645 Ventures
New York · Pre-Seed–Seed · 18 people tracked
Investment thesis
645 Ventures focuses on backing exceptional founders who demonstrate four key traits: authenticity in motivation to solve real problems, earned secrets derived from deep domain expertise or lived experience, obsessive focus on solving specific problems, and non-consensus thinking to identify opportunities the market hasn't yet recognized. The firm invests at the earliest stages of company building and provides hands-on support beyond capital, including go-to-market strategy, advisor networks, distribution partnerships, and fundraising guidance.
Source: firm website, verified Jul 20, 2026.
Team · 18 people
from the firm's websiteWhat they invest in
from 14 of 125 portfolio companiesEnterprise Software ×9SaaS ×8AI & Machine Learning ×5Consumer ×2Cybersecurity ×2Developer Tools ×2Fintech ×2FoodTech ×2
HQs:United States×13Mexico×1
Investments · showing 60 of 125
founders shown can be your intro pathLunchbox is a digital commerce platform for enterprise restaurants that unifies ordering, catering, loyalty, and marketing functions. The platform helps large restaurant brands streamline operations and build guest relationships through integrated technology.
Enterprise SoftwareFoodTechRetail TechSaaS
Nabeel Alamgir(Executive Chairman & Founder)James Walker(CEO)
Upside provides end-to-end housing stabilization services for individuals experiencing housing instability within healthcare settings, serving health plans, employers, and their members across Medicaid, Medicare, and employer coverage. The company coordinates case management, local navigation, and community partnerships to resolve complex housing situations and improve health outcomes.
Enterprise SoftwareHealthtechSaaSSocialWellness & FitnessFort Lauderdale, US
Jake(CEO)Peter(Co-founder)
Causely builds autonomous reliability software that helps engineering teams prevent incidents and reduce troubleshooting time in cloud-native environments. The platform applies causal analysis to provide proactive service reliability for distributed systems.
AI & Machine LearningCloud ComputingDeveloper ToolsEnterprise Software
Dr. Shmuel Kliger(Founder)
DeepSource provides developer tools for code quality and security. The platform serves developers and engineering teams at startups and large enterprises.
AI & Machine LearningCybersecurityDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US
Sanket Saurav(Co-founder & CEO)inJai Pradeesh(Co-founder & President)in
Genially is a platform for creating interactive and animated content, with built-in AI tools for content generation. It serves professionals across education, marketing, corporate training, and communications who need to produce engaging visual presentations and learning materials.
Creator EconomyEdTechSaaS
An online marketplace that connects specialty food producers and artisans with nationwide customers, handling the logistics of shipping handmade and regionally distinctive food products.
ConsumerFoodTechMarketplacesNew York City, US
Joe Ariel(Founder/CEO)inJoel Gillman(Founder/Vice President of Engineering)inVanessa Torrivilla(Founder/CPO)in
Board seats · per SEC filings · 6
what is this? ⓘ$500K raise · filed Jan 2026 · via Aaron D Holiday, Aaron Holiday
$12M raise · filed Sep 2025 · via Nnamdi Okike
$10.9M raise · filed Sep 2024 · via Aaron Holiday
$7M raise · filed May 2024 · via Nnamdi Okike
$30M raise · filed Aug 2021 · via Nnamdi Okike
$20.3M raise · filed Oct 2020 · via Nnamdi Okike
Inferred from directors named on each company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does 645 Ventures invest at?
- 645 Ventures invests at the Pre-Seed, Seed stages.
- What sectors does 645 Ventures focus on?
- 645 Ventures focuses on Sector Agnostic.
- Where is 645 Ventures located?
- 645 Ventures is headquartered in New York, US.
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