Abingworth — Full Portfolio

OnKure Therapeutics is a clinical-stage biopharmaceutical company developing PI3Kα pan-mutant selective inhibitor medicines for the treatment of breast cancer and vascular anomalies.

BiotechDigital HealthHealthtechMedical DevicesBoulder, US

JLJason Leverone(Executive Officer)inSASamuel Agresta(Executive Officer)inDHDylan Hartley(Executive Officer)inWendy Johnson(Executive Officer)Nicholas A. Saccomano(President and Chief Executive Officer and Director)

BoardIMIsaac Manke(Director)in

Board seatBMBali Muralidhar· per SEC Form D

Co-investorsACAccess BiotechnologyBOBoulder VenturesRIRiverVest Venture PartnersACACORN BIOVENTURESNENew Enterprise Associates (NEA)NONovo Holdings

Spruce Biosciences develops and commercializes therapies for serious neurological and endocrine disorders with unmet medical need, with a lead investigational enzyme replacement therapy (TA-ERT) for Mucopolysaccharidosis Type IIIB (Sanfilippo Syndrome Type B).

BiotechHealthtechSouth San Francisco, US

SGSamir Gharib(Executive Officer)inRICHARD KING(Executive Officer, Director)inJSJavier Szwarcberg(Chief Executive Officer)in

BoardSimpson Camilla(Director)TATiba Aynechi(Director)in

Board seatBMBali Muralidhar· per SEC Form D

Co-investorsAIAisling CapitalHEHealthCapRIRiverVest Venture PartnersNONorwest Venture PartnersNONovo HoldingsOMOmega Funds+1 more

Vaxcyte is a biotech company developing vaccines to treat or prevent serious infectious diseases.

BiotechDeep TechHealthtechSouth San Francisco, US

Grant Pickering(Chief Executive Officer, Director and Co-Founder)Jeff Fairman(Vice President of Research and Co-Founder)Ashish Khanna(Executive Officer)

BoardTracy Saxton(Director)William Newell(Director)

Board seatKVKurt von Emster· per SEC Form D

Co-investorsCTCTI Life Sciences Fund L.P.FOForesite CapitalFRFrazier Life SciencesJAJanus Henderson InvestorsLOLongitude CapitalMEMedicxi+4 more

Vera Therapeutics develops medicines targeting autoimmune-driven kidney diseases, with a focus on reducing the need for dialysis or transplant.

BiotechDigital HealthMedical DevicesSouth San Francisco, US

Marshall Fordyce(Executive Officer, Director)in

BoardBSBeth Seidenberg(Director)inMKMaha Katabi(Director)inPEPatrick Enright(Director)inAndrew Cheng(Director)

Board seatKVKurt von Emster· per SEC Form D

Co-investorsKLKleiner PerkinsLOLongitude CapitalSOSofinnova VenturesSOSofinnova Venture Partners

Xilio Therapeutics is a clinical-stage biotechnology company developing masked immuno-oncology therapies that use protein engineering to remain inactive until activated by tumor-specific proteases within the tumor microenvironment.

BiotechHealthtechWaltham, US

RRRené Russo(Executive Officer, Director)inJoseph Farmer(Executive Officer)Timothy Clackson(Executive Officer)Christopher Frankenfield(Chief Financial and Operating Officer)inKLKatarina Luptakova(Chief Medical Officer)inPaul Clancy(Director)

Co-investorsBABain Capital Life SciencesBABay City CapitalF-F-Prime CapitalM M VenturesMRMRL Ventures FundRARA Capital+9 more

Iambic develops AI technologies for drug discovery, using a high-throughput experimental platform to design small-molecule medicines and advance a pipeline of clinical candidates for cancers such as HER2-driven, breast, and ovarian tumors.

AI & Machine LearningBiotechDeep TechSan Diego, US

TMTom Miller(Founder)inFred Manby(Founder)inCZChao Zhang(Executive Officer)inTabbert Teng(Executive Officer)NJNeil Josephson(Chief Medical Officer)inPOPete Olson(Chief Scientific Officer)in

Board seatKVKurt von Emster· per SEC Form D

Co-investorsASAscenta CapitalCACatalio Capital ManagementALAlumni VenturesCACatalio Capital Management, LPCOCoatue ManagementEIEisai Innovation, Inc.+7 more

IFM Therapeutics develops small-molecule drugs that target the innate immune system to treat inflammation-driven diseases and cancer.

BiotechHealthtechCambridge, US

GDGary D. Glick(Founder)inHMH. Martin Seidel(Chief Executive Officer)in

BoardJFJean-Francois Formela(Director)in

Co-investorsATAtlas Venture

Pathalys Pharma is a biotechnology company developing and improving therapeutic treatments for patients with chronic kidney disease.

BiotechHealthtechResearch Triangle Park, US

BSBT Slingsby(Co-Founder & Executive Chairman)in

Co-investorsCACatalys PacificOROrbiMedSASamsara BioCapitalKBKB Investment

Redx is a clinical-stage biotechnology company developing small molecule targeted medicines focused on fibrotic diseases, leveraging ROCK pathway inhibitors and novel targets.

BiotechHealthtechMedical Devices

LALisa Anson(Chief Executive Officer)

BoardBernard Coulie(Independent Director)

Co-investorsREREDMILE5A5AM VenturesPEPerscitus LLPSOSofinnova Partners

Tizona Therapeutics is a biotechnology company developing first-in-class immuno-oncology therapeutics, including its lead clinical-stage asset TTX-080, aimed at changing cancer progression and relapse.

AI & Machine LearningBiotechHealthtech

VKVijay K. Kuchroo(Scientific Co-Founder & Advisory Board Member)Drew Pardoll(Scientific Co-Founder & Advisory Board Member)Dario Vignali(Scientific Co-Founder & Advisory Board Member)Jedd Wolchok(Scientific Co-Founder & Advisory Board Member)COChristine O'Brien(Chief Executive Officer & Board Member)inCBCourtney Beers(Chief Scientific Officer)

Co-investorsCACanaan PartnersMPMPM BioImpactGIGilead SciencesASAstellas Venture Management LLCLILightstone Ventures

AdvanCell is a clinical-stage radiopharmaceutical company developing a pipeline of targeted alpha therapies for the treatment of cancers including prostate, melanoma, ovarian, breast, and lung.

BiotechHealthtechMedical DevicesCambridge, US

AAAndrew Adamovich(Director)inPLPhilina Lee(Executive Officer, Director)inAPAaron Pickett(Executive Officer)in

BoardWing Cheong Lam(Director)Nik Economopoulos(Director)Anthony Aiudi(Director)

Board seatBMBali Muralidhar· per SEC Form D

Co-investorsBABain Capital Life SciencesCACatalio Capital Management, LPPRProto AxiomSASanofi VenturesSVSV Health InvestorsTETenmile+2 more

St. Louis, US

Board seatBMBali MuralidharNMNatalie Mount· per SEC Form D

Co-investorsAIAisling CapitalBIBioGenerator VenturesLYLYZZ CapitalRIRiverVest Venture Partners

CRISPR Therapeutics is a biotechnology company developing gene-based medicines using CRISPR/Cas9 gene-editing technology.

BiotechDeep TechHealthtechZug, CH

Emmanuelle Charpentier(Founder)SKSamarth Kulkarni(Chief Executive Officer and Chairman of the Board)inJRJames R. Kasinger(General Counsel and Secretary)inSKStephen Kennedy(Head of Technical Operations)inMWMegan Wherry Menner(Head of Human Resources)inNPNaimish Patel(Chief Medical Officer)in

Board seatKurt von Emster· per SEC Form D

Co-investorsAVAvoro Capital AdvisorsCLCLI VenturesKHKhosla VenturesNENew Enterprise Associates (NEA)SRSR One Capital ManagementVEVersant Ventures+2 more

GenSight Biologics develops clinical-stage gene therapy treatments, with a lead candidate (GS010/LUMEVOQ) in development for rare genetic diseases.

BiotechDigital HealthHealthtechMedical DevicesParis, FR

BGBernard Gilly(Executive Officer, Director)inJCJean-Philippe Combal(Executive Officer)inThomas Gidoin(Executive Officer)Didier Pruneau(Executive Officer)inNitza Thomasson(Executive Officer)in

BoardFlorent Gros(Director)

Board seatGLGenghis Lloyd-Harris· per SEC Form D

Co-investorsAGAgoranovSOSofinnova Partners

Verona Pharma develops treatments for chronic lung conditions.

BiotechHealthtechLondon

Jan-Anders Karlsson(Executive Officer, Director)inPSPeter Spargo(Executive Officer)inPatrick Humphrey(Director)Ken Cunningham(Director)Kenneth Newman(Executive Officer)Anders Ullman(Director)

Board seatASAndrew Sinclair· per SEC Form D · $200.2M raise · filed Jul 2020

Co-investorsACAccess BiotechnologyAIAisling CapitalANAndera PartnersFOForesite CapitalFRFrazier Life SciencesNENew Enterprise Associates (NEA)+4 more

Allotera (formerly Wugen) develops allogeneic T-cell therapies.

BiotechHealthtechMedical DevicesSt. Louis, US

AKAyman Kabakibi(Executive Officer)inCherry Thomas(Executive Officer)inKSKumar Srinivasan(Executive Officer, Director)inKeith Vendola(Executive Officer)Daniel M Kemp(Executive Officer, Director)Matthew Cooper(Executive Officer)

Board seatBMBali Muralidhar· per SEC Form D

Co-investorsAIAisling CapitalALAlpha Wave GlobalBIBioGenerator VenturesRIRiverVest Venture PartnersFIFidelity InvestmentsLYLYZZ Capital

Addition Therapeutics is a biotechnology company developing therapeutics, led by a scientific and clinical team.

BiotechHealthtechSouth San Francisco, US

KCKathleen Collins(Director)inLKLawrence Kong(Executive Officer)inRPRon Park(President & CEO)inFGFrancine Gregoire(Chief Scientific Officer)inPPPriya Parameswaran(Chief Business Officer)in

BoardJPJayson Punwani(Director)in

Co-investorsBEBEVCPIPivotal Life SciencesSRSR One Capital Management

Algeta was a Norwegian oncology company developing alpha-particle radiopharmaceuticals, notably Xofigo (radium-223 dichloride) for bone metastases in prostate cancer.

Co-investorsADAdvent Life SciencesBIBirk VentureHEHealthCap

Antares Therapeutics discovers and develops precision medicines, with a focus on small molecule therapies targeting previously undruggable oncology targets and other serious diseases.

AI & Machine LearningBiotechMedical DevicesCambridge, US

AFAdam Friedman(Chief Executive Officer)inAFAndrew Fedder(Executive Officer, Director)inBPBrian Piper(Executive Officer, Director)in

Co-investorsATAtlas VentureLILightspeed Venture PartnersVIVida VenturesOMOmega FundsTETenmileALAlleyCorp+1 more

Avedro is an ophthalmic company focused on corneal health, known for bio-activated cross-linking therapies such as the KXL system and riboflavin-based treatments used to address progressive keratoconus.

BiotechHealthtechMedical DevicesWaltham, US

David F. Muller(Executive Officer, Director)inBJBrian J. Roberts(Executive Officer)inRJRhonda J. Bracey(Executive Officer)inThomas W. Burns(Chairman & Chief Executive Officer)

BoardJason Hong(Director)JDJeff Dykan(Director)in

Co-investorsAPAPERTURE Venture PartnersLALAVLILilly Asia VenturesSCSCP Vitalife PartnersTHThird Point VenturesWEWestern Technology Investment+5 more

BiotechNewton Centre, US

Chaime Orlev(Executive Officer)Roni Mamluk(Executive Officer, Director)

BoardScott Minick(Director)inTTTodd T. Foley(Director)inVincent Miles(Director)AKAnsbert K. Gadicke(Director)in

Co-investorsHEHEALTHCARE ROYALTY PARTNERSSOSofinnova VenturesARARCH Venture PartnersMPMPM BioImpact

Gilead Sciences is a biopharmaceutical company headquartered in Foster City, California that discovers, develops, and delivers medicines across virology, oncology, and inflammation.

BiotechHealthtechMedical DevicesNewark, US

Harold Van Wart, Ph. D.(Executive Officer, Director)Pol Boudes(Executive Officer)Charles A. McWherter, Ph. D.(Executive Officer)SSSujal Shah(Executive Officer)

BoardCarl Goldfischer, M.D.(Director)KVKurt von Emster(Director)in

Co-investorsAVAvoro Capital AdvisorsBABay City CapitalFOForesite CapitalVAVantagePoint Capital Partners

Cytospire Therapeutics develops multispecific antibodies and next-generation γδ T cell engagers designed to direct innate and adaptive immune effector cells as an alternative to CD3-based engagers.

BiotechHealthtech

Co-investorsCRCriteria Bio VenturesLILifeArc VenturesMEMedical Incubator Japan K.K.MOModi VenturesPAPathway BioventuresSOSound Bioventures+1 more

Entact is a drug discovery company developing treatments for patients.

BiotechDeep TechWatertown, US

Victoria Richon(Executive Officer, Director, Promoter)inRuben Tommasi(Chief Scientific Officer)Michael Gutch(Chief Operating Officer)Alon Lazarus(Director)

BoardAndrew Sinclair(Director)AFAnna French(Director)in

Co-investorsVEvenBio PartnersARArkin CapitalQIQiming Venture PartnersVEvenBio Global Strategic

Company developing molecules targeting a novel class of receptors for neuro-immuno-inflammatory diseases; acquired by Incyte in May 2024.

BiotechSan Diego, US

Alain Baron(Founder)JeenJoo Kang(Director)Robert Tjian(Director)Marcus Boehm(Founder)

BoardASAndrew Schwab(Director)in

Co-investors5A5AM VenturesAVAvego BioScience CapitalNENew Enterprise Associates (NEA)OUOUP (Osage University Partners)SASanofi VenturesTHThe Column Group+2 more

F2G develops medicines to treat serious fungal diseases where existing therapies have failed or are ineffective.

BiotechDigital HealthHealthtechMedical Devices

Co-investorsADAdvent Life SciencesAIAisling CapitalAMAMR Action FundASAstellas Venture Management LLCBRBrace PharmaSOSofinnova Partners+4 more

Glycomine develops therapeutics for rare diseases, many of which currently lack disease-modifying treatment options.

BiotechSan Francisco, US

Agnes Rafalko(Executive Officer, Director)inSASteven Axon(Chief Executive Officer)inHAHicham Alaoui(Chief Scientific Officer)inRMRose Marino(Chief Medical Officer)inPMPeter McWilliams(Chief Business Officer)GHGeoffrey Hird(Chief Technology Officer)in

Co-investorsADAdvent Life SciencesASAsahi Kasei Corporate Venture CapitalCHChiesi VenturesCTCTI Life Sciences Fund L.P.MIMission Bay CapitalMIMission Biocapital+5 more

BiotechCambridge, US

Magdalene Moran, Ph.D.(Executive Officer)Bert Chenard, Ph.D.(Executive Officer)Russell Herndon(Executive Officer, Director)Tom Burke(Executive Officer)

BoardVincent Miles(Director)JGJean George(Director)

Co-investorsLILightstone VenturesNENew Enterprise Associates (NEA)SASaints CapitalLILilly Ventures

Myricx Bio is a biotech company developing antibody drug conjugates (ADCs) based on N-myristoyltransferases (NMT) inhibitors for cancer treatment.

BiotechMedical DevicesLondon, GB

Co-investorsBRBrandon CapitalBRBrandon Capital PartnersNONovo HoldingsSOSofinnova Partners

Nouscom is a biotech company whose investors page lists its venture capital backers.

BiotechHealthtech

Riccardo Cortese(Co-Founder)Marina Udier(Chief Executive Officer and Board Director)Elisa Scarselli(Chief Scientific Officer and Co-Founder)Alfredo Nicosia(Co-founder)Antonella Folgori(Co-founder)Stefano Colloca(Co-founder)

Co-investors5A5AM VenturesANAndera PartnersANAngelini VenturesRERevelation PartnersXGXGEN VentureBPBpifrance+7 more

Orbus Therapeutics is a clinical-stage biopharmaceutical company developing eflornithine (DFMO), an oral ODC inhibitor, as a cancer therapy.

BiotechHealthtechAptos, US

JLJason Levin(Founder, Director and Chief Executive Officer)Robert M. Myers(Executive Officer, Director)

BoardMichael Wasserman(Director)PEPatrick Enright(Director)inElisha (Terry) Gould(Director)Ernest Mario(Director)

Co-investorsH.H.I.G. BioHealth PartnersH.H.I.G. CapitalH.H.I.G. HealthBridge PartnersLOLongitude CapitalADAdams Street PartnersAGAgent Capital

Pixium Vision SA developed the PRIMA System, an implantable device for treating late-stage macular degeneration, and ran clinical trials in Europe.

BiotechHealthtechMedical Devices

Co-investorsAGAgoranovSOSofinnova PartnersBPBpifranceOMOmnes Capital

Prism operates a recruiting agency that uses AI agents and software to help companies identify job candidates more quickly.

Enterprise SoftwareHR TechLondon, GB

TKTheo Kitsberg(CEO)inALAxel La Pira(CTO)inALAlex Liu(Founder)inRKRajit Khanna(Founder)in

Co-investorsWIWisconsin Investment PartnersY Y CombinatorPAPantera CapitalTETechstarsVAVariant FundVEVela Partners+1 more

Co-investorsF-F-Prime CapitalCUCurie.Bio

Reneo is an asset and investment management platform for decarbonizing residential real estate portfolios in Germany.

Climate TechEnterprise SoftwarePropTechGermany, DE

LBLennart Börner(Founder & Co-CEO)inAGAlexander Graubner-Müller(Founder & Co-CEO)in

Co-investorsFOFoundamentalAIAisling CapitalAMAmzak HealthEUEurazeoLALakestarLULundbeckfonden Ventures+4 more

Xoilac TV is a free online football (soccer) live-streaming platform serving fans in Vietnam, offering Full HD match broadcasts of European, Asian, Vietnamese, and international competitions.

ConsumerMedia & EntertainmentSports Tech

Co-investorsAIAisling CapitalCHChiesi VenturesNENew Enterprise Associates (NEA)PAPappas CapitalRIRiverVest Venture PartnersAMAmzak Health+3 more

Boston-based biotech developing drugs against the 'dark genome'/repeatome for autoimmune disease, cancer and neurodegeneration.

Benjamin Greenbaum(Founder)David Ting(Founder)Rosana Kapeller(Founder)

Co-investorsANAndreessen HorowitzARARCH Venture PartnersGVGV (Google Ventures)LULuma GroupSASanofi VenturesADAdvent Life Sciences+11 more

BiotechBoston, US

AFAdam Friedman(Executive Officer, Director)inGGGary Glick(Executive Officer, Director)inAndrew Fedder(Executive Officer)inDSDarrin Stuart(Executive Officer)inErica Jackson(Executive Officer)inAmanda Valentino(Executive Officer)

Co-investorsATAtlas VentureAVAvoro Capital AdvisorsECEcoR1 CapitalFRFrazier Life SciencesNENextech InvestVIVida Ventures+3 more

StrideBio develops gene therapies based on its STRIVE AAV capsid platform, targeting people with life-threatening diseases.

BiotechHealthtechDurham, US

AAAravind Asokan(Director)inMAMavis Abjandje-McKenna(Director)RSRichard Smith(Executive Officer)inPatrick Ritschel(Executive Officer, Director, Promoter)

Co-investorsHAHatteras Venture PartnersPOPontifax Venture CapitalDEDe Novo VenturesNONorthpond Ventures

An Italian-language affiliate guide that reviews and ranks non-AAMS online casinos (foreign-licensed gambling sites) accessible to Italian players, comparing bonuses, game catalogs, payment methods, and licensing.

ConsumerGamingMedia & EntertainmentBridgewater, US

WDWilliam Duke(Executive Officer)inKPKristine Peterson(Executive Officer, Director)

BoardDaniel Pelak(Director)Sean Traynor(Director)IHIttai Harel(Director)inPaul Queally(Director)

Co-investorsAGAgate Medical Investments LPHLHLM Investment PartnersKAKaiser Permanente VenturesMPMPM BioImpactPIPitangoWEWelsh, Carson, Anderson & Stowe