645 Ventures
Venture capitalNew York · Pre-Seed–Series B · 23 people tracked
Also known as 645 VENTURES MANAGEMENT, LLC
Find your way into 645 Ventures
5,720 people in our graph share verified history with the 645 Ventures team — schools, employers, funds. One of them is your warm intro.
Investment thesis
645 Ventures invests in exceptional founders at the earliest stages, seeking companies that are pre-product, pre-revenue, and pre-consensus. The firm evaluates founders against four traits: purity of motivation (authentic drive to solve a problem), an earned secret (non-obvious market insight from deep expertise or contrarian research), obsessive problem-solving focus, and non-consensus thinking. Beyond capital, the firm actively supports portfolio companies through go-to-market strategy, fundraising guidance, valuation and term negotiation help, and connecting founders with advisors, distribution partners, and other key stakeholders. It concentrates on several areas of deep domain experience across the technology landscape.
Source: firm website, verified Sep 15, 2026.
Team · 23 people
from the firm's website & curated & public directoriesFounder mafia
3 people who came through 645 Ventures went on to found or lead other companies.
What they invest in
from 76 of 154 portfolio companiesSaaS ×40AI & Machine Learning ×36Enterprise Software ×29Fintech ×14Consumer ×9Cybersecurity ×8Data & Infrastructure ×8Healthtech ×8
HQs:United States×56United Arab Emirates×1Canada×1Switzerland×1Denmark×1United Kingdom×1
Who they back
founder profiles across 34 portfolio companiesFounding team size:solo founder×102 founders×113 founders×84+ founders×5
Where their founders studiedfrom 59 founders with education data
Princeton University ×4Arizona State University ×2Brown University ×2Duke University ×2Harvard Business School ×2Harvard University ×2LeapYear ×2The University of North Carolina at Chapel Hill ×2
What their founders studiedfrom 53 founders with field-of-study data
Computer Science ×20Engineering ×12Economics ×7Business & Management ×6Finance & Accounting ×3Mathematics & Statistics ×3Humanities ×2Physics ×2
Where their founders worked beforefrom 62 founders with career history
Goldman Sachs ×3HelloSign ×3Nitra ×3OpenHands AI ×3Amdocs ×2Apple ×2Carnegie Mellon University ×2Dropbox ×2
Accelerator rootsportfolio companies that came through a program
2 founders hold a PhD · 15 hold an MBA (of 58 with degree data)
Investments · showing 145 of 154
founders shown can be your intro pathBy year:2026 · 62025 · 72024 · 62023 · 62022 · 42021 · 52020 · 42019 · 22016 · 141 dated
FiscalNote provides AI-powered software that aggregates and interprets legislative and regulatory data to help organizations track and influence policy outcomes.
AI & Machine LearningData & InfrastructureGovTechSaaSWashington, US
Tim Hwang(Co-founder)inGerald Yao(Co-founder)inJonathan Chen(Co-founder)inPaul Donnell(Chief Accounting Officer)inJon Slabaugh(CFO and Senior VP of Corporate Development)inRichard Henderson(Executive Officer)in
PartnerAaron Holiday· led
Co-investorsChaac VenturesConversion CapitalDorm RoomEastward Capital PartnersFitz Gate VenturesGPO Fund+12 more
Lunchbox is a digital commerce platform for enterprise restaurants that unifies ordering, catering, loyalty, and marketing functions.
Enterprise SoftwareFoodTechRetail TechSaaSNew York, US
Nabeel Alamgir(Executive Chairman & Founder)inAndrew Boryk(Founder)inJames Walker(CEO)in
Board seatNnamdi Okike· per SEC Form D
Co-investorsPrimary Venture Partners1982 VenturesBeyond CapitalCoatue ManagementEvolution VC PartnersFrontline Ventures+4 more
Upside provides end-to-end housing stabilization services for individuals experiencing housing instability within healthcare settings, serving health plans, employers, and their members across Medicaid, Medicare, and employer coverage.
Enterprise SoftwareHealthtechSaaSSocialWellness & FitnessFort Lauderdale, US
Jake(CEO)inPeter Badgley(Executive Officer, Director)inJacob Rothstein(Executive Officer, Director)
Board seatAaron Holiday· per SEC Form D
Co-investorsEquitage Ventures, L.L.C.Flare Capital PartnersTechstars
Meridian is a CRM and data platform for venture capital and investment firms that centralizes deal history, automates workflow logging, and enriches records with a bundled database of 26 million company records and verified contacts.
AI & Machine LearningFintechSaaS
Alex Sen(Founder & CEO)inAlex Zagoro(Chief Technology Officer)in
Co-investorsDniproAndreessen Horowitz
Stake is a digital real estate investment platform that enables global property ownership by providing access to curated real estate funds and fractional ownership opportunities.
AI & Machine LearningB2B MarketplacesDeveloper ToolsFintechMedia & EntertainmentMobility & TransportationPropTechSaaSDubai, AE
Vytis Šliažas(CEO and co-founder)Manar Mahmassani(Co-Founder and Co-CEO)Rami Tabbara(Co-Founder and Co-CEO)
Co-investors359 CapitalCarya Venture PartnersEmirates NBDHF0Superhero CapitalWa'ed Ventures+1 more
Clerq is a payment platform that lets businesses accept guaranteed bank-account payments from customers in store or online, reducing card processing fees and chargeback risk.
FintechSaaSNew York, US
Truett Dwyer(Executive Officer, Director)inBenjamin Markowitz(Executive Officer, Director)
BoardAdam Nelson(Director)
Board seatNnamdi Okike· per SEC Form D
Co-investorsCoalition OperatorsFikaFirstMark CapitalCommerce VenturesDash FundFika Ventures
ECL provides non-dilutive, revenue-based financing to SaaS and AI companies with recurring revenue, using AI-assisted underwriting to make cross-border funding decisions quickly.
AI & Machine LearningFintechSaaSNew York, US
KAUSTAV DAS(Executive Officer, Director)inMANISH ARORA(Director)in
BoardSANDEEP PATIL(Director)in
Board seatAaron Holiday· per SEC Form D
Co-investorsEudemian VenturesEverywhere VenturesLorimer VenturesQED InvestorsTwo Culture CapitalThe Fund
Mandolin provides AI agents that automate back-office workflows for specialty drug administration, including patient intake, benefits verification, prior authorizations, and revenue cycle management for infusion centers and clinical practices.
AI & Machine LearningEnterprise SoftwareHealthtechSan Francisco, US
Mary Kay Huse(Executive Officer, Director)Will Yin(CEO & Co-Founder)inRohit Rustagi(Co-Founder & COO)in
BoardMike Fitzgerald(Director)inEric Tobias(Director)inScott D. Dorsey(Director)in
Board seatNnamdi Okike· per SEC Form D
Co-investorsGreylock PartnersSignalFireSV AngelTimelessFoundryHigh Alpha+1 more
RentSpree is a digital platform that simplifies the home rental process by streamlining tenant screening, applications, and rent payments for renters, agents, and landlords.
MarketplacesPropTechSaaSLos Angeles, US
Michael Lucarelli(CEO & Co-founder)inPaul Sirisuphang(COO & Co-founder)Ekabutr Sirisuphang(Director)in
Board seatNnamdi Okike· per SEC Form D
Co-investorsAmplify.LAKube VCRally Ventures Management, LlcVesta VenturesGreen Visor CapitalTenOneTen Ventures
SkydropX provides shipping automation software for e-commerce and retail businesses in Mexico, handling label generation, tracking, delivery time estimation, and return management across the fulfillment process.
Enterprise SoftwareLogistics & Supply ChainMarketplacesSaaSMonterrey, MX
Tavo Zambrano(Founder/CEO)inArmando Solbes(Founder)inLuis Garza Sada(Executive Officer, Director)Arnoldo Collin(Executive Officer, Director)
BoardWeston WAMP(Director)
Board seatAaron Holiday· per SEC Form D
Co-investorsSierra VenturesY CombinatorFJ Labs
Uptiq builds pre-built, domain-trained AI agents that automate operational work in banking and lending—covering prospecting, onboarding, underwriting, credit decisioning, risk monitoring, and client engagement.
AI & Machine LearningEnterprise SoftwareFintechMckinney, US
Snehal Fulzele(Executive Officer, Director)inGanapathi Palanipandian(Director)
BoardMichael Walsh(Director)
Board seatNnamdi Okike· per SEC Form D
Co-investorsCota CapitalCurql Collective, LLCEPIC VENTURESEvolution VenturesHourglass Venture PartnersSilverton Partners+6 more
Alex is a recruitment automation platform that conducts candidate screening, interviews, and scoring using standardized questions and objective criteria.
AI & Machine LearningEnterprise SoftwareHR TechSaaSSan Francisco, US
Aaron Wang(Founder)inJohn Rytel(Founder)in
Co-investorsPeak XV PartnersY Combinator1984 Ventures Management, LlcHOF CapitalUncorrelated Ventures
All Hands develops OpenHands, an open-source, model-agnostic platform for building and running AI coding agents, providing the interface, automation, and control layer to scale from a single local agent to an organization-wide system.
AI & Machine LearningCloud ComputingDeveloper ToolsEnterprise Software
Robert Brennan(CEO)inGraham Neubig(Chief Scientist)inXingyao Wang(Chief AI Officer)inBen Solari(CRO)in
Co-investorsBetaworksFujitsu VenturesPillar VCMenloMenlo Ventures
Alma Security provides runtime application security that monitors applications in real time and captures context-specific telemetry across APIs, microservices, databases, dataflow, and identities.
CybersecurityDeveloper ToolsSaaS
Andrena is a wireless Internet service provider that delivers high-speed connectivity to multi-tenant buildings and households using wireless technology beamed to building roofs, then distributed wirelessly to units.
CleantechCloud ComputingNew Jersey, US
Neil Chatterjee(Founder)inJames Smits(Founder)in
Co-investorsAfore CapitalBollinger Investment GroupCalm VenturesCastle Island VenturesChaos VenturesChapter One+7 more
AptDeco is an online marketplace where users buy and sell used furniture with integrated delivery services.
Circular EconomyConsumerE-commerceLogistics & Supply ChainMarketplacesNew York City, US
Reham Fagiri(Founder/CEO)inKalam Dennis(Founder)inkalam dennis(Founder)in
BoardBrett Topche(Director)in
Co-investorsComcast VenturesFJ LabsGreat Oaks Venture CapitalHearstLabRed & Blue VenturesSandalphon Capital+2 more
Arbor provides a platform that helps households access renewable electricity at lower costs while reducing energy-related complexity.
ConsumerEnergySaaS
Co-investorsCity LightFirst Round CapitalFJ LabsLowercarbon CapitalObvious VenturesThird Sphere+3 more
Arbor develops power systems intended to provide reliable, emissions-free baseload power at large scale.
CleantechClimate TechEnergyLos Angeles, US
Brad Hartwig(Founder)in
Co-investorsCantos VenturesChrysalixCongruent VenturesGigascale CapitalVoyager PartnersChaac Ventures+3 more
Arbor is an AI platform that turns an organization's video footage — webinars, interviews, and events — into a suite of repurposed content including clips, social posts, blog articles, email sequences, and pull quotes, with automatic brand templates and voice controls.
AI & Machine LearningMarketing TechSaaS
Co-investorsFoundersEdgeChaac VenturesComma CapitalLOWERCARBONNext Play Ventures
Arbor provides a platform for measuring carbon emissions across supply chains using supply-chain-specific data points rather than global averages, enabling calculations in minutes instead of months or years.
CleantechClimate TechData & InfrastructureEnterprise SoftwareImpact & Social GoodSaaS
Danny Grande(Founder)in
Co-investorsStartup TNTThin Air LabsChaac VenturesComma CapitalGigascale CapitalLowercarbon Capital+1 more
Aryeo is a platform for real estate media professionals and photographers to manage booking, client management, scheduling, and delivery of listing media such as photos, 3D home tours, floor plans, and AI virtual staging.
Marketing TechPropTechSaaSBoston, US
Branick Weix(Executive Officer, Director)in
Co-investorsAmplo VenturesHyperplane Venture Capital
Attention provides AI-powered sales tools for revenue teams, automating CRM data entry and providing real-time sales coaching to improve call outcomes and rep productivity.
AI & Machine LearningEnterprise SoftwareSaaSSales Tech
Anis Bennaceur(Founder)inMatthias Wickenburg(Founder)in
Co-investorsAglae VenturesAlvenEniac VenturesRTP GlobalFrstLiquid Ventures
Beauty Bakerie is a cosmetics brand that sells makeup remover wipes and other beauty products.
ConsumerDirect to ConsumerE-commerceWellness & Fitness
Cashmere Nicole(Founder and Leader)
Co-investorsMontage CapitalUnilever VenturesNew Voices
Betterview provides a property intelligence platform that combines high-resolution aerial imagery with AI to detect roof condition, property perils, and risk factors, and integrates 2,500+ external data points with insurers' internal policy data.
AI & Machine LearningInsurTechMobility & TransportationPropTechSan Francisco, US
Dave TobiasDavid Lymanin
PartnerAaron Holiday· led
Co-investors500 GlobalManchesterStory Group, LLC
Bigeye is a data observability platform that monitors and improves the reliability of datasets and pipelines for data engineering teams.
AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareDaly City, US
Kyle Kirwan(Co-founder)inEgor Gryaznov(Co-founder)in
Co-investorsCoatue ManagementRackhouse Venture Management LpSequoia CapitalCostanoa VenturesIn-Q-Tel
Causal provides an extended planning and analysis (xP&A) platform for finance teams, offering budgeting, forecasting, scenario planning, and reporting that connects data across departments.
Enterprise SoftwareFintechSaaSClaymont, US
Taimur Abdaal(Executive Officer, Director, Promoter)inLukas Koebis(Executive Officer, Director, Promoter)
Co-investorsAccelCoatue ManagementAmity VenturesFlex Capital PartnersGlasswing VenturesTAU Ventures
Causely builds autonomous reliability software that helps engineering teams prevent incidents and reduce troubleshooting time in cloud-native environments.
AI & Machine LearningCloud ComputingDeveloper ToolsEnterprise Software
Dr. Shmuel Kliger(Founder)
Co-investors2.12 AngelsGlasswing VenturesTau VenturesAmity VenturesTAU Ventures
Spring, US
Alexander Whatley(CEO)
BoardJohn Cowgill(Director)in
Co-investorsTorch CapitalCostanoa VenturesVertex Ventures
Data Center Frontier is a media and publishing organization covering the data center industry, cloud computing infrastructure, and artificial intelligence-era digital infrastructure.
Cloud ComputingData & InfrastructureMedia & EntertainmentCentral New Jersey, US
Rich Miller(Founder)in
Co-investorsAngeles Equity
DeepSource provides developer tools for code quality and security.
AI & Machine LearningCybersecurityDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US
Sanket Saurav(Co-founder & CEO)inJai Pradeesh(Co-founder, President)in
Co-investorsFundersClubEssence Venture CapitalHack VCY CombinatorLiquid Ventures
Edera builds products focused on secure computing.
Cloud ComputingCybersecurityDeveloper Tools
Alex Zenla(Founder)in
Co-investorsEniac VenturesFPVGenerationshipM12 (Microsoft's Venture Fund)Mantis CapitalRosecliff Ventures+2 more
Edge AI is an analytics platform that lets users query complex commodity data in natural language, model scenarios, and stress test market conditions to surface trade insights.
AI & Machine LearningFintechSaaSNew York City, US
Shihab Malik(Founder)in
Co-investorsConvective Capital
Ellis is a platform for private credit fund managers that ingests, structures, validates, and reconciles data from disparate sources such as loan tapes, general ledgers, and fund admin reports.
AI & Machine LearningFintechSaaS
Co-investorsWilshire Lane CapitalFirst Round CapitalKhosla VenturesSlow Ventures
Ellis is a modern immigration law firm that combines legal services with a software platform to manage U.S. immigration and visa processes for companies.
HR TechLegalTechSaaSNew York City, US
Co-investorsAdapt VenturesV1 VCKhosla VenturesSlow Ventures
EngineEars is a platform that connects musicians with recording studios and engineers for booking and collaboration, while also providing music distribution and direct-to-fan sales tools.
B2B MarketplacesCreator EconomySaaSLos Angeles, US
Luke Sorenson(Founder)in
Co-investorsDrive CapitalSlauson & Co.
Forterra develops autonomous weapons, sensors, and battlefield systems using distributed control networks for defense operations.
AI & Machine LearningDefense TechRobotics
Alberto Lacaze(Chairman of the Board and President)inJoseph Putney(Chief Technology Officer)in
Co-investorsCRESCENT COVE CAPITALEnlightenment CapitalGlynn Capital ManagementNightDragonSalesforce VenturesSoftBank Vision Fund+8 more
Genially is a platform for creating interactive and animated content, with built-in AI tools for content generation.
Creator EconomyEdTechSaaS
Luis García Díez(Founder)in
Co-investorsBrighteye VenturesOwl Ventures
Genially is a content creation platform for building interactive presentations, courses, quizzes and games, with built-in AI agents, templates, and LMS integration via SCORM and LTI.
AI & Machine LearningEdTechSaaS
Luis García Díez(Founder)in
Co-investorsAthos CapitalCiveta InvestmentMarket One CapitalGP BullhoundJME VenturesOwl Ventures
Goldbelly is an online marketplace that ships iconic foods, meals, desserts, regional specialties, and gourmet food gifts from restaurants and local shops to customers across the United States.
ConsumerE-commerceFoodTechMarketplacesMobility & TransportationNew York City, US
Joe Ariel(Founder/CEO)inJoel Gillman(Founder/Vice President of Engineering)inVanessa Torrivilla(Founder/CPO)inTrevor Stowin
PartnerAaron Holiday· led
Co-investors500 GlobalCrunchFundSpectrum EquityTuesday CapitalY CombinatorACE & Company+1 more
New York City, US
Co-investorsClimate Tech PartnersTechstarsGreat Oaks Venture CapitalLiberty City VenturesRothenberg VenturesSparkLabs Global Ventures+1 more
InPharmD is a medical literature research platform that analyzes published studies to answer clinical pharmacology questions, specifically focused on adverse drug reactions and medication safety.
AI & Machine LearningDigital HealthHealthtechAtlanta, US
Ashish Advani(Founder)inTulasee Rao Chintha(Founder)in
Co-investorsAsymmetry VenturesAtlanta Tech VillageY Combinator
Iterable provides customer communication and engagement software that enables brands to create targeted messaging experiences across email, SMS, push, and other channels.
AI & Machine LearningEnterprise SoftwareMarketing TechMedia & EntertainmentSaaSSan Francisco, US
Andrew Boni(Co-founder, CEO (2021-2025))inJustin ZhuinHaoran Zhu(Executive Officer, Director)
BoardSabri Murat Bicer(Director)
PartnerAaron Holiday· led
Co-investors500 GlobalAngelPadArtisanal VenturesBrighter CapitalCRV (Charles River Ventures)Delta-v Capital+7 more
Lunchbox Entertainment develops competitive gaming experiences.
Gaming
Arik Torkelson(Founder / Chief Game Officer)inJack Wink(Founder / Co-CEO)Max Wink(Founder / Co-CEO)in
Co-investorsRyze LabsCoatue ManagementPrimaryPrimary Ventures
Lyte operates a network of kiosks where users rent and return portable smartphone chargers via credit card or through the Lyte app, with options like day-passes and subscriptions.
ConsumerHardwareIoTSan Mateo, US
Dajiang Wei(Founder)in
Co-investorsBling CapitalExpansion Venture CapitalValkyrie
Meridian Clean Energy focuses on long-term energy system decarbonization through the acquisition and management of renewable energy assets.
CleantechClimate TechEnergyOakland, US
John(Co-founder & CEO)Peter(Co-founder & Managing Partner)
Co-investorsPrelude VenturesAndreessen Horowitz
MM.LaFleur is a personal styling service that delivers curated professional clothing selections to subscribers.
ConsumerDirect to ConsumerE-commerceNew York, US
Co-investorsElizabeth Street VenturesGrace Beauty Capital
Momos is an AI-powered customer platform used by multi-location restaurant, retail and F&B brands to manage the customer lifecycle.
Sai Alluri(Founder)in
Co-investorsCaptii VenturesK3 VenturesAlpha Wave GlobalCorrelation VenturesFJ LabsPeak XV Partners+3 more
Momos provides AI agents for hospitality brands that automate guest relations across channels such as reviews, SMS, email, and third-party delivery, auto-resolving support tickets and generating customer experience insights.
AI & Machine LearningMarketing TechSaaS
Sai Alluri(Founder)in
Co-investorsAlpha Wave GlobalBrainstorm VenturesHOF CapitalCaptii VenturesCorrelation VenturesFJ Labs+5 more
Nanit makes a smart baby monitor system with 1080p HD video, computer-vision sleep tracking, breathing monitoring via sensor-free garments, and environmental tracking, plus a companion app with subscription-based sleep and development analytics.
Digital HealthHardwareIoT
Anushka Salinasin
PartnerAaron Holiday· led
Co-investorsEastward Capital PartnersGV (Google Ventures)HCVCRRE VenturesSpringcoast Capital PartnersStory Ventures+2 more
Navattic builds interactive product demo software that helps sales teams engage buyers and accelerate deal closure.
Enterprise SoftwareMarketing TechSaaSSales TechNew York City, US
Neil McLean(Founder)inRandy Frank(Founder)inChris Hoyle(Founder)in
Co-investorsCanvas VenturesLighthouse Network Ventures LlcRecall CapitalY Combinator
o11 builds AI agents integrated into enterprise applications.
AI & Machine LearningEnterprise SoftwareFintechSaaSSan Francisco, US
Aryah Oztanir(Founder / CEO)inAjay Misra(Founder)in
Co-investorsY Combinator
Oort provided identity security and threat detection, now part of Cisco as Cisco Identity Intelligence, offering visibility into an organization's identity population and helping move toward passwordless authentication.
CybersecurityEnterprise SoftwareSaaSHarvard, US
Matthew Caulfield(Executive Officer, Director)
Co-investors.406 VenturesCisco InvestmentsDreamit VenturesEnergy Impact PartnersArgon VenturesEnergy Revolution Ventures+2 more
Overtime builds and operates sports leagues and branded content properties for younger audiences globally, generating revenue through sponsorships, licensing, media rights, and e-commerce.
Creator EconomyMedia & EntertainmentSports Tech
Dan Porter(Founder & CEO)Zack Weiner(Founder)in
Co-investors359 CapitalAndreessen HorowitzBezos ExpeditionsBlack CapitalSpark CapitalWinslow Capital+11 more
Overtime creates and operates new sports leagues and media IP — including OTE and OT Select in basketball and OT7 and OT Nationals in football — while producing over 150 weekly pieces of original sports content for its global audience of next-generation fans and athletes.
ConsumerMedia & EntertainmentSports TechBrooklyn, US
Daniel Porter(Executive Officer, Director)Zachary Weiner(Founder)inZack Weiner(Founder)in
Co-investors359 CapitalAndreessen HorowitzBezos ExpeditionsBlack CapitalSpark CapitalWinslow Capital+15 more
Streaming for next-gen video creators in AI, XR, and blockchain
New York City, US
Co-investorsColopl NextDG Daiwa VenturesGFR FundSocial StartsSony Ventures CorporationTechstars
Redblock builds agentic AI that automatically executes identity and access management actions—such as joiner/mover/leaver lifecycle changes, account aggregation, and access revocation—inside business applications that don't integrate with existing IAM systems.
AI & Machine LearningCybersecurityEnterprise Software
Repacket builds security software that detects and prevents employee mistakes in real time.
AI & Machine LearningCybersecurityEnterprise SoftwareSaaSVancouver, CA
Noah Stanford(Founder)in
Co-investorsY CombinatorInitialized Capital468 Capital
Resident is a direct-to-consumer mattress company that manufactures and sells memory foam and hybrid mattresses under brands including Nectar, DreamCloud, Awara, and Siena.
ConsumerDirect to ConsumerE-commerceLas Vegas, US
Eric Hutchinson(Co-Founder & CEO)inRan ReskeinCraig SchmeizerinSharon DaganinTomer HatavinScott McLeod(Co-Founder & Chief of Staff)in
Co-investorsConductive VenturesGlynn Capital ManagementLiquidity CapitalNexus Capital ManagementTop Corner CapitalVCFA Group
Boston, US
Michael Gresty(Executive Officer, Director)Irina Mladenova(Executive Officer, Director)
BoardDominic Endicott(Director)inNnamdi Okike(Director)inJeff Herrmann(Director)
Co-investorsWalnut Venture Associates
Risotto is an AI help desk platform for internal support across multiple departments (IT, HR, Finance, Legal, Security) that automates repetitive questions, routes tickets, and manages access control by integrating with knowledge bases and communication tools like Slack and Teams.
AI & Machine LearningEnterprise SoftwareHR TechSaaSSan Francisco, US
Aron Solberg(Founder)inAlex Confer(Founder)inChris Paul(Founder)in
Co-investorsBonfire VenturesRitual CapitalTranspose Platform ManagementY CombinatorOrange Collective
Sequence develops 3D-printed mesh-silicone orthotic insoles combined with objective movement analysis of the kinetic chain (feet through spine), using standing foot scans and dynamic gait data to provide targeted sensory support that helps improve everyday movement.
HardwareHealthtechMedical DevicesBredebro, DK
Co-investorsKRINGAlabama FuturesAleph
Sequence builds a financial operating system that uses seven AI agents to automate accounting workflows, providing real-time financial visibility and handling multiple languages and tax regimes.
AI & Machine LearningFintechSaaS
Co-investorsTetradAlabama FuturesAleph
Setpoint develops wireless climate control networks for multi-room buildings, allowing users to monitor and automate indoor climate conditions in individual rooms through its Climate Intelligence Platform.
AI & Machine LearningClimate TechEnergyEnterprise SoftwareIoTPropTechSaaS
Co-investorsFusion VCGateway Capital PartnersAndreessen HorowitzWells Fargo Advisors
Setpoint provides a technology platform for loan origination and syndication, helping lenders and originators manage loan relationships and capital transactions with improved standardization and reduced operational error.
Enterprise SoftwareFintechSaaS
Stuart Wall(CEO, Co-founder)inBen Rubenstein(President, Co-founder)inMichael Lam(CIO, Co-founder)in
Co-investorsAndreessen HorowitzATX Venture PartnersFloating PointNextView VenturesVesta Ventures75 & Sunny
Shield AI develops AI pilot systems for military applications including aircraft, drones, ships, satellites, and submarines.
AI & Machine LearningDefense TechSan Diego, US
Brandon Tseng(President & Co-Founder)inRyan Tseng(President, Co-Founder & Chief Strategy Officer)inAndrew Reiter(Co-Founder)inKingsley Afemikhe(Executive Officer)inGary Steele(Chief Executive Officer)in
BoardKeith Dunleavy(Director)
Co-investorsAdvaita CapitalAlpha PartnersAltra VentureAndreessen HorowitzBeyond CapitalBooz Allen Ventures+34 more
Shop Circle is a holding company that acquires and modernizes B2B enterprise software businesses, applying AI to operate and grow the companies it owns.
AI & Machine LearningEnterprise SoftwareSaaSLondon, GB
Gian Maria Gramondi(Founder)in
Co-investors3VCBlackSheep VenturesCDP Venture CapitalEUREKA! VenturePrimo VenturesQED Investors+3 more
Solidus Labs provides compliance and market monitoring software for cryptocurrency and traditional finance.
Crypto & Web3CybersecurityEnterprise SoftwareFintechNew York, US
Asaf Meir(Executive Officer, Director)inChen Arad(Director)inPraveen Kumar(Executive Officer, Director)Praveen K. Dosodia(Founder)
BoardProsor Lior(Director)Shimon Mazor(Director)
Co-investorsBeacon VCDeclaration PartnersEvolution Equity PartnersF-Prime CapitalHanaco Venture CapitalEvolution Technology+3 more
Spiketrap is a provider of conversation intelligence, applying AI to analyze online conversations.
AI & Machine LearningData & InfrastructureMarketing TechSan Francisco, US
Virgilio Pigliucci(Executive Officer, Director, Promoter)Kieran Fitzpatrick(Executive Officer, Director, Promoter)
PartnerAaron Holiday· led
Co-investorsLighter CapitalPathbreaker VenturesOceans VenturesSusa Ventures
Squire operates a two-sided platform where customers can book appointments with barbers while shop owners gain access to integrated booking, payment processing, inventory, and payroll tools to manage their operations.
ConsumerNew York City, US
Songe LaRon(Founder/CEO)inDave Salvant(Founder/President)in
PartnerAaron Holiday· led
Co-investorsAltaIR CapitalAurumCRV (Charles River Ventures)Debut CapitalICONIQMaccabee Ventures+6 more
Strella provides a research and market intelligence platform aimed at consulting and investment teams, helping them gather insights faster than traditional research methods.
AI & Machine LearningData & InfrastructureMarketing TechSaaSNew York City, US
Priya Krishnan(Founder)inLydia Hylton(Founder)in
Co-investorsBessemer Venture PartnersDecibel PartnersMVP Ventures
Thinknum provides data intelligence platforms that track and analyze alternative data sources, including LinkedIn company profiles, to measure business metrics like employee headcount trends and follower growth over time.
Data & InfrastructureEnterprise SoftwareFintechSaaS
Gregory UgwiinJustin Zhen
Co-investors500 GlobalPejman Mar Ventures
True Anomaly designs and builds hardware and software systems for space security and defense.
Defense TechHardwareSpace TechCentennial, US
Even Rogers(CEO and Co-Founder)inKyle Zakrzewski(Chief Engineer and Co-Founder)inThomas Nichols(Executive Officer, Director)Daniel Brunski(Director)in
BoardJesse Michaels(Director)Austin Bishop(Director)
Co-investorsAccelACME CapitalBlack FlagChampion Hill VenturesCortado VenturesEclipse Ventures+14 more
Variance provides AI agents that conduct financial crime investigations for regulated institutions, automating evidence collection and analysis across compliance levels while maintaining audit trails and explainability.
AI & Machine LearningCybersecurityEnterprise SoftwareFintechSan Francisco, US
Karine Mellata(Founder)inMichael Lin(Founder)inJames Gross(Executive Officer, Director)Noah Brier(Executive Officer, Director)
BoardSteve Schlafman(Director)
Co-investorsTen ElevenUrban InnovationY CombinatorOkta VenturesRRE Leaders
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Negotiatus Corp.ReflexAI, Inc.Setpoint Technologies Inc.VividlyAbacusAccendAcclaimAgencyAirfoldAliceAptyAthena IntelligenceBeFreedBeSpokeBesxar SpaceCondorCotissCrescendo HealthCube DevDiagonalECLFirestormFly LabsGeneral AnalysisGimlet LabsHallwayHanover ParkHaplotype LabsHockeyStackInner BalanceInnerwellJackpotJudyKickoffLaunchableLeagueAppsLegendLinotypeMerge VRMerokaOnDatOrderPairAIPanther LabsPointhoundPomoPoshlyReflex AIRosieRunAnywhereSandtableShift5SkyDropSlopeSourceSource 3SpongeStradaSuperteacherTraverseUpsideUSCTVoice AI
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 11
1 IPOs · 10 acquisitions · showing 10Fiscal NoteOTC: NOTEAbacusacq. by CertifyAliceacq. by ExpediaAryeoacq. by Zillow GroupFly Labsacq. by GoogleLaunchableacq. by CloudBeesOnDatacq. by Akamai TechnologiesPanther Labsacq. by DatabricksPoshlyacq. by SuzyRosieacq. by Instacart
Portfolio news
latest coverage across their companies
Overtime · finance.yahoo.com · Aug 22, 2026

Meridian · finance.yahoo.com · Aug 20, 2026
Overtime · theinsurancemaze.com · Aug 19, 2026
Edge · nytimes.com · Aug 19, 2026
Arbor · mlive.com · Aug 18, 2026
Clerq · siliconangle.com · Aug 18, 2026

Attention · peakprosperity.com · Aug 16, 2026
Frequently asked questions
- How many investments has 645 Ventures made?
- 645 Ventures has 154 tracked investments, 11 of which have exited, including 17 dated in the last 24 months.
- What stage does 645 Ventures invest at?
- 645 Ventures invests at the Pre-Seed, Seed, Series A, Series B stages.
- What is 645 Ventures's typical check size?
- 645 Ventures typically writes checks of $1M – $5M.
- What sectors does 645 Ventures focus on?
- 645 Ventures focuses on AI & Machine Learning, Consumer, Data & Infrastructure, Enterprise Software, Fintech, SaaS, Sector Agnostic, Space Tech.
- Where is 645 Ventures located?
- 645 Ventures is headquartered in New York, US.
- Does 645 Ventures lead rounds?
- Yes, 645 Ventures leads investment rounds.
- Who does 645 Ventures co-invest with?
- 645 Ventures most often shares deals with Y Combinator, 500 Global, FJ Labs, among 198 tracked co-investors.
Media · Podcasts & interviews
featuring the team448th 1Mby1M Entrepreneurship Podcast With Nnamdi Okike, 645 Ventures
1Mby1M Roundtables · Nnamdi Okike
Nnamdi Okike on Building 645 Ventures, Bias in Fundraising, and Being a Boston Sports Fan in New ...
Something Ventured Podcast · Nnamdi Okike
Watch CNBC's full interview with 645 Ventures' Nnamdi Okike
Nnamdi Okike · cnbc.com
645 Ventures' Nnamdi Okike on investing in tech's 'behavioral change economy'
CNBC Television · Nnamdi Okike
448th 1Mby1M Roundtable June 27, 2019: With Nnamdi Okike, 645 Ventures
1Mby1M Roundtables · Nnamdi Okike
Fireside Chat: 645 Ventures Co-Founder Aaron Holiday
Aaron Holiday · vimeo.com
Co-investors · 68
Andreessen Horowitz (a16z) is a venture capital firm founded in 2009 by Marc Andreessen and Ben Horowitz, known for pioneering the platform model with a large team of operators supporting founders across stages.
FJ Labs is an early-stage investment firm specializing in marketplaces and network-effect businesses, taking an angel-style co-investment approach alongside institutional venture funds worldwide.
Costanoa Ventures is an early-stage venture capital firm that backs a select group of founders solving large, difficult problems, positioning itself as a long-term, operationally engaged partner from a company's earliest days through later milestones.
Chaac Ventures is an early-stage venture firm that backs founders connected to the Princeton University tech and innovation ecosystem, leveraging that global network to help portfolio companies grow.
CRV is a venture capital firm that backs founders at the seed and Series A stages, focusing on those with deep conviction and unique insights.
Great Oaks Venture Capital is a New York-based early-stage investor that partners with founders at the earliest stages of company building across the United States.
Eniac Ventures partners with early-stage founders, backing companies from 0 to 1.
Liquid 2 is an early- and growth-stage venture capital firm that invests in founders across all sectors of technology, providing capital along with support from a network of operators.
QED Investors is a venture capital firm focused on financial services, founded by former Capital One executives to back founders bringing transparency and fairness to fintech.
Rally Ventures is an investment firm focused on business technology companies, backing a select group of high-potential startups to help them grow market impact and value.
Amity Ventures is an early-stage venture firm that leads rounds, works closely with founders, and maintains a deliberately concentrated portfolio of only 3-5 investments per year.
Craft Ventures is a venture capital firm run by a team of former founders, operators, and investors who partner closely with founders to help build and scale technology companies.
▶56 more co-investors
Greylock PartnersInsight PartnersEverywhere VenturesSpark CapitalTiger Global ManagementSusa VenturesSierra VenturesTrinity VenturesFoundryPrimary Venture PartnersHigh AlphaDecibel PartnersOwl VenturesSilverton PartnersFlare Capital PartnersEvolution Equity PartnersMarket One Capital3VCGrace Beauty CapitalCantos VenturesPrimo VenturesCurql Collective, LLCRedpoint VenturesBain Capital VenturesSapphire VenturesOffline VenturesUpHonest CapitalFreestyle CapitalStride VCDN CapitalBase10 PartnersAccompliceGaingelsLeft Lane CapitalAlleyCorpTeamworthy VenturesFlourish VenturesAnorak VenturesBaruch Future VenturesSummit PartnersExpansive VenturesEndeavor CatalystGutter CapitalThirty Five Ventures (35V)Vera EquityContour Venture PartnersSoftBank CapitalANIMO VenturesPage One VenturesLiveOak VenturesProof GroupBain Capital CryptoA*Infinite CapitalMetaplanetLearnLaunch Fund Accelerator
Firms observed investing alongside 645 Ventures, from public investor directories. Shared companies are the overlap with 645 Ventures's recorded portfolio.
Similar investors
Khosla Ventures is a venture capital firm founded by Vinod Khosla.
OMERS Ventures is a venture capital firm that invests in founders globally, with investment teams based in New York, Palo Alto, and Toronto.
Callapina Capital is an operator-led, conviction-led venture firm focused on backing Indian-origin founders building category-defining companies across the US-India corridor. It has invested for over a decade with a Fund I portfolio and is now raising Fund II.
Alumni Ventures (AV) is a venture capital firm that co-invests alongside lead VCs in startups, backing founders with capital and access to a large investor and operator community.
Primo Ventures is a venture capital firm that invests in early-stage companies. The firm is led by founders with prior entrepreneurial experience.
























































































































































































































