Boston · Seed–Growth · 19 people tracked
Also known as .406 VENTURES MANAGEMENT, L.P.
Find your way into .406 Ventures
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Investment thesis
The firm focuses on early-stage technology companies with strong growth potential, concentrating on three domains where it believes it can add the most value: healthcare, data and AI, and cybersecurity. Drawing on nearly two decades of experience, it emphasizes hands-on partnership with founders, offering domain expertise, deep networks, and operational support beyond capital. Its goal is to help early-stage businesses scale into category-defining companies, positioning itself as an extension of each founder's team throughout the company-building journey.
Source: firm website, verified Sep 15, 2026.
Team · 19 people
from the firm's website & curated
Founder mafia
5 people who came through .406 Ventures went on to found or lead other companies.
What they invest in
from 82 of 125 portfolio companiesEnterprise Software ×39Healthtech ×35AI & Machine Learning ×32Digital Health ×25SaaS ×22Data & Infrastructure ×15Cybersecurity ×14Fintech ×9
HQs:United States×77United Kingdom×1
Who they back
founder profiles across 51 portfolio companiesFounding team size:solo founder×232 founders×183 founders×74+ founders×3
Where their founders studiedfrom 57 founders with education data
Franklin W. Olin College of Engineering ×4Harvard Business School ×4Harvard University ×4Cornell ×3Northwestern University ×3Boston University ×2Columbia Business School ×2Harvard Kennedy School ×2
What their founders studiedfrom 49 founders with field-of-study data
Computer Science ×21Economics ×7Business & Management ×6Engineering ×4Finance & Accounting ×4Medicine ×4Social Sciences ×4Humanities ×2
Where their founders worked beforefrom 56 founders with career history
McKinsey & Company ×5Harvard Medical School ×3Brigham and Women's Hospital ×2Cisco ×2Flare Capital Partners ×2Goldman Sachs ×2Massachusetts Institute of Technology (MIT) ×2McLean Hospital ×2
Accelerator rootsportfolio companies that came through a program
9 founders hold a PhD · 16 hold an MBA (of 57 with degree data)
Investments · 125 tracked
founders shown can be your intro pathBy year:2026 · 62025 · 22024 · 82023 · 72022 · 82021 · 52020 · 62019 · 12018 · 22017 · 42016 · 62015 · 771 dated
Compass is a real estate brokerage that uses technology to help consumers find homes.
B2B MarketplacesEnterprise SoftwareMarketplacesPropTechSaaSManhattan, US
Robert Reffkin(Founder & CEO)inOri Allon(Founder & Chief Strategist)Brad Serwin(Executive Officer)Kalani Reelitz(Executive Officer)Ethan Glass(Executive Officer)inScott Wahlers(Executive Officer)
Co-investorsAdvance Venture PartnersAlpaca VCCorigin VenturesEntropy Industrial CapitalGlynn Capital ManagementIVP (Institutional Venture Partners)+5 more
Kaltura provides AI-powered video platforms for live and on-demand digital experiences that enable brands and organizations to engage audiences and achieve business goals.
AI & Machine LearningEnterprise SoftwareMedia & EntertainmentNew York, US
Ron Yekutiel(Founder)inShay David(Director)inEynav Azaria(Chief Product, Engineering and Marketing Officer)inNatan Israeli(Chief Customer and Commercial Officer)in
Co-investorsAvalon Ventures Management, LlcLuminari CapitalMitsui Global InvestmentNGP CapitalRuna CapitalSapphire Ventures+4 more
Heartbeat Health builds a modern cardiology ecosystem to deliver cardiovascular care through technology-enabled interventions.
Digital HealthHealthtechMedical DevicesNew York, US
Jeffrey Wessler(Founder)inBrian Greer(Executive Officer)Mark Hanson(Executive Officer)Nayan Jain(Executive Officer)
BoardSteve Dildine(Director)
Board seatPayal DivakaranTrip Hofer· per SEC Form D
Co-investorsEcho Health VenturesDesigner FundHitachi VenturesKindred VenturesLerer HippeauOptum Ventures+1 more
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Reltio is a cloud-native, software-as-a-service (SaaS) data platform that helps enterprises manage and unify master data to deliver business outcomes.
AI & Machine LearningData & InfrastructureEnterprise SoftwareSaaSRedwood Shores, US
Manish Sood(Founder, Chairman, and CEO)inJeffrey Schlesinger(Executive Officer)in
BoardJames Feuille(Director)inChetan Puttagunta(Director)Michael Gustafson(Director)
Co-investorsCrosslink CapitalNewView CapitalSapphire VenturesBrighton Park CapitalNew Enterprise Associates (NEA)RPS Ventures+3 more
Telmai is a data observability company that monitors and enhances data reliability for enterprise customers.
AI & Machine LearningData & InfrastructureEnterprise SoftwareSaaSSan Francisco, US
Mona Rakibe(Founder)inMaxim Lukichev(Founder)in
BoardRudina Seseri(Director)inGraham Brooks(Director)in
Co-investorsGlasswing VenturesY CombinatorZetta Venture Partners
Abacus Insights provides a unified data infrastructure platform that standardizes healthcare data across silos, enabling analytics and cost reduction for healthcare organizations.
Data & InfrastructureEnterprise SoftwareHealthtechBoston, US
Minalkumar Patel(Executive Officer, Director)in
BoardMatthew Downs(Director)Mike Spadafore(Director)inDale White(Director)William McIvor(Director)
Board seatGraham Brooks· per SEC Form D
Co-investorsEcho Health VenturesEscalate Capital PartnersCRV (Charles River Ventures)
Waltham, US
Patrick Morley(Executive Officer, Director)inEric Pyenson(Executive Officer)Gordon Pothier(Executive Officer)
BoardRonald Nordin(Director)Jeff Fagnan(Director)Paul Maeder(Director)in
Board seatMaria Cirino· per SEC Form D
Co-investorsAccompliceEvolution Equity PartnersFounders Circle CapitalIntel CapitalKleiner PerkinsRally Ventures Management, Llc+4 more
ChaosSearch is a data platform that indexes and analyzes large-scale data using a novel compression-optimized format designed for cloud object storage.
AI & Machine LearningCloud ComputingData & InfrastructureEnterprise SoftwareBoston, US
Thomas Hazel(Director)inEd Walsh(Executive Officer, Director)in
BoardLes Yetton(Director)inRudina Seseri(Director)inDavid Baum(Director)in
Board seatGraham Brooks· per SEC Form D
Co-investorsStage 1 VenturesStripesGlasswing Ventures
Corvus Insurance provides cyber and Tech E&O insurance paired with threat intelligence, cyber advisory services, and dedicated claims support, distributed through commercial insurance brokers in the United States.
CybersecurityFintechInsurTechHartford, US
Philip Edmundson(Executive Officer, Director)in
Board seatGraham Brooks· per SEC Form D · $120.7M raise · filed Apr 2021
Co-investorsInsight PartnersMTECH CAPITALObvious VenturesTitanium VenturesAquiline Technology Growth
Diana Health provides personalized women's healthcare through collaborative teams of OB/GYNs, midwives, mental health therapists, dietitians, and wellness coaches.
Digital HealthFemTechHealthtechWellness & FitnessNew York, US
Kate Condliffe(Chief Executive Officer)in
BoardBrenton Fargnoli(Director)inJeff De Flavio(Director)Payal Agrawal Divakaran(Director)inEllen Herlacker(Director)
Board seatPayal Divakaran· per SEC Form D
Co-investorsAlleyCorpNorwest Venture PartnersAlley Robotics VenturesLRVHealth
GreatHorn was a cloud-native email security platform for phishing and account-takeover defense, acquired by Proofpoint in 2022.
CybersecurityBelmont, US
Kevin O'Brien(Executive Officer, Director)Raymond Wallace(Executive Officer, Director)in
Board seatGreg Dracon· per SEC Form D
Co-investorsFf Venture CapitalTechstarsUncork CapitalZelkova Ventures2048 VenturesRRE Ventures
Indico provides an intake and orchestration platform for insurance carriers that processes unstructured data such as claims, submissions, and reports to modernize how work enters and moves through insurance operations.
AI & Machine LearningEnterprise SoftwareInsurTechSaaSBoston, US
Madison May(Founder & CTO)inDiana Yuan(Co-founder, SVP People & Operations)inAlec Radford(Co-founder and Advisor)inSlater Victoroff(Executive Officer, Director)in
Board seatGraham Brooks· per SEC Form D
Co-investorsBoston Seed CapitalHyperplane Venture CapitalOsage Venture PartnersTechstarsAviva VenturesSandbox Industries
MineralTree offers accounts payable automation for finance teams, covering invoice capture, approval routing, payment authorization, and payment optimization.
Enterprise SoftwareFintechSaaSBoston, US
BC Krishna(Executive Officer, Director)inMicah RemleyinBill Price(Executive Officer)in
BoardRaj Dugar(Director)
Board seatMaria CirinoGreg Dracon· per SEC Form D
Co-investorsF-Prime CapitalEight Roads VenturesGreat Hill Partners
Onapsis provides cybersecurity solutions focused on protecting enterprise applications, particularly SAP and Oracle systems, across cloud, on-premises, and hybrid environments.
CybersecurityEnterprise SoftwareSaaSBoston, US
Mariano Nunez(Chief Executive Officer)inSadik Al-Abdulla(Chief Product Officer)inDenis Cashman(Chief Financial Officer)inDebi Dowling(Chief Marketing Officer | Chief of Staff)inPaul Kleinschnitz(Chief Revenue Officer)inJuan Pablo Perez-Etchegoyen(Chief Technology Officer)
Board seatMaria Cirino· per SEC Form D
Co-investorsEvolution Equity PartnersGolub GrowthNightDragonLa Caisse
CybersecurityBoston, US
Jennifer M. Andre(Executive Officer)Dustin Webber(Director)Brian Ahern(Executive Officer, Director)inDoug Cahill(Executive Officer, Director)in
BoardChristopher P. Lynch(Director)
Board seatMaria Cirino· per SEC Form D
Co-investorsF-Prime Capitalfama Ventures, LLCTechstarsAccompliceEight Roads VenturesScale Venture Partners
Trilio provides cloud-native data protection software designed for Kubernetes, OpenStack, and KubeVirt environments.
Cloud ComputingData & InfrastructureEnterprise SoftwareHopkinton, US
Murali Balcha(Founder and CTO)inDavid Safaii(Executive Officer, Director)in
BoardPayal Agrawal Divakaran(Director)inMassood Zarrabian
Board seatPayal DivakaranGreg Dracon· per SEC Form D
Co-investorsCerity Partners VenturesWindspeed VenturesHyperplane Venture Capital
AbleTo provides in-person and virtual mental health care, including therapy, psychiatry, and medication management for adults, children, and teens dealing with concerns such as anxiety, depression, ADHD, and substance use.
Digital HealthHealthtechMental HealthNew York, US
Michael Laskoff(Executive Officer, Director)Trip HoferinPaul Pieper(Executive Officer)Tom Brennan(Executive Officer)Frank Hunt(Executive Officer)Robert Rebak(Executive Officer, Director)
Co-investorsBlue Venture FundsHLM Venture PartnersOptum VenturesValspring CapitalBain Capital VenturesHorizon+1 more
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Absurd is a platform that generates AI-produced videos for brand and performance advertising, enabling companies to produce professional-quality content within days rather than traditional timelines.
AI & Machine LearningEnterprise SoftwareMarketing TechLos Angeles, US
Philip Ho(Founder, CEO)inDamian Chng(Founder)inDaniel Kathein(Founder, CTO)in
Co-investorsAudaciousY Combinator
AristaMD is a technology-enabled clinical services provider that connects primary care physicians with board-certified specialists through eConsults to improve access to specialty care and reduce costs.
Digital HealthEnterprise SoftwareHealthtechSaaSSan Diego, US
Keith Pinter(Chief Executive Officer)inJulia Jezmir(President and Chief Medical Officer)inBrooke LeVasseur(Executive Officer, Director)inDouglas Downs(Executive Officer, Director)Rebecca Cofinas(Executive Officer, Director)
BoardJohn Kuelper(Director)in
Co-investorsAscension VenturesCobalt VenturesMemorialCare Innovation FundOptum VenturesAvalon BioVenturesAvalon Ventures Management, Llc
Ascellus Behavioral Health provides evidence-based behavioral health services and psychological evaluations for workers' compensation claims, addressing psychosocial factors that interfere with recovery following physical injury.
Digital HealthHealthtechInsurTechMental Health
Co-investorsHLM Venture Partners
Better Life Partners provides same-day medication-assisted treatment for opioid and alcohol addiction, combining counseling, community support, and medication for people in recovery.
Digital HealthHealthtechMental HealthHanover, US
Adam Groff(Executive Officer, Director)inJuliana Ekong(Executive Officer, Director)Myechia Minter-Jordan(Director)Steven Kelly(Executive Officer)
BoardYair Schindel(Director)inJon Lim(Director)in
Co-investorsaMoonF-Prime CapitalMaverick Ventures
Business Intelligence Advisors provides investment research and advisory services to institutional investors, helping them evaluate opportunities and manage risk across their portfolios.
FintechLegalTech
Big Health develops digital treatments and care programs for mental health conditions, including cognitive behavioral therapy-based solutions for insomnia and other mental health issues.
Digital HealthHealthtechMental Health
Peter Hames(Co-founder)inColin Espie(Co-founder)
Co-investorsAlleyCorpIndex VenturesInnovation Global CapitalKaiser Permanente VenturesMolten VenturesNextGen Venture Partners+6 more
Bluebird Kids Health provides pediatric care services with a family-centered approach.
Digital HealthHealthtech
Chris Johnson(Founder, Chief Executive Officer)inRachel Wilson(Co-Founder, Chief Operating Officer)inDr. Michael Glazier, MD(Co-Founder, Chief Medical Officer)Elizabeth Larsen(Co-Founder, Chief of Staff)in
Co-investorsAIFF-Prime CapitalJUXTAPOSE VENTURES
Bobsled provides a data collaboration platform that enables businesses to work together on data across cloud environments.
AI & Machine LearningCloud ComputingData & InfrastructureEnterprise SoftwareLos Angeles, US
Jake Graham(Founder)in
Co-investorsAviso VenturesGreycroftMadrona Venture GroupK5 Global
Claren helps patients make informed medical decisions by providing evidence-based information about treatment options for chronic conditions, combining clinical guidance with AI-powered decision support tools for shared decision-making.
AI & Machine LearningDigital HealthHealthtech
Closedloop.ai is a team-based platform for agentic software development that enables teams to define requirements, create implementation plans, and ship code collaboratively with AI agents, with full visibility and review gates before execution.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareAustin, US
David DeCaprio(Executive Officer, Director)Andrew Eye(Executive Officer, Director)in
BoardMarcus Bartram(Director)inIan Sigalow(Director)inGraham Brooks(Director)in
Co-investorsBreyer CapitalCentral Texas Angel NetworkGreycroftJoyance PartnersMeridian Street CapitalOssian Capital+1 more
Cortica provides in-home, in-clinic, and telehealth neurological therapies for children with autism and developmental differences, integrating neurological, biomedical, behavioral, speech-language, and sensorimotor treatments.
Digital HealthHealthtechMedical DevicesSan Diego, US
Dr. Suzanne Goh(Founder)Neil Hattangadi(Executive Officer, Director)inBriana Elvaiah(Executive Officer)in
BoardRyan Drant(Director)inStephen Anastos(Director)Justin Brock(Director)in
Co-investorsAIFAPERTURE Venture PartnersCVS Health VenturesEcho Health VenturesLongitude CapitalOptum Ventures+5 more
Elmsford, US
Jonathan Taqqu(Executive Officer, Director)
BoardJohn Lee(Director)
Co-investorsHealthy VenturesAlleyCorpCVS Health VenturesGilde HealthcareSandbox Clinical Ventures
Diana is a platform for managing flexible work and HR operations.
AI & Machine LearningConsumerDigital HealthEnterprise SoftwareFuture of WorkHR TechSaaSSan Francisco, US
Upeka Bee(Founder)inDilan(Co-founder)inGautamin
Co-investorsY CombinatorAlleyCorpGeneral CatalystHealthQuest CapitalLRVHealthNorwest Venture Partners+1 more
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Disarray builds AI research agents for long-horizon autonomy over heterogeneous data, helping practitioners automate tedious ML development tasks while maintaining control over high-judgment decisions.
AI & Machine LearningData & InfrastructureDeep TechDeveloper ToolsSan Francisco, US
Doris Xin(Co-founder & CEO)inMoustafa Abdelbaky(Co-founder & CTO)in
Equip provides virtual care and treatment services for eating disorders through a digital platform.
Digital HealthHealthtechMental Health
Kristina Saffran(Co-founder)inErin Parks(Co-founder, clinical psychologist)in
Co-investorsCoalition OperatorsF-Prime CapitalOptum VenturesPLUS CapitalThe Chernin Group (TCG Crypto)
Youth performance psychology platform delivering evidence-based mental skills training.
Genesis Computing builds an agentic data engineering system ("Genesis Data Agents") of AI workers that run inside customer-managed environments alongside platforms such as Snowflake, AWS, and Databricks to accelerate the enterprise data lifecycle and preserve institutional knowledge.
AI & Machine LearningData & InfrastructureEnterprise SoftwareWilmington, US
Justin Langseth(Co-founder & CTO)inMatt Glickman(Co-founder & CEO)inAnton Gorshkov(Head of Engineering)inVince Trotta(Head of Sales)Margarita Barrera(Chief Operating Officer)in
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BoardBen Holzman(Director)
Co-investorsNextGen Venture PartnersKearny Jackson
Heartbeat is an all-in-one platform for community builders to run memberships, courses, events, and payments on their own branded website, with channels, live rooms, DMs, and a member directory.
Creator EconomyEdTechSaaSSocialAndover, US
James McQuade(Executive Officer, Director)
Co-investorsJoyance PartnersService Provider CapitalSocial StartsCressey & CompanyOptum Ventures
Helm Health provides benefit design and member engagement tools for health plans, incorporating cost and quality data into coverage decisions, bundling claims into transparent pricing, and offering provider search functionality.
Enterprise SoftwareHealthtechInsurTechSan Francisco, US
Co-investors3CC | Third Culture CapitalFlare Capital PartnersHeadwater VenturesSemperVirens Venture CapitalDigitalis VenturesInitialized Capital
Humata provides an end-to-end platform to streamline prior authorization processes in healthcare, reducing delays and improving care access for patients.
AI & Machine LearningDigital HealthEnterprise SoftwareHealthtechMiami, US
Jeremy Friese(Founder, MD)inOscar Callejas(Executive Officer)inMichael Kolb(Executive Officer)inPhilip Fibiger(Executive Officer)in
BoardWord D. Peake(Director)Thomas Hawes(Director)in
Co-investorsBlue Venture FundsLRVHealthOptum VenturesOSF Ventures
HYPR provides phishing-resistant, passwordless authentication for enterprise security teams using device-bound passkeys and public key cryptography.
CybersecurityEnterprise SoftwareSaaSNew York, US
Roman Kadinsky(Founder)in
Co-investorsComcast VenturesRTP GlobalAdvent InternationalRRE Ventures
InStride provides virtual specialty care for young people ages 7 to 24 with anxiety, OCD, and related disorders, using evidence-based treatment enhanced by AI technology.
Digital HealthHealthtechMental Health
Mona Potter(Clinical Co-founder, MD)inKathryn Boger(Clinical Co-founder, Ph.D., ABPP)inJohn Voith(Founder)in
Co-investorsEcho Health VenturesGeneral Catalyst
Iora Health was a primary care company focused on value-based care for Medicare-eligible seniors, operating clinics with a team-based model including health coaches.
Digital HealthHealthtechWellness & FitnessSan Francisco, US
RUSHIKA FERNANDOPULLE(Executive Officer, Director)inCHRISTOPHER J. MCKOWN(Executive Officer, Director)DAVID FIELDING(Executive Officer)ALEXANDER PACKARD(Executive Officer)inDAVID JUDGE(Executive Officer)
BoardSTEPHEN KNIGHT(Director)in
Co-investorsDag VenturesF-Prime CapitalFlare Capital PartnersGV (Google Ventures)Lifeforce CapitalMaverick Ventures+5 more
DreamFold builds a protein therapeutics platform that uses AI-driven protein design, generative modelling, and high-throughput screening to develop new classes of protein drugs for diseases lacking effective treatments.
AI & Machine LearningBiotechDeep TechNew MaterialsSemiconductorsCambridge, GB
Kerry Baldwin(Founder)inColin Humphreys(Co-founder)Simon Thomas(Co-founder & CEO)
Co-investorsEnterprise Capital FundsGEIF VenturesKPN VenturesRaisonAlbum VCBayern Kapital+7 more
Keebo optimizes cloud data workloads on Snowflake and Databricks using AI algorithms to reduce costs while maintaining service level agreements, serving data teams and organizations managing large-scale data infrastructure.
AI & Machine LearningCloud ComputingData & Infrastructure
Barzan Mozafari(Co-Founder)in
Co-investorsNeotribe VenturesTrue Ventures
Laudio builds a SaaS platform that supports frontline leaders in hospitals and health systems, using data and analytics to improve employee engagement, retention, and operational outcomes.
AI & Machine LearningDigital HealthHR TechSaaSNewton, US
Russell Richmond, MD(Executive Officer, Director)Tim Darling(Co-founder & President, Laudio Insights)inKevin Kumler(Director)Constantine John Floros(Executive Officer, Director)Lisa Mastrangelo(Executive Officer)Mike Caffrey(Director)
Co-investorsInHealth VenturesDefine VenturesMemorialCare Innovation Fund
Disarray is an AI research company focused on autonomous agents for long-running tasks and automating model development through agentic search and context graphs.
AI & Machine LearningData & InfrastructureDeep TechDeveloper ToolsEnterprise Software
Doris Xin(Co-founder & CEO)Moustafa Abdelbaky(Co-founder & CTO)
Co-investorsEssence Venture CapitalLaude Ventures
Lynx provides payment and financial services infrastructure that connects health and finance for consumers, enabling them to afford and pay for healthcare.
FintechHealthtechSaaS
Isoken Abel(Founder)in
Co-investorsCVS Health VenturesFlare Capital PartnersFrist Cressey VenturesMcKesson VenturesObvious Ventures
Latica provides a secure platform for accessing and analyzing real-world structured and unstructured patient data across the patient journey, including images, physician notes, and video.
AI & Machine LearningData & InfrastructureHealthtech
Ofir Farchy(Founder)in
Co-investorsMizMaa VenturesCVS Health VenturesFlare Capital PartnersFrist Cressey VenturesMcKesson VenturesObvious Ventures
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Co-investorsCisco InvestmentsOpenView Venture PartnersUncork Capital
Mindgard provides AI security solutions that help enterprises identify, assess, and mitigate threats across AI models, agents, and applications throughout the AI lifecycle.
AI & Machine LearningCybersecurityEnterprise SoftwareBoston, US
Dr. Peter GarraghaninJames Brear(CEO)inAaron Portnoy(Head of Research)inRich Smith(Offensive Security Lead)in
Co-investorsAtlantic Bridge VenturesIQ CapitalOsney CapitalAlbum VCKarma VenturesLakestar
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Nace provides AI-powered verification and automation for financial processes, including audit, accounting, compliance, and deal due diligence.
AI & Machine LearningEnterprise SoftwareFintechPalo Alto, US
Sudha Valluru(Founder)inLucas Tsao(Founder)Stephen V(Founder)Zhanibek Datbayev(Founder)in
Co-investorsCoalition OperatorsMVP VenturesGeneral CatalystWalden Catalyst
Cambridge, US
Nathan Wilson(Director)inThomas Copeman(Executive Officer, Director)inJana Eggers(Executive Officer, Director)inJohn di Bartolomeo(Director)Randy Work(Director)
BoardPeter de Roetth(Director)
Nema Health provides trauma-focused mental health treatment for patients with PTSD and C-PTSD, using Cognitive Processing Therapy (CPT) delivered by licensed therapists.
Digital HealthHealthtechMental Health
Isobel Rosenthal, MD, MBA(Founder)in
Co-investorsCVS Health VenturesGreyMatterOptum Ventures
HealthtechBranford, US
Sofia Noori(Executive Officer, Director)Mariam Malik(Executive Officer)in
BoardLaura Veroneau(Director)Adrienne Rosenthal(Director)
Co-investorsDeerfield Management CompanyOptum Ventures
Nomad Health operates an online marketplace that matches travel nurses and allied health clinicians with temporary healthcare jobs based on their profiles and preferences.
Digital HealthHealthtechMarketplacesNew York, US
Alexander Nazem(Director)inMaxwell Laurans(Director)Alexi Nazem(Co-Founder & Board Member)inJustin Lambert(CEO)inWilliam Eager(Vice President of Engineering)Alexander Pease(Vice President of Product)
Co-investorsAlleyCorpIcon VenturesAdams Street PartnersFirst Round CapitalHealthQuest CapitalPolaris Partners+1 more
On Belay provides tools, resources, and guidance to support primary care teams in transitioning to value-based care models and strengthening their practices across the United States.
Enterprise SoftwareHealthtechSaaS
Co-investorsLongitude CapitalMaverick Ventures
OncoveryCare develops survivorship care solutions for cancer survivors, addressing the medical and quality-of-life needs of people living after cancer treatment.
Digital HealthHealthtechMedical DevicesBoston, US
Hil Moss(Founder)inHil Moss, MBA/MPH(Co-Founder & CEO)Justin Grischkan, MD(Co-Founder & CMO)
Co-investorsF-Prime CapitalFlare Capital PartnersOncology VenturesTechstars
Oort provided identity security and threat detection, now part of Cisco as Cisco Identity Intelligence, offering visibility into an organization's identity population and helping move toward passwordless authentication.
CybersecurityEnterprise SoftwareSaaSHarvard, US
Matthew Caulfield(Executive Officer, Director)
Co-investors645 VenturesCisco InvestmentsDreamit VenturesEnergy Impact PartnersArgon VenturesEnergy Revolution Ventures+2 more
Portrait is an AI-powered investment research platform that processes filings, transcripts, and news to help investment firms discover companies, conduct deep research, and monitor investment theses.
AI & Machine LearningFintechSaaS
Co-investorsUnusual Ventures
Portrait is an AI research platform for investment analysts that turns filings, transcripts, and news into structured, fully-cited research reports, qualitative-plus-quantitative idea screens, and always-on thesis monitoring.
AI & Machine LearningFintechSaaS
Co-investorsUnusual Ventures
Portrait is an AI-powered research platform that analyzes thousands of filings, transcripts, and news to generate investment theses and insights for investment firms.
AI & Machine LearningEnterprise SoftwareFintech
Promethium builds an AI Insights Fabric that enables enterprises to query, understand, and trust data instantly across disconnected systems, making data instantly usable for AI, analytics, and business decisions.
AI & Machine LearningData & InfrastructureEnterprise SoftwareLas Vegas, US
Devon Scheg(Executive Officer, Director)Daniel Werth(Executive Officer, Director)Xavier Morgan-Lange(Executive Officer, Director)
Co-investorsInsight PartnersZetta Venture Partners
Quell provides ransomware containment software that detects and halts encryption attacks in real-time, allowing businesses to maintain operations without recovery downtime.
CybersecurityEnterprise Software
Security platform generating behavioral fingerprints to detect zero-day attacks across software supply chain and cloud infrastructure.
Brooke M.(Founder)inJimmy Mesta(Founder)in
Co-investorsCheyenne VenturesGula Tech AdventuresTRANSFORMATION CAPITAL
Brooke M.(Founder)in
Co-investorsForgePoint CapitalVertex VenturesLytical Ventures
Randori provides security threat detection and prevention services.
CybersecurityPalo Alto, US
Co-investorsfama Ventures, LLCHarmony Partners
RapidFire AI provides an open experimentation engine that orchestrates datasets and LLM pipelines for AI practitioners to customize and test AI models with greater speed and efficiency.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareMountain View, US
Arun Kumar(Co-founder)inJack Norris(Co-founder)inPradyumna Sridhara(Founder)inJohn Schroeder(Director)
Co-investorsAI Fund
Redox provides healthcare data integration infrastructure that enables organizations to ingest EHR and legacy data into cloud-based clinical repositories and third-party healthcare applications.
Cloud ComputingData & InfrastructureDigital HealthEnterprise SoftwareHealthtechMadison, US
Niko Skievaski(Cofounder)in
Co-investorsAvenir Growth CapitalFlybridge Capital PartnersHealthX VenturesRRE VenturesCultivation Capital
RELAI builds a continual learning infrastructure system that enables AI agents to improve themselves through experience by converting failures and feedback into continuous optimization across prompts, tools, memory, and models.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareBethesda, US
Soheil Feizi(Founder)inLaurent Py(Director)
BoardKevin Wang(Director)in
Co-investorsNon Sibi VenturesTEDCO
Roon Cyber provides cybersecurity services focused on application security for enterprise customers.
AI & Machine LearningCybersecurityEnterprise Software
RoundUp.org lets individuals and businesses automatically round up purchases made on eligible Visa or Mastercard cards to the next dollar and direct the spare change to any of over 1.3 million U.S. nonprofits.
FintechImpact & Social Good
Co-investorsDuke Capital PartnersAlbum VCIQ CapitalKarma VenturesSMBC Asia Rising Fund
Sevco Security, now part of Arctic Wolf, provides an exposure management platform (branded Aurora) that discovers an organization's full attack surface, prioritizes vulnerabilities and misconfigurations by risk, and guides remediation.
CybersecurityEnterprise SoftwareSaaSAustin, US
Jeffrey Guy(Executive Officer, Director)Mike Viscuso(Director)Kevin Cunningham(Director)Lori Fitzpatrick(Executive Officer)Greg Fitzgerald(Director)
BoardGreg Dracon(Director)in
Co-investorsfama Ventures, LLCSyn Ventures Seed Management LlcAccompliceSYN Ventures
New York City, US
Jason Davis(Founder)
Co-investorsPolaris Partners
Simon AI provides customer data and personalization tools to marketing teams for driving one-to-one customer messaging across touchpoints.
AI & Machine LearningData & InfrastructureMarketing TechSaaSBrooklyn, US
Jason Davis(CEO)inMatt Walker(CTO)in
Co-investorsCommerce VenturesPolaris PartnersSlow Ventures
Tausight provides Active Containment technology that stops ransomware attacks in real-time by monitoring encryption and preventing operational disruption, eliminating downtime during attacks.
Cybersecurity
David Ting(Founder)in
Co-investorsFlare Capital PartnersPolaris Partners
Tools for proactive monitoring of open and dark web for stolen digital assets.
Baltimore, US
Michael Moore(Executive Officer, Director, Promoter)Daniel Rogers(Executive Officer, Director, Promoter)
BoardDavid Oros(Director)E. Wayne Jackson III(Director)Jack Dunn(Director)
Co-investorsGlasswing VenturesTCP Venture Capital
TextQL builds AI data analyst agents, led by an agent named Ana, that let business teams query their existing data warehouses and SaaS tools in plain English through interfaces like Slack, dashboards, and scheduled playbooks.
AI & Machine LearningData & InfrastructureEnterprise SoftwareSan Francisco, US
Mark Hay(Founder)
Co-investorsHawk Hill VenturesHOF CapitalPage One VenturesFlare Capital Partners
Theta builds simulation environments and training infrastructure for AI agents specialized to perform enterprise workplace tasks.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US
Rayan Garg(Founder)inTanmay Sharma(Founder)inGurvir Singh(Founder)in
Co-investorsScribble VenturesY Combinator
ThreatX, now part of A10 Networks, provides a cloud-based web application and API protection (WAAP) platform that offers real-time traffic visibility, behavioral threat detection, and automated risk-based blocking.
Cloud ComputingCybersecuritySaaSAustin, US
Edwin Bret Settle(Executive Officer, Director)Andrius Useckas(Executive Officer)in
Co-investorsAccess Venture PartnersCrawley VenturesService Provider CapitalStout Street CapitalAccess VenturesGrotech Ventures
Valerie Health provides AI-powered practice management software for independent medical practices to automate administrative workflows and reduce operational burden.
AI & Machine LearningDigital HealthHealthtechSan Francisco, US
Pete Shalek(Co-founder)inNitin Joshi(Co-Founder & CTO)inPeter Shalek(Co-Founder & CEO)in
Co-investorsPrimary Venture PartnersRedpoint VenturesBoxGroupGeneral CatalystKarman VenturesWaybury Capital
Data control platform ensuring regulatory compliance for third-party service access.
Boston, US
Jonas Hellgren(Chief Executive Officer)in
Co-investorsNew Science Ventures
Veracode provides an application security platform for scanning, identifying, and remediating software flaws across the software development lifecycle and supply chain.
CybersecurityDeveloper ToolsEnterprise SoftwareBurlington, US
Christopher Wysopal(Director, Executive Officer)Edward Goldfinger(Executive Officer)Dean J. Breda(Executive Officer)inRobert Brennan(Executive Officer, Director)
BoardRobert D. Ward(Director)Maria Cirino(Director)in
Co-investorsAccompliceAtlassian VenturesAviso VenturesBright Pixel CapitalCross Creek AdvisorsDot Capital+2 more
Virtudent provides on-site and virtual dental care, delivering hygienist visits at workplaces and teledentistry consultations with licensed dentists as part of employee wellness programs.
Digital HealthHealthtechWellness & FitnessBoston, US
Hitesh Tolani(Executive Officer, Director)in
BoardNirav Desai(Director)
Co-investorsSPRINGROCK VENTURES
Vitalize provides an AI platform for health systems that unifies staffing, scheduling, and capacity management to optimize labor operations.
AI & Machine LearningEnterprise SoftwareHealthtechSaaSSan Francisco, US
Veeraj Shah(Founder)inSanketh Andhavarapu(Founder)in
Co-investorsDorm RoomMemorialCare Innovation FundY CombinatorWisdom Ventures
Wayspring provides healthcare management and engagement services for individuals with substance use disorder and serious mental illness, serving health plans and their provider networks.
Digital HealthEnterprise SoftwareHealthtech
Co-investorsCVS Health VenturesHLM Venture PartnersOak HC/FT
WelbeHealth operates a Program of All-Inclusive Care for the Elderly (PACE) that provides integrated medical and social services to seniors, including primary care, dental, vision, hearing, in-home care, transportation, and social activities.
Digital HealthHealthtechWellness & FitnessCalifornia, US
Si France, MD(Founder)inCLANCY SI FRANCE(MANAGER AND CHIEF EXECUTIVE OFFICER OF ISSUER)
BoardLIAM DONOHUE(MANAGER OF ISSUER)inADAM GROFF(MANAGER OF ISSUER)inMICHAEL ZUBKOFF(MANAGER OF ISSUER)JONATHAN LIM(MANAGER OF ISSUER)
Co-investorsF-Prime CapitalGeneral AtlanticLongitude Capital
Wellist operates a resource matching platform that helps employers and healthcare providers optimize benefits and support programs.
Enterprise SoftwareHealthtechHR TechSaaS
Ashley Reid(Founder)in
Co-investorsMemorialCare Innovation Fund
Windspeed Ventures is a venture capital and advisory firm founded in 1999 that provides strategic and operational guidance to entrepreneurs, drawing on the founding partners' combined experience in technology operations, high-tech marketing, and investment banking.
Enterprise SoftwareSaaSSector Agnostic
Steven E. Karlson(General Partner)Daniel H. Bathon, Jr.(General Partner and Chairman)John Bullock(Managing Partner)
Co-investorsGrandBanks Capital
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Attend.com, Inc.AuthAirCloudHealth TechnologiesImcs GroupJistoLexumoRapid Focus SecurityAbilToAdtuitiveAnnum HealthAxial HealthcareBedrock DataBendBusiness Intelligence AdvisorsChosen SecurityConnotateCorvusDigitalSmithsEdgewise NetworksEquip HealthFamilyWellFamilyWell HealthGamalonHealth DialogHelm HealthHurdleMementoMythicaOptarosPwnie ExpressThingMagicThreatGRIDTraversalTrilioUsefulWellaware
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 27
IPOs and acquisitions across the tracked portfolioCompass (NYSE:COMP)NYSE: COMPKalturaNASDAQ: KLTRAuthAiracq. by LogMeInCloudHealth Technologiesacq. by VMwareAdtuitiveacq. by EtsyBedrock Dataacq. by FormstackBendacq. by Webster FinancialChosen Securityacq. by PGPConnotateacq. by Import.io ,Copatientacq. by MebexCorvusacq. by TravelersDigitalSmithsacq. by TivoEdgewise Networksacq. by ZscalerHealth Dialogacq. by BupaIora Healthacq. by One MedicalKeeboacq. by WagestreamLaudioacq. by Ascend LearningMasheryacq. by TIBCOMementoacq. by FISOptarosacq. by IPGPwnie Expressacq. by Outpost24Terbium Labsacq. by DeloitteThingMagicacq. by TrimbleThreatGRIDacq. by Cisco SystemsVaultiveacq. by CyberArkVeracode, Inc.acq. by CA TechnologiesWellawareacq. by Healthsense
Portfolio news
latest coverage across their companies
Roundup · localsamosa.com · Sep 11, 2026
Indico Data · fintech.global · Aug 17, 2026
Heartbeat · businesstimes.com.sg · Aug 16, 2026
Mindgard · eu-startups.com · Aug 13, 2026
IQ Capital · siliconangle.com · Aug 13, 2026
Genesis Computing · intelligence360.news · Aug 6, 2026
Compass (NYSE:COMP) · ng.investing.com · Aug 4, 2026
Reltio · fortuneindia.com · Jul 17, 2026
Fund performance · per public LP disclosures
as of Nov 2025| Fund | Vintage | Committed | Net IRR | TVPI | DPI |
|---|---|---|---|---|---|
| POINT 406 VENTURES I, L.P.LPs: Employees' Retirement System of Rhode Island | — | — | 6.4% | 1.57x | 1.36x |
Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).
Frequently asked questions
- How many investments has .406 Ventures made?
- .406 Ventures has 93 tracked investments, 28 of which have exited via acquisition or IPO, including 4 dated in the last 24 months.
- What stage does .406 Ventures invest at?
- .406 Ventures invests at the Seed, Series A, Series B, Series C, Growth stages.
- What is .406 Ventures's typical check size?
- .406 Ventures typically writes checks of $1M – $4M.
- What sectors does .406 Ventures focus on?
- .406 Ventures focuses on AI & Machine Learning, Cybersecurity, Data & Infrastructure, Digital Health, Healthtech, Sector Agnostic.
- Where is .406 Ventures located?
- .406 Ventures is headquartered in Boston, US.
- Does .406 Ventures lead rounds?
- Yes, .406 Ventures leads investment rounds.
- Who does .406 Ventures co-invest with?
- .406 Ventures most often shares deals with F-Prime Capital, Optum Ventures, CVS Health Ventures, among 146 tracked co-investors.
Media · Podcasts & interviews
featuring the teamGraham Brooks, Partner at .406 Ventures - The VentureFizz Podcast
VentureFizz · Graham Brooks
The HLTH Daily Show Ft. Payal Agrawal Divakaran, .406 Ventures, Partner
Chitra Nawbatt · Payal Agrawal Divakaran
Payal Agrawal Divakaran, Partner at .406 Ventures - Top Healthcare Investor
Top Startup Series · Payal Agrawal Divakaran
Maria Cirino - Managing Partner at .406 Ventures (Full Interview)
TAG Infosphere · Maria Cirino
.406 Ventures' Maria Cirino for Boston UpFront
BostInno · Maria Cirino
Images
Co-investors · 55
F-Prime Capital is an early-stage-focused investment firm backing companies across life sciences, technology, healthtech and services, and crypto.
Flare Capital Partners is a healthcare technology-focused venture firm that partners with founders building companies to improve outcomes, lower costs, and reshape healthcare delivery.
General Catalyst is a venture capital firm operating as a partnership focused on company building and accelerating the growth of the businesses it backs.
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
Accomplice is a venture capital firm that has backed early-stage companies across sectors, having been part of the origin stories of companies like AngelList, DraftKings, Patreon and WHOOP.
RRE Ventures is a boutique early-stage venture capital firm that backs founders across sectors, combining decades of experience with AI-driven analysis throughout the investment lifecycle.
Echo Health Ventures is a strategic venture capital and growth equity investor that partners with health care companies to help build and scale their innovations nationally.
Cisco Investments is the corporate venture arm of Cisco, investing in, merging with, and acquiring fast-growing technology startups for over thirty years.
Glasswing Ventures is an early-stage venture capital firm that supports startups through its Building Partners model, providing operational expertise across go-to-market, product, engineering, and finance.
Sandbox Industries is an investment firm that fosters innovation in the healthcare and insurance industries, partnering with corporate strategic investors as limited partners alongside financial investors and portfolio companies.
Uncork Capital (formerly SoftTech VC) is a seed-stage venture firm that invests early in founders, with a focus on AI-native companies building leverage and scale.
Sapphire Ventures partners with expansion-stage enterprise software companies aiming to become category leaders.
▶43 more co-investors
Scale Venture PartnersObvious VenturesZetta Venture PartnersEvolution Equity PartnersFounders Circle CapitalEight Roads VenturesSequoia CapitalFirst Round CapitalFlybridge Capital PartnersCrosslink CapitalNexus Venture PartnersEnergy Impact PartnersHighland Capital PartnersNGP CapitalNational Grid PartnersOpenView Venture PartnersAscension VenturesaMoonLytical VenturesBlueCross BlueShield Venture PartnersBenchmarkB Capital GroupKapor CapitalMeritech Capital PartnersPractical Venture CapitalDCM VenturesBallistic VenturesAnorak VenturesVitalStage VenturesEndeavor CatalystPhoenix CourtVertex Ventures Sea Management Pte. Ltd.Gutbrain VenturesAllegisCyber CapitalCambridge Innovation CapitalTop Tier Capital PartnersGeneration Investment ManagementInnospark VenturesMonk's Hill VenturesNew Markets Venture PartnersSeae VenturesInnova Memphis, Inc.Omidyar Technology Ventures
Firms observed investing alongside .406 Ventures, from public investor directories. Shared companies are the overlap with .406 Ventures's recorded portfolio.
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