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Pathway Bioventures

Venture capital

Chicago · Pre-Seed–Series A · 5 people tracked

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Investment thesis

Pathway Bioventures focuses on early-stage precision therapeutics companies working on breakthrough life sciences innovations to address important unmet medical needs. The firm backs entrepreneurs pursuing advances in human health through novel therapeutics.

Invests inBiotechHealthtechMedical DevicesChicagoUnited States

Source: firm website, verified Aug 3, 2026.

Stage
Pre-Seed–Series A
HQ
Chicago, US
Instruments
Equity
Founded
2018
Tracked investments
28

Team · 5 people

from the firm's website
Daniel Jacobs· Founder & Managing Partner

Founded Pathway Bioventures in 2018 and leads its operations, investments, diligence, and portfolio support. A cancer researcher with expertise in epidemiology, genomics, and RNA therapeutics; has served as board observer for several biotech firms and as EIR at Yale Ventures. Holds an MPH and PhD from Yale.

Matt Martin· Partner

Partner focused on investments that bring scientific discoveries to the clinic, drawing on 15 years of experience across universities, startups, and early-stage investment groups. Co-founder and early employee of several therapeutics companies and founding CEO of Saros Therapeutics. Holds a PhD in Physics from Carnegie Mellon and an MBA from Chicago Booth.

Jacob Segil· Venture Partner

Research Professor in Mechanical Engineering and Managing Director of the Center for Translational Research at CU Boulder, researching neural interfaces and prosthetic devices. Has founded three medical device companies and is CEO of Afference.

David Hardwicke· Investment Consultant

Biotechnology professional with a background in technology commercialization, program management, and drug development, with prior roles at Novartis Gene Therapies and ONK Therapeutics. Works with Pathway on new investment opportunities in gene editing, RNA therapeutics, and cancer therapies.

Marta New· Strategic Advisor

Founder and CEO of Radyus Research, a preclinical drug development research organization. An experienced drug developer and biotech investor with prior roles at Agent Capital, Baxter Ventures, and Baxalta Ventures. Holds a PhD in immunology and microbiology and an MBA from Northwestern.

What they invest in

from 8 of 28 portfolio companies

Biotech ×7Healthtech ×6Medical Devices ×4AI & Machine Learning ×2Deep Tech ×1Digital Health ×1Hardware ×1New Materials ×1

HQs:United States×6United Kingdom×1

Investments · 28 tracked

founders shown can be your intro path
4BIO

Specialist investor in advanced modalities including cell, gene, RNA, and targeted therapies

4Biocapital4biocapital.com
Afferenceafference.ioin𝕏

Afference develops neurotechnology that enables remote sensory perception through wearable devices, allowing people at a distance to share tactile sensations.

AI & Machine LearningDeep TechHardwareHealthtechCleveland, US

Jacob Segil(Co-founder & CEO)inDustin Tyler(Co-founder & CTO)inTaylor Hurst(Director)

BoardTrevor Zimmerman(Director)

Afference

Leverages neural engineering advances to create an artificial sense of touch

AIRNA Therapeutics

Pioneer in RNA editing therapeutics for rare and common diseases

Axonis Therapeuticsaxonis.usin

Axonis Therapeutics develops medicines targeting KCC2 to restore inhibition in the brain, with a focus on treating neurological disorders including epilepsy and pain.

BiotechMedical DevicesBoston, US

AXONIS Therapeutics

Developing first-in-class precision therapies for neurological disorders

BioGraph55

Developing bispecific antibodies for precision autoimmune applications

Cytospirecytospire.com
Cytospire Therapeutics

Developing pan-gamma delta T cell engagers for solid and hematological cancers

Cytovale

Interrogates biomechanical properties of immune cells to rapidly diagnose sepsis and other severe immunological diseases

Cytovalecytovale.comin

Cytovale develops microfluidic deformability cytometry technology for immune response diagnostics, with a focus on early detection and diagnosis in hospital settings.

BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US

Ajay Shah(Co-founder & CEO)inHenry Tse(Co-founder & Chief Technology Officer)inDino DiCarlo(Director, Promoter)Jack Fuchs(Director, Promoter)in

BoardLindy Fishburne(Director)

Dimension Inx

Creates advanced biomaterials and biofunctional 3D-printed implants for tissue regeneration and repair

Dimensioninxdimensioninx.comin

Dimension Bio is a biotechnology company that designs and manufactures regenerative therapeutics using its BioNidum™ platform to restore tissue function lost to disease, trauma, or aging.

BiotechHealthtechNew Materials

Caralynn Nowinski Collens, M.D.(Co-founder & CEO)Ramille Shah, Ph.D.(Co-founder & CSO)

IpiNovyx Bio

Developing ultra-selective proteasome inhibitors for oncology and autoimmune disease

miRecule

Preclinical RNA-based therapeutics for severe neuromuscular diseases

Mireculemirecule.comin

miRecule is a biotechnology company developing tissue-targeted RNA therapeutics for cancer and muscular dystrophy.

BiotechHealthtechGaithersburg, US

Anthony Saleh(Executive Officer)

Modifi Bio

Preclinical oral medicines that selectively kill cancer cells via direct DNA modification

Modifibiomodifibio.comin𝕏
Nionyx Bionionyxbio.comin𝕏
Nionyx Bio

Developing gene therapies for patients with severe kidney diseases

Ochre Bio

Computational biology and genetic medicine company developing RNA-based therapeutics for chronic liver diseases

Ochre Bioochre-bio.comin𝕏

Ochre Bio develops RNA therapeutics and drug discovery platforms targeting liver disease, combining proprietary human liver datasets with AI-driven causal prediction and human tissue validation models.

AI & Machine LearningBiotechHealthtechMedical DevicesLondon, GB

Quin Wills(Founder/CSO)in

BoardChinwe UkomaduElaine SullivanEliot ForsterJack Castle

Scioto Biosciences

Clinical-stage company developing bacterial therapeutics for GI and neurological diseases

BiotechIndianopolis, US

Mark Heiman(Executive Officer)Joseph Trebley(Executive Officer, Director)James Schulz(Executive Officer, Director)Kevin Meyer(Executive Officer)

Simergentsimergent.comin

Simergent develops medical device systems for regulated healthcare markets, with expertise in peritoneal dialysis and infusion pump technologies.

BiotechHealthtechMedical DevicesChicago, US

Steve J. Lindo(Co-founder & CEO)Rick Pendergraft(Co-founder & Chief Technology Officer)Dr. James Sloand(Chief Medical Officer)Michael J Rohleder(Manager)Rick J Pendergraft(Manager)Steve J Lindo(Manager and Chief Executive Officer)

Simergent

Building an automated peritoneal dialysis device for cheaper, safer, and smarter home-based dialysis

Frequently asked questions

What stage does Pathway Bioventures invest at?
Pathway Bioventures invests at the Pre-Seed, Seed, Series A stages.
What sectors does Pathway Bioventures focus on?
Pathway Bioventures focuses on Biotech, Healthtech, Medical Devices.
Where is Pathway Bioventures located?
Pathway Bioventures is headquartered in Chicago, US.

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