Plains Ventures
Venture capitalOklahoma City · Seed–Series A · 3 people tracked
Also known as I2E MANAGEMENT COMPANY, INC.
Investment thesis
Plains Ventures focuses on Seed and Series A investments in companies located between the coasts, aiming to support entrepreneurs building outside traditional coastal tech hubs. Drawing on two decades of industry experience, the firm positions itself as a partner and guide throughout the company lifecycle, from pitch to exit. Beyond providing deployable capital, it leverages an extensive network of investors and subject matter experts to help founders set strategy, access additional funding, and build a foundation for growth across sectors such as software, life sciences, advanced materials, and manufacturing.
Source: firm website, verified Aug 25, 2026.
Team · 3 people
from public directories
What they invest in
from 35 of 39 portfolio companiesMedical Devices ×13Healthtech ×12Advanced Manufacturing ×7Biotech ×6Enterprise Software ×6AI & Machine Learning ×5Digital Health ×5SaaS ×5
HQs:United States×24
Who they back
founder profiles across 21 portfolio companiesFounding team size:solo founder×142 founders×64+ founders×1
Investments · 39 tracked
founders shown can be your intro pathBy year:2025 · 12023 · 12021 · 24 dated
Access Optics is an ISO 13485 certified contract design and manufacturing company specializing in medical device innovation and high-temperature probe production.
Advanced ManufacturingHardwareMedical DevicesBroken Arrow, US
Matthew Gregoire(Executive Officer, Director)
BoardWilliam Paiva(Director)J.P. Lynch(Director)Sean Templemore-Finlayson(Director)
Co-investorsAtento CapitalCortado VenturesOklahoma Life Science
Alkami is a digital banking software platform for financial institutions including community and regional banks and credit unions.
Data & InfrastructureEnterprise SoftwareFintechMarketing TechSaaS
Mike Shootman(President and Chief Executive Officer)
Co-investorsMissionOGS3 Ventures
Game-based learning platform for K-6 students delivering gamified e-learning with analytics.
Co-investorsKCRise Fund
Boddle develops interactive learning software for students that adapts to individual learners and tracks their academic performance.
EdTechTulsa, US
Edna Martinson(Executive Officer)Clarence Tan(Executive Officer, Director)
Co-investorsAtento CapitalCortado VenturesLightship CapitalKCRise FundScout Fund
BPEndo develops a medical device designed to prevent air and fluid incontinence during colonoscopy procedures, improving exam quality and patient safety for gastroenterologists and healthcare facilities.
HealthtechMedical DevicesNorman, US
Robert Holbrook(Founder & CEO)
Co-investorsHurricane Ventures
Cadenza Bio develops small-molecule drugs for oral administration to treat demyelinating and inflammatory diseases.
BiotechFemTechMedical DevicesYukon, US
Carol Curtis, PhD(Chief Executive Officer, Founder)Elaine Hamm, PhD(Chief Operating Officer, Founder)John Katzenellenbogen, PhD(Scientific Founder)Seema Tiwari-Woodruff, PhD(Scientific Founder)Elaine Hamm(Executive Officer, Director)Carol Curtis(Executive Officer, Director)
Co-investorsCortado VenturesIllinois VenturesSmartHealth Catalyzer
Compound Foundry builds and scales direct-to-consumer home brands through in-house, on-shore manufacturing.
Advanced ManufacturingConsumerDirect to ConsumerMid-America, US
John James(Founder)in
Co-investorsAtento CapitalStout Street Capital
Digital Six Laboratories develops and manufactures SCADA and automation solutions for water and wastewater treatment facilities, offering on-site automation and remote monitoring with analytics to optimize operational efficiency.
Advanced ManufacturingEnterprise SoftwareIoTMidwest/Heartland USA, US
BiotechGermantown, US
John Mumm(Executive Officer, Director)Vera Mumm(Executive Officer)Pavel Khrimian(Executive Officer, Director)Lucio Iannone(Director)Sally (Yuanheng) Wang(Director)
Co-investorsLumira Ventures
Firehawk Aerospace manufactures solid rocket motors, energetic materials, and propellant using additive (3D printing) manufacturing to produce propellant grains and hybrid rocket engine components.
Defense TechHardwareSpace TechWilmington, US
Will Edwards(Cofounder)Andrew Wills Edwards(Executive Officer)
Co-investorsBackswing VenturesCathexis VenturesDecisive PointDraper AssociatesRed Beard VenturesVictorum+5 more
IV Ensure develops remote therapeutic monitoring technology for home infusion patients that tracks medication adherence and connects patients with care managers to support consistent treatment.
Digital HealthEnterprise SoftwareHealthtechMedical Devices
Mitchell Berenson(Founder)Debbie Meyer
A food company offering clean, simple, and healthy real food ingredients designed to be easy, enjoyable, and energizing.
KiZE makes clean protein energy bars with simple ingredients, sold through consumer retail channels.
ConsumerFoodTechImpact & Social GoodOklahoma City, US
Jeff Ragan(Founder)in
Linear Health Sciences develops the Orchid Safety Release Valve, a tension-activated device for medical tubing that reduces IV catheter dislodgement and associated patient safety risks in hospitals.
HealthtechMedical DevicesOklahoma, US
Deon Miller(President & Chief Executive Officer)Renae Franz(Chief Operating Officer & Chief Commercial Officer)Casey Harness(Chief Administration Officer & Director of Operations)
Medefy is a mobile-first healthcare navigation platform that helps employers, brokers, TPAs, and public organizations guide members to appropriate care while reducing costs and improving health outcomes.
Enterprise SoftwareHealthtechSaaSTulsa, US
NATHAN GILCHRIST(Executive Officer, Director)inJames Barsness(Executive Officer)MONA JENKINS(Executive Officer)MATT SCOVIL(Executive Officer, Director)in
BoardHeath Butler(Director)in
Co-investorsAtento CapitalCadron Capital PartnersCortado VenturesMercury Fund
Moleculera Biosciences is a precision medicine company that develops blood-based immune-mediated autoantibody testing panels and AI-driven diagnostic tools to identify immune dysfunction underlying chronic neuropsychiatric and cardiovascular disorders, as well as Alzheimer's disease.
AI & Machine LearningBiotechDigital HealthMedical Devices
Monscierge operates a SaaS platform that enables hospitality and healthcare organizations to deliver personalized content and communications across digital touchpoints.
HealthtechSaaSTravel & HospitalityOklahoma City, US
Marcus Robinson(Executive Officer, Director)Mark Costello(Director)
MS Pen Technologies develops molecular data analysis tools for use by researchers, surgeons, and clinicians at the point of care to improve patient outcomes.
Deep TechHealthtechMedical Devices
Livia Eberlin(Co-founder, CSO, Board Director)James Suliburk(Co-founder, CMO, Board Director)Justin Wiseman(CEO & Board Director)
Ordinal provides an AI assistant for 3-1-1 teams that gives municipal staff instant access to city-approved information to resolve resident inquiries faster and more accurately.
AI & Machine LearningEnterprise SoftwareGovTechBentonville, US
Jacob Herrington(Founder)
Co-investorsVenture Center Arkansas
Custom Health operates a connected infrastructure combining pharmacy services, in-home monitoring technology, and pharmacist-led clinical care to support medication management at home.
Digital HealthHealthtechMedical Devices
Co-investorsAtento CapitalCortado VenturesPreface Ventures
PhotoniCare develops OtoSight, an FDA-cleared optical coherence tomography device for non-invasive assessment and monitoring of middle ear infections in healthcare facilities.
Deep TechDigital HealthHealthtechMedical DevicesDurham, US
Ryan Shelton(CEO)Stephen Boppart(CMO)Cary Vance(Executive Officer, Director)
BoardPatrick Zeller(Director)Dale Grogan(Director)inDr. Zishan Haroon(Director)
Co-investorsFirst Leaf CapitalHealthtech CapitalIllinois VenturesMichigan Capital NetworkMichigan RiseOSF Ventures+1 more
Progentec develops diagnostic and digital health solutions for autoimmune disease detection and treatment, including biomarker tests and remote monitoring technologies for clinicians and patients.
BiotechDigital HealthMedical DevicesOklahoma City, US
Mohan Purushothaman(CEO)Mohan Purushothaman, Ph.D.(President, Chairman, & CEO)Robert Saunders(Director)Sanjiv Sharma(Executive Officer, Director)
Rest provides IoT-based smoke detection sensors and monitoring services for hotels to enforce no-smoking policies and maintain air quality.
HealthtechIoT
Co-investorsGreat North VenturesBigfoot Capital
Oklahoma City, US
Laura Fleet(Executive Officer, Director)David Fleet(Executive Officer, Director)
Co-investorsFortySix Venture CapitalIrishAngels
Simergent develops medical device systems for regulated healthcare markets, with expertise in peritoneal dialysis and infusion pump technologies.
BiotechHealthtechMedical DevicesChicago, US
Steve J. Lindo(Co-founder & CEO)Rick Pendergraft(Co-founder & Chief Technology Officer)Dr. James Sloand(Chief Medical Officer)Michael Rohleder(Manager)
Co-investorsAngel Physicians FundPathway Bioventures
Spiers New Technologies provides end-to-end EV battery management services including diagnostics, repair, refurbishment, recycling, storage, and logistics.
Advanced ManufacturingCleantechEnergyLogistics & Supply ChainOklahoma City, US
Dirk Spiers(Executive Officer, Director)
BoardJames Joseph Greenberger(Executive Officer, Director)
Tailwind is a marketing platform that helps small businesses plan campaigns, create content, and distribute it across multiple social media channels.
Creator EconomyMarketing TechSaaS
Daniel Maloney(Founder)in
Co-investorsPilot Growth EquityRecurring Capital Partners
Ten-Nine Technologies develops TENIX®, a nano-additive powder that improves lithium-ion battery performance and longevity by stabilizing cathode degradation.
CleantechEnergyNew MaterialsTulsa, US
Paige Johnson
Expert TA develops an online homework and tutoring platform for physics and STEM education, using AI-driven grading and tutoring interactions to help students learn.
AI & Machine LearningEdTechNorth Carolina, US
Jeremy Morton(CEO and Founder)in
Vault Ice manufactures and distributes large-format, ready-to-use premium craft cocktail ice for the food and beverage industry.
Advanced ManufacturingFoodTech
VesprSolar manufactures PV panel fasteners and rail systems designed for large-format solar modules to handle extreme weather and reduce installation time.
CleantechEnergyHardwareSomerville, US
Robert Sewell(Executive Officer, Director, Promoter)inJames Sewell(Director)
Co-investorsAtlanta Technology AngelsLaunchpad Venture GroupSWAN Impact Network
Wheeler Bio operates as a contract development and manufacturing organization (CDMO) for biomanufacturing, providing development and manufacturing expertise for biologics therapeutics.
Advanced ManufacturingAI & Machine LearningBiotechHealthtechMedical DevicesOklahoma, US
Jesse McCool(Executive Officer)Patrick Lucy(Chief Executive Officer)inKeith McCormick(Executive Officer)Errik Anderson(Director)Stephen Hamilton(Executive Officer)Yuk Chun Chiu(Executive Officer)
Co-investorsCarnrite VenturesFloating PointGermin8 Ventures
WS Robots manufactures autonomous mobile robots designed for aerospace manufacturing and maintenance operations, combining artificial intelligence and customizable end-effectors to automate precision tasks in production facilities.
Advanced ManufacturingAI & Machine LearningRobotics
Co-investorsCortado VenturesAero X VenturesCubit Capital
Portfolio news
latest coverage across their companiesAlkami · stocktitan.net · Jul 14, 2026
Firehawk · finsmes.com · Nov 17, 2025
Frequently asked questions
- How many investments has Plains Ventures made?
- Plains Ventures has 39 tracked investments, including 1 dated in the last 24 months.
- What stage does Plains Ventures invest at?
- Plains Ventures invests at the Seed, Series A stages.
- What is Plains Ventures's typical check size?
- Plains Ventures typically writes checks of $250K – $1M.
- What sectors does Plains Ventures focus on?
- Plains Ventures focuses on Advanced Manufacturing, Biotech, Deep Tech, Medical Devices, New Materials, SaaS, Sector Agnostic.
- Where is Plains Ventures located?
- Plains Ventures is headquartered in Oklahoma City, US.
- Who does Plains Ventures co-invest with?
- Plains Ventures most often shares deals with Cortado Ventures, Atento Capital, Illinois Ventures, among 39 tracked co-investors.
Media · Podcasts & interviews
featuring the teamRevolutionary Ideas Between The Coast with Justin Wilson, Plains Ventures - Strategic Growth Ep195
The Golding Group Business Growth Consulting · Justin Wilson
Images
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