How many investments has R42 Group made?

R42 Group has 10 tracked investments, including 3 dated in the last 24 months.

What stage does R42 Group invest at?

R42 Group invests at the Pre-Seed, Seed stages.

Where is R42 Group located?

R42 Group is headquartered in San Francisco.

Does R42 Group lead rounds?

Yes, R42 Group leads investment rounds.

R42 Group

Family office

San Francisco · Pre-Seed–Seed · 13 people tracked

Also known as R42

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Investment thesis

R42 focuses on artificial intelligence and science, drawing on a team of scientific advisors and the experience of founder Dr. Ronjon Nag. The firm operates a dual strategy: it invests directly in early-stage companies, leading and backing them from the earliest stages — even when a startup is only an idea without a team — and it invests as a limited partner in funds that share its values, sometimes co-investing alongside those funds. R42 has backed roughly 50 companies, providing founders with hands-on guidance, resources, and access to expert advisors to help accelerate their growth.

Invests inAI & Machine Learning Biotech Deep Tech Hardware Healthtech Longevity SaaS Palo Alto San Francisco

Source: firm website, verified Aug 16, 2026.

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Stage

Pre-Seed–Seed

San Francisco

Leads rounds

Leads

Instruments

Equity

Founded

2020

Last 12 months

2 investments

Tracked investments

Team · 13 people

from the firm's website & public directories

Ronjon Nag· Founder

Dr. Ronjon Nag is an entrepreneur and AI pioneer who cofounded and advised companies acquired by Motorola, BlackBerry, and Apple. He established R42 out of his family office.

Anastasiya Giarletta· Principal· Los Angeles Metropolitan Areain

Principal at R42 Group who evaluates companies in longevity science and artificial intelligence.

Anne Friedlander· Adjunct Professor, Human Biology, Stanford University

Adjunct Professor in Human Biology at Stanford University and an advisor to the firm.

Artem Trotsyuk· Entrepreneur in Residence

Bioengineer and computer scientist who studied at UC Davis and earned a PhD in BioEngineering from Stanford University.

Eric Saund· Cognitive Science Researcher, AI/ML Consultant

Researcher in cognitive science and a consultant in AI and machine learning.

Frank Sortino· Director, Pension Research Institute

Director at the Pension Research Institute and creator of the Sortino Ratio.

Joel Naor· Entrepreneur in Residence

Physician executive with extensive experience across large, small, and early-stage biotech companies, having served as chief medical officer for public and private firms developing biologics, small molecules, stem cells, and other therapies.

Michael Snyder· Stanford Professor, Chair of Genetics Department

Stanford Ascherman Professor and Chair of the Genetics Department.

Pavan Manocha· Sustainability & Longevity Investor; Yoga for Aging Prevention Researcher

Certified yoga teacher and scholar on the science of yoga in aging prevention, serving as an adjunct professor, venture investor, and limited partner at R42 Group.

Rickmer Kose· Nanotechnology Expert; LiDAR, Autonomous Vehicles

Advisor with over 30 years of experience in technology and entrepreneurship, specializing in nanotechnology, LiDAR, and autonomous vehicles.

Sohila Zadran· Entrepreneur, Expert in Biotechnology and Digital Health

Entrepreneur and expert in biotechnology and digital health who studied Molecular Cell Biology at UC Berkeley.

Steve Toteda· Global Executive in Water, Energy and Communications Technology

Global executive with 25 years of leadership experience in the water, energy, and communications sectors.

Zixuan An· Venture Associate· Palo Alto, California, United Statesin

Supports fund operations, portfolio management, growth strategy, and investor relations. Holds BA degrees in Psychology and Philosophy from UC Santa Cruz and a tech-intensive MBA from Cornell University.

What they invest in

from 9 of 10 portfolio companies

Biotech ×7Deep Tech ×5Healthtech ×5AI & Machine Learning ×3Digital Health ×2Hardware ×2Longevity ×2Medical Devices ×2

HQs:United Kingdom×6United States×3

Investments · 10 tracked

founders shown can be your intro path

By year:2026 · 1 2025 · 1 2024 · 2 2022 · 4 2021 · 19 dated

xWattsxwatts.co inFeb 2026✓ verified

xWatts is an intelligent energy management platform that connects to building energy systems, models facilities in real time, and automatically optimizes assets like HVAC, solar, and CHP engines to reduce energy costs and emissions in large, complex estates and industrial facilities.

CleantechClimate TechEnergyEnterprise SoftwarePropTech

Yigit Akar(Co-founder & CEO)inAlex Allen(Co-founder & CPO)Alexander A.(Founder)in

Co-investorsAntler Cambridge Angels group Parkwalk Advisors Plug and Play Ventures

Abselionabselion.com in 𝕏Dec 2024

Abselion develops measurement tools and a platform combining hardware, purpose-built assay formats, and software for biological measurements such as protein quantification.

BiotechDeep TechHardwareMedical DevicesCambridge, GB

Dr Ruizhi Wang(CEO)

Co-investorsCambridge Angels group M Ventures

Bounce Imagingbounceimaging.com in 𝕏May 2022 · $4.2M

Bounce Imaging manufactures tactical 360-degree camera systems and robotics for first responders, law enforcement, and military personnel to safely assess confined spaces.

Defense TechHardwareRoboticsBuffalo, US

Francisco Aguilar(Executive Officer, Director)in Ronjon Nag(Director)inJames Smist(Director)Sietse Dijkstra(Executive Officer)inMark Fargason(Executive Officer)inMikhail Fridberg(Executive Officer)in

Co-investorsIn-Q-Tel Bantam Group Berkeley Angel Network Broad Street Angels Brown and White Ventures DC Investment Partners +7 more

Cordance Medicalcordancemedical.com in 𝕏Nov 2025

Cordance Medical develops medical technology focused on diagnosing and treating patients with brain diseases, drawing on expertise from neurosurgery, neuroimaging, and biomedical engineering.

AI & Machine LearningBiotechDeep TechDigital HealthHealthtechMedical DevicesMountain View, US

Ryan Dittamore(CEO)in

Co-investorsAngel Physicians Fund Beresford Ventures Black Mountain Ventues Creative Destruction Lab (CDL)Shanda Group SmartGateVC +1 more

Exogeneexogene.co.ukApr 2022

Exogene is a techbio startup using a generative AI and deep learning platform to discover novel, high-affinity TCR-based (T-cell receptor) therapies for treating solid tumors.

AI & Machine LearningBiotechDeep TechHealthtechOxford, GB

Federico Paoletti(CEO & Co-Founder)in Andrea Mambrini(CTO & Co-Founder)in

Co-investorsBeresford Ventures Entrepreneur First Jude Gomila Selvedge Venture Unruly Capital Cambridge Angels group +1 more

Fountain Therapeuticsfountainml.com inNov 2021

Fountain is a biotech company developing first-in-class therapies for diseases and conditions caused by aging, using in vitro and in vivo screening platforms to identify drug candidates.

BiotechHealthtechLongevitySan Francisco, US

Thomas Rando(Co-founder)Joseph Rodgers(Co-founder)in Tom Cheung(Co-founder)inTsang(Chief Business Officer)

Co-investorsAlexandria Khosla Ventures Nan Fung Life Sciences

Healxhealx.ai in 𝕏Aug 2024 · $47M

Healx uses artificial intelligence to redevelop, combine, and enhance known compounds to build a pipeline of therapies for rare diseases, with an expanding focus on oncology and preventing cancer recurrence.

AI & Machine LearningBiotechDigital HealthHealthtechCambridge, GB

Tim Guilliams(Founder)inDr David Brown(Co-Founder and Board member)inDavid J. Brown(Founder)in

Co-investorsAmadeus Capital Partners Aurum Venture Partners Balderton Capital Cambridge Angels group Daniel Gutenberg Global Brain +4 more

Seniscasenisca.com

SENISCA is a University of Exeter biotech developing RNA-based senotherapeutics that target dysregulated RNA splicing to reverse cellular senescence and treat age-related disease.

BiotechDeep TechLongevity

Lorna Harries(Founder)in

Co-investorsAPEX Ventures Lifespan Vision Ventures

Spireaspirea.co.uk inJun 2022 · $3M

Spirea develops a multivalent ADC linker technology called ELIVATE that expands the range of usable payloads for antibody-drug conjugates, aiming to enable next-generation ADCs for oncology, inflammation, and autoimmune diseases.

BiotechDeep TechHealthtech

Myriam Ouberai(Founder)inBo Rode Hansen(Executive Director)in

Co-investorsCambridge Angels group Start Codon ACF Investors O2h Ventures

Stampstamp.eeMay 2022

This is a domain sales landing page offering the premium .ee domain "stamp.ee" for purchase, operated by Computernik OÜ.

Co-investorsNielsen Innovate Second Century Ventures

Portfolio news

latest coverage across their companies

xWatts Raises £1.6M in Seed Funding | The SaaS News

xWatts · thesaasnews.com · Feb 10, 2026

Cordance Medical Announces an Oversubscribed $8M Seed Financing to Advance Focused Ultrasound Platform for Brain Disease Treatment

Cordance Medical · prnewswire.com · Nov 24, 2025

Frequently asked questions

How many investments has R42 Group made?: R42 Group has 10 tracked investments, including 3 dated in the last 24 months.
What stage does R42 Group invest at?: R42 Group invests at the Pre-Seed, Seed stages.
What sectors does R42 Group focus on?: R42 Group focuses on AI & Machine Learning, Biotech, Deep Tech, Hardware, Healthtech, Longevity, SaaS.
Where is R42 Group located?: R42 Group is headquartered in San Francisco.
Does R42 Group lead rounds?: Yes, R42 Group leads investment rounds.

Media · Podcasts & interviews

featuring the team

Can We Hack the Aging Code? Dr. Ronjon Nag on Using AI to Cure Cancer & Extend Life- R42 Group

Ones Changing The World - 1CW · Ronjon Nag

Images

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