San Francisco · Pre-Seed–Series A · 1 people tracked
Also known as YOSEMITE MANAGEMENT, LLC
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1,025 people in our graph share verified history with the Yosemite team — schools, employers, funds. One of them is your warm intro.
Investment thesis
Cancer-only, high-conviction fund backing frontier oncology technologies (programmable gene therapies, AI-native drug discovery), concentrating ~20 companies from a $200M+ base and merging VC with research philanthropy.
Source: firm website, verified Sep 15, 2026.
Team · 1 people
from public directories
What they invest in
from 16 of 16 portfolio companiesHealthtech ×11AI & Machine Learning ×6Biotech ×5Deep Tech ×5Digital Health ×4Data & Infrastructure ×2Enterprise Software ×2Fintech ×2
HQs:United States×12Canada×1
Investments · 16 tracked
founders shown can be your intro pathBy year:2026 · 32025 · 62023 · 211 dated
Atropos Health develops a cloud-based platform that generates real-world evidence from electronic health records to inform clinical decision-making and healthcare research.
AI & Machine LearningData & InfrastructureDigital HealthHealthtechStanford, US
Nigam Shah(Co-Founder & Chief Data Scientist)Brigham Hyde(Chief Executive Officer & co-Founder)inSaurabh Gombar(Chief Medical Officer & co-Founder)inNigam Shah, PhD MBBS(Co-Founder of Atropos Health & Chief Data Scientist at Stanford Health Care)NEIL SANGHAVI(Executive Officer)in
BoardMATTHEW BETTONVILLE(Director)
Co-investorsBreyer CapitalCencora VenturesCerity Partners Venturesmark vcMcKesson VenturesPresidio Ventures+2 more
Solve Therapeutics is a clinical-stage oncology biotech developing antibody-drug conjugates (ADCs) and radiopharmaceuticals for solid tumors, built around its CloakLink hydrophilic cleavable linker platform and an integrated diagnostic for patient selection.
BiotechDeep TechHealthtech
David Johnson(Chief Executive Officer)Clayton Knox(President)Katti Jessen(SVP, Translational Sciences)Yakov Kogan(Head of Operations)Brian Lannutti(Research & Development Leadership)Langdon Miller(Clinical Development Leadership)
Co-investorsDecheng CapitalMatrix Capital ManagementB Capital GroupB4 Capital
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Quarry Thera is a biotech developing oral small-molecule medicines based on induced-proximity pharmacology, using molecular glues and heterobifunctional compounds.
BiotechDeep TechNew Haven, US
Craig Crews(Co-Founder & Scientific Advisor)inDan McHugh(Manager)Tim Shannon(CEO and Board Member)inJeanne Magram(Chief Scientific Officer)inKanak Raina(Chief Technology Officer)inSean Cassidy(Chief Financial Officer)in
Co-investorsF-Prime CapitalCanaan PartnersLilly Ventures
Eureka Therapeutics is a clinical-stage biopharmaceutical company developing T-cell-based therapies to treat solid tumors and other cancers.
BiotechHealthtechEmeryville, US
Cheng Liu(Executive Officer, Director)in
BoardSandy Chau(Director)Hsing Kung(Director)Qiushi Fu(Director)Chih-Kai Cheng(Director)inMichael Cannon(Director)
Board seatReed Jobs· per SEC Form D · $20M raise · filed May 2023
Co-investorsAcorn Pacific Ventures
Azalea Therapeutics develops precision genome editing therapies that engineer T cells directly inside the patient's body to create cancer immunotherapies, using proprietary delivery vehicles to target and modify specific genetic loci without ex vivo cell manipulation.
AI & Machine LearningBiotechMedical DevicesSan Francisco, US
Jennifer Doudna(Co-founder, Nobel Laureate in Chemistry and Li Ka Shing Chancellor's Chair in Biomedical and Health Sciences, UC Berkeley)Rodolphe Barrangou(Co-founder, Associate Professor of Medicine, UCSF)Krishnendu Roy(Co-founder, Professor of Bioengineering, Stanford University)Connor Tsuchida(Scientific Cofounder)in
Co-investorsThird Rock VenturesRA CapitalSozo Ventures
Daymark provides 24/7 in-home and virtual cancer care, offering patients an oncology-specialized team available by phone, text, video, or home visits to coordinate testing, manage symptoms and medications, and handle care logistics.
Digital HealthHealthtechMental HealthPhiladelphia, US
Justin Bekelman(Executive Officer, Director)inJonathan Rhodes(Founder)inPaul Dufault(Executive Officer)Roy Beveridge(Director)
BoardKelsey Maguire(Director)Ambar Bhattacharyya(Director)
Co-investorsBlue Venture FundsHealthier CapitalOncology VenturesMaverick Ventures
HealthtechMiami, US
Christopher Lee(Executive Officer)inChristian Seale(Executive Officer)inJustin Dangel(Executive Officer)in
Fourier Optics builds Fourier AR, an angular and wavelength-selective metasurface optical combiner embedded invisibly inside ophthalmic lenses that reflects RGB light from a µLED projector to the eye for all-day augmented-reality glasses.
Deep TechHardwareSemiconductors
Dr. Omri Barlev(Founder & CEO)Shoam Shwartz(Founder & CTO)inAsaf Carmel(Founder & VP R&D)in
BoardJoe O'keeffe(Chairman)
Co-investorsMaverick Ventures IsraelLam Capitalfresh.fundInnospark VenturesLasagnaNextGen Venture Partners+1 more
Fourier Health builds infrastructure to unlock unstructured clinical data from healthcare systems, enabling AI models and clinicians to access actionable intelligence from records currently locked in PDFs and fragmented systems.
AI & Machine LearningData & InfrastructureDigital HealthHealthtech
Christopher Lee(Co-Founder & CEO)in
Co-investorsNextGen Venture PartnersTau VenturesInnospark Ventures
Healthier Capital is a venture capital firm that invests in technology-enabled healthcare companies seeking to reduce costs and improve care delivery.
Digital HealthFintechHealthtech
Amir Dan Rubin(CEO and Founding Managing Partner)in
Co-investorsModi VenturesBlack Opal VenturesDefine VenturesHealthier CapitalMacquarie CapitalMaverick Ventures+2 more
Prompt is an Ambient AI product and research company that develops human-centered AI products designed to sense the physical environment.
AI & Machine LearningConsumerDeep TechSan Francisco, US
Tete Xiao(Founder)in
Co-investorsAbstract VenturesAIX VenturesDCVC (Data Collective)Neotribe VenturesBraidwellCDP Venture Capital+3 more
Proxima develops AI-powered gaming experiences and infrastructure, with a focus on embodied AI agents and applied AI systems for interactive entertainment.
AI & Machine LearningGamingSan Francisco, US
Ran Mo(Founder)in
Co-investorsKonvoy VenturesProgressionAIX VenturesAlexandriaBalderton CapitalBayern Kapital+9 more
Sage Care connects families with local caregiving professionals who provide in-home support for aging parents.
HealthtechMarketplacesToronto, CA
Vanessa Lee(Founder)in
Co-investorsGeneral CatalystY CombinatorSV Angel
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Sage Care provides software for home care agency operators to manage lead capture, client conversion, and automated administrative paperwork.
AI & Machine LearningEnterprise SoftwareHealthtechSaaSSan Francisco, US
Jon Levinson(Founder)inIan Gillis(Founder)in
Co-investorsY CombinatorGeneral CatalystSV Angel
Tune Therapeutics develops a therapeutic platform targeting the epigenome to treat complex diseases and regenerative medicine applications.
BiotechDeep TechHealthtechLongevityMedical DevicesDurham and Seattle, US
Akira Matsuno(Executive Officer)inDerek Jantz(Executive Officer)inCharles Gersbach(Director)inJohn McHutchison(CEO, Chairman of the Board)inDan McHugh(Executive Officer, Director)inBlythe Sather(Executive Officer)in
Co-investorsDuke Capital PartnersHatteras Venture PartnersMission BiocapitalNew Enterprise Associates (NEA)
Turquoise builds a healthcare transaction platform designed to reduce administrative waste in the healthcare system by standardizing pricing, benefits, and claims processing for providers, payers, and patients.
Enterprise SoftwareFintechHealthtechSan Diego, US
Chris Severn(Founder)inAdam Geitgey(Director)in
Co-investorsAndreessen HorowitzBessemer Venture PartnersOak HC/FTAdams Street PartnersTiger Global Management
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Portfolio news
latest coverage across their companies
Azalea Therapeutics · newmarketpitch.com · Jul 13, 2026
Proxima · finance.yahoo.com · Jul 7, 2026
Proxima · finance.yahoo.com · Jul 7, 2026
Healthier Capital · castleplacement.com · Jun 10, 2026
Turquoise Health · fiercehealthcare.com · Mar 19, 2026
Quarry Thera · castleplacement.com · Jan 8, 2026
Sage Care · healthcareittoday.com · Dec 1, 2025
Frequently asked questions
- How many investments has Yosemite made?
- Yosemite has 16 tracked investments, including 9 dated in the last 24 months.
- What stage does Yosemite invest at?
- Yosemite invests at the Pre-Seed, Seed, Series A stages.
- What sectors does Yosemite focus on?
- Yosemite focuses on Biotech, Deep Tech, Healthtech, SaaS.
- Where is Yosemite located?
- Yosemite is headquartered in San Francisco, US.
- Does Yosemite lead rounds?
- Yosemite typically participates in rounds rather than leading them.
Media · Podcasts & interviews
featuring the teamReed Jobs on Founding Yosemite and the New Age of Biology
Sabrina Halper Show · Reed Jobs
Yosemite investor & founder Reed Jobs shares his thoughts on AI in biotech.
BiotechTV · Reed Jobs
Rapid Fire Questions answer by Yosemite investor & founder Reed Jobs
BiotechTV · Reed Jobs
Can We Make Cancer Nonlethal? | Reed Jobs & Matt Bettonville of Yosemite
The Heart of Healthcare | A Digital Health Podcast · Reed Jobs
Images
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