National Science Foundation
Grant agencyAlexandria
Investment thesis
NSF is a U.S. federal agency that funds science and engineering in all fields except the medical sciences. It supports basic, curiosity-driven research as well as solutions-oriented, use-inspired research with potential societal benefit. Its investments account for roughly a quarter of federal support to U.S. colleges and universities for basic research. NSF makes roughly 11,000 competitive awards annually across research, education and training, backing ~1,900 institutions and ~350,000 researchers, entrepreneurs, students and teachers. It also funds partnerships among academia, industry, nonprofits and government, and invests in major research infrastructure and education programs spanning pre-K through graduate school. Awards are decided via rigorous merit review.
Source: firm website, verified Aug 3, 2026.
SBIR/STTR awards · non-dilutive funding
Federal grants and contracts to small businesses — no equity taken. Awards on record 1983–2023.
11,238 Phase I · 3,558 Phase II · 1,538 via STTR · most-funded states: CA, MA, NY, CO, TX
| Recent awardees | Phase | Year | Amount |
|---|---|---|---|
| MOLTEN SALT SOLUTIONS, LLCSanta Fe, NM | Phase II | 2023 | $1M |
| MAPLESS AI INCPittsburgh, PA | Phase II | 2023 | $1M |
| ALERJE, INCDetroit, MI | Phase II | 2023 | $1M |
| Optimeos Life Sciences, Inc.Princeton, NJ | Phase II | 2023 | $1M |
| Tempo Therapeutics IncSan DIego, CA | Phase IISTTR | 2023 | $1M |
| AIDAR HEALTH INCPikesville, MD | Phase IISTTR | 2023 | $1M |
| Aeromutable CorporationRamona, CA | Phase II | 2023 | $1M |
| MENTE, INC.Boston, MA | Phase II | 2023 | $1000K |
| InfusenseNashville, TN | Phase II | 2023 | $999.9K |
| EMTRUTH, INC.Glendale, CA | Phase II | 2023 | $999.7K |
| VECTECH, INC.Baltimore, MD | Phase II | 2023 | $999.5K |
| SUNFLY BRANDS, INC.Seattle, WA | Phase II | 2023 | $999.4K |
| AV-CONNECT, INC.Berkeley, CA | Phase II | 2023 | $999.3K |
| OFF-WORLD, INC.Pasadena, CA | Phase II | 2023 | $999.1K |
| Docugami, Inc.Kirkland, WA | Phase II | 2023 | $998.3K |
| XL BATTERIES INCBrooklyn, NY | Phase II | 2023 | $997K |
| NATRX INCRaleigh, NC | Phase II | 2023 | $995.3K |
| PSEUDOLITHIC INC.MCLEAN, VA | Phase II | 2023 | $995.1K |
| GRAIN WEEVIL CORPORATIONAurora, NE | Phase II | 2023 | $994.4K |
| IQINETICS TECHNOLOGIES INC.Philadelphia, CA | Phase II | 2023 | $989.9K |
| OPTICAL WATERS LLCAmherst, MA | Phase II | 2023 | $983.8K |
| RENEWCO2 INC.Cranford, NJ | Phase IISTTR | 2023 | $981.8K |
| Aquagga, Inc.Tacoma, WA | Phase II | 2023 | $979.3K |
| LifEngine Animal Health Laboratories IncorporatedRochester, MN | Phase II | 2023 | $973.9K |
| Radwave Technologies Inc.St Paul, MN | Phase II | 2023 | $973.8K |
| MUUKLABS INCRaleigh, NC | Phase II | 2023 | $971.8K |
| ECLIPSE REGENESIS, INC.Menlo Park, CA | Phase II | 2023 | $970.5K |
| NOBLE GAS SYSTEMS INC.Novi, MI | Phase II | 2023 | $969.2K |
| Ictero Medical, Inc.Houston, TX | Phase II | 2023 | $966.6K |
| THIOZEN INC.Belmont, MA | Phase II | 2023 | $954.5K |
Source: SBIR.gov award data (U.S. Small Business Administration). SBIR/STTR awards are non-dilutive — the agency takes no equity.
Founder mafia
The National Science Foundation mafia →14 people who came through National Science Foundation went on to found or lead other companies.
+ 2 more
What they invest in
from 1445 of 2316 portfolio companiesDeep Tech ×562Hardware ×491New Materials ×282Biotech ×281AI & Machine Learning ×265Healthtech ×237Cleantech ×211Medical Devices ×197
HQs:United States×712Puerto Rico×3Canada×1China×1United Kingdom×1Netherlands×1
Investments · showing 1200 of 2316
founders shown can be your intro pathBy year:2025 · 22023 · 1182022 · 1382021 · 2202020 · 2082019 · 2212018 · 1712017 · 992016 · 2922015 · 1512014 · 1172013 · 1082005 dated
Dallas, US
Thomas J. Schaefer(Executive Officer, Director)Matthew T Plavan(Executive Officer)Rajendra Ketkar(Executive Officer, Director)Uday Garg(Director)Eric Ray(Director)Darby Shupp(Director)
BiotechFarmington, US
Azim Munivar(Executive Officer, Director, Promoter)
BoardStella Robertson(Director)inTravis Whitfill(Executive Officer, Director, Promoter)in
Co-investorsBios PartnersKdT Ventures
Ginkgo Bioworks builds autonomous labs and offers cell-programming and bioengineering services for the biopharma, agriculture, and industrial biotech markets.
AgTechAI & Machine LearningBiotechDeep TechHealthtechBoston, US
Jason Kelly(Founder)inAustin Che(Founder)inTom Knight(Founder)inBarry Canton(Founder)inReshma Shetty(Founder)in
BoardReshma Sohoni
Co-investors11.2 CapitalB3 HoldingCannage CapitalCool Climate CollectiveDCVC (Data Collective)Designer Fund+16 more
Infleqtion develops quantum-enabled hardware and AI-powered products for positioning, navigation, and timing (PNT), including optical atomic clocks, quantum sensing, and quantum computing, serving commercial organizations and government/defense customers.
Deep TechDefense TechHardwareQuantum ComputingLouisville, US
Dana Anderson(Founder)Pranav Gokhale(Chief Technology Officer)inPaul Lipman(Chief Revenue Officer)inJason D. Hall(Chief Legal Officer)Ilan Hart(Chief Financial Officer)inMatthew J. Kinsella(Chief Executive Officer)
Co-investorsBreakthrough VictoriaCaruso VenturesForma PrimeGlynn Capital ManagementIn-Q-TelS Ventures+5 more
Oragenics is a biotech company developing ONP-002, an intranasal neurosteroid drug delivered via a proprietary nasal device to treat the underlying brain injury in concussion patients.
BiotechLongevityMedical DevicesTampa, US
Alan Joslyn(Executive Officer, Director)Michael Sullivan(Executive Officer)
BoardRobert Koski(Director)Frederick Telling(Director)Alan Dunton(Director)Charles Pope(Director)
Senti Bio develops cell and gene therapies for cancer and difficult-to-treat diseases using synthetic biology and engineered Gene Circuits to enhance precision, control, and selectivity in targeting tumor cells.
BiotechDeep TechMedical DevicesSouth San Francisco, US
Tim Lu(Co-Founder and Chief Executive Officer)inPhilip Lee(Executive Officer)Kanya Rajangam(President, Head of Research & Development and Chief Medical Officer)Yvonne Li(Executive Officer)James Collins(Director)
BoardDonald Tang(Director)
Co-investorsEvolution VC PartnersFlucas VenturesLifeforce CapitalLux CapitalMenlo VenturesNSG Ventures+3 more
Solid Power develops all-solid-state battery technology for automotive applications.
EnergyHardwareNew MaterialsLouisville, US
Douglas Campbell(Executive Officer, Director)Alexandra Gold(Executive Officer)Brandon Kelly(Executive Officer)Steve Furhman(Executive Officer)Joshua Buettner-Garrett(Executive Officer)David Jansen(Executive Officer, Director)
Co-investorsBMW i VenturesSnatched Ventures
Big Blue Technologies develops an electrified aluminothermic process for producing primary magnesium metal and calcium aluminate with lower energy use and emissions than the incumbent Pidgeon process.
Advanced ManufacturingCleantechNew Materials
Codon Learning offers a biology teaching and learning platform for colleges and universities, built on evidence-based course design principles such as backward design, high-structure course design, and cognitive science research on metacognition.
EdTechSaaSGolden, US
Ben Roberts(Co-Founder & CEO)inBenjamin W. Roberts(Executive Officer, Director)Greg Benson(Executive Officer)Vance Allen(Co-Founder and CTO)Leroy Hood(Co-Founder)Jennifer Knight(Co-Founder & Chief Academic Advisor)
DeepCharge operates a platform that predicts enterprise device failures using machine learning and IoT sensing technology.
AI & Machine LearningEnterprise SoftwareIoTLogistics & Supply ChainNeedham, US
Yousof Naderi(Founder)inMohammad Naderi(Executive Officer, Director)Kaushik Chowdhury(Executive Officer, Director)
Nextiles is a materials science company that combines patented fabric-based sensor and sewing technology with a data analytics platform to measure human performance, capturing forces, range of motion, and 3D motion from compression clothing.
HardwareNew MaterialsSports TechBrooklyn, US
George Sun(Chief Executive Officer)John Peters(Director)Matthew Evans(Executive Officer)
BoardMeredith McPherron(Director)in
Co-investorsDrive by DraftKingsPhoenix Capital Ventures
iT1 Nucleos provides AchieveDXP, a digital experience platform for secure, high-accountability learning, alongside hardware, services, and managed deployments serving government agencies, schools, colleges, and workforce partners.
EdTechEnterprise SoftwareGovTechSaaSTempe, US
Bryan Clifton(Co-founder, iT1)Guy Steinbrink(Co-founder, iT1)
Co-investorsScaleGood Fund LP (powered by TELUS)
Sensible Weather offers a Weather Guarantee product that automatically reimburses travelers up to 100% of their daily rate or booking cost when qualifying weather (such as rain or excessive heat) occurs during trips or outdoor activities like camping, golf, ski trips, theme parks, and concerts.
Climate TechInsurTechTravel & HospitalitySanta Monica, US
Nicholas Cavanaugh(Executive Officer, Director, Promoter)Nick Cavanaugh(Founder)Heidi A. Lawson(Director)
BoardJay Ganatra(Director)in
Co-investorsAmex VenturesInfinity VenturesWonder Ventures75 & SunnyInfinity VCWalkabout Ventures Llc
Shoelace Wireless develops mobile networking technology that combines multiple connections (Wi-Fi, cellular, Bluetooth) across single or nearby devices to speed up internet and video streaming on Android.
Deep TechIoTMobility & TransportationIrvine, US
Two EECS professors and two graduate students from UC Irvine and EPFL
3DEO is a metal 3D printing company that produces high-volume small metal parts and components using its patented Intelligent Layering process, paired with a Design for Additive Manufacturing service.
Advanced ManufacturingDeep TechHardwareTorrance, US
Payman Torabi(Executive Officer)Matthew Sand(President)Matthew Petros(Chief Executive Officer)Scott(CEO)
BoardNate Redmond(Director)inKen Hood(Director)in
Co-investorsAlpha EdisonFusionX VenturesHemisphere Ventures LLC
Co-investorsBoston Harbor Angels
4D Avionic Systems develops MissionClear, a UAV coordination engine that automatically detects and resolves conflicts in multi-drone missions before takeoff, working alongside the QGroundControl-4D ground control software.
Defense TechRobotics
A-Alpha Bio uses synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions for pharmaceutical discovery and development.
AI & Machine LearningBiotechDeep TechSeattle, US
David Younger, PhD(Chief Executive Officer & Co-Founder)Randolph Lopez, PhD(Chief Technology Officer & Co-Founder)David Younger(Executive Officer, Director, Promoter)inRandolph Lopez(Founder)in
Co-investorsAngel Collective Opportunity FundBreakout VenturesFarvatn VentureLux CapitalMadrona Venture GroupBoom Capital Ventures+1 more
Abalone Bio develops target-activating antibodies for difficult-to-drug disease targets by combining engineered biology with machine learning.
AI & Machine LearningBiotechDeep TechHealthtechSan Francisco, US
Richard Yu(Founder)inGustavo Pesce(Founder)in
Co-investorsHorizons VenturesMetaplanetY CombinatorBoxOne Ventures
ACatechol develops patented biomimetic surface engineering technologies, including long-lasting germicidal coatings, anti-biofouling and antimicrobial catheters, non-etching dental bonding/de-bonding, and biodegradable surgical adhesives.
BiotechMedical DevicesNew MaterialsSanta Barbara, US
Jin-Soo Ahn(Executive Officer, Director)Byung-Jun Ahn(Executive Officer, Director)
BoardEric Cook Ryan(Director)
AccuBreath develops AccuBreathEMS, a portable automated ventilation device that integrates RESCUE, BiPAP, and CPAP modes with pressure sensors and real-time airway monitoring to reduce acute lung injury in emergency care.
HardwareHealthtechMedical Devices
Spencer Madsen(CEO)
Aclarity makes the Octa System, an electrochemical oxidation technology that destroys PFAS "forever chemicals" on-site by breaking carbon-fluorine bonds.
CleantechClimate TechHardware
Co-investorsBURNT ISLAND VENTURESEcho River CapitalHG VenturesMaroon Venture Partners FundMassVentures
Acree provides custom thin-film PVD (Physical Vapor Deposition) and PECVD coating services, developing and depositing coatings such as biomedical, wear-resistant, corrosion-resistant, DLC, and transparent conductive oxide films.
Advanced ManufacturingDeep TechNew Materials
Acrigen develops precision gene editing systems based on CRISPR, using novel αCas and μCas nuclease libraries paired with engineered anti-CRISPR (ErAcr) proteins to reduce off-target edits.
BiotechDeep TechHealthtechKensington, US
Joseph Bondy-Denomy(Director)David Rabuka(Executive Officer, Director, Promoter)Karen Boezi(Director)
Co-investorsBerkeley CatalystDolby Family Ventures
Activated Research Company (ARC), founded in 2014, develops chemical analysis detection technologies such as gas chromatography add-ons (Polyarc and Jetanizer) that improve data accuracy and sample throughput.
Deep TechHardwareNew Materials
The company develops ALPro technology for electrical characterization of semiconductor layers at atomic-scale depth resolution, aimed at supporting process development, modeling, and manufacturing control.
Deep TechHardwareSemiconductors
Co-investorsSilicon Catalyst
HealthtechCarlsbad, US
Theodore DeFrank(Chief Executive Officer and President of Issuer)Patrick Yount(Chief Financial Officer of Issuer)Stephanie Liva(Director)August Sick(Director)Mary Janatpour(Director)Tammy Brach(Director)
Seattle, US
Jay Goyal(Executive Officer, Director)Deep Sran(Executive Officer, Director)
Co-investorsAtlanta Tech Village
Actuated Medical develops NeuralGlider, a precision brain access platform that uses electronically controlled ultrasonic motion to maintain trajectory during insertion through brain tissue and improve delivery of brain-directed therapies such as gene therapies to deep brain targets.
BiotechDeep TechHealthtechMedical DevicesBellefonte, US
Paul Frankhouser(Director)Robert Emert(Director)Maureen Mulvihill(Executive Officer, Director)
Adeptrix develops the exoBAMS platform, using antibody-based immunoaffinity capture of extracellular vesicles combined with MALDI mass spectrometry to profile proteins, lipids, metabolites and other molecules from a single blood sample.
AI & Machine LearningBiotechMedical Devices
Co-investorsFormation Venture Engineering
Adherent Technologies develops advanced materials technologies and production processes, including carbon fiber finishes, composite repair primers, nanomaterial surface treatments, powder towpregs, composite recycling methods, and specialty foams.
Deep TechDefense TechNew Materials
Advanced Ceramics Manufacturing produces water soluble mandrels, tooling, composite parts, and ceramic components for aerospace, defense, racing, research, and university applications.
Advanced ManufacturingDefense TechNew MaterialsTucson, US
Advanced Cooling Technologies (ACT) develops, engineers, and manufactures thermal management products and provides related services including product development, manufacturing, and post-delivery support such as spare parts, repairs, and field servicing.
Advanced ManufacturingDeep TechHardware
BiotechChicago, US
Erik B. Kulstad(President)Rick McCaulley(Director)
BoardMark Ritz(Director)Cliff Turner(Director)Don Morath(Director)Igal Ladabaum(Director)
ALT LLC engineers materials, structures, and on-device AI for robots, prosthetics, drones, and autonomous systems, combining synthetic tissues, high-strength composites, additive manufacturing, and edge machine learning.
AI & Machine LearningNew MaterialsRoboticsSanta Barbara, US
Ascience provides multi-body dynamics simulation services and physics-based modeling, including testing autonomy stacks for autonomous vehicles using 3D terramechanics to predict vehicle mobility on complex terrain.
Deep TechMobility & TransportationRobotics
ASC develops global shutter flash LIDAR (gsf-LIDAR), a solid-state, non-scanning time-of-flight 3D imaging and ranging camera that produces distortion-free point clouds for optical navigation, mapping, and situational awareness.
AI & Machine LearningDeep TechHardware
Advanced Silicon Group works in nanotechnology, using the tagline "Nanotechnology for Life."
BiotechDeep TechMedical DevicesNew MaterialsSemiconductorsLowell, US
Marcie Black(CEO & Co-founder)inBill Rever(Chief Marketing and Sales Officer & Co-founder)William Rever(Executive Officer, Director)
BoardAlan Watson(Director)Sarah Kelly(Director)
Co-investorsTenon Ventures
ATR Corp provides engineering services and specialized products including ship signatures technology, modeling and simulation, technical publications, and prototypes and production, largely supporting U.S.
Defense TechHardwareRoboticsBeltsville, US
Advanced Energy Materials (ADEM) develops nanomaterials and catalysts, including nanowire-based materials, hydrodesulfurization (HDS) catalysts, metal oxide alloys, and CO2 sorbents, along with manufacturing processes for bulk-scale production.
CleantechClimate TechEnergyNew Materials
Co-investorsKeyhorse Capital
Adventium Labs offers the CAMET Library, a subscription-based collection of model-based engineering and analysis tools that help system engineers and architects detect flaws in complex cyber-physical systems during the requirements and design phases.
Deep TechDefense TechDeveloper Tools
Advisory Aero builds FactoryTwin, an AI-powered manufacturing analytics platform that connects ERP, MES, and spreadsheet data to give factories visibility into on-time delivery, capacity, WIP, and root cause.
Advanced ManufacturingAI & Machine LearningSaaS
Aepnus is developing a sulfate recycling process that regenerates chemicals on-site from sodium sulfate waste, with a planned demonstration-scale plant designed to process over 500 tonnes of sodium sulfate annually.
Circular EconomyCleantechNew Materials
Co-investorsClean Energy VenturesISVLOWERCARBONLowercarbon CapitalVoyager PartnersIMPACT SCIENCE VENTURES+1 more
Aerogel Technologies develops and manufactures monolithic aerogels and Airloy Ultramaterials—mechanically robust, ultralight, superinsulating structural materials in form factors such as panels, 3D shapes, and thin films.
Advanced ManufacturingDeep TechNew Materials
Aeromutable develops active flow control technology that dynamically alters the aerodynamic behavior of heavy vehicles to reduce drag, cut fuel consumption, and improve maneuverability and safety.
CleantechHardwareMobility & Transportation
Co-investorsDorm RoomHAXTrue Wealth Ventures
Aerosens builds IoT platforms for the aviation industry using Bluetooth Low Energy (BLE) sensors paired with smartphones or tablets.
HardwareIoTSaaS
Co-investorsFlorida Funders
AeroShield is a materials science company that developed an ultra-clear silica aerogel, originating from research at MIT, aimed at improving the energy efficiency of buildings.
Advanced ManufacturingCleantechEnergyNew MaterialsCambridge, US
Elise Strobach(CEO)inKyle Wilke(Director)inDr. Elise Strobach(CEO)
BoardSusan Stewart(Director)Brandon Tinianov(Director)inStephen Venuto(Director)
Co-investorsClean Energy VentureMassMutual VenturesMassVenturesSBXi
Aerosol Devices builds instruments that collect, count, and size-classify airborne particles from 5 nanometers to 10 microns, including gentle capture of viruses, bacteria, and microbes while preserving viability and DNA/RNA.
BiotechDeep TechHardware
Agita Labs develops hardware security and computer architecture technology focused on secure computation and side-channel resistance techniques.
CybersecurityDeep TechHardwareAnn Arbor, US
Valeria Bertacco(Co-founder)Todd Austin(Co-founder)Lip-Bu Tan(Director)Amy Wirth(Chief Financial Officer)
Co-investorsOUP (Osage University Partners)
Agnitron Technology designs and manufactures MOCVD equipment, control software, and in-situ monitoring tools for growing wide-bandgap and ultra-wide-bandgap semiconductor materials such as gallium oxide and AlGaO alloys.
Deep TechHardwareSemiconductorsChanhassen, US
AgraFilms develops a plant protection technology that uses Dictyostelid amoebae and their anti-biofilm compounds to hunt and neutralize crop-associated bacteria, including biofilm-protected pathogens like potato soft rot.
AgTechBiotechFoodTech
Jonathan Irwin(Chief Executive Officer)
Charlottesville, US
Ameer Hamza Shakeel(Executive Officer, Director, Promoter)Payam Pourtaheri(Executive Officer, Director, Promoter)David Reese Blackwell III(Executive Officer, Director, Promoter)Yelda ?nal(Director)
BoardCarl M. Casale(Director)Robert Fraley(Director)
Co-investorsCavallo VenturesOspraie Ag ScienceZebra Impact Ventures
Agtec Innovations develops smart-release fertilizers, including controlled-release micronutrients, phosphorus products, coatings for DAP/MAP, and caged-urea that reduce nutrient runoff and improve crop yields.
AgTechCleantechNew MaterialsLos Altos, US
Chandrika Varadachari(Executive Officer, Director)Murli Varadachari(Executive Officer, Director)
Aidar Health develops health monitoring technology that provides real-time health insights and predictive analytics for individuals and their caregivers.
AI & Machine LearningDigital HealthHealthtechMedical Devices
Co-investorsMaryland TEDCOTEDCO
AIMdyn develops K-GAT (Koopman-based Generative Adaptively-Trained Transformer), a generative AI foundational model that ingests time-stamped data for forecasting, anomaly detection, and optimal decision-making and control.
AI & Machine LearningDeep Tech
Igor Mezic(Co-founder)
Aira offers remote, on-demand visual and American Sign Language interpreting through video, connecting blind, low-vision, Deaf, and hard-of-hearing users to professional interpreters via its Aira Explorer and Aira ASL apps.
Digital HealthHealthtechImpact & Social Good
Co-investorsBose Ventures
AIRCO builds modular systems that produce fuel, using carbon-capture and synthesis technology.
CleantechClimate TechEnergy
Co-investorsNew Climate VenturesToyota Ventures
Co-investorsMaryland TEDCOTEDCO
Deep-tech power electronics startup building compact, high-density high-voltage power conversion units.
Redwood City, US
Luke Raymond(Executive Officer, Director)Johan Andreasson(Executive Officer, Director)
BoardRichard Gottscho(Director)
Co-investorsLam Capital
AirMettle develops software that accelerates big data analytics by performing operations such as selecting, grouping, and aggregating data directly in the data lake using parallel processing, instead of moving data to analytic memory or a data warehouse.
Cloud ComputingData & InfrastructureEnterprise Software
Akanocure is a drug development company using a proprietary chemistry platform to create novel small-molecule therapies, with a focus on orphan and unmet needs in oncology and blocking metastatic processes.
BiotechHealthtechWest Lafayette, US
Philip L. Fuchs(Executive Officer, Director)Mohammad N. Noshi(Executive Officer, Director)Sherine M. Abdelmawla(Executive Officer, Director)
Co-investorsElevate Ventures
BiotechFredrick, US
Charles Daitch(Executive Officer, Director)Jon Davis(Executive Officer)Darrell Chandler(Executive Officer)George Rudy(Executive Officer)Jennifer Reynolds(Executive Officer)
BoardTom McMahon(Director)
Akorn Technology develops 100% natural edible coatings for fresh produce that slow ripening, reduce moisture loss, and inhibit microorganisms to extend the shelf life of fruits and vegetables.
AgTechFoodTechNew MaterialsBerkeley, US
Antonios Zografos(Executive Officer, Director)
Co-investorsUM6P Ventures
Akoustis designs and manufactures high-performance RF filters using its XP3F technology for high-frequency, ultra-wideband applications servicing frequencies from 8 to 20 GHz and beyond.
Deep TechHardwareSemiconductorsCornelius, US
Jeffrey Shealy(President & CEO)Lora Shealy(Secretary)
Co-investorsGENIUS NY
Akttyva Therapeutics is a drug-discovery company using an AI-assisted computational platform called AIDE, which combines physics-based approaches, molecule libraries, and experimental validation to develop targeted therapeutics.
AI & Machine LearningBiotechDeep TechWatertown, US
ALA Scientific develops and sells laboratory instruments for neuroscience and electrophysiology research, including perfusion systems (OctaFlow) and the BrainDancer dynamic fMRI calibration phantom paired with its NoiseNet deep-learning algorithm for correcting scanner noise.
Deep TechHardwareHealthtech
Albeado offers an AI platform that unifies enterprise data (emails, documents, data rooms, legacy systems) with causal reasoning, RAG-based search, automated reporting, and predictive modeling to support the investment lifecycle from deal sourcing to exit.
AI & Machine LearningEnterprise SoftwareFintechSaratoga, US
Raj Mamodia(Director)Partha Datta Ray(Executive Officer, Director)
Co-investorsID VenturesInvest Michigan
AlchLight is a technology firm specializing in ultrafast laser material fabrication, using lasers to create micro- and nano-structures on metals and glass at industrial scale for applications such as black/colored metals and superhydrophobic surfaces.
Advanced ManufacturingDeep TechNew MaterialsRochester, US
Alelo builds generative and conversational AI avatars for immersive, "learn by doing" training in soft skills, language, and culture, with performance assessment and data analytics for learners.
AI & Machine LearningEdTechHR Tech
W. Lewis Johnson(Dr., Founder)
Alerje develops FAIT, a software platform that supports oral immunotherapy (OIT) for food allergies, using AI predictions, behavioral science, and clinical workflows to help families and clinics manage daily treatment.
AI & Machine LearningDigital HealthHealthtechSaaS
Javier Evelyn(Founder & CEO)
Co-investorsBackstage CapitalChloe CapitalID VenturesJumpstart NovaMichigan RiseSeae Ventures
Algenesis develops plant-based, biodegradable polyurethanes intended to replace petroleum-based materials across manufacturing applications.
Circular EconomyCleantechNew Materials
Co-investorsBand of AngelsSwan Venture Fund
Aliro provides a full-stack software platform for quantum networking, including simulation, orchestration, and operating system solutions that enable enterprises and government agencies to plan and deploy quantum networks for applications like QPU interconnection and quantum-secured communications.
CybersecurityDeep TechEnterprise SoftwareQuantum ComputingBoston, US
Michael Cubeddu(Founder)in
Co-investorsBantam GroupCrosslink CapitalFlybridge Capital PartnersGutbrain VenturesiGlobe PartnersSamsung Next+2 more
Berkeley, US
James Matthew Mason(Executive Officer, Director)Bear Kaufmann(Executive Officer)Alejandro Abalos(Executive Officer)
BoardTom Dinwoodie(Director)Dan Kammen(Director)
Highlands Ranch, US
Daniel Konopka(Manager)Jeff Granato(Chief Executive Officer)Jason Seedig(Manager)
Allium Engineering designs and manufactures a stainless steel cladding process for steel rebar that prevents corrosion, extending the lifespan of construction structures while lowering cost and carbon emissions.
CleantechConstruction TechNew Materials
Steven Jepeal(Cofounder)Samuel McAlpine(Cofounder)
Co-investorsAera VCBay Bridge Ventures ClimateCastor Ventures (an Alumni Ventures Fund)Creative Destruction Lab (CDL)Propeller VC
Allotrope Medical makes electrical stimulation devices that integrate with surgical instruments to help surgeons visualize and assess urinary and digestive system structures during procedures.
HardwareHealthtechMedical DevicesHouston, US
Albert Huang(Founder/CEO)in
BoardMira Sahney(Director)David Franklin(Director)Donald Gonzales(Director)
Co-investorsRockies Venture ClubTexas HALO FundY Combinator
Altay Therapeutics develops small molecule inhibitors targeting transcription factors to treat serious diseases including facioscapulohumeral muscular dystrophy and cancer.
BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US
Ali Ozes(Founder)inOsman Ozes(Founder)in
Co-investorsCreative Destruction Lab (CDL)Tachyon VenturesY Combinator
Alva Health develops wearable medical devices that continuously monitor for early signs of stroke and alert emergency responders in real time.
AI & Machine LearningDeep TechHealthtechIoTMedical DevicesWellness & FitnessDallas, US
Sandra Saldana(Executive Officer, Director)
Co-investorsTechstars
BiotechLaguna Hills, US
George Guikai Wu(Executive Officer, Director)Yonglei Shang(Executive Officer, Director)Weian Zhao(Director)
Salem, US
ANTHONY LOCHTEFELD(Executive Officer)Richard Faubert(Director)George McNamee(Director)Allen Barnett(Director)Anthony Lochtefeld(Executive Officer, Director)
BoardGEORGE MCNAMEE(Director)
Ambi Robotics builds AI-powered robotic systems for parcel handling, including robotic stacking (Ambistack), small parcel sorting to last-mile (Ambisort), and AmbiOS, an operating system for robots.
AI & Machine LearningLogistics & Supply ChainRobotics
Co-investorsAhren Innovation CapitalBerkeley SkyDeck Fund
American GNC Corporation develops guidance, navigation, control and communications (GNCC) technologies, along with sensor networks, AI/machine learning, robotics and computer vision, sold through its coremicro product series including MEMS inertial measurement units.
Deep TechDefense TechRoboticsSimi Valley, US
Amphix Bio develops peptide therapeutics based on a supramolecular chemistry platform that forms nanostructure scaffolds to activate regenerative signaling in cells and tissues.
BiotechDeep TechChicago, US
Samuel Stupp(Co-founder & Chief Scientific Officer)Nicholas Sather(Executive Officer, Director)Nick Sather(Co-founder & Chief Executive Officer)Dévora Grynspan(Co-founder, Board Observer & Secretary)
BoardKok-Wai Wong(Director)Stephen R Wilson(Director)
Anactisis develops solvent-free separation technology to recover critical minerals such as scandium, gallium, and germanium from industrial waste streams including titanium dioxide acid leachates, coal combustion residuals, bauxite residues, and mining tailings.
CleantechDeep TechNew Materials
Sunnyvale, US
Seung-Hwan Song(Executive Officer, Director)Sihwan Kim(Director)
BoardShahrzad Naraghi(Director)Samir Chokshi(Director)in
Co-investorsLotte VenturesWe VenturesStarbridge Venture Capital Llc
Analytic Measures builds AI-powered literacy tools under the Caimber brand, offering automated, self-administered assessments and adaptive, personalized learning across listening, speaking, reading, and writing.
AI & Machine LearningEdTech
CAMET (Curated Access to Model-based Engineering Tools) is a subscription library of model-based engineering and analysis plugins for system engineers and architects working on complex cyber-physical and embedded systems.
Deep TechDefense TechDeveloper Tools
ANELLO Photonics develops silicon photonics-based inertial navigation systems, specifically its SiPhOG platform, which delivers optical gyroscope performance in a chip-scale form factor for GPS-denied environments.
Deep TechDefense TechHardwareSemiconductorsSanta Clara, US
Dr. Mario Paniccia(Co-Founder and CEO)
Co-investorsCatapult VenturesIronGate Capital AdvisorsLockheed Martin VenturesHCVCIn-Q-TelMESH+1 more
BiotechWest Lafayette, US
John J. Turek(Executive Officer)David D. Nolte(Executive Officer, Director)Ted Schenberg(Executive Officer)Travis Morgan(Executive Officer)
Ansa provides an enzymatic DNA synthesis platform that directly synthesizes complex sequences up to 900 bp and delivers constructs up to 50 kb without assembly-based methods.
BiotechDeep TechHealthtechEmeryville, US
Dan Lin-Arlow(Founder)inSebastian Palluk(Founder)inDaniel Lin-Arlow(Executive Officer, Director)Daniel Hillel Lin-Arlow(Executive Officer, Director)Jason T. Gammack(Executive Officer, Director)
BoardYanniv Dorone(Director)
Co-investorsCarbon SiliconDauntless VenturesFifty YearsMetaplanetY CombinatorFall Line Capital+3 more
Antithesis Foods develops and manufactures better-for-you snack products—such as high-protein crackers, pita chips, and gluten-free cookies with added fiber and low sugar—for retailers, DTC brands, and private label clients.
Advanced ManufacturingConsumerFoodTech
Jason(CEO)Ashton(COO)
Anu develops indoor growing systems—including compostable Seedpods, countertop Growpods, and shipping-container aeroponic farms—that let consumers grow pesticide-free produce at the point of consumption.
AgTechConsumerHardware
Co-investorsElevate Ventures
AOSense designs and manufactures atom-optic quantum sensors, including atomic clocks, gyroscopes, accelerometers, gravimeters, and gravity gradiometers, using cold-atom and atomic spectroscopy techniques.
Deep TechHardwareQuantum Computing
Brenton YoungMark KasevichJim Spilker(Chairman)
Co-investorsCentral Texas Angel NetworkThe Launch Place
ApertureDB is a data management product purpose-built for large-scale multimodal data (images, videos, documents) and their metadata, designed for data science and machine learning workflows.
AI & Machine LearningData & InfrastructureDeveloper Tools
Co-investorsGenerationshipGraph VenturesTq Ventures Llc2048 Ventures
Applied Impulse develops impulse-driven manufacturing technology that launches materials at high speed—using methods such as exploding-wire vaporization, electromagnetic solenoid force, and pulsed-laser ablation—to weld, repair, and build metallic parts.
Advanced ManufacturingDeep TechHardware
Applied Particle Technology develops air quality sensors and AI-driven analytics platforms for industrial operations monitoring.
AI & Machine LearningCleantechHardwareIoTSaaSWellness & FitnessSt. Louis, US
Jiaxi Fang(Chief Executive Officer)inTandeep Chadha(Chief Technology Officer)inPratim Biswas(Chief Scientific Officer)in
Co-investorsCapital InnovatorsTechstars
ATFI (Applied Thin Films, Inc.) develops high-temperature ceramic materials, composites, and surface-engineered coatings based on its Cerablak technology, including ultra-thin glassy films, high-temperature sealants, and oxide-oxide ceramic matrix composites.
CleantechDeep TechNew Materials
AppScale provides AWS API-compatible software that lets organizations run AWS workloads' core APIs in their own data centers or private environments at reduced cost.
Cloud ComputingData & InfrastructureEnterprise SoftwareSanta Barbara, US
Woody Rollins(Founder)inEdward C. Rollins, II(Executive Officer, Director)Navraj Chohan(Director)
Apptronik builds humanoid robots designed to perform repetitive, physically taxing, and dangerous tasks in warehousing and manufacturing environments, aiming to free workers for higher-value activities.
Advanced ManufacturingAI & Machine LearningHardwareRoboticsAustin, US
Jeff Cardenas(CEO)Jeffery Lee Cardenas(Executive Officer, Director)Nicholas Arden Paine(Executive Officer, Director)
BoardClarence Gordon Daugherty, IV(Director)Howard Lee Morgan(Director)inGeorge Samuel Rose(Director)
Co-investorsAssembly VenturesAtinum Investment Co. Ltd.B Capital GroupB4 CapitalBaseTwoBig Brain Holdings+22 more
Browse all 2,316 investments with full details →
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TechnologiesCOASTALOCEANVISION, INCCOBIO DIAGNOSTICS INC.CoCoPIECOGNII, INC.COGNITA LABS, LLCCOGNITECH CORPORATIONCognitive Medical Systems, Inc.COGNITIVE ROBOTICS LLCCOLLAMEDIX INCCOLORADO ENGINEERING INC.Colowrap, LLCComake, Inc.COMBUSTION RESEARCH & FLOW TECHNOLOGY INCCOMMET LLCCOMON SOLUTIONS LLCCompact Membrane SystemscompletionAI LLCCOMPOSITE TECHNOLOGY DEVELOPMENT, INC.COMPUTATIONAL TEXTILES, INC.CONAGEN INC.Concepts NREC, LLCCONCURRENT WIRELESSCONNECT DYNAMICS, INC.Connected Wise LLCCONNORA TECHNOLOGIESCOnovateConox, LLCConsortiEXConstrukts, Inc.Contect, Inc.CONTINUUM DYNAMICS INCContinuus PharmaceuticalsCONTROLPOINT INCCONVERGENT ENGINEERING, INC.CoolCAD ElectronicsCOOLCOMPOSITES, INC.CoraviemedicalCordance MedicalCoreshellCORINNOVA, INC.Cornerstone Genomics Inc.CORNERSTONE RESEARCH GROUP INCCorsha WebsiteCORUMAT, INC.CouragionCOUTURE TECHNOLOGIES, LLCCOVARIS, INC.CovaronCovid Cough IncCREARE LLCCREATHADH ENERGIES LLCCREATV MICROTECH INCCroptixCross Cultured Foods PBCCROSSLIFE 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A. 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LLCHummingbird NanoHUMMINGBIRD PRECISION MACHINE CO.HUUE, INC.HYDRONALIX INCHYPERSOUND MEDICAL, INC.HYPHAE DESIGN LABORATORY LLCHYPRES INCHyprLift, Inc.I5 TECHNOLOGIES INCIAMBICIaso TherapeuticsIballistix, LLCIBC ADVANCED TECHNOLOGIES, INCIBEAM MATERIALS, INC.IBS Caribe, Inc.ICONIUM ENGINEERING COMPANYIctero MedicalIDEA51, LLCIdeation Systems, LLCIDEM, LLCIERION, INC.IFYBER LLCIGNEOUS IP HOLDINGS LLCIKONA INCILLIAC SOFTWARE, INC.Imagars LLCImagen Energy LLCIMAGINESTICS, LLCImaging Systems Technology, Inc.Imbed BiosciencesImmersed GamesImmunant, Inc.Impactivo , LLCIMPRESSIO INCIMPULSE TECHNOLOGY LLCImpulsonic, Inc.InanovateINCEPTION ROBOTICS, LLCINCOM, INC.Indrio TechnologiesINDUSTRIAL ANALYTICS & MODELING INCINDUSTRIAL MEASUREMENT SYSTEMS INCIndustrial MicrobesINFERLINK CORPInfinite Composites TechnologiesINFINITY PHYSICS, LLCINFINIUM, INC.INFINUT SOFTWARE INCINFLUIT ENERGY LLCInformAIINFORMATION SYSTEMS LABORATORIES INCINFRASTRUCTURE ANALYTICS COMPANYInfusenseINITWEATHER, LLCInkbitInkSpace ImagingInnavascINNERSPEC TECHNOLOGIES, INC.InnoblativeINNOCIT LLCINNOGIZED TECHNOLOGIES, INC.INNOSENSE CORPORATIONINNOTECH SYSTEMS LLCInnotronics LLCInnovas Technologies, LLCINNOVASONIC, INC.Innovation Accelerator, Inc.INNOVATIVE DYNAMICS INC.INNOVATIVE SCIENTIFIC SOLUTIONS INCINNOVATIVE TECHNOLOGY INCINNOVBOT LLCINNOVISION LLCInnSight Technology, Inc.INNSIGHTFUL INCINQUIRY TECHNOLOGIES, LLCINREDOX LLCInsight Sensing CorporationInsightFinderINSILICA LLCINSILICOM LLCInso BioInstapath Inc.INSU HEALTH DESIGN, INC.IntabioINTACT SOLUTIONS, INCIntact TherapeuticsINTEGRATED ADAPTIVE APPLICATIONS, INCINTEGRATED CONSTRUCTION ENTERPRISES INCIntegrative Economics, LLCIntelinAir | AGMRIINTELLERCE LLCIntelligent Composites LLCIntelligent Dots LLCINTELLIGENT FIBER OPTIC SYSTEMS CORPINTELLIGENT OPTICAL SYSTEMS, INC.INTELLIGENT PROSTHETIC SYSTEMS, LLCIntensivateIntentionetInterphase Materials, Inc.INTERSPHERE INCInterstellar Inc.INTHEPENDANT INCIntuiTap MedicalInvenioINVENT-ABLING LLCInvictus Medical, Inc.Inview Technology CorporationINVVAX INCINXSOL LLCINZIO, INC.Ion DxION POWER, INCIONICSCALE LLCiotaMotionIotashomeIria Pharma, LLCIRIS AO, INC.Iris Light TechnologiesIrradiantIrvine SensorsIS3D LLCISCA TECHNOLOGIES, INC.ISOLERE BIO INCiSono HealthItasca Consulting Group, Inc.ITN ENERGY SYSTEMS, INC.ITOMOGRAPHY CORPORATIONiVeena Delivery SystemsiWalk, Inc.iXpressGenesJade TherapeuticsJeeva WirelessJet-Set Offset, LLCJKM TECHNOLOGIES, LLCJoylabz LLCJP LABORATORIES INCJulia ComputingJuneBrainJunoraltdJUXTOPIA, LLCK&A WIRELESS, LLCK2 OLED LLCKalion Inc.KampanicsKANDRA LABS, INC.KAPALYA INCKarios Technologies, LLCKATZ WATER TECHNOLOGIES, INC.KCF TECHNOLOGIES, INC.Kcore Analytics LLCkeen homekelaHealthKenai Design, LLCKent Optronics, Inc.KEPLER DIAGNOSTICS, INC.KESTREL TECHNOLOGY LLCKIKO LABS INC.Kilele HealthKILLER SNAILS LLCKINETICA LABS, INC.KINETICCORE SOLUTIONS LLCKingdom SuperculturesKino Biosciences, Inc.KintsugihealthKITEFARMS LLCKITWARE INCKlar 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BIOSOLUTIONS, LLCMANTIS COMPOSITES INCManus BioMANUS ROBOTICS INCMAP-COLLECTIVE, INC.Maple MaterialsMaplessMargikMARI, LLCMarigold HealthMarley Environmental IncMarqMetrixMARWELL BIO INCMASSTECH, INC.Materials and Systems Research, Inc.MATERIALS ENGINEERING AND TECHNICAL SUPPORT SERVICES CORP.MATERIALS MODIFICATIONS INCMATERIALS SCIENCES LLC
Exits · 7
IPOs and acquisitions across the tracked portfolioArcadia BiosciencesNASDAQ: RKDAAzitraNYSE: AZTRGinkgo BioworksNYSE: DNAInfleqtionNYSE: INFQOragenicsNYSE: OGENSenti BiosciencesNASDAQ: SNTISolid PowerNASDAQ: SLDP
Portfolio news
latest coverage across their companies3DEO · 3dprint.com · Aug 21, 2026

Eden · barbadostoday.bb · Aug 20, 2026
Rebound · forbes.com · Aug 17, 2026
Qunnect · prnewswire.com · Aug 13, 2026

Remedium · longevity.technology · Aug 10, 2026
Labby · today.lorientlejour.com · Jul 31, 2026
Senti Biosciences · kalkine.com.au · Jul 31, 2026
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- National Science Foundation focuses on AI & Machine Learning, Biotech, Cleantech, Climate Tech, Crypto & Web3, Deep Tech, Energy, New Materials, Quantum Computing.
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- National Science Foundation is headquartered in Alexandria, US.
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Co-investors · 42
DCVC (Data Collective) is a deep tech venture capital firm that backs entrepreneurs using computational approaches to solve large-scale real-world problems across many industries.
Khosla Ventures is a venture capital firm that invests in early-stage companies focused on technology, mobile, and clean energy sectors, including biotechnology applications. The firm provides capital and strategic support to entrepreneurs developing breakthrough technologies across multiple markets.
Ulu Ventures is a seed-stage venture capital firm focused on finding and funding early-stage founder teams, emphasizing diversity and data-driven investment decisions.
Lux Capital is a venture capital firm that backs founders building transformative deep technologies, having been among the first investors in category-defining companies across AI, robotics, biotech, defense, and infrastructure.
11.2 Capital is a venture capital firm that invests in founders addressing major global challenges.
Menlo Ventures is a venture capital firm that invests in transformative, early-stage AI companies across every layer of the modern AI stack, from applications and middleware to data infrastructure and foundation models.
Andreessen Horowitz (a16z) is a venture capital firm founded in 2009 by Marc Andreessen and Ben Horowitz, known for pioneering the platform model with a large team of operators supporting founders across stages.
Craft Ventures is a venture capital firm founded and run by former founders and operators who partner with founders to help build and scale technology companies.
Bessemer Venture Partners is a global venture capital firm that partners with entrepreneurs across enterprise, consumer, and healthcare sectors from early stages through growth.
CRV (Charles River Ventures) is an early-stage venture capital firm that backs founders leading seed and Series A rounds, having invested for over 55 years since its 1970 founding.
Reach Capital is an early-stage venture firm that partners with founders building companies in learning, health, and work.
VoLo Earth Ventures is a climate-focused venture capital firm investing in low-carbon energy, sustainable connectivity, smart buildings, and industrial decarbonization technologies.
▶30 more co-investors
SV AngelBattery VenturesPartech VenturesC2 InvestmentsAfore CapitalFloodgateTodd and Rahul’s Angel FundMaveronUpfront VenturesAwesome People VenturesStandard CapitalKearny JacksonWalden InternationalHOF CapitalIVCSeed Club VenturesHummingbird VenturescLabsSolana VenturesDivergenceGlobal Innovation FundSID Venture PartnersRivet VenturesEthereal Ventures Management Ltd.HashedREMUS CapitalDBL PartnersAgFunderCenter ElectricVertex Ventures HC
Firms observed investing alongside National Science Foundation, from public investor directories. Shared companies are the overlap with National Science Foundation's recorded portfolio.
Similar investors
Khosla Ventures is a venture capital firm that invests in early-stage companies focused on technology, mobile, and clean energy sectors, including biotechnology applications. The firm provides capital and strategic support to entrepreneurs developing breakthrough technologies across multiple markets.
Everywhere Ventures is an early-stage venture firm that backs founders globally, supported by a community of founders and operators as LPs.
Alpha Edison is an investment firm that partners with entrepreneurs to build category-creating companies that open up new markets.
Qbic is an inter-university venture capital fund that turns technological breakthroughs from its partner universities, research institutes and hospitals into sustainable businesses.
Creative Destruction Lab (CDL) is a nonprofit organization that runs an objectives-based mentoring program for seed-stage, science- and technology-based startups, helping founders build massive companies.





























