Fundraising Fox

Two Bear Capital

Venture capitalActively deploying

Whitefish · Pre-Seed–Series B · 45 people tracked

Also known as TWO BEAR CAPITAL SEED

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Investment thesis

Two Bear Capital invests in founders with breakthrough ideas aimed at solving urgent and complex problems by leveraging both life sciences and technology. The firm focuses on disruptive sectors where these two domains intersect, seeking opportunities where scientific and technological breakthroughs can scale. Its team is composed of investors, operators, and advisors with deep domain expertise across technology and life sciences. Two Bear Capital emphasizes partnering closely with founders to help transform ambitious ideas into enduring, transformative companies capable of delivering impact on a world-changing scale.

Source: firm website, verified Aug 3, 2026.

Stage
Pre-Seed–Series B
Check
$3M – $10M
HQ
Whitefish, Montana, US
Leads rounds
Leads
Instruments
Equity
Founded
2019
Tracked investments
28

Team · 45 people

from the firm's website & public directories
J. Seth Strattan· General Partnerin
Ida Khodami· Partnerin
Kristen Getchell· Partner, Head of Platformin
Amalia Colangelo· Principalin
Ryan Castonia· Principalin
Bridget Martell MA, MD· Senior Biopharmaceutical Advisorin
Ellen Lubman· Biopharmaceutical Advisor
Ellen Lubman, MBA· Biopharmaceutical Advisor
James Allison· Nobel Laureate, Chair of Immunology, MD Anderson Cancer Center, University of Texas
James Allison, PhD· Nobel Laureate, Chair of Immunology, MD Anderson Cancer Center, University of Texas
Jeff Miller· Operating Partner, Enterprisein
John Delaney· Senior Biopharmaceutical Advisor
John Delaney, PhD· Senior Biopharmaceutical Advisor
Lavinia Platerink· Associatein
Nikki Johns· VP, Talent Acquisitionin
Padmanee “Pam” Sharma· Professor of Genitourinary Medical Oncology and Immunology, MD Anderson Cancer Center, University of Texas
Padmanee "Pam" Sharma, M.D., PhD· Professor of Genitourinary Medical Oncology and Immunology in the Division of Cancer Medicine, MD Anderson Cancer Center, University of Texas
Zander Mykytiuk· Operating Associatein

What they invest in

from 21 of 28 portfolio companies

AI & Machine Learning ×12Biotech ×10Data & Infrastructure ×6Enterprise Software ×6Healthtech ×6Cybersecurity ×4Deep Tech ×4Cloud Computing ×3

HQs:United States×14

Investments · showing 27 of 28

founders shown can be your intro path
CIQciq.comin𝕏✓ verified

CIQ is an enterprise infrastructure software company that builds and supports the Linux, HPC, and AI infrastructure stack from the kernel to the orchestrator, serving enterprises, research institutions, and government agencies.

AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsReno, US

Gregory Kurtzer(Founder & CEO)Bjorn Hovland(President)Peter Nelson(Chief Technology Officer)Marlin Prager(CFO)

Sanavia Oncologysanavia.bioin✓ verified

Sanavia develops cancer therapies—including antibody drug conjugates (ADCs), bispecific T cell engagers, and CAR-T cell therapies—that target novel epitopes in validated cancer targets.

AI & Machine LearningBiotechHealthtech

Arch Systemsarchsys.ioin

Arch Systems develops agentic AI software that analyzes factory floor data to provide real-time expert-level guidance to manufacturing teams.

Advanced ManufacturingAI & Machine LearningEnterprise SoftwarePalo Alto, US

Michael Goguen(Director)Jean Francois Clavier(Director)Gus Shahin(Director)Timothy Burke(Executive Officer, Director)Andrew Scheuermann(Executive Officer, Director)

Board seatMichael Goguen· per SEC Form D

Elisity, Inc.SEC filingmedium confidence

San Jose, US

Board seatMichael Goguen· per SEC Form D · $43M raise · filed Jun 2024

FYR DiagnosticsSEC filinghigh confidence

BiotechMissoula, US

Sarjubhai Patel(Executive Officer, Director)Brian Conway(Executive Officer)Christopher Booth(Executive Officer, Director)

Board seatAvery SonnenbergMichael Goguen· per SEC Form D · $12M raise · filed Aug 2024

Novoronnovoron.comin

Novoron develops lipoprotein-receptor small molecule therapies aimed at repairing damage and degeneration of the brain and spinal cord, including treatments for proteinopathies and neuroregeneration following traumatic injury.

BiotechDeep TechHealthtechMedical DevicesSan Diego, US

Travis Stiles(CEO & Co-founder)Shawn Gahr(COO & Co-founder)Michael Goguen(Director)David Weiner(Executive Chairman)Ryan McMillian(CFO & Financial Strategy)

Board seatMichael Goguen· per SEC Form D

PULSEDATApulsedata.ioinSEC filingmedium confidence

PulseData is an AI healthcare company that identifies and predicts the progression of cardiorenal and chronic kidney disease using patient data and predictive models.

AI & Machine LearningDigital HealthHealthtechNew York, US

DANIELLE WANG(Director)MICHAEL GOGUEN(Director)HAI PO SUN(Executive Officer, Director)THEODORE CHA(Executive Officer, Director)Hai Po Sun(Co-founder)Teddy Cha(Co-founder)

Board seatMichael Goguen· per SEC Form D · $16.5M raise · filed Apr 2021

R2 Semiconductorr2semi.comSEC filingmedium confidence

R2 Semiconductor develops power management intellectual property and technology for applications ranging from low-power wearables to high-voltage systems, enabling improved efficiency, reduced heat dissipation, and longer battery life in consumer devices and IoT.

HardwareIoTSemiconductorsSunnyvale, US

FAHRI DINER(Director)RICHARD SANQUINI(Director)DENNIS DEBROECK(Executive Officer)ANDREW HARTLAND(Executive Officer)DAVID FISHER(Executive Officer, Director)BOB PAVEY(Director)

Board seatMichael Goguen· per SEC Form D · $10M raise · filed Aug 2015

TileDBtiledb.comin𝕏

TileDB builds a database platform for organizing, cataloging, and analyzing large-scale data across organizations.

AI & Machine LearningBiotechCloud ComputingData & InfrastructureEnterprise Software

Abhishek Sharma(Director)Samuel Madden(Director)Stavros Papadopoulos(Executive Officer, Director)Michael Goguen(Director)

Board seatMichael Goguen· per SEC Form D

Abilita Therapeuticsin

Enables discovery of novel therapeutics for previously undruggable membrane protein targets.

Abilitabioabilitabio.com

Abilita Therapeutics is a drug discovery company built on its EMP (Enabled Membrane Proteins) technology, which uses directed evolution to create stability- and expression-enhanced membrane protein variants.

BiotechDeep Tech

Abilitatxabilitatx.com

Abilita Therapeutics develops drug discovery technology focused on membrane protein targets using its EMP platform based on directed evolution principles.

Biotech

Binarlybinarly.io
Concealconceal.io

Conceal provides browser security and trusted access that works within any existing browser, protecting users without requiring VPNs, VDIs, proxies, or additional infrastructure.

CybersecurityEnterprise SoftwareSaaSAugusta, US

Brian NeSmith(Director)Spencer Tall(Director)Craig Whetstone(Executive Officer)Ron Gula(Director)Barbara Hunt(Director)Eric Cornelius(Director, Executive Officer)

Dymiumdymium.ioin

Dymium provides AI infrastructure with a policy enforcement layer that governs how models, tools, and applications access company data in real time, without copying or relocating the data.

AI & Machine LearningCybersecurityData & Infrastructure

Elisityelisity.comin𝕏

San Jose, US

Brian Thompson(Executive Officer)Brian Long(Director)Michael Goguen(Director)Spencer Tall(Director)James Winebrenner(Executive Officer, Director)Stephen Ward(Director)

Fyr Biofyr.bioin𝕏

FYR develops an AI-enabled multi-omic platform (EV-Omics/EVO) that profiles extracellular vesicles in blood to decode RNA and protein signals for disease detection and characterization.

AI & Machine LearningBiotechMedical Devices

Graphiantgraphiant.comin𝕏
Gravwellgravwell.io

Gravwell is a security data platform that collects, stores, and analyzes unstructured logs and large data volumes in raw format without enforcing predefined schemas.

CybersecurityData & InfrastructureEnterprise Software

Inimmuneinimmune.com

Leading vaccine adjuvant and immunotherapy company utilizing the human immune system for disease prevention and treatment.

Leapfrog Bioleapfrog.bioin

Leapfrog develops precision cancer therapies by using its OncoSLX platform to identify genetic vulnerabilities in cancers driven by loss-of-function mutations and repurposing clinical-stage drugs against them.

AI & Machine LearningBiotechHealthtech

Montara Therapeuticsmontaratx.comin

Montara Therapeutics is a precision medicine neuroscience biotech developing brain-targeted therapies for neurological diseases via its BrainOnly platform and Brain-Targeting Chimeras (BrainTAC), which aim to concentrate drug activity in the brain and limit peripheral toxicity.

BiotechDeep TechSan Francisco, US

Seth Stratton(Director)Dirk Langdorf(Director)Nicholas Hertz(Executive Officer, Director)

PulseDatapulsedata.aiin

PulseData provides patented machine learning and AI healthcare analytics models that predict chronic disease progression, with a focus on kidney disease and end-stage renal disease.

AI & Machine LearningDigital HealthHealthtech

TeddyHai Po

QuSecurequsecure.comin𝕏

QuSecure provides a cryptographic management platform that discovers, remediates, and reports on encryption across cloud, on-premises, and legacy systems.

CybersecurityEnterprise SoftwareQuantum ComputingSan Mateo, US

Reveniumrevenium.aiin

Revenium provides real-time attribution and cost monitoring for AI spend, breaking down every model call, agent turn, and tool call by team, customer, feature, and agent.

AI & Machine LearningCloud ComputingData & InfrastructureFintechSaaS

John(Co-founder (Architecture Lead))Jason(Co-founder (Product Strategy))

Selector AIselector.aiin𝕏

Selector builds an AI-driven observability platform that helps operations teams understand and manage complex infrastructure through natural language interaction and contextual intelligence.

AI & Machine LearningData & InfrastructureEnterprise Software

Talus Biotalus.bioin𝕏

Talus develops a proprietary platform that measures and modulates the regulome—the body's gene expression control system—in native cellular contexts.

AI & Machine LearningBiotechDeep TechHealthtechSeattle, US

Alex Federation(Founder)inLindsay Pino(Founder)in

BoardOmri Amirav-Drory(Director)J. Seth Strattan(Director)

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Frequently asked questions

What stage does Two Bear Capital invest at?
Two Bear Capital invests at the Pre-Seed, Seed, Series A, Series B stages.
What is Two Bear Capital's typical check size?
Two Bear Capital typically writes checks of $3M – $10M.
What sectors does Two Bear Capital focus on?
Two Bear Capital focuses on AI & Machine Learning, Biotech, Cybersecurity, Data & Infrastructure, Deep Tech, Digital Health, Healthtech, Longevity.
Where is Two Bear Capital located?
Two Bear Capital is headquartered in Whitefish, US.
Does Two Bear Capital lead rounds?
Yes, Two Bear Capital leads investment rounds.

Media · Podcasts & interviews

featuring the team

Members Talk - Mike Goguen - Founder & CEO, Two Bear Capital

FII Institute · Mike Goguen

Hello Whitefish - Cris Neckar - Hacking life / Two Bear Capital (Episode 14)

Hello Whitefish · Cris Neckar

Two Bear Capital: Why Montana, Why Now? Transformational Opportunities in Life Science w Mike Goguen

Montana High Tech Business Alliance · Mike Goguen

Images

Two Bear Capital photoTwo Bear Capital photoTwo Bear Capital photoTwo Bear Capital photoTwo Bear Capital photoTwo Bear Capital photo

Co-investors · 28

AllegisCyber Capital

AllegisCyber Capital is a venture capital firm focused exclusively on cybersecurity investments, emphasizing deep domain expertise and operating experience.

Both backed · 2
$3M – $5M
Atlantic Bridge Ventures

Atlantic Bridge is a growth equity firm investing in deep technology companies across Europe, the UK and the US, using a cross-border value-add strategy and a global platform to help portfolio companies scale internationally.

Both backed · 2
$1M – $5M
Canaan Partners

Canaan is an early-stage venture capital firm backing founders with transformative ideas across technology and healthcare.

Both backed · 1
Binarly
$500K – $20M
Third Point Ventures

Third Point Ventures is the venture capital arm that invests in and supports technology companies, guiding, coaching, and connecting founders from early to late stage.

Both backed · 1
Andreessen Horowitz

Andreessen Horowitz's Strategic Partnerships page describes collaborations that connect its portfolio companies with established institutions to help scale and deploy their technology.

$500K – $50M
Sequoia Capital

Sequoia Capital is a venture capital firm that partners with founders to build technology companies, with a strong current focus on artificial intelligence.

$4.4M – $214M
Greylock Partners

Greylock Partners is a venture capital firm that backs founders at the earliest stages, often as their first investor before a product exists.

$100K – $200M
Insight Partners

Insight Partners is a venture and growth-stage software investor featuring a large portfolio of technology companies across multiple sectors and regions.

$120M – $350M
Menlo Ventures

Menlo Ventures is a venture capital firm that backs transformative, early-stage technology companies reshaping how people live and work.

$1M – $20M
Sapphire Ventures

Sapphire Ventures is a venture capital firm founded in 2011 that backs technology companies, offering operating support such as executive talent and customer introductions to its portfolio.

$5M – $20M
Battery Ventures

Battery Ventures is a global investment firm that has backed more than 450 companies over its 40-year history, with a team operating as a single global unit and offering focused support services in talent, business development, marketing/communications, and growth/leadership.

$500K – $100M
Liquid Ventures

Liquid 2 is an early- and growth-stage venture capital firm that invests in founders across all sectors of technology, providing capital along with support from a network of operators.

$250K – $5M
16 more co-investors

Nexus Venture PartnersAccompliceWingUnusual VenturesTenaya CapitalCisco InvestmentsWalden InternationalWestWave CapitalEvolution Equity PartnersS3 VenturesAcrobator VenturesMorgenthalerDag VenturesLumia CapitalEmerald Technology VenturesDigital Horizon VC

Firms observed investing alongside Two Bear Capital, from public investor directories. Shared companies are the overlap with Two Bear Capital's recorded portfolio.

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