Two Sigma Ventures — 2021 Investments
14 investments dated 2021 · listed companies and verified rows first · show all
Hyper provides avatar and AI storytelling tools that enable consumers to create their own content and experiences, positioning itself in the creator economy space.
AI & Machine LearningConsumerCreator EconomyMedia & EntertainmentSocialSan Francisco, US
Aaron Ng(CEO)inLevanJimAndrew Breckenridge(Executive Officer, Director)
Co-investorsY CombinatorMakers Fund1337.fundAmazon Alexa FundSequoia Capital
Odeko provides software and operational systems for independent food service businesses to compete with chain restaurants through cost optimization and margin improvement.
Enterprise SoftwareFoodTechLogistics & Supply ChainRetail TechSaaSNew York City, US
James Burkhardt(Founder)inDane Atkinson(CEO)inTom Hore(Chief Product Officer)inStephen Mar(Chief Legal & Administrative Officer)inTodd Sunsted(Executive Officer)Bernar Bekirov(Executive Officer)in
Board seatDan Abelon· per SEC Form D
Co-investorsAlumni VenturesB Capital GroupB4 CapitalBoxGroupEmles Venture PartnersFirst Round Capital+29 more
Comet builds infrastructure for developing, evaluating, and deploying AI applications in production.
AI & Machine LearningData & InfrastructureDeveloper ToolsNew York City, US
Gideon Mendels(Founder)inNimrod Lahav(Founder)inDishant Daryani(Founder)Utkarsh Gupta(Founder)
Co-investorsElevation CapitalGiTV, Inc.Invest In DataScale Venture PartnersTechstarsTrilogy Equity Partners+4 more
Cylera provides a healthcare cybersecurity platform focused on connected medical devices, IoT, and IT assets, giving hospitals and health systems visibility, risk assessment, and threat detection across their environments.
CybersecurityHealthtechIoTNew York, US
Timur Ozekcin(Executive Officer, Director)inSean Abraham(Executive Officer, Director)inApostolos Bakoyiannis(Executive Officer)Owen Wilson(Director)
Co-investorsAlumni VenturesContour Venture PartnersDreamit VenturesEpsilon Health InvestorsFrontier Path VCGaingels+8 more
Facet provides personal financial planning and investment management, using diversified low-cost, tax-efficient ETF portfolios paired with a dedicated CFP professional.
ConsumerFintechSaaSBaltimore, US
ANDERSON JONES(Executive Officer, Director, Promoter)Anders Jones(Founder)inPatrick McKenna(Founder)inPAUL MARTIN(Executive Officer)inSHRUTI JOSHI(Executive Officer)inDARSHAN PATEL(Executive Officer)in
Co-investorsAccelerator VenturesMultiplier CapitalWarburg PincusAccelBasis Set VenturesDurable Capital Partners+4 more
Hexagon Bio develops novel payload mechanisms for antibody-drug conjugates (ADCs) aimed at overcoming resistance to current cancer treatments and expanding ADC indications.
BiotechDeep TechHealthtechMenlo Park, US
Colin James Bell Harvey(Director)Brian T. Naughton(Director)inMaureen Hillenmeyer(CEO & Co-Founder)in
BoardAlex Kolich(Director)
Co-investorsATEL VenturesB3 HoldingNextech InvestSoftBank Vision FundThe Column Group8VC+1 more
insitro is a drug discovery and development company that uses machine learning and cellular data to identify therapeutic insights and accelerate the creation of new medicines.
AI & Machine LearningBiotechSouth San Francisco, US
Daphne Koller(Founder)inDuane Valz(General Counsel)inMary Rozenman(Chief Financial Officer)in
BoardRobert Nelsen(Director)Vijay Pande(Director)in
Co-investorsAndreessen HorowitzARCH Venture PartnersDeviation CapitalForesite CapitalGV (Google Ventures)HOF Capital+9 more
Mio provides interoperability across collaboration platforms, enabling users to send messages, manage identities, share files, and initiate meetings across different systems.
Developer ToolsEnterprise SoftwareSaaSAustin, US
Tom Hadfield(CEO)inJames Cundle(CTO)in
Co-investorsCisco InvestmentsEniac VenturesNewtown PartnersY CombinatorCapital FactoryFour Cities+10 more
Nelo offers a mobile credit app for consumers in Mexico, letting users get approved for credit and pay in biweekly installments.
ConsumerFintechMexico City, MX
Kyle Miller(Founder)inStephen Hebson(Founder)in
Co-investorsEastward Capital PartnersGaingelsHomebrewTop Corner CapitalAnthony PomplianoGokul Rajaram+4 more
Per Diem builds a mobile app builder designed for local restaurant and coffee shop owners to compete with larger chains by turning customers into loyal patrons.
ConsumerEnterprise SoftwareMarketing TechRetail TechSaaSNew York City, US
Tomer Molovinsky(Founder)inDoron Segal(Founder)inRachel Segal(Head of People)
Co-investorsY CombinatorDecent CapitalDnx VenturesShare Ventures
Text Blaze is a productivity tool that creates text snippets and templates to reduce repetitive typing across web applications.
Developer ToolsEnterprise SoftwareFuture of WorkSaaSSan Francisco, US
Dan Barak(Founder)inScott Fortmann-Roe(Founder)inGaurang Tandon(Engineer)
Co-investorsFourth RealmY CombinatorBossa InvestFoley VenturesGlobal Founders CapitalParadox Capital+1 more
Tiger Data, creators of TimescaleDB, builds a Postgres-based time-series database for fast ingest, efficient storage, and real-time analytics at scale.
Cloud ComputingData & InfrastructureDeveloper ToolsEnterprise SoftwareIoTNew York, US
Ajay Kulkarni(Founder)inMikeinMichael J. Freedman(Co-founder and Chief Technology Officer)inRahil Sondhi(Founder of acquired PopSQL; joined Timescale in 2024)inKerri Damm(Chief Financial Officer)inRamon Guiu(Vice President, Product)in
Co-investorsIcon VenturesNew Enterprise Associates (NEA)Redpoint VenturesBenchmarkTiger Global Management
Weights & Biases is an AI developer platform that enables teams to build, train, and monitor AI agents, applications, and models with tools for experiment tracking, model management, and agent evaluation.
AI & Machine LearningData & InfrastructureDeveloper ToolsSan Francisco, US
Shawn Lewis(Founder)inLukas Biewald(Founder)inChris Van Pelt(Founder)inMariah Nagy(Executive Officer)inYan-David Erlich(Executive Officer)inCameron Kinloch(Executive Officer)in
Co-investorsAIX VenturesBond Capital ManagementBrighter CapitalBrilliant Phoenix CapitalCoatue ManagementDiagram Capital+42 more
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Per Diem Subscriptions, Inc.
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.













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