Fundraising FoxPittsburgh · Seed–Growth · 11 people tracked
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Investment thesis
UPMC Enterprises functions as the corporate venture and commercialization arm of UPMC, a large health care provider and insurer. Leveraging the clinical expertise of thousands of UPMC physicians and payer insights from the UPMC Health Plan, the firm identifies emerging health care trends and supports scientific breakthroughs that can be translated into improvements in medical care and technology. It also partners with institutions such as Carnegie Mellon University and the University of Pittsburgh (through PHDA) and runs the Center for Connected Medicine to advance digital health. Its goal is to transform ideas into viable businesses that deliver value to patients and the broader health care system.
Source: firm website, verified Oct 17, 2026.
Team · 11 people
from the firm's website
What they invest in
from 21 of 27 portfolio companiesHealthtech ×16Digital Health ×13AI & Machine Learning ×10Biotech ×8Medical Devices ×8Data & Infrastructure ×3Deep Tech ×2Enterprise Software ×2
HQs:United States×17
Investments · 27 tracked
founders shown can be your intro pathBy year:2025 · 12024 · 22023 · 12022 · 22021 · 22019 · 19 dated
Generian Pharmaceuticals is a preclinical biotechnology company developing orally available small molecule therapeutics for diseases with high unmet need, particularly conditions currently treated by biologics.
BiotechDeep TechLongevityPittsburgh, US
Bill Chen(Vice President, Drug Discovery & Co-Founder)Yuan Liu(Vice President, Biology & Co-Founder)inHank Safferstein(Chief Executive Officer)inPo-Shun Lee(Chief Medical Officer)inAlan Barber(Chief Financial Officer)Beibei Chen(Director)
Novasenta is a biotechnology company that uses single-cell analysis of human tissue samples combined with computational biology to discover novel therapeutic targets and develop treatments for immune-mediated diseases and cancer.
AI & Machine LearningBiotechHealthtechPittsburgh, US
Greg M. Delgoffe(Co-Founder & Director)Robert Ferris(Co-Founder & Scientific Advisor)Dario A. A. Vignali(Co-Founder)Matthias Kleinz(Director)Mani Mohindru(Executive Officer, Director)
BoardJeanne Cunicelli(Director)
RxAnte provides tech-enabled, value-based pharmacy care management, including analytics and quality-improvement tools plus high-touch pharmacy services, for health plans, providers, and pharmacies.
AI & Machine LearningData & InfrastructureDigital HealthHealthtechPortland, US
Josh Benner(Co-Founder & CEO)inLisa Jurinka(SVP, General Counsel)inNiteesh Choudhry(SVP, Chief Medical and Science Officer)inAmie Joyce(SVP, Head of Technology Operations)inPatrick Baker(SVP, General Manager at Mosaic Pharmacy Service)Jessica Frank(SVP, Client Success)in
Co-investorsPrimus CapitalFirst Trust Capital PartnersAberdare Ventures
sovaSage develops technology that optimizes the CPAP mask-fitting process for sleep apnea patients.
AI & Machine LearningHealthtechMedical DevicesCentral City, US
William Kaigler(Executive Officer, Director)inDavid Mawhinney(Director)Christian Kebekus(Executive Officer, Director)Julie Kaigler(Executive Officer)
Co-investors412 Venture FundLife Sciences Greenhouse InvestmentsRiverfront Ventures, LLC
Arkos Health partners with payers to transform provider networks and transition to value-based care models.
Digital HealthEnterprise SoftwareHealthtech
Tanner(CEO)Jerry Williamson(Executive Director of the Board & Chief Strategy Officer)
Co-investorsPartners for Growth
Developing innovative gene therapies for retinal diseases and rare ophthalmic conditions.
BrainCheck offers a platform for cognitive assessment and care planning, centered on an FDA-registered Class II digital cognitive assessment plus over 30 clinical evaluation tools that integrate into clinical workflows and EHR systems like Epic and athenahealth.
Digital HealthHealthtechMedical DevicesSaaSHouston, US
Yael Katz(Executive Officer, Director)inDavid Eagleman(Executive Officer, Director)inAndrew Chen(Founder)in
Co-investorsBlue Hour VenturesGOOSE CapitalNext Coast VenturesNueterra CapitalS3 VenturesTensility Venture Partners+1 more
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AI & Machine LearningDigital HealthHealthtechPittsburgh, US
Gilan El Saadawi(Executive Officer, Director, Promoter)Betsy Castillo(Head of Clinical Data Abstraction)inMichael Finke(Director)Brenton Burns(Director)Scot Stevens(Director)Aaron Brauser(Executive Officer, Director, Promoter)
Co-investorsAsset Management CompanyCU Healthcare Innovation FundFrist Cressey VenturesHealthy VenturesKatalyst VenturesKatalyst.Ventures+11 more
Cerevance develops precision novel therapeutics for central nervous system disorders, particularly neurodegenerative diseases, using its proprietary NETSseq platform and machine learning to identify targets from an extensive collection of human brain tissue samples.
AI & Machine LearningBiotechDeep TechHealthtechMedical DevicesBoston, US
Craig Thompson(Chief Executive Officer)inSagar Vaidya(Chief Medical Officer)inCarrie Ann Cook(Chief Business Officer)Mark Carlton(Chief Scientific Officer)inOttavio V. Vitolo(Chief Medical Officer)in
Co-investorsDementia Discovery FundForesite CapitalGV (Google Ventures)SV Life SciencesDementia DiscoveryDolby Family Ventures+4 more
BiotechPittsburgh, US
Michael Hoerres(Executive Officer, Director)
BoardJames Peters(Director)Steve Grenfell(Director)Paul Schmitt(Director)Noel Doheny(Director)
Co-investorsIllumina VenturesBen Franklin Technology Partners of Northeastern PennsylvaniaPittsburgh Life Sciences Greenhouse
Clearsense operates the 1Clearsense Platform, a healthcare data lakehouse that unifies and manages disparate data for health systems and presents it in simplified, actionable views.
AI & Machine LearningData & InfrastructureDigital HealthHealthtechSaaSJacksonville, US
Ken Misch(Chief Financial Officer and Chief Operating Officer)inJason Rose(Chief Executive Officer)inMatt Henderson(Chief Compliance Officer and General Counsel)Jonathan Cook(Chief Technology Officer)inWirick Glenn(Chief Commercial Officer)Eugene Scheurer(Executive Officer, Director)
Co-investorsHealth Catalyst CapitalHealthQuest CapitalKairos Venture Investments, Llc
Elektra Health is a virtual menopause care platform combining telemedicine, coaching, education and community.
Alessandra Henderson(Founder)inJannine Versi(Founder)
Co-investorsChloe CapitalCity LightEverywhere VenturesFlare Capital PartnersKaya VenturesNextblue+5 more
Hashed Health is a venture firm that combines healthcare operators, technologists, and entrepreneurs to develop practical businesses addressing complex healthcare challenges.
Digital HealthEnterprise SoftwareHealthtech
Raelyn Wilson(Founder & CEO, Peer Supply)inLeigh McCormack(Founder & CEO, Platypus)inMolly Moore(Founder & CEO, Bramble Health (acquired))inChris Gormley(Founder & CEO, Sub Pop Health)inAnthony Begando(Founder & CEO, ProCredEx)inKevin McGovern(Founder & CEO, Venturous)in
Co-investorsMartin VenturesFirst Trust Capital PartnersWhistler Capital Partners
ID Connect provides access to specialized infectious disease (ID) expertise through a team of clinicians and technology staff, using telemedicine to improve patient care and outcomes.
Digital HealthHealthtechMedical DevicesCranberry Township, US
John Mellors(Co-founder)Riaan Erwee(Executive Officer)Tami Minnier(Director)Rima Abdel-Massih(Co-founder)Brenton Burns(Director)Jonathan Phillips(Director)
Co-investorsMerck Global Health Innovation FundMSD Global Health Innovation FundFirst Trust Capital Partners
Mozart Therapeutics develops protein therapeutics focused on immunology and oncology treatments.
BiotechMedical Devices
Mark Davis(Scientific Co-Founder)K. Christopher Garcia(Scientific Co-Founder)Calvin Kuo(Scientific Co-Founder)Katie Fanning(President & Chief Executive Officer)in
Co-investorsARCH Venture PartnersJDRF T1D FundMRL Ventures FundOno Venture Investment, Inc.Pfizer Venture InvestmentsSofinnova Partners+7 more
Pip Care provides a service combining AI monitoring and human navigators to guide surgical patients through the pre-operative window (roughly 96 to 48 hours before surgery), identifying risk and intervening to prevent last-minute cancellations.
AI & Machine LearningDigital HealthHealthtechFlagler Beach, US
KEITH PENDERGRAST(Executive Officer)inKATHY KALUHIOKALANI(Executive Officer, Director)Brett Shaheen(Executive Officer, Director)Nathan Marinoff(Executive Officer)
BoardCURTIS STRATMAN(Director)RACHEL - KERN(Director)in
Co-investors412 Venture FundA1 Health Ventures
Precede Biosciences develops a blood-based diagnostic platform that profiles gene expression from cell-free DNA to reveal disease biology at the transcriptional level for drug developers and clinical trials.
AI & Machine LearningBiotechDigital HealthBoston, US
Rehan Verjee(Co-Founder, Chief Executive Officer, Board Director)inSylvan Baca(Co-Founder; Assistant Professor of Medicine, Dana-Farber Cancer Institute)inToni Choueiri(Co-Founder; Director, Lank Center for GU Oncology, Dana-Farber Cancer Institute)Matthew Freedman(Co-Founder; Professor of Medicine, Dana-Farber Cancer Institute)
Co-investors5AM VenturesIllumina VenturesOUP (Osage University Partners)AlexandriaLilly Asia VenturesS28 Capital
Redesign Health is a venture capital and applied technology platform that builds and invests in next-generation healthcare companies using AI-native strategies.
AI & Machine LearningDigital HealthHealthtech
Co-investorsCVS Health VenturesDeclaration PartnersForerunner VenturesForesite CapitalGaingelsGeneral Catalyst+4 more
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Sempre Health provides digital health solutions focused on patient engagement and outcomes management for the healthcare industry.
Digital HealthHealthtechSan Francisco, US
Anurati Mathur(Founder)inSwaraj Banerjee(Founder)inRobert S. Spalding(Executive Officer, Director)Ashley Carroll(Director)
BoardJenny Abramson(Director)inTyler Rowe(Director)
Co-investorsBlue Venture FundsCencora VenturesCerity Partners VenturesEcho Health VenturesLifeforce CapitalRethink Impact+4 more
Spark Pediatrics operates medical daycares providing advanced medical care and therapies for children with complex medical needs in a social setting, serving families across multiple locations in Florida.
Digital HealthHealthtechMedical DevicesFlorida, US
Jeff Soffen(Chief Executive Officer)inMelissa Lacy(Chief Nursing Officer)in
Co-investorsTown Hall VenturesCity LightFlorida Opportunity FundK2 HealthVentures
Sudo Biosciences develops small molecule therapeutics for neurological and immune-mediated inflammatory conditions.
BiotechHealthtechMedical DevicesMenlo Park, US
Jim Bristol(Director)Daniel Estes(Director)inScott Byrd(Executive Officer, Director)in
Co-investorsFrazier Life SciencesMonograph Capital PartnersPICUS CAPITALSanofi VenturesSV Health InvestorsDementia Discovery Fund+3 more
Offering a practice education solution for NPs, PAs, and the facilities that employ them.
Ahavi is a real-world data platform that provides primary source-verified, de-identified health care data and analytics tools to researchers, scientists, and AI developers.
AI & Machine LearningData & InfrastructureDigital Health
Werewolf Therapeutics is a biotechnology company developing immunotherapy treatments for cancer.
BiotechHealthtechMedical DevicesWatertown, US
Daniel J. Hicklin(Founder, President, Chief Executive Officer, and Board member)Luke Evnin(Co-founder, Board member (Chairman))inDavid Cordo(Executive Officer)Alon Lazarus(Director)
BoardChristoph Westphal(Director)Briggs Morrison(Director)in
Co-investorsDC Investment PartnersK2 HealthVenturesLongwood FundMPM BioImpactRA CapitalTaiho Ventures, LLC
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Interra HealthMyUPMCParlaiQ
Portfolio news
latest coverage across their companies
Spark Pediatrics · thehealthcareinvestor.com · Aug 26, 2026
BrainCheck · finsmes.com · Feb 27, 2026
RxAnte · finsmes.com · Jan 13, 2026
Frequently asked questions
- How many investments has UPMC Enterprises made?
- UPMC Enterprises has 27 tracked investments, including 1 dated in the last 24 months.
- What stage does UPMC Enterprises invest at?
- UPMC Enterprises invests at the Seed, Growth stages.
- What sectors does UPMC Enterprises focus on?
- UPMC Enterprises focuses on Biotech, Digital Health, Healthtech.
- Where is UPMC Enterprises located?
- UPMC Enterprises is headquartered in Pittsburgh, US.
- Does UPMC Enterprises lead rounds?
- UPMC Enterprises has led 5 of the 25 rounds where its role is on record.
- Who does UPMC Enterprises co-invest with?
- UPMC Enterprises most often shares deals with Chloe Capital, Flare Capital Partners, MPM BioImpact, among 18 tracked co-investors.