Lightstone Ventures — Full Portfolio

Shoulder Innovations develops InSet® glenoid technology for shoulder joint implants that reduce the rocking horse effect and provide mechanical stability, serving patients with severe shoulder arthritis.

HardwareHealthtechMedical DevicesNorthern California, US

RBRobert Ball(CEO & Executive Chairman)MAMatthew Ahearn(Chief Operating Officer)inJPJeff Points(Executive Officer)inDon Running(Manager and Chief Executive Officer)Jeff Ondrla(Chief Technology Officer)DLDavid L. Blue(Chief Customer Experience Officer)in

Board seatMCMike Carusi· per SEC Form D

Co-investorsALAlumni VenturesAPAPERTURE Venture PartnersARArboretum VenturesGEGenesis Innovation GroupGLGlobal BrainINInvest Michigan+3 more

Verastem Oncology is a biopharmaceutical company that discovers and develops drugs to treat cancer patients.

BiotechMedical DevicesNeedham, US

RWRobert WeinbergRICHARD ALDRICH(Director)ACAMY C. CAVERS(Executive Officer)inCCCATHY CAREW(Executive Officer)inJPJONATHAN PACHTER(Executive Officer)inRGROB GAGNON(Executive Officer)in

Co-investorsBEBessemer Venture PartnersCACardinal PartnersFOForesite CapitalLOLongwood FundOBOberland CapitalVIViking Global+1 more

Contego Medical develops the Neuroguard IEP System, a 3-in-1 carotid stenting device combining a carotid stent, dilation balloon, and integrated embolic protection with a 40-micron filter to reduce stroke and cognitive impairment from microembolization.

HardwareHealthtechMedical DevicesRaleigh, US

RSRavish Sachar(CEO & Founder)Paul Sanders(Chief Operating Officer)

Board seatHSHanson S. Gifford, III· per SEC Form D

Co-investorsHAHatteras Venture PartnersAMAmzak HealthMOMountain Group CapitalUSUS Venture Partners

PsiThera is a biotechnology company using computational and physics-based methods—including quantum mechanics, molecular dynamics, machine learning, and simulation—for mechanism-driven drug design and discovery.

AI & Machine LearningBiotechDeep Tech

Co-investorsSASamsara BioCapital

Vesper Medical develops a modular venous stent portfolio designed to address the anatomical challenges of the iliac and femoral veins for treating deep venous disease.

HealthtechMedical DevicesWayne, US

BJBruce J. Shook(President and CEO)MKMonica Klos(Executive Officer)inNHNeil Hattangadi(Director)inPeter Schneider(Director)Mark Garcia(Director)Dennis W. Wahr(Director)

Co-investorsNENew Enterprise Associates (NEA)GIGilde HealthcareVEVensana Capital41415 Capital

Allay Therapeutics develops localized pain management technology designed to deliver several weeks of post-surgical pain relief.

BiotechHealthtechMedical DevicesSan Jose, US

AGAdam Gridley(Executive Officer, Director)inKristen Howells(Executive Officer)inJosh Makower(Director)Tak Cheung(Director)inKarun D. Naga(Executive Officer, Director)

BoardLeighton Read(Director)

Board seatMichael A. CarusiHSHanson S. Gifford, III· per SEC Form D

Co-investorsARArboretum VenturesNENew Enterprise Associates (NEA)SGSGInnovateVEVertex Ventures HCCLClavystBioEVEvonik Venture Capital GmbH

Apreo Health develops a bronchoscopic treatment for severe emphysema using a self-expanding airway scaffold designed to reduce trapped air and improve lung function.

BiotechHealthtechMedical DevicesMenlo Park, US

Karun Durgam Naga(Executive Officer, Director)

BoardHanson S. Gifford III(Director)ZSZack Scott(Director)inDFDrew Field(Director)inDMDennis McWilliams(Director)in

Board seatHSHanson S. Gifford, IIIMichael A. Carusi· per SEC Form D

Co-investorsF-F-Prime CapitalINIntuitive VenturesNONorwest Venture PartnersSTStar51 CapitalBABain Capital Life Sciences

Cala Health develops non-invasive prescription therapies for movement disorders, starting with a treatment for hand tremor and essential tremor.

Deep TechDigital HealthHealthtechMedical DevicesSilicon Valley, US

KRKate Rosenbluth, PhD(President & Chief Innovation Officer)KRKate Rosenbluth(Founder)inDHDeanna Harshbarger(Founder)in

Board seatMichael A. Carusi· per SEC Form D

Co-investorsALAlumni VenturesASAscension VenturesDODolby Family VenturesGLGlobal BrainGVGV (Google Ventures)LILifeSci Venture Partners+5 more

FemTechHealthtechMedical DevicesRedwood City, US

Christopher Owens(Executive Officer, Director)Darrin Uecker(Executive Officer, Director)

BoardKen Haas(Director)JMJonathan MacQuitty(Director)inDoug Fisher(Director)

Board seatMCMike Carusi· per SEC Form D

Co-investorsAMAmzak HealthBABain Capital Life SciencesENEndeavour VisionFEFemHealth VenturesKAKaiser Permanente VenturesKLKluz Ventures+6 more

Imperative Care develops medical technologies for treating stroke and other vascular diseases, aiming to address gaps across the patient care journey.

HealthtechMedical DevicesCampbell, US

Farhad Khosravi(Executive Officer, Director)MGMatthew Garrett(Executive Officer)inCharles Alpuche(Executive Officer)SEScott Elliott(Executive Officer)in

BoardJames Rogers(Director)SEStacy Enxing Seng(Director)

Board seatHenry Albert Plain, Jr.· per SEC Form D · $100M raise · filed Mar 2026

Co-investorsASAscension VenturesBABain Capital Life SciencesCACatalio Capital Management, LPDEDelos CapitalFEFemHealth Ventures

Nuvaira develops the dNerva Lung Denervation System, a catheter-based device used in a one-time, outpatient bronchoscopic procedure that disrupts pulmonary nerve input to treat chronic obstructive pulmonary disease (COPD).

HardwareHealthtechMedical DevicesMinneapolis, US

MMMartin Mayse(Founder)inSDSteve Dimmer(Founder)inDWDennis Wahr(President & CEO)inLFLisa Flaherty(Chief Strategy Officer)inSSSteve Sathre(Vice President of Finance)inSteve Paidosh(Vice President of Operations)

Board seatMichael A, CarusiHenry PlainMichael A. CarusiMCMike CarusiHPHank Plain· per SEC Form D

Co-investorsWIWindham Capital PartnersENEndeavour VisionMOMorgenthalerQIQiming Venture PartnersRIRichard King Mellon FoundationSPSplit Rock Partners+2 more

HealthtechBelmont, US

Barry Cheskin(Executive Officer, Director)S. Arieh Zak(Executive Officer)George Green(Executive Officer)

BoardDrew Schiff(Director)Lou Bock(Director)

Board seatMichael Carusi· per SEC Form D

Co-investorsAIAisling CapitalARArcher Capital GroupARArcher Venture CapitalFRFrazier Life SciencesJOJohnson & Johnson Innovation – JJDCSCScale Venture Partners

Reprieve Cardiovascular develops a decongestion management system that uses real-time patient data to guide and personalize diuretic therapy for fluid removal in heart failure patients.

Digital HealthHealthtechMedical DevicesMilford, US

TFTony Fields(Executive Officer)ABAdam Bartnik(Executive Officer)inMark Pacyna(Executive Officer, Director)inJim Dillon(Executive Officer, Director)Hanson S. Gifford III(Director)Gregory W Mann(Executive Officer)

Board seatHSHanson S. Gifford, III· per SEC Form D

Co-investorsARArboretum VenturesRERex Health VenturesDEDeerfield Management CompanyGEGenesis Venture CapitalSASante Ventures

Tangible Science develops contact lens solutions designed to improve comfort and durability for wearers and to provide eye care professionals with more effective treatment options.

HealthtechMedical DevicesMenlo Park, US

KHKaren Havenstrite(Director)inVMVictor McCray(Executive Officer, Director)

BoardDCDouglas Crawford(Director)inHGHanson Gifford(Director)inChip Heath(Director)Brandon Felkins(Director)

Board seatHSHanson S. Gifford, III· per SEC Form D · $4.6M raise · filed Nov 2016

Co-investorsMIMission BiocapitalSHShangBay Capital LLC

Twelve transforms CO2 into chemicals, fuels, and materials through carbon transformation technology.

Advanced ManufacturingCleantechClimate TechHealthtechNew MaterialsMoses Lake, US

NFNicholas Flanders(Founder)inECEtosha Cave(Founder)inKendra Kuhl(Founder)inACAndrew Cleeland(Executive Officer, Director)in

BoardMarc-Henri Galletti(Director)Nimesh Shah(Director)

Board seatHSHanson S. Gifford, IIIHenry A. Plain, Jr.· per SEC Form D

Co-investorsBRBreakout VenturesDCDCVC (Data Collective)DODolby Family VenturesFIFifth WallADAdvantage Partners Inc.AEAera VC+37 more

65LAB accelerates drug discovery and therapeutic company formation by connecting academic research institutions, life science investors, and Evotec to develop novel medicines into commercial entities.

BiotechDeep TechSingapore, SG

BoardSteve Courtney(Expert in Residence)

Co-investorsCLClavystBioLELeaps by Bayer

A pharmaceutical company that develops medicines and vaccines for patients globally.

BiotechHealthtechMedical DevicesCambridge, US

WYLIE W. VALE(Director)JKJOHN KNOPF(Executive Officer, Director)STEVEN ERTEL(Executive Officer)RSROBERT STEININGER(Executive Officer)inKEVIN F. MCLAUGHLIN(Executive Officer)inMLMATTHEW L. SHERMAN(Executive Officer)

Co-investorsBEBessemer Venture PartnersFOForesite CapitalHEHercules Capital, Inc.LOLowercarbon CapitalSOSofinnova VenturesVEVenrock+1 more

Alchemab operates a platform that identifies novel drug targets and therapeutics by analyzing patient antibody repertoires using deep B cell sequencing and computational analysis of samples from disease-resilient individuals.

AI & Machine LearningBiotechDeep TechHealthtech

JOJane Osbourn(Founder)Young Kwon(Founder)

Co-investorsRARA CapitalSVSV Health InvestorsDCDCVC BioDEDementia Discovery FundONOno Venture Investment, Inc.BRBritish Business Bank+3 more

Amber Therapeutics develops medical technology focused on treating mixed urinary incontinence, advancing toward pivotal clinical trials in the US with expanded feasibility studies in Europe.

Medical Devices

Co-investorsF-F-Prime CapitalINIntuitive VenturesNENew Enterprise Associates (NEA)OXOxford Science Enterprises

Atsena Therapeutics is a clinical-stage gene therapy company developing treatments for inherited retinal diseases that cause vision loss.

BiotechDeep TechMedical DevicesAustin, US

Co-investorsWEWellington ManagementHAHatteras Venture PartnersSOSofinnova Ventures

BiotechTV is a media outlet producing video shows, event coverage, and news focused on the biotech and healthcare sectors, including topics like venture funding, oncology conferences, and drug development.

BiotechMedia & Entertainment

BLBrad Loncar(Founder)in

Bird is an omnichannel communications CRM platform that connects businesses with their customers across channels including SMS, voice, WhatsApp, WeChat, Messenger, and email.

AI & Machine LearningCloud ComputingDeveloper ToolsEnterprise SoftwareMarketing TechSaaSAmsterdam, NL

RVRobert Vis(Founder & CEO)inBVBob Violier(Distinguished Engineer)inJVJoey van Ommen(Head of Product \u0026 Partner)inAMAdriaan Mol(Founder)in

Co-investorsACAccelANAnthem Venture Management, LlcATAtomicoBLBlue LionBLBlue Lion GlobalGLGlynn Capital Management+15 more

Bonito develops encoded library and live-cell selection technologies to discover delivery ligands, generating high signal-to-noise data on membrane-bound targets to train AI models for precision drug delivery.

AI & Machine LearningBiotechDeep Tech

RWRichard Wagner(CEO, Cofounder)in

Co-investorsJAJAZZ Venture Partners

Cardiac Booster develops cardiac support technology for use in treating heart conditions.

BiotechHardwareHealthtechMedical DevicesGalway, IE

FLFlorian Ludwig(CEO)inGKGerard Kilcommins(COO)inGreg Mann(CFO)PGPatrick Griffin(VP Technology Development)inJGJeff Grainger(VP of Legal Affairs)inDMDaragh Moloney(HR Director)in

Co-investorsASAscension VenturesTHThuja Capital

Carrick Therapeutics is a biopharmaceutical company with a leadership team experienced in oncology drug development and commercialization.

BiotechDigital HealthHealthtechMedical DevicesBoston, US

TPTimothy Pearson(CEO)ABAsh Bahl(CSO)inJHJenny Horsfield(CBO)inSMStuart McIntosh(CMO)inDSDavid Sutherland(VP Finance & Controller)

Co-investorsARARCH Venture PartnersB B Capital GroupB4B4 CapitalCACambridge Innovation CapitalGVGV (Google Ventures)RERevelation Partners+2 more

BiotechCambridge, US

Jill C. Milne(Executive Officer, Director)inIan Sanderson(Executive Officer)in

BoardRon Laufer(Director)Nicholas Galakatos(Director)inJGJean George(Director)Michael Ross(Director)

Co-investorsCLClarus Ventures

Catamaran Bio develops allogeneic CAR-NK cell therapies for cancer treatment, focusing on solid tumors, by combining natural killer (NK) cell biology with synthetic biology and non-viral cell engineering.

BiotechHealthtech

BMBranden Moriarity(Scientific Co-founder)Catherine Bollard(Scientific Co-founder)

Co-investorsASAstellas Venture Management LLCSOSofinnova Partners

Cerevance develops precision novel therapeutics for central nervous system disorders, particularly neurodegenerative diseases, using its proprietary NETSseq platform and machine learning to identify targets from an extensive collection of human brain tissue samples.

AI & Machine LearningBiotechDeep TechHealthtechMedical DevicesBoston, US

CTCraig Thompson(Chief Executive Officer)inSVSagar Vaidya(Chief Medical Officer)inCarrie Ann Cook(Chief Business Officer)MCMark Carlton(Chief Scientific Officer)inOVOttavio V. Vitolo(Chief Medical Officer)in

Co-investorsDEDementia Discovery FundFOForesite CapitalGVGV (Google Ventures)SVSV Life SciencesDEDementia DiscoveryDODolby Family Ventures+4 more

HealthtechSanta Rosa, US

Fred Khosravi(Director)Tony Fields(Executive Officer)

BoardJames Eadie(Director)APAzin Parhizgar(Executive Officer, Director)inHenry A. Plain(Director)Leo Nelson Hopkins(Director)

Co-investors41415 CapitalEAEaston CapitalMOMorgenthalerSASante Ventures

CoolSculpting offers FDA-cleared body-contouring procedures that use controlled cooling to reduce visible fat bulges in areas such as the chin, abdomen, thighs, and flanks, along with the CoolTone device for muscle strengthening and toning.

HealthtechMedical DevicesWellness & Fitness

Co-investorsAIAisling Capital

Crystalys Therapeutics is a clinical-stage biopharmaceutical company developing targeted therapies for gout, a chronic metabolic disease caused by elevated uric acid.

BiotechHealthtechMedical DevicesSan Diego, US

JMJames Mackay(President & Chief Executive Officer)inNihar Bhakta(Chief Medical Officer)inAshwin Ram(Chief Operating Officer)inDeAnne Reid(Chief Administrative Officer)in

Co-investorsCACatalys PacificNONovo HoldingsANAN Venture PartnersFRFrazier Life SciencesLOLongwood FundPOPontifax Venture Capital

Curie.Bio is a biotech venture firm pairing seed capital with in-house drug discovery support for therapeutics founders.

ZWZach Weinberg(Founder)inAlexis Borisy(Founder)Christoph Lengauer(Founder)

Co-investorsALAlleyCorpARARCH Venture PartnersBOBoxGroupDNDNA CapitalF-F-Prime CapitalGVGV (Google Ventures)+5 more

Cyteir is a clinical-stage oncology company developing CYT-0851, an oral investigational drug that inhibits monocarboxylate transporters.

BiotechHealthtechCambridge, US

Kevin Mills(Executive Officer, Director)inRGRonald Goldstein(Executive Officer)inDCDonald Corcoran(Executive Officer, Director)inMRMarkus Renschler(Director)in

BoardTimothy Romberger(Director)Barry Mills(Director)

Co-investorsDRDroia VenturesOUOUP (Osage University Partners)SHShah Family OfficeALAlly Bridge GroupDEDe Novo VenturesJAJanus Henderson Investors+3 more

Earlens makes a hearing aid that vibrates the eardrum directly rather than using speakers to amplify sound, allowing amplification across a broad audible frequency range including higher frequencies for speech understanding.

HardwareHealthtechMedical DevicesMenlo Park, US

Rodney Perkins, M.D.(Director)William M. Facteau(Executive Officer, Director)Bernard Shay(Executive Officer)Phil Lyons(Executive Officer)BEBrent Edwards(Executive Officer)Greg Koskowich(Executive Officer)

Co-investorsAIAisling CapitalNENew Enterprise Associates (NEA)WIWindham Capital PartnersMOMorgenthalerSISightLine Partners

EndoGastric Solutions offers the Transoral Incisionless Fundoplication (TIF 2.0) procedure and the EsophyX device used to treat GERD, along with reimbursement and technical/administrative support (TAP program) for medical practices.

BiotechHealthtechMedical DevicesSan Mateo, US

Philip Macdonald(Executive Officer)Louis Baldino(Executive Officer, Director)Lilip Lau(Executive Officer)JDJosh DeFonzo(Executive Officer)in

BoardMCMichael Carusi(Director)inArda Minocherhomjee(Director)

Co-investorsACAccelmed PartnersCACanaan PartnersEVEvidity Health CapitalVCVCFA GroupADAdvanced Technology VenturesDEDe Novo Ventures+2 more

FIRE1 develops NORM, an implantable sensor placed in the inferior vena cava to directly measure fluid volume in heart failure patients, paired with a self-management platform to help patients engage with their own care.

Digital HealthHardwareMedical DevicesDublin, IE

Co-investorsANAndera PartnersGIGimvIRIreland Strategic Investment FundLOLongitude CapitalNENew Enterprise Associates (NEA)SESeventure Partners+5 more

Flex Pharma provides accessible generic vasodilator medications, including PDE5 inhibitors, to U.S. patients at lower costs than brand-name alternatives.

BiotechDigital HealthHealthtechMedical Devices

Dr. Rod MacKinnon(Founder)

Co-investorsBEBessemer Venture PartnersECEcoR1 CapitalLOLongwood Fund

Precision medicine company developing therapeutics for genetically-defined age-related macular degeneration.

BiotechCambridge, US

JMJames McLaughlin(Executive Officer, Director)in

BoardJGJean George(Director)JRJason Rhodes(Director)inCGCarl Gordon(Director)in

Co-investorsALAltium CapitalATAtlas VentureOROrbiMed

Hydra provides analytics query execution for Postgres databases with separated compute resources, automatic scaling, and built-in caching, designed for time series and event data workloads across multiple deployment environments.

Data & InfrastructureDeveloper ToolsEnterprise SoftwareSan Francisco, US

JSJoseph Sciarrino(Founder)inJD Dance

Co-investorsY Y Combinator1010X Capital1010x FoundersANAntlerCOComcast VenturesEREra Funds+12 more

BiotechCambridge, US

Magdalene Moran, Ph.D.(Executive Officer)Bert Chenard, Ph.D.(Executive Officer)Russell Herndon(Executive Officer, Director)Tom Burke(Executive Officer)

BoardVincent Miles(Director)JGJean George(Director)

Co-investorsNENew Enterprise Associates (NEA)SASaints CapitalABAbingworthLILilly Ventures

Medisix Therapeutics develops a pipeline of therapeutic products using integrated technology platforms spanning the product lifecycle, supported by a CMC platform for large-scale manufacturing.

BiotechHealthtechSingapore, SG

PDProfessor Dario Campana, MD, PhD(Scientific Founder)Andrew Bruce, BSc(Chief Executive Officer)

Day One (part of Servier) is a biopharmaceutical company developing targeted oncology medicines, with a focus on cancers affecting patients of all ages, including pediatric low-grade glioma (pLGG).

BiotechHealthtechCambridge, US

MICHAEL J. KAUFMAN(Executive Officer)inDonald Bergstrom(Executive Officer)inAPANNA PROTOPAPAS(Executive Officer, Director)TLTimothy Lowinger(Executive Officer)Eva Jack(Executive Officer)Wayne Foster(Executive Officer)

Co-investorsBABain Capital Life SciencesF-F-Prime CapitalNENew Enterprise Associates (NEA)NENextech InvestPFPfizer Venture InvestmentsRHRho Ventures+3 more

Terumo Neuro (formerly MicroVention) develops minimally invasive catheter-based medical devices for treating neurovascular disorders including cerebral aneurysms, ischemic stroke, carotid artery disease, and neurovascular malformations.

Enterprise SoftwareHealthtechMedical DevicesAliso Viejo, US

CSCarsten Schroeder(President and CEO)in

HealthtechFremont, US

Anton Clifford(Executive Officer)inJLJames Leech(Executive Officer)inCGChristopher Gleason(Executive Officer)inKevin K. Sidow(Executive Officer, Director)

BoardJoshua Makower(Director)SMShahzad Malik(Director)in

Co-investorsADAdvent Life SciencesNENew Enterprise Associates (NEA)RURunway Growth CapitalGBGBS Venture Partners Ltd.GIGilde HealthcareMOMorgenthaler+1 more

Nimbus Therapeutics is a biotechnology company that designs precision small molecule medicines using a computational, multidisciplinary drug discovery approach.

AI & Machine LearningBiotechDeep TechHealthtech

Co-investorsACAccess BiotechnologyATAtlas VentureBABain Capital Life SciencesDEDementia Discovery FundGVGV (Google Ventures)PFPfizer Venture Investments+4 more

Portola develops research and investigates new targets, modalities, and technologies to address rare disease challenges for patients and their families.

BiotechDigital HealthHealthtechMedical Devices

Co-investorsBLBluebird VenturesFRFrazier Life SciencesHEHercules Capital, Inc.PRProspect Venture PartnersKHKhosla VenturesNFNFDG

ProVerum is a venture-backed medical device startup developing minimally invasive technologies to treat benign prostatic hyperplasia (BPH).

HardwareHealthtechMedical DevicesDublin, IE

Dr Conor Harkin(Founder)inRNRíona Ní Ghriallais(Founder)in

Co-investorsATAtlantic Bridge VenturesIRIreland Strategic Investment FundMVMVM Life Science PartnersOROrbiMed

UCB (UCB SA/NV) is a publicly listed biopharmaceutical company focused on research and development of medicines for defined patient populations.

BiotechHealthtechCambridge, US

DADouglas A. Treco(Executive Officer, Director)Kerry Black(Executive Officer)inJean-Christophe Tellier(Chief Executive Officer & Chairman of the Executive Committee)Sandrine Dufour(Executive Vice President, Chief Financial Officer)Jean Luc Fleurial(Executive Vice President, Chief Human Resources Officer)Fiona du Monceau(Executive Vice President, Chief Commercial Officer)

Co-investorsNENew Enterprise Associates (NEA)RARA CapitalMOMorgenthaler

Relievant offers the Intracept Procedure, a minimally invasive, FDA-cleared medical intervention designed to relieve chronic low back pain caused by vertebrogenic pain.

Medical DevicesRedwood City, US

Alex DiNello(Executive Officer, Director)

BoardRichard Mott(Director)JKJustin Klein(Director)inBABrent Ahrens(Director)inJason Lettman(Director)John Ryan(Director)

Co-investorsCACanaan PartnersEMEmergent Medical Partners, LLPENEndeavour VisionNENew Enterprise Associates (NEA)MOMorgenthalerVEVensana Capital

Co-investorsLILifeforce CapitalPFPfizer Venture InvestmentsRORoche Venture FundDIDigitalis VenturesMOMorgenthalerSRSR One Capital Management

SetPoint Medical develops an FDA-approved implantable neurostimulation device that stimulates the vagus nerve to reduce inflammation, offering a device-based treatment for adults with moderate-to-severe rheumatoid arthritis who have not responded to biologic or targeted synthetic drugs.

BiotechHealthtechMedical DevicesValencia, US

MSMurthy Simhambhatla(CEO)inDCDavid Chernoff(Chief Medical Officer (MD))YLYaakov Levine(PhD)inRSRohan Seth(Executive Officer)inKevin Tracey(Founder)

BoardBWBlake Wu(Director)in

Co-investorsALAlly Bridge GroupNENew Enterprise Associates (NEA)NONorwest Venture PartnersTOTopspin PartnersASAsahi Kasei Corporate Venture CapitalCACatalio Capital Management, LP+9 more

Tagworks Pharmaceuticals develops cancer therapies using its Click-to-Release platform, a chemical reaction that activates antibody-drug conjugates (ADCs), masked immunomodulators, and other prodrugs on-target while deactivating radioimmunotherapies off-target.

BiotechHealthtechMedical DevicesNijmegen, NL

Co-investorsBIBifNENew Enterprise Associates (NEA)NONovartis Venture FundYSYsios CapitalCLClarus VenturesGIGilde Healthcare+1 more

Tallac Therapeutics is a clinical-stage biopharmaceutical company developing oligonucleotide-based antibody conjugates (TRAAC candidates) designed to deliver immune-activating agents to tumor microenvironments for oncology indications.

BiotechHealthtechMedical DevicesBurlingame, US

HWHong Wan(Executive Officer, Director)in

BoardRan Geng(Director)Michael Carusi(Director)Isaac Cheng(Director)Christine Brennan(Director)CGCorey Goodman(Director)in

Co-investorsMRMRL Ventures FundVEvenBio PartnersMAMatrix Partners ChinaVEvenBio Global Strategic

The Foundry is a medical device incubator that identifies unmet clinical needs and builds companies around new technologies to address them, working with physician collaborators to develop products from concept to market.

BiotechDeep TechHealthtechMedical Devices

Co-investorsNENew Enterprise Associates (NEA)OAOasis Capital

Tizona Therapeutics is a biotechnology company developing first-in-class immuno-oncology therapeutics, including its lead clinical-stage asset TTX-080, aimed at changing cancer progression and relapse.

AI & Machine LearningBiotechHealthtech

VKVijay K. Kuchroo(Scientific Co-Founder & Advisory Board Member)Drew Pardoll(Scientific Co-Founder & Advisory Board Member)Dario Vignali(Scientific Co-Founder & Advisory Board Member)Jedd Wolchok(Scientific Co-Founder & Advisory Board Member)COChristine O'Brien(Chief Executive Officer & Board Member)inCBCourtney Beers(Chief Scientific Officer)

Co-investorsCACanaan PartnersMPMPM BioImpactABAbingworthGIGilead SciencesASAstellas Venture Management LLC

Transcend Medical was a Menlo Park, CA medical-device company spun out of ForSight Labs that developed the CyPass Micro-Stent, a minimally invasive glaucoma implant to reduce intraocular pressure.

HealthtechMenlo Park, US

Wende Hutton(Director)Brian Walsh(Executive Officer, Director)Dan Galles(Director)Jim Glasheen(Director)K. Angela Macfarlane(Director)Robert C. Bellas, Jr.(Director)

Co-investorsCACanaan PartnersLALatterell Venture Partners

Trishula Therapeutics is a clinical-stage biopharmaceutical company developing TTX-030, a first-in-class anti-CD39 antibody for advanced cancers.

BiotechHealthtech

ASAnil Singhal(President and CEO)inSMSiddhartha Mitra(Chief Medical Officer)in

Co-investorsCACanaan PartnersMPMPM BioImpactASAstellas Venture Management LLC

San Diego biotech founded in 2019 developing oral anti-inflammatory small molecules targeting RNA binding proteins.

Co-investorsARARCH Venture PartnersMEMedical Excellence CapitalCACanaan Partners

Urotronic develops drug-coated balloons for interventional urology, including the Optilume products for treating benign prostatic hyperplasia (BPH) and urethral strictures.

HealthtechMedical DevicesPlymouth, US

Junfeng Wang(Director)David Perry(Executive Officer, Director)Tan Ching(Director)Hui Hu(Director, Promoter)Lixiao Wang(Director, Promoter)Doug Kohrs(Director)

Co-investorsHMHM Venture PartnersENEnterprise IrelandGIGilde HealthcareIRIreland Strategic Investment FundLELegend CapitalMVMVM Life Science Partners+1 more

An R&D-driven biopharmaceutical company that uses AI to develop breakthrough medicines and vaccines focused on immune system disorders across five therapeutic areas.

AI & Machine LearningBiotechMedical DevicesCambridge, US

IMIvana Magovcevic-Liebisch(Executive Officer, Director)CVChristopher Verni(Executive Officer)inMary Thistle(Director)Evan Thackaberry(Executive Officer)Suzanne Bruhn(Director)Gerhard Koenig(Director)

Co-investorsATAtlas VentureHAHatteras Venture PartnersPIPivotal Life SciencesVIVida VenturesLOLongwood Fund

Medical Devices

Co-investorsVEVensana Capital

Willow (originally founded as Contento) offers social media management for small and medium-sized B2B professional service providers, combining a scheduling and content platform with AI tools and human social media coaching.

AI & Machine LearningEnterprise SoftwareMarketing TechSaaSGhent, BE

LDLudwig Dumont(Founder)in

Co-investorsPMPMVSMSmartFinIMimec.istartHEHetz VenturesMEMeritech Capital PartnersNENew Enterprise Associates (NEA)