Wireframe Ventures — Full Portfolio

Palantir builds data integration and analysis platforms — Gotham for defence and government, Foundry for commercial operations — and deploys forward engineers inside customer organisations.

Palo Alto, US

Alexander Karp(Executive Officer, Director)PTPeter Thiel(Director)inSCStephen Cohen(Director)Nathan Gettings(Executive Officer, Director)JLJoe Lonsdale(Co-founder)in

BoardCAColin Anderson(Executive Officer)in

Co-investors13137 Ventures8V8VCA*A*AKAkkadian VenturesALAllied Venture PartnersARArtis Ventures+35 more

Bedrock Energy develops drilling technology and data algorithms for designing and installing geothermal borehole fields used for building heating and cooling.

CleantechClimate TechEnergyLos Angeles, US

SLSilviu Livescu(Executive Officer)inJLJoselyn Lai(Executive Officer, Director)inJoel Wishkovsky(Executive Officer, Director)

Board seatPaul Straub· per SEC Form D

Co-investorsCACantos VenturesENEnergy Impact PartnersFIFirst Star VenturesTITitanium VenturesTOToba CapitalCLClimate Capital+4 more

San Francisco, US

Muffadal Ghadiali(Executive Officer, Director, Promoter)Naeem Zafar(Director)

BoardJLJulie Lein(Director)in

Board seatPSPaul Straub· per SEC Form D

Co-investorsACAcario InnovationBLBlackhorn VenturesURUrban InnovationLELemnos VC

Salient produces AI-powered subseasonal-to-seasonal weather and climate forecasts spanning one day to one year, using deep neural networks trained on ocean, land-surface, and climate data.

AI & Machine LearningClimate TechDeep TechFalmouth, US

Matthew Stein(Executive Officer, Director)RSRaymond Schmitt(Executive Officer, Director)inRSRay Schmitt(Co-founder)inESEric Schmitt(Co-founder)inSSStephen Schmitt(Co-founder)in

Board seatPaul Straub· per SEC Form D

Co-investorsBLBlindspot Ventures Management CoENEndeavor8FIFirst Star VenturesMUMunich Re Ventures

Applied Carbon develops technologies to regenerate soil and sequester atmospheric carbon for climate change mitigation and soil health improvement.

AgTechCleantechClimate Tech

JAJason Aramburu(CEO + Co-Founder)inMMMorgan M. Williams(COO + Co-Founder)in

Co-investorsAUAutodesk FoundationCOCongruent VenturesS2S2G InvestmentsTOTO VCZAZag CapitalOVOverture Climate+1 more

Argon provides software supply chain security that connects to existing CI/CD pipelines via an agentless implementation to map development environments, assets, code, and user activities, and uses code-tampering detection to prevent supply chain attacks.

Cloud ComputingCybersecurityDeveloper ToolsTel Aviv, IL

EEEilon Elhadad(CEO & Co-Founder)in

Co-investorsHYHyperwise VenturesCRCrosslink CapitalY Y Combinator

Monte Nido provides evidence-based residential and virtual treatment programs for eating disorders across all diagnoses, with specialized care for adolescents and adults.

Digital HealthHealthtechMental HealthWellness & Fitness

Co-investorsACAcumen AmericaBLBluestein VenturesFTFTW VenturesVEVery Serious VenturesBBBBG VenturesINInflect Health

GeneSight offers pharmacogenomic testing that analyzes how a patient's genes affect their response to psychiatric medications, helping clinicians optimize treatment selection and dosing for conditions like depression, anxiety, and ADHD.

BiotechDigital HealthHealthtechMedical DevicesMental Health

Co-investorsALAllos VenturesCICincyTechCRCross Creek Advisors

Astronomer provides Astro, a platform for running Apache Airflow, the open-source data orchestration tool used by enterprises to manage AI, ML, and analytics pipelines at scale.

AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsCincinnati, US

RWRy Walker(Founder)inViraj Parekh(Founder)inJOJoe Otto(Founder)inGreg NeiheiselTBTim Brunk(Executive Officer, Director)inRyan Walker(Executive Officer, Director)

Co-investors50500 GlobalANAngelPadBABain Capital VenturesBOBosch VenturesCICincyTechCOConnetic Ventures+11 more

Caladan provides financial services or investment management, with a team drawn from finance, real estate, and creative backgrounds.

Crypto & Web3FintechSector AgnosticSingapore, SG

John GuNYNigel YoungEWEva WenginRCRemi ColinmaireinSZStephany Zooin

Co-investorsALAlphaLab CapitalCOCollaborative FundLELerer HippeauTWTwelve Below

Caladan Bio develops high-throughput benchtop bioreactor hardware and software for laboratory bioprocessing, enabling faster experimentation and lower costs for biotech R&D teams.

AI & Machine LearningBiotechHardwareNew York, US

Michael Kobida(Founder)inRJRob Jauquet(Founder)in

Co-investorsCOCollaborative FundLELerer HippeauRIRitual CapitalTWTwelve BelowFAFactorial Capital

CanopyClimate helps companies, non-profits, and organizations measure and reduce their collective employee emissions through team-based climate action tracking and reporting.

CleantechClimate TechEnergyEnterprise SoftwareFintechSaaS

Co-investorsBUBuoyant Ventures Management, Llc

Cocoon develops low-carbon construction materials, including LoopCem, a supplementary cementitious material (SCM) made by valorizing electric arc furnace (EAF) steel slag to reduce concrete emissions.

Circular EconomyCleantechClimate TechNew MaterialsLondon, GB

EBEliot Brooks(CEO)inWKWilliam Knapp(Founder)inFSFreddie Scott(CTO)in

Co-investorsBRBrick Mortar VenturesGIGigascale CapitalSOSOSVTHThe Venture CollectiveFIFirst Round CapitalINIndex Ventures+3 more

DNAnexus operates a cloud platform for managing, analyzing, and collaborating on multiomic and clinical data, supporting bioinformatics workflows, AI/ML analytics, and cohort analysis.

AI & Machine LearningBiotechCloud ComputingData & InfrastructureMountain View, US

ASAndreas Sundquist(Executive Officer, Director)inRDRichard Daly(Executive Officer, Director)inGeorge Asimenos, PhD(Chief Product Officer)in

BoardMGMichael Goldberg(Director)Geoff Duyk(Director)KYKrishna Yeshwant(Director)in

Co-investorsCLClaremont Creek VenturesFOForesite CapitalGVGV (Google Ventures)K9K9 VenturesUNUncork Capital

Endpoint Health develops precision medicine tools and targeted therapies for patients with critical illnesses like sepsis and ARDS, leveraging big data and AI to personalize treatment.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesSan Jose, US

Jason Springs(Co-Founder, CEO)Diego Rey(Co-Founder, CSO)Leonardo Teixeira(Co-Founder, COO)Jeff Osborn(Co-Founder, CTO)

Co-investorsHUHumboldt

The U.S.

CleantechEnergyGovTech

Co-investorsFRFranklin TempletonPRPrelude VenturesSESequoia CapitalT.T. Rowe Price

Enveda operates a drug-discovery platform that analyzes natural samples—primarily plant-derived molecules—using mass spectrometry, AI foundation models, and automated high-throughput labs to identify their chemical structures and therapeutic properties.

AI & Machine LearningBiotechDeep Tech

VCViswa Colluru, PhD(Founder)in

Co-investorsJAJAZZ Venture PartnersLULux CapitalVIVillage GlobalFPFPVTRTrue Ventures

Full Harvest builds an agentic intelligence platform that orchestrates transactions and operations across the North American fresh produce supply chain, helping buyers and growers navigate climate volatility, labor shortages, and regulatory complexity.

AgTechAI & Machine LearningLogistics & Supply Chain

Co-investorsASAstiaDODoon CapitalMAmark vcPOPortfoliaRARadicle GrowthRERethink Impact+3 more

Geneticure offers a patented genetic test that uses a cheek-swab DNA sample, analyzing 17 genotypes across 11 genes to recommend personalized hypertension (blood pressure) treatment plans.

BiotechDigital HealthHealthtechMedical DevicesEden Prairie, US

SSScott Snyder(Chief Executive Officer)inESEric Snyder(Chief Operating Officer)inRSRyan Sprissler(Chief Scientific Officer)inTom Olson(Chief Clinical Officer)

Great Sky develops physics-based computational intelligence and AI systems built from foundational research.

AI & Machine LearningDeep TechHardwareBoulder, US

JSJeffrey Shainline(Executive Officer, Director)inMWMark Wade(Director)in

BoardTBTom Biegala(Director)in

Co-investorsBIBison VenturesMAMatchstick VenturesMYMythos Ventures Management, LlcRARange VCSEService Provider CapitalARArcTern Ventures

Gridware provides real-time monitoring and visibility of electrical grid conditions through sensors deployed on power lines, enabling utilities and line workers to detect and respond to problems faster.

Advanced ManufacturingClimate TechEnergyEnterprise SoftwareHardwareIoTSan Francisco, US

TBTim Barat(Founder)inOBOmar B(Founder)inHCHall Chen(Co-Founder & CTO)in

Co-investorsAIAiSprouts VCANAnorak VenturesCOConvective CapitalFIFifty YearsHAHAWKTAILLOLOWERCARBON+7 more

LevelTen Energy operates a platform that connects renewable energy developers with customers and market participants, facilitating project visibility and deal-making in the renewable energy sector.

B2B MarketplacesCleantechClimate TechEnergySaaSSeattle, US

BSBryce Smith(Executive Officer, Director)inSBSmith Bryce(Executive Officer, Director)inWilliam Thomas(Executive Officer)

BoardDCDavid Cohen(Director)inKWKarly Wentz(Director)inGreg Lyons(Director)

Co-investorsASAster CapitalB B Capital GroupB4B4 CapitalCOConstellation Technology VenturesPRPrelude VenturesTETechstars+1 more

Mammoth Bio develops technology to read and write the code of life, operating in the biotechnology sector.

BiotechDeep TechMedical DevicesBrisbane, US

JDJennifer Doudna(Founder)inTMTrevor Martin(Co-founder, Chief Executive Officer)inJCJanice Chen(Co-founder, Chief Scientific Officer & President, Research)inLHLucas Harrington(Co-founder)inATAshley Tehranchi(Executive Officer, Director)in

BoardUrshit Parikh(Director)

Co-investors8V8VCBEBerkeley FrontierCACALIFORNIA INNOVATIONDEDecheng CapitalFOForesite CapitalMAMayfield Fund+9 more

MycoWorks produces Reishi, a premium biomaterial made from Fine Mycelium, used as a sustainable leather alternative in furniture, design, and automotive products.

BiotechCircular EconomyNew MaterialsEmeryville, US

Philip Ross(Director)inMichael Lindheim(Executive Officer)MSMatthew Scullin(Executive Officer, Director)in

BoardKiersten Stead(Director)inThomas Grotkjaer(Director)

Co-investorsDCDCVC (Data Collective)HEHemisphere Ventures LLC8V8VCAGAgFunderDCDCVC BioHUHumboldt+4 more

Near Space Labs provides high-resolution 7cm geospatial imagery captured from stratospheric altitudes, serving government, utilities, insurance, and environmental monitoring applications with frequent data refresh cycles and wide-scale coverage.

Climate TechData & InfrastructureSpace TechBrooklyn, US

RMRema Matevosyan(Founder & CEO)inHripsime Matevosyan(Executive Officer, Director)Albert Caubet Domingo(Director)

Co-investorsATAt One VenturesBLBlackhorn VenturesBOBold Capital PartnersCRCrosslink CapitalDRDraper AssociatesGRGreen Egg Ventures+7 more

OpenInvest builds investment portfolio management software that customizes stock and bond holdings based on individual investor values and ethical preferences, while maintaining performance relative to standard market benchmarks.

FintechSan Francisco, US

CMConor Murray(Founder/CEO)inPWPhillip Wei(Founder/CTO)in

Co-investorsANAndreessen HorowitzY Y CombinatorABAbstract Ventures

Passkey operates Locksmith, a computational platform that uses human genetics, biology, and pharmacology to identify synergistic drug combinations from approved and late-stage drugs, allowing existing assets to be repurposed for new indications.

AI & Machine LearningBiotechDeep Tech

Co-investorsBIBison VenturesBRBreakout Ventures

Pasture Bio develops a vaccine designed to disrupt methane-producing microbes in cattle's rumen, reducing enteric fermentation emissions while improving productivity and animal health.

AgTechBiotechClimate TechSan Francisco, US

Co-investorsCACavallo VenturesGIGigascale Capital

Phytoform Labs develops GM-free genome editing tools and trait engineering technologies for crop improvement, with a focus on potato and tomato varieties.

AgTechAI & Machine LearningBiotechHarpenden, GB

WPWilliam Pelton(Executive Officer, Director)inNKNicholas Kral(Director)Dhiraj Singh(Director)

Co-investorsBABackedENEniac VenturesFIFine Structures VenturesFTFTW VenturesMAManta Ray VenturesRERefactor Capital+1 more

Recurrent builds software and data analytics tools to help consumers and dealerships transition to electric vehicles and optimize EV adoption.

Climate TechData & InfrastructureMobility & TransportationRetail TechSaaS

SCScott Case(Founder)in

Co-investorsASAscend Venture CapitalAUAutomotive Ventures MobilityENEnerTech CapitalPRPrelude VenturesAUAutomotive VenturesE8E8 Angels+3 more

Regeneron is a biotechnology company that develops medicines ranging from biologics to genetic medicines to treat serious diseases across areas such as metabolic disease, ophthalmology, and rare disease.

BiotechHealthtechTarrytown, US

Co-investorsRIRidgeback CapitalSASanderling VenturesVEvenBio Partners

Reverie Labs develops cancer treatments designed to cross the blood-brain barrier and treat tumors in the central nervous system.

AI & Machine LearningBiotechHealthtechBoston, US

AGAnkit Gupta(Founder/CTO)inCDConnor Duffy(Founder)inJKJonah Kallenbach(Founder)in

Co-investorsDODorm RoomLILifeforce CapitalRURuvento Ventures Pte Ltd.Y Y CombinatorFIFirst Round CapitalNENeo

New York, US

Kurt Breitenkamp(Executive Officer, Director)Orion Cohen(Executive Officer, Director)Ian Samuels(Director)Sarah Istel(Director)

Co-investorsSOSocial Starts

Video editing and collaboration platform.

Co-investorsRERembrandt Venture PartnersSCScribble VenturesTRTransmedia CapitalGRGreylock Partners

Siren Optics builds material analysis systems that use cold atmospheric plasma and AI to perform real-time, non-destructive inspection of materials such as wafers, films, coatings, and battery components.

Advanced ManufacturingAI & Machine LearningDeep TechOakland, US

JOJared O'Leary(Executive Officer, Director, Promoter)in

BoardMatthew Blaine(Director)

Co-investorsINInMotion VenturesUNUNION Labs VenturesVOVoyager Partners

Slack is an AI-powered communication platform that consolidates conversations, applications, and customer interactions in a single workspace for businesses.

Enterprise SoftwareFuture of WorkSaaSSan Francisco, US

CHCal Henderson(Co-founder & CTO)inSBStewart Butterfield(Co-founder & CEO)in

Co-investors191991 VenturesACAccelACACME CapitalACAcrew CapitalAGAglae VenturesANAndreessen Horowitz+36 more

Sora Schools provides an engaging, personalized learning experience built by educators, designers, and engineers.

EdTech

Co-investorsCOContraryHOHoneystone VenturesUNUnion Square Ventures (USV)INInspired CapitalNENew Enterprise Associates (NEA)PEPeak State Ventures+3 more

Sora Fuel produces sustainable aviation fuel (SAF) and diesel using a proprietary closed-loop direct air capture and conversion process that draws carbon from air rather than biomass or industrial feedstocks.

CleantechClimate TechEnergyCambridge, US

Curtis BerlinguetteinGareth Ross(Executive Officer, Director)inCurtis Belinguete(Director)

BoardPatrick Sarver(Director)inMTMarc Tarpenning(Director)inMKMichael Kearney(Director)in

Co-investorsINInnovation UBCINInspired CapitalLELeitmotifSPSpero VenturesTHThe Engine Ventures

SPAN develops smart electrical panels that provide real-time home energy monitoring and control, enabling homeowners to track and optimize energy consumption at the room and appliance level to reduce energy bills.

CleantechHardwareIoTSan Francisco, US

ARArch Rao(Founder & CEO)in

Co-investorsANAngeleno GroupARArcTern VenturesCOCollaborative FundCOCongruent VenturesDEDesigner FundEAEarth Foundry+15 more

SuperCircle is a technology and reverse logistics platform that helps retail brands launch trade-in programs and manage excess inventory to reduce textile waste.

Circular EconomyLogistics & Supply ChainSaaS

CMChloe Marie Songer(Founder)inStuart Ahlum(Founder)in

Co-investorsFAFab Co-Creation Studio VenturesFOFoundryRARadicle ImpactRARareBreed VenturesSTStarting LineULUlu Ventures+3 more

Synop provides an all-in-one software platform for managing commercial electric vehicle fleets, charging stations, and distributed energy resources such as battery storage.

EnergyMobility & TransportationSaaSCarmel, US

Andrew Blejde(Executive Officer, Director)inGDGagan DhilloninGagandeep Dhillon(Executive Officer, Director)

Co-investorsBEBetter Ventures Central LlcCOCongruent VenturesOBObvious VenturesBEBetter VenturesCOCongruent

Tembo builds a platform that serves as an operating layer for software engineering teams, providing secure execution, shared context, and workflow coordination for AI coding agents.

AI & Machine LearningCloud ComputingDeveloper ToolsEnterprise Software

RWRy Walker(Founder)in

Co-investorsGRGreatPoint VenturesCICincyTechCICintrifuse CapitalGRGrand VenturesASAscensionAVAviva Investors+4 more

Terraline offers a software-defined vehicle (SDV) platform that unifies vehicle control and telemetry, providing over-the-air updates, digital dashboards, and autonomy-ready APIs for intelligent machines and vehicles.

HardwareIoTMobility & TransportationMountain View, US

Co-investorsINiNetworksMAManiv MobilityTRTrucks VC

Think Bioscience develops new medicines for diseases with limited treatment options through synthetic biology and computational chemistry.

BiotechDeep Tech

Co-investorsAVAV8 VenturesBUBuff Gold VenturesCUCU Healthcare Innovation FundAXAxial VC

Trove operates a platform for brand resale and recommerce, enabling iconic brands to sell returned and excess inventory through secondary markets.

AI & Machine LearningB2B MarketplacesCircular EconomyRetail TechBrisbane, US

ANDREW RUBEN(Director, Promoter)John Connolly(Founder)inGTGAYLE TAIT(Executive Officer, Director)in

BoardGKGABRIEL KRA(Director)inBPBROOK PORTER(Director)inSHELLEY BRANSTEN(Director)

Co-investorsARArcTern VenturesCLClaremont Creek VenturesCOCommerce VenturesDBDBL PartnersG2G2 Venture PartnersGLGlobal Brain+5 more

Tyba builds technology and modeling tools to help companies develop and operate energy storage projects more profitably.

AI & Machine LearningCleantechClimate TechEnergySan Francisco, US

Michael Baker(Co-founder & CEO)inTom Thunell(Co-Founder & COO)inTyler(Co-Founder & CTO)

Co-investorsENEnergize CapitalLOLorimer VenturesVIVirta Ventures

Xcimer Energy develops laser-driven inertial fusion technology, aiming to turn decades of fusion research into commercial fusion power plants that provide large-scale electricity while supporting air defense and national security applications.

CleantechDeep TechEnergyDenver, US

CGConner Galloway(Executive Officer, Director)inAVAlexander Valys(President, Founder)inBGBrent Gill(Chief Operating Officer)inGSGary Sobolevskiy(General Counsel)in

Co-investorsBRBreakthrough Energy VenturesGIGigascale CapitalLELeitmotifLOLOWERCARBONLOLowercarbon CapitalPRPrelude Ventures+1 more

Xtelligent develops next-generation traffic signal control technology using control algorithms, real-time data streams, and machine learning to enable adaptive, multimodal, and cooperative management of signalized intersections for cities.

AI & Machine LearningGovTechMobility & Transportation

Co-investorsCOCongruent VenturesTHThird Sphere

Zivian Health builds compliance infrastructure and workforce management software for healthcare providers, nurses practitioners, and physician assistants operating across multiple states or remotely.

Digital HealthHealthtechSaaS

RFRafid Fadul(Co-founder, Chief Medical Officer)inGMGriffin Mulcahey(Co-founder, CEO)inJMJaclyn Miller(Chief Product Officer)inVVanessa(Engineering Leader)

Co-investorsRARally Ventures Management, LlcCRCrosslink CapitalNENextView VenturesBLBlumberg CapitalGRGradient Ventures