/Companies

Illuminant Surgical

YC S22

Los Angeles, US · Founded 2021 · 11 employees · 14 known investors

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Illuminant Surgical develops an AI-powered real-time anatomical projection system called Skylight for spine surgery and interventional procedures, using computer vision and projection mapping to display medical imaging directly onto patients. The system is designed for surgical professionals across hospitals, ambulatory surgical centers, and specialty clinics to improve surgical guidance and workflow efficiency.

Also known as Illuminant · Illuminant Surgical

Founders & leadership· Y Combinator alumni (S22)

Illuminant Surgical was founded in 2021 by Eldrick Millares, James Hu, and Jhoneldrick Millares.

EMEldrick Millares
Eldrick MillaresCo-founder · Co-Chief Executive OfficerEldrick Millares holds a BS and MS in Electrical Engineering from Stanford and is a co-founder and co-CEO of Illuminant Surgical.
JHJames Hu
James HuCo-Founder, Co-Chief Executive OfficerJames Hu studied bioengineering at Stanford and holds a medical degree from UCI. He is co-founder and co-CEO of Illuminant Surgical.30 Under 30 2026
JM
Jhoneldrick MillaresCofounder30 Under 30 2026
BN
Brian NguyenMechanical Engineering
EO
Enoch OmaleSoftware Engineering
JG
Joseph GuSoftware Engineerformer

Investors · 14

Also in the syndicate · 4

DRFElderberry VenturesNational Cancer InstituteNational Institute on Aging

Funding

SEC filings, press & company announcements

$16.8M disclosed across 2 of 3 rounds · 2026

Source: company announcements and press reports — follow each round's link for the claim.

Company profile

researched Aug 2026

Illuminant Surgical is a Los Angeles-based medical technology company developing Skylight, described by the company as the first real-time anatomical projection system for spine surgery and interventional access. Rather than presenting medical images on a separate monitor, Skylight projects imaging directly onto the patient's body so the clinician can see a representation of underlying anatomy at the procedure site. The system includes a patient registration method the company calls SkinMatch, and the company states it can be set up non-invasively within minutes and used after roughly one day of training.

The company frames its work around three problems with conventional surgical navigation: the cognitive burden of shifting attention between screens and the patient while mentally translating 2D scans into 3D anatomy; workflow complexity, including setup times the company says often exceed 30 minutes and reliance on specialized technical support; and limited access, since advanced navigation has generally been confined to major medical centers because of cost and space requirements. Skylight is positioned as a compact alternative intended for settings ranging from university hospitals to ambulatory surgical centers and private specialty clinics, with applicability to pain management and interventional radiology in addition to spine surgery.

Skylight is at a pre-commercial development stage. The company states that the Skylight Surgical Navigation System has not been approved or cleared by the U.S. Food and Drug Administration and is not available for sale or commercial use, and that no claims are made regarding its safety or effectiveness.

Traction

Following the April 2026 announcement of an $8.4M Series Seed, the company said it had accelerated engineering, manufacturing, and clinical efforts. In June 2026 it opened a new Los Angeles headquarters called the Nexus with a ribbon-cutting attended by more than 130 guests. The product remains pre-FDA clearance and is not offered for sale.

Latest developments

In 2026 the company announced an $8.4M Series Seed round (April), opened its Nexus headquarters in Los Angeles (June), and was scheduled to lead its second frontier workshop at SIGGRAPH 2026 in Los Angeles (June). Earlier in the year, Co-Founder and Co-CEO James Hu presented at NVIDIA GTC 2026, and Co-Founder and Co-CEO Eldrick Millares was featured in LSI's The Memo and The Lens Magazine.

▸Full profile — market position, technology, go-to-market, geography, history, risks & controversies

Market position

Illuminant Surgical positions Skylight against traditional surgical navigation systems, which it characterizes as costly, space-intensive, slow to set up and largely restricted to large medical centers, and instead targets broad applicability across procedure settings and specialties.

Direct projection of anatomical imaging onto the patient instead of screen-based navigation; SkinMatch non-invasive patient registration; setup measured in minutes rather than the 30-plus minutes the company attributes to conventional systems; a compact form factor intended for smaller facilities; and a stated one-day training requirement.

Technology

Skylight combines artificial intelligence, computer vision, and dynamic projection mapping to overlay imaging onto the patient in real time, aiming to merge digital guidance with the physical operative field. A registration technology branded SkinMatch aligns imaging to the patient. The company emphasizes a compact hardware footprint that fits into standard procedure rooms and a non-invasive setup process completed in minutes, in contrast to navigation systems requiring invasive patient preparation and longer setup.

Go-to-market

The company markets through its website with a demo booking request, and builds visibility through medtech and technical community channels, including LSI newsletter and magazine features, a presentation at NVIDIA GTC 2026, and company-led workshops on graphics in medicine at SIGGRAPH.

Physicians performing image-guided procedures, including spine surgeons and interventionalists in pain management and interventional radiology, across care settings that range from university hospitals to ambulatory surgical centers and private specialty clinics.

Geography

Headquartered in Los Angeles, California, at 2440 S Sepulveda Blvd, Ste 125, with company events held in Los Angeles.

History

The company is led by Co-Founders and Co-CEOs Eldrick Millares and Dr. James Hu. It has assembled a board of advisors spanning clinical, engineering, and business domains, including spine surgeons Jeffrey Wang, MD (President, AO Foundation; Co-Director of the USC Spine Center) and John Liu, MD (Professor of Neurological Surgery; Co-Director of the USC Spine Center); engineering advisors Ross Venook, PhD (Engineering Director, Stanford Biodesign) and Christoph Leuze, PhD (Executive Director, Stanford Medical Mixed Reality Lab); and business advisors Joe Kiani (CEO, Willow Labs; founder of Masimo), Brad Smith (President, Marshall University; former CEO of Intuit), Shyam Natarajan, PhD (CEO, Avenda Health), and Brian Hess, MBA (CEO, RevBio; former Stryker Ortho director). Company milestones through 2026 include LSI features, a presentation at NVIDIA GTC, an $8.4M seed round, a new Los Angeles headquarters, and SIGGRAPH workshops.

Risks & controversies

The Skylight Surgical Navigation System has not been approved or cleared by the FDA and is not available for sale or commercial use; the company states that no claims are made regarding the device's safety or effectiveness and that website information reflects current development stage and intended capabilities. The company also publishes a financial conflict of interest (FCOI) policy.

Compiled by commissioned research from 1 cited public sources — announcements, filings, and press listed under research sources below.

Key figures

latest reported
HeadcountAug 202621
Stated training requirement for SkylightJan 20261 day

Company-reported or press-reported figures, each dated to when it was claimed — not independently audited.

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Companies working in the same space as Illuminant Surgical.

Timeline · 6

launches, deals, and filings
Jun 2026
Second frontier workshop at SIGGRAPH 2026

The company was set to lead its second frontier workshop at SIGGRAPH 2026 in Los Angeles, following an earlier SIGGRAPH workshop titled 'Graphics in Medicine: From the Dev Floor to...'.

source ↗

Jun 2026
Ribbon cutting for new Los Angeles headquarters, the Nexus

Illuminant Surgical held its first official launch party and ribbon cutting ceremony for the Nexus, its new company headquarters in Los Angeles, with over 130 guests including advisors, friends and family.

source ↗

Apr 2026
Illuminant Surgical announces $8.4M Series Seed round

The company announced an $8.4M Series Seed round, which it said was covered in Fortune by Allie Garfinkle, and stated the proceeds were being used to accelerate engineering, manufacturing, and clinical efforts.

$8.4M source ↗

Mar 2026
Co-CEO James Hu presents at NVIDIA GTC 2026

Co-Founder and Co-CEO Dr. James Hu presented the company's work at NVIDIA GTC 2026, an event the company described as having over 30,000 attendees.

source ↗

Feb 2026
Eldrick Millares featured in LSI Alumni Innovator Spotlight

Co-Founder and Co-CEO Eldrick Millares was featured in the Innovator Spotlight of The Lens Magazine, published by LSI (Life Science Intelligence).

source ↗

Jan 2026
Company profiled in LSI's The Memo newsletter

Co-Founder and Co-CEO Eldrick Millares was featured in The Memo, Life Science Intelligence's newsletter and insights series covering emerging medtech companies and market trends.

source ↗

Dated company events from announcements, filings, and press; legal rows summarize public dockets and regulator releases.

Legal entities · 1

corporate structure
Illuminant Surgical, Inc.

In the news

▸Research sources · 1

primary sources listed

1 public sources were cited for this profile; the first-party ones are listed here.

Frequently asked questions

What does Illuminant Surgical do?
Illuminant Surgical builds Skylight, a real-time system that projects anatomical imaging onto patients during spine and interventional procedures.
Who founded Illuminant Surgical?
Illuminant Surgical was founded by Eldrick Millares, James Hu, Jhoneldrick Millares in 2021.
Who are Illuminant Surgical's investors?
Illuminant Surgical's investors include Dorm Room, Flucas Ventures, Kube VC, Soma Capital, Y Combinator, Alumni Ventures, Asymmetry Ventures, Golden Gate Ventures and 2 more.
How much funding has Illuminant Surgical raised?
Illuminant Surgical has disclosed $16.8M raised across 2 of its 3 known rounds.
Where is Illuminant Surgical headquartered?
Illuminant Surgical is headquartered in Los Angeles, US.