Creative Destruction Lab (CDL) — Full Portfolio

Co-investorsFACIT (Fight Against Cancer Innovation Trust)

HealthtechSouth Burlington, US

Robert Skiff(Director)

Kevin Sullivan(Founder)in

Co-investorsConcrete Ventures

4pi Lab develops remote sensing satellites to detect, monitor, and respond to wildfires and their emissions for climate change mitigation.

AI & Machine LearningClimate TechDeep TechSpace Tech

Stephen Achal(Chief Executive Officer, Chief Strategy Officer)Victor Taylor(Chief Technology Officer)

Co-investorsSeraphim Space

Accelerate Wind develops edge-of-roof wind turbine technology for commercial and industrial customers globally, enabling local energy generation by harnessing wind channeled by building structures.

Advanced ManufacturingCleantechClimate TechEnergyHardwareSt. Louis, US

Erika Boeing(Founder & CEO)inSophie Schaffer(Chief Operating Officer)inCharlie Walch(Chief Financial Officer)in

Co-investorsHalogen Ventures Management Company LlcTechstars

Acerta provides an industrial AI analytics platform for discrete manufacturers to identify and resolve production defects early, reducing scrap, rework, and downtime.

Advanced ManufacturingAI & Machine LearningEnterprise Software

Greta Cutulenco(Founder)in

Co-investorsBDC Industrial Innovation Venture FundBDC Thrive Venture Fund for WomenBDC Venture CapitalGarage CapitalM12 (Microsoft's Venture Fund)Stand Up Ventures+1 more

David Hariri(Founder)inMike Murchison(Founder)in

Co-investorsDMZFirstMark CapitalLeaders FundTwo Small Fish VenturesUniversity of Toronto Entrepreneurship HatcheryVersion One Ventures

Adaviv provides AI tools for specialty-crop agriculture that turn field observations into real-time recommendations, helping farm teams optimize labor, inputs, and treatments while reducing waste, crop losses, and rejections.

AgTechAI & Machine LearningSaaS

Ian Seiferling(Founder)in

Co-investorsDelta Emerald VenturesEmerging VenturesNew Stack VenturesREMUS CapitalAiSprouts VC

Adept Materials develops advanced materials for building envelopes that improve energy efficiency, durability, and moisture management without sacrificing comfort.

Advanced ManufacturingCleantechConstruction TechDeep TechNew MaterialsSomerville, US

Derek Stein, Ph.D.(Founder & CEO)Derek Stein(Founder / Inventor)

BoardMiguel Galvez(Director)Daniel Cromie(Director)

Co-investorsAnorak VenturesBantam GroupSlater Technology Fund

Adeptmind builds generative AI tools for retailers, offering AI-powered merchandising, product discovery, personalization, and marketing/ROAS optimization for e-commerce and omnichannel shopping.

AI & Machine LearningE-commerceRetail Tech

Jing He(Founder)inG Wu(Founder)in

Co-investorsDMZInnospark Venturesnoa

AG Data Center builds modular, containerized edge data center infrastructure for deploying AI compute directly at remote sites such as hospitals, universities, utilities, and government facilities.

AI & Machine LearningCleantechClimate TechCloud ComputingData & InfrastructureIoTBeaverton, US

Buchanan Eugene Robert(Executive Officer)

Co-investorsTechstars

A UK-based company developing full-stack photonic quantum computers for applications in aerospace, cybersecurity, defence, energy, pharma and AI.

Deep TechQuantum ComputingSemiconductorsUK, GB

Scott Dufferwiel(Founder)in

Co-investorsDeepbridge CapitalGIMIC Ventures

Co-investorsFront Row Ventures

Affable BPM offers an AI-powered compliance platform for healthcare organizations, combining UniComply for monitoring regulations, policies, contracts, and audits with AffableFLOW for no-code workflow automation and an AI-driven compliance training LMS.

AI & Machine LearningHealthtechSaaS

Co-investorsSybilla Masters

Agnostiq (now part of DataRobot) provides an agent workforce platform for building, operating, and governing enterprise AI agents, including tools like Covalent for orchestrating compute to deploy agents across edge, cloud, or on-prem environments.

AI & Machine LearningCloud ComputingEnterprise Software

Co-investorsDifferential VenturesGreen Egg VenturesScout VenturesScout VenturesBoost VCTensility Venture Partners

ai-coustics provides an audio reliability layer with speech technology such as Voice Focus, which removes background noise and other voices to improve transcription accuracy and keep voice agents responsive in noisy environments.

AI & Machine LearningDeep TechDeveloper ToolsSan Francisco, US

Arne Corvin Jaedicke(Executive Officer, Director, Promoter)Fabian Helmut Seipel(Executive Officer, Director, Promoter)

BoardBORIS GOLDEN(Director)inSitar Teli(Director)in

Co-investorsInovia CapitalAcurio VenturesConnect VenturesConnect VenturesPartech Ventures

Co-investorsFACIT (Fight Against Cancer Innovation Trust)

AiDEN provides an automotive software platform that runs natively on vehicle infotainment screens, using real-time vehicle data to deliver contextual services, automate workflows, and unify fragmented in-car experiences.

AI & Machine LearningMobility & TransportationSaaS

Co-investorsBand of Angels

Co-investorsBDC Fund Investments (Fund-of-Funds)BDC Venture Capital

Aitiologic is a molecular diagnostics and precision medicine company that uses AI-powered bioinformatics to translate disease biology into clinical insight.

AI & Machine LearningBiotechDigital HealthMedical DevicesVienna, AT

Andreas Posch(Founder)inRebecca Ertl(Chief Medical Officer)in

Co-investorsPUSH Ventures

Premier marketplace connecting companies with top sales and business development talent in the United States.

Co-investorsCardinia Ventures

ALAViDA Substance Use is a digital care program for substance use, offering 24/7 access via any device to a specialized care team and clinically-validated activities.

Digital HealthMental HealthWellness & Fitness

Co-investorsPallasite Ventures

Albus Health develops clinically validated monitoring technology that tracks respiratory metrics, heart rate, and cough frequency to support clinical studies.

BiotechDigital HealthHealthtechMedical Devices

Prof Maarten De Vos(Head of R&D)

Co-investorsMeridian Health VenturesParkwalk AdvisorsUCeed Funds

Alexi builds private cloud AI infrastructure for law firms, enabling intelligent systems that connect knowledge, workflows, and data while maintaining client control and security.

AI & Machine LearningEnterprise SoftwareLegalTechToronto, CA

Mark Doble(CEO at Alexi)in

Co-investorsBeresford VenturesDraper AssociatesDrive CapitalFf Venture CapitalForefront VentureTechstars+1 more

Allium manufactures stainless-clad rebar that meets the AASHTO M 329M standard, offered in a full size range (#3–#18) and ASTM A615 and A706 specifications.

Advanced ManufacturingCleantechConstruction TechNew Materials

Steven Jepeal(Cofounder)inSam McAlpine(Founder)in

Co-investorsAera VCAlumni VenturesBay Bridge Ventures ClimateCastor Ventures (an Alumni Ventures Fund)Propeller VC

AlphaOne Robotics develops robotic systems for warehouse and logistics automation, specifically designed to automate truck unloading and palletizing operations.

AI & Machine LearningLogistics & Supply ChainRobotics

Tim Criswell(Founder)inMatt Middleton(Founder)Alex Criswell(Founder)Samarth Rajan(Founder)

AQT develops quantum computers and quantum algorithms to solve complex problems across industries including aerospace, chemistry, materials science, and finance.

Cloud ComputingDeep TechHardwareQuantum ComputingInnsbruck, AT

Thomas Monz(Co-Founder & CEO)inRainer BlattPeter Zoller

Altay Therapeutics develops small molecule inhibitors targeting transcription factors to treat serious diseases including facioscapulohumeral muscular dystrophy and cancer.

BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US

Ali Ozes(Founder)inOsman Ozes(Founder)in

Co-investorsTachyon VenturesY Combinator

Altiroenergy develops clean energy solutions, though the specific products or services are not detailed on the about page.

CleantechClimate TechEnergy

Samson Bowen-Bronet(Chief Executive Officer)Martin Aralov(Chief Technology Officer)Nic Pinkerton(Chief Operating Officer)

BoardProf. Jeff Bergthorson(Chief Scientific Advisor)

Co-investorsHAXUCeed FundsBoxOne Ventures

Altis Labs provides a web-based platform that applies AI models to medical imaging data to generate reproducible predictions and quantifications for clinical trials.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesToronto, CA

Felix Baldauf-Lenschen(Founder & CEO)inJohn(CTO)

Co-investorsDebiopharm Innovation FundFusionOrbiMedBenchstrength Partners

Altrove uses physics-based AI and lab automation to design and manufacture substitutes for critical inorganic materials, aiming to develop alternatives faster than conventional R&D.

Advanced ManufacturingAI & Machine LearningDeep TechEnterprise SoftwareNew MaterialsParis, FR

Thibaud Martin(CEO)inJoonatan Laulainen(CTO)in

Co-investorsContrarian VenturesEmblemEntrepreneur FirstAlvenBpifrance

AlumaPower develops firm, dispatchable power technology aimed at addressing shortfalls in reliable 24/7 electricity for demand from AI data centers, re-industrialization, and electrification.

CleantechClimate TechEnergyHardwareSarnia, CA

Geoffrey Richard Steven Godwin(Director)Rob Alexander(Co-Founder & CEO)inHenk VandenEnde(Co-Founder & EVP, Business Development)inGeoff Sheerin(Inventor, Co-Founder & CTO)Richard Godwin(Co-Founder & Board Member)inPaul Simpson(Co-Founder & Board Member)in

Co-investorsBDC Fund Investments (Fund-of-Funds)BDC Venture CapitalStarbridge Venture Capital LlcBioindustrial Innovation Canada

Ammobia develops a novel ammonia production process that operates at low pressure and low temperature, achieving record-setting conversion rates.

Advanced ManufacturingCleantechEnergySan Francisco, US

Karen Baert(Co-founder & CEO)inTristan Gilbert(Co-founder & CTO)in

Co-investorsChevron Technology VenturesShell VenturesAIR CapitalCastor Ventures (an Alumni Ventures Fund)Collaborative FundMOL Switch+4 more

Ananya Health develops a portable, battery-powered cryoablation platform for treating pre-cancerous cervical lesions at the point of care in any clinic setting.

FemTechHardwareHealthtechMedical DevicesSan Francisco, US

Anu Parvatiyar(Founder)inWei-Hsiang Chang(Director)

Co-investorsY Combinator

Angel City Bio is a physician-scientist founded pharmaceutical company developing bile-acid-based treatments for gastrointestinal diseases, with programs targeting indications such as GLP-1-associated gallbladder disease and Crohn's disease.

BiotechDigital Health

Antora manufactures thermal battery systems for long-duration energy storage, serving manufacturers and data centers seeking to tap into low-cost renewable power.

CleantechEnergyEnterprise SoftwareHardwareSunnyvale, US

Andrew Ponec(Chief Executive Officer, co-founder)inDavid BiermaninJustin BriggsinDavid Bierman, Ph.D.(Chief Commercial Officer, co-founder)Justin Briggs, Ph.D.(Chief Operating Officer, co-founder)

BoardChristina Karapataki(Director)in

Co-investorsTemasekCongruent VenturesFifty YearsGS FuturesISVLoup Ventures+12 more

AOA Dx develops a blood-based liquid biopsy platform using mass spectrometry and machine learning to detect ovarian cancer at early stages through tumor-associated biomarkers in serum.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesDenver, US

Oriana Papin-Zoghbi(Founder)inAlex Fisher(Founder/COO)inAnna Jeter(Founder)inOriana Zoghbi-Harb(Executive Officer, Director)Abigail Mcelhinny(Executive Officer)in

BoardSurbhi Sarna(Director)

Co-investorsAlleyCorpGood Growth CapitalJoyance PartnersY CombinatorAstiaAurum Venture Partners+18 more

Applikate Technologies is a hardware and software company that has built an automated histology platform with integrated digital imaging, which stains and images whole tissue samples without physical slicing to produce histopathology data in hours.

HardwareHealthtechMedical DevicesWashington, US

Richard Torres(Co-founder)inMichael Levene(Co-founder)inDavid Hint(Director)

Aquaai builds bio-inspired, fishlike underwater vehicles equipped with cameras and plug-and-play sensors to collect subsurface water data, offered on a Fish-as-a-Service model.

Climate TechDeep TechRobotics

LianeSimeon P.(Founder)in

Co-investorsAd Astra VenturesBackstage Capital

Aquacycl provides onsite industrial wastewater treatment using its patented technology to treat high-strength wastewater without dilution, offering energy-neutral operation, lower greenhouse gas emissions, and water reuse.

Circular EconomyCleantechClimate TechImpact & Social GoodEscondido, US

Orianna Bretschger(Executive Officer, Director)inMichael Jones(Director)Anil Jha(Director)

Co-investorsAd Astra VenturesNext Wave Impact8090 Industries

Arda engineers plastic-free materials from spent grain sourced from brewers and distillers, using protein hierarchies and nontoxic chemistry.

Advanced ManufacturingBiotechCircular EconomyNew MaterialsLondon, GB

Brett Cotten(CEO)inEdward TJ Mitchell(CTO)in

Co-investorsEntrepreneur FirstOyster Bay Venture CapitalSatganaSerpentine Ventures

Areto Labs offers a responsible AI platform that combines human judgment with AI to detect and filter harmful online content such as hate speech and technology-facilitated gender-based violence, helping global brands and public figures build safer digital communities.

AI & Machine LearningCybersecuritySaaS

Lana(Co-founder)Kasey(Co-founder)Jacqueline Comer(Co-founder)

Co-investorsEdmonton UnlimitedScaleGood Fund LP (powered by TELUS)Startup TNTThe 51 VenturesUCeed FundsUCeed+1 more

Argospace provides launch and transportation services for spacecraft and satellites beyond low Earth orbit (LEO), including cislunar and interplanetary missions.

Deep TechHardwareSpace TechEl Segundo, US

Ryan Carlisle(Founder)inKirby Carlisle(Founder)inRobert Carlisle(Founder)in

Co-investorsAIR CapitalCrosslink CapitalHelios CapitalTFX CapitalType One VenturesBlumberg Capital+1 more

Arkangel connects medical science and artificial intelligence to help healthcare teams make faster clinical decisions and reduce documentation errors.

AI & Machine LearningDigital HealthEnterprise SoftwareHealthtech

Co-investorsBroom Ventures468 Capital

Armilla AI is a managing general agent offering liability coverage, performance warranties, and risk assessments for AI systems.

AI & Machine LearningData & InfrastructureEnterprise SoftwareFintechInsurTechToronto, CA

Dan Adamson(Founder)inKarthik Ramakrishnan(Founder)inBaiju Hasmukhrai Devani(Executive Officer, Director)

BoardRaif Barbaros(Director)in

Co-investorsBeresford VenturesBetaworksDifferential VenturesMS&AD VenturesRebel FundY Combinator+5 more

Arolytics appears to work on emissions detection and monitoring, with a focus case study on methane emissions at oil and gas facilities.

AI & Machine LearningClimate TechEnergySaaS

Co-investorsAccelerate FundBDC Sustainability Venture FundStartup TNTBDC Capital CorporationMetiquity VenturesYaletown Partners

Arylla produces invisible ink tags using nanotechnology that can be applied to fashion products and read via smartphone to enable authentication, traceability, and personalized customer experiences.

Advanced ManufacturingDirect to ConsumerIoTNew MaterialsRoboticsKitchener, CA

Perry Everett(Founder/Business Development)inBenjamin Rasera(Founder)inGraham Thomas(Founder)in

Co-investorsY CombinatorVTF Capital

AgTechIthaca, US

Frank Schroeder(Director)Jay Farmer(Executive Officer, Director)

BoardAlex Bondar(Director)inKyle Welborn(Director)

Co-investorsAcre Venture Partners

Ashored develops fixed-gear fishing technology aimed at reducing marine animal entanglements caused by traditional buoy-and-rope trap systems.

Climate TechHardwareImpact & Social Good

Co-investorsInnovative Solutions Canada

Aspero Medical develops the Pillar balloon overtube solution with micro-textured design to improve control and anchoring during balloon endoscopy for small bowel diagnosis and treatment.

Deep TechHealthtechMedical DevicesBoulder, US

Mark Rentschler(Executive Officer, Director)in

BoardMike Freeman(Director)in

Co-investorsInnosphere VenturesRockies Venture Club

Asynchronics develops NeXosim, a simulation framework for space systems that enables high-fidelity modeling and validation of spacecraft and satellite hardware.

Deep TechDeveloper ToolsSpace Tech

Adam Chikha(Co-Founder & CEO)in

Co-investorsHeartfelt CapitalHEC Paris IncubatorSunfish Partners

Atlas Metrics provides an AI-powered platform that combines non-financial data from multiple sources to help financial institutions manage ESG, climate, and financial risks while automating regulatory reporting and compliance.

AI & Machine LearningClimate TechDeveloper ToolsFintechLondon, GB

Robert Stojnic(CEO)inRoss Taylor(CTO)in

Co-investorsb2ventureBerliner Volksbank VenturesCherry VenturesEntrepreneur FirstKickstart InnovationRedstone+1 more

Atmose builds instruments to measure and condition ultrafine aerosol particles in a range of field locations, addressing gaps in conventional air-quality measurement systems.

CleantechClimate TechHardware

Tyler Johnson(Founder)in

Co-investorsInnovative Solutions Canada

Atomwise uses artificial intelligence and machine learning to discover novel small-molecule drugs, with a current focus on developing treatments for immune and inflammatory diseases.

AI & Machine LearningBiotechDeep TechSan Francisco, US

Izhar Wallach(Executive Officer, Director)inAbraham Heifets(Executive Officer, Director, Promoter)Yan Zhao(Executive Officer)Stephen Worland(Executive Officer, Director)

BoardRobert Mittendorff(Director)inAdam Seabrook(Director)in

Co-investorsAurum Venture PartnersB Capital GroupCerity Partners VenturesDraper AssociatesThreshold VenturesUnruly Capital+5 more

Audette provides a platform for asset and portfolio managers to identify and prioritize building retrofit investments, using data analysis to uncover high-return opportunities that improve net operating income and reduce emissions.

PropTechSaaS

Co-investorsBuoyant Ventures Management, LlcEnergy Impact PartnersForesightModerne VenturesPanache VenturesStepchange+2 more

Aufero Medical develops TruContact, an add-on accessory device that provides on-demand catheter stability during atrial fibrillation ablation procedures.

HardwareHealthtechMedical Devices

Daniel Gelman(Founder & CEO)Maria Drangova(Founder)Allan Skanes(Founder)

Aurora Hydrogen develops microwave-driven methane pyrolysis technology to produce low-cost clean hydrogen without CO₂ emissions.

CleantechClimate TechDeep TechEnergyNew MaterialsEdmonton, CA

Murray Thomsonin

Co-investorsEnergy Innovation Capital

AuX Labs uses precision fermentation to produce recombinant milk proteins, starting with casein, that replicate the functional performance of dairy without animals.

BiotechClimate TechFoodTech

Co-investorsAlwyn CapitalBluestein VenturesCongruent VenturesNàdarra VenturesNatural Products CanadaBuilders VC+2 more

AI-powered platform for accelerated plant breeding using causal genetics to develop crop varieties for commercial and societal needs.

Co-investorsAt One VenturesBlue Bear Capital PartnersGermin8 Ventures

Aview provides multimedia translation and dubbing services to help content creators and entertainers expand their audience internationally across social media platforms.

AI & Machine LearningCreator EconomyMarketing TechMedia & EntertainmentAncaster, CA

Co-investorsTechstarsBoxOne Ventures

Awake Labs provides a digital platform combining smartwatch, mobile, and web dashboard technologies to measure stress in real-time for adults with intellectual or developmental disabilities.

AI & Machine LearningDigital HealthHealthtechIoTMental HealthWellness & FitnessToronto, CA

Co-investorsTechstars

AI-native legal workflow platform automating the full contract lifecycle for legal and financial institutions.

Co-investorsHEC Paris Incubator

Axoft is developing soft, tissue-mimicking neural implants and supporting bidirectional electronics that record and stimulate brain activity through a minimally-invasive burr-hole procedure.

AI & Machine LearningDeep TechMedical DevicesCambridge, US

Paul Le Floch(Executive Officer, Director)inTianyang Ye(Director)inRachel Sha(Director)

BoardChia An Lee(Director)Benjamin Pless(Director)

Co-investorsArcherman CapitalBlindspot Ventures Management CoCastor Ventures (an Alumni Ventures Fund)Safar PartnersThe Engine VenturesAlumni Ventures+2 more

Axonis Therapeutics is a biotechnology company developing small-molecule medicines that target KCC2, a mediator of inhibition in the brain, to treat neurological disorders such as epilepsy and pain.

BiotechDeep TechBoston, US

Shane V. Hegarty(Chief Scientific Officer & Co-Founder)inJoanna Stanicka(Chief Executive Officer, President & Co-Founder)inJeff Imbaro(Chief Operating Officer)inTiasha Shafiq(Chief of Staff)in

BoardCorey . Goodman(Director)inJonathan Leff(Director)in

Co-investorsvenBio PartnersMRL Ventures FundSofinnova VenturesCivilization Ventures Management, LlcHatteras Venture PartnersIaso Ventures+7 more

Ayrton Energy develops a hydrogen storage and transport solution based on a proprietary liquid organic hydrogen carrier (LOHC) and electrochemistry, storing hydrogen as a liquid at ambient conditions so it can be moved using existing fuel infrastructure.

CleantechClimate TechEnergyCalgary, CA

Co-investorsBDC Climate Tech Fund IIClean Energy VenturesForesightThe 51 VenturesThin Air LabsUCeed Funds+3 more

Wellness & FitnessToronto, CA

Co-investorsTechstars

Bairitone develops a wearable patch-based system that maps airway vibrations to detect sleep apnea obstruction causes without MRI, X-ray, or ultrasound.

Digital HealthHealthtechMedical DevicesHouston, US

Onur Kilic(Executive Officer, Director)inMeagan Pitcher(Executive Officer, Director)Brittain Cross(Executive Officer, Director)

Co-investorsGolden SeedsSupermoon Capital

BarrelWise makes the FS1, a device that lets cellar workers measure free SO₂ directly at wine barrels with results uploaded to a cloud database for winemakers and lab teams to analyze.

AgTechHardwareIoT

Co-investorsEmmertech