The Engine Ventures — Full Portfolio

ISEE AI builds fully autonomous yard trucks for industrial supply chain and logistics operations, combining an AI platform with software and hardware engineering to automate yard operations.

AI & Machine LearningLogistics & Supply ChainRoboticsCambridge, US

Yibiao Zhao(Executive Officer, Director)inLe Yu(Director)

Board seatRSReed Sturtevant· per SEC Form D

Co-investorsBOBoston Seed CapitalENEniac VenturesHYHyperplane Venture CapitalMAMaersk GrowthSASafar PartnersSASamsung Next+1 more

STRM.BIO develops technology to deliver gene therapies, aiming to improve how these treatments reach patients.

BiotechDeep TechHealthtechLongevityMedical Devices

MLMichael Luther(CEO)in

Co-investorsASAscension VenturesBRBreakout LabsBRBreakout VenturesDEDelos CapitalNYNYBC VenturesBOBoehringer Ingelheim Venture Fund+1 more

Abselion develops measurement tools and a platform combining hardware, purpose-built assay formats, and software for biological measurements such as protein quantification.

BiotechDeep TechHardwareMedical DevicesCambridge, GB

DRDr Ruizhi Wang(CEO)

Co-investorsCACambridge Angels groupM M VenturesBUBusiness Growth FundR4R42 GroupUNUniversity of Cambridge EnterpriseUNUntitled Ventures

Addis Energy develops technology that combines oil and gas engineering expertise with advanced research to access energy and resources from subsurface geology.

CleantechDeep TechEnergySomerville, US

Michael Alexander(Founder)inCharlie Mitchell, P.E.(Founder)inIwnetim Iwnetu Abate(Director)Oliver Charles Mitchell(Director)

BoardLMLaurie Menoud(Director)inMKMichael Kearney(Director)in

Co-investorsATAt One VenturesBLBlindspot Ventures Management CoPIPillar VCVOVoyager PartnersFOFounders FundKHKhosla Ventures

Anthology develops designer and hybrid genomes by decoding genomic "language" to engineer microbes that convert feedstocks such as sugars, plastics, and agricultural waste into products like chemicals, materials, and food ingredients.

BiotechFoodTechNew Materials

Dr. Tzu-Chieh 'Zijay' Tang(CTO & Co-Founder)

Co-investorsALAlumni VenturesCOCollaborative FundJUJuniperTATaihill VentureTHThe E14 Fund

Apeiron Labs develops autonomous underwater vehicles and ocean technology for marine applications.

Climate TechDeep TechIoTRoboticsCambridge, US

RPRavi Pappu(CEO / Board Member)in

BoardSKSanjeev Krishnan(Director)Jonathan Rosen(Director)David Douglas(Director)KTKyle Teamey(Director)inMark Abbott(Director)

Co-investorsBABay Bridge Ventures ClimateCOCoalitionS2S2G InvestmentsTFTFX CapitalBRBreakthrough Energy VenturesRARA Capital

Marvell designs custom silicon and provides interconnect and network switch products for AI data center infrastructure, serving hyperscalers, enterprises, and telecom carriers.

AI & Machine LearningCloud ComputingData & InfrastructureSemiconductorsSan Jose, US

Phil Delansay(Co-Founder; President & CEO (2004-2009), later SVP Business Development)RFRamin Farjadrad(Co-Founder; Chief Architect (2005-2012), later VP Technology Development)inRamin Shirani(Senior Vice President, Engineering; Director)Linda Reddick(Senior Vice President, Finance (previously Chief Financial Officer, Sept. 2009-Jan. 2016))Phillippe Delansay(Executive Officer)Mark Voll(Chief Financial Officer)

Co-investorsALAllegisCyber CapitalAUAugust CapitalCECelesta CapitalCICisco InvestmentsGLGLOBALFOUNDRIESICICCP Venture Partners+11 more

Building scalable quantum computers with reduced complexity and cost to reach error correction at scale.

Cambridge, US

BKBharath Kannan(Executive Officer)inSGSimon Gustavsson(Director)in

Co-investorsBLBlindspot Ventures Management CoCHChalmers Ventures ABGLGlasswing VenturesMAMassVenturesNENeotribe VenturesTHThe E14 Fund+2 more

AtmosZero builds modular electrified heat pump boilers that draw heat from ambient air to produce emissions-free industrial steam as a drop-in replacement for fuel-burning boilers.

CleantechClimate TechEnergy

ASAddison Stark(Founder)in

Co-investorsAEAENUCOConstellation Technology VenturesENEnergy Impact PartnersMIMitsubishi Heavy IndustriesSTStarlight VenturesVXVXI Capital

Axiomatic AI makes Lemma, an AI co-explorer for scientific and engineering work that helps users validate, derive, and analyze equations and reasoning across mathematics, physics, and engineering with reproducible Python-based modeling.

AI & Machine LearningDeep TechDeveloper Tools

Co-investorsPRPropagator VenturesTWTwo Small Fish VenturesKLKleiner PerkinsG G Vision Capital

Axoft is developing soft, tissue-mimicking neural implants and supporting bidirectional electronics that record and stimulate brain activity through a minimally-invasive burr-hole procedure.

AI & Machine LearningDeep TechMedical DevicesCambridge, US

PLPaul Le Floch(Executive Officer, Director)inTYTianyang Ye(Director)inRSRachel Sha(Director)in

BoardChia An Lee(Director)Benjamin Pless(Director)

Co-investorsALAlumni VenturesAMAmino CapitalARArcherman CapitalBLBlindspot Ventures Management CoCACastor VenturesCRCreative Destruction Lab (CDL)+4 more

Bexorg is a biotech platform for CNS drug discovery built on a whole-brain perfusion model that allows manipulation and recording of cellular activity in intact human brains.

AI & Machine LearningBiotechDigital HealthMedical DevicesNew Haven, US

Zvonimir Vrselja Nenad Sestan(Founder)

BoardZVZvonimir Vrselja(Founder)inNSNenad Sestan(Founder)

Co-investorsAMAmplify PartnersCOConnecticut InnovationsAMAmplify Partners CVE1E1 Ventures

Biobot pioneers wastewater epidemiology, monitoring pathogens and substances in sewage to provide real-time public health surveillance at the community level.

BiotechData & InfrastructureGovTechHealthtechBoston, US

NGNewsha Ghaeli(Founder)inMMMariana Matus(Founder)inMariana Guadalupe Matus Garcia(Executive Officer, Director)

BoardVPVivek Pattipati(Director)inAPAndrew Perlman(Director)in

Co-investorsAMAmerican Family Insurance Institute for Corporate and Social ImpactBLBlindspot Ventures Management CoDCDCVC (Data Collective)DEDesignXDODorm RoomHOHomebrew+22 more

Blue Energy develops scalable small modular reactor (SMR) technology to deliver nuclear power at scale.

CleantechClimate TechDeep TechEnergyHardwareWashington, US

JakeTomJacob Jurewicz(Executive Officer, Director)Thomas O'Neill(Executive Officer, Director)

BoardOHOrin Hoffman(Director)MKMichael Kearney(Director)in

Co-investorsATAt One VenturesANAngular VenturesNENeutron Power VenturesNUNucleation CapitalTATamarack GlobalFOFounders Fund+4 more

Blueshift creates AI-driven solutions for customer engagement and marketing intelligence that enable consumer marketers to execute data-driven campaigns across multiple channels.

AI & Machine LearningMarketing TechSaaSSan Francisco, US

Subramanyam Mallela(Executive Officer, Director)MSMehul Shah(Founder)inVCVijay Chittoor(Founder)inManyam Mallela(Founder)

BoardJBJishnu Bhattacharjee(Director)inAnshu Sharma(Director)

Co-investorsAVAvatar Growth Capital PartnersCOConductive VenturesGRGreat Oaks Venture CapitalMIMilliways VenturesNENew Enterprise Associates (NEA)R1R136 Ventures+5 more

Boston Metal develops Molten Oxide Electrolysis (MOE), an electrified process for producing steel and other metals from a range of oxide feedstocks without direct emissions.

Advanced ManufacturingCleantechClimate TechNew MaterialsWoburn, US

DSDonald Sadoway(Founder)inAAAntoine Allanore(Founder)TCTadeu Carneiro(CEO)inJames Yurko(Founder)

Co-investorsBRBreakthrough Energy VenturesCLClimate InvestmentPRPrelude VenturesINInternational Finance CorporationBMBMW i VenturesENEnergy Impact Partners+8 more

Butlr makes anonymous thermal sensors that measure occupancy and space utilization across offices, buildings, campuses, stores, and labs without cameras, badges, or Wi-Fi tracking.

AI & Machine LearningDigital HealthHardwareHealthtechIoTPropTechSan Francisco, US

HDHonghao Deng(Founder)inJZJiani Zeng(Founder)inHonghao Deng Jiani Zeng(Founder)

BoardRaymond Stuart Stata(Director)SLSeth Levine(Director)inNPNaimish Patel(Director)in

Co-investors1F1Flourish Capital50500 GlobalFOFounder CollectiveFOFoundryGSGS FuturesHDHDS Capital+17 more

Hyperion Biosystems builds diagnostic devices that use computer vision and physics-based algorithms to improve the sensitivity and specificity of point-of-care and at-home tests.

AI & Machine LearningHealthtechMedical Devices

Co-investorsNENewlin Investment Company LLCSASafar PartnersBOBoston Millennia PartnersBRBreakout LabsCRCranberry CapitalPRPropel Venture Partners

The page describes Photonic Fabric, an optical interconnect technology platform for the scale-up interconnect market that enables high-bandwidth, power-efficient links for AI data center infrastructure.

AI & Machine LearningDeep TechSector AgnosticSemiconductorsSanta Clara, US

Preetinder Virk(Chief Operating Officer)DLDavid Lazovsky(Founder)inKelyn Brannon(Chief Financial Officer)Philip Winterbottom(Chief Technology Officer)inDave Lazovsky(Founder)Preet Virk(Founder)

Co-investorsFIFitz Gate VenturesIAIAG Capital PartnersIMimec.xpandKOKoch Disruptive TechnologiesM M VenturesSASamsung Catalyst Fund+11 more

Cellineobio develops cell engineering and bioprocess technology platforms.

AI & Machine LearningBiotechDeep TechMedical DevicesCambridge, US

NSNabiha Saklayen, PhD(Co-Founder & CEO)inMMMarinna Madrid, PhD(Co-Founder & Chief Product Officer)inNSNabiha Saklayen(Founder)inMWMatthias Wagner(Founder)inMarinna Madrid(Founder)Stan Wang(Founder)

Co-investors8V8VCCOCota CapitalFEFelicis VenturesHAHAWKTAILKHKhosla VenturesHUHumboldt+1 more

Commonwealth Fusion Systems develops commercial fusion power plants using high-temperature superconducting magnet technology to provide grid-scale energy.

CleantechClimate TechDeep TechEnergyCambridge, US

BSBrandon Sorbom(Founder)inRobert Mumgaard(Executive Officer, Director)inDBDaniel Brunner(Executive Officer)inBMBob Mumgaard(Founder)inDan Brunner(Founder)Dennis Whyte(Founder)

Co-investorsADAdvection Growth CapitalARArmada Investment AGBABay Bridge Ventures ClimateBEBeni Venture CapitalBRBrainstorm VenturesBRBreakthrough Energy Ventures+45 more

Concerto Bio generates large-scale ecological datasets on microbial communities and uses them to develop microbe-based consumer health products for applications such as skincare, chronic disease, and nutrition.

AI & Machine LearningBiotechDeep TechCambridge, US

JKJared Kehe(Executive Officer, Director)inCACheri Ackerman(Executive Officer, Director)inBCBernardo Cervantes(Executive Officer, Director)inVSVera Schroeder(Director)in

BoardSLSarah Luppino(Director)in

Co-investorsALAlumni VenturesEXExcelestar VenturesGOGolden SeedsHOHorizons VenturesISISVM M Ventures+4 more

Copernic develops catalysts for zero-carbon ammonia and e-fuels that are cost-competitive and compatible with existing industrial infrastructure.

CleantechClimate TechDeep TechEnergyCambridge, US

Aruna Ramkrishnan(Founder)inJacob Ebenstein Grose(Executive Officer, Director)

BoardLFLindy Fishburne(Director)inMKMichael Kearney(Director)inMichael LoCascio(Director)

Co-investorsBRBreakout VenturesFUFuture VenturesINInnospark VenturesJUJuniperNENew Climate Ventures

DBOS provides a durable workflow platform with observability and management tooling, letting developers view, cancel, resume, fork, and export application workflows through its Conductor console.

AI & Machine LearningCloud ComputingData & InfrastructureDeveloper Tools

PKPeter Kraft(Founder)inQLQian Li, PhD(Founder)inMike Stonebraker(Co-founder)

Co-investorsCOConstruct CapitalSISINEWAVE VENTURESGUGutbrain Ventures

DG Matrix builds the Interport platform, a multi-port solid-state transformer (SST) system for software-defined power distribution and electrification.

CleantechEnergyHardwareCary, US

HIHaroon Inam(Executive Officer, Director)in

BoardVVVlatko Vlatkovic(Director)

Co-investorsATat HulaCECerberus VenturesCLClean Energy VenturesINInnova Capital Partners, LLCTETech Square VenturesTHThird Derivative

Droplet Biosciences develops cancer diagnostics with a focus on liquid biopsy and precision oncology.

BiotechDigital HealthHealthtechMedical DevicesMelrose, US

HTHaluk Tezcan(Chief Medical Officer)inSLStanley Lapidus(Director)inTheresa Tribble(Executive Officer, Director)Aadel Chaudhuri(Executive Officer, Director)Jose Zevallos(Director)

BoardADAnn DeWitt(Director)in

Co-investorsIDIdeashipSASafar Partners

Startup cofounded by Emmanuel Kasseris.

Co-investorsGOGOOSE CapitalMAMassVenturesVEVectors AngelVXVX Ventures

Encora Therapeutics makes the Encora X1, an FDA-cleared, prescription wrist-worn device that uses mechanical neurostimulation to relieve hand tremors in adults with essential tremor.

HardwareHealthtechMedical Devices

DCDaniel Carballo(Cofounder)inADAllison Davanzo(Cofounder)KPKyle Pina(Cofounder)in

Co-investorsGOGood Growth CapitalINInnospark VenturesSASafar PartnersSBSBXi

Evoloh operates high-throughput factories that manufacture electrolyzer stacks, sold as its Nautilus stack module to EPCs and project developers building hydrogen plants.

Advanced ManufacturingCleantechEnergy

Jimmy Rojas(Founder)

Co-investorsBABaruch Future VenturesCOCollaborative FundJUJuniperSASafar PartnersTHThird SphereGSGS Futures

Finwave Semiconductor develops GaN-on-Silicon RF technology and devices, including E-mode GaN power amplifiers and high-power broadband RF switches for radio front-end applications.

Deep TechHardwareSemiconductors

Tomas Palacios(Co-founder)in

Co-investorsALAlumni VenturesCACastor VenturesCICitta CapitalFIFine Structures VenturesFOFoothill VenturesINIn-Q-Tel+5 more

Foray Bioscience uses single plant cells and AI-powered software (Pando) to direct how plant matter forms, producing plant materials, molecules, and seeds without growing whole plants.

AgTechAI & Machine LearningBiotechCambridge, US

ABAshley Beckwith(Founder & CEO)in

Co-investorsCOCollaborative FundMIMilemark Capital PartnersSEService Provider CapitalREReGen VenturesTETet Ventures

Form Energy develops and manufactures low-cost, multi-day iron-air battery systems for long-duration energy storage on the electric grid, serving utilities and project developers primarily in the United States.

Advanced ManufacturingCleantechEnergyHardware

MJMateo Jaramillo(Founder)inTWTed Wiley(Founder)inYCYet-Ming Chiang(Founder)inMFMarco Ferrara(Founder)inWWWilliam Woodford(Founder)in

Co-investors202045 VenturesBLBlindspot Ventures Management CoBRBreakthrough Energy VenturesCACarbonCOCoatue ManagementCOCongruent Ventures+12 more

Foundational Alloy develops engineering alloys through a solid-state process called MetalsFIRST, in which metal is produced without melting to create microstructures unreachable by conventional metallurgy while controlling oxygen and contaminants.

Advanced ManufacturingDeep TechNew Materials

Jasper Lienhard(Founder)Jake(Co-founder (company strategy, operations, financing, commercialization))Chris Schuh(Founder)Jake Guglin(Founder)Tim Rupert(Founder)

Co-investorsALAlumni VenturesAMAmerica's Frontier FundBABasecamp FundCACastor VenturesELEl Cap EquityMAMaterial Impact+6 more

Alex Gu(Founder)Zen Koh(Founder)

Co-investorsSOSoftBank Vision FundGEGeneral CatalystIDIDG CapitalINInnospark VenturesTATau Ventures

Genomines uses biological systems to extract battery-grade nickel from low-grade soils, producing critical metals at lower cost and environmental impact than traditional mining.

BiotechCleantechEnergyNew MaterialsParis, FR

FKFabien Koutchekian(Founder)inDRDali Rashid(Founder)inDr. Dali Rashid(Founder)

Co-investorsCACarbonDEDeepTech & Climate FondsENEntrepreneur FirstFOForbionHEHEC Paris IncubatorLOLowercarbon Capital+7 more

Google Quantum AI develops quantum computing hardware and algorithms, including its Willow quantum processor, with a focus on building a large-scale, error-corrected quantum computer.

Deep TechHardwareQuantum Computing

Hartmut Neven(Founder)

Harton Therapeutics offers a GMP-ready platform for advanced 3D cell manufacturing, using a perfusion-based single-use cartridge system with automated process control to produce human cells at scale.

Advanced ManufacturingBiotechMedical Devices

Co-investorsDEDecheng Capital

Hyfé operates a refining process that extracts specialty ingredients and chemical building blocks from food-processing waste and biomass.

Circular EconomyFoodTechNew MaterialsChicago, US

MRMichelle Ruiz(Executive Officer, Director)inAndrea Schoen(Executive Officer)

Co-investorsOVOverwater Ventures LlcSYSynthesis CapitalCHChemistryCRCraft VenturesPAPace Capital

HyperLight develops thin-film lithium niobate (TFLN) photonic integrated circuits for high-bandwidth, energy-efficient optical applications in data centers, telecommunications, quantum computing, and AI systems.

AI & Machine LearningDeep TechHardwareSemiconductorsCambridge, US

Co-investorsFOFoothill VenturesXOXora

HyperSpectral develops a spectral sensing and AI layer for Physical AI that interprets matter through spectral data, molecular identification, and AI architecture.

AI & Machine LearningDeep TechDefense TechHardwareAlexandria, US

Matthew Theurer(Executive Officer, Director)LSLauren Stack(Executive Officer, Director)inVincent Lubsey(Executive Officer)

BoardJLJuan Lopez(Director)inWPWilliam Porteous(Director)in

Co-investorsKIKibo VenturesRRRRE VenturesANAngelini VenturesGLGlade Brook Capital PartnersHEHeal CapitalLILifeX Ventures+1 more

Kano Therapeutics develops circular single-stranded DNA (cssDNA) as a genetic payload for gene-editing and other DNA-based therapies, offering an alternative to viral vectors and double-stranded DNA.

BiotechDeep TechCambridge, US

Floris Engelhardt(Executive Officer, Director)John Vroom(Director)

BoardADAnn DeWitt(Director)in

Co-investorsFIFifty YearsLALaunchpad Venture GroupMEMetaplanetVSVsquared VenturesZAZAKA VC

Kytopen develops non-viral gene delivery technology called Flowfect that combines fluid flow with electric fields to deliver payloads such as mRNA, DNA, and CRISPR Cas9 RNP into cells for high-throughput transfection.

BiotechDeep TechHardwareCambridge, US

CBCullen Buie(Founder; Board Observer)inPGPaulo Garcia(Founder)inMCMichael Chiu(Chief Executive Officer)in

BoardPMPaxton Major(Director)inADAnn DeWitt(Director)inPaul Wotton(Director)

Co-investorsBABantam GroupHOHorizons VenturesMAMassVenturesSESelvedge VentureTBTBD AngelsTETelegraph Hill Partners+2 more

Lilac Solutions develops direct lithium extraction technology using ceramic ion exchange media, enabling fast, clean, and affordable lithium production from brines for the electric vehicle and battery industries.

CleantechClimate TechEnergyNew MaterialsOakland, US

DSDavid Snydacker(Founder)inNicholas Goldberg(Chief Legal Officer of Issuer)DGDavid Gelinas(Chief Financial Officer of Issuer)inRSRaef Sully(Chief Executive Officer of Issuer)inDave Snydacker(Founder)

BoardCDClay Dumas(Director)in

Co-investorsBRBreakthrough Energy VenturesLOLowercarbon CapitalAZAzolla VenturesBEBerkeley Angel NetworkBMBMW i VenturesE8E8 Angels+10 more

Martin Bazant(Founder)Mo Alkhadra(Founder)Mohammad Alkhadra(Founder)

Co-investorsCLClean Energy VenturesLOLowercarbon Capital

MacroCycle uses a proprietary chemical process called SolvoGenesis, based on solvent systems and macrocyclic chemistry, to convert textile waste into pure polyester resin at low cost.

Circular EconomyCleantechNew MaterialsCambridge, US

Stwart Peña Feliz(Executive Officer, Director)inJRJan-Georg Rosenboom(Executive Officer, Director)in

BoardCatia Cesari(Director)TFTemple Fennell(Director)in

Co-investorsCICircular Innovation FundCOCollaborative FundNENeotribe VenturesVOVolta CircleCLClean Energy VentureCLClean Energy Ventures+2 more

Mantel Capture, Inc. appears to operate in process engineering and commissioning, with roles referencing boilers, licensing, and research; the page itself provides no explicit statement of the company's product or market.

CleantechClimate TechNew MaterialsCambridge, US

CHCameron Halliday(Founder)inDRDanielle Rapson(Founder)inDCDanielle Colson(Cofounder)inSRSean Robertson(Founder)inHoosiweng Ow(Director)

BoardHooisweng Ow(Director)

Co-investorsALAlumni VenturesAOAOKI LABSENEni NextNENew Climate VenturesTHThird DerivativeARArosa Ventures+9 more

Matrisome Bio is an oncology biotech developing therapies based on extracellular matrix (ECM) biology, using a protein engineering platform to target the tumor microenvironment.

BiotechDeep TechHealthtech

NJNoor Jailkhani(Chief Executive Officer, Co-Founder & President)inRHRichard Hynes(Co-Founder / Professor, MIT & HHMI)SBSangeeta Bhatia(Co-Founder / Professor, MIT & HHMI)inMGMonica Gostissa(Chief Science Officer)inETEdward Tad Stewart(Chief Business Officer)in

Co-investorsBOBold Capital Partners

MAV Unlimited develops volumetric 3D printing technology that manufactures objects in minutes rather than hours by printing the entire object simultaneously instead of layer-by-layer.

Advanced ManufacturingDeep TechHardwarePortland, US

Robert Shepherd(Co-founder)Thomas Wallin(Director)Aaron Pempel(Executive Officer, Director)

Co-investorsDEDeep FuturePOPortland Seed Fund

Merida is a biotherapeutics company developing a new class of drugs designed to selectively and durably eliminate the pathogenic antibodies that drive autoimmune and allergic diseases.

BiotechHealthtech

Pierre Bruhns(Co-founder; Director of Research, Pasteur Institute)Mark Shlomchik(Co-founder; Professor of Immunology, University of Pittsburgh)MNMichael Naill(Senior Vice President, Process and Product Development)in

Co-investorsBABain Capital Life SciencesTHThird Rock VenturesGVGV (Google Ventures)BIBiotechnology Value Fund

Mori makes a silk protein-based protective coating that extends the shelf life of fresh and packaged foods.

Co-investorsACAcre Venture PartnersBLBlindspot Ventures Management CoBLBluestein VenturesCOCollaborative FundDNDns CapitalTOToba Capital+1 more

Multiply Labs builds robotic systems that automate biologics manufacturing for pharmaceutical companies.

Advanced ManufacturingBiotechDeep TechRoboticsSan Francisco, US

FPFred Parietti(Founder)inAMAlice Melocchi(Founder)in

BoardSRShaun Rodriguez(Director)inMichael Doherty(Director)

Co-investorsFIFifty YearsGAGarage CapitalJUJude GomilaLILingottoP1P101 VenturesSTStrange Ventures+16 more

Northwood provides end-to-end ground infrastructure for space missions, from concept through deployment to live data delivery.

Deep TechHardwareSaaSSpace Tech

SLShaurya Luthra(Founder)inBridgit Mendler(Founder)Griffin Cleverly(Founder)

Co-investorsALAlpine Space VenturesALAlso CapitalALAlumni VenturesANAndreessen HorowitzAUAurelia FoundryBABalerion Space Ventures+13 more

Notch is an agentic AI operations platform that automates customer-facing, internal, and back-office workflows for regulated industries such as insurance, finance, and telecom.

AI & Machine LearningEnterprise SoftwareSaaSNew York City, US

EJElool Jacoby(Founder)inRafael Broshi(Founder)Yuval Peled(Founder)

Co-investorsJIJibe VenturesLILitquidity VenturesGOGolden VenturesHEHeadlineILIlluminate FinancialLILightspeed Venture Partners+2 more

OpenStar develops compact fusion energy technology using a levitated dipole approach and high-temperature superconducting systems, working toward commercial fusion.

CleantechDeep TechEnergyWellington, NZ

RMRatu Mataira(Founder)inThomas Berry(Co-founder & Chief Product Officer)inDGDarren Garnier(Chief Science Officer)inRod Badcock(Chief Technology Officer)inNFNicole Ferguson(VP - Finance)inBen Taylor-Bryant(VP - Investor Relations)in

Co-investorsBLBlackbird VenturesICIcehouse VenturesNZNZ Growth Capital PartnersOUOutset VenturesRARadar Ventures

Osmoses develops a membrane technology for purifying and separating gas molecules, aimed at making industrial gas separation processes more energy-efficient.

CleantechClimate TechDeep TechNew MaterialsBoston, US

Francesco Benedetti(Co-Founder & CEO)inKatherine Mizrahi Rodriguez(Co-Founder & Chief Implementation Officer)inZPZachary P. Smith(Co-Founder / Associate Professor, MIT)

Co-investorsBLBlindspot Ventures Management CoCOCollaborative FundFIFine Structures VenturesMAMassVenturesNENew Climate VenturesOROrbia Ventures

Francesco Maria Benedetti(Founder)Holden Lai(Founder)Katherine Mizrahi Rodriguez(Founder)Zachary Smith(Founder)

Co-investorsBLBlindspot Ventures Management CoENEnergy Capital Ventures

Oso Semiconductor develops power-efficient, high-performance beamforming chipsets for wireless systems using phased-array (electrically steered) antennas, based on ultra-low-loss beamforming IP.

Defense TechHardwareSemiconductors

Co-investorsCOCollaborative FundENEntrada VenturesFIFitz Gate Ventures

Overview Energy develops space-based solar power systems that beam energy from space to Earth, drawing on expertise in aerospace, energy systems, and manufacturing.

CleantechEnergySpace TechCovina, US

AAAbdullah Al-Shakarchi(Co-CEO)inDPDr. Paul JaffeinDPDr. Patrick MockinHMHannah MacKayinSKSagi KfirinAndrew Cantino(Co-Founder of Overview Energy)in

Co-investorsANAngel Collective Opportunity FundAUAurelia FoundryCOColle Capital PartnersDADangerous VenturesEAEarthrise VenturesJEJetstream+4 more

Ivo Crnkovic-Rubsamen(Founder)Matthew Downey(Founder)

Co-investorsANAntlerBLBlindspot Ventures Management CoSOSouth Park CommonsUNUnion Square Ventures (USV)

Pascal is developing solid refrigerants for the heating, ventilation, and air conditioning (HVAC) industry that operate in the same temperature and pressure ranges as gaseous refrigerants but with zero global warming potential.

CleantechClimate TechNew MaterialsCambridge, US

ASAdam SlavneyinJSJinyoung SeoinJMJarad Mason

Co-investorsBLBlindspot Ventures Management CoCOCollaborative FundLBLB Investment

Pearl Bio develops technologies for genome engineering, ribosome engineering, and biomanufacturing to enable production of novel proteins, chemicals, and materials for biotechnology and medicine.

BiotechDeep TechNew MaterialsStamford, US

FIFarren Isaacs(Founder)MJMichael Jewett(Founder)inACAmy Cayne Schwartz(Founder)inMerton Gollaher(Executive Officer)

BoardGCGeorge Church(Science Advisor)JRJesse Rinehart(Science Advisor)

Co-investorsKHKhosla Ventures

Predicta Biosciences operates a molecular insights platform for blood cancer care, using whole genome sequencing of intact circulating tumor cells from a single blood sample combined with single-cell immune profiling to characterize disease biology and immune response.

BiotechDigital HealthMedical DevicesCambridge, US

IGIrene Ghobrial(Co-founder)inKAKenneth Anderson(Co-founder)GGGad Getz(Co-founder)RSRomanos Sklavenitis-Pistofidis(Co-founder)KFKeith Flaherty(Co-founder)Brian McKernan(CEO)in

Co-investorsILIllumina Ventures

Quaise Energy develops ultra-deep geothermal drilling using gyrotron-powered millimeter-wave technology to reach depths up to 20 km and temperatures up to 500°C, aiming to build superhot geothermal power plants.

CleantechDeep TechEnergyHouston, US

MHMatt Houde(Founder)inCACarlos Araque(Founder)inAMAaron Mandell(Founder)inPaul Woskov(Founder)

BoardCCColleen Calhoun(Director)inVinod Khosla(Director)

Co-investorsCOCollaborative FundFIFine Structures VenturesHEHelium-3 VenturesPRPrelude VenturesTETechEnergy VenturesXPXplorer Capital+6 more

Quantum Machines builds Hybrid Control systems that integrate quantum control units with classical compute, including the Pulse Processing Unit (PPU) and a development platform based on the QUA language.

Deep TechHardwareQuantum ComputingClaymont, US

Nissim Ofek(Founder)Itamar Sivan(Founder)Yonatan Cohen(Founder)

Co-investorsALAlumni VenturesBABattery VenturesINIntel CapitalMAMaor InvestmentsMEMeron CapitalOUOurCrowd+6 more

Radix Labs develops software systems that manage operations and workflows in biological research laboratories.

BiotechHealthtechMedical DevicesBoston, US

DSDhasharath Shrivathsa(Founder)inIPIan Paul(Founder)in

Co-investorsY Y CombinatorBLBlindspot Ventures Management CoFIfirstminute capitalLILiquid VenturesPRProtocol LabsSOSound Ventures

Resonant Link Inc. developed wireless power technology and is no longer operating as an active business, now managing and licensing its patent portfolio for non-medical wireless power.

Deep TechEnergyHardwareMedical DevicesShelburne, US

GZGrayson Zulauf(Chief Executive Officer, co-founder)PAPhyo Aung Kyaw, PhD(Chief Science Officer, co-founder)Charles Sullivan(Co-founder)inAaron Stein(Chief Technology Officer, co-founder)in

BoardOrin Hoffman(Director)SKShilpi Kumar(Director)in

Co-investorsFRFreshTracks CapitalISISVWIWIND VenturesIMIMPACT SCIENCE VENTURESSCScout VenturesTHThird Sphere

Applying a fundamental mathematical insight to the problem of turbulence.

Justin Beroz(Founder)

Co-investorsCOCollaborative FundDADay One VenturesTHThird Sphere

RISE Robotics develops RISE® Cylinder, a fluid-free electro-mechanical alternative to hydraulic cylinders for heavy equipment and machinery that uses belt technology to deliver hydraulic-like forces with significantly greater energy efficiency.

Advanced ManufacturingCleantechDeep TechHardwareRoboticsBoston, US

AAArron Acosta(Co-Founder, VP of Business Development)inBSBlake Sessions(Co-Founder & Chief Technology Officer)inTSToomas Sepp(Co-Founder & Chief Engineer)inKDKyle Dell'Aquila(Co-Founder & Head of Industrial Design & Customer Experience)inHSHiten Sonpal(Chief Executive Officer)in

Co-investorsD3D3VCDEDecisive PointTETechstars

Robigo develops engineered microbial crop protection products for growers, including a biological solution targeting Sudden Death Syndrome in soybean.

AgTechBiotechFoodTech

AWAndee Wallace, PhD(Founder)in

Co-investorsCOCongruent VenturesENEndeavor8FIFirst Star VenturesGOGood Growth CapitalSUSUPPLY CHANGE CAPITALSVSVG Ventures | THRIVE+4 more

Rock Zero is a technology company with chemistry, materials, and process engineering teams working on chemical and materials science-based technology.

CleantechDeep TechEnergyNew MaterialsCambridge, US

CHCamden Hunt(Co-Founder & CEO)inBMBenjamin Mowbray(Co-Founder & CTO)inYCYet-Ming Chiang(Co-Founder & CIO)in

Co-investorsAZAzolla VenturesBLBlindspot Ventures Management CoTOToyota Ventures

Seaspire develops safe and sustainable suncare and skincare products using Xanthochrome®, a proprietary class of biomolecules inspired by oceanic compounds.

Advanced ManufacturingBiotechConsumerDirect to ConsumerWellness & FitnessCambridge, US

LDLeila Deravi(Co-founder and scientific advisor)inCMCamille Martin, PhD(Founder)in

Co-investorsALAlumni VenturesHUHuntington Angels NetworkMAMassVenturesSASafar PartnersTETechstars

SiTration develops silicon-based electro-extraction (SEE) and nano-filtration (SNF) technologies that recover metals and critical minerals from mining waste, leachate, and recycled material using electricity and no added chemicals.

CleantechDeep TechNew MaterialsCambridge, US

BSBrendan Smith(Co-founder & CEO)inJeffrey Grossman(Co-founder & Chief Scientist)

BoardJBJacob Bro(Director)inMNMatthew Nordan(Director)in

Co-investorsAZAzolla VenturesCACarbonTHThe E14 FundWOWorking Capital FundBHBHP VenturesEXExtantia Capital+1 more

Sora Fuel produces sustainable aviation fuel (SAF) and diesel using a proprietary closed-loop direct air capture and conversion process that draws carbon from air rather than biomass or industrial feedstocks.

CleantechClimate TechEnergyCambridge, US

Curtis Berlinguette(Founder)inGareth Ross(Founder)inCurtis Belinguete(Director)

BoardPatrick Sarver(Founder)inMTMarc Tarpenning(Director)inMKMichael Kearney(Director)in

Co-investorsINInnovation UBCINInspired CapitalLELeitmotifSPSpero VenturesWIWireframe Ventures

Sublime Systems develops an energy-saving, carbon-reducing process for manufacturing cement from previously inaccessible minerals.

CleantechClimate TechConstruction TechNew MaterialsBoston, US

LELeah Ellis(Founder)inYCYet-Ming Chiang(Founder)inRDRob Davies(Chief Executive Officer)in

BoardKRKatie Rae(Director)inJWJohanna Wolfson(Director)in

Co-investorsAZAzolla VenturesCOCongruent VenturesCRCRH VenturesENEnergy Impact PartnersKHKhosla VenturesLOLowercarbon Capital+4 more

Superlight builds a clean-sheet, aerospace-inspired electric truck for middle-mile cargo transport, using a lightweight aluminium monocoque, software-defined controls, and by-wire architecture to improve payload and operating economics versus diesel.

CleantechLogistics & Supply ChainMobility & Transportation

Co-investorsAVAvila

Optimizing the resources at the heart of every cloud computation.

Cambridge, US

SBSuraj Bramhavar(Director)inJeffery Chou(Executive Officer, Director)

Co-investorsCOCostanoa VenturesNANational Grid Partners

Syzygy Plasmonics converts waste biogas and renewable electricity into sustainable aviation fuel using proprietary photocatalytic technology.

CleantechClimate TechEnergyHouston, US

TBTrevor Best(Executive Officer, Director)inSKSuman Khatiwada(Founder)in

BoardPatrick Poon(Director)Ann DeWitt(Director)MBMichael Biddle(Director)inMatthew Hill(Director)

Co-investorsCLClimate Impact CapitalEVEvok InnovationsGOGOOSE CapitalHOHorizons VenturesLOLotte VenturesNENew Climate Ventures+6 more

TenSixty uses machine learning and cell biology expertise to identify novel antibody targets on cancer cells for the development of new cancer therapeutics.

AI & Machine LearningBiotechMedical DevicesCambridge, US

Daniel Montoro(Executive Officer, Director)inKarthik Jagadeesh(Executive Officer, Director)Christoph Muus(Director)

BoardDipchand Nishar(Director)SCSara Choi(Director)in

Co-investorsCICivilization Ventures Management, LlcGEGeneral CatalystWIWing

Teradar develops terahertz-based sensors for automotive safety, defense, and emerging applications.

Deep TechDefense TechHardwareMobility & TransportationBoston, US

Matthew Carey(CEO & Co-founder)inGCGregory Charvat(CTO & Co-founder)inNSNicholas Saiz(Chief Chip Architect & Co-founder)in

Co-investorsALAlumni VenturesIBIbex InvestorsCACapricorn Investment GroupLOLockheed Martin VenturesVXVXI Capital

Teragen Energy builds modular fuel cell systems for onsite power generation, offering fuel flexibility with optional energy storage and carbon capture.

CleantechEnergyHardware

Co-investorsUNUntroD CapitalAPAP VenturesENEnergy Capital Ventures

Terragia develops consolidated bioprocessing technology using engineered thermophilic bacteria to convert cellulosic biomass, such as crop residues and perennial crops, into ethanol, other biofuels, and co-products at costs competitive with petroleum.

BiotechCleantechEnergy

LLLee Lynd(Founder)inBill Brady(Founder)Chris Herring(Founder)

Co-investorsENEnergy Impact PartnersGEGeneral Catalyst

Terrestrial is developing the Tacterra microarray patch (MAP) platform, which uses dissolvable tips made from biomaterials to deliver therapies such as GLP-1 through the skin without injections.

BiotechDeep TechMedical Devices

RSRachel Sha(CEO)in

Co-investorsGLGlobal Health Investment CorporationRARA CapitalULUlu Ventures

The Routing Company builds a real-time routing algorithm and its Pingo platform for on-demand transit and logistics, reoptimizing routes to increase vehicle seat utilization while maintaining ETAs.

AI & Machine LearningLogistics & Supply ChainMobility & Transportation

AWAlex Wallar(Founder)inMenno van der Zee(Founder)

Co-investorsALAlumni VenturesCOConvergeSYSystemiq CapitalGAGalvanize Climate SolutionsMEMenlo VenturesSYSYSTEMIQ

Acteris is an intelligence layer for industrial robots, including collaborative robots (cobots), built on physical AI to handle high-mix, low-volume production where variable, real-world conditions defeat rigid programming.

Advanced ManufacturingAI & Machine LearningRoboticsSan Jose, US

Asad Tirmizi(Founder)

Co-investorsFIFitz Gate VenturesGEGeodesic CapitalRARadius Capital Ventures

Terrestrial develops the Tacterra microarray patch platform, a dissolvable skin-patch technology for delivering therapies including GLP-1 without injection.

BiotechHealthtechMedical Devices

Livio Valenti(Cofounder)RSRachel Sha(CEO)

Co-investorsMIMission BiocapitalNONorwich VenturesULUlu Ventures

VEIR manufactures low- and medium-voltage superconducting systems that deliver electricity for high-performance AI data centers.

AI & Machine LearningDeep TechEnergyHardwareWoburn, US

THTim Heidel(CEO & Co-Founder)in

BoardDoug Stewart(Director)Adam Wallen(Executive Officer, Director)in

Co-investorsBRBreakthrough Energy VenturesCOCongruent VenturesPIPiva CapitalTYTyche PartnersNANational Grid PartnersVXVXI Capital+5 more

Via Separations makes industrial membrane filtration systems that cut the energy used in thermal separation processes.

Cambridge, US

BKBrent Keller(Executive Officer, Director)inSDShreya Dave(Executive Officer, Director)in

BoardKRKatie Rae(Director)inACArunas Chesonis(Director)in

Co-investorsATATEL VenturesAZAzolla VenturesCACapTableCLClimate InvestmentEMEmbark VenturesPRPrime Impact Fund+3 more

VioNano Innovations develops advanced materials and chemical solutions leveraging nanoscale technology and expertise from the semiconductor and materials science industries.

Advanced ManufacturingDeep TechNew MaterialsSemiconductorsCambridge, US

CTChris Taylor(CEO and Founder)inPHPhil Hustad(CTO and Founder)in

Co-investorsRHRhapsody Venture Partners

Wild Microbes uses synthetic biology to engineer microbes sourced from diverse wild biomes into production hosts for biomanufacturing high-performance ingredients.

BiotechDeep TechNew Materials

TWTimothy Wannier(Founder)in

Co-investorsAGAgronomicsCOCoalitionCOCollaborative FundFRFREEFLOWJUJuniperSISiddhi Capital+2 more

WoHo develops systems to change how buildings are designed and constructed, aligning the efforts of cities, developers, contractors, and designers to improve quality and reduce waste and inefficiency.

Construction TechPropTech

AGAntón García-Abril(Co-Founder & CEO)DMDébora Mesa(Co-Founder, President & CDO)Borja Soriano(Chief Operating Officer)inJavier Cuesta(Chief Technology Officer)Eduardo Cadorniga(Chief Financial Officer)

XGenomes develops genomic sequencing technology using fluorescent probes and machine learning to read genetic and epigenetic information at single-molecule resolution.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesBoston, US

KMKalim Mir(Founder)in

Co-investorsFUFundersClubTHThink+ Ventures Management, LlcY Y CombinatorAMAmino CapitalCACantos VenturesFCFCVC+2 more

Zag Bio develops thymus-targeted bifunctional antibodies designed to induce central tolerance for treating autoimmune diseases.

BiotechDeep TechHealthtechMedical DevicesCambridge, US

Alan Crane(Founder)Diane Mathis(Founder)Joanne Lim(Co-founder)Dr. Diane Mathis(Founder)Jo Viney(Founder)John Kulman(Founder)

Co-investorsLILightspeed Venture PartnersMIMission BiocapitalPEPear VCSASanofi VenturesPOPolaris Partners

Zapata Quantum is a publicly traded company (OTCQB: ZPTA) that develops quantum algorithms and applies agentic AI to automate quantum resource estimation workflows.

AI & Machine LearningDeep TechQuantum ComputingCambridge, US

CSChristopher Savoie(Executive Officer, Director)in

BoardRSReed Sturtevant(Director)inAAAlán Aspuru-Guzik(Director)inRuss Wilcox(Director)

Co-investorsBOBosch VenturesCOComcast VenturesCXCXO FundPRPropagator VenturesRARaptor GroupWOWorldQuant Ventures+7 more