Yosemite
Venture capitalActively deployingSan Francisco · Pre-Seed–Series A
Also known as YOSEMITE MANAGEMENT, LLC
Investment thesis
Cancer-only, high-conviction fund backing frontier oncology technologies (programmable gene therapies, AI-native drug discovery), concentrating ~20 companies from a $200M+ base and merging VC with research philanthropy.
Source: firm website, verified Aug 3, 2026.
What they invest in
from 7 of 7 portfolio companiesHealthtech ×6AI & Machine Learning ×3Biotech ×3Data & Infrastructure ×2Deep Tech ×2Digital Health ×2Enterprise Software ×1Longevity ×1
HQs:United States×4Canada×1
Investments · 7 tracked
founders shown can be your intro path
Atropos Health develops a cloud-based platform that generates real-world evidence from electronic health records to inform clinical decision-making and healthcare research.
AI & Machine LearningData & InfrastructureDigital HealthHealthtechStanford, US
Nigam Shah(Co-Founder & Chief Data Scientist)Brigham Hyde(Co-Founder & Chief Executive Officer)Saurabh Gombar(Co-Founder & Chief Medical Officer)MATTHEW BETTONVILLE(Director)NEIL SANGHAVI(Executive Officer)JAMES BREYER(Director)
Solve Therapeutics is a clinical-stage oncology biotech developing antibody-drug conjugates (ADCs) and radiopharmaceuticals for solid tumors, built around its CloakLink hydrophilic cleavable linker platform and an integrated diagnostic for patient selection.
BiotechDeep TechHealthtech
David Johnson(Chief Executive Officer)Clayton Knox(President)Katti Jessen(SVP, Translational Sciences)Yakov Kogan(Head of Operations)Brian Lannutti(Research & Development Leadership)Langdon Miller(Clinical Development Leadership)
BiotechEmeryville, US
Sandy Chau(Director)Cheng Liu(Executive Officer, Director)Hsing Kung(Director)Qiushi Fu(Director)Michael Cannon(Director)Chih-Kai Cheng(Director)
Board seatReed Jobs· per SEC Form D · $20M raise · filed May 2023
Fourier Health builds infrastructure to unlock unstructured clinical data from healthcare systems, enabling AI models and clinicians to access actionable intelligence from records currently locked in PDFs and fragmented systems.
AI & Machine LearningData & InfrastructureDigital HealthHealthtech
Christopher Lee(Co-Founder & CEO)
Tune Therapeutics develops a therapeutic platform targeting the epigenome to treat complex diseases and regenerative medicine applications.
BiotechDeep TechHealthtechLongevityMedical DevicesDurham and Seattle, US
Akira Matsuno(Executive Officer)Derek Jantz(Executive Officer)Charles Gersbach(Director)John McHutchison(CEO, Chairman of the Board)Dan McHugh(Executive Officer, Director)Blythe Sather(Executive Officer)
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does Yosemite invest at?
- Yosemite invests at the Pre-Seed, Seed, Series A stages.
- What sectors does Yosemite focus on?
- Yosemite focuses on Biotech, Deep Tech, Healthtech, SaaS.
- Where is Yosemite located?
- Yosemite is headquartered in San Francisco, US.
- Does Yosemite lead rounds?
- Yosemite typically participates in rounds rather than leading them.
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