MassVentures

Jaxon builds an API-first verification layer that applies formal logic and executable policy rules to validate LLM outputs before decisions are made, catching hallucinations and enforcing compliance.

AI & Machine LearningDefense TechEnterprise Software

Electrochemical water purifier using patent-pending technology to remove contaminants including PFOA.

Mansfield, US

Julie Bliss Mullen(Executive Officer, Director)Leanne Hersey(Founder)inPamela Lynch(Executive Officer)Orren Schneider(Executive Officer)

BoardJiten Manglani(Director)Tom Ferguson(Director)in

Co-investorsDCVC (Data Collective)Echo River CapitalHG VenturesThe Alchemy FundBURNT ISLAND VENTURES

Aclarity makes the Octa System, an electrochemical oxidation technology that destroys PFAS "forever chemicals" on-site by breaking carbon-fluorine bonds.

CleantechClimate TechHardware

Co-investorsBURNT ISLAND VENTURESEcho River CapitalHG VenturesMaroon Venture Partners Fund

Adden Energy develops solid-state, dynamically-stable batteries based on self-healing separator technology discovered at Harvard, aimed at fast charging, long lifetime, and non-flammable components.

CleantechDeep TechEnergyWaltham, US

William Fitzhugh(Executive Officer, Director)inLuhan Ye(Executive Officer, Director)inXin Li(Executive Officer, Director)in

BoardBernard Lupien(Director)inFred Hu(Director)inLaurie Menoud(Director)in

Co-investorsAt One VenturesRhapsody Venture PartnersPrimavera Venture Management Limited

AeroShield is a materials science company that developed an ultra-clear silica aerogel, originating from research at MIT, aimed at improving the energy efficiency of buildings.

Advanced ManufacturingCleantechEnergyNew MaterialsCambridge, US

Elise Strobach(CEO)inKyle Wilke(Director)inDr. Elise Strobach(CEO)

BoardSusan Stewart(Director)Brandon Tinianov(Director)inStephen Venuto(Director)

Co-investorsClean Energy VentureMassMutual VenturesSBXi

Westborough, US

Co-investorsAlumni VenturesAt One VenturesBasecamp FundBlue Ivy VenturesClean Energy VentureFoothill Ventures+5 more

Building scalable quantum computers with reduced complexity and cost to reach error correction at scale.

Cambridge, US

Bharath Kannan(Executive Officer)Simon Gustavsson(Director)

Co-investorsBlindspot Ventures Management CoChalmers Ventures ABNeotribe VenturesThe E14 FundThe Engine VenturesGlasswing Ventures

BoardOnTrack offers an online board governance and management platform combined with expert coaching, designed for public and charter schools.

EdTechGovTechSaaSConcord, US

Marci Cornell-Feist(Founder)Andrew Jamieson(Chief Technology Officer and Director)

BoardWilliam McCullen(Director)inAlec Stern(Director)Nicholas A. Pappas(Director)

Co-investorsBoston Harbor AngelsLaunchCapitalSustainVC

Clearcut Surgical develops a surgical device that combines electrosurgery, continuous smoke evacuation, and on-demand fluid suction in a single instrument.

HardwareHealthtechMedical DevicesBoston, US

Alex Yang(MD)inJeffery John Caputo(Executive Officer, Director)Heung Bae Kim(MD)

Co-investorsGENERAL INCEPTIONLaunchpad Venture Group

Concerto Bio generates large-scale ecological datasets on microbial communities and uses them to develop microbe-based consumer health products for applications such as skincare, chronic disease, and nutrition.

AI & Machine LearningBiotechDeep TechCambridge, US

Jared Kehe(Executive Officer, Director)Cheri Ackerman(Executive Officer, Director)Bernardo Cervantes(Executive Officer, Director)inVera Schroeder(Director)

BoardSarah Luppino(Director)in

Co-investorsExcelestar VenturesGolden SeedsHorizons VenturesISVM VenturesAxial VC

CYVL provides infrastructure intelligence software that combines purpose-built hardware, computer vision, and AI to process LiDAR and imagery into actionable data on roads, sidewalks, and built assets.

AI & Machine LearningConstruction TechGovTechIoT

Co-investorsPartnership Fund for NYCAero X Ventures

Eden GeoPower develops an Electrical Reservoir Stimulation technology intended to improve the recovery of natural resources with reduced environmental impact.

CleantechDeep TechEnergy

Co-investorsGood Growth CapitalPortfoliaTechEnergy Ventures

Startup cofounded by Emmanuel Kasseris.

Co-investorsVectors AngelThe Engine Ventures

EnVision Endoscopy develops medical devices for gastrointestinal endoscopic surgery, including an Image Guided Suturing System for tissue approximation and management of gastrointestinal defects.

HealthtechMedical DevicesMassachusetts, US

Dr. Azadeh Khanicheh(Founder)Dr. Christopher Thompson(Founder)

BiotechDeep TechMedical DevicesWaltham, US

George Daaboul(Executive Officer, Director)inDavid Freedman(Executive Officer, Director)

BoardPaul Meister(Director)Vinit Nijhawan(Director)inDavid Walt(Director)

Fairmarkit provides an AI-driven autonomous sourcing platform that helps procurement teams competitively source spend across categories at scale.

AI & Machine LearningEnterprise SoftwareSaaS

Tarek Alaruri(Cofounder)Kevin Frechette(Founder)in

Co-investorsInsight PartnersIntrepid Growth PartnersNew Stack VenturesNewfund CapitalNotable CapitalValuestream Ventures+2 more

Feon develops high-performance battery electrolytes using a discovery platform (EDGE) to improve battery performance, safety, and cost across various battery chemistries.

CleantechEnergyNew MaterialsWoburn, US

Zhiao Yu(Cofounder)Wenxiao Huang(Chief Executive Officer and President)

Co-investorsFine Structures VenturesFoothill VenturesValkyrieEight Roads Ventures

Florrent develops bio-based supercapacitors with higher energy density than standard supercapacitors, aimed at short-duration power quality and reliability applications such as data center backup power, grid reliability, and renewables firming.

CleantechDeep TechEnergyAmherst, US

Joseph Hastry(Executive Officer, Promoter)Alexander Nichols(Director, Promoter)Jose LaSalle(Executive Officer, Director, Promoter)

BoardChristopher Noble(Director)Priya Yadav(Director)in

Co-investorsACADEMY INVESTORAIN VenturesNextFab VenturesRaven CapitalBoston Impact Initiative (BII)

Harmony Baby Nutrition develops hypoallergenic, human milk–inspired formula for infants and toddlers with cow's milk protein allergy or sensitivities, using hydrolyzed whey protein, lactose, and HMOs.

ConsumerDirect to ConsumerFoodTech

Del Afonso(Founder)in

Co-investorsBrincPortfoliaSafar PartnersTheVentureCityBig Idea Ventures

Infinite Cooling develops patented technology to capture airborne water droplets and improve the efficiency of evaporative cooling systems such as cooling towers, aiming to reduce water use and energy consumption for industrial customers like power plants.

CleantechClimate TechDeep TechMalden, US

Maher Damak(Executive Officer, Director, Promoter)Kripa Varanasi(Director, Promoter)Karim Khalil(Executive Officer, Promoter)Maher Damak, PhD(Founder)in

BoardCARMICHAEL ROBERTS(Director)inJEFFREY MCCARTHY(Director)

Co-investorsMaterial Impact

InGel Therapeutics develops engineered cell therapies for complex retinal degenerative diseases, combining retinal precursor cells with a biomimetic hyaluronic acid and gelatin hydrogel delivery matrix that mimics the human vitreous.

BiotechDeep TechHealthtech

Patrick Jiang(CEO & Co-founder)Pierre Colombe Dromel(Chief Technology Officer & Co-founder)Deepti Singh(Chief Scientific Officer & Co-founder)in

Co-investorsThe Venture CollectiveZAKA VCService Provider Capital

Inkbit operates an additive manufacturing platform built on Vision-Controlled Jetting, which combines real-time 3D machine vision with closed-loop feedback and a custom material portfolio to produce dimensionally accurate, multi-material parts.

Advanced ManufacturingDeep TechHardwareNew MaterialsMedford, US

Davide Marini(Co-founder & CEO)Javier Ramos(Co-founder & Chief Technology Officer)Wojciech Matusik(Co-Founder & Scientific Advisor)Steffi Kochbeck(VP Market Development)Guy Menchik(Director)Jason Weber(Director)

Co-investorsiGlobe PartnersPhoenix Venture Partners

JetCool builds single-phase, direct-to-chip liquid cooling modules using its microconvective cooling technology to manage heat in high-power electronics such as data center servers, high-performance computing systems, and semiconductors.

CleantechHardwareSemiconductorsLittleton, US

Bernard Malouin Jr.(Executive Officer, Director)Jordan Mizerak(Cofounder)Alexandra Manick(Director)Lawrence Fish(Director)

Co-investorsBosch VenturesRobert Bosch Venture CapitalSchooner CapitalIn-Q-TelRaptor Group

Kytopen develops non-viral gene delivery technology called Flowfect that combines fluid flow with electric fields to deliver payloads such as mRNA, DNA, and CRISPR Cas9 RNP into cells for high-throughput transfection.

BiotechDeep TechHardwareCambridge, US

Cullen Buie(Director)Paulo Garcia(Executive Officer, Director, Promoter)Michael Chiu(Director, Executive Officer)

BoardPaxton Major(Director)Ann DeWitt(Director)inPaul Wotton(Director)

Co-investorsBantam GroupHorizons VenturesSelvedge VentureTBD AngelsTelegraph Hill PartnersThe Engine Ventures+1 more

Labviva is an AI-native procurement platform that unifies the life sciences supply chain, helping research organizations optimize procurement processes and reduce costs.

AI & Machine LearningBiotechEnterprise SoftwareSaaSCambridge, US

SiamakinSiamak Baharloo(Executive Officer, Director)inCarlo(GM of Europe)inNick Premnath(SVP of Commercial Strategy)inAaron Miramontes(Executive Officer)Nicholas Rioux(Executive Officer, Director)in

Co-investorsBIOSPRING PARTNERSGlasswing VenturesVillage GlobalB Capital GroupB4 Capital53 Stations

Lambent is a coaching and business skills training company that trains and certifies executive coaches and provides coaches for businesses internationally.

EdTechFuture of WorkHR TechSutton, US

Joseph O'Connor(Co-founder)Andrea Lages(Co-founder & CEO of Lambent do Brasil)Alejandro Feiges(Managing Director of Administration and Technology, Master Coach Academy)Mike Downing(Director)Julie Johnson(Executive Officer, Director)Charles C. Curran, III(Executive Officer, Director)

Co-investorsArmada Investment AGInovia CapitalGlasswing VenturesGutbrain VenturesNimble VenturesWill Ventures

Lambent Spaces makes software that measures and analyzes space utilization across an organization's entire real estate portfolio, providing data-driven intelligence for space planners.

Data & InfrastructureIoTPropTechSaaS

Julie Johnson Roberts(Co-founder & Chief Strategy Officer)Richard Scannell(Chief Executive Officer)Josh Hartley(VP of Engineering)Beth Quenzel-Shirman(Sr. Director of Accounting and HR)Kate Coble(Senior Director, Marketing)Michael Grant(General Manager - EMEA)

Co-investorsArmada Investment AGGlasswing VenturesGutbrain Ventures

Leuko develops a noninvasive white blood cell monitor to track neutropenia risk in cancer patients and others undergoing treatment.

AI & Machine LearningBiotechDigital HealthMedical DevicesBoston, US

Carlos Castro Gonzalez(Chief Executive Officer)inIan Butterworth(Chief Technology Officer)inPaul Hartung(Director)inAurelien Bourquard(Chief Data Scientist)inAlvaro Sanchez-Ferro(Chief Medical Officer)in

BoardAmy Salzhauer(Director)in

Co-investorsGood Growth CapitalDorm Room

MachineMetrics provides a manufacturing execution system (MES) with AI-powered machine monitoring for discrete manufacturers.

Advanced ManufacturingAI & Machine LearningSaaSEasthampton, US

Co-investorsLevel EquityTola CapitalHyperplane Venture CapitalLRVHealth

Electrified Thermal Solutions builds the Joule Hive Thermal Battery, a thermal energy storage system that runs electricity through electrically-conductive E-bricks to store off-peak power as heat up to 1,800°C and deliver zero-carbon industrial heat to furnaces, boilers, and kilns.

CleantechClimate TechEnergySan Antonio, US

Co-investorsClean Energy VentureClean Energy VenturesTechEnergy VenturesStarlight Ventures

Myrias Optics designs, develops, and manufactures high-performance metalenses, covering research and development through high-volume production.

Advanced ManufacturingDeep TechHardwareAmherst, US

James J. Watkins(Executive Officer, Director)Jim Watkins(Founder and CSO)Vincent Einck(Co-Founder and CTO)James Joseph Watkins(Executive Officer, Director)John Fijol(CEO)Patrick Tan(Executive Officer, Promoter)

Co-investorsMaroon Venture Partners FundTenon Ventures

Osmoses develops a membrane technology for purifying and separating gas molecules, aimed at making industrial gas separation processes more energy-efficient.

CleantechClimate TechDeep TechNew MaterialsBoston, US

Francesco Benedetti(Co-Founder & CEO)Katherine Mizrahi Rodriguez(Co-Founder & Chief Implementation Officer)inZachary P. Smith(Co-Founder / Associate Professor, MIT)

Co-investorsBlindspot Ventures Management CoFine Structures VenturesNew Climate VenturesOrbia VenturesThe Engine Ventures

Pison makes a neural wearable watch that reads the electrical signals between the brain and muscles to measure and train cognitive performance alongside standard physiological metrics like heart rate, HRV, strain, and sleep.

HardwareHealthtechWellness & Fitness

Co-investorsCoalitionDorm RoomLavrock Ventures

Revinova provides a learning platform and AI agent embedded in clinical trial management systems (CTMS) to train sites for clinical trials and reduce protocol deviations.

AI & Machine LearningHealthtechSaaS

Seaspire develops safe and sustainable suncare and skincare products using Xanthochrome®, a proprietary class of biomolecules inspired by oceanic compounds.

Advanced ManufacturingBiotechConsumerDirect to ConsumerWellness & FitnessCambridge, US

Camille A. Martin(CEO and co-founder)Leila Deravi(Co-founder and scientific advisor)Camille Martin, PhD(Founder)in

Co-investorsHuntington Angels NetworkSafar PartnersTechstarsThe Engine VenturesAlumni Ventures

Spiro is an AI-powered CRM platform built specifically for manufacturers, combining ERP integration and automation to reduce manual data entry and help sales teams work more efficiently.

Advanced ManufacturingAI & Machine LearningEnterprise SoftwareSaaSBoston, US

Adam Honig(President)inJustin Kao(Chief Operating Officer)inJennifer Jordan(Director)Omar Hussain(Director)Andrew Levi(Director)Thomas Tucker(Director)

Co-investorsBantam GroupGeekdomNXT VenturesHyperplane Venture Capital

AI & Machine LearningDigital HealthHealthtechMedical DevicesBoston, US

Daniel Lookadoo(Executive Officer)Sidhant Jena(Executive Officer, Director)

BoardDonald Ingber(Director)Amarpreet Sawhney(Director)

Subconscious develops TIMRUN, an inference runtime, and the TIM family of post-trained open models optimized for AI agent workloads rather than chatbots, offering on-GPU context compression that extends context windows and increases concurrency and token throughput.

AI & Machine LearningDeep TechDeveloper Tools

Jack O'Brien(Founder)in

Co-investorsFoothill VenturesOakseed VenturesEntrepreneur FirstYourNest Venture Capital

AI & Machine LearningEnergyHardwareSomerville, US

Joel L. Dawson(Executive Officer, Director)

Transaera develops heat pump systems and Dedicated Outdoor Air Systems (DOAS) that use novel materials to dehumidify, cool, and heat air for commercial buildings.

CleantechClimate TechEnergyHardwareSomerville, US

Sorin Grama(Co-founder)inMircea Dinca(Co-Founder & CS)in

BoardAshwin Shashindranath(Director)inMatthew Cohen(Director)inMitch Tyson(Director)inRoss Bonner(Co-founder & CTO)in

Co-investorsClean Energy VentureClean Energy VenturesEnergy Impact PartnersJuniperMassMutual Ventures

Z-Polymers develops ultra-fine polymer fiber and filament, including its Tullomer super-polymer, for applications across manufacturing, textiles, civil engineering, medical, healthcare, aerospace, and construction.

Advanced ManufacturingDeep TechNew MaterialsLowell, US

Mike Zimmerman(Founder)in

Co-investorsAsimov VenturesService Provider Capital