First Spark Ventures, Llc
Venture capitalMenlo Park · Pre-Seed–Series A
Investment thesis
First Spark Ventures invests in deep tech startups that can leverage breakthroughs in advanced computation, AI-based computational biology, and physical systems with software-like scaling potential. The firm targets companies with stellar teams, large accessible markets, and sustainable technological differentiation across three key areas: advanced compute that increases productivity and innovation, digital biology and therapeutics that improve human health spans through personalized medicine, and cyberphysical systems that enhance productivity and safety through scalable automation and intelligence.
Source: firm website, verified Jul 21, 2026.
What they invest in
from 3 of 3 portfolio companiesAI & Machine Learning ×3Medical Devices ×2Biotech ×1Deep Tech ×1Developer Tools ×1Hardware ×1Healthtech ×1
HQs:United States×1
Investments · 3 tracked
founders shown can be your intro pathFIGUR8 is an FDA-registered platform that provides objective, actionable insights for musculoskeletal health diagnosis and treatment. The platform originated from collaboration between MIT scientists, Massachusetts General Hospital, and the Boston Red Sox, and is now adapted for use across any point of care.
AI & Machine LearningHardwareHealthtechMedical DevicesBoston, US
Nan-Wei Gong(CEO and Founder)
Inworld AI provides a full-duplex audio streaming platform that enables real-time conversational AI interactions with intelligent turn-taking, function calling, and multi-model routing capabilities for developers building conversational applications.
AI & Machine LearningDeveloper Tools
Unnatural Products is a drug discovery platform company that develops synthetic macrocycles to target previously undruggable disease targets. The company focuses on expanding its pipeline of novel therapeutic medicines by leveraging macrocycle chemistry and pharmacokinetics.
AI & Machine LearningBiotechDeep TechMedical Devices
Cameron Pye(Co-Founder & CEO)Joshua Schwochert(Co-Founder & CSO)
Frequently asked questions
- What stage does First Spark Ventures, Llc invest at?
- First Spark Ventures, Llc invests at the Pre-Seed, Seed, Series A stages.
- What sectors does First Spark Ventures, Llc focus on?
- First Spark Ventures, Llc focuses on AI & Machine Learning, Biotech, Cybersecurity, Deep Tech, Robotics.
- Where is First Spark Ventures, Llc located?
- First Spark Ventures, Llc is headquartered in Menlo Park, US.
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