Fundraising Fox

Barbara Weber

InvestorFounder

Venture Partner at Third Rock Ventures · Board director at Tango Therapeutics

Boston, Massachusetts

Writes $100K – $5M checks · typically $1.5M

FoundedTango Therapeutics

About

Barbara Weber serves as Chairperson of the Board at Tango Therapeutics, a company she helped establish through Third Rock Ventures in 2015 and led as CEO from September 2017 through January 2026. Under her leadership, Tango grew from six employees to over 150 researchers and drug developers focused on cancer genetics, expanding its pipeline to include vopimetostat, a PRMT5 inhibitor entering pivotal development in pancreatic cancer.

Board director at Tango Therapeutics

Intro paths

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In turn, Barbara can intro founders to Tango Therapeutics's investors below.

Tango Therapeutics's investors · 4

Foresite CapitalLarkspurNextech InvestZurich · $648K – $3.2M checks · since 2025NSG VenturesSingaporeThird Rock VenturesBoston · $100K – $5M checks · since 2023

Co-founders at Tango Therapeutics

AH
Alan HuangExecutive Officer
AC
Adam CrystalExecutive Officer
DB
Daniella BeckmanExecutive Officer
DB
Douglas BarryExecutive Officer
AD
Aaron DavisDirector

Experience

  1. Tango TherapeuticsChairperson of the Boardcurrent2026 — presentBoston, Massachusetts, United States
  2. Tango TherapeuticsPresident and CEO2017 — 2026Cambridge, MA
  3. ITM Isotope Technologies Munich SEBoard Membercurrent2025 — present
  4. Sesame TherapeuticsBoard Membercurrent2023 — present
  5. Parabilis MedicinesBoard Membercurrent2018 — presentCambridge, Massachusetts
  6. REVOLUTION MedicinesBoard Member2018 — 2025Redwood City, California
  7. Third Rock VenturesVenture Partner2015 — 2019Boston, MA
  8. NovartisSVP, Oncology Translational Medicine2009 — 2015Cambridge, MA
  9. GlaxoSmithKlineVP, Oncology2005 — 2009Greater Philadelphia
  10. University of PennsylvaniaProfessor of Medicine and Genetics1994 — 2005Philadelphia, PA
  11. University of MichiganAssistant Professor of Medicine1988 — 1994Ann Arbor, Michigan
  12. Dana-Farber Cancer InstituteMedical Oncology Fellow1985 — 1988Greater Boston

Education

  1. Yale UniversityResident in Internal Medicine1982 — 1985
  2. University of Washington - School of MedicineDoctor of Medicine (M.D.), Medicine1978 — 1982
  3. University of WashingtonBachelor's Degree, Chemistry1974 — 1978

Skills & more

Clinical Development17Oncology52Biotechnology19Drug Development25Clinical Trials16Translational Medicine25Drug Discovery6Life Sciences13Medicine10Genetics18Clinical Research7Pharmaceutical Industry18

From Barbara's professional profile.

Deals · 1

Revolution MedicinesBoard seat

via Third Rock Ventures · filed Jul 2018 · $56.4M raise

Attribution from SEC filings, press coverage, and firm rosters.

Colleagues at Third Rock Ventures

Abbie Celniker
Investor at Third Rock Ventures
Adam Tebbe
Investor at Third Rock Ventures
Alan Ezekowitz
Investor at Third Rock Ventures
Alison Connors
Investor at Third Rock Ventures
Amanda Chan
Investor at Third Rock Ventures
Andrea van Elsas
Investor at Third Rock Ventures
Andrew Warren
Senior Associate at Third Rock Ventures
Angelo Severino
Investor at Third Rock Ventures

Network11

Abbie Celniker
Investor at Third Rock Ventures
Alan Ezekowitz
Investor at Third Rock Ventures
Andrea van Elsas
Investor at Third Rock Ventures
Andrew Warren
Senior Associate at Third Rock Ventures
Beryl Cummings
Senior Associate at Third Rock Ventures
Cary Pfeffer
Investor at Third Rock Ventures
Charles Homcy
Investor at Third Rock Ventures
Christoph Lengauer
CSO at Curie.Bio
Craig Muir
Investor at Third Rock Ventures
David Kaufman
Investor at Third Rock Ventures
George Xu
Senior Associate at Third Rock Ventures

Investors connected to Barbara in public investor directories — a warm-intro map.

Frequently asked questions

Where does Barbara Weber work?
Barbara Weber is Venture Partner at Third Rock Ventures and Founder at Tango Therapeutics.
What check size does Barbara Weber write?
Barbara Weber typically writes checks of $100K – $5M.
What companies did Barbara Weber found?
Barbara Weber founded Tango Therapeutics.

Founder mafias

Yale University mafia182

Also came through, then founded or led a company.

Michael SeibelBAFounded SocialCamJustin KanPhysics and PhilosophyFounded Rye +5Kevin RyanBAFounded Business Insider +2Harry GrunerFounded Hilos +2Emmett ShearBSFounded Softmax +2Jake SchwartzBachelor of Arts (B.A.)Founded Brave Health +1

+ 175 more

University of Washington mafia109

Also came through, then founded or led a company.

Matthew ScholzBSFounded Oisin Biotechnologies +3Emmett ShearFounded Softmax +2Sara VaezyMPHFounded Dexcare +1Alec NielsenBachelor of Science (BS)Founded Asimov +1Andrew PetersonBachelor of Science (BS)Founded Aldebaran Therapeutics +1Gordon HemptonB.S.Founded Team Apart +1

+ 102 more

Third Rock Ventures mafia16

Also came through, then founded or led a company.

Reid HuberPartnerFounded MOMA Therapeutics +2Christoph LengauerPartnerFounded Celsius Therapeutics +2Steve PaulVenture PartnerFounded Voyager Therapeutics, Inc. +1Alexis BorisyPartnerFounded Foundation Medicine +1Philip ReillyVenture PartnerFounded Luna Genetics +1Abbie CelnikerPartnerFounded Eleven Biotherapeutics

+ 9 more

University of Washington - School of Medicine mafia4

Also came through, then founded or led a company.

Uri LopatinInternshipFounded Pardes Biosciences +1Julien PhamMDFounded RubiconMDMitch GoldUrologyFounded Alpine Immune Sciences

Revolution Medicines mafia2

Also came through, then founded or led a company.

Alexis BorisyFounding Investor & Board MemberFounded Foundation Medicine +1

Same school

Also attended Yale University619

Ann Miura-KoCo-founding Partner at FloodgateDavid SzeAdvisory Partner at GreylockMichael SeibelPartner Emeritus at Y CombinatorZheela QaiserInvestor at Index VenturesAnthony PhilippakisInvestor at GV (Google Ventures)Karthik ArdhanareeswaranInvestor at GV (Google Ventures)

+ 613 more

Also attended University of Washington - School of Medicine9

Uri LopatinInvestor at Khosla VenturesDennis SchmulandInvestor at EPIC VENTURESDavid CohnInterim Chief Executive Officer and Chief Medical Officer at Oncology VenturesChing-Ping LinPartner & COO at Orbit StartupsJulien PhamFounder & Managing Partner at 3CC | Third Culture CapitalMitch GoldVenture Partner at Frazier Life Sciences

+ 3 more

Also attended University of Washington261

Andrew ChenGeneral Partner at Andreessen HorowitzVictoria TreygerGeneral Partner at Felicis VenturesAndrewAdvisor at Clear VenturesJoe HorsmanInvestor at Madrona Venture GroupTed KummertVenture partner at Madrona focused on enterprise infrastructure, data, and intelligent applicationsJohn CarpenterInformation Technology Director at Madrona Venture Group

+ 255 more

Shared employers

Also worked at Tango Therapeutics2

Reid HuberPartner at Third Rock VenturesAlexis BorisyOperating Chairman at Curie.Bio

Also worked at Parabilis Medicines5

Milenko CicmilVenture Partner at Cure VenturesKenzie MacIsaacPartner at Cure VenturesKenneth GriséPrincipal at Sixty Degree CapitalPatrick ZhangInvestor at Horizons VenturesSonia ParekhAssociate at Longitude Capital

Also worked at Third Rock Ventures78

Lisa PurcellInvestor at Third Rock VenturesPaul MeloneInvestor at Third Rock VenturesKevin MunnellyInvestor at Third Rock VenturesAmanda ChanInvestor at Third Rock VenturesJigar RaythathaInvestor at Third Rock VenturesOlie LuchitskyInvestor at Third Rock Ventures

+ 72 more

Also worked at Novartis126

Rebecca JamesInvestor at Index VenturesScott BillerInvestor at GV (Google Ventures)Freya Svedberg-KeatingInvestor at MedicxiAndrea AmadorCompliance Manager at Inveready Technology Investment GroupAbbie CelnikerInvestor at Third Rock VenturesJesper GromadaInvestor at Third Rock Ventures

+ 120 more