/Companies

Xilio Therapeutics

NASDAQ: XLO

Waltham, US · Founded 2020 · Delaware corporation · 96 employees on LinkedIn · 16 known investors

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Xilio Therapeutics is a clinical-stage biotechnology company developing masked immuno-oncology therapies that use protein engineering to remain inactive until activated by tumor-specific proteases within the tumor microenvironment. Its approach aims to achieve durable efficacy for cancer patients while avoiding the severe systemic side effects of conventional immuno-oncology agents.

Founders & leadership

Xilio Therapeutics was founded in 2020 by René Russo.

RRRené Russo
René RussoFounder · President and Chief Executive Officer
JF
Joseph FarmerExecutive
TC
Timothy ClacksonExecutive
CFChristopher Frankenfield
Christopher FrankenfieldChief Financial Officer and Chief Operating Officer
KLKatarina Luptakova
Katarina LuptakovaChief Medical Officer2023–2026Katarina Luptakova is a hematologist and oncologist with approximately 20 years of experience in drug development across pharmaceutical and biotech companies, including work on investigational new drug applications, clinical trials, and product registration and launches. She serves as Chief Medical Officer of Xilio Therapeutics.
PC
Paul ClancyNamed on SEC filing
DC
Daniel CurranNamed on SEC filing
NH
Nancy HongBoard Member and Observer2019–2021Investor at San Diego Symphony
RHRachel Humphrey
Rachel HumphreyIndependent Board Director2019–2022Founding Chief Executive Officer at Normunity
DL
Daniel LynchNamed on SEC filing

Board

PDPeter Dudek
Peter DudekBoard Observer2021–2021President at MRL Ventures Fund
DGDavid Grayzel
David GrayzelBoard directorPartner at Atlas Venture

Investors · 16

AbingworthreportedLondon · $15M – $30M

How we know: a partner's Signal profile · Not right? Tell us

Reported raises · per SEC filings

Form D private placements

$145.2M disclosed across 2 of 5 rounds · 1900–2026

▶$95MraisedFeb 2021 · 17 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Rachel HumphreyDirector
  • Andrew HackDirector
  • David GrayzelDirector
  • Daniel LynchDirector
  • Michael RossDirector
  • Joseph FarmerExecutive Officer
  • Rene RussoExecutive Officer, Director
  • Timothy ClacksonExecutive Officer
  • Paul ClancyDirector
  • Daniel CurranDirector
  • David GardnerDirector
Offering amount
$95M
Amount sold
$95M
First sale
Feb 2021
Incorporated
Corporation, Delaware, 2020
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$50.2MraisedJan 2021 · 16 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Paul ClancyDirector
  • Daniel CurranDirector
  • Peter DudekDirector
  • David GrayzelDirector
  • Nancy HongDirector
  • Rachel HumphreyDirector
  • Daniel LynchDirector
  • Michael RossDirector
  • Robert WeisskoffDirector
  • Joseph FarmerExecutive Officer
  • Rene RussoExecutive Officer, Director
  • Timothy ClacksonExecutive Officer
Offering amount
$50.2M
Amount sold
$50.2M
First sale
Jan 2021
Incorporated
Corporation, Delaware, 2020
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

Founder mafia

4 people who came through Xilio Therapeutics went on to found or lead other companies.

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Frequently asked questions

What does Xilio Therapeutics do?
Xilio Therapeutics is a clinical-stage biotechnology company developing masked immuno-oncology therapies that use protein engineering to remain inactive until activated by tumor-specific proteases within the tumor microenvironment. Its approach aims to achieve durable efficacy for cancer patients while avoiding the severe systemic side effects of conventional immuno-oncology agents.
Who founded Xilio Therapeutics?
Xilio Therapeutics was founded by René Russo in 2020.
Who are Xilio Therapeutics's investors?
Xilio Therapeutics's investors include Bain Capital Life Sciences, Bay City Capital, F-Prime Capital, M Ventures, MRL Ventures Fund, RA Capital, RiverVest Venture Partners, Solasta Ventures and 8 more.
How much funding has Xilio Therapeutics raised?
Xilio Therapeutics has disclosed $145.2M raised across 2 of its 5 known rounds.
Where is Xilio Therapeutics headquartered?
Xilio Therapeutics is headquartered in Waltham, US.