🦊/Companies

Fractyl

NASDAQ: GUTS

Lexington, US · Founded 2010 · Delaware corporation · 106 employees on LinkedIn · 9 known investors

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532 people in our graph share verified history with the Fractyl team — schools, employers, funds. One of them is your warm intro.

Fractyl develops therapies for obesity and type 2 diabetes, focusing on non-drug-based approaches rooted in understanding metabolic disease mechanisms. The company serves patients and the physician community seeking alternatives to lifelong pharmaceutical treatments.

Founders & leadership

Fractyl was founded in 2010 by HARITH RAJAGOPALAN, JAY CAPLAN, Jay Caplan, and Harith Rajagopalan.

HRHARITH RAJAGOPALAN
HARITH RAJAGOPALANinCo-Founder and CEOHarith Rajagopalan holds an M.D. and Ph.D. from Johns Hopkins School of Medicine and a B.S. in chemistry from Stanford University. Before co-founding Fractyl Health, he trained as a cardiologist and physician-scientist at Brigham and Women's Hospital and Harvard Stem Cell Institute, and conducted research on intestinal cancers published in major medical journals.
JCJAY CAPLAN
JAY CAPLANinCo-founder and President
JCJay Caplan
Jay CaplaninCo-founder and President
HRHarith Rajagopalan
Harith Rajagopalanin𝕏Co-Founder and CEOHarith Rajagopalan, M.D., Ph.D., is co-founder and CEO of Fractyl Health, which he started while an Entrepreneur-in-Residence at General Catalyst Partners; he was previously an academic cardiologist and physician-scientist. He holds a B.S. in chemistry from Stanford University, earned M.D. and Ph.D. degrees at Johns Hopkins School of Medicine where he researched intestinal cancers, trained in internal medicine and clinical cardiology at Brigham and Women's Hospital, and completed a research fellowship at the Harvard Stem Cell Institute.
LDLISA DAVIDSON
LISA DAVIDSONinChief Financial Officer2015–2025Senior finance executive with experience scaling biotech, medtech, and specialty pharma companies from early development through IPO and public growth; previously held CFO roles and led over $1B in combined equity and debt financings across multiple life sciences organizations.
DM
Diane MarcouinConsulting CFO2012–2015

Board

AW
Allan WillinChair of the Board of Directors2012–2024Executive Chair at EBR Systems
NSNimesh Shah
Nimesh ShahinChief Business Officer2016–2017Managing Director at K2 HealthVentures
CG
Christopher GabrieliBoard director
ARAjay Royan
Ajay RoyaninBoard directorInvestor at Mithril Capital Management
SL
Stanley LapidusBoard director

Investors · 9

Reported raises · per SEC filings

Form D private placements

$275.7M disclosed across 6 rounds · 2014–2022

$20.1MraisedJan 2022 · 4 investors · Other
Rule 506(b)
Officers, directors & promoters on the filing
  • ALLAN WILLDirector
  • JUAN CARLOS LOPEZ-TALAVERAExecutive Officer
  • CLIVE MEANWELLDirector
  • LISA DAVIDSONExecutive Officer
  • HARITH RAJAGOPALANExecutive Officer, Director
  • WILLIAM BRADLEYDirector
  • BRIAN DOVEYDirector
  • KELLY BARNESDirector
  • AMY SCHULMANDirector
  • JAY CAPLANExecutive Officer
  • MARC ELIADirector
  • AJAY ROYANDirector
Offering amount
$20.1M
Amount sold
$20.1M
First sale
Jan 2022
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
$100MraisedJun 2021 · 15 investors · Other Health Care
Rule 506(b)
Officers, directors & promoters on the filing
  • WILLIAM BRADLEYDirector
  • JUAN CARLOS LOPEZ-TALAVERAExecutive Officer
  • ALLAN WILLDirector
  • CLIVE MEANWELLDirector
  • MARGARET BORYSExecutive Officer
  • JAY CAPLANExecutive Officer
  • MICHAEL HUANGDirector
  • LISA DAVIDSONExecutive Officer
  • MARC ELIADirector
  • HARITH RAJAGOPALANExecutive Officer, Director
  • BRIAN DOVEYDirector
  • AJAY ROYANDirector
  • AMY SCHULMANDirector
Offering amount
$100M
Amount sold
$100M
First sale
Jun 2021
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
$44.8MraisedMar 2020 · 15 investors · Other Health Care
Rule 506(b)
Officers, directors & promoters on the filing
  • WILLIAM BRADLEYDirector
  • AMY SCHULMANDirector
  • JUAN CARLOS LOPEZ-TALAVERAExecutive Officer
  • HARITH RAJAGOPALANExecutive Officer, Director
  • JAY CAPLANExecutive Officer
  • MARGARET BORYSExecutive Officer
  • LISA DAVIDSONExecutive Officer
  • JOHN AMATRUDADirector
  • CHRISTOPHER GABRIELIDirector
  • STANLEY LAPIDUSDirector
  • AJAY ROYANDirector
  • BRIAN DOVEYDirector
  • ALLAN WILLDirector
Offering amount
$44.8M
Amount sold
$44.8M
Finders' fees
$468K
First sale
Mar 2020
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
$44MraisedDec 2017 · 19 investors · Other Health Care
Rule 506(b)
Officers, directors & promoters on the filing
  • STANLEY LAPIDUSDirector
  • HARITH RAJAGOPALANExecutive Officer, Director
  • CHRISTOPHER GABRIELIDirector
  • LISA DAVIDSONExecutive Officer
  • AJAY ROYANDirector
  • JOHN AMATRUDADirector
  • ALLAN WILLDirector
  • BRIAN DOVEYDirector
  • JAY CAPLANExecutive Officer
  • WILLIAM BRADLEYDirector
Offering amount
$44M
Amount sold
$44M
Finders' fees
$250K
First sale
Jun 2017
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
$47.2MraisedFeb 2016 · 16 investors · Other Health Care
Rule 506(b)
Officers, directors & promoters on the filing
  • ALLAN WILLDirector
  • STANLEY LAPIDUSDirector
  • NIMESH SHAHDirector
  • CHRISTOPHER GABRIELIDirector
  • AJAY ROYANDirector
  • HARITH RAJAGOPALANExecutive Officer, Director
  • JAY CAPLANExecutive Officer, Director
  • LISA DAVIDSONExecutive Officer
Offering amount
$47.2M
Amount sold
$47.2M
First sale
Oct 2015
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
$19.8MraisedSep 2014 · 13 investors · Other Health Care
Rule 506(b)
Officers, directors & promoters on the filing
  • Ajay RoyanDirector
  • Christopher GabrieliDirector
  • Jay CaplanExecutive Officer, Director
  • Diane MarcouExecutive Officer
  • Allan WillDirector
  • Harith RajagopalanExecutive Officer, Director
  • Stanley LapidusDirector
  • Nimesh ShahDirector
Offering amount
$48.6M
Amount sold
$19.8M
First sale
Aug 2014
Incorporated
Corporation, Delaware, 2010
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

Competitors · 2

by search overlap

Companies competing with Fractyl for the same Google search keywords, organic and paid, via search-intersection analysis.

In the news

Frequently asked questions

What does Fractyl do?
Fractyl develops therapies for obesity and type 2 diabetes, focusing on non-drug-based approaches rooted in understanding metabolic disease mechanisms. The company serves patients and the physician community seeking alternatives to lifelong pharmaceutical treatments.
Who founded Fractyl?
Fractyl was founded by HARITH RAJAGOPALAN, JAY CAPLAN, Jay Caplan, Harith Rajagopalan in 2010.
Who are Fractyl's investors?
Fractyl's investors include Bessemer Venture Partners, Catalio Capital Management, LP, Emergent Medical Partners, LLP, Mithril Capital Management, Domain Associates, General Catalyst, MITHRIL, Polaris Partners and 1 more.
How much funding has Fractyl raised?
Fractyl has disclosed $275.7M raised across 6 rounds.
Where is Fractyl headquartered?
Fractyl is headquartered in Lexington, US.