.406 Ventures
Boston · Seed–Series B · 17 people tracked
Investment thesis
406 Ventures partners intensively with founders from investment through exit, operating as hands-on collaborators rather than passive capital providers. The firm adopts a selective investment philosophy inspired by Ted Williams' hitting approach—focusing on opportunities where the firm has distinctive capabilities and competitive advantage rather than pursuing all available opportunities. Success is measured by long-term value creation, demonstrated by $23B+ in portfolio value, and the conviction of returning entrepreneurs, with over 20% of investments coming from repeat founders.
Source: firm website, verified Jul 20, 2026.
Team · 17 people
from the firm's websiteCo-founder of 406 Ventures who established the firm in 2005 with a commitment to hands-on partnership and supporting entrepreneurs through all stages of company building.
Co-founder of 406 Ventures who established the firm in 2005 with a commitment to hands-on partnership and supporting entrepreneurs through all stages of company building.
Co-founder of 406 Ventures who established the firm in 2005 with a commitment to hands-on partnership and supporting entrepreneurs through all stages of company building.
What they invest in
from 52 of 124 portfolio companiesEnterprise Software ×31AI & Machine Learning ×25Healthtech ×24Digital Health ×19Data & Infrastructure ×12SaaS ×11Cybersecurity ×6Cloud Computing ×5
HQs:United States×18
Investments · showing 60 of 124
founders shown can be your intro pathReltio is a cloud-native, software-as-a-service (SaaS) data platform that helps enterprises manage and unify master data to deliver business outcomes. It serves Global 2000 companies seeking to accelerate data value and power data-driven decision-making through real-time, trusted data and AI integration.
AI & Machine LearningData & InfrastructureEnterprise SoftwareSaaS
Manish Sood(Founder, Chairman, and CEO)
Telmai is a data observability company that monitors and enhances data reliability for enterprise customers. The platform helps organizations ensure the quality and integrity of their data infrastructure.
AI & Machine LearningData & InfrastructureEnterprise SoftwareSaaSSan Francisco, US
Heartbeat Health builds a modern cardiology ecosystem to deliver cardiovascular care through technology-enabled interventions. The company serves healthcare providers and patients seeking advanced cardiac care solutions.
Digital HealthHealthtechMedical Devices
Jeff Wessler(Founder & Chief Executive Officer)
Centralized data, insights, and AI platform for the healthcare ecosystem.
Abacus Insights provides a unified data infrastructure platform that standardizes healthcare data across silos, enabling analytics and cost reduction for healthcare organizations.
Data & InfrastructureEnterprise SoftwareHealthtech
Evidence-based virtual mental health intervention platform. Acquired by Optum.
AI-powered creative production platform using autonomous agents to generate marketing videos and ads.
Absurd is a platform that generates AI-produced videos for brand and performance advertising, enabling companies to produce professional-quality content within days rather than traditional timelines.
AI & Machine LearningEnterprise SoftwareMarketing TechLos Angeles, US
Philip Ho(Founder, CEO)inDamian Chng(Founder)inDaniel Kathein(Founder, CTO)in
AI-driven platform that automatically generates and contextually matches ads to online content. Acquired by Etsy.
Evidence-based teletherapy platform addressing alcohol use disorder.
Arboretum provides genetic testing programs and patient registry infrastructure for healthcare systems to implement precision medicine for cardiovascular disease, cancer, and metabolic conditions. The company enables clinical integration and translational research to accelerate precision medicine trials.
BiotechDigital HealthMedical Devices
AristaMD is a technology-enabled clinical services provider that connects primary care physicians with board-certified specialists through eConsults to improve access to specialty care and reduce costs. The platform serves healthcare systems and primary care providers seeking to manage patient risk and improve care delivery outcomes.
Digital HealthEnterprise SoftwareHealthtechSaaS
Keith Pinter(Chief Executive Officer)Julia Jezmir(President and Chief Medical Officer)
Ascellus Behavioral Health provides evidence-based behavioral health services and psychological evaluations for workers' compensation claims, addressing psychosocial factors that interfere with recovery following physical injury. The company serves claims adjusters and nurse case managers in the workers' compensation industry.
Digital HealthHealthtechInsurTechMental Health
Authentication solutions making systems more automated and reliable. Acquired by LogMeIn.
Data management system for collecting and aggregating data to increase workplace productivity. Acquired by Formstack.
HSA optimization platform using advanced technologies for tax benefits and health spending. Acquired by Webster Financial.
Tech-enabled medically assisted treatment programs for substance use disorder.
Business Intelligence Advisors provides investment research and advisory services to institutional investors, helping them evaluate opportunities and manage risk across their portfolios.
FintechLegalTech
FDA-approved digital treatments for sleep and mental health conditions.
Value-based pediatric platform providing accessible care for Medicaid-insured children.
Bluebird Kids Health provides pediatric care services with a family-centered approach. The company aims to transform healthcare delivery for children and their families.
Digital HealthHealthtechUnknown, US
Data-sharing platform enabling users to make data available across cloud and data platforms.
Bobsled provides a data collaboration platform that enables businesses to work together on data across cloud environments. The company serves enterprises and data teams seeking improved data access and collaboration capabilities.
AI & Machine LearningCloud ComputingData & InfrastructureEnterprise Software
AI-powered deception detection platform adapted from national security for commercial use.
Advanced threat protection for servers and endpoints. Acquired by VMware.
ChaosSearch is a data platform that indexes and analyzes large-scale data using a novel compression-optimized format designed for cloud object storage. It serves organizations looking to perform cost-efficient analytics on data lakes without traditional sharding or block storage requirements.
AI & Machine LearningCloud ComputingData & InfrastructureEnterprise Software
Managed service provider for identity verification and strong authentication solutions. Acquired by PGP.
Shared decision-making platform helping health plans reduce low-value utilization.
Claren helps patients make informed medical decisions by providing evidence-based information about treatment options for chronic conditions, combining clinical guidance with AI-powered decision support tools for shared decision-making.
AI & Machine LearningDigital HealthHealthtech<UNKNOWN>
Closedloop.ai is a team-based platform for agentic software development that enables teams to define requirements, create implementation plans, and ship code collaboratively with AI agents, with full visibility and review gates before execution.
AI & Machine LearningDeveloper ToolsEnterprise Software
End-to-end healthcare data science and AI platform improving clinical and financial outcomes.
Cloud infrastructure cost and performance management platform. Acquired by VMware.
AI-powered real estate platform making search and sell experience intelligent. IPO.
AI platform transforming web data and content into high-value information assets. Acquired by Import.io.
Medical billing advocacy platform identifying errors and appealing insurance denials. Acquired by Mebex.
Cortica provides in-home, in-clinic, and telehealth neurological therapies for children with autism and developmental differences, integrating neurological, biomedical, behavioral, speech-language, and sensorimotor treatments. The company serves families and children seeking developmental and learning acceleration.
Digital HealthHealthtechMedical Devices<UNKNOWN>
Dr. Suzanne Goh(Founder)
Value-based platform integrating medical and behavioral care for autism spectrum disorder treatment.
AI-powered platform for cyber insurance underwriting. Acquired by Travelers.
Diana is a platform for managing flexible work and HR operations. The company serves businesses and employees seeking more flexible, inclusive work arrangements.
AI & Machine LearningConsumerDigital HealthEnterprise SoftwareFuture of WorkHR TechSaaSSan Francisco, US
Upeka(Co-founder & CEO)Dilan(Co-founder)GautamJohn Wang(Chief of Staff)
Network of modern women's health practices providing maternity and gynecological care.
AI-powered software converting video into structured data for advertising and media analysis. Acquired by TiVO.
Disarray builds AI research agents for long-horizon autonomy over heterogeneous data, helping practitioners automate tedious ML development tasks while maintaining control over high-judgment decisions. The company combines deep systems research with production ML expertise to create autonomous agents that track context, reuse prior work, and sustain open-ended experimental loops.
AI & Machine LearningData & InfrastructureDeep TechDeveloper Tools
Doris Xin(Co-founder & CEO)Moustafa Abdelbaky(Co-founder & CTO)
Cybersecurity platform preventing application compromise and attack progression. Acquired by Zscaler.
Equip provides virtual care and treatment services for eating disorders through a digital platform. The company serves patients and families seeking evidence-based eating disorder treatment.
Digital HealthHealthtechMental Health
Kristina Saffran(CEO & Co-Founder)Erin Parks(Chief Clinical Officer & Co-Founder)
Virtual care integration for OB/GYN practices providing maternal mental health care.
Youth performance psychology platform delivering evidence-based mental skills training.
Genesis Computing builds an agentic data engineering system that enables enterprises to design, reason about, and evolve data workflows faster using AI agents that understand complex data landscapes. The platform serves enterprises and digital-first companies with complex data pipelines, operating alongside existing data platforms like Snowflake, AWS, and Databricks.
AI & Machine LearningData & InfrastructureEnterprise Software
Matt Glickman(Chief Executive Officer)inJustin Langseth(Chief Technology Officer)inAnton Gorshkov(Head of Engineering)in
Agentic AI data engineer fully automating data pipeline creation and maintenance.
Comprehensive cloud email security platform combining threat detection and remediation.
Analytics and technology platform reducing healthcare costs and improving outcomes. Acquired by Bupa.
National virtual cardiovascular care provider.
Helm Health provides benefit design and member engagement tools for health plans, incorporating cost and quality data into coverage decisions, bundling claims into transparent pricing, and offering provider search functionality.
Enterprise SoftwareHealthtechInsurTechSan Francisco, US
Platform enabling carriers to launch configurable dynamic copay health plans.
AI-driven prior authorization automation for health systems and payers.
Humata provides an end-to-end platform to streamline prior authorization processes in healthcare, reducing delays and improving care access for patients. The company serves healthcare providers and payers seeking to simplify insurance approval workflows.
AI & Machine LearningDigital HealthEnterprise SoftwareHealthtech
Jeremy Friese(Founder, MD)
Behavioral health services rooted in cultural humility. Acquired by Backpack Healthcare.
HYPR provides phishing-resistant, passwordless authentication for enterprise security teams using device-bound passkeys and public key cryptography. The platform integrates with existing identity providers and security tools to support Zero Trust initiatives and compliance requirements including PCI DSS and NIST standards.
CybersecurityEnterprise SoftwareSaaS
Business intelligence and automation platform for insurance and financial services powered by LLMs.
Indico provides an intake and orchestration platform for insurance carriers that processes unstructured data such as claims, submissions, and reports to modernize how work enters and moves through insurance operations. The platform automates manual intake processes, enriches and validates work before routing to downstream systems, and enables insurers to expand capacity and reduce operational delays.
AI & Machine LearningEnterprise SoftwareInsurTech
Madison May(Founder & CTO)Diana Yuan(Co-founder, SVP People & Operations)Alec Radford(Co-founder and Advisor)
Board seats · per SEC filings
what is this? ⓘ$25M raise · filed Jul 2024 · via Trip Hofer
Inferred from directors named on each company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does .406 Ventures invest at?
- .406 Ventures invests at the Seed, Series A, Series B stages.
- What sectors does .406 Ventures focus on?
- .406 Ventures focuses on AI & Machine Learning, Cybersecurity, Data & Infrastructure, Healthtech, Sector Agnostic.
- Where is .406 Ventures located?
- .406 Ventures is headquartered in Boston, US.
Media · Podcasts & interviews
featuring the teamMaria Cirino - Managing Partner at .406 Ventures (Full Interview) - YouTube
TAG Infosphere · Maria Cirino
.406 Ventures' Maria Cirino for Boston UpFront - YouTube
BostInno · Maria Cirino
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