Fundraising Fox
San Francisco · Pre-Seed–Seed · 2 people tracked
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Investment thesis
Twine Ventures focuses on the generational transformation of healthcare and industrials, investing in interdisciplinary teams that leverage unique data insights and AI to modernize legacy industries. The firm positions itself as a first-check investor, backing bold, data-obsessed founders from the very earliest stages of company formation. Framed around transforming human and planetary health, its team combines operating and investing experience across public health, climate policy, data science, and startup building, and emphasizes hands-on partnership with founders on go-to-market strategy and preparing for competitive Series A fundraises.
Source: firm website, verified Sep 27, 2026.
Team · 2 people
from public directories
What they invest in
from 22 of 38 portfolio companiesDigital Health ×10Healthtech ×10AI & Machine Learning ×9SaaS ×9Enterprise Software ×4Fintech ×3InsurTech ×3Advanced Manufacturing ×2
HQs:United States×20
Who they back
founder profiles across 18 portfolio companiesFounding team size:solo founder×52 founders×63 founders×44+ founders×3
Where their founders studiedfrom 26 founders with education data
Massachusetts Institute of Technology ×3Stanford University ×3Center for Digital Technology and Management (CDTM) ×2Columbia University ×2Stanford University School of Medicine ×2Technical University of Munich ×2University of California, San Francisco ×2University of Oxford ×2
What their founders studiedfrom 27 founders with field-of-study data
Computer Science ×11Engineering ×6Business & Management ×5Finance & Accounting ×3Life Sciences ×3Politics & Policy ×3Design & Architecture ×2Humanities ×2
Where their founders worked beforefrom 29 founders with career history
Stanford University ×5LinkedIn ×4Google ×3Airbnb ×2First Round Fast Track ×2Microsoft ×2Oracle ×2
Accelerator rootsportfolio companies that came through a program
2 founders hold a PhD · 4 hold an MBA (of 29 with degree data)
Investments · 38 tracked
founders shown can be your intro pathBy year:2026 · 32025 · 12024 · 22022 · 12021 · 12020 · 12016 · 110 dated
Airship builds software for home services trades businesses, aimed at increasing big-ticket job revenue for roll-up platforms and independent brands.
Construction TechEnterprise SoftwareSaaSSales TechUnited States, US
Craig Battin(Founder)inScott Kveton(Founder)Steven Osborn(Founder)
Co-investorsCity LightFour Acres CapitalLorimer VenturesQED InvestorsTerrence YangAugust Capital+3 more
Alaffia invests in and partners with African communities on development projects focused on education, maternal health, and environmental sustainability.
ConsumerImpact & Social Good
Olowo-n'djo Tchala(Founder)in
Co-investorsNew VoicesOssian CapitalTRANSFORMATION CAPITAL1984 Ventures Management, LlcAperture Venture CapitalFirstMark Capital+3 more
Alaffia offers Autodor, an AI platform that pre-processes prior authorization requests for health plan utilization management teams by extracting clinical data, applying policy-based logic, and generating human-reviewed case summaries.
AI & Machine LearningDigital HealthHealthtechInsurTech
TJ Ademiluyi(Founder)inAdun Akanni(Founder)
Co-investorsAnthemis VentureAperture Venture CapitalEntrepreneurs Roundtable Accelerator (ERA)FirstMark CapitalGingerbread CapitalRemarkable Ventures+5 more
Alchemy Health publishes a state-by-state tracker of the federal Rural Health Transformation Program (RHTP), summarizing each state's funding allocation, current and upcoming funding opportunities, and engagement events.
Digital HealthHealthtechMedical DevicesSaaSOklahoma City, US
Sid Viswanathan(Founder & Co-CEO)inPeter Park(Founder & Co-CEO)inSusie Crowe(Founder & Chief Pharmacist)in
Co-investorsAndreessen HorowitzSpringbank
Alden builds a system of AI agents for home care providers that automate care coordination tasks such as filling shift callouts, monitoring clock in/out and punctuality, and planning matched caregiver rosters.
AI & Machine LearningDigital HealthHealthtech
Rose Huang(Founder)in
Co-investorsEquitage Ventures, L.L.C.Flare Capital Partners
Pricing intelligence for EV charging infrastructure
Palo Alto, US
Lucas Ackerknecht(Founder)Phil Stahlfeld(Founder)
Co-investorsStarshotWorkshop Venture Partners
Apella provides real-time operating room monitoring and predictive analytics through computer vision and AI integration with EHR systems, helping surgical teams detect delays, optimize scheduling, and improve OR efficiency.
AI & Machine LearningDigital HealthHealthtech
Co-investorsK2 HealthVenturesLayout VenturesOPAMP CAPITALCasdin CapitalHighlandXOperator Partners+2 more
Ava offers a credit-building app for U.S. consumers, including a Credit Builder Mastercard, a Save & Build Credit secured loan, and rent and utility reporting.
ConsumerFintechSan Francisco, US
Omar Sinno(CEO)inAbdellatif Lawand(Co-Founder & CTO)Reza Rahman(President, Growth)inAbed Lawand(CTO)Abed L(Founder)Ravneet Singh Khalsa(Founder)in
Co-investorsGreylock PartnersSure VenturesTransform VCWestern Technology InvestmentBurst Capital
CloudCruise provides an AI-powered platform for building and running browser automations, particularly for healthcare workflows like EHR and payer portal integrations.
AI & Machine LearningEnterprise SoftwareHealthtechSaaSSan Francisco, US
Adrian Ziegler(CEO)inFelix Martin Eckert(CTO)inVere WhittomeJimmy Teng(GTM)
Co-investorsFloating PointMeridian Street CapitalY CombinatorAndreessen HorowitzMadv Ventures Gmb H & Co. KGRefract Ventures
Colla Health provides a behavioral health program for cancer patients, staffing clinicians with psycho-oncology training who deliver evidence-based therapies such as CBT and ACT.
Digital HealthHealthtechMental Health
Beau Palin(Founder)in
Co-investors2048 VenturesCity LightMenlo VenturesPioneerOncology Ventures
Compliance software for food and agriculture
Ben Harms(Co-founder)inMatt Meisner(Co-founder)in
Co-investorsFikaFormus CapitalInspired Capital
Frontier Machines builds FR-1, an AI-powered industrial robot that learns repetitive manual tasks such as packing, bagging, kitting, and assembly at workstations before end-of-line.
Advanced ManufacturingAI & Machine LearningRobotics
Co-investorsSwitch Ventures
Fullscript is a clinical platform for healthcare providers to manage supplements, lab ordering, personalized care plans, and patient adherence within their existing EHR workflows.
Digital HealthHealthtechWellness & Fitness
Kyle Braatz(Founder)in
Co-investorsAscension VenturesDefy PartnersHGGCLeonard GreenAltas PartnersL Catterton
Online grocer for lower income communities in Mexico
San Francisco, US
Uri Pomerantz(Executive Officer, Director)Nicolas S. Bergengruen(Founder)in
BoardDan Kimerling(Director)in
Co-investorsAngel Collective Opportunity FundClocktower VenturesBain Capital VenturesDeciensPrecursor Ventures
Nectar builds a utility intelligence platform that aggregates energy consumption data from utility bills and online portals to help companies optimize their energy usage and costs.
Advanced ManufacturingCleantechClimate TechData & InfrastructureEnergyEnterprise SoftwareSaaSSan Francisco, US
Allen Wang(Founder)inKatherine He(Founder)inAndrew Hollis(Founder)Jackson Horne(Founder)Trevor Larson(Founder)Jesse Cheng(Account Executive)
Co-investorsCollaborative FundFormus CapitalSoma CapitalY CombinatorChinaRock Capital ManagementClimate Capital+12 more
Oasys is a gaming-focused blockchain built by gaming industry veterans, designed with user experience at its core through features like zero gas fees and fast transaction finality.
Crypto & Web3Deep TechGaming
Co-investorsCeras VenturesDigital Finance GroupFenbushi CapitalHyperithmNonagonSerafund+8 more
Oasys provides practice management and AI-powered documentation software for mental health practitioners and clinics.
Digital HealthMental HealthSaaSSan Francisco, US
Co-investorsBetter Ventures Central LlcPathlight Ventures1984 Ventures Management, Llc
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Pikl is developing staffing technology, described by the company as still in a pre-launch phase.
HR TechSaaSDenver, US
Karson Humiston(CEO and Director)in
BoardMorgan Blumberg(Director)
Co-investorsColle Capital PartnersLevel One FundBain CapitalSeedrs
Plover is a specialty insurance broker that uses software to quantify exposures, recommend products, and market renewals, helping insurance agents place hard-to-place accounts in the P&C space.
FintechInsurTechSaaSNew York City, US
Ranajay Sen(Founder)inTommy Peeples(Founder)Max Clarke(Executive Officer, Director)Sen Ranajay(Executive Officer, Director)
Postal provides AI-powered mail management and virtual mailbox services for remote-first and distributed businesses, handling mail scanning, analysis, and compliance workflows.
AI & Machine LearningEnterprise SoftwareFintechInsurTechSaaSNew York City, US
Max Clarke(Founder)inTommy Peeples(Founder)inErik Kostelnik(Founder)Ranajay Sen
Co-investorsOlive Tree CapitalSoma CapitalY CombinatorBoxGroupGoldcrest CapitalLiquid Ventures+3 more
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San Francisco, US
Yibo Ling(Founder)Michael Manapat(Founder)
Co-investorsBasis Set VenturesSarah SmithThirdstream PartnersConvictionEmergence Capital PartnersGradient Ventures+1 more
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A platform that enables healthcare providers to order, track, and receive lab test results from multiple laboratory companies through a single dashboard, supporting both in-person and telehealth patients with flexible billing options and EHR integration.
Digital HealthHealthtechSaaSSan Francisco, US
Tara Viswanathan(Founder)inRosa Hamalainen(Founder)inBen Easton(Founder)in
Co-investors3cubed VenturesASDF VenturesBessemer Venture PartnersFirst Round CapitalHustle FundJames Beshara Fund+11 more
Teiko provides CLIA-validated high-dimensional cytometry services—including spectral flow and mass cytometry panels, blood preservation kits, gating, and a data analysis dashboard—for immune cell profiling in clinical trials.
BiotechDigital HealthHealthtechSalt Lake City, US
Ramji Srinivasan(Executive Officer, Director)inMatt(Co-founder)inMatthew Spitzer(Director)
BoardVictor Wang(Director)in
Co-investorsCivilization Ventures Management, LlcHAWKTAILHOF CapitalTau VenturesWestern Technology InvestmentEPIC VENTURES+1 more
Verse provides a faster path to grid power for data centers, helping AI infrastructure companies and large energy users bypass interconnection queue delays to come online sooner.
AI & Machine LearningCleantechEnergySan Francisco, US
Seyed H. Madaeni, Ph.D.(Founder)inAmit Mukherjee(Director)Andy Wheeler(Director)
BoardAndy Chen(Director)Matthew Penfold(Director)
Co-investorsBessemer Venture PartnersCIVCoatue ManagementCollaborative FundGV (Google Ventures)Innovacom+1 more
Waymark builds an AI-powered clinic model for Medicaid populations, using predictive analytics and clinical decision support to identify at-risk patients and coordinate community-based care.
AI & Machine LearningDigital HealthHealthtechSan Francisco, US
Afia Asamoah(Founder)inSanjay Basu(Co-Founder and Head of Clinical)inRajaie Batniji(Co-Founder and CEO)inRajaie Batniji MD DPhil(Founder)inKelly Coffin(Executive Officer, Director, Promoter)Kevin Williams(Executive Officer)
Co-investorsAcumen AmericaAndreessen HorowitzCVS Health VenturesEnsemble LabsLux CapitalNew Enterprise Associates (NEA)+1 more
Zipline is a data infrastructure platform built on the open-source Chronon project that lets engineering teams build, deploy, and monitor real-time data pipelines, features, and embeddings for AI agents and ML models.
AI & Machine LearningData & InfrastructureDeveloper ToolsUnion City, US
Nikhil Simha Raprolu(Executive Officer, Director, Promoter)Nikhil Simha(Co-Founder & CTO)inVarant Zanoyan(Co-Founder & CEO)inPiyush Narang(Chief Architect)in
BoardChris Zeoli(Director)in
Co-investorsBoxGroupMaterialized View CapitalWingAndreessen HorowitzBaillie GiffordFidelity Investments+8 more
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Covalent TechnologiesCovalentmarketDigital BiologyNexus IntelligenceQuantum ElectricStealth DataStealth FintechStealth HealthcareStealth RoboticsWaltz Health
Portfolio news
latest coverage across their companies
Fullscript · finance.yahoo.com · Sep 10, 2026
CloudCruise · ycombinator.com · Jun 23, 2026
Verse · finsmes.com · Jun 18, 2026
Apella Technology · finsmes.com · Jan 9, 2026
Oasys AI First EHR Health · thesaasnews.com · Jan 8, 2026
Ava Finance · FinTech Global · Oct 27, 2025
Zipline · finsmes.com · Aug 19, 2025
Frequently asked questions
- How many investments has Twine Ventures made?
- Twine Ventures has 38 tracked investments, including 4 dated in the last 24 months.
- What stage does Twine Ventures invest at?
- Twine Ventures invests at the Pre-Seed, Seed stages.
- What is Twine Ventures's typical check size?
- Twine Ventures typically writes checks of $500K – $750K.
- What sectors does Twine Ventures focus on?
- Twine Ventures focuses on Advanced Manufacturing, AI & Machine Learning, Biotech, Climate Tech, Data & Infrastructure, Digital Health, Energy, Enterprise Software, Fintech, Healthtech, InsurTech, New Materials, Robotics, SaaS.
- Where is Twine Ventures located?
- Twine Ventures is headquartered in San Francisco, US.
- Does Twine Ventures lead rounds?
- Yes, Twine Ventures leads investment rounds.
- Who does Twine Ventures co-invest with?
- Twine Ventures most often shares deals with Andreessen Horowitz, Bessemer Venture Partners, City Light, among 78 tracked co-investors.
Media · Podcasts & interviews
featuring the teamBuilding a Community and the Future of Venture Capital with Leshika Samarasinghe at Twine Ventures
DrinksWithAVC · Leshika Samarasinghe
Finding Time to Think and Reflect | Leshika Samarasinghe, Twine Ventures
Day Zero · Leshika Samarasinghe
Finding Good Potential Partnerships | Leshika Samarasinghe, Twine Ventures
Day Zero · Leshika Samarasinghe
Venture with Purpose | Leshika Samarasinghe, Founder and General Partner, Twine Ventures
Day Zero · Leshika Samarasinghe
Working on Things That Matter | Leshika Samarasinghe, Founder and General Partner, Twine Ventures
Day Zero · Leshika Samarasinghe
Opportunities Abound in the Startup Ecosystem | Leshika Samarasinghe, Twine Ventures
Day Zero · Leshika Samarasinghe
Images
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