.406 Ventures — 2026 Investments
7 investments dated 2026 · listed companies and verified rows first · show all
Big Health develops digital treatments and care programs for mental health conditions, including cognitive behavioral therapy-based solutions for insomnia and other mental health issues.
Digital HealthHealthtechMental Health
Peter Hames(Co-founder)inColin Espie(Co-founder & Chief Scientist)in
Co-investors515 VenturesAlleyCorpBlue Venture FundsIndex VenturesInnovation Global CapitalKaiser Permanente Ventures+9 more
Elmsford, US
Jonathan Taqqu(Executive Officer, Director)
BoardJohn Lee(Director)
Co-investorsHealthy VenturesAlleyCorpCVS Health VenturesGilde HealthcareSandbox Clinical Ventures
Genesis Computing builds an agentic data engineering system ("Genesis Data Agents") of AI workers that run inside customer-managed environments alongside platforms such as Snowflake, AWS, and Databricks to accelerate the enterprise data lifecycle and preserve institutional knowledge.
AI & Machine LearningData & InfrastructureEnterprise SoftwareWilmington, US
Justin Langseth(Co-founder & CTO)inMatt Glickman(Co-founder & CEO)inAnton Gorshkov(Head of Engineering)inVince Trotta(Head of Sales)Margarita Barrera(Chief Operating Officer)in
BoardBen Holzman(Director)
Co-investorsEval Ventures FundNextGen Venture PartnersKearny Jackson
RELAI builds a continual learning infrastructure system that enables AI agents to improve themselves through experience by converting failures and feedback into continuous optimization across prompts, tools, memory, and models.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareBethesda, US
Soheil Feizi(Founder)inLaurent Py(Director)
BoardKevin Wang(Director)in
Co-investorsNon Sibi VenturesAITFundTEDCO
RoundUp.org lets donors link a credit card to automatically round up everyday purchases to the next dollar and donate the spare change to a nonprofit of their choice.
FintechImpact & Social Good
Jed Carlson(Founder / CEO)in
Co-investorsDuke Capital PartnersSilverton PartnersAlbum VCIQ CapitalKarma VenturesSMBC Asia Rising Fund
Teal provides telehealth healthcare services for people assigned female at birth, offering virtual care without traditional in-office procedures.
Digital HealthFemTechHealthtechSan Francisco, US
Kara Egan(Founder)inAvnesh Thakor(Founder)Joseph DeSimone(Director)Matthew Bettonville(Director)Kathryn Taylor Reddy(Director)Sarah Rose(Executive Officer)
Co-investorsAventurine PartnersBlack Jays VenturesFelicis VenturesForerunner VenturesHalogen Ventures Management Company LlcMetrodora Ventures+8 more
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.








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