The Engine Ventures — Full Portfolio

Foundation Alloy engineers custom metal alloys and components using solid-state processing that avoids melting, enabling microstructures and contaminant control that conventional metallurgy cannot achieve.

Advanced ManufacturingDeep TechNew Materials

Jasper Lienhard(Cofounder)

Addis Energy develops technology that combines oil and gas engineering expertise with advanced research to access energy and resources from subsurface geology.

CleantechDeep TechEnergy

Rapid robotic synthesis of valuable peptides and protein structures that can't be manufactured with cells.

Amide is a peptide synthesis provider that manufactures hard-to-obtain peptides on demand, offering reliable linear synthesis up to 120 amino acids and large full-length proteins via ligation.

Advanced ManufacturingBiotechDeep Tech

Anthology develops designer and hybrid genomes by decoding genomic "language" to engineer microbes that convert feedstocks such as sugars, plastics, and agricultural waste into products like chemicals, materials, and food ingredients.

BiotechFoodTechNew Materials

Building scalable quantum computers with reduced complexity and cost to reach error correction at scale.

Cambridge, US

Bharath Kannan(Executive Officer)Simon Gustavsson(Director)

An MIT spinoff developing AI systems for logical reasoning and prototype development, focusing on semiconductor-based hardware with a goal to achieve tenfold productivity gains by 2030.

Axoft develops soft neural implants and brain-computer interface technology for research and clinical applications.

BiotechDeep TechMedical DevicesCambridge, US

Paul Le Floch(Executive Officer, Director)inRachel Sha(Director)Tianyang Ye(Director)

BoardChia An Lee(Director)Benjamin Pless(Director)

Bexorg is a biotech platform for CNS drug discovery built on a whole-brain perfusion model that allows manipulation and recording of cellular activity in intact human brains.

AI & Machine LearningBiotechDigital HealthMedical DevicesNew Haven, US

BoardZvonimir VrseljainNenad Sestan

Biobot pioneers wastewater epidemiology, monitoring pathogens and substances in sewage to provide real-time public health surveillance at the community level.

BiotechData & InfrastructureGovTechHealthtechBoston, US

Newsha Ghaeli(Cofounder & President)inMariana Matus(Founder)inMariana Guadalupe Matus Garcia(Executive Officer, Director)

BoardVivek Pattipati(Director)Andrew Perlman(Director)

Blue Energy develops scalable small modular reactor (SMR) technology to deliver nuclear power at scale.

CleantechClimate TechDeep TechEnergyHardwareWashington, US

JakeTomJacob Jurewicz(Executive Officer, Director)Thomas O'Neill(Executive Officer, Director)

BoardOrin Hoffman(Director)Michael Kearney(Director)

Boston Metal develops Molten Oxide Electrolysis (MOE), a platform technology for producing high-value and critical metals from inputs such as low-grade ores, mining waste, and industrial waste.

Advanced ManufacturingCleantechNew Materials

Tadeu Carneiro(CEO)in

The page describes Photonic Fabric, an optical interconnect technology platform for the scale-up interconnect market that enables high-bandwidth, power-efficient links for AI data center infrastructure.

AI & Machine LearningDeep TechSector AgnosticSemiconductorsSanta Clara, US

Preetinder Virk(Chief Operating Officer)David Lazovsky(President and Chief Executive Officer)Kelyn Brannon(Chief Financial Officer)Philip Winterbottom(Chief Technology Officer)Alexis Bjorlin(Director)

BoardLip-Bu Tan(Director)

Curing the world's toughest diseases by automating personalized medicine.

Cellineobio develops cell engineering and bioprocess technology platforms.

AI & Machine LearningBiotechDeep TechMedical DevicesCambridge, US

Nabiha Saklayen, PhD(Co-Founder & CEO)inMarinna Madrid, PhD(Co-Founder & Chief Product Officer)Nabiha Saklayen(Executive Officer, Director)Matthias Wagner(Executive Officer, Director)

BoardKatie Rae(Director)

Commonwealth Fusion Systems develops commercial fusion power plants using high-temperature superconducting magnet technology to provide grid-scale energy.

CleantechClimate TechDeep TechEnergyCambridge, US

Brandon Sorbom(Founder)Robert Mumgaard(Executive Officer, Director)Daniel Brunner(Executive Officer)Massimiliano Pieri(Director)Alan Eustace(Director)

BoardKatie Rae(Director)

Copernic develops catalysts for zero-carbon ammonia and e-fuels that are cost-competitive and compatible with existing industrial infrastructure.

CleantechClimate TechDeep TechEnergyCambridge, US

Jacob Ebenstein Grose(Executive Officer, Director)

BoardLindy Fishburne(Director)Michael Kearney(Director)Michael LoCascio(Director)

DG Matrix develops the Interport platform, a multi-port solid-state transformer solution that enables software-defined, flexible power distribution for AI data centers, commercial/industrial electrification, EV fleet charging, and utility grid environments.

AI & Machine LearningEnergyHardware

Droplet has developed a platform to collect and profile patient lymph fluid from routine surgical drain fluid, enabling a lymph-based liquid biopsy.

BiotechHealthtechMedical DevicesMelrose, US

Stanley Lapidus(Director)Theresa Tribble(Executive Officer, Director)Aadel Chaudhuri(Executive Officer, Director)Jose Zevallos(Director)

BoardAnn DeWitt(Director)

Startup cofounded by Emmanuel Kasseris.

Cheaper, sustainable electrolyzer solution enables hydrogen delivery to the world.

Protecting and restoring natural ecosystems, one plant cell at a time.

BiotechCambridge, US

Ashley Beckwith(Executive Officer, Director)

Foray Bioscience uses single plant cells and AI-powered software (Pando) to direct how plant matter forms, producing plant materials, molecules, and seeds without growing whole plants.

AgTechAI & Machine LearningBiotech

Ashley Beckwith(Founder & CEO)

Form Energy develops and manufactures iron-air batteries designed to store energy for up to 100 hours, targeting utility-scale grid reliability and multi-day energy storage.

Advanced ManufacturingCleantechEnergy

Mateo Jaramillo(Founder & CEO)inTed Wiley(Founder)inBilly Woodford(Founder)Yet-Ming Chiang(Founder)inMarco Ferrara(Founder)

Genomines uses biological systems to extract battery-grade nickel from low-grade soils, producing critical metals at lower cost and environmental impact than traditional mining.

BiotechCleantechNew Materials

Dali Rashid(CTO)

HPCwire is a news and media outlet covering high performance computing, supercomputing, AI, and related enterprise technology topics for industry professionals.

AI & Machine LearningEnterprise SoftwareMedia & Entertainment

Hyfé refines food waste to extract specialty ingredients and chemical compounds for use in food, beverage, personal care, nutraceutical, and biomanufactured products.

BiotechCircular EconomyFoodTechChicago, US

Michelle Ruiz(Executive Officer, Director)Andrea Schoen(Executive Officer)

Repurposing wastewater into low-cost feedstock to enable biomanufacturing at scale.

Ultra-efficient optical circuits to de-bottleneck data centers and telecom networks.

Enabling precision-genomic editing with single-stranded DNA technology.

Kano Therapeutics is a biotech company developing chemical biology platforms aimed at clinical and commercial therapeutic products.

BiotechCambridge, US

Floris Engelhardt(Executive Officer, Director)John Vroom(Director)

BoardAnn DeWitt(Director)

MIT spin-out offering a customizable multi-solution platform for discovery, development, and manufacturing of cell therapies using non-viral delivery technology.

BiotechCambridge, US

Cullen Buie(Director)Michael Chiu(Director, Executive Officer)Paulo Garcia(Executive Officer, Director, Promoter)

BoardPaxton Major(Director)Ann DeWitt(Director)Paul Wotton(Director)

Lilac Solutions develops direct lithium extraction technology using ceramic ion exchange media, enabling fast, clean, and affordable lithium production from brines for the electric vehicle and battery industries.

CleantechClimate TechEnergyNew MaterialsOakland, US

David Snydacker(President & Chief Technology Officer)inNicholas Goldberg(Chief Legal Officer of Issuer)Ian Pearce(Director)inDavid Gelinas(Chief Financial Officer of Issuer)inSamuel Romer(Director)Raef Sully(Chief Executive Officer of Issuer)in

Mantel Capture, Inc. appears to operate in process engineering and commissioning, with roles referencing boilers, licensing, and research; the page itself provides no explicit statement of the company's product or market.

CleantechClimate TechNew MaterialsCambridge, US

Cameron Halliday(Executive Officer, Director)Danielle Rapson(Executive Officer, Director)Danielle Colson(Cofounder)Sean Robertson(Director)

BoardHooisweng Ow(Director)Michael Kearney(Director)

Osmoses develops a membrane technology for purifying and separating gas molecules, aimed at making industrial gas separation processes more energy-efficient.

CleantechClimate TechDeep TechNew MaterialsBoston, US

Francesco Benedetti(Co-Founder & CEO)Katherine Mizrahi Rodriguez(Co-Founder & Chief Implementation Officer)Zachary P. Smith(Co-Founder / Associate Professor, MIT)

Oso Semiconductor develops power-efficient, high-performance beamforming chipsets for wireless systems using phased-array (electrically steered) antennas, based on ultra-low-loss beamforming IP.

Defense TechHardwareSemiconductors

Space-based solar power providing 24/7 clean energy

Covina, US

Andrew Cantino(Executive Officer, Director)Marc Berte(Executive Officer, Director)

BoardAnton Brevde(Director)

A materials breakthrough to eliminate the climate impact of cooling.

Pascal develops solid refrigerants for heating, ventilation, and air conditioning systems with zero global warming potential.

Advanced ManufacturingCleantechClimate Tech

Using molecular diagnostics to transform the patient experience and unlock novel therapies.

Predicta develops a molecular insights platform for blood cancer care that generates genomic and immune profiling from blood samples to guide treatment decisions and monitor disease evolution.

BiotechDigital HealthMedical DevicesCambridge, US

Universal access to geothermal energy through disruptive millimeter wave drilling technology.

Quaise Energy develops superhot geothermal drilling technology using millimeter-wave powered drilling to access deep geothermal energy sources at unprecedented depths and temperatures for large-scale clean power generation globally.

CleantechDeep TechEnergyHouston, US

Carlos Araque(Executive Officer, Director)Vinod Khosla(Director)William Restrepo(Director)Frohman Anderson(Director)Ali Azad(Director)

BoardColleen Calhoun(Director)

Marvell designs custom silicon and provides interconnect and network switch products for AI data center infrastructure, serving hyperscalers, enterprises, and telecom carriers.

AI & Machine LearningData & InfrastructureSemiconductors

Resonant Link Inc. developed wireless power technology and is no longer operating as an active business, now managing and licensing its patent portfolio for non-medical wireless power.

Deep TechEnergyHardwareMedical DevicesShelburne, US

Grayson Zulauf(Executive Officer, Director)Aaron Stein(Director)Orin Hoffman(Director)

BoardShilpi Kumar(Director)

Applying a fundamental mathematical insight to the problem of turbulence.

RISE Robotics develops RISE® Cylinder, a fluid-free electro-mechanical alternative to hydraulic cylinders for heavy equipment and machinery that uses belt technology to deliver hydraulic-like forces with significantly greater energy efficiency.

Advanced ManufacturingCleantechDeep TechHardwareRoboticsBoston, US

Arron Acosta(Co-Founder, VP of Business Development)Blake Sessions(Co-Founder & Chief Technology Officer)Toomas Sepp(Co-Founder & Chief Engineer)Kyle Dell'Aquila(Co-Founder & Head of Industrial Design & Customer Experience)Hiten Sonpal(Chief Executive Officer)

Seaspire develops safe and sustainable suncare and skincare products using Xanthochrome®, a proprietary class of biomolecules inspired by oceanic compounds.

BiotechConsumerDirect to ConsumerWellness & FitnessCambridge, US

Camille A. Martin(CEO and co-founder)Leila Deravi(Co-founder and scientific advisor)

EnergyCambridge, US

Gareth Ross(Executive Officer, Director)Curtis Belinguete(Director)

BoardPatrick Sarver(Director)Marc Tarpenning(Director)Michael Kearney(Director)

Sublime Systems develops an energy-saving, carbon-reducing process for manufacturing cement from previously inaccessible minerals.

CleantechClimate TechConstruction TechNew MaterialsBoston, US

Leah Ellis(Co-founder)Yet-Ming Chiang(Co-founder)in

Producer of zero-carbon cement for scalable, sustainable building materials.

Transforming logistics with a revolutionary electric truck design.

Optimizing the resources at the heart of every cloud computation.

Cambridge, US

Suraj Bramhavar(Director)Jeffery Chou(Executive Officer, Director)

Chemical manufacturing driven by light, enabling cheaper scalable on-site production.

Creating a fundamentally new sensor to improve automotive safety.

Terragia develops consolidated bioprocessing technology using engineered thermophilic bacteria to convert cellulosic biomass, such as crop residues and perennial crops, into ethanol, other biofuels, and co-products at costs competitive with petroleum.

BiotechCleantechEnergy

Lee Lynd(CTO & Co-Founder)

Terrestrial develops the Tacterra microarray patch platform to deliver a wide range of therapies, including GLP-1, through the skin using dissolvable tips—eliminating needles and refrigeration requirements.

BiotechDigital HealthMedical Devices

Rachel Sha(CEO)

Bringing new intelligence to industrial robots.

Terrestrial develops the Tacterra microarray patch platform, a dissolvable skin-patch technology for delivering therapies including GLP-1 without injection.

BiotechHealthtechMedical Devices

Rachel Sha(CEO)

VEIR manufactures low- and medium-voltage superconducting systems that deliver electricity for high-performance AI data centers.

AI & Machine LearningDeep TechEnergyHardwareWoburn, US

Tim Heidel(CEO & Co-Founder)inDoug Stewart(Director)

BoardAdam Wallen(Executive Officer, Director)

Cambridge, US

Brent Keller(Executive Officer, Director)Shreya Dave(Executive Officer, Director)

BoardKatie Rae(Director)Arunas Chesonis(Director)

Worcester Business Journal (WBJ) is a regional business news publication serving Central Massachusetts, delivering local business news, market data, and features such as its Book of Lists and Giving Guide.

Media & Entertainment

WoHo develops systems to change how buildings are designed and constructed, aligning the efforts of cities, developers, contractors, and designers to improve quality and reduce waste and inefficiency.

Construction TechPropTech

Antón García-Abril(Co-Founder & CEO)Débora Mesa(Co-Founder, President & CDO)Borja Soriano(Chief Operating Officer)Javier Cuesta(Chief Technology Officer)Eduardo Cadorniga(Chief Financial Officer)