.406 Ventures
Venture capitalBoston · Seed–Growth · 17 people tracked
Also known as .406 VENTURES MANAGEMENT, L.P.
Investment thesis
The firm focuses on early-stage technology companies with strong growth potential, concentrating on three domains where it believes it can add the most value: healthcare, data and AI, and cybersecurity. Drawing on nearly two decades of experience, it emphasizes hands-on partnership with founders, offering domain expertise, deep networks, and operational support beyond capital. Its goal is to help early-stage businesses scale into category-defining companies, positioning itself as an extension of each founder's team throughout the company-building journey.
Source: firm website, verified Aug 3, 2026.
Team · 17 people
from the firm's website
What they invest in
from 67 of 113 portfolio companiesEnterprise Software ×32Healthtech ×31AI & Machine Learning ×28Digital Health ×20SaaS ×14Data & Infrastructure ×12Cybersecurity ×10Developer Tools ×6
HQs:United States×50
Investments · 113 tracked
founders shown can be your intro path
Compass is a real estate brokerage that uses technology to help consumers find homes.
B2B MarketplacesEnterprise SoftwareMarketplacesPropTechSaaSManhattan, US
Robert Reffkin(Founder & CEO)Ori Allon(Founder & Chief Strategist)Brad Serwin(Executive Officer)Steven Sordello(Director)Allan Leinwand(Director)Josh McCarter(Director)
Heartbeat Health builds a modern cardiology ecosystem to deliver cardiovascular care through technology-enabled interventions.
Digital HealthHealthtechMedical DevicesNew York, US
Jeff Wessler(Founder & Chief Executive Officer)Brian Greer(Executive Officer)Nayan Jain(Executive Officer)Mitsu Hadeishi(Director)Sikanyiselwe Maqubela(Director)Mark Hanson(Executive Officer)
Board seatPayal Agrawal DivakaranTrip Hofer· per SEC Form D
Reltio is a cloud-native, software-as-a-service (SaaS) data platform that helps enterprises manage and unify master data to deliver business outcomes.
AI & Machine LearningData & InfrastructureEnterprise SoftwareSaaSRedwood Shores, US
Manish Sood(Founder, Chairman, and CEO)Michael Gustafson(Director)Jeffrey Schlesinger(Executive Officer)James Feuille(Director)Chetan Puttagunta(Director)
Telmai is a data observability company that monitors and enhances data reliability for enterprise customers.
AI & Machine LearningData & InfrastructureEnterprise SoftwareSaaSSan Francisco, US
Mona Rakibe(Founder)inMaxim Lukichev(Founder)inRudina Seseri(Director)Graham Brooks(Director)
Abacus Insights provides a unified data infrastructure platform that standardizes healthcare data across silos, enabling analytics and cost reduction for healthcare organizations.
Data & InfrastructureEnterprise SoftwareHealthtechBoston, US
Minalkumar Patel(Executive Officer, Director)Mike Spadafore(Director)
BoardMatthew Downs(Director)Dale White(Director)William McIvor(Director)
Board seatGraham Brooks· per SEC Form D
Boston, US
Board seatMaria CirinoGraham Brooks· per SEC Form D · $2.5M raise · filed Feb 2015
Authentication solutions making systems more automated and reliable.
Woodbridge, US
Harry Sverdlove(Director)Yaron Baitch(Executive Officer, Director)
Board seatMaria CirinoGreg Dracon· per SEC Form D
Waltham, US
Patrick Morley(Executive Officer, Director)Anthony Zingale(Director)Eric Pyenson(Executive Officer)Ronald Nordin(Director)Jeff Fagnan(Director)Paul Maeder(Director)
Board seatMaria Cirino· per SEC Form D
ChaosSearch is a data platform that indexes and analyzes large-scale data using a novel compression-optimized format designed for cloud object storage.
AI & Machine LearningCloud ComputingData & InfrastructureEnterprise Software
Board seatGraham Brooks· per SEC Form D
Cloud infrastructure cost and performance management platform.
Boston, US
Robert Davoli(Member of Board of Directors)Joe Kinsella(Chief Technology Officer and member of Board of Directors)Bob Brennan(Member of Board of Directors)Daniel Phillips(Executive Officer, Director)Dave Eicher(Chief Operating Officer, Secretary, and Treasurer)Lawrence Begley(Member of Board of Directors)
Board seatGreg Dracon· per SEC Form D
Boston, US
Philip Edmundson(Executive Officer, Director)
Board seatGraham Brooks· per SEC Form D · $120.7M raise · filed Apr 2021
Diana Health provides personalized women's healthcare through collaborative teams of OB/GYNs, midwives, mental health therapists, dietitians, and wellness coaches.
Digital HealthFemTechHealthtechWellness & Fitness
Kate Condliffe(Chief Executive Officer)Brenton Fargnoli(Director)Jeff De Flavio(Director)Payal Agrawal Divakaran(Director)Ellen Herlacker(Director)
Board seatPayal Agrawal Divakaran· per SEC Form D
CybersecurityBelmont, US
Kevin O'Brien(Executive Officer, Director)Raymond Wallace(Executive Officer, Director)
Board seatGreg Dracon· per SEC Form D
HealthtechSt. Petersburg, US
Steven G. Chrust(Director)Steve Chevalier(Director)W. Frederick Uehlein(Director)Loraine Daugherty(Executive Officer)Michael Coupland(Executive Officer, Director)
Board seatLiam Donohue· per SEC Form D · $2.8M raise · filed Mar 2026
Indico provides an intake and orchestration platform for insurance carriers that processes unstructured data such as claims, submissions, and reports to modernize how work enters and moves through insurance operations.
AI & Machine LearningEnterprise SoftwareInsurTechBoston, US
Madison May(Founder & CTO)Diana Yuan(Co-founder, SVP People & Operations)Alec Radford(Co-founder and Advisor)Slater Victoroff(Executive Officer, Director)
Board seatGraham Brooks· per SEC Form D
Boston, US
Michael Feinstein(Executive Officer, Director)Aleksandr Biberman(Executive Officer, Director)Maria Cirino(Director)Greg Dracon(Director)
Board seatMaria CirinoGreg Dracon· per SEC Form D · $2.4M raise · filed Feb 2017
Cambridge, US
NATHAN SHNIDMAN(Executive Officer, Director)BRAD GAYNOR(Executive Officer, Director, Promoter)MARIA CIRINO(Director)JEFFREY FAGNAN(Director)
Board seatMaria Cirino· per SEC Form D · $4.9M raise · filed Feb 2016
Boston, US
Board seatMaria CirinoGreg Dracon· per SEC Form D · $66.8M raise · filed Oct 2020
Onapsis provides cybersecurity solutions focused on protecting enterprise applications, particularly SAP and Oracle systems, across cloud, on-premises, and hybrid environments.
CybersecurityEnterprise SoftwareSaaSBoston, US
Mariano Nunez(Chief Executive Officer)Sadik Al-Abdulla(Chief Product Officer)Denis Cashman(Chief Financial Officer)Debi Dowling(Chief Marketing Officer | Chief of Staff)Paul Kleinschnitz(Chief Revenue Officer)Juan Pablo Perez-Etchegoyen(Chief Technology Officer)
Board seatMaria Cirino· per SEC Form D
Boston, US
Paul Paget(Executive Officer, Director)Scott Chasin(Director)Edwin Marin(Executive Officer)Maria Cirino(Director)Matt Fates(Director)Ed Pierce(Executive Officer)
Board seatMaria Cirino· per SEC Form D · $13.1M raise · filed Apr 2016
CybersecurityBoston, US
Brian Ahern(Executive Officer, Director)
Board seatMaria Cirino· per SEC Form D
Trilio provides cloud-native data protection software designed for Kubernetes, OpenStack, and KubeVirt environments.
Cloud ComputingData & InfrastructureEnterprise SoftwareHopkinton, US
Murali Balcha(Founder and CTO)Muralidhar Balcha(Executive Officer, Director)David Safaii(Executive Officer, Director)Greg Dracon(Director)Payal Agrawal Divakaran(Director)
BoardMassood Zarrabian
Board seatPayal Agrawal DivakaranGreg Dracon· per SEC Form D
HealthtechNew York, US
Liam Donohue(Director)Thomas Hawes(Director)Frank Hunt(Executive Officer)Robert Rebak(Executive Officer, Director)Russ Nash(Director)
BoardEnrico Picozza(Director)
Absurd is a platform that generates AI-produced videos for brand and performance advertising, enabling companies to produce professional-quality content within days rather than traditional timelines.
AI & Machine LearningEnterprise SoftwareMarketing TechLos Angeles, US
Philip Ho(Founder, CEO)inDamian Chng(Founder)inDaniel Kathein(Founder, CTO)in
AI-driven platform that automatically generates and contextually matches ads to online content.
Evidence-based teletherapy platform addressing alcohol use disorder.
HealthtechNew York, US
Miki Kapoor(Director)Lauren Wolfe(Executive Officer)Michael Laskoff(Executive Officer, Director, Promoter)Mark Willenbring(Executive Officer)Nina Kjellson(Director)Manish Agarwal(Director)
AristaMD is a technology-enabled clinical services provider that connects primary care physicians with board-certified specialists through eConsults to improve access to specialty care and reduce costs.
Digital HealthEnterprise SoftwareHealthtechSaaSSan Diego, US
Keith Pinter(Chief Executive Officer)Julia Jezmir(President and Chief Medical Officer)Brooke LeVasseur(Executive Officer, Director)Craig Cimini(Director)Brant Heise(Director)
BoardJohn Kuelper(Director)
Data management system for collecting and aggregating data to increase workplace productivity.
HSA optimization platform using advanced technologies for tax benefits and health spending.
HealthtechHanover, US
Adam Groff(Executive Officer, Director)Juliana Ekong(Executive Officer, Director)Myechia Minter-Jordan(Director)Yair Schindel(Director)Jon Lim(Director)Steven Kelly(Executive Officer)
Business Intelligence Advisors provides investment research and advisory services to institutional investors, helping them evaluate opportunities and manage risk across their portfolios.
FintechLegalTech
Big Health develops digital treatments and care programs for mental health conditions, including cognitive behavioral therapy-based solutions for insomnia and other mental health issues.
Digital HealthHealthtechMental Health
Peter Hames(Co-founder)Colin Espie(Co-founder)
Bluebird Kids Health provides pediatric care services with a family-centered approach.
Digital HealthHealthtechUnknown, US
AI-powered deception detection platform adapted from national security for commercial use.
Managed service provider for identity verification and strong authentication solutions.
Claren helps patients make informed medical decisions by providing evidence-based information about treatment options for chronic conditions, combining clinical guidance with AI-powered decision support tools for shared decision-making.
AI & Machine LearningDigital HealthHealthtech<UNKNOWN>
Closedloop.ai is a team-based platform for agentic software development that enables teams to define requirements, create implementation plans, and ship code collaboratively with AI agents, with full visibility and review gates before execution.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareAustin, US
Marcus Bartram(Director)David DeCaprio(Executive Officer, Director)Andrew Eye(Executive Officer, Director)Graham Brooks(Director)
BoardIan Sigalow(Director)
AI platform transforming web data and content into high-value information assets.
Medical billing advocacy platform identifying errors and appealing insurance denials.
Cortica provides in-home, in-clinic, and telehealth neurological therapies for children with autism and developmental differences, integrating neurological, biomedical, behavioral, speech-language, and sensorimotor treatments.
Digital HealthHealthtechMedical Devices<UNKNOWN>, US
Dr. Suzanne Goh(Founder)Neil Hattangadi(Executive Officer, Director)Briana Elvaiah(Executive Officer)Michael Wert(Director)
BoardRyan Drant(Director)Stephen Anastos(Director)
AI-powered platform for cyber insurance underwriting.
AI-powered software converting video into structured data for advertising and media analysis.
Disarray builds AI research agents for long-horizon autonomy over heterogeneous data, helping practitioners automate tedious ML development tasks while maintaining control over high-judgment decisions.
AI & Machine LearningData & InfrastructureDeep TechDeveloper Tools
Doris Xin(Co-founder & CEO)inMoustafa Abdelbaky(Co-founder & CTO)in
Cybersecurity platform preventing application compromise and attack progression.
Virtual care integration for OB/GYN practices providing maternal mental health care.
Youth performance psychology platform delivering evidence-based mental skills training.
Genesis Computing builds an agentic data engineering system that enables enterprises to design, reason about, and evolve data workflows faster using AI agents that understand complex data landscapes.
AI & Machine LearningData & InfrastructureEnterprise Software
Justin Langseth(Chief Technology Officer)inMatt Glickman(Chief Executive Officer)inAnton Gorshkov(Head of Engineering)in
Agentic AI data engineer fully automating data pipeline creation and maintenance.
Wilmington, US
Matthew Glickman(Executive Officer, Director)Ben Holzman(Director)Justin Langseth(Executive Officer, Director)Robert Muglia(Director)
BoardGraham Brooks(Director)
Analytics and technology platform reducing healthcare costs and improving outcomes.
Helm Health provides benefit design and member engagement tools for health plans, incorporating cost and quality data into coverage decisions, bundling claims into transparent pricing, and offering provider search functionality.
Enterprise SoftwareHealthtechInsurTechSan Francisco, US
Platform enabling carriers to launch configurable dynamic copay health plans.
HealthtechColumbus, US
Bradley Otto(Director)Kathryn Reddy(Director)Ross Klosterman(Director, Executive Officer)Olivia Cameron(Secretary of the Issuer)Brodie Stone(Mr. Stone is the Chief Revenue Officer of the Issuer.)
Humata provides an end-to-end platform to streamline prior authorization processes in healthcare, reducing delays and improving care access for patients.
AI & Machine LearningDigital HealthEnterprise SoftwareHealthtech
Jeremy Friese(Founder, MD)in
Behavioral health services rooted in cultural humility.
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Fund performance · per public LP disclosures
as of Nov 2025| Fund | Vintage | Committed | Net IRR | TVPI | DPI |
|---|---|---|---|---|---|
| POINT 406 VENTURES I, L.P.LPs: Employees' Retirement System of Rhode Island | — | — | 6.4% | 1.57x | 1.36x |
Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).
Frequently asked questions
- What stage does .406 Ventures invest at?
- .406 Ventures invests at the Seed, Series A, Series B, Series C, Growth stages.
- What is .406 Ventures's typical check size?
- .406 Ventures typically writes checks of $1M – $4M.
- What sectors does .406 Ventures focus on?
- .406 Ventures focuses on AI & Machine Learning, Cybersecurity, Data & Infrastructure, Digital Health, Healthtech, Sector Agnostic.
- Where is .406 Ventures located?
- .406 Ventures is headquartered in Boston, US.
- Does .406 Ventures lead rounds?
- Yes, .406 Ventures leads investment rounds.
Media · Podcasts & interviews
featuring the teamGraham Brooks, Partner at .406 Ventures - The VentureFizz Podcast
VentureFizz · Graham Brooks
The HLTH Daily Show Ft. Payal Agrawal Divakaran, .406 Ventures, Partner
Chitra Nawbatt · Payal Agrawal Divakaran
Payal Agrawal Divakaran, Partner at .406 Ventures - Top Healthcare Investor
Top Startup Series · Payal Agrawal Divakaran
Maria Cirino - Managing Partner at .406 Ventures (Full Interview)
TAG Infosphere · Maria Cirino
.406 Ventures' Maria Cirino for Boston UpFront
BostInno · Maria Cirino
Images
Co-investors · 53
F-Prime Capital Partners is a venture capital firm whose team of scientists, engineers, physicians, operators, and investors supports companies in scaling and accelerating growth.
Flare Capital Partners is a venture capital firm specializing in healthcare technology, backing founders building software, data, and AI infrastructure for the healthcare industry.
RRE Ventures is a boutique early-stage venture capital firm that backs founders across sectors, combining decades of experience with AI-driven analysis throughout the investment lifecycle.
Accomplice is a venture capital firm that has backed early-stage companies across sectors, having been part of the origin stories of companies like AngelList, DraftKings, Patreon and WHOOP.
Echo Health Ventures is a strategic venture capital and growth equity investor that partners with health care companies to help build and scale their innovations nationally.
General Catalyst is a venture capital and investment firm that backs founders across industries, with a strong focus on AI-driven transformation, fintech, healthcare, and other sectors.
Glasswing Ventures is an early-stage venture capital firm that supports startups through its Building Partners model, providing operational expertise across go-to-market, product, engineering, and finance.
Uncork Capital is a seed-stage venture firm that backs founders at the earliest stage, before their potential is widely recognized.
Sapphire Ventures is a venture capital firm founded in 2011 that backs technology companies, offering operating support such as executive talent and customer introductions to its portfolio.
Scale Venture Partners is an early-stage investor that partners with AI companies to help them grow from founder-led growth into a scalable go-to-market operation.
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
Zetta Venture Partners provides early-stage capital and hands-on support to founders building AI-native applications, infrastructure, and developer tools.
▶41 more co-investors
Evolution Equity PartnersSequoia CapitalFirst Round CapitalFlybridge Capital PartnersCrosslink CapitalNexus Venture PartnersHighland Capital PartnersOpenView Venture PartnersFounders Circle CapitalAscension VenturesSandbox IndustriesaMoonLytical VenturesBenchmarkB Capital GroupKapor CapitalObvious VenturesMeritech Capital PartnersPractical Venture CapitalDCM VenturesBallistic VenturesEnergy Impact PartnersAnorak VenturesCisco InvestmentsVitalStage VenturesEndeavor CatalystPhoenix CourtVertex Ventures Southeast Asia & IndiaNational Grid PartnersGutbrain VenturesAllegisCyber CapitalCambridge Innovation CapitalEight Roads VenturesTop Tier Capital PartnersGeneration Investment ManagementMonk's Hill VenturesNew Markets Venture PartnersSeae VenturesInnova Memphis, Inc.BlueCross BlueShield Venture PartnersOmidyar Technology Ventures
Firms observed investing alongside .406 Ventures, from public investor directories. Shared companies are the overlap with .406 Ventures's recorded portfolio.
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