San Francisco · Pre-Seed–Series A · 2 people tracked
Investment thesis
Twine Ventures partners with early-stage, interdisciplinary founders who leverage unique data insights and AI to transform legacy industries, with a focus on healthcare and industrials undergoing generational change. The firm positions itself as a first-check investor, backing bold, data-obsessed teams from the very beginning of their journey. Its partners bring operating and investing experience across public health, US climate policy, data science at major technology companies, and founding purpose-driven startups. They emphasize a hands-on, long-term approach, working closely with founders on go-to-market strategy and Series A fundraising.
Source: firm website, verified Aug 11, 2026.
Team · 2 people
from public directories
What they invest in
from 21 of 38 portfolio companiesDigital Health ×10Healthtech ×10AI & Machine Learning ×8SaaS ×8Enterprise Software ×3Advanced Manufacturing ×2Cleantech ×2Consumer ×2
HQs:United States×18
Who they back
founder profiles across 16 portfolio companiesFounding team size:solo founder×72 founders×53 founders×14+ founders×3
Where their founders studiedfrom 15 founders with education data
Massachusetts Institute of Technology ×3Center for Digital Technology and Management (CDTM) ×2Stanford University ×2Technical University of Munich ×2University of California, San Francisco ×2University of Oxford ×2Yale University ×2
Where their founders worked beforefrom 17 founders with career history
Stanford University ×3Airbnb ×2
Accelerator rootsportfolio companies that came through a program
Investments · 38 tracked
founders shown can be your intro pathBy year:2026 · 22025 · 12024 · 12021 · 12020 · 12016 · 17 dated
Airship builds software for home services trades businesses, aimed at increasing big-ticket job revenue for roll-up platforms and independent brands.
Construction TechEnterprise SoftwareSaaSSales TechUnited States, US
Craig Battin(Founder)in
Co-investorsCity LightFour Acres CapitalLorimer VenturesQED InvestorsAugust CapitalFoundry+1 more
Alaffia invests in and partners with African communities on development projects focused on education, maternal health, and environmental sustainability.
ConsumerImpact & Social Good
Olowo-n'djo Tchala(Founder)in
Co-investorsNew VoicesOssian CapitalTRANSFORMATION CAPITAL1984 Ventures Management, LlcAperture Venture CapitalFirstMark Capital+3 more
Alaffia offers Autodor, an AI platform that pre-processes prior authorization requests for health plan utilization management teams by extracting clinical data, applying policy-based logic, and generating human-reviewed case summaries.
AI & Machine LearningDigital HealthHealthtechInsurTech
TJ Ademiluyi(Cofounder)in
Co-investorsAnthemis VentureEntrepreneurs Roundtable Accelerator (ERA)FirstMark CapitalGingerbread CapitalRemarkable VenturesTau Ventures
Tech-enabled pharmacy for underserved populations
Alchemy Health publishes a state-by-state tracker of the federal Rural Health Transformation Program (RHTP), summarizing each state's funding allocation, current and upcoming funding opportunities, and engagement events.
Digital HealthHealthtechMedical DevicesSaaSOklahoma City, US
Susie(Founder & Co-CEO)Peter(Founder & Co-CEO)Sid(Founder & Co-CEO)inSid Viswanathan(Founder & Co-CEO)inPeter Park(Founder & Co-CEO)inSusie Crowe(Founder & Chief Pharmacist)
Co-investorsAndreessen HorowitzSpringbank
Alden builds a system of AI agents for home care providers that automate care coordination tasks such as filling shift callouts, monitoring clock in/out and punctuality, and planning matched caregiver rosters.
AI & Machine LearningDigital HealthHealthtech
Co-investorsEquitage Ventures, L.L.C.Flare Capital Partners
Pricing intelligence for EV charging infrastructure
Palo Alto, US
Lucas Ackerknecht(Founder)Phil Stahlfeld(Founder)
Co-investorsStarshotWorkshop Venture Partners
Apella provides an ambient AI platform that connects to the EHR to give hospital surgical teams real-time operating room intelligence, case duration forecasts, and automated documentation.
AI & Machine LearningDigital HealthHealthtech
Co-investorsK2 HealthVenturesLayout VenturesOPAMP CAPITALVensana Capital
Co-investorsBling Capital
Ava offers a credit-building app for U.S. consumers, including a Credit Builder Mastercard, a Save & Build Credit secured loan, and rent and utility reporting.
ConsumerFintechSan Francisco, US
Omar Sinno(Co-Founder & CEO)Abdellatif Lawand(Co-Founder & CTO)Reza Rahman(Co-Founder & President, Growth)Abed LawandAbed L(Founder)Ravneet Singh Khalsa(Founder)
Co-investorsGreylock PartnersSure VenturesTransform VCWestern Technology InvestmentBurst Capital
CloudCruise provides an AI-powered platform for building and running browser automations, particularly for healthcare workflows like EHR and payer portal integrations.
AI & Machine LearningEnterprise SoftwareHealthtechSaaSSan Francisco, US
Adrian Ziegler(Founder)inFelix Martin Eckert(Founder)in
Co-investorsFloating PointMeridian Street CapitalY CombinatorRefract Ventures
Colla Health provides a behavioral health program for cancer patients, staffing clinicians with psycho-oncology training who deliver evidence-based therapies such as CBT and ACT.
Digital HealthHealthtechMental Health
Beau Palin(Founder)in
Co-investors2048 VenturesCity LightMenlo VenturesOncology Ventures
Compliance software for food and agriculture
Co-investorsFikaFormus CapitalInspired Capital
Building sustainable supply chains for chemical ingredients (acquired)
Novel spatial & functional biology platform
Lending aggregation for patient financing
Frontier Machines builds FR-1, an AI-powered industrial robot that learns repetitive manual tasks such as packing, bagging, kitting, and assembly at workstations before end-of-line.
Advanced ManufacturingAI & Machine LearningRobotics
Co-investorsSwitch Ventures
Fullscript is a clinical platform for healthcare providers to manage supplements, lab ordering, personalized care plans, and patient adherence within their existing EHR workflows.
Digital HealthHealthtechWellness & Fitness
Kyle Braatz(Founder)in
Co-investorsAscension VenturesDefy PartnersHGGCLeonard Green
San Francisco, US
Uri Pomerantz(Executive Officer, Director)Nicolas S. Bergengruen(Founder)in
BoardDan Kimerling(Director)in
Co-investorsAngel Collective Opportunity FundClocktower VenturesDeciensPrecursor Ventures
Nectar builds a utility intelligence platform that aggregates energy consumption data from utility bills and online portals to help companies optimize their energy usage and costs.
Advanced ManufacturingCleantechClimate TechData & InfrastructureEnergyEnterprise SoftwareSaaSSan Francisco, US
Allen Wang(Founder)inKatherine He(Founder)in
Co-investorsFormus CapitalY CombinatorMenloMenlo VenturesTrue Ventures
AI platform for manufacturing and industrial automation
Oasys is a blockchain built for gaming, offering gasless transactions and fast play alongside developer tools that handle payments, user acquisition, and cross-game NFTs.
Crypto & Web3Deep TechGaming
Co-investorsCeras VenturesDigital Finance GroupFenbushi CapitalHyperithmNonagonSerafund+5 more
Automating practice management for behavioral health
Oasys provides practice management and AI-powered documentation software for mental health practitioners and clinics.
Digital HealthMental HealthSaaSSan Francisco, US
Co-investorsBetter Ventures Central LlcPathlight Ventures1984 Ventures Management, LlcBetter Ventures
Pikl is developing staffing technology, described by the company as still in a pre-launch phase.
HR TechSaaSDenver, US
Karson Humiston(CEO and Director)in
BoardMorgan Blumberg(Director)
Co-investorsColle Capital PartnersSeedrs
Plover is a specialty insurance broker that uses software to quantify exposures, recommend products, and market renewals, helping insurance agents place hard-to-place accounts in the P&C space.
FintechInsurTechSaaSNew York City, US
Ranajay Sen(Founder)Tommy Peeples(Founder)Max Clarke(Executive Officer, Director)Sen Ranajay(Executive Officer, Director)
A platform that enables healthcare providers to order, track, and receive lab test results from multiple laboratory companies through a single dashboard, supporting both in-person and telehealth patients with flexible billing options and EHR integration.
Digital HealthHealthtechSaaSSan Francisco, US
Tara Viswanathan(Founder)Rosa Hamalainen(Founder)inBen Easton(Founder)
Co-investors3cubed VenturesBessemer Venture PartnersJames Beshara FundMantis CapitalNeythri Futures FundUnion Square Ventures (USV)+5 more
Teiko provides CLIA-validated high-dimensional cytometry services—including spectral flow and mass cytometry panels, blood preservation kits, gating, and a data analysis dashboard—for immune cell profiling in clinical trials.
BiotechDigital HealthHealthtechSalt Lake City, US
Ramji Srinivasan(Executive Officer, Director)inMatt(Co-founder)inMatthew Spitzer(Director)
BoardVictor Wang(Director)in
Co-investorsCivilization Ventures Management, LlcHAWKTAILHOF CapitalTau VenturesWestern Technology Investment
Verse provides a faster path to grid power for data centers, helping AI infrastructure companies and large energy users bypass interconnection queue delays to come online sooner.
AI & Machine LearningCleantechEnergy
Seyed H. Madaeni, Ph.D.(Founder)in
Co-investorsBessemer Venture PartnersCIVCoatue Management
Chicago, US
Co-investorsBlue Venture FundsGV (Google Ventures)Define Ventures
Waymark builds an AI-powered clinic model for Medicaid populations, using predictive analytics and clinical decision support to identify at-risk patients and coordinate community-based care.
AI & Machine LearningDigital HealthHealthtechSan Francisco, US
Afia Asamoah(Co-Founder and Head of People and Legal)Sanjay Basu(Co-Founder and Head of Clinical)Rajaie Batniji(Co-Founder and CEO)Rajaie Batniji MD DPhil(Founder)inSanjay Basu, MD, PhD(Founder)inKelly Coffin(Executive Officer, Director, Promoter)
Co-investorsAndreessen HorowitzCVS Health VenturesLux CapitalNew Enterprise Associates (NEA)
Zipline is a data infrastructure platform built on the open-source Chronon project that lets engineering teams build, deploy, and monitor real-time data pipelines, features, and embeddings for AI agents and ML models.
AI & Machine LearningData & InfrastructureDeveloper ToolsUnion City, US
Nikhil Simha(Co-Founder & CTO)inVarant Zanoyan(Co-Founder & CEO)inPiyush Narang(Chief Architect)in
Co-investorsWing
Portfolio news
latest coverage across their companies
Alden · hokanews.com · Jul 18, 2026
CloudCruise · ycombinator.com · Jun 23, 2026
Nectar · demandgenreport.com · Jun 2, 2026
Colla Health · oncologyventures.substack.com · May 13, 2026
Airship · pluang.com · May 11, 2026
Oasys AI First EHR Health · ascendants.in · Apr 6, 2026
Alaffia · businesswire.com · Feb 3, 2026
Oasys · waya.media · Jan 13, 2026
Frequently asked questions
- How many investments has Twine Ventures made?
- Twine Ventures has 37 tracked investments, including 3 dated in the last 24 months.
- What stage does Twine Ventures invest at?
- Twine Ventures invests at the Pre-Seed, Seed, Series A stages.
- What is Twine Ventures's typical check size?
- Twine Ventures typically writes checks of $500K – $750K.
- What sectors does Twine Ventures focus on?
- Twine Ventures focuses on Advanced Manufacturing, AI & Machine Learning, Climate Tech, Data & Infrastructure, Digital Health, Enterprise Software, Fintech, Healthtech, New Materials, Robotics, SaaS.
- Where is Twine Ventures located?
- Twine Ventures is headquartered in San Francisco, US.
- Does Twine Ventures lead rounds?
- Twine Ventures typically participates in rounds rather than leading them.
- Who does Twine Ventures co-invest with?
- Twine Ventures most often shares deals with Andreessen Horowitz, Bessemer Venture Partners, City Light, among 67 tracked co-investors.
Media · Podcasts & interviews
featuring the teamBuilding a Community and the Future of Venture Capital with Leshika Samarasinghe at Twine Ventures
DrinksWithAVC · Leshika Samarasinghe
Venture with Purpose | Leshika Samarasinghe, Founder and General Partner, Twine Ventures
Day Zero · Leshika Samarasinghe
Working on Things That Matter | Leshika Samarasinghe, Founder and General Partner, Twine Ventures
Day Zero · Leshika Samarasinghe
Opportunities Abound in the Startup Ecosystem | Leshika Samarasinghe, Twine Ventures
Day Zero · Leshika Samarasinghe
The Collaborative Nature of Founding | Leshika Samarasinghe, Twine Ventures
Day Zero · Leshika Samarasinghe
Finding Time to Think and Reflect | Leshika Samarasinghe, Twine Ventures
Day Zero · Leshika Samarasinghe
Images
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