/Investor DB

Lightstone Ventures — 2025 Investments

6 investments dated 2025 · listed companies and verified rows first · show all

Shoulder Innovationsshoulderinnovations.cominNYSE: SIMar 2025

Shoulder Innovations develops InSet® glenoid technology for shoulder joint implants that reduce the rocking horse effect and provide mechanical stability, serving patients with severe shoulder arthritis.

HardwareHealthtechMedical DevicesNorthern California, US

Robert Ball(CEO & Executive Chairman)Matthew Ahearn(Chief Operating Officer)inJeff Points(Executive Officer)inDon Running(Manager and Chief Executive Officer)Jeff Ondrla(Chief Technology Officer)David L. Blue(Chief Customer Experience Officer)in

Board seatMike Carusi· per SEC Form D

Co-investorsAlumni VenturesAPERTURE Venture PartnersArboretum VenturesGenesis Innovation GroupGlobal BrainInvest Michigan+3 more

PsiTherapsithera.comin𝕏Series A · Dec 2025 · $48M✓ verified

PsiThera is a biotechnology company using computational and physics-based methods—including quantum mechanics, molecular dynamics, machine learning, and simulation—for mechanism-driven drug design and discovery.

AI & Machine LearningBiotechDeep Tech

Co-investorsSamsara BioCapital

Apreo Healthapreohealth.cominAug 2025

Apreo Health develops a bronchoscopic treatment for severe emphysema using a self-expanding airway scaffold designed to reduce trapped air and improve lung function.

BiotechHealthtechMedical DevicesMenlo Park, US

Karun Durgam Naga(Executive Officer, Director)

BoardHanson S. Gifford III(Director)Zack Scott(Director)inDrew Field(Director)inDennis McWilliams(Director)in

Board seatHanson S. Gifford, IIIMichael A. Carusi· per SEC Form D

Co-investorsF-Prime CapitalIntuitive VenturesNorwest Venture PartnersStar51 Capital

Reprieve Cardiovascularreprievecardio.comSeries B · May 2025 · $61M

Reprieve Cardiovascular develops a decongestion management system that uses real-time patient data to guide and personalize diuretic therapy for fluid removal in heart failure patients.

Digital HealthHealthtechMedical DevicesMilford, US

Tony Fields(Executive Officer)Adam Bartnik(Executive Officer)inMark Pacyna(Executive Officer, Director)inJim Dillon(Executive Officer, Director)Hanson S. Gifford III(Director)Gregory W Mann(Executive Officer)

Board seatHanson S. Gifford, III· per SEC Form D

Co-investorsArboretum VenturesRex Health VenturesDeerfield Management CompanyGenesis Venture CapitalSante Ventures

Trotana Therapeuticstrotana.comSeries A · Feb 2025 · $53M

San Diego biotech founded in 2019 developing oral anti-inflammatory small molecules targeting RNA binding proteins.

Co-investorsARCH Venture PartnersMedical Excellence CapitalCanaan Partners

Urotronicurotronic.comin𝕏Aug 2025 · $80M

Urotronic develops drug-coated balloons for interventional urology, including the Optilume products for treating benign prostatic hyperplasia (BPH) and urethral strictures.

HealthtechMedical DevicesPlymouth, US

Junfeng Wang(Director)David Perry(Executive Officer, Director)Tan Ching(Director)Hui Hu(Director, Promoter)Lixiao Wang(Director, Promoter)Doug Kohrs(Director)

Co-investorsHM Venture PartnersEnterprise IrelandGilde HealthcareIreland Strategic Investment FundLegend CapitalMVM Life Science Partners+1 more

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.