Define Ventures
Venture capitalSan Francisco · Pre-Seed–Series C · 27 people tracked
Also known as DEFINE VENTURES MANAGEMENT, LLC
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Investment thesis
Define Ventures invests in early-stage health tech companies, backing entrepreneurs building category-defining businesses at the convergence of technology innovation, evolving consumer preferences, and structural shifts within the healthcare industry. The firm believes these trends will shape the future of healthcare for generations. It combines a curated team of founders, investors, and operators drawn from both Silicon Valley and healthcare, along with a deep advisor bench. Define emphasizes hands-on partnership—leveraging its network and expertise to help portfolio companies recruit talent, build strategic relationships, position in the market, and raise subsequent rounds of capital, while backing value-driven, principled leaders.
Source: firm website, verified Sep 15, 2026.
Team · 27 people
from the firm's website & curated & public directories
Founder mafia
The Define Ventures mafia →14 people who came through Define Ventures went on to found or lead other companies.
+ 2 more
What they invest in
from 30 of 41 portfolio companiesHealthtech ×25Digital Health ×22AI & Machine Learning ×10SaaS ×7Data & Infrastructure ×3Enterprise Software ×3Fintech ×3Wellness & Fitness ×3
HQs:United States×30
Investments · 41 tracked
founders shown can be your intro pathBy year:2026 · 32025 · 72024 · 52023 · 32022 · 32021 · 32020 · 12019 · 12018 · 12017 · 128 dated
DexCare provides a patient access platform that integrates search, navigation, and scheduling capabilities for healthcare systems.
AI & Machine LearningDigital HealthEnterprise SoftwareHealthtechSaaSProvidence, US
Sean O'Connor(Co-Founder & President)in
Co-investorsICONIQAllumia VenturesFrist Cressey VenturesTRANSFORMATION CAPITAL
Double Blind Bio builds AI agents that automate administrative workflows within clinical trial sites and sponsor operations, enabling faster and more efficient execution of clinical studies.
AI & Machine LearningHealthtechMedical DevicesSan Francisco, US
David Hughes(Executive Officer, Director)Shruti Tibrewala(Executive Officer, Director)
Co-investorsPeterson VenturesSignalFire
9amHealth provides virtual care for cardiometabolic conditions, offering weight management, diabetes care, and heart health treatment that combines prescription medication (including GLP-1s), lifestyle coaching, and lab testing.
Digital HealthHealthtechWellness & FitnessEncinitas, US
Frank Westermann(Executive Officer, Director)inAnton Kittelberger(Founder)inMichael Hofner(Executive Officer)inAvantika Waring(Executive Officer)Paul Geevarghese(Executive Officer)inBernhard Schandl(Executive Officer)in
Board seatLynne Chou O'Keefe· per SEC Form D
Co-investors7wire VenturesCalm/Storm VCCatalio Capital Management, LPHabitat PartnersHansmann Family OfficePUSH Ventures+2 more
DexCare provides patient access and scheduling navigation logic for health systems, enabling patients to find available appointments across multiple care entry points and improving utilization of existing capacity.
HealthtechSaaSPhiladelphia, US
Board seatLynne Chou O'KeefeLynne Chou O?Keefe· per SEC Form D · $60M raise · filed Jun 2023
Co-investorsFrist Cressey VenturesKaiser Permanente VenturesSPRINGROCK VENTURESTRANSFORMATION CAPITAL
FOLX is a digital healthcare platform designed for LGBTQIA+ adults, providing inclusive and affirming medical care.
Digital HealthHealthtechBoston, US
A.G. Breitenstein(Founder)inLena Ballantine(Executive Officer)inLiana M Guzman Weis(Executive Officer, Director)
BoardMorgan Cheatham(Director)inLee Shapiro(Director)in
Board seatLynne Chou O'KeefeLynne Chou-O'Keefe· per SEC Form D
Co-investors7wire VenturesBessemer Venture PartnersCorewell Health VenturesHabitat PartnersSeae VenturesBreyer Capital+2 more
Lightship provides clinical trial operations for biopharma companies, CROs, and academic institutions, offering site services, decentralized and hybrid trial models, patient recruitment, and mobile research units.
BiotechDigital HealthHealthtechEl Segundo, US
David MacMurchy(Chief Executive Officer)inMichael Shipton(Chief Business Officer)inDarcy Forman(Chief Operating Officer)inLindsay Van Pelt(Chief Medical Advisor)in
Board seatLynne Chou O'Keefe· per SEC Form D
Co-investorsHikma VenturesALLEGIS CAPITALAlumni VenturesCongruentCongruent VenturesHyperguap+5 more
Livongo offers a chronic condition management program combining connected health-monitoring devices (blood glucose meters, blood pressure monitors, scales), certified health coaches, and clinical support to help members manage diabetes, hypertension, and weight, including GLP-1 medication access.
Digital HealthHealthtechWellness & FitnessMountain View, US
JOSEPH E. CAREY(Executive Officer)BRIAN VANDENBERG(Executive Officer)MARIO CHRISTOPHER(Executive Officer)
BoardBETH SEIDENBERG(Board Director (Kleiner Perkins))inLEE SHAPIRO(Director)inHEMANT TANEJA(Director)in
Board seatLynne Chou O'Keefe· per SEC Form D · $52.5M raise · filed Mar 2017
Co-investors7wire VenturesCorewell Health VenturesGeneral CatalystHuman CapitalKleiner PerkinsSapphire Ventures+4 more
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MedArrive provides software for scheduling, routing, and real-time tracking of in-home care delivery teams.
HealthtechLogistics & Supply ChainSaaSNew York, US
Inna Plumb(Executive Officer)inDaniel Trigub(Executive Officer, Director)
BoardWilliam Sullivan(Director)Annie Case(Director)inAndy Harrison(Director)Agneta Breitenstein(Director)in
Board seatA.G. BreitensteinLynne Chou O'Keefe· per SEC Form D
Co-investors7wire VenturesCobalt VenturesCorewell Health VenturesDeclaration PartnersKleiner PerkinsLeaps by Bayer+2 more
MIGA is a multilateral organization that provides political risk insurance and credit guarantees to support private investment in developing countries.
FintechImpact & Social GoodInsurTechWashington, US
Walter Raymond Cooper(Executive Officer, Director, Promoter)Tsutomu Yamamoto(Managing Director)inJunaid Kamal Ahmad(Vice President, Operations)Ed Mountfield(Vice President and Chief Financial Officer)inAriane Di Iorio(Director, Economics and Sustainability)Muhamet Fall(Director for Industries)in
Board seatLynne Chou O'Keefe· per SEC Form D · $4M raise · filed Jul 2025
Co-investorsTrade and Development BankAdapt VenturesAlumni VenturesAsymmetric Capital PartnersFloating PointLux Capital+2 more
Chicago, US
Board seatLynne Chou O'Keefe· per SEC Form D
Co-investorsBlue Venture FundsGV (Google Ventures)Twine Ventures
Blackbird Health provides comprehensive neuroscience-based evaluations and coordinated mental healthcare for children, combining psychiatric assessment, therapy, and medication management to create personalized treatment plans.
Digital HealthHealthtechMental Health
Amy Edgar(Founder)
Co-investorsFrist Cressey VenturesGreyMatter
Cleveland Clinic is a multi-specialty medical group practice and hospital system founded in 1921, providing patient care, medical research, and education.
Digital HealthHealthtechMedical Devices
Co-investorsFred Hutchinson Cancer Research CenterGeneral CatalystPeak XV PartnersY Combinator
Cohere Health provides a platform aimed at aligning the interests of patients, physicians, and health plans to support care decisions and improve member outcomes.
AI & Machine LearningDigital HealthEnterprise SoftwareHealthtechSaaSBoston, US
Siva Namasivayam(Executive Officer, Director)inRobert Shepardson(Executive Officer)inKristen Carucci(Executive Officer)inDuncan Reese(Executive Officer)
BoardDavid Barrett(Director)Amir Debourou(Director)
Co-investorsCota CapitalFlare Capital PartnersLongitude CapitalDeerfield Management CompanyFlare Capital StrategiesPolaris Partners+1 more
Concert Health operates a behavioral health medical group providing integrated mental health treatment services within primary care settings such as family medicine, women's health, and pediatric offices.
Digital HealthHealthtechMental Health
Co-investorsK2 HealthVenturesTown Hall VenturesHealthy VenturesSierra VenturesVertical Venture Partners
Crescendo accelerates medical research by enabling clinical research participants to securely assemble and contribute their health data, while supporting patients with clinical care and safety consultations.
Data & InfrastructureDigital HealthHealthtech
Sam Roosz(Co-Founder, CEO)Michael Glassman(Co-Founder, President)
Evermore Outcomes operates a benefits card and retailer network that lets health plans dynamically add, update, and reload supplemental benefits on a member's card.
Data & InfrastructureDigital HealthHealthtech
Daryl Risinger(Founder)Jared D(Founder)Robby Knight(Founder)
Found offers clinically-led, personalized weight care that combines evidence-based medical treatment (including provider-prescribed medications) with support to help members lose weight and improve their health.
Digital HealthHealthtechWellness & Fitness
Co-investors1/1 CapitalAble PartnersAtomicIVP (Institutional Venture Partners)The Chernin Group (TCG Crypto)WestCap
Foundation Health offers an AI operating system for pharmacies that automates prior authorizations, refill authorizations, financial assistance enrollment, 340B compliance, and patient communications, along with a white-labeled digital pharmacy front door and a healthcare API.
AI & Machine LearningDigital HealthHealthtech
Umar Afridi(CEO & Founder)
Co-investorsCalm/Storm VCExceptional CapitalPage One VenturesTranspose Platform Management
Centivo is a primary-care-centered health plan administrator for self-funded employers, sold through benefits brokers and consultants.
Digital HealthHealthtechInsurTech
Alan Cohen(Founder)inAshok Subramanian(Founder & CEO)Stuart Roth(Founder)in
Co-investorsAlumni VenturesB Capital GroupB4 CapitalBasecamp FundF-Prime CapitalGPO Fund+5 more
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Healthier Capital is a venture capital firm that invests in technology-enabled healthcare companies seeking to reduce costs and improve care delivery.
Digital HealthFintechHealthtech
Amir Dan Rubin(CEO and Founding Managing Partner)in
Co-investorsModi VenturesBlack Opal VenturesHealthier CapitalMacquarie CapitalMaverick VenturesOncology Ventures+2 more
US direct-to-consumer telehealth company selling prescription and OTC treatments online by subscription; NYSE-listed as HIMS.
Jack Abraham(Co-founder)in
Co-investors7GC & Co8VCA-Rod CorpAtomicBrentwood AssociatesCAVU Consumer Partners+17 more
Plug-and-play conversational AI platform enabling voice and chat interactions with information across digital channels.
Israel Krush(Founder & CEO)inRom Cohen(Founder)in
Co-investorsBlack Opal VenturesDorm RoomEntrepreneurs Roundtable Accelerator (ERA)Hanaco Venture CapitalHealthier CapitalK20 Fund+7 more
Laudio builds a SaaS platform that supports frontline leaders in hospitals and health systems, using data and analytics to improve employee engagement, retention, and operational outcomes.
AI & Machine LearningDigital HealthHR TechSaaSNewton, US
Russell Richmond, MD(Executive Officer, Director)Tim Darling(Co-founder & President, Laudio Insights)inKevin Kumler(Director)Constantine John Floros(Executive Officer, Director)Lisa Mastrangelo(Executive Officer)Mike Caffrey(Director)
Co-investors.406 VenturesInHealth VenturesMemorialCare Innovation Fund
Layer Health builds AI tools for hospitals and health systems that automate clinical registry abstraction and custom quality-metric extraction across service lines such as cardiovascular, surgery, and oncology.
AI & Machine LearningDigital HealthHealthtechBoston, US
David A. Sontag(Executive Officer, Director)inLuke Murray(Founder)inDivya Gopinath(Founder)in
BoardLynne O'Keefe(Director)inAnthony Philippakis(Director)in
Co-investorsEast Post Road VenturesFlare Capital PartnersGV (Google Ventures)
Lightship designs and builds the AE.1, an all-electric travel trailer for the RV market.
CleantechDirect to ConsumerHardwareMobility & TransportationBroomfield, US
Tobias Kraus(Executive Officer, Director)Toby Kraus(Co-Founder & Chief Executive Officer)inBenjamin Parker(Founder)inHayley Cashdollar(Chief Operating Officer)inNick Herron(Chief Engineer)inRob Williams(Chief Creative Officer)in
Co-investorsClimacticCongruent VenturesHyperguapJetstreamObvious VenturesPrelude Ventures+5 more
Lightship Capital is a venture capital fund that invests in early-stage companies founded by underrepresented entrepreneurs, including founders of color, LGBTQ+ individuals, women, and innovators with disabilities.
AI & Machine LearningConsumerFintechImpact & Social GoodCincinnati, US
Candice Matthews Brackeen(General Partner)inBrian Brackeen(General Partner)in
Co-investorsAtento CapitalALLEGIS CAPITALAlumni VenturesCongruentCongruent VenturesHyperguap+5 more
Luminai builds an AI-native operating system that unifies fragmented healthcare operational work streams to automate administrative and operational tasks across health systems.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareHealthtechSaaSSan Francisco, US
Kesava Kirupa Dinakaran(Founder)inHarsh Gupta(Founder)
Co-investorsMoxxie VenturesPeak XV PartnersScribble VenturesShrug CapitalUnderscore VCWayfinder Ventures+4 more
Marit is a free career platform for physicians and advanced practice providers (APPs) that offers crowdsourced, anonymous salary data and aggregated job listings from employers, associations, and job boards.
Digital HealthHealthtechHR Tech
Rob Anderson(Co-founder)in
Co-investors25MadisonF-Prime CapitalReach Capital
SanLuca is a clinician-first AI platform that integrates behavioral health into longitudinal chronic condition management for health systems and care teams.
AI & Machine LearningDigital HealthHealthtech
Co-investorsSemperVirens Venture Capital
Tia is a healthcare platform that coordinates patient care by connecting care providers, clinical support, and care coordinators to manage appointments, prescriptions, billing, and procedures.
Digital HealthHealthtech
Carolyn Witte(Founder)in
Co-investorsACME CapitalCompoundHomebrewSeae VenturesThreshold VenturesTorch Capital+6 more
Unite Us provides software and data infrastructure for coordinating whole-person care, helping organizations identify social and health needs, deliver services, and track outcomes.
Digital HealthGovTechSaaSNew York, US
Daniel M. Brillman(Executive Officer)inTaylor Justice(Co-Founder and Chief Executive Officer)in
Co-investorsBlossom Street VenturesEqual Opportunity VenturesICONIQOak HC/FTOptum VenturesPLUS Capital+6 more
Verana Health aggregates de-identified clinical data from a network of over 20,000 physicians in ophthalmology, urology, and neurology to power real-world evidence, clinical trial enablement, and quality reporting for pharmaceutical companies and healthcare providers using AI and machine learning.
AI & Machine LearningData & InfrastructureDigital HealthHealthtechSan Francisco, US
Mark Blumenkranz, MD(Co-Founder, Verana Health and Lagunita Biosciences)Sujay Jadhav(Chief Executive Officer)in
Co-investorsNovo HoldingsBreyer CapitalTech Council VenturesValspring Capital
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Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Kentucky Homecare ParentSoda Health, Inc.Blackbird HealthEvermoreFair Square MedicareGro ClubHealthcare AI AutomationLiza HealthUpStream Care
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 2
1 IPOs · 1 acquisitions · showing 1Laudioacq. by Ascend Learning
Portfolio news
latest coverage across their companiesCleveland Clinic · cleveland.com · Sep 3, 2026
Hims & Hers · tradersunion.com · Aug 27, 2026
Double Blind Bio · trysignalbase.com · Aug 21, 2026
Healthier Capital · castleplacement.com · Jun 10, 2026
Luminai · healthcareittoday.com · Apr 23, 2026
Healthcare AI Automation · pulse2.com · Apr 9, 2026
Frequently asked questions
- How many investments has Define Ventures made?
- Define Ventures has 41 tracked investments, 2 of which have exited, including 12 dated in the last 24 months.
- What stage does Define Ventures invest at?
- Define Ventures invests at the Pre-Seed, Seed, Series A, Series B, Series C stages.
- What is Define Ventures's typical check size?
- Define Ventures typically writes checks of $750K – $6M.
- What sectors does Define Ventures focus on?
- Define Ventures focuses on Digital Health, Healthtech.
- Where is Define Ventures located?
- Define Ventures is headquartered in San Francisco, US.
- Does Define Ventures lead rounds?
- Yes, Define Ventures leads investment rounds.
- Who does Define Ventures co-invest with?
- Define Ventures most often shares deals with 7wire Ventures, Habitat Partners, Seae Ventures, among 33 tracked co-investors.
Media · Podcasts & interviews
featuring the teamDefine Ventures, Founder & Managing Partner, Lynne Chou O'Keefe
New York Stock Exchange · Lynne Chou O'Keefe
Founder Diversity is Increasing | Lynne Chou O'Keefe, Founder and Managing Partner, Define Ventures
Day Zero · Lynne Chou O'Keefe
Deciding to Start an Investment Firm | Lynne Chou O'Keefe, Define Ventures
Day Zero · Lynne Chou O'Keefe
Finding Her Calling | Lynne Chou O'Keefe, Founder and Managing Partner, Define Ventures
Day Zero · Lynne Chou O'Keefe
Meet the Hosts: Lynne Chou O'Keefe | Lynne Chou O'Keefe, Founder & Managing Partner, Define Ventures
Day Zero · Lynne Chou O'Keefe
The 'Always On' Nature of Entrepreneurs | Lynne Chou O'Keefe, Define Ventures
The Gary Bisbee Show · Lynne Chou O'Keefe
Images
Co-investors · 22
7wire Ventures builds and invests in early-stage digital health companies focused on empowering informed, connected health consumers.
General Catalyst is a venture capital firm operating as a partnership focused on company building and accelerating the growth of the businesses it backs.
GV (Google Ventures) is a venture capital firm that has invested in artificial intelligence and machine learning since its early days, building a global portfolio of more than 100 AI companies across infrastructure, life sciences, and applications.
Kleiner Perkins is a venture capital firm that backs founders across technology and life sciences, from early stage through growth.
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
Threshold Ventures is a venture capital firm that partners with founder-led companies at inflection points of breakout growth, engaging early and providing hands-on advice during moments of market transformation.
Flare Capital Partners is a healthcare technology-focused venture firm that partners with founders building companies to improve outcomes, lower costs, and reshape healthcare delivery.
Transformation Capital is an investment firm focused exclusively on the healthcare industry, backing companies transforming healthcare delivery and services.
Seae Ventures is an early-stage venture firm investing in healthcare companies that expand access to affordable, personalized care, with a focus on underserved populations and reducing health inequities.
Founders Fund is a venture capital firm that backs technology companies building transformative products.
Lightspeed is a global venture capital firm that has spent over two decades backing innovative companies as an early and first investor.
Bessemer Venture Partners is a global venture capital firm that partners with entrepreneurs across enterprise, consumer, and healthcare sectors from early stages through growth.
▶10 more co-investors
Khosla VenturesSapphire VenturesHighbury HoldingsVertical Venture PartnersKaiser Permanente VenturesRed Swan Venturesxfactor venturesBBG VenturesDragoneer Investment GroupFirst Close Partners
Firms observed investing alongside Define Ventures, from public investor directories. Shared companies are the overlap with Define Ventures's recorded portfolio.
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