National Institutes of Health (NIH) — 2018 Investments

Beta Bionics develops the iLet Bionic Pancreas System, an insulin delivery device for people with type 1 diabetes aged 6 and older that requires a physician's prescription.

Digital HealthHealthtechMedical DevicesIrvine, US

Edward Damiano(Executive Officer, Director)Sean Saint(President, Chief Executive Officer and Director)inSFStephen Feider(Chief Financial Officer)inMike Mensinger(Chief Product Officer)inSRSteven Russell(Chief Medical Officer)inMHMark Hopman(Chief Commercial Officer)in

Co-investorsLILifeSci Venture PartnersWEWellington ManagementOMOmega FundsRTRTW Investments L.P.SOSoleus Capital

BillionToOne is a precision diagnostics company that uses molecular counting technology to develop non-invasive prenatal screening and liquid biopsy tests for early disease detection.

BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US

OAOguzhan Atay(Founder)inDTDavid Tsao(CTO)inSSSukrit Silas(Founder)inBrett Huff(Director of Engineering)Mihir Sewak(Software Engineering Manager)Jen Katzburg(Principal Recruiter)

Co-investors50500 Emerging Europe50500 GlobalASAsymmetry VenturesCICivilization Ventures Management, LlcE2e2vcFIFifty Years+24 more

Cartesian Therapeutics is a clinical-stage biotechnology company developing mRNA-based cell therapies aimed at treating autoimmune diseases.

BiotechHealthtechWatertown, US

Metin Kurtoglu(Executive Officer)Omid Farokhzad(Director)CJChris Jewell(Executive Officer)inCBCarsten Brunn(President, CEO & Chairman of the Board)inEmily English(Executive Officer)inBDBlaine Davis(Executive Officer)in

Co-investorsK2K2 HealthVenturesMAMaryland TEDCOSCSchooner CapitalTETEDCO+N+ND CapitalPOPolaris Partners+1 more

Senti Bio develops cell and gene therapies for cancer and difficult-to-treat diseases using synthetic biology and engineered Gene Circuits to enhance precision, control, and selectivity in targeting tumor cells.

BiotechDeep TechMedical DevicesSouth San Francisco, US

TLTim Lu(Co-Founder and Chief Executive Officer)inPLPhilip Lee(Executive Officer)inKanya Rajangam(President, Head of Research & Development and Chief Medical Officer)inYLYvonne Li(Executive Officer)inJames Collins(Director)Timothy Lu(Founder)

Co-investorsEVEvolution VC PartnersFLFlucas VenturesGAGaingelsGRGreen Sands EquityLILifeforce CapitalLILifeSci Venture Partners+14 more

21CM develops advanced biopreservation technologies, including vitrification and cryopreservation solutions, for preserving living systems ranging from mammalian cells to whole organs in biomedical research and clinical applications.

BiotechDeep TechFemTechHealthtechLongevityMedical DevicesFontana, US

Greg Fahy(Chief Scientific Officer)

San Francisco, US

Todd Huffman(Founder)Megan Klimen(Founder)

BoardJoshua Wolfe(Director)MOMatt Ocko(Director)inAGAdam Goulburn(Director)inAdam Goulborn(Director)

Co-investorsCOComet LabsDODolby Family VenturesRERecode VenturesDCDCVC (Data Collective)DIDimension CapitalLULux Capital+1 more

Activated Research Company (ARC), founded in 2014, develops chemical analysis detection technologies such as gas chromatography add-ons (Polyarc and Jetanizer) that improve data accuracy and sample throughput.

Deep TechHardwareNew Materials

Adámas manufactures nanodiamond materials and quantum sensing instrumentation for research and applications in life sciences, biomanufacturing, and nanocomposites.

BiotechDeep TechNew MaterialsQuantum Computing

Dr. Olga Shenderova(President, CTO)Dr. Gary McGuire(Director of Business Development)

BiotechAlameda, US

Michael D. West(President and CEO)Russell Skibsted(Chief Financial Officer)

BoardAlfred Kingsley(Chairman)Michael H. Mulroy(Director)

Quanterix (operating together with Akoya) develops biomarker measurement platforms that combine ultrasensitive blood/CSF liquid immunoassays with spatial tissue proteomics for research and clinical use in neurology, oncology, inflammation, cardiology and infectious disease.

BiotechDigital HealthMedical DevicesBillerica, US

Brian McKelligon(Executive Officer)Garry Nolan(Director)Matthew Winkler(Director)

BoardRHRob Hart(Executive Officer)inRSRobert Shepler(Director)inTRThomas Raffin(Director)in

Co-investorsAMaMoonSTStartXTETelegraph Hill Partners

Alcamena Bio develops an AI-guided peptide discovery platform that combines computational design with high-throughput experimental screening to engineer therapeutic peptides, including those capable of crossing the blood-brain barrier for CNS targets.

AI & Machine LearningBiotechDeep Tech

Alleviant Medical develops an investigational minimally invasive medical device using interatrial shunt therapy to treat heart failure patients, currently in FDA-approved clinical trials (ALLAY-HF and ALLAY-HFrEF).

BiotechHealthtechMedical DevicesAustin, US

Adam Berman(Executive Officer, Director)inJacob Kriegel(Executive Officer, Director)Avni Patel(Executive Officer, Director)Christopher Alex Arevalos(Executive Officer, Director)Albertien Greijdanus(Executive Officer, Director)

BoardGPGeoff Pardo(Director)in

Co-investorsBRBroadview VenturesRIRiverVest Venture PartnersTMTMC Venture FundCACadence Healthcare VenturesGIGilde HealthcareGIGilmartin Capital LLC+3 more

Altis Biosystems builds RepliGut®, human intestinal tissue models grown from human intestinal stem cells that provide human-relevant preclinical data for drug absorption, metabolism, toxicity, and disease modeling.

BiotechDeep TechHealthtechMedical DevicesDurham, US

Christopher Sims(Executive Officer)inJimmy Smedley(Executive Officer)inSamuel Franklin(Director)Joseph McMahon(Director)Michael Biron(Executive Officer, Director)

BoardChristopher Perkins(Director)

Co-investorsATAtlanta Technology AngelsCECentral Texas Angel NetworkCHCheckmate Capital Group LLCCOCowtown AngelsHAHatteras Venture PartnersJOJohnson Venture Partners+2 more

BiotechLa Jolla, US

Gregory Hook(Co-Founder, Vice President Research and Corporate Counsel)inMichael D. Pierschbacher(President and Chief Executive Officer)

BoardBernice Welles(Director)J. Gregory Swendsen(Director)

CAMET (Curated Access to Model-based Engineering Tools) is a subscription library of model-based engineering and analysis plugins for system engineers and architects working on complex cyber-physical and embedded systems.

Deep TechDefense TechDeveloper Tools

CBT Pharma develops cancer therapies and designs clinical trials based on mechanistic and scientific rationale, focused on treating pan-cancer including patients who have exhausted other treatment options.

BiotechHealthtech

HealthtechChantilly, US

OWOlivia Walch(Executive Officer, Director)Daniel Forger(Executive Officer, Director)

BoardMMMichael Masterson(Director)in

Co-investorsHEHealthX VenturesSUSupermoon CapitalINInflect Health

Co-investorsCOConnecticut Innovations

BiotechResearch Triangle Park, US

Robert V. House(Executive Officer, Director, Promoter)Carl N. Kraus(Executive Officer, Director, Promoter)

BoardBarry Garfinkle(Director)Joe McMahon(Director)Joseph W. St. Geme(Director)

Autoimmune Technologies is a biomedical company that licenses and develops diagnostic and therapeutic technologies from Tulane University's School of Medicine.

BiotechHealthtechMedical DevicesNew Orleans, US

Autonomous Healthcare develops autonomous systems for intensive care unit patient monitoring and closed-loop drug delivery management.

AI & Machine LearningDigital HealthHealthtechMedical Devices

Wassim M. Haddad(Co-Founder, Chairman of the Board, Chief Scientific Advisor)Behnood Gholami(Co-Founder, Chief Executive Officer)

Duality provides a platform using privacy-enhancing technologies—such as fully homomorphic encryption, federated learning, and trusted execution environments—that lets organizations analyze and collaborate on sensitive or distributed data and AI models without moving or exposing it.

AI & Machine LearningCybersecurityData & Infrastructure

Axcend builds compact, portable HPLC (high-performance liquid chromatography) instruments, including the Focus LC line with automated sampling, real-time reaction monitoring, and multi-wavelength UV detection.

BiotechDeep TechHardwareSalt Lake City, US

MILTON L LEE(MANAGER)GDGLEN D MELLA(CHIEF EXECUTIVE OFFICER)in

BoardBRANDON D FUGAL(MANAGER)CHRISTOPHER M LEE(MANAGER)

Co-investorsPAPartnership Capital Growth LLC

Behaivior is a digital health company using AI, behavioral health technology, and wearables to improve mental health recovery and crisis prevention for individuals at risk of addiction and mental health crises.

AI & Machine LearningCybersecurityDigital HealthHealthtechMental HealthPittsburgh, US

EGEllie Gordon(Founder)in

Co-investorsTETechstars

BehaviorCloud is a cloud platform for life sciences researchers studying animal behavior and physiology, connecting existing lab instruments to the cloud for remote experiment control and real-time data streaming.

BiotechCloud ComputingSaaS

BiotechHouston, US

Sunil Sharma(Co-Chief Medical Officer)inJPJonathan P. Northrup(President/Secretary/Chief Executive Officer)inAlain Cappeluti(Chief Financial Officer)SHStephen Horrigan(Chief Science Officer)inCasey Cunningham(Co-Chief Medical Officer)

BoardKenneth Carter(Director)

BioMojo develops AI-driven software–hardware systems, including a Human Digital Twin platform and XR-based immersive simulations, to model and optimize human sensorimotor, cognitive, and behavioral performance.

AI & Machine LearningDefense TechHealthtech

BLR Bio develops synthetic peptide therapeutics designed to treat fibro-inflammatory diseases and solid tumors by targeting fibrosis and mechanotransduction pathways.

BiotechHealthtechMedical Devices

C2N Diagnostics develops blood tests for early detection of Alzheimer's disease and cognitive impairment by measuring brain-related biomarkers in patients aged 50+.

BiotechDigital HealthHealthtechMedical DevicesWashington University, US

Joel B. Braunstein(Co-Founder and CEO)David Holtzman(Scientific Co-Founder)Randall Bateman(Scientific Co-Founder)Ilana Fogelman(Co-Founder and Senior Advisor for Medical Innovation)

Cairn Biosciences is a drug discovery company that uses its COMPASS platform to map multiscale cell dynamics and simulate living biology in order to identify novel drug targets and therapeutics.

AI & Machine LearningBiotechHealthtech

Mary Ludlam(Founder & CEO)Payman Amiri(CSO)

Calder Biosciences develops protein-based subunit vaccines using its 3D-Vaxlock technology, which uses dityrosine crosslinking to lock immunogens into the shape they hold on a virus surface for improved antibody responses.

BiotechHealthtechMedical DevicesNYC, US

CMChristopher Marshall(Founder & CEO)inMAMark A. Yondola(Founder & Chief Science Officer)inDPDirk Pleimes(Chief Medical Officer)in

Co-investorsSOSOSV

CaliberMRI develops QA/QC automation software and imaging phantoms that standardize quantitative MRI calibration for research institutions, hospitals, and imaging centers.

AI & Machine LearningDeep TechHardwareHealthtechMedical DevicesBoulder, US

William Hollander(CEO & Founder)

care.coach is a digital health platform that serves elderly individuals and their caregivers through integrated technology, focusing on fall prevention, reducing emergency department visits, and addressing social isolation in Medicare and Medicaid populations.

Digital HealthHealthtechLongevityWellness & Fitness

Victor Wang

Co-investorsAAAARPSTStartUp HealthCACartmell VenturesDADaybreak PartnersTHThird Act VenturesBUBuenavista Equity Partners

CaroGen Corporation develops immunotherapies for cancer and infectious diseases based on an enveloped self-amplifying mRNA (virus-like vesicle) platform, with lead candidates including CARG-2020 for ovarian and other cancers and CARG-201 for hepatitis B.

BiotechHealthtechFarmington, US

BABijan Almassian(CEO)inVNValerian Nakaar(Chief Scientific Officer & Board Member)inDeborah Church(Chief Medical Officer)King Lee(VP, Regulatory Affairs)Timur Yarovinksy(VP, Discovery)Joseph Rininger(VP, Product Development)

Co-investorsCOConnecticut Innovations

Cenoxsys develops breakthrough medications with a focus on drug discovery and development for central nervous system diseases, pain, trauma, and inflammation.

AI & Machine LearningBiotechDeep TechHealthtechMonmouth Junction, US

Daniel E. Benjamin(CEO)Edwin Holland(COO)

BiotechSan Carlos, US

Ramkumar Mandalam(Executive Officer, Director)Stephen Greenberg(Director)Gisela Schwab(Director)Rodney Young(Executive Officer)Richard G. Rathmann(Director)Robby Hogle(Director)

BiotechPittsburgh, US

Eric T. Aherns(Director)Charles F. O'Hanlon, III(Executive Officer, Director)Lourdes M. Castellanos(Executive Officer)T. Ronald Casper(Executive Officer)Eric T. Ahrens(Director)

BoardL. Gerald Tarantino(Director)

Co-investorsPIPittsburgh Life Sciences Greenhouse

Centerline Biomedical develops IOPS®, a 510(k)-cleared endovascular navigation technology that provides real-time 3D image guidance for physicians performing catheterization and other endovascular procedures.

BiotechDeep TechHealthtechMedical DevicesCleveland, US

VGVikash Goel(Executive Officer)inGKGulam Khan(Executive Officer, Director)inIEIndrani Egleston(Executive Officer)inPRPhil Rackliffe(Executive Officer, Director)inVinod K. Goel(Executive Officer)

BoardMichael Whitman(Director)

Co-investorsDEDevice of Tomorrow CapitalJOJobsOhio VenturesJUJumpstart Ventures

Click Therapeutics develops, validates, and commercializes software-based prescription medical treatments, including software-enhanced drug products that combine digital therapeutics with pharmacotherapy.

BiotechDigital HealthHealthtechMedical DevicesNew York, US

DBDavid B. Klein(Founder and CEO)inRSRandall Stanicky(Executive Officer)inAnthony Costello(Director)Bruce Robertson(Director)Douglas Langa(Director)

BoardAlex Zisson(Director)

Co-investorsACAccelmed PartnersH.H.I.G. CapitalH.H.I.G. HealthBridge PartnersHEHealth Catalyst CapitalHIHikma VenturesRERevelation Partners+6 more

CoALA Biosciences supplies coenzymes and enzymatic cofactors for research applications at reduced cost.

BiotechAustin, US

Cogentis discovers and develops first-in-class therapeutic treatments designed to prevent neurodegeneration and restore brain function for patients with conditions including frontotemporal dementia, Parkinson's disease, ALS, and Alzheimer's disease.

BiotechDeep TechLongevityMedical Devices

J. Kent Werner Jr.(Founder and CEO)

Columbus NanoWorks develops customized nanodiamond materials for scientific and industrial applications.

BiotechDeep TechMedical DevicesNew MaterialsQuantum ComputingColumbus, US

Consensus Networks offers a digital asset management dashboard that lets users aggregate and manage cryptocurrencies and NFTs across multiple blockchain protocols, including Ethereum.

Crypto & Web3Data & Infrastructure

Co-investorsELElevate Ventures

San Diego, US

Anders Dale(Director)Chris Airriess(Executive Officer, Director)Guri Stark(Executive Officer, Director)Nathan White(Executive Officer, Director)Thomas Barich(Executive Officer)Paul Mirabella(Director)

CycloPure makes water filtration systems that remove PFAS (per- and polyfluoroalkyl substances) and chlorine from household water supplies.

CleantechClimate TechConsumerHardwareHealthtechImpact & Social GoodNew Materials

Frank Cassou(Founder)

BiotechSudbury, US

Ellen Cordo(Treasurer)Richard Smith(Secretary)James Jenson(Director, President and Chief Executive Officer)

DILIsym provides model-informed drug development (MIDD) software and consulting, covering ADMET prediction, PBPK, pharmacometrics, and QSP/QST for scientists and teams working across the drug development lifecycle.

AI & Machine LearningBiotechSaaS

DreamFace Technologies develops socially assistive robots powered by AI to support chronic care management and healthy aging for older adults.

AI & Machine LearningDigital HealthHealthtechRobotics

Eclipse Orthopaedics is developing the Radioscopic Targeting Attachment (RTA), a freehand targeting and drilling device to help surgeons perform distal locking during intramedullary nail fixation of leg and hip fractures with less operative time and reduced radiation exposure.

Advanced ManufacturingHardwareHealthtechMedical DevicesWarsaw, US

Barry W. Rich(Executive Officer, Director)David B. Rich(Executive Officer, Director, Promoter)

Co-investorsELElevate VenturesFIFirst Leaf Capital

Eko develops FDA-cleared digital stethoscopes and AI-powered software that enables healthcare professionals to detect and diagnose cardiovascular disease with greater accuracy.

AI & Machine LearningDigital HealthHealthtechMedical Devices

CLConnor Landgraf(Co-Founder and CEO)inTCTyler CrouchinJBJason Bellet(Co-Founder and Chief Business Officer)in

Co-investorsQUQuesta CapitalHIHighland Capital PartnersARArtis VenturesBEBetter Ventures Central LlcCACAL InnovationCACalifornia Innovation Fund+16 more

Eliaz Therapeutics develops XGal-3, an investigational therapeutic apheresis device that uses an antibody-based resin to remove the protein Galectin-3 from the bloodstream.

BiotechHealthtechMedical DevicesSanta Rosa, US

Isaac Eliaz(Executive Officer, Director)MGMilton Goss(Executive Officer)

Elimu provides health informatics services and EHR-integrated clinical applications, including clinical decision support rules, quality measures, registries, and care management app suites.

Digital HealthHealthtechMedical Devices

BiotechSan Francisco, US

Eva Martin(CEO, President, CFO, and Secretary)

BoardAndrew Perlman(Director)

ElSohly Laboratories, Inc. provides analytical testing, quality control, consulting, research, and reference/standards work.

BiotechHealthtechOxford, US

Emulate builds Organ-on-a-Chip systems, including platforms, consumables, and pre-assembled BioKits with validated human cell models, to support drug discovery research.

BiotechDeep TechHealthtech

DIDonald Ingber(Founder)inDLDaniel Levner(Co-Founder & CTO)inJCJim Corbett(CEO, Board Member)inLELorna Ewart(Chief Scientific Officer)in

Co-investors+N+ND CapitalNONorthpond VenturesALALS Investment FundALAlumni VenturesALAlwyn CapitalFOFourth Realm+5 more

Endoscopy Assist Devices designs medical devices that enhance endoscopy procedures, specifically polyp traps that improve workflow and specimen collection for healthcare professionals.

HealthtechMedical Devices

Enzyme by Design engineers modified enzymes for medical applications, with particular expertise in developing improved versions of therapeutic proteins like L-asparaginase for cancer treatment.

BiotechDeep TechHealthtechMedical DevicesChicago, US

Arnon Lavie(Co-founder, President, CEO, CSO, Director)Amanda M. Schalk(Co-founder, COO, NIH Grants PI, Director)Gary Gordon(Head of Clinical Development, Director)

Ernest Pharmaceuticals is a biotechnology company developing bacterial therapies to treat advanced solid tumors.

BiotechHealthtech

John Ketchum(Business Advisor)

Fairhaven Health provides science-backed supplements and educational resources designed to support women's health across their lifespan, from menstruation through menopause.

Direct to ConsumerFemTechHealthtechWellness & Fitness

Fawkes Biotechnology develops a diagnostic test for concussion detection and brain health assessment, aiming to transform concussion care globally in the medical diagnostics market.

BiotechDigital HealthMedical Devices

Rob Lewis(CEO)

Fibralign is a Stanford-spinout, commercial-stage company that develops therapeutic medical devices built on its Nanoweave collagen scaffolding technology for tissue engineering and regenerative medicine.

BiotechHardwareHealthtechMedical DevicesNew MaterialsUnion City, US

Greg Kingin

Co-investorsSTStartX

Fischer Imaging develops diagnostic imaging products, continuing a long-standing legacy in the medical imaging field.

HardwareHealthtechMedical Devices

Cell Microsystems develops laboratory instruments and platforms for cell engineering, culture, isolation, and analysis, including single-cell sorting, 3D cell culture, cell counting, tissue dissociation, and automated electrophysiology.

BiotechDeep TechHardware

Co-investorsCLClaremont Creek VenturesMIMission Bay CapitalMIMission BiocapitalSISignet Healthcare PartnersWEWestern Technology Investment

Forcyte Biotechnologies develops drug screening tools that measure cell contractility to identify therapeutic candidates for diseases driven by abnormal cellular force generation, such as asthma, fibrosis, and hypertension.

HealthtechMedical DevicesLos Angeles, US

IPIvan Pushkarsky(Founder)inDDDino Di Carlo(Founder)in

Co-investorsBVBVP InvestorsJUJude GomilaSPSprint VcY Y CombinatorACAcequia Capital (AceCap)ASAsymmetry Ventures+3 more

Cerulean Scientific develops medical devices with a surface technology designed to resist clogging, obstruction, and biofouling, aimed at reducing device failure rates.

Deep TechHealthtechMedical DevicesLancaster, US

Andrew K Jones(Executive Officer, Director)Daniel C Hobson(Executive Officer, Director)

GaitIQ offers a gait analysis solution that assesses walking patterns to support clinical evaluation and diagnosis.

AI & Machine LearningDigital HealthHealthtech

BiotechResearch Triangle Park, US

Amanda Elam(Executive Officer, Director)EBEdward Breitschwerdt(Director)RMRicardo Maggi(Director)B. Jefferson Clark(Executive Officer, Director)NBNicole Bell(Executive Officer, Director)

BoardRichard West(Director)

Co-investorsARArieal Southeast Angel PartnersBOBoston Harbor AngelsWIWisconsin Investment Partners

Gateway Pharm develops a delayed-release metronidazole capsule formulation for treating Clostridioides difficile infections, a leading cause of hospital-associated gastrointestinal illness.

BiotechDigital HealthHealthtechMedical DevicesSt. Louis, US

Lianli Li(Founder and President)

GMS Biotech develops diagnostics and therapeutics solutions, leveraging expertise in biotech commercialization and intellectual property management.

BiotechHealthtechMedical Devices

Krishna Jayaraman(CEO & Co-Founder)Melissa D. Schwaller(VP of Intellectual Property)

Co-investorsSASand Hill Angels

Global Instrumentation designs and manufactures medical devices and digital platforms for cardiac monitoring and electrocardiology, serving healthcare providers and patients globally.

Digital HealthHardwareHealthtechMedical Devices

Jim DeMaso(President)Craig Sellers(Vice President, Regulatory Affairs)Scott Myers(Vice President, Operations & Program Management)

GlycoSurf produces high-purity (>95%) bio-inspired glycolipid and rhamnolipid surfactants using a green chemistry synthetic process, with sugar head-groups including glucose, galactose, and xylose and customizable chain lengths.

BiotechCleantechNew Materials

GlyTR Therapeutics is an early-stage biotech company developing a new class of anti-cancer immunotherapeutic molecules and CAR-T cells.

BiotechHealthtech

Goeppert LLC provides science and technology, research and development, and commercialization services to corporations and US Federal agencies.

Deep TechGovTechNew MaterialsPhiladelphia, US

GreenMark develops non-invasive dental products for dentists, hygienists, and patients that treat tooth sensitivity and support oral health management.

BiotechHealthtechMedical DevicesEast Lansing, US

SBSteven Bloembergen, PhD(Executive Officer, Director)Steven Bloembergen(Executive Officer, Director)

BoardMichael Snyder(Director)Joerg Lahann, Ph.D.(Director)Kenneth Pienta(Director)Frank van Luttikhuizen(Director)

Co-investorsIDID VenturesINInvest MichiganMIMichigan Rise

HabitAware makes Keen2, a vibrating awareness bracelet paired with recovery coaching and an online community to help people manage body-focused repetitive behaviors such as hair pulling, skin picking, and nail biting.

Digital HealthMental HealthWellness & FitnessSaint Louis Park, US

AIAneela Idnani(Executive Officer, Promoter)KKKirk Klobe(Co-founder & CTO)SKSameer Kumar(Co-founder & CEO)JPJohn Pritchard(Co-founder & Lead Hardware Engineer)AIAneela Idnani Kumar(Co-founder & Designer)

Co-investorsBABackstage CapitalSOSOSV

hc1 offers hc1 IQ, an AI-based platform that turns laboratory and diagnostic data into clinical, operational, supply chain, and market-growth intelligence for health systems and providers.

AI & Machine LearningDigital HealthHealthtech

BBBradley Bostic(Chairman and CEO)in

Co-investorsA1A1 Health VenturesELElevate Ventures

HealthMyne develops QIDS, a quantitative imaging and clinical decision support platform for oncology care teams that tracks incidental findings, supports tumor conference preparation, and provides quantitative imaging metrics such as lesion volume and texture analysis.

AI & Machine LearningDigital HealthHealthtechMedical DevicesMadison, US

RCRoger Chylla(Executive Officer, Director)inHao Wang(Executive Officer)inPSPraveen Sinha(Executive Officer, Director)inASArvind Subramanian(Executive Officer, Director)inThomas Rockwell Mackie(Director)

BoardGreg Robinson(Director)

Co-investorsALAlumni VenturesASAscension VenturesBABascom Ventures444490 Ventures

i3 develops a hybrid intravascular imaging catheter combining near-infrared fluorescence (NIRF) and ultrasound (IVUS) sensors to provide real-time molecular and structural imaging during coronary interventions.

AI & Machine LearningDeep TechHealthtechMedical DevicesBoston, US

Co-investorsBRBroadview Ventures

Immusoft develops a cell therapy platform called Immune System Programming (ISP) that engineers a patient's B cells into plasma cells that produce therapeutic proteins after being infused back into the patient.

BiotechDeep TechHealthtechSeattle, US

MSMatthew Scholz(Founder)inSASean Ainsworth(Chief Executive Officer)inRSRobert Sikorski(Chief Medical Officer)RHRob Hayes(Chief Scientific Officer)inSMScott McIvor(Chief Development Officer)Eric Garcia(Executive Officer)in

Co-investorsBIBioRock VenturesBOBoston Harbor AngelsBRBreakout VenturesEQEQx FundINInvariantes FundMIMichigan Capital Network+7 more

Immvention Therapeutics develops first-in-class BACH1 inhibitors intended as an oral therapy for patients with sickle cell disease and other conditions.

BiotechDigital HealthChapel Hill, US

Jenny Ting(Director and Co-founder)Matthew Cohen(Director)Lev Osherovich(Director)Mark Vellaca(Director)Anil Goyal(CEO and Director)

BoardBenjamin Scruggs(Director)

Co-investorsDEDelin VenturesHAHatteras Venture PartnersOUOUP (Osage University Partners)

Imtherapeutics develops oral therapies for Type 1 diabetes patients with specific genetic markers.

Biotech

Co-investorsJDJDRF T1D Fund

ingenious targeting laboratory (iTL) is a U.S.-based company that generates genetically engineered mouse models for biomedical research institutions and pharmaceutical companies.

BiotechDeep TechHealthtechHolbrook, US

Jennifer Parla(Dr.)Milen Kirilov(Dr.)Arielle Bryan(Dr.)

Inimmune is a clinical-stage biotech company developing immunotherapies for allergy, cancer, infectious, and autoimmune diseases.

AI & Machine LearningBiotechDeep TechHealthtechWhitefish, US

Jay EvansinDBDavid BurkhartinHBHelene Bazin-LeeinKRKendal Ryterinalan joslynin

Co-investorsTWTwo Bear Capital

BiotechPortola Valley, US

Lena Wu(Executive Officer, Director)Erik Gentalen(Director)Michael Rubin(Director)

BoardJRJenny Rooke(Director)in

Co-investorsHEHemisphere Ventures LLCVEVertical Venture PartnersGEGenoa VenturesNONorthpond Ventures

Isoformix develops protein isoform assays and biomarker discovery services, with a focus on identifying novel therapeutic targets for Alzheimer's disease.

AI & Machine LearningBiotechDeep TechHealthtechMedical Devices

Dr. Nedelkov(Founder & CEO)

Isolere Bio develops affinity-based reagents and purification platforms for concentrating and purifying viral vectors used in gene therapy, including adeno-associated viruses and lentiviruses.

Advanced ManufacturingBiotechDeep TechNew MaterialsResearch Triangle Park, US

Michael LaBreck(Co-founder)Michael Dzuricky(Director of Advanced R&D)

Co-investorsNONorthpond Ventures

Karamedica develops chitosan-based biomedical technologies for therapeutic applications, particularly focused on Alzheimer's disease and drug delivery systems.

AI & Machine LearningBiotechHealthtechMedical DevicesNew Materials

Andrew Crofton(Chief Executive Officer)Samuel Hudson(Chief Scientific Officer)Taub T Swartz(Chief Financial Officer)

Kinto provides personal care coaching to family caregivers looking after a loved one with dementia, pairing them with a designated Care Coach and offering a curriculum with personalized action plans.

Digital HealthHealthtechWellness & Fitness

Co-investorsTHThe E14 FundBRBrevan Howard Digital

Kromatid provides single-cell structural genomic analysis tools for cell and gene therapy companies, enabling assessment of genomic integrity and identification of complex structural rearrangements during therapy development.

AI & Machine LearningBiotechDeep TechMedical DevicesLongmont, US

Andrew Jost(Executive Officer)James Chomas(Executive Officer, Director)Christopher Tompkins(Executive Officer, Director)Susan Bailey(Executive Officer)Joel Bedford(Director)

BoardTerry Opgenorth(Director)

Co-investorsBRBroadOak Capital Partners

Kuda Therapeutics develops novel cancer therapies targeting hypoxia and HIF signaling pathways.

BiotechHealthtechLongevityMedical DevicesSalt Lake City, US

Dr. Mei Yee Koh(Founder/Director and Chief Executive Officer)Mr. Travis Ehlinger(co-Founder/Director and Chief Financial Officer)

Leuko develops a noninvasive white blood cell monitor to track neutropenia risk in cancer patients and others undergoing treatment.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesBoston, US

IBIan Butterworth(Chief Technology Officer)inABAurelien Bourquard(Chief Data Scientist)inAlvaro Sanchez-Ferro(Chief Medical Officer)inCCCarlos Castro-Gonzalez(Founder)inPHPaul Hartung(Director)in

BoardASAmy Salzhauer(Director)in

Co-investorsGOGood Growth CapitalDODorm RoomMAMassVenturesNINina CapitalIAIAG Capital Partners

LighTopTech develops optical imaging instruments for industrial non-destructive testing and medical applications including surgical guidance.

Advanced ManufacturingDeep TechHardwareHealthtechMedical Devices

Lumen Bioscience develops orally and intranasally delivered biologic drugs and protein-based nutrition products using genetically engineered spirulina algae to express therapeutic proteins such as antibodies, enzymes, and cytokines.

BiotechDeep TechHealthtechSeattle, US

Erik Anderson(Director)Mark Litton(Director)Robert Carlson(Director)Craig Behnke(Executive Officer)Ed Schlect(Director)John Morrow(Executive Officer)

Co-investorsSASamsara BioCapital

Lyssn provides AI-powered tools for behavioral health and child welfare organizations to reduce staff burnout and improve implementation of evidence-based practices.

AI & Machine LearningDigital HealthHealthtechMental HealthSaaSSeattle, US

Zachary E. Imel(Director, Promoter)DCDavid C. Atkins(Executive Officer, Director, Promoter)inMJMichael J. Tanana(Director, Promoter)in

BoardSeth Feuerstein(Director)

Madorra develops a nonhormonal, noninvasive medical device to treat vaginal dryness and vulvovaginal atrophy, targeting post-menopausal people and breast cancer survivors.

FemTechHealthtechMedical DevicesPortland, US

HRHolly Rockweilerin

Co-investorsAVAvestria VenturesBEBerkeley CatalystONOneVenturesPOPortfoliaPOPortland Seed FundSOSocial Starts+2 more

Managed Health Connections develops digital health solutions and customizable research platforms that support substance use disorder treatment, contingency management, screenings, and cognitive impairment tools, integrating with academic and EHR systems.

AI & Machine LearningDigital HealthHealthtech

Kim Johnson(Co-Founder & CEO)Carol Johnson(Co-Founder & CFO)

Manhattan BioSolutions develops targeted biologic agents for treating orphan diseases and areas with unmet medical need.

BiotechDeep TechEnterprise SoftwareHealthtechMedical Devices

Mr. Mohr(Co-founder, BioAsset Advisors)David Yu(Strategic Advisor)John PsaltosBobRonald T. Raines(Firmenich Professor of Chemistry, MIT)

Materna Medical develops medical technologies to address pelvic health needs in obstetrics and gynecology.

FemTechHealthtechMedical DevicesMountain View, US

TMTracy MacNeal(Chief Executive Officer)in

BoardAriella Golomb(Director)Peter Wyles(Director)Arthur Reidel(Director)Jim Bochnowski(Director)Patrick Jamp(Director)

Co-investorsAZAzure Ventures GroupBABand of AngelsCICitrine AngelsGAGaingelsHOHouston Angel NetworkTETexas HALO Fund+2 more

MDI Therapeutics is a pharmaceutical company developing small molecule therapies for fibrosis and fibroproliferative diseases, including MDI-2517, an inhibitor of plasminogen activator inhibitor 1 (PAI-1) currently in a Phase 1 clinical study.

BiotechHealthtechNovi, US

Duane Day(Executive Officer, Director)SBStephen Benoit(Executive Officer, Director)inDaniel Lawrence, Ph.D.(Executive Officer, Director)

Powell, US

Brett P. Thornton(Executive Officer)Gary J. Ross(Executive Officer, Director)

BoardDBDavid Bergeron(Director)

Co-investorsRERev1 Ventures

A retailer of inspirational and religious merchandise including apparel, gifts, home décor, and media products sourced from multiple brand partners.

Consumer

Co-investorsSLSlater Technology Fund

MEI Research designs and manufactures human respiration calorimeters and develops software solutions for health and behavioral research institutions.

AI & Machine LearningDigital HealthHardwareHealthtechMedical Devices

Jon Moon(President and Founder)

MenoGeniX is a clinical-stage biotech company developing a novel treatment for hot flashes and vasomotor symptoms associated with menopause in women.

BiotechFemTechHealthtechAurora, US

Meridian Biotech develops fermentation-based technologies that upcycle low-value by-products from fermentation industries into multi-functional feed ingredients.

AgTechBiotechFoodTech

Charlie Yeh(Founder)in

Co-investorsBLBlue Bear VenturesSOSOSV

Targeting mitochondria for neurodegenerative disease therapies.

BiotechNew York, US

NHNicholas Hertz(Director)Doug Crawford(Director)Daniel de Roulet, Jr.(Executive Officer, Director)

BoardJohannes Fruehauf(Director)

Co-investorsMIMission Bay CapitalMIMission BiocapitalPFPfizer Venture Investments

N8 Medical is a clinical-stage medical device company developing CeraShield, a coating based on antimicrobial compounds called Ceragenins that is applied to indwelling medical devices and implants to prevent hospital-acquired infections.

BiotechHealthtechMedical Devices

NanoMedTrix develops and manufactures nanoparticles for medical applications, particularly targeted cancer therapies that combine diagnostic imaging with drug delivery.

BiotechDeep TechMedical DevicesIowa City, US

Joe Assouline(Founder and Chief Science Officer)Sean Sweeney(Director of Engineering and Manufacturing)

Nature Miri offers zebrafish and related products for research and laboratory applications.

BiotechDeep TechE-commerceHealthtechRetail Tech

BiotechHealthtechOregon City, US

Neil Roundy(Executive Officer, Director, Promoter)Rachel Dreilinger(Executive Officer, Director, Promoter)Coni Rosati(Director, Promoter)

BoardMichael Tippie(Director)

Neurodon develops small-molecule therapeutics that target cellular calcium imbalance and the endoplasmic reticulum stress pathway, using compounds that allosterically modulate the SERCA enzyme to restore calcium transport.

BiotechHealthtechCrown Point, US

Russell Dahl(Executive Officer, Director)BBBrunde Broady(Founder)in

Co-investorsELElevate Ventures

Nokomis develops ADEC, a non-invasive diagnostic system that detects counterfeit, defective, and maliciously modified electronic components and circuit boards by analyzing their unintended radio frequency emissions.

Advanced ManufacturingCybersecurityDeep TechDefense TechHardwareCharleroi, US

NovoPyxis applies mathematics and physics principles, including knot theory and fluid dynamics, to drug design and delivery, predicting protein structures of uncrystallized targets and designing peptide agonists.

BiotechDeep TechMedical DevicesCambridge, US

Daniel Vannoni(Director)RSRaja Srinivas(Director)inMadhavi Gavini(Executive Officer, Director)

Co-investorsBABantam Group

NuShores Biosciences is a medical device company developing first-to-market technologies, with a focus on bone and tissue regeneration and joint replacement applications.

BiotechHealthtechMedical DevicesNew MaterialsLittle Rock, US

Alexandru S. Biris(Co-Founder & CTO)inAGAndrew G. Kumpuris(Founder and Advisor)David E. Anderson(Founder and Advisor; co-founder)inSharon Ballard(Executive Officer, Director)Alex S. Biris(Founder / CTO)

4Saliva provides custom product development services for saliva collection kits and diagnostic testing tools, partnering closely with clients from design through manufacturing and assembly.

Advanced ManufacturingBiotechDigital HealthHealthtechMedical Devices

Oculogica develops FDA-cleared concussion assessment devices that use proprietary eye-tracking technology to measure abnormal eye movements caused by traumatic brain injury.

BiotechDigital HealthHealthtechMedical DevicesNew York, US

RSRosina Samadani(Executive Officer, Director)USUzma Samadani(Director)inRobert Ritlop(Executive Officer)Pratipatti Laxminarain(Director)

BoardJEJill Enos(Director)inKathryn Swintek(Director)in

Co-investorsCOColle Capital PartnersSESeraph GroupSOSoutheast Minnesota Capital FundSTStartXTITitletownTechGOGolden Seeds+1 more

Oleo is a biotech company that develops functional molecules from discovery through commercial-scale production, using a platform to make rare compounds available consistently.

BiotechFoodTechHealthtech

OmicsCraft provides AI-powered software tools and bioinformatics services to biomedical researchers for accelerating disease biomarker discovery.

AI & Machine LearningBiotechCloud ComputingHealthtechWashington, US

Oncotherapy Solutions develops novel peptide drug conjugates and bispecific drug conjugates aimed at treating drug-resistant and metastatic solid tumors.

Biotech

Osteocentric develops orthopedic implant systems for bone fixation, including fasteners, plates, and surgical instruments that use UnifiMI mechanical integration technology.

BiotechHardwareHealthtechMedical DevicesAustin, US

Co-investorsJSJStar Capital Investments

Oxalo Therapeutics is a preclinical-stage biopharmaceutical company developing therapies to treat and prevent diseases caused by hyperoxaluria and hyperoxalemia, such as recurrent calcium oxalate kidney stones.

BiotechHealthtechChicago, US

Yang Zheng(Co-founder, Business lead)inHatim Hassan(Co-founder, R&D lead)

OyaGen is a preclinical drug discovery and development company that identifies and optimizes lead compounds as investigational new drugs for infectious diseases and cancer, then licenses or partners them with industry leaders for clinical development.

BiotechDeep TechHealthtechRochester, US

HCHarold C. Smith(Founder)inRyan P. Bennett(CSO & Laboratory Director)Richard McCloskey(Director)Thomas Fitzgerald(Chief Operations Officer)Richard Ogden(Director)Roscoe Moore(Director)

BiotechKennett Square, US

FMFrank Minella(Executive Officer, Director)inAlexander Ruckdaeschel(Executive Officer, Director)

BoardJohn H. Stewart(Director)Andrew Koopman(Director)

Co-investorsDEDelaware Crossing Investor GroupITItalian Angels for GrowthNYNYU Innovation Venture Fund

Pendar Technologies develops Raman spectroscopy instruments and autonomous chemistry systems for chemical analysis and discovery, including handheld devices for identifying threat materials and tools for real-time reaction kinetics, inspection, authentication, and process control.

Deep TechDefense TechHardware

PhaseBio is a company focused on developing treatments for cardiovascular disease, which is a leading cause of death in the United States.

BiotechHealthtechMedical DevicesMalvern, US

Ashutosh Chilkoti(Director)Joel Sussman(Executive Officer)JMJonathan Mow(Chief Executive Officer)in

BoardJames Barrett(Director)Michael Gutch(Director)Justin Klein(Director)

Co-investorsMOMountain Group CapitalNENew Enterprise Associates (NEA)HAHatteras Venture PartnersJOJohnson & Johnson Innovation – JJDC

PhenoSolve is a company focused on the diagnosis and treatment of medical conditions.

Digital HealthHealthtech

Plumb Pharmaceuticals is a drug delivery startup developing pain and addiction treatments, holding several drug delivery patents.

BiotechMedical DevicesMadison, US

Alex Vodenlich

Point Designs manufactures the Point Digit, a heavy-duty mechanical prosthetic finger designed for individuals with finger loss, featuring a patented ratcheting mechanism that locks into multiple positions for independent finger control.

HardwareHealthtechMedical Devices

Potentiometric Probes develops voltage-sensitive fluorescent dyes (VSDs) that let researchers visualize electrical activity in cells, tissues, and organs such as the brain and heart via microscopy.

BiotechDeep TechMedical Devices

Leslie Loew(Co-Founder)

BiotechDurham, US

JOHN GRIFFIN(Executive Officer)PLPEPPER LANDSON(Executive Officer, Director)in

BoardJOHN MAZUR, MD(Director)

Precision Membranes designs and manufactures reverse osmosis membranes built around a proprietary internal geometry and manufacturing platform intended to improve flow, reduce pressure loss, and lower energy use while keeping the same external drop-in format.

CleantechDeep TechNew Materials

Primetime Life Sciences develops mutual prodrugs that combine existing approved small molecule drugs to improve therapeutic efficacy, safety, and pharmacokinetic characteristics while reducing development time and cost.

BiotechHealthtechLongevityMedical Devices

Prokaryotics is a preclinical antibacterial discovery company developing new classes of antibiotics that target bacterial cell envelope biogenesis to combat multidrug-resistant Gram-negative and Gram-positive bacteria.

BiotechDeep TechHealthtech

Terry Roemer(Founder & CSO)

Co-investorsMPMPM BioImpactVIVida Ventures

Protein Foundry develops molecular tools and production services for chemokines, with expertise in preserving native protein sequences for biological activity.

BiotechDeep TechMilwaukee, US

Dr. Brian F. Volkman(President)Dr. Francis C. Peterson(Vice President)Dr. Michael B. Dwinell(Vice President)

Quantitative BioSciences develops biosensor and immunoassay solutions using microfluidics, synthetic biology, and machine learning for scientific research and government applications.

AI & Machine LearningBiotechDeep TechHardware

Natalie Cookson(Co-founder & CEO)Michael Ferry(Co-founder & CSO)

Reia Health manufactures a collapsible medical-grade silicone pessary for treating pelvic organ prolapse in women, designed for self-insertion and removal at home.

FemTechHealthtechMedical Devices

Kaitlin Maier(CEO)Ariana Sopher(COO)Meegan Daigler(CTO)Paul Hanissian(CMO)

Results Group is a research organization that translates research into solutions and operates Motive Labs, working with university and government research collaborators including NIH, NIDILRR, DHA, CDMRP, MTEC, and the UK NHS-HRA.

Deep TechDefense TechHealthtech

RevBio develops a biomimetic bone adhesive platform derived from marine biology for bone repair and regenerative applications across dental, orthopedic, and neurosurgical indications.

BiotechHealthtechMedical DevicesNew MaterialsLowell, US

BHBrian Hess(Chief Executive Officer, Founder)inDGD. GRAYSON ALLEN(Executive Officer, Director)in

BoardKEVIN FOLEY(Director)GEORGE KAY(Director)

Co-investorsARArieal Southeast Angel PartnersBEBeacon AngelsBOBoston Harbor Angels

Rithim Biologics develops surgical delivery instruments and gene therapies to treat cardiac arrhythmias, including atrial and ventricular rhythm disorders.

BiotechHealthtechMedical DevicesWorcester, US

J. Kevin Donahue(Co-Founder)Ronald L. Anderson

RTC Electronics makes the iPecs Lab, a fully integrated wireless load cell and data logger that measures 3 forces and 3 moments across 6 degrees of freedom, with onboard signal conditioning, data logging, and user-selectable sampling rates.

Deep TechHardwareIoT

SafeTraces develops technology to measure and verify indoor air quality and ventilation performance, aimed at ensuring air safety in indoor environments.

BiotechCleantechDeep TechHardwareHealthtechPleasanton, US

Ulrike Hodges(Director)Antonios Zografos(Executive Officer, Director)John Kraus(Director)Rob Veres(Director)

Co-investorsAGAgility CapitalCICity LightS2S2G InvestmentsBUBungeOMOmidyar Network

SealCath develops the Cephus Catheter, a rectal catheter with dual inflatable balloons designed to instill air or fluid into the colon while creating an airtight seal.

HardwareHealthtechMedical DevicesMount Pleasant, US

Dr. Cephus E. Simmons, Sr.(Founder and CEO)Cephus E. Simmons(Founder and CEO)

Sensimetrics develops software and hearing aid signal processing technologies for individuals with hearing impairment, including noise-reduction algorithms, hearing loss simulations, and assistive listening devices.

AI & Machine LearningDeep TechHardwareHealthtechMedical DevicesCambridge, US

Patrick M. Zurek(President)

Sentiamedical develops therapies targeting the stress response system to address chronic stress and its role in major disease development and healthcare spending.

BiotechDigital HealthHealthtechMedical Devices