Two Bear Capital
Actively deployingPre-Seed–Series B · 16 people tracked
Investment thesis
Two Bear Capital invests in disruptive innovations at sector inflection points. The firm targets biotechnology and bioinformatics, where advances in bioengineering and computational biology are enabling novel disease prevention and treatment approaches. Healthcare IT represents another key focus, as technology-driven companies transform the $3.6 trillion healthcare industry through improved care delivery and cost reduction. The firm is also active in machine learning and artificial intelligence, recognizing the broad economic impact and competitive advantages of companies with strong AI/ML capabilities. Information security is a final area of emphasis, reflecting the critical need for innovative cybersecurity solutions in protecting increasingly valuable digital data.
Source: firm website, verified Jul 20, 2026.
Team · 16 people
from the firm's website
What they invest in
from 6 of 28 portfolio companiesAI & Machine Learning ×3Enterprise Software ×3Biotech ×2Cybersecurity ×2Data & Infrastructure ×2Advanced Manufacturing ×1Cloud Computing ×1Deep Tech ×1
HQs:United States×3
Investments · 28 tracked
founders shown can be your intro pathCIQ is an enterprise infrastructure software company that builds and supports the Linux, HPC, and AI infrastructure stack from the kernel to the orchestrator, serving enterprises, research institutions, and government agencies.
AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsReno, US
Gregory Kurtzer(Founder & CEO)Bjorn Hovland(President)Peter Nelson(Chief Technology Officer)Marlin Prager(CFO)
Enables discovery of novel therapeutics for previously undruggable membrane protein targets.
Abilita Therapeutics develops drug discovery technology focused on membrane protein targets using its EMP platform based on directed evolution principles.
Biotech
Arch Systems develops agentic AI software that analyzes factory floor data to provide real-time expert-level guidance to manufacturing teams. The platform connects operational data to prescriptive actions, helping electronics and discrete manufacturers reduce downtime, improve equipment availability, and optimize throughput without requiring additional dashboards or staff.
Advanced ManufacturingAI & Machine LearningEnterprise Software
Empowers manufacturers with prebuilt data tools to solve problems and improve operations.
Detects and remediates known and unknown vulnerabilities across device and software supply chains.
Provides secure, reliable, and open infrastructure solutions.
Pioneer in browser-native Security Service Edge and proxy-less Zero Trust Network Access technology.
Data access management company enabling organizations to bring data access to where data lives.
Transforms network security with IdentityGraph technology for policy enforcement and deployment.
Develops diagnostic solutions using novel disease insights to create next-generation liquid biopsies.
Provides next-generation network services as an as-a-Service solution for enterprise and hybrid cloud connectivity.
Gravwell is a security data platform that collects, stores, and analyzes unstructured logs and large data volumes in raw format without enforcing predefined schemas. The platform serves security teams and IT departments with advanced search and analytics capabilities under a predictable pricing model.
CybersecurityData & InfrastructureEnterprise Software
Helps organizations detect anomalies, investigate threats, and ensure AI systems function as intended.
Leading vaccine adjuvant and immunotherapy company utilizing the human immune system for disease prevention and treatment.
Accelerates precision oncology to expand treatment options and improve patient outcomes.
Develops safe and efficacious therapies to improve lives of patients with neurological diseases.
Pioneers lipoprotein-receptor drug development to repair central nervous system degeneration.
Provides data-driven, clinically validated predictive insights at the point of care.
Addresses quantum, AI, and classical encryption threats with QuProtect.
QuSecure provides a cryptographic management platform that discovers, remediates, and reports on encryption across cloud, on-premises, and legacy systems. The platform enables organizations to modernize their cryptography and transition to post-quantum encryption standards for enterprise and government customers.
CybersecurityEnterprise SoftwareQuantum ComputingSan Mateo, US
Helps hospitals quantify, capture, and maximize CMS-mandated TEAM incentives.
Turns AI usage into ROI clarity by cutting costs, boosting margins, and providing real-time visibility across models and agents.
Redefines cancer treatment possibilities by harnessing scientific research and breakthrough technologies.
Industry-leading AIOps platform providing real-time actionable insights for managing multi-domain network and application infrastructures.
Enables drug discovery for previously undruggable transcription factors.
Talus develops a proprietary platform that measures and modulates the regulome—the body's gene expression control system—in native cellular contexts. The company designs AI-driven compounds and uses functional proteomics to enable drug discovery for transcription factors and regulatory proteins implicated in oncology, rare disease, and immune dysfunction.
AI & Machine LearningBiotechDeep TechHealthtechSeattle, US
Alex Federation(Founder)inLindsay Pino(Founder)inChristopher JoyceMichelle Briscoe
Multi-modal database that captures all complex analytic applications.
Frequently asked questions
- What stage does Two Bear Capital invest at?
- Two Bear Capital invests at the Pre-Seed, Seed, Series A, Series B stages.
- What is Two Bear Capital's typical check size?
- Two Bear Capital typically writes checks of $3M – $10M.
- What sectors does Two Bear Capital focus on?
- Two Bear Capital focuses on AI & Machine Learning, Biotech, Cybersecurity, Data & Infrastructure, Digital Health.
- Does Two Bear Capital lead rounds?
- Yes, Two Bear Capital leads investment rounds.
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