Twine Ventures
Venture capitalActively deployingSan Francisco · Pre-Seed–Series A · 2 people tracked
Investment thesis
Twine Ventures backs mission-driven founders at the earliest stages, drawing on the team's operating and investing experience across public health, climate policy, data science, and startup building. The firm emphasizes hands-on partnership, working closely with founders through the messiest early phases and helping with go-to-market strategy and competitive Series A fundraising. Its portfolio spans AI-driven healthcare, home care staffing, medical affairs, vertical AI, and data infrastructure for finance and AI/ML.
Source: firm website, verified Aug 7, 2026.
Team · 2 people
from public directories
What they invest in
from 16 of 29 portfolio companiesHealthtech ×8AI & Machine Learning ×7Digital Health ×7SaaS ×7Advanced Manufacturing ×2Data & Infrastructure ×2Enterprise Software ×2InsurTech ×2
HQs:United States×11
Investments · 29 tracked
founders shown can be your intro pathAlaffia provides an AI platform designed for health plans to automate and optimize claims operations through data extraction, clinical analysis, and triage.
AI & Machine LearningHealthtechInsurTech
TJ Ademiluyi(Cofounder)
Alchemy builds and operates in-house, clinic-owned pharmacies for safety net clinics—including STD clinics, Ryan White Grantees, and FQHCs serving patients with HIV and Hepatitis C—handling physical setup, staffing, compliance, financing, and digital tools.
Digital HealthHealthtechMedical DevicesOklahoma City, US
Mission Viejo, US
Omar Sinno(Executive Officer)Abdellatif Lawand(Executive Officer)Rezaur Rahman(Executive Officer)
CloudCruise provides an AI-powered platform for building and running browser automations, particularly for healthcare workflows like EHR and payer portal integrations.
AI & Machine LearningEnterprise SoftwareHealthtechSaaSSan Francisco, US
Frontier Machines builds FR-1, an AI-powered industrial robot that learns repetitive manual tasks such as packing, bagging, kitting, and assembly at workstations before end-of-line.
Advanced ManufacturingAI & Machine LearningRobotics
Fullscript is a clinical platform for healthcare providers to manage supplements, lab ordering, personalized care plans, and patient adherence within their existing EHR workflows.
Digital HealthHealthtechWellness & Fitness
Nectar builds a utility intelligence platform that aggregates energy consumption data from utility bills and online portals to help companies optimize their energy usage and costs.
Advanced ManufacturingCleantechClimate TechData & InfrastructureEnergyEnterprise SoftwareSaaSSan Francisco, US
Oasys provides practice management and AI-powered documentation software for mental health practitioners and clinics.
Digital HealthMental HealthSaaSSan Francisco, US
Plover is a specialty insurance broker that uses software to quantify exposures, recommend products, and market renewals, helping insurance agents place hard-to-place accounts in the P&C space.
FintechInsurTechSaaS
A platform that enables healthcare providers to order, track, and receive lab test results from multiple laboratory companies through a single dashboard, supporting both in-person and telehealth patients with flexible billing options and EHR integration.
Digital HealthHealthtechSaaS
Tara Viswanathan(Founder)Rosa Hamalainen(Founder)inBen Easton(Founder)
Teiko provides multi-parameter cytometry services for clinical trials, including blood preservation kits (TokuKit), spectral and mass cytometry panels, and data analysis via its Dashboard platform.
BiotechDigital HealthMedical DevicesSalt Lake City, US
Ramji Srinivasan(Executive Officer, Director)inMatthew Spitzer(Director)
BoardVictor Wang(Director)
Waymark builds an AI-powered clinic model for Medicaid populations, using predictive analytics and clinical decision support to identify at-risk patients and coordinate community-based care.
AI & Machine LearningDigital HealthHealthtechSan Francisco, US
Afia Asamoah(Co-Founder and Head of People and Legal)Sanjay Basu(Co-Founder and Head of Clinical)Rajaie Batniji(Co-Founder and CEO)Kelly Coffin(Executive Officer, Director, Promoter)Kevin Williams(Executive Officer)
Zipline is a data infrastructure platform built on the open-source Chronon project that lets engineering teams build, deploy, and monitor real-time data pipelines, features, and embeddings for AI agents and ML models.
AI & Machine LearningData & InfrastructureDeveloper Tools
Nikhil Simha(Co-Founder & CTO)Varant Zanoyan(Co-Founder & CEO)Piyush Narang(Chief Architect)
Frequently asked questions
- What stage does Twine Ventures invest at?
- Twine Ventures invests at the Pre-Seed, Seed, Series A stages.
- What is Twine Ventures's typical check size?
- Twine Ventures typically writes checks of $500K – $750K.
- What sectors does Twine Ventures focus on?
- Twine Ventures focuses on AI & Machine Learning, Climate Tech, Data & Infrastructure, Digital Health, Enterprise Software, Fintech, Healthtech, New Materials, SaaS.
- Where is Twine Ventures located?
- Twine Ventures is headquartered in San Francisco, US.
- Does Twine Ventures lead rounds?
- Twine Ventures typically participates in rounds rather than leading them.
Media · Podcasts & interviews
featuring the teamBuilding a Community and the Future of Venture Capital with Leshika Samarasinghe at Twine Ventures
DrinksWithAVC · Leshika Samarasinghe
Venture with Purpose | Leshika Samarasinghe, Founder and General Partner, Twine Ventures
Day Zero · Leshika Samarasinghe
Working on Things That Matter | Leshika Samarasinghe, Founder and General Partner, Twine Ventures
Day Zero · Leshika Samarasinghe
Opportunities Abound in the Startup Ecosystem | Leshika Samarasinghe, Twine Ventures
Day Zero · Leshika Samarasinghe
The Collaborative Nature of Founding | Leshika Samarasinghe, Twine Ventures
Day Zero · Leshika Samarasinghe
Finding Time to Think and Reflect | Leshika Samarasinghe, Twine Ventures
Day Zero · Leshika Samarasinghe
Images
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