Define Ventures
Venture capitalSan Francisco · Pre-Seed–Series C · 27 people tracked
Also known as DEFINE VENTURES MANAGEMENT, LLC
Investment thesis
Define Ventures invests in early-stage health tech companies, backing entrepreneurs building category-defining businesses at the convergence of technology innovation, evolving consumer preferences, and structural shifts within the healthcare industry. The firm believes these trends will shape the future of healthcare for generations. It combines a curated team of founders, investors, and operators drawn from both Silicon Valley and healthcare, along with a deep advisor bench. Define emphasizes hands-on partnership—leveraging its network and expertise to help portfolio companies recruit talent, build strategic relationships, position in the market, and raise subsequent rounds of capital, while backing value-driven, principled leaders.
Source: firm website, verified Aug 25, 2026.
Team · 27 people
from the firm's website & curated & public directories
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Founder mafia
The Define Ventures mafia →10 people who came through Define Ventures went on to found or lead other companies.
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What they invest in
from 23 of 31 portfolio companiesHealthtech ×21Digital Health ×19AI & Machine Learning ×7SaaS ×7Data & Infrastructure ×3Enterprise Software ×2HR Tech ×2Mental Health ×2
HQs:United States×22
Investments · 31 tracked
founders shown can be your intro pathBy year:2026 · 22025 · 32024 · 42023 · 22021 · 12019 · 12018 · 12017 · 115 dated
9amHealth provides virtual care for cardiometabolic conditions, offering weight management, diabetes care, and heart health treatment that combines prescription medication (including GLP-1s), lifestyle coaching, and lab testing.
Digital HealthHealthtechWellness & FitnessEncinitas, US
Frank Westermann(Executive Officer, Director)Anton Kittelberger(Founder)inMichael Hofner(Executive Officer)Avantika Waring(Executive Officer)Paul Geevarghese(Executive Officer)Bernhard Schandl(Executive Officer)
Board seatLynne Chou O'Keefe· per SEC Form D
Co-investors7wire VenturesCalm/Storm VCCatalio Capital Management, LPHabitat PartnersHansmann Family OfficePUSH Ventures+1 more
DexCare provides patient access and scheduling navigation logic for health systems, enabling patients to find available appointments across multiple care entry points and improving utilization of existing capacity.
HealthtechSaaSPhiladelphia, US
Board seatLynne Chou O'KeefeLynne Chou O?Keefe· per SEC Form D · $60M raise · filed Jun 2023
Co-investorsFrist Cressey VenturesKaiser Permanente VenturesSPRINGROCK VENTURESTRANSFORMATION CAPITAL
FOLX is a digital healthcare platform designed for LGBTQIA+ adults, providing inclusive and affirming medical care.
Digital HealthHealthtechBoston, US
A.G. Breitenstein(Founder)inLena Ballantine(Executive Officer)Liana M Guzman Weis(Executive Officer, Director)
BoardMorgan Cheatham(Director)inLee Shapiro(Director)in
Board seatLynne Chou O'KeefeLynne Chou-O'Keefe· per SEC Form D
Co-investors7wire VenturesBessemer Venture PartnersCorewell Health VenturesHabitat PartnersSeae VenturesBreyer Capital+2 more
HealthtechAtlanta, US
Selece Beasley(Executive Officer)Larry Graham(Executive Officer)Jeffrey Rhodes(Director)Nick Stengle(Executive Officer)Martin Longchamps(Director)Christine Spadafor(Director)
Board seatBruce Broussard· per SEC Form D · filed Aug 2020
Lightship provides clinical trial operations for biopharma companies, CROs, and academic institutions, offering site services, decentralized and hybrid trial models, patient recruitment, and mobile research units.
BiotechDigital HealthHealthtechEl Segundo, US
David MacMurchy(Chief Executive Officer)inMichael Shipton(Chief Business Officer)inDarcy Forman(Chief Operating Officer)inLindsay Van Pelt(Chief Medical Advisor)in
Board seatLynne Chou O'Keefe· per SEC Form D
Co-investorsHikma VenturesALLEGIS CAPITALAlumni VenturesCongruentCongruent VenturesHyperguap+3 more
Livongo offers a chronic condition management program combining connected health-monitoring devices (blood glucose meters, blood pressure monitors, scales), certified health coaches, and clinical support to help members manage diabetes, hypertension, and weight, including GLP-1 medication access.
Digital HealthHealthtechWellness & FitnessMountain View, US
JOSEPH E. CAREY(Executive Officer)BRIAN VANDENBERG(Executive Officer)MARIO CHRISTOPHER(Executive Officer)
BoardBETH SEIDENBERG(Board Director (Kleiner Perkins))inLEE SHAPIRO(Director)inHEMANT TANEJA(Director)in
Board seatLynne Chou O'Keefe· per SEC Form D · $52.5M raise · filed Mar 2017
Co-investors7wire VenturesCorewell Health VenturesGeneral CatalystHuman CapitalKleiner PerkinsSapphire Ventures+4 more
MedArrive provides software for scheduling, routing, and real-time tracking of in-home care delivery teams.
HealthtechLogistics & Supply ChainSaaSNew York, US
Inna Plumb(Executive Officer)Daniel Trigub(Executive Officer, Director)
BoardWilliam Sullivan(Director)Annie Case(Director)inAndy Harrison(Director)Agneta Breitenstein(Director)in
Board seatA.G. BreitensteinLynne Chou O'Keefe· per SEC Form D
Co-investors7wire VenturesCobalt VenturesCorewell Health VenturesDeclaration PartnersKleiner PerkinsSection 32
Boston, US
Walter Raymond Cooper(Executive Officer, Director, Promoter)
BoardAdam Reich(Director)
Board seatLynne Chou O'Keefe· per SEC Form D · $4M raise · filed Jul 2025
Co-investorsQuiet Capital
Chicago, US
Robert Alan Knight(Executive Officer, Director)Christopher Elliot Brown(Executive Officer)Jared Dauman(Executive Officer)James Daryl Risinger(Executive Officer, Director)
BoardCaitlin Donovan(Director)Galym Imanbayev(Director)in
Board seatLynne Chou O'Keefe· per SEC Form D · $54.2M raise · filed Dec 2024
Co-investorsLightspeed Venture PartnersQiming Healthcare
Chicago, US
Board seatLynne Chou O'Keefe· per SEC Form D
Co-investorsBlue Venture FundsGV (Google Ventures)Twine Ventures
Blackbird Health provides pediatric mental health care, offering whole-child assessments, therapy and skill building, and psychiatric and medication support for children, teens, young adults, and parents.
Digital HealthHealthtechMental Health
Co-investorsFrist Cressey VenturesGreyMatter
Cohere Health provides a platform aimed at aligning the interests of patients, physicians, and health plans to support care decisions and improve member outcomes.
AI & Machine LearningDigital HealthEnterprise SoftwareHealthtechSaaSBoston, US
Siva Namasivayam(Executive Officer, Director)Robert Shepardson(Executive Officer)Kristen Carucci(Executive Officer)Duncan Reese(Executive Officer)
BoardDavid Barrett(Director)Amir Debourou(Director)
Co-investorsCota CapitalFlare Capital PartnersLongitude CapitalDeerfield Management CompanyFlare Capital StrategiesTemasek
Concert Health is a behavioral health medical group that integrates behavioral health into primary care using the Collaborative Care Model, employing clinicians to treat patients and measure outcomes.
Digital HealthHealthtechMental Health
Co-investorsK2 HealthVentures
San Francisco, US
David Hughes(Executive Officer, Director)Shruti Tibrewala(Executive Officer, Director)
Evermore Outcomes operates a benefits card and retailer network that lets health plans dynamically add, update, and reload supplemental benefits on a member's card.
Data & InfrastructureDigital HealthHealthtech
Daryl Risinger(Founder)Jared D(Founder)Robby Knight(Founder)
Foundation Health offers an AI operating system for pharmacies that automates prior authorizations, refill authorizations, financial assistance enrollment, 340B compliance, and patient communications, along with a white-labeled digital pharmacy front door and a healthcare API.
AI & Machine LearningDigital HealthHealthtech
Umar Afridi(CEO & Founder)
Co-investorsPage One VenturesTranspose Platform Management
San Francisco, US
Justin Mardjuki(Executive Officer, Director)
BoardAndrew Smith(Director)Rick Newell(Director)
Co-investorsPeak XV Partners
Centivo is a primary-care-centered health plan administrator for self-funded employers, sold through benefits brokers and consultants.
Digital HealthHealthtechInsurTech
Alan Cohen(Founder)inAshok Subramanian(Founder & CEO)Stuart Roth(Founder)in
Co-investorsAlumni VenturesB Capital GroupB4 CapitalBasecamp FundF-Prime CapitalGPO Fund+5 more
US direct-to-consumer telehealth company selling prescription and OTC treatments online by subscription; NYSE-listed as HIMS.
Jack Abraham(Co-founder)in
Co-investors7GC & Co8VCA-Rod CorpAtomicBrentwood AssociatesCAVU Consumer Partners+16 more
Plug-and-play conversational AI platform enabling voice and chat interactions with information across digital channels.
Israel Krush(Founder & CEO)Rom Cohen(Founder)in
Co-investorsBlack Opal VenturesDorm RoomEntrepreneurs Roundtable Accelerator (ERA)Hanaco Venture CapitalHealthier CapitalK20 Fund+7 more
Laudio builds a SaaS platform that supports frontline leaders in hospitals and health systems, using data and analytics to improve employee engagement, retention, and operational outcomes.
AI & Machine LearningDigital HealthHR TechSaaSNewton, US
Russell Richmond, MD(Executive Officer, Director)Tim Darling(Co-founder & President, Laudio Insights)inKevin Kumler(Director)Constantine John Floros(Executive Officer, Director)Lisa Mastrangelo(Executive Officer)Mike Caffrey(Director)
Co-investors.406 VenturesInHealth VenturesMemorialCare Innovation Fund
Layer Health builds AI tools for hospitals and health systems that automate clinical registry abstraction and custom quality-metric extraction across service lines such as cardiovascular, surgery, and oncology.
AI & Machine LearningDigital HealthHealthtechBoston, US
David A. Sontag(Executive Officer, Director)Luke Murray(Founder)inDivya Gopinath(Founder)in
BoardLynne O'Keefe(Director)Anthony Philippakis(Director)in
Co-investorsEast Post Road VenturesFlare Capital PartnersGV (Google Ventures)
Co-investorsNew Enterprise Associates (NEA)
Luminai builds an AI-native operating system that unifies fragmented healthcare operational work streams to automate administrative and operational tasks across health systems.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareHealthtechSaaSSan Francisco, US
Kesava Kirupa Dinakaran(Founder)inHarsh Gupta(Founder)
Co-investorsMoxxie VenturesPeak XV PartnersScribble VenturesShrug CapitalUnderscore VCWayfinder Ventures+4 more
Marit is a free career platform for physicians and advanced practice providers (APPs) that offers crowdsourced, anonymous salary data and aggregated job listings from employers, associations, and job boards.
Digital HealthHealthtechHR Tech
Rob Anderson(Co-founder)
Co-investors25Madison
SanLuca is a clinician-first AI platform that integrates behavioral health into longitudinal chronic condition management for health systems and care teams.
AI & Machine LearningDigital HealthHealthtech
Co-investorsSemperVirens Venture Capital
Tia is a healthcare platform that coordinates patient care by connecting care providers, clinical support, and care coordinators to manage appointments, prescriptions, billing, and procedures.
Digital HealthHealthtech
Carolyn Witte(Founder)
Co-investorsACME CapitalCompoundHomebrewSeae VenturesThreshold VenturesTorch Capital+6 more
Unite Us provides software and data infrastructure for coordinating whole-person care, helping organizations identify social and health needs, deliver services, and track outcomes.
Digital HealthGovTechSaaSNew York, US
Daniel M. Brillman(Executive Officer)Taylor Justice(Co-Founder and Chief Executive Officer)
Co-investorsBlossom Street VenturesEqual Opportunity VenturesICONIQOak HC/FTOptum VenturesPLUS Capital+6 more
Verana Health aggregates de-identified clinical data from a network of over 20,000 physicians in ophthalmology, urology, and neurology to power real-world evidence, clinical trial enablement, and quality reporting for pharmaceutical companies and healthcare providers using AI and machine learning.
AI & Machine LearningData & InfrastructureDigital HealthHealthtech
Sujay Jadhav(Chief Executive Officer)
Co-investorsNovo HoldingsBreyer CapitalTech Council VenturesValspring Capital
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 1
IPOs and acquisitions across the tracked portfolioLaudioacq. by Ascend Learning
Portfolio news
latest coverage across their companiesHims & Hers · tradersunion.com · Aug 27, 2026
Double Blind Bio · trysignalbase.com · Aug 21, 2026
Luminai · healthcareittoday.com · Apr 23, 2026
Healthcare AI Automation · pulse2.com · Apr 9, 2026
MedArrive · homehealthcarenews.com · Mar 19, 2026
Hyro · tech.cornell.edu · Dec 19, 2025
Frequently asked questions
- What stage does Define Ventures invest at?
- Define Ventures invests at the Pre-Seed, Seed, Series A, Series B, Series C stages.
- What is Define Ventures's typical check size?
- Define Ventures typically writes checks of $750K – $6M.
- What sectors does Define Ventures focus on?
- Define Ventures focuses on Digital Health, Healthtech.
- Where is Define Ventures located?
- Define Ventures is headquartered in San Francisco, US.
- Does Define Ventures lead rounds?
- Yes, Define Ventures leads investment rounds.
- Who does Define Ventures co-invest with?
- Define Ventures most often shares deals with 7wire Ventures, Bessemer Venture Partners, Corewell Health Ventures, among 5 tracked co-investors.
Media · Podcasts & interviews
featuring the teamDefine Ventures, Founder & Managing Partner, Lynne Chou O'Keefe
New York Stock Exchange · Lynne Chou O'Keefe
Founder Diversity is Increasing | Lynne Chou O'Keefe, Founder and Managing Partner, Define Ventures
Day Zero · Lynne Chou O'Keefe
Deciding to Start an Investment Firm | Lynne Chou O'Keefe, Define Ventures
Day Zero · Lynne Chou O'Keefe
Finding Her Calling | Lynne Chou O'Keefe, Founder and Managing Partner, Define Ventures
Day Zero · Lynne Chou O'Keefe
Meet the Hosts: Lynne Chou O'Keefe | Lynne Chou O'Keefe, Founder & Managing Partner, Define Ventures
Day Zero · Lynne Chou O'Keefe
The 'Always On' Nature of Entrepreneurs | Lynne Chou O'Keefe, Define Ventures
The Gary Bisbee Show · Lynne Chou O'Keefe
Images
Co-investors · 22
7wire Ventures builds and invests in early-stage digital health companies focused on empowering informed, connected health consumers.
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General Catalyst is a venture capital firm operating as a partnership focused on company building and accelerating the growth of the businesses it backs.
GV (Google Ventures) is a venture capital firm that has invested in artificial intelligence and machine learning since its early days, building a global portfolio of more than 100 AI companies across infrastructure, life sciences, and applications.
Kleiner Perkins is a venture capital firm that backs founders across technology and life sciences, from early stage through growth.
Threshold Ventures is a venture capital firm that partners with founder-led companies at inflection points of breakout growth, engaging early and providing hands-on advice during moments of market transformation.
Flare Capital Partners is a healthcare technology-focused venture firm that partners with founders building companies to improve outcomes, lower costs, and reshape healthcare delivery.
Transformation Capital is an investment firm focused exclusively on the healthcare industry, backing companies transforming healthcare delivery and services.
Seae Ventures is an early-stage venture firm investing in healthcare companies that expand access to affordable, personalized care, with a focus on underserved populations and reducing health inequities.
Lightspeed is a global venture capital firm that has spent over two decades backing innovative companies as an early and first investor.
Bessemer Venture Partners is a global venture capital firm that partners with entrepreneurs across enterprise, consumer, and healthcare sectors from early stages through growth.
Sapphire Ventures partners with expansion-stage enterprise software companies aiming to become category leaders.
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
▶10 more co-investors
Kaiser Permanente VenturesFounders FundKhosla VenturesRed Swan Venturesxfactor venturesHighbury HoldingsBBG VenturesDragoneer Investment GroupVertical Venture PartnersFirst Close Partners
Firms observed investing alongside Define Ventures, from public investor directories. Shared companies are the overlap with Define Ventures's recorded portfolio.
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