Creative Destruction Lab (CDL) — Full Portfolio

Kevin Sullivan(Founder)in

Co-investorsCOConcrete Ventures

4pi Lab develops remote sensing satellites to detect, monitor, and respond to wildfires and their emissions for climate change mitigation.

AI & Machine LearningClimate TechDeep TechSpace Tech

SAStephen Achal(Chief Executive Officer, Chief Strategy Officer)inVTVictor Taylor(Chief Technology Officer)

Co-investorsSESeraphim Space

Accelerate Wind develops edge-of-roof wind turbine technology for commercial and industrial customers globally, enabling local energy generation by harnessing wind channeled by building structures.

Advanced ManufacturingCleantechClimate TechEnergyHardwareSt. Louis, US

EBErika Boeing(Founder & CEO)inSSSophie Schaffer(Chief Operating Officer)inCWCharlie Walch(Chief Financial Officer)in

Co-investorsHAHalogen Ventures Management Company LlcTETechstars

Acerta provides an industrial AI analytics platform for discrete manufacturers to identify and resolve production defects early, reducing scrap, rework, and downtime.

Advanced ManufacturingAI & Machine LearningEnergyEnterprise SoftwareKitchener, CA

GCGreta Cutulenco(Founder)in

Co-investorsBDBDC Industrial Innovation Venture FundBDBDC Thrive Venture Fund for WomenBDBDC Venture CapitalGAGarage CapitalL-L-SPARKM1M12 (Microsoft's Venture Fund)+4 more

David Hariri(Founder)inMike Murchison(Founder)in

Co-investorsDMDMZFIFirstMark CapitalLELeaders FundTWTwo Small Fish VenturesUNUniversity of Toronto Entrepreneurship HatcheryVEVersion One Ventures

Adaviv provides AI tools for specialty-crop agriculture that turn field observations into real-time recommendations, helping farm teams optimize labor, inputs, and treatments while reducing waste, crop losses, and rejections.

AgTechAI & Machine LearningSaaS

ISIan Seiferling(Founder)in

Co-investorsDEDelta Emerald VenturesEMEmerging VenturesNENew Stack VenturesREREMUS CapitalAIAiSprouts VC

Adept Materials develops advanced materials for building envelopes that improve energy efficiency, durability, and moisture management without sacrificing comfort.

Advanced ManufacturingCleantechConstruction TechDeep TechNew MaterialsSomerville, US

Derek Stein, Ph.D.(Founder & CEO)Derek Stein(Founder / Inventor)

BoardMiguel Galvez(Director)Daniel Cromie(Director)

Co-investorsANAnorak VenturesBABantam GroupSLSlater Technology Fund

Adeptmind builds generative AI tools for retailers, offering AI-powered merchandising, product discovery, personalization, and marketing/ROAS optimization for e-commerce and omnichannel shopping.

AI & Machine LearningE-commerceRetail Tech

Jing He(Founder)inGWG Wu(Founder)in

Co-investorsDMDMZINInnospark VenturesNOnoa

AG Data Center builds modular, containerized edge data center infrastructure for deploying AI compute directly at remote sites such as hospitals, universities, utilities, and government facilities.

AI & Machine LearningCleantechClimate TechCloud ComputingData & InfrastructureIoTBeaverton, US

Buchanan Eugene Robert(Executive Officer)

Co-investorsTETechstars

A UK-based company developing full-stack photonic quantum computers for applications in aerospace, cybersecurity, defence, energy, pharma and AI.

Deep TechQuantum ComputingSemiconductorsUK, GB

SDScott Dufferwiel(Founder)in

Co-investorsDEDeepbridge CapitalGIGIMIC Ventures

Affable BPM offers an AI-powered compliance platform for healthcare organizations, combining UniComply for monitoring regulations, policies, contracts, and audits with AffableFLOW for no-code workflow automation and an AI-driven compliance training LMS.

AI & Machine LearningHealthtechSaaS

Co-investorsSYSybilla Masters

Agnostiq (now part of DataRobot) provides an agent workforce platform for building, operating, and governing enterprise AI agents, including tools like Covalent for orchestrating compute to deploy agents across edge, cloud, or on-prem environments.

AI & Machine LearningCloud ComputingEnterprise Software

Co-investorsDIDifferential VenturesGRGreen Egg VenturesSCScout VenturesSCScout VenturesBOBoost VCTETensility Venture Partners

ai-coustics provides an audio reliability layer with speech technology such as Voice Focus, which removes background noise and other voices to improve transcription accuracy and keep voice agents responsive in noisy environments.

AI & Machine LearningDeep TechDeveloper ToolsSan Francisco, US

Arne Corvin Jaedicke(Executive Officer, Director, Promoter)Fabian Helmut Seipel(Co-founder & CEO)CJCorvin Jaedicke(Co-founder)in

BoardBGBORIS GOLDEN(Director)inSTSitar Teli(Director)in

Co-investorsINInovia CapitalACAcurio VenturesCOConnect VenturesCOConnect VenturesPAPartech Ventures

AiDEN provides an automotive software platform that runs natively on vehicle infotainment screens, using real-time vehicle data to deliver contextual services, automate workflows, and unify fragmented in-car experiences.

AI & Machine LearningMobility & TransportationSaaS

Co-investorsBABand of AngelsBLBlu Venture InvestorsRSRSCM

Aitiologic is a molecular diagnostics and precision medicine company that uses AI-powered bioinformatics to translate disease biology into clinical insight.

AI & Machine LearningBiotechDigital HealthMedical DevicesVienna, AT

APAndreas Posch(Founder)inRERebecca Ertl(Chief Medical Officer)in

Co-investorsPUPUSH Ventures

Premier marketplace connecting companies with top sales and business development talent in the United States.

Co-investorsCACardinia Ventures

ALAViDA Substance Use is a digital care program for substance use, offering 24/7 access via any device to a specialized care team and clinically-validated activities.

Digital HealthMental HealthWellness & Fitness

Co-investorsPAPallasite Ventures

Albus Health develops clinically validated monitoring technology that tracks respiratory metrics, heart rate, and cough frequency to support clinical studies.

BiotechDigital HealthHealthtechMedical Devices

PMProf Maarten De Vos(Head of R&D)

Co-investorsMEMeridian Health VenturesPAParkwalk AdvisorsUCUCeed Funds

Alexi builds private cloud AI infrastructure for law firms, enabling intelligent systems that connect knowledge, workflows, and data while maintaining client control and security.

AI & Machine LearningEnterprise SoftwareLegalTechToronto, CA

MDMark Doble(CEO at Alexi)in

Co-investorsBEBeresford VenturesDRDraper AssociatesDRDrive CapitalFFFf Venture CapitalFOForefront VentureTETechstars+1 more

Allium manufactures stainless-clad rebar that meets the AASHTO M 329M standard, offered in a full size range (#3–#18) and ASTM A615 and A706 specifications.

Advanced ManufacturingCleantechConstruction TechNew MaterialsPeabody, US

Steven Jepeal(Cofounder)inSam McAlpine(Founder)in

Co-investorsAEAera VCALAlumni VenturesBABay Bridge Ventures ClimateCACastor VenturesPRPropeller VC

AlphaOne Robotics develops robotic systems for warehouse and logistics automation, specifically designed to automate truck unloading and palletizing operations.

AI & Machine LearningLogistics & Supply ChainRobotics

TCTim Criswell(Founder)inMMMatt Middleton(Founder)ACAlex Criswell(Founder)inSRSamarth Rajan(Founder)in

AQT develops quantum computers and quantum algorithms to solve complex problems across industries including aerospace, chemistry, materials science, and finance.

Cloud ComputingDeep TechHardwareQuantum ComputingInnsbruck, AT

TMThomas Monz(Co-Founder & CEO)inRainer BlattPeter Zoller

Altay Therapeutics develops small molecule inhibitors targeting transcription factors to treat serious diseases including facioscapulohumeral muscular dystrophy and cancer.

BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US

AOAli Ozes(Founder)inOOOsman Ozes(Founder)in

Co-investorsTATachyon VenturesY Y Combinator

Altiroenergy develops clean energy solutions, though the specific products or services are not detailed on the about page.

CleantechClimate TechEnergy

Samson Bowen-Bronet(Chief Executive Officer)Martin Aralov(Chief Technology Officer)Nic Pinkerton(Chief Operating Officer)

BoardProf. Jeff Bergthorson(Chief Scientific Advisor)

Co-investorsBOBoxOne VenturesHAHAXUCUCeed FundsUCUCeed

Altis Labs provides a web-based platform that applies AI models to medical imaging data to generate reproducible predictions and quantifications for clinical trials.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesToronto, CA

FBFelix Baldauf-Lenschen(Founder & CEO)inJohn(CTO)

Co-investorsDEDebiopharm Innovation FundFUFusionOROrbiMedBEBenchstrength Partners

Altrove uses machine learning and AI combined with crystal simulation, high-throughput lab experimentation, and materials characterization to discover, synthesize, and scale novel materials as substitutes for vulnerable existing materials.

Advanced ManufacturingAI & Machine LearningDeep TechEnterprise SoftwareNew MaterialsParis, FR

TMThibaud Martin(CEO)inJLJoonatan Laulainen(CTO)in

Co-investorsCOContrarian VenturesEMEmblemENEntrepreneur FirstALAlvenBPBpifrance

AlumaPower develops firm, dispatchable power technology aimed at addressing shortfalls in reliable 24/7 electricity for demand from AI data centers, re-industrialization, and electrification.

CleantechClimate TechEnergyHardwareSarnia, CA

Geoffrey Richard Steven Godwin(Director)RARob Alexander(Co-Founder & CEO)inHVHenk VandenEnde(Co-Founder & EVP, Business Development)inGeoff Sheerin(Inventor, Co-Founder & CTO)RGRichard Godwin(Co-Founder & Board Member)inPSPaul Simpson(Co-Founder & Board Member)in

Co-investorsBDBDC Fund Investments (Fund-of-Funds)BDBDC Venture CapitalSTStarbridge Venture Capital LlcBIBioindustrial Innovation Canada

Ammobia develops a novel ammonia production process that operates at low pressure and low temperature, achieving record-setting conversion rates.

Advanced ManufacturingCleantechEnergySan Francisco, US

KBKaren Baert(Co-founder & CEO)inTGTristan Gilbert(Co-founder & CTO)in

Co-investorsCHChevron Technology VenturesSHShell VenturesAIAIR CapitalCACastor VenturesCOCollaborative FundMOMOL Switch+4 more

Ananya Health develops a portable, battery-powered cryoablation platform for treating pre-cancerous cervical lesions at the point of care in any clinic setting.

FemTechHardwareHealthtechMedical DevicesSan Francisco, US

APAnu Parvatiyar(Founder)inWei-Hsiang Chang(Director)

Co-investorsY Y Combinator

Angel City Bio is a physician-scientist founded pharmaceutical company developing bile-acid-based treatments for gastrointestinal diseases, with programs targeting indications such as GLP-1-associated gallbladder disease and Crohn's disease.

BiotechDigital Health

Antora manufactures thermal battery systems for long-duration energy storage, serving manufacturers and data centers seeking to tap into low-cost renewable power.

CleantechEnergyEnterprise SoftwareHardwareSunnyvale, US

APAndrew Ponec(Chief Executive Officer, co-founder)inDBDavid BiermaninJBJustin BriggsinDavid Bierman, Ph.D.(Chief Commercial Officer, co-founder)Justin Briggs, Ph.D.(Chief Operating Officer, co-founder)

BoardCKChristina Karapataki(Director)in

Co-investorsTETemasekCOCongruent VenturesFIFifty YearsGSGS FuturesISISVLOLoup Ventures+14 more

AOA Dx develops a blood-based liquid biopsy platform using mass spectrometry and machine learning to detect ovarian cancer at early stages through tumor-associated biomarkers in serum.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesDenver, US

OPOriana Papin-Zoghbi(Founder)inAFAlex Fisher(Founder/COO)inAJAnna Jeter(Founder)inOriana Zoghbi-Harb(Executive Officer, Director)AMAbigail Mcelhinny(Executive Officer)in

BoardSSSurbhi Sarna(Director)in

Co-investorsALAlleyCorpGOGood Growth CapitalJOJoyance PartnersY Y CombinatorASAstiaAUAurum Venture Partners+19 more

Applikate Technologies is a hardware and software company that has built an automated histology platform with integrated digital imaging, which stains and images whole tissue samples without physical slicing to produce histopathology data in hours.

HardwareHealthtechMedical DevicesWashington, US

RTRichard Torres(Co-founder)inMLMichael Levene(Co-founder)inDavid Hint(Director)

Aquaai builds bio-inspired, fishlike underwater vehicles equipped with cameras and plug-and-play sensors to collect subsurface water data, offered on a Fish-as-a-Service model.

Climate TechDeep TechRobotics

LianeSimeon P.(Founder)in

Co-investorsADAd Astra VenturesBABackstage Capital

Aquacycl provides onsite industrial wastewater treatment using its patented technology to treat high-strength wastewater without dilution, offering energy-neutral operation, lower greenhouse gas emissions, and water reuse.

Circular EconomyCleantechClimate TechImpact & Social GoodEscondido, US

OBOrianna Bretschger(Executive Officer, Director)inMichael Jones(Director)Anil Jha(Director)

Co-investorsADAd Astra VenturesNENext Wave Impact808090 Industries

Arda engineers plastic-free materials from spent grain sourced from brewers and distillers, using protein hierarchies and nontoxic chemistry.

Advanced ManufacturingBiotechCircular EconomyNew MaterialsLondon, GB

BCBrett Cotten(CEO)inETEdward TJ Mitchell(CTO)in

Co-investorsENEntrepreneur FirstOYOyster Bay Venture CapitalSASatganaSESerpentine VenturesCLClean Growth Fund

Areto Labs offers a responsible AI platform that combines human judgment with AI to detect and filter harmful online content such as hate speech and technology-facilitated gender-based violence, helping global brands and public figures build safer digital communities.

AI & Machine LearningCybersecuritySaaS

Lana(Co-founder)Kasey(Co-founder)JCJacqueline Comer(Co-founder)in

Co-investorsEDEdmonton UnlimitedSCScaleGood Fund LP (powered by TELUS)STStartup TNTTHThe 51 VenturesUCUCeed FundsUCUCeed+1 more

Argospace provides launch and transportation services for spacecraft and satellites beyond low Earth orbit (LEO), including cislunar and interplanetary missions.

Deep TechHardwareSpace TechEl Segundo, US

RCRyan Carlisle(Founder)inKCKirby Carlisle(Founder)inRCRobert Carlisle(Founder)in

Co-investorsAIAIR CapitalCRCrosslink CapitalHEHelios CapitalTFTFX CapitalTYType One VenturesBLBlumberg Capital+1 more

Arkangel connects medical science and artificial intelligence to help healthcare teams make faster clinical decisions and reduce documentation errors.

AI & Machine LearningDigital HealthEnterprise SoftwareHealthtech

Co-investorsBRBroom Ventures46468 Capital

Armilla AI is a managing general agent offering liability coverage, performance warranties, and risk assessments for AI systems.

AI & Machine LearningData & InfrastructureEnterprise SoftwareFintechInsurTechToronto, CA

DADan Adamson(Founder)inKRKarthik Ramakrishnan(Founder)inBaiju Hasmukhrai Devani(Executive Officer, Director)

BoardRBRaif Barbaros(Director)in

Co-investorsBEBeresford VenturesBEBetaworksDIDifferential VenturesMSMS&AD VenturesRERebel FundY Y Combinator+5 more

Arolytics appears to work on emissions detection and monitoring, with a focus case study on methane emissions at oil and gas facilities.

AI & Machine LearningClimate TechEnergySaaS

Co-investorsACAccelerate FundBDBDC Sustainability Venture FundSTStartup TNTBDBDC Capital CorporationMEMetiquity VenturesYAYaletown Partners

Arylla produces invisible ink tags using nanotechnology that can be applied to fashion products and read via smartphone to enable authentication, traceability, and personalized customer experiences.

Advanced ManufacturingDirect to ConsumerIoTNew MaterialsRoboticsKitchener, CA

PEPerry Everett(Founder/Business Development)inBRBenjamin Rasera(Founder)inGTGraham Thomas(Founder)in

Co-investorsY Y CombinatorVTVTF Capital

Ashored develops fixed-gear fishing technology aimed at reducing marine animal entanglements caused by traditional buoy-and-rope trap systems.

Climate TechHardwareImpact & Social Good

Co-investorsINInnovative Solutions Canada

Aspero Medical develops the Pillar balloon overtube solution with micro-textured design to improve control and anchoring during balloon endoscopy for small bowel diagnosis and treatment.

Deep TechHealthtechMedical DevicesBoulder, US

MRMark Rentschler(Co-Founder, CEO)inSteven Edmundowicz, MD(Co-Founder, Chief Medical Officer)

BoardMFMike Freeman(Director)in

Co-investorsINInnosphere VenturesRORockies Venture Club

Asteroid Mining Corporation is an applied sciences firm focused on asteroid mining operations.

Deep TechSpace Tech

Asynchronics develops NeXosim, a simulation framework for space systems that enables high-fidelity modeling and validation of spacecraft and satellite hardware.

Deep TechDeveloper ToolsSpace Tech

ACAdam Chikha(Co-Founder & CEO)in

Co-investorsHEHeartfelt CapitalHEHEC Paris IncubatorSUSunfish Partners

Atlas Metrics provides an AI-powered platform that combines non-financial data from multiple sources to help financial institutions manage ESG, climate, and financial risks while automating regulatory reporting and compliance.

AI & Machine LearningClimate TechDeveloper ToolsFintechLondon, GB

Robert Stojnic(CEO)inRTRoss Taylor(CTO)in

Co-investorsB2b2ventureBEBerliner Volksbank VenturesCHCherry VenturesENEntrepreneur FirstKIKickstart InnovationRERedstone+1 more

Atmose builds instruments to measure and condition ultrafine aerosol particles in a range of field locations, addressing gaps in conventional air-quality measurement systems.

CleantechClimate TechHardware

TJTyler Johnson(Founder)in

Co-investorsINInnovative Solutions Canada

Atomwise uses artificial intelligence and machine learning to discover novel small-molecule drugs, with a current focus on developing treatments for immune and inflammatory diseases.

AI & Machine LearningBiotechDeep TechSan Francisco, US

Izhar Wallach(Executive Officer, Director)inAbraham Heifets(Executive Officer, Director, Promoter)YZYan Zhao(Executive Officer)inStephen Worland(Executive Officer, Director)

BoardRMRobert Mittendorff(Director)inASAdam Seabrook(Director)in

Co-investorsAUAurum Venture PartnersB B Capital GroupCECerity Partners VenturesDRDraper AssociatesTHThreshold VenturesUNUnruly Capital+5 more

Audette provides a platform for asset and portfolio managers to identify and prioritize building retrofit investments, using data analysis to uncover high-return opportunities that improve net operating income and reduce emissions.

PropTechSaaS

Co-investorsBUBuoyant Ventures Management, LlcENEnergy Impact PartnersFOForesightMOModerne VenturesPAPanache VenturesSTStepchange+2 more

Aufero Medical develops TruContact, an add-on accessory device that provides on-demand catheter stability during atrial fibrillation ablation procedures.

HardwareHealthtechMedical Devices

DGDaniel Gelman(Founder & CEO)MDMaria Drangova(Founder)ASAllan Skanes(Founder)

Aurora Hydrogen develops microwave-driven methane pyrolysis technology to produce low-cost clean hydrogen without CO₂ emissions.

CleantechClimate TechDeep TechEnergyNew MaterialsEdmonton, CA

Murray Thomsonin

Co-investorsENEnergy Innovation CapitalCHChevron Technology VenturesSHShell Ventures

AuX Labs uses precision fermentation to produce recombinant milk proteins, starting with casein, that replicate the functional performance of dairy without animals.

BiotechClimate TechFoodTech

Co-investorsALAlwyn CapitalBLBluestein VenturesCOCongruent VenturesNÀNàdarra VenturesNANatural Products CanadaBUBuilders VC+2 more

Aview provides multimedia translation and dubbing services to help content creators and entertainers expand their audience internationally across social media platforms.

AI & Machine LearningCreator EconomyMarketing TechMedia & EntertainmentAncaster, CA

Co-investorsBOBoxOne VenturesTETechstars

Awake Labs provides a digital platform combining smartwatch, mobile, and web dashboard technologies to measure stress in real-time for adults with intellectual or developmental disabilities.

AI & Machine LearningDigital HealthHealthtechIoTMental HealthWellness & FitnessToronto, CA

Co-investorsTETechstars

Axoft is developing soft, tissue-mimicking neural implants and supporting bidirectional electronics that record and stimulate brain activity through a minimally-invasive burr-hole procedure.

AI & Machine LearningDeep TechMedical DevicesCambridge, US

PLPaul Le Floch(Executive Officer, Director)inTYTianyang Ye(Director)inRachel Sha(Director)in

BoardChia An Lee(Director)Benjamin Pless(Director)

Co-investorsARArcherman CapitalBLBlindspot Ventures Management CoCACastor VenturesSASafar PartnersTHThe Engine VenturesALAlumni Ventures+2 more

Axonis Therapeutics is a biotechnology company developing small-molecule medicines that target KCC2, a mediator of inhibition in the brain, to treat neurological disorders such as epilepsy and pain.

BiotechDeep TechBoston, US

SVShane V. Hegarty(Chief Scientific Officer & Co-Founder)inJSJoanna Stanicka(Chief Executive Officer, President & Co-Founder)inJIJeff Imbaro(Chief Operating Officer)inTSTiasha Shafiq(Chief of Staff)in

BoardCorey . Goodman(Director)inJLJonathan Leff(Director)in

Co-investorsVEvenBio PartnersMRMRL Ventures FundSOSofinnova VenturesCICivilization Ventures Management, LlcHAHatteras Venture PartnersIAIaso Ventures+7 more

Ayrton Energy develops a hydrogen storage and transport solution based on a proprietary liquid organic hydrogen carrier (LOHC) and electrochemistry, storing hydrogen as a liquid at ambient conditions so it can be moved using existing fuel infrastructure.

CleantechClimate TechEnergyCalgary, CA

Co-investorsBDBDC Climate Tech Fund IICLClean Energy VenturesFOForesightTHThe 51 VenturesTHThin Air LabsUCUCeed Funds+3 more

Wellness & FitnessToronto, CA

Co-investorsTETechstars

Bairitone develops a wearable patch-based system that maps airway vibrations to detect sleep apnea obstruction causes without MRI, X-ray, or ultrasound.

Digital HealthHealthtechMedical DevicesHouston, US

OKOnur Kilic(Executive Officer, Director)inMeagan Pitcher(Executive Officer, Director)Brittain Cross(Executive Officer, Director)

Co-investorsGOGolden SeedsSOSouth Loop VenturesSUSupermoon Capital

BarrelWise makes the FS1, a device that lets cellar workers measure free SO₂ directly at wine barrels with results uploaded to a cloud database for winemakers and lab teams to analyze.

AgTechHardwareIoT

Co-investorsEMEmmertechAGAg Capital CanadaCOConexus Venture Capital