overlap with Define Ventures's recorded portfolio.
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