Two Bear Capital
Venture capitalActively deployingWhitefish · Pre-Seed–Series B · 45 people tracked
Also known as TWO BEAR CAPITAL SEED
Investment thesis
Two Bear Capital invests in founders with breakthrough ideas aimed at solving urgent and complex problems by leveraging both life sciences and technology. The firm focuses on disruptive sectors where these two domains intersect, seeking opportunities where scientific and technological breakthroughs can scale. Its team is composed of investors, operators, and advisors with deep domain expertise across technology and life sciences. Two Bear Capital emphasizes partnering closely with founders to help transform ambitious ideas into enduring, transformative companies capable of delivering impact on a world-changing scale.
Source: firm website, verified Aug 3, 2026.
Team · 45 people
from the firm's website & public directoriesWhat they invest in
from 21 of 28 portfolio companiesAI & Machine Learning ×12Biotech ×10Data & Infrastructure ×6Enterprise Software ×6Healthtech ×6Cybersecurity ×4Deep Tech ×4Cloud Computing ×3
HQs:United States×14
Investments · showing 27 of 28
founders shown can be your intro pathCIQ is an enterprise infrastructure software company that builds and supports the Linux, HPC, and AI infrastructure stack from the kernel to the orchestrator, serving enterprises, research institutions, and government agencies.
AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsReno, US
Gregory Kurtzer(Founder & CEO)Bjorn Hovland(President)Peter Nelson(Chief Technology Officer)Marlin Prager(CFO)
Sanavia develops cancer therapies—including antibody drug conjugates (ADCs), bispecific T cell engagers, and CAR-T cell therapies—that target novel epitopes in validated cancer targets.
AI & Machine LearningBiotechHealthtech
Arch Systems develops agentic AI software that analyzes factory floor data to provide real-time expert-level guidance to manufacturing teams.
Advanced ManufacturingAI & Machine LearningEnterprise SoftwarePalo Alto, US
Michael Goguen(Director)Jean Francois Clavier(Director)Gus Shahin(Director)Timothy Burke(Executive Officer, Director)Andrew Scheuermann(Executive Officer, Director)
Board seatMichael Goguen· per SEC Form D
San Jose, US
Board seatMichael Goguen· per SEC Form D · $43M raise · filed Jun 2024
BiotechMissoula, US
Sarjubhai Patel(Executive Officer, Director)Brian Conway(Executive Officer)Christopher Booth(Executive Officer, Director)
Board seatAvery SonnenbergMichael Goguen· per SEC Form D · $12M raise · filed Aug 2024
Novoron develops lipoprotein-receptor small molecule therapies aimed at repairing damage and degeneration of the brain and spinal cord, including treatments for proteinopathies and neuroregeneration following traumatic injury.
BiotechDeep TechHealthtechMedical DevicesSan Diego, US
Travis Stiles(CEO & Co-founder)Shawn Gahr(COO & Co-founder)Michael Goguen(Director)David Weiner(Executive Chairman)Ryan McMillian(CFO & Financial Strategy)
Board seatMichael Goguen· per SEC Form D
PulseData is an AI healthcare company that identifies and predicts the progression of cardiorenal and chronic kidney disease using patient data and predictive models.
AI & Machine LearningDigital HealthHealthtechNew York, US
DANIELLE WANG(Director)MICHAEL GOGUEN(Director)HAI PO SUN(Executive Officer, Director)THEODORE CHA(Executive Officer, Director)Hai Po Sun(Co-founder)Teddy Cha(Co-founder)
Board seatMichael Goguen· per SEC Form D · $16.5M raise · filed Apr 2021
R2 Semiconductor develops power management intellectual property and technology for applications ranging from low-power wearables to high-voltage systems, enabling improved efficiency, reduced heat dissipation, and longer battery life in consumer devices and IoT.
HardwareIoTSemiconductorsSunnyvale, US
FAHRI DINER(Director)RICHARD SANQUINI(Director)DENNIS DEBROECK(Executive Officer)ANDREW HARTLAND(Executive Officer)DAVID FISHER(Executive Officer, Director)BOB PAVEY(Director)
Board seatMichael Goguen· per SEC Form D · $10M raise · filed Aug 2015
TileDB builds a database platform for organizing, cataloging, and analyzing large-scale data across organizations.
AI & Machine LearningBiotechCloud ComputingData & InfrastructureEnterprise Software
Abhishek Sharma(Director)Samuel Madden(Director)Stavros Papadopoulos(Executive Officer, Director)Michael Goguen(Director)
Board seatMichael Goguen· per SEC Form D
Enables discovery of novel therapeutics for previously undruggable membrane protein targets.
Abilita Therapeutics is a drug discovery company built on its EMP (Enabled Membrane Proteins) technology, which uses directed evolution to create stability- and expression-enhanced membrane protein variants.
BiotechDeep Tech
Abilita Therapeutics develops drug discovery technology focused on membrane protein targets using its EMP platform based on directed evolution principles.
Biotech
Conceal provides browser security and trusted access that works within any existing browser, protecting users without requiring VPNs, VDIs, proxies, or additional infrastructure.
CybersecurityEnterprise SoftwareSaaSAugusta, US
Brian NeSmith(Director)Spencer Tall(Director)Craig Whetstone(Executive Officer)Ron Gula(Director)Barbara Hunt(Director)Eric Cornelius(Director, Executive Officer)
Gravwell is a security data platform that collects, stores, and analyzes unstructured logs and large data volumes in raw format without enforcing predefined schemas.
CybersecurityData & InfrastructureEnterprise Software
Leading vaccine adjuvant and immunotherapy company utilizing the human immune system for disease prevention and treatment.
Leapfrog develops precision cancer therapies by using its OncoSLX platform to identify genetic vulnerabilities in cancers driven by loss-of-function mutations and repurposing clinical-stage drugs against them.
AI & Machine LearningBiotechHealthtech
Montara Therapeutics is a precision medicine neuroscience biotech developing brain-targeted therapies for neurological diseases via its BrainOnly platform and Brain-Targeting Chimeras (BrainTAC), which aim to concentrate drug activity in the brain and limit peripheral toxicity.
BiotechDeep TechSan Francisco, US
Seth Stratton(Director)Dirk Langdorf(Director)Nicholas Hertz(Executive Officer, Director)
Revenium provides real-time attribution and cost monitoring for AI spend, breaking down every model call, agent turn, and tool call by team, customer, feature, and agent.
AI & Machine LearningCloud ComputingData & InfrastructureFintechSaaS
John(Co-founder (Architecture Lead))Jason(Co-founder (Product Strategy))
Selector builds an AI-driven observability platform that helps operations teams understand and manage complex infrastructure through natural language interaction and contextual intelligence.
AI & Machine LearningData & InfrastructureEnterprise Software
Talus develops a proprietary platform that measures and modulates the regulome—the body's gene expression control system—in native cellular contexts.
AI & Machine LearningBiotechDeep TechHealthtechSeattle, US
Alex Federation(Founder)inLindsay Pino(Founder)in
BoardOmri Amirav-Drory(Director)J. Seth Strattan(Director)
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does Two Bear Capital invest at?
- Two Bear Capital invests at the Pre-Seed, Seed, Series A, Series B stages.
- What is Two Bear Capital's typical check size?
- Two Bear Capital typically writes checks of $3M – $10M.
- What sectors does Two Bear Capital focus on?
- Two Bear Capital focuses on AI & Machine Learning, Biotech, Cybersecurity, Data & Infrastructure, Deep Tech, Digital Health, Healthtech, Longevity.
- Where is Two Bear Capital located?
- Two Bear Capital is headquartered in Whitefish, US.
- Does Two Bear Capital lead rounds?
- Yes, Two Bear Capital leads investment rounds.
Media · Podcasts & interviews
featuring the teamMembers Talk - Mike Goguen - Founder & CEO, Two Bear Capital
FII Institute · Mike Goguen
Hello Whitefish - Cris Neckar - Hacking life / Two Bear Capital (Episode 14)
Hello Whitefish · Cris Neckar
Two Bear Capital: Why Montana, Why Now? Transformational Opportunities in Life Science w Mike Goguen
Montana High Tech Business Alliance · Mike Goguen
Images
Co-investors · 28
AllegisCyber Capital is a venture capital firm focused exclusively on cybersecurity investments, emphasizing deep domain expertise and operating experience.
Atlantic Bridge is a growth equity firm investing in deep technology companies across Europe, the UK and the US, using a cross-border value-add strategy and a global platform to help portfolio companies scale internationally.
Canaan is an early-stage venture capital firm backing founders with transformative ideas across technology and healthcare.
Third Point Ventures is the venture capital arm that invests in and supports technology companies, guiding, coaching, and connecting founders from early to late stage.
Andreessen Horowitz's Strategic Partnerships page describes collaborations that connect its portfolio companies with established institutions to help scale and deploy their technology.
Sequoia Capital is a venture capital firm that partners with founders to build technology companies, with a strong current focus on artificial intelligence.
Greylock Partners is a venture capital firm that backs founders at the earliest stages, often as their first investor before a product exists.
Insight Partners is a venture and growth-stage software investor featuring a large portfolio of technology companies across multiple sectors and regions.
Menlo Ventures is a venture capital firm that backs transformative, early-stage technology companies reshaping how people live and work.
Sapphire Ventures is a venture capital firm founded in 2011 that backs technology companies, offering operating support such as executive talent and customer introductions to its portfolio.
Battery Ventures is a global investment firm that has backed more than 450 companies over its 40-year history, with a team operating as a single global unit and offering focused support services in talent, business development, marketing/communications, and growth/leadership.
Liquid 2 is an early- and growth-stage venture capital firm that invests in founders across all sectors of technology, providing capital along with support from a network of operators.
▶16 more co-investors
Nexus Venture PartnersAccompliceWingUnusual VenturesTenaya CapitalCisco InvestmentsWalden InternationalWestWave CapitalEvolution Equity PartnersS3 VenturesAcrobator VenturesMorgenthalerDag VenturesLumia CapitalEmerald Technology VenturesDigital Horizon VC
Firms observed investing alongside Two Bear Capital, from public investor directories. Shared companies are the overlap with Two Bear Capital's recorded portfolio.
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