Longwood Fund — Full Portfolio

Pyxis Oncology develops antibody-drug conjugates and immunotherapies targeting difficult-to-treat cancers to improve patient outcomes.

BiotechDigital HealthHealthtechMedical DevicesBoston, US

Thomas Civik(Interim Chief Executive Officer, Director)

BoardGVGeeta Vemuri(Director)inJak Knowles(Director)John Flavin(Director)

Board seatDSDavid SteinbergCWChristoph Westphal· per SEC Form D

Co-investorsAGAgent CapitalLILifeSci Venture PartnersPFPfizer Venture InvestmentsRARA CapitalTRTrans-Pacific Technology FundRTRTW Investments L.P.

Bicycle Therapeutics develops precision-guided therapeutics based on its proprietary bicyclic peptide (Bicycle) technology, designed to penetrate deep into tissues and target intractable solid tumor cancers.

BiotechHealthtechCambridge, GB

GWGregory Winter(Director)inNCNIGEL CROCKETT(Executive Officer)inNKNICHOLAS KEEN(Executive Officer)SASANTIAGO ARROYO(Executive Officer)inMICHAEL HANNAY(Executive Officer)MICHAEL SKYNNER(Executive Officer)in

Co-investorsAHAhren Innovation CapitalASAstellas Venture Management LLCCACambridge Innovation CapitalDEDementia Discovery FundRIRidgeback CapitalSRSR One Capital Management+4 more

GRAIL develops the Galleri blood test for multi-cancer early detection using next-generation sequencing and machine learning to screen for multiple deadly cancer types before symptoms appear.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesMenlo Park, US

Jeffrey T. Huber(Director)JOJoshua Ofman, MD, MSHS(Chief Executive Officer)inAFAaron Freidin(Executive Officer)inRobert Ragusa(Executive Officer, Director)JCJennifer Cook(Executive Officer, Director)inRichard Klausner(Director)

Co-investorsAMAmino CapitalARARCH Venture PartnersBEBezos ExpeditionsBLBluebird VenturesDEDecheng CapitalDEDentsu Ventures+13 more

PTC is a global pharmaceutical company focused on the discovery, development, and commercialization of medicines for patients with rare diseases who have few or no treatment options.

BiotechHealthtechSouth Plainfield, US

Stuart W. Peltz(Executive Officer, Director)Allan Jacobson(Director)inMEMark E. Boulding(Executive Officer)inCUChristine Utter(Executive Officer)inMSMarcio Souza(Executive Officer)inNANeil Almstead(Executive Officer)in

Co-investorsBABay City Capital

Verastem Oncology is a biopharmaceutical company that discovers and develops drugs to treat cancer patients.

BiotechMedical DevicesNeedham, US

RWRobert WeinbergRICHARD ALDRICH(Director)ACAMY C. CAVERS(Executive Officer)inCCCATHY CAREW(Executive Officer)inJPJONATHAN PACHTER(Executive Officer)inRGROB GAGNON(Executive Officer)in

Co-investorsBEBessemer Venture PartnersCACardinal PartnersFOForesite CapitalLILightstone VenturesOBOberland CapitalVIViking Global+1 more

Engrail Therapeutics is a clinical-stage pharmaceutical company developing precision-targeted therapeutics for neupropsychiatric and neurodevelopmental disorders.

BiotechDigital HealthMedical DevicesSan Diego, US

Stephen(Co-founder, EVP Research & Development and Chief Development Officer)Paul Cayer(Chief Financial Officer)inVikram(President and Chief Executive Officer)Kimberly(Chief Scientific Officer)Quentin(Chief Technical Officer)

Co-investorsFOForesite CapitalNONorwest Venture PartnersPIPivotal Life SciencesRIRiverVest Venture PartnersYSYsios CapitalEIEight Roads Ventures+3 more

Newleos is a biopharmaceutical company developing therapies for neuropsychiatric and neurodevelopmental disorders.

Biotech

Federico Bolognani(Co-founder, Chief Medical Officer)CWChristoph Westphal(Co-founder, Director)

Photys Therapeutics develops bifunctional small-molecule medicines that use induced proximity to recruit kinases and drive targeted protein phosphorylation, aiming to modulate and repair disease-driving proteins.

BiotechHealthtechLongevityWaltham, US

Amit Choudhary(Scientific Founder)DSDavid Steinberg(Chairman & Founding CEO)inEHEdward Holson(Co-founder & CSO)inLNLizzie Ngo(Co-founder)inBrian Fenton(President & CEO)in

Co-investorsMPMPM BioImpact8V8VCMRMRL Ventures FundONOno Venture Investment, Inc.

Sitryx is a biotechnology company, founded in 2018, developing therapeutics with a focus on immunometabolism.

BiotechDeep TechHealthtech

Co-investorsOXOxford Science EnterprisesSOSofinnova PartnersSVSV Health InvestorsDEDementia Discovery Fund

Anuncia Medical develops medical technology focused on cerebrospinal fluid (CSF) science and clinical strategy to advance hydrocephalus treatment.

BiotechHealthtechMedical DevicesScottsdale, US

Darryl Baker(Executive Officer)EAElsa Abruzzo(Executive Officer, Director)in

BoardEdgar D Janotta(Director)Stanton Rowe(Director)Stephen Oesterle(Director)

Board seatDavid Donabedian· per SEC Form D · $16.4M raise · filed Nov 2025

Co-investorsARArieal Southeast Angel PartnersXCXcellerant Ventures

HealthtechLexington, US

Barbara S. Fox(Executive Officer, Director)Eileen F. Bostwick(Executive Officer)David C. Dlesk(Executive Officer)David Poorvin(Executive Officer, Director)

BoardJonathan Fleming(Director)

Board seatDavid Donabedian· per SEC Form D · $5M raise · filed Jul 2015

Co-investorsBOBoston Harbor AngelsKEKeiretsu Forum

The page presents Pinco Casino, an online gambling platform offering slots, live casino, table games, and sports betting with a Turkish-language interface.

ConsumerGamingHealthtechBoston, US

Robert Kotin(Executive Officer, Director)Chen Schor(Director)Robert Hadfield(Executive Officer)John Lawrence(Executive Officer)

BoardGVGeeta Vemuri(Director)inDYDerek Yoon(Director)in

Board seatDSDavid Steinberg· per SEC Form D

Co-investorsASAstellas Venture Management LLCDCDC Investment PartnersSOSolasta VenturesUTUTokyo Innovation Platform Co. Ltd.AGAgent Capital

Colorescience is a professional skincare brand that develops mineral-based sun protection (SPF), skincare, and color correction products, originally created for post-procedure skin and marketed for all ages and skin types.

ConsumerDirect to ConsumerHealthtechWellness & FitnessCarlsbad, US

Stephen Loomis(Executive Officer)MFMary Fisher(Executive Officer, Director)inTheodore Ebel(Executive Officer)Josie Juncal-Schwarz(Executive Officer)

BoardM Bolyard(Director)Brian Dovey(Director)in

Board seatRichard Aldrich· per SEC Form D

Co-investors131315 CapitalAIAisling CapitalRERevelation PartnersRORoundTable Healthcare PartnersDODomain AssociatesHEHealthCare Ventures, LLC+2 more

Immunitas discovers and develops therapeutic antibodies for cancer and autoimmune diseases, with its lead program targeting CD161 for solid tumors and hematological malignancies.

BiotechDigital HealthMedical DevicesWaltham, US

AWAmanda Wagner(CEO)inDan Matloff(Executive Officer)Jiaping Gu(Director)Jeffrey Goldberg(Executive Officer, Director)

BoardLBLaura Brass(Director)inKWKai Wucherpfennig(Director)

Board seatCWChristoph Westphal· per SEC Form D

Co-investorsAGAgent CapitalDCDC Investment PartnersLILifelinkM M VenturesMEMedical Excellence CapitalNONovartis Venture Fund+5 more

BiotechBoston, US

David Donabedian(Executive Officer, Director)inRHRobert Hadfield(Executive Officer)inJMJohn McCabe(Executive Officer)in

BoardMing Cheah(Director)inRCRaymond Camahort(Director)

Board seatCWChristoph Westphal· per SEC Form D

Co-investorsDCDCVC (Data Collective)DCDCVC BioARArkin CapitalNONovo Holdings

Axena Health is a women's health company providing non-invasive, clinically tested treatments for pelvic health conditions.

Digital HealthFemTechMedical DevicesBoston, US

Jim O'Connor(Executive Officer)EMEileen Maus(Executive Officer, Director)

BoardTara Butler(Director)Adam Stone(Director)Dan Levangie(Director)

Board seatRARich Aldrich· per SEC Form D

Co-investorsASAscension VenturesWEWestern Technology InvestmentOSOSF Ventures

A company focused on developing clinical treatments aimed at improving patient outcomes.

BiotechHealthtechMedical DevicesBoston, US

DSDavid Southwell(Executive Officer, Director)inRobert Crane(Executive Officer)

BoardSKSteve Kraus(Director)inCMCampbell Murray(Director)inHSHannes Smarason(Director)in

Board seatChristoph WestphalCWChristoph WestphalLHLea Hachigian· per SEC Form D

Co-investorsASAstellas Venture Management LLCBEBessemer Venture PartnersGVGV (Google Ventures)PIPitangoRARA Capital6 6 Dimensions Capital

An R&D-driven biopharmaceutical company that uses AI to develop breakthrough medicines and vaccines focused on immune system disorders across five therapeutic areas.

AI & Machine LearningBiotechMedical DevicesCambridge, US

IMIvana Magovcevic-Liebisch(Executive Officer, Director)CVChristopher Verni(Executive Officer)inMary Thistle(Director)Evan Thackaberry(Executive Officer)Suzanne Bruhn(Director)Gerhard Koenig(Director)

Board seatShaan C. Gandhi· per SEC Form D · $75M raise · filed Aug 2022

Co-investorsATAtlas VentureHAHatteras Venture PartnersLILightstone VenturesPIPivotal Life SciencesVIVida Ventures

Werewolf Therapeutics is a biotechnology company developing immunotherapy treatments for cancer.

BiotechHealthtechMedical DevicesWatertown, US

Daniel J. Hicklin(Founder, President, Chief Executive Officer, and Board member)LELuke Evnin(Co-founder, Board member (Chairman))inDavid Cordo(Executive Officer)Alon Lazarus(Director)

BoardBMBriggs Morrison(Director)in

Board seatCWChristoph Westphal· per SEC Form D

Co-investorsDCDC Investment PartnersK2K2 HealthVenturesMPMPM BioImpactRARA CapitalTATaiho Ventures, LLCUPUPMC Enterprises

Clinical-stage gene therapy company developing AAV therapeutics for inherited retinal disorders.

Co-investorsNENeva Sgr.SISixty Degree CapitalSOSofinnova PartnersXGXGEN VentureATAtlas VentureFOForbion

Neomorph develops a molecular glue discovery platform to identify small-molecule medicines that degrade disease-causing proteins through targeted protein degradation.

AI & Machine LearningBiotechDeep TechSan Diego, US

Co-investorsDEDeerfield Management Company

HealthtechBoulder, US

JMJason Myers(Executive Officer, Director)Christian LaPointe(Executive Officer)

BoardKLKyle Lefkoff(Director)inPMPaul Manning(Director)in

Co-investorsCRCrawley VenturesBOBoulder VenturesPBPBM CapitalREREDMILESASands Capital VenturesSOSoleus Capital

Avenzo Therapeutics is a clinical-stage biopharmaceutical company developing therapeutic treatments.

BiotechSan Diego, US

ACAthena Countouriotis(Co-Founder, Chief Executive Officer)Mohammad Hirmand(Executive Officer)inPaolo Tombesi(Executive Officer)inScott Lipman(Executive Officer)inBSBrian Sun(Executive Officer)in

BoardCarl Gordon(Director)

Co-investorsDEDelos CapitalFOForesite CapitalININCE CapitalNENew Enterprise Associates (NEA)OROrbiMedQUQuan Capital+6 more

Restaurant tech company; $100M exit.

Co-investorsANAnalog VenturesBRBranded Strategic HospitalityFOFour Acres CapitalGVGV (Google Ventures)RARally Ventures Management, LlcSUSupernode Ventures+2 more

BridgeBio develops treatments for genetic conditions and cancers using a decentralized hub-and-spoke model, where autonomous teams focus on specific diseases or drug candidates while a central hub provides clinical, regulatory, and commercial support.

BiotechHealthtech

Neil Kumar(Founder)

Co-investorsAIAisling CapitalAMAmzak HealthECEcoR1 CapitalFRFrazier Life SciencesHEHEALTHCARE ROYALTY PARTNERSHEHercules Capital, Inc.+3 more

Calithera Biosciences was a clinical-stage biopharmaceutical company developing small-molecule oncology drugs targeting tumor metabolism, including the glutaminase inhibitor telaglenastat.

BiotechSouth San Francisco, US

Susan M. Molineaux(Executive Officer, Director)inWWWilliam Waddill(Executive Officer)in

BoardJean M. George(Director)DPDeepa Pakianathan(Director)inRalph E. Christoffersen(Director)Jonathan Drachman(Director)

Co-investorsVEVenture Capital Investment ManagementTHThe Column Group

HealthtechEmeryville, US

Bill Malecki(Executive Officer)Daniel Burnett(Director)Ulric Cote(Executive Officer, Director)

BoardDr. Jason Hong(Director)ANAnthony Natale(Director)inCarter Mayer(Director)

Co-investorsAPAPERTURE Venture PartnersGRGreen Park & Golf VenturesSCScientific Health DevelopmentTHThird Point VenturesVHVHM

Coultreon is a drug discovery and development company that advances small and large molecule therapeutic programmes across various disease areas, combining disease biology expertise with technology platforms.

AI & Machine LearningBiotech

PRPierre Raboisson(Chief Executive Officer Chief Scientific Officer Co-founder)inMDMarie De Vulder(Chief Legal Officer Co-founder)inGPGuy Peeters(Chief Financial Officer Co-founder)inJGJohn-Paul Gallivan(Head of Development Co-founder)inFKFabrice Kolb(Head of Immunology Co-founder)inPieter Peeters(Operating & Technology Officer Co-founder)in

Co-investorsFIFinchley Healthcare VenturesLULuma GroupSOSofinnova VenturesBABAM ElevateFOForbionNONovo Holdings+2 more

Crystalys Therapeutics is a clinical-stage biopharmaceutical company developing targeted therapies for gout, a chronic metabolic disease caused by elevated uric acid.

BiotechHealthtechMedical DevicesSan Diego, US

JMJames Mackay(President & Chief Executive Officer)inNihar Bhakta(Chief Medical Officer)inAshwin Ram(Chief Operating Officer)inDeAnne Reid(Chief Administrative Officer)in

Co-investorsCACatalys PacificNONovo HoldingsANAN Venture PartnersFRFrazier Life SciencesLILightstone VenturesPOPontifax Venture Capital

DEM BioPharma is a biotechnology company developing cancer therapies by targeting the immune system, drawing on genetic and immuno-oncology research.

BiotechHealthtechCambridge, US

NGNenad Grmusa(Chief Executive Officer)inJMJohn McCabe(Chief Financial and Operating Officer)in

Co-investorsALAlta PartnersASAstellas Venture Management LLCDCDC Investment PartnersPFPfizer Venture InvestmentsUTUTokyo Innovation Platform Co. Ltd.INInsight Partners+1 more

Evommune develops therapies targeting the underlying sources of chronic inflammatory diseases, aiming to provide underserved patient populations with more than symptomatic relief.

BiotechHealthtechPalo Alto, US

LPLuis Pena(President & Chief Executive Officer)inJanice Drew(Executive Officer)David Cohen(Director)Gregory Moss(Executive Officer)Eugene Bauer(Executive Officer, Director)Francois Beaubien(Director)

Co-investorsANAndera PartnersAVAvego BioScience CapitalB B Capital GroupB4B4 CapitalBEBeiersdorf Innovation FundFEFemHealth Ventures+4 more

Flex Pharma provides accessible generic vasodilator medications, including PDE5 inhibitors, to U.S. patients at lower costs than brand-name alternatives.

BiotechDigital HealthHealthtechMedical Devices

Dr. Rod MacKinnon(Founder)

Co-investorsBEBessemer Venture PartnersECEcoR1 CapitalLILightstone Ventures

Flexiv builds adaptive robots featuring force control, including the Rizon seven-axis robotic arm and Hesper robot controller.

Advanced ManufacturingAI & Machine LearningDeep TechEnergyHardwareRoboticsSilicon Valley, US

SWShiquan Wang(Co-Founder and Chief Executive Officer)inXYXiyang Yeh(Co-Founder and Chief Technology Officer)in

Co-investorsPLPlug and Play VenturesZHZhenFundGAGaorong CapitalGAGaorong VenturesGSGSR VenturesINInvus+1 more

IlluminOss Medical makes a light-curable, patient-conforming intramedullary implant for minimally invasive fracture repair.

Co-investorsEXExcel Venture ManagementPAPappas CapitalSLSlater Technology Fund

BiotechPhiladelphia, US

Philip R. Johnson, M.D.(Executive Officer, Director)inDora Mitchell(Executive Officer)LFLori Forrest(Executive Officer)Leon Moulder, Jr.(Director)BLBenjamin Lund(Director)in

BoardTomas Kiselak(Director)

Co-investorsAGAgent CapitalDCDC Investment PartnersOUOUP (Osage University Partners)PFPfizer Venture InvestmentsQUQuan CapitalBABain Capital Life Sciences+3 more

KalVista Pharmaceuticals is a global biopharmaceutical company that develops oral therapies for rare diseases, starting with hereditary angioedema (HAE).

BiotechHealthtech

Co-investorsFRFrazier Life SciencesRARA Capital

Khartis is a drug discovery company developing oral therapies for patients with immune-mediated and chronic diseases.

BiotechMedical DevicesSan Diego, US

Robert Hoffman(Founder; CEO & Head of Research)Craig Murphy, PhD(Founder; Chief Scientific Officer)Chris LeMasters, MBA(Founder; Executive Board Chairman)

Co-investorsFOForesite CapitalNENextech InvestALAlexandriaLILilly Asia Ventures

Lassen Therapeutics is a biotechnology company developing therapeutics targeting IL-11, with a pipeline focused on immune and fibrotic diseases.

Biotech

DKDavid King(Co-Founder & CSO)inMFMaria Fardis(CEO)inCCCadmus C. Rich(Chief Medical Officer)inESElaine Stracker(General Counsel)in

Co-investorsALAlta PartnersCACatalio Capital Management, LPDCDC Investment PartnersFRFrazier Life SciencesLOLongitude CapitalBIBiotechnology Value Fund+2 more

Mediartx develops novel therapies for patients with fibrotic diseases.

BiotechMedical DevicesBoston, US

Rahul Ballal, PhD(CEO)PYPaul Yaworsky, PhD(CSO)inRBRahul Ballal(Executive Officer, Director)inBrian Hubbard(Director)Stacey Brenner(Executive Officer)David de Graaf(Director)

Co-investorsAGAgent CapitalGIGimvMIMission BiocapitalNONovartis Venture FundONOno Venture Investment, Inc.PFPfizer Venture Investments+5 more

Progentos develops small-molecule therapeutics to stimulate myelin regeneration in multiple sclerosis patients by activating oligodendrocyte progenitor cells.

BiotechDeep TechMedical DevicesWatertown, US

DHDmitrij Hristodorov(Director)inChristopher Loose(Executive Officer, Director)Sanjay Magavi(Executive Officer)MTMarc-Olivier Turgeon(Director)in

BoardARAleks Radovic-Moreno(Director)inDan Janney(Director)

Co-investorsALAlta PartnersDODolby Family VenturesMIMission BiocapitalSEService Provider CapitalFOForbion

Pulmocide is a biopharmaceutical company developing inhaled therapies for difficult-to-treat respiratory diseases, currently focused on respiratory fungal infections such as pulmonary aspergillosis.

BiotechHealthtech

PSPete Strong(Co-founder)Garth Rapeport(Co-founder)inKazuhiro Ito(Co-founder)inJohn Murray(Co-founder)inDMDavid Mantusin

Co-investorsADAdjuvant CapitalASAsahi Kasei Corporate Venture CapitalDEDementia Discovery FundF-F-Prime CapitalJEJeito CapitalSRSR One Capital Management+4 more

Rectify Pharma is a biotechnology company developing therapies, with a pipeline that has included work in liver and metabolic disease areas.

BiotechDeep Tech

RDRajesh Devraj(President and Chief Executive Officer)inRHRobert Hughes(Chief Scientific Officer)inPBPol Boudes(Chief Medical Officer)

Co-investorsATAtlas VentureDCDC Investment PartnersFOForbion

Boston-based biotech developing drugs against the 'dark genome'/repeatome for autoimmune disease, cancer and neurodegeneration.

Benjamin Greenbaum(Founder)David Ting(Founder)Rosana Kapeller(Founder)

Co-investorsANAndreessen HorowitzARARCH Venture PartnersGVGV (Google Ventures)LULuma GroupSASanofi VenturesABAbingworth+11 more

Sidewinder Therapeutics is a biotechnology company focused on oncology drug discovery and development, working on next-generation cancer treatments.

BiotechHealthtechMedical DevicesSan Diego, US

EMEric Murphy(Chief Executive Officer, Co-Founder, & Director)in

Co-investorsASAstellas Venture Management LLCDCDCVC (Data Collective)DCDCVC BioFRFrazier Life SciencesNONovartis Venture FundOROrbiMed+2 more

Solu Therapeutics is a clinical-stage biotech developing a class of antibody therapeutics that link bifunctional small molecules to proprietary effector antibodies (its CyTAC and TicTAC platforms) to reach cell surface targets like GPCRs and ion channels.

BiotechHealthtech

PVPhil Vickers(CEO / Leadership)inMBMichael Boretti(Leadership)inBTBrandon Turunen(Leadership)inSSSergio Santillana(Leadership)EMEnda Moran(Leadership)inKHKelly Honohan(Leadership)in

Co-investorsASAstellas Venture Management LLCPAPappas Capital

Xaira develops AI and machine learning tools for drug discovery and protein design, serving pharmaceutical and biotech companies.

AI & Machine LearningBiotechMedical DevicesSouth San Francisco, US

Hetu Kamisetty(Founder)MTMarc Tessier-Lavigne(Founder)inDr. Ci Chu(Chief Discovery Officer)DBDr. Bo Wang(Chief AI Scientist)Dr. Ian McCaffery(SVP, Translational Science and Early Clinical Development)Bob Nelsen(Founder)

Co-investorsARARCH Venture PartnersBRBreyer CapitalDEDeviation CapitalF-F-Prime CapitalFOForesite CapitalMEMenlo Ventures+5 more

XyloCor Therapeutics develops gene therapies for advanced coronary artery disease and cardiac damage.

BiotechHealthtechMedical DevicesMalvern, US

RCRonald Crystal(Founder and Advisor (Board Observer))TRTodd Rosengart(Founder; Board Observer)JTJohn Tucker(President and CEO)Albert Gianchetti(Executive Officer, Director)

BoardGBGlenn Batchelder(Director)inJames Cohen(Director)

Co-investorsFOFountain Healthcare PartnersLULumira VenturesJEJeito CapitalSOSofinnova Ventures