/Companies

Sensible Biotechnologies

YC S21

Oxford, GB · Founded 2021 · Delaware corporation · 24 employees · 19 known investors

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Sensible Biotechnologies develops a cell-based mRNA design and manufacturing platform that produces pure, low immunogenicity mRNA therapeutics for drug development. The platform addresses limitations of synthetic mRNA by enabling design-based biology approaches.

Also known as Genbiotics

Founders & leadership· Y Combinator alumni (S21)

Sensible Biotechnologies was founded in 2021 by Miroslav Gasparek and Marian Kupculak.

MGMiroslav Gasparek
Miroslav GasparekCEO and Co-FounderHe studied bioengineering at Imperial College London and engineering at Oxford, and has worked on Slovak biosecurity policy development.
MKMarian Kupculak
Marian KupculakCo-founder · Chief Science OfficerMarian Kupculak holds a PhD in Biochemistry from the University of Oxford and has over 9 years of experience in biochemistry and molecular biology, with expertise in cellular engineering and downstream processing. He is co-founder and Chief Scientific Officer of Sensible Biotechnologies, which develops manufacturing platforms for mRNA production.

Board

VG
Vishal GulatiBoard director
JS
Joel SchoppigBoard director

Investors · 19

KAYAlisted by KAYAPrague · $108K – $3.2M

How we know: KAYA's portfolio page · the VCSheet dataset · Y Combinator's founder network · Not right? Tell us

Amino CollectivereportedBerlin · $216K – $1.6M

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AternusreportedTřinec

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BackedreportedLondon · $500K – $5M

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BlueYard CapitalreportedBerlin · $500K – $5M

How we know: a partner's Signal profile · funding news · the VCSheet dataset · open dataset · 5k.vc investor directory · Y Combinator's founder network · Not right? Tell us

Isomer CapitalreportedLondon

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Jolt CapitalreportedParis · $11M – $55M

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Loop VCreported

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Possible VenturesreportedMunich · $100K – $5M

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Power E HoldingsreportedHouston

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Tola CapitalreportedSeattle · $1M – $15M

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Reported raises · per SEC filings

Form D private placements

$15.3M disclosed across 2 rounds · 2023–2026

▶$13.5MraisedSep 2026 · 15 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Miroslav GasparekExecutive Officer, Director
  • Marian KupculakExecutive Officer, Director
  • Joel SchoppigDirector
  • Vishal GulatiDirector
Offering amount
$15M
Amount sold
$13.5M
Proceeds to insiders
$200K
First sale
Aug 2026
Incorporated
Corporation, Delaware, 2021
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$1.8MraisedFeb 2023 · 18 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Marian KupculakExecutive Officer, Director
  • Miroslav GasparekExecutive Officer, Director
Offering amount
$3M
Amount sold
$1.8M
Proceeds to insiders
$100K
First sale
Feb 2023
Incorporated
Corporation, Delaware, 2021
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

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TareBioTareBio operates a platform for developing personalized and population-level vaccines against cancer and infectious diseases by analyzing immune cells already responding to a disease and reverse-engineering the antigens that activate them. The company works in the biotechnology and vaccine development space.
Senti BiosciencesSenti Bio develops cell and gene therapies for cancer and difficult-to-treat diseases using synthetic biology and engineered Gene Circuits to enhance precision, control, and selectivity in targeting tumor cells. The company is a clinical-stage biotech firm leveraging proprietary platform technology across multiple cell types and modalities.
Evolvere BioSciencesEvolvere BioSciences develops antibiotics using computational models and evolutionary data to target pathogenic bacteria while preserving beneficial microbes, designed to resist the development of bacterial resistance.
AlixiaAlixia develops therapeutics targeting tumor ecosystems to address cancer drug resistance and age-related diseases. The company integrates biology, biophysics, and computational chemistry to design compounds that disrupt metabolic and inflammatory triggers in multiple cell types within the tumor microenvironment.
Engage BioEngageBio develops DNA-based medicines using proprietary non-viral delivery technology to achieve extended therapeutic expression from a single dose with low manufacturing complexity.
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Companies working in the same space as Sensible Biotechnologies.

Legal entities · 1

corporate structure
Sensible Biotechnologies, Inc.

Companies House · registry record

View on Companies House ↗
Registered name
SENSIBLE BIOTECHNOLOGIES LIMITED
Company number
14628427
Status
Active
Company type
Private limited company
Incorporated
31 Jan 2023
Registered office
3rd Floor 1 Ashley Road, Altrincham, Cheshire, WA14 2DT
Nature of business (SIC)
72110 — Research and experimental development on biotechnology72190 — Other research and experimental development on natural sciences and engineering
Accounts
last made up to 31 Dec 2024 · next due 30 Sept 2026
Confirmation statement
last made up to 30 Jan 2026 · next due 13 Feb 2027

Current officers · 2

  • Miroslav Gasparek — director, appointed 31 Jan 2023
  • Marian Kupculak — director, appointed 31 Jan 2023

Source: Companies House public register · retrieved 24 Jul 2026. Contains public sector information licensed under the Open Government Licence v3.0.

In the news

Frequently asked questions

What does Sensible Biotechnologies do?
Sensible Biotechnologies develops a cell-based mRNA design and manufacturing platform that produces pure, low immunogenicity mRNA therapeutics for drug development. The platform addresses limitations of synthetic mRNA by enabling design-based biology approaches.
Who founded Sensible Biotechnologies?
Sensible Biotechnologies was founded by Miroslav Gasparek, Marian Kupculak in 2021.
Who are Sensible Biotechnologies's investors?
Sensible Biotechnologies's investors include Civilization Ventures Management, Llc, In-Q-Tel, KAYA, Recode Ventures, Traun Ventures, Y Combinator, ZAKA VC, Amino Collective and 11 more.
How much funding has Sensible Biotechnologies raised?
Sensible Biotechnologies has disclosed $15.3M raised across 2 rounds.
Where is Sensible Biotechnologies headquartered?
Sensible Biotechnologies is headquartered in Oxford, GB.