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Barbara Weber

Investor

Board director at Tango Therapeutics

Boston, Massachusetts

Writes $100K – $5M checks · typically $1.5M

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Ask Reid Huber to introduce you to Barbara

You →Reid · together at Tango Therapeutics (2019–2023) →Barbara

Ask Jamie Chen to introduce you to Barbara

You →Jamie · together at Tango Therapeutics →Barbara

Ask Sam Okafor to introduce you to Barbara

You →Sam · together at Parabilis Medicines →Barbara

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About

Barbara Weber serves as Chairperson of the Board at Tango Therapeutics, a company she helped establish through Third Rock Ventures in 2015 and led as CEO from September 2017 through January 2026. Under her leadership, Tango grew from six employees to over 150 researchers and drug developers focused on cancer genetics, expanding its pipeline to include vopimetostat, a PRMT5 inhibitor entering pivotal development in pancreatic cancer.

Board director at Tango Therapeutics

Intro paths

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In turn, Barbara can intro founders to Tango Therapeutics's investors below.

Tango Therapeutics's investors · 4

Foresite CapitalWest HollywoodNextech InvestZurich · $648K – $3.2M checks · since 2025NSG VenturesSingaporeThird Rock VenturesBoston · $100K – $5M checks · since 2023

Co-founders at Tango Therapeutics

AHAlan Huang
Alan HuangExecutive Officer

Experience

  1. Tango TherapeuticsChairperson of the Boardcurrent2026 — presentBoston, Massachusetts, United States
  2. Tango TherapeuticsPresident and CEO2017 — 2026Cambridge, MA
  3. ITM Isotope Technologies Munich SEBoard Membercurrent2025 — present
  4. Sesame TherapeuticsBoard Membercurrent2023 — present
  5. Parabilis MedicinesBoard Membercurrent2018 — presentCambridge, Massachusetts
  6. REVOLUTION MedicinesBoard Member2018 — 2025Redwood City, California
  7. Third Rock VenturesVenture Partner2015 — 2019Boston, MA
  8. NovartisSVP, Oncology Translational Medicine2009 — 2015Cambridge, MA
  9. GlaxoSmithKlineVP, Oncology2005 — 2009Greater Philadelphia
  10. University of PennsylvaniaProfessor of Medicine and Genetics1994 — 2005Philadelphia, PA
  11. University of MichiganAssistant Professor of Medicine1988 — 1994Ann Arbor, Michigan
  12. Dana-Farber Cancer InstituteMedical Oncology Fellow1985 — 1988Greater Boston

Skills & more

Clinical Development17Oncology52

From Barbara's professional profile.

Deals · 1

Revolution MedicinesBoard seat

via Third Rock Ventures · filed Jul 2018 · $56.4M raise

Attribution from SEC filings, press coverage, and firm rosters.

Network10

Abbie Celniker
Investor at Third Rock Ventures
Alan Ezekowitz
Investor at Third Rock Ventures
Andrea van Elsas
Investor at Third Rock Ventures
Andrew Warren
Senior Associate at Third Rock Ventures
Beryl Cummings
Senior Associate at Third Rock Ventures
Cary Pfeffer
Investor at Third Rock Ventures
Charles Homcy
Investor at Third Rock Ventures
Christoph Lengauer
CSO at Curie.Bio
Craig Muir
Investor at Third Rock Ventures
David Kaufman
Investor at Third Rock Ventures

Investors connected to Barbara in public investor directories — a warm-intro map.

Frequently asked questions

Who is Barbara Weber?
Barbara Weber serves as Chairperson of the Board at Tango Therapeutics, a company she helped establish through Third Rock Ventures in 2015 and led as CEO from September 2017 through January 2026. Under her leadership, Tango grew from six employees to over 150 researchers and drug developers focused on cancer genetics, expanding its pipeline to include vopimetostat, a PRMT5 inhibitor entering pivotal development in pancreatic cancer.
Where does Barbara Weber work?
Barbara Weber is Board director at Tango Therapeutics.
What check size does Barbara Weber write?
Barbara Weber typically writes checks of $100K – $5M.
What boards does Barbara Weber sit on?
Barbara Weber holds tracked board seats at Revolution Medicines.
Where did Barbara Weber go to school?
Barbara Weber studied at Yale University (Resident in Internal Medicine); University of Washington - School of Medicine (Doctor of Medicine (M.D.), Medicine); University of Washington (Bachelor's Degree, Chemistry).

Founder mafias

Parabilis Medicines mafia2

Also came through, then founded or led a company.

Mathai MammenCEO, President and ChairmanFounded Fogpharma

Same school

Shared employers