/Investor DB

Catalytic Impact Foundation

Foundation

Hingham · Pre-Seed–Series A · 8 people tracked

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Investment thesis

The foundation accelerates innovation in life sciences and healthcare by deploying philanthropic capital into early-stage companies developing transformative, life-sustaining technologies. It targets the funding gap known as the 'Valley of Death' between research grants and commercial investment. Investments focus on six underfunded verticals: children's health, brain and mental health, women's health, rare diseases, health equity, and healthy aging. Its capital is catalytic, aiming to validate technologies and teams to attract further investment while helping companies advance toward FDA approval. The foundation also prioritizes women-led companies, citing their strong returns despite receiving little venture funding.

Source: firm website, verified Oct 2, 2026.

Stage
Pre-Seed–Series A
HQ
Hingham, US
Instruments
Equity · Grants
Founded
2015
Tracked investments
57
Unicorns
1

Team · 8 people

from the firm's website
Rachel Butler· Board Director and President
Richard Lipkin· Board Director and Founder
David Danar· Life Sciences Executive, Biotechnology and Device Consulting

Physician and life sciences executive focused on biotechnology and medical device consulting.

Ellen Itskovitz· Healthcare Industry Analyst and Institutional Investment Consultant

Healthcare industry analyst and institutional investment consultant on the investment team.

Krista Hager· Communications and Operations
Michael Paas· Life Sciences Executive, Biopharmaceutical and Strategy Consulting

Life sciences executive with biopharmaceutical and strategy consulting experience.

Susana Frazao Pinheiro· Board Director; Investment Advisor to the EU and European Innovation Funds

Board director who also advises on investment for the EU and European Innovation Funds.

What they invest in

from 20 of 57 portfolio companies

Healthtech ×10Biotech ×9Medical Devices ×8AI & Machine Learning ×7Digital Health ×6FemTech ×4Advanced Manufacturing ×1Cleantech ×1

HQs:United States×17Ireland×1

Who they back

founder profiles across 14 portfolio companies
21%
solo founders
3 of 14 mapped founding teams
18%
repeat founders
of 17 founders with career history

Founding team size:solo founder×32 founders×73 founders×4

Where their founders studiedfrom 14 founders with education data

Massachusetts Institute of Technology ×3Columbia University ×2Sapienza Università di Roma ×2

What their founders studiedfrom 15 founders with field-of-study data

Engineering ×5Business & Management ×4Computer Science ×4Economics ×2Finance & Accounting ×2Humanities ×2Medicine ×2

Where their founders worked beforefrom 17 founders with career history

Google ×2Polaris Partners ×2SUNY Downstate Medical Center ×2

Investments · 57 tracked

founders shown can be your intro path

By year:2025 · 12017 · 12 dated

Airfoxcbinsights.comin𝕏

CB Insights provides a market intelligence platform that offers verified data, analytics, and predictive scoring on over 12 million private and public companies.

AI & Machine LearningData & InfrastructureSaaS

Co-investorsAlumni VenturesBasecamp FundCartaCRV (Charles River Ventures)Essentia VenturesInCountry+7 more

AOA Dxaoadx.comin𝕏Seed

AOA Dx develops a blood-based liquid biopsy platform using mass spectrometry and machine learning to detect ovarian cancer at early stages through tumor-associated biomarkers in serum.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesDenver, US

Oriana Papin-Zoghbi(Founder)inAlex Fisher(COO)inAnna Jeter(Founder)inOriana Zoghbi-Harb(Executive Officer, Director)Abigail Mcelhinny(Executive Officer)inRob Mayers(Recruiter)

Co-investorsAlleyCorpGood Growth CapitalJoyance PartnersY CombinatorAstiaAurum Venture Partners+37 more

Applied Intuitionappliedintuition.comin𝕏

Applied Intuition develops physical AI software for autonomous and intelligent machines, including vehicles, robots, ships, and satellites across industries like automotive, defense, logistics, and manufacturing.

AI & Machine LearningDeep TechDeveloper ToolsEnterprise SoftwareRoboticsSunnyvale, US

Qasar Younis(Founder)inPeter Ludwig(Founder)inQasar Younis Peter Ludwig(Founder)

Co-investors137 VenturesAndreessen HorowitzBond Capital ManagementCoatue ManagementElad GilEQUIAM+33 more

Bloomer Techbloomertech.comin

Bloomer Tech develops digital biomarkers and precision cardiovascular care built around female physiology.

Digital HealthFemTechMedical Devices

Alicia Chong Rodriguez(Founder & CEO)inAceil Halaby(Founder & COO)in

Co-investorsMaterial Impact

Cleerlycleerly.comin𝕏

Cleerly develops FDA-cleared, AI-driven analysis of noninvasive coronary CT (CCTA) imaging to characterize and quantify coronary artery disease.

AI & Machine LearningDigital HealthHealthtechMedical DevicesDenver, US

James Min, MD(Founder)inJames K. Min(Founder)

BoardLee Cooper(Director)Peter Justin Klein(Director)Scott Barclay(Director)inLouis Samson(Director)

Co-investorsBattery VenturesBreyer CapitalDigiTx Partners LLCEsplanade VenturesInsight PartnersLRVHealth+6 more

Concarloconcarlo.comin𝕏Mar 2017

Concarlo Therapeutics develops cancer therapeutics that target CDK4/6-driven cell proliferation and CDK2-driven resistance, focusing on improving outcomes for cancer patients through novel approaches in p27 biology.

BiotechBrooklyn, US

Stacy Blain(Founder, CEO)inLisaMarie Casey(President and Manager)

BoardJason Mraz(Executive Board Member)in

Co-investorsBioAdvanceCreative Destruction Lab (CDL)Raptor Group

Deep Echodeepecho.ioin

DeepEcho develops AI-powered intelligent ultrasound technology to detect birth defects, preterm birth, and low birth weight in newborns.

AI & Machine LearningDigital HealthFemTechHealthtechMedical Devices

Youssef Bouyakhf(Founder)in

Co-investorsAsia Africa Investment & Consulting (AAIC)UM6P VenturesAlgebra Ventures

EpiBoneepibone.comin𝕏

EpiBone engineers bone tissue from stem cells for regenerative medicine and clinical reconstruction, serving patients requiring bone grafts or craniofacial repair.

BiotechHealthtechMedical DevicesNew York, US

Nina Tandon(Co-Founder, CEO)inSarindr Bhumiratana(Co-Founder)inGordana Vunjak-Novakovic(Director)Elma Hawkins(Director)

BoardRobert Langer(Director)David Zhu(Director)in

Co-investorsBeresford VenturesEMV CapitalHackensack Meridian Health Bear's DenKendall Capital PartnersLifespan Vision VenturesMEDA Angels+3 more

Life Science Innovation Award 2022fiercelifesciences.com

Fierce Life Sciences provides news, analysis, and event education for the biopharma and life sciences industry, covering stages from preclinical research through market.

BiotechMedia & Entertainment

LunaJoy Healthhellolunajoy.comin𝕏

LunaJoy is a mental health platform that connects women facing postpartum challenges with mental health providers.

Digital HealthFemTechHealthtechMental HealthAtlanta, US

Sipra Laddha(Founder)inShama Rathi(Founder)inLiana Felt(Recruiting)Nathalie Alcala(Recruiter)Jill Chami(HR Director)Carrers LunaJoy(Recruiter)

Co-investorsAwareness VentureEmmeline VenturesFoundersX VenturesK20 FundNurture Venture PartnersVentureSouq+8 more

Madison Scientificmadsci.comin

Chicago-based medical device company developing the SmartShunt smart electromechanical shunt system for hydrocephalus.

HealthtechChicago, US

Tyler Wanke(Executive Officer, Director)inBermans Iskandar(Director)Joshua Medow(Executive Officer, Director)

BoardJoshua Carson(Director)inJohn Slump(Director)

Co-investorsIllinois VenturesmHUBEndeavor Health Ventures

Nua Surgicalnuasurgical.comin𝕏

NUA Surgical develops surgical medical devices focused on maternal and infant health, currently in pre-clinical development.

FemTechHealthtechMedical DevicesGalway, IE

Barry(CEO & Founder)inMarie Therese(COO & Co-Founder)inPadraig(CTO & Co-Founder)

Co-investorsTMC Venture FundEnterprise IrelandEQT Life Sciences

OffGridBoxoffgridbox.comin𝕏

OffGridBox provides integrated systems combining renewable energy generation and water purification for households and institutions such as health clinics and schools, including in humanitarian settings like refugee camps.

CleantechClimate TechEnergyFintechSomerville, US

Emiliano Cecchini(Co-founder & CTO)inDavide Bonsignore(Co-founder & Global Director)inBas Berends(Chief Executive Officer)in

BoardJodie Wu(Board Chair)

Co-investorsTechstars

OtoNexusotonexus.comin

OtoNexus Medical Technologies is developing an ultrasound-based otoscope (Novoscope) that uses a miniaturized sensor in a single-use ear speculum tip to give clinicians objective, point-of-care data on middle-ear fluid and infection type.

AI & Machine LearningDigital HealthHardwareHealthtechMedical DevicesSeattle, US

Caitlin Cameron(Chair & CEO)in

Co-investorsGolden SeedsDellin InvestmentsFarvatn VentureKeiretsu ForumMindshift CapitalPlanet 9 Capital+5 more

Pocket Naloxonepocketnaloxone.com

BiotechBethesda, US

Andrea Barthwell(Director)Behshad Sheldon(Director)Ashanthi Mathai(Executive Officer, Director)Serena Kim(Executive Officer)Kathryn Bowsher(Director)

Co-investorsKern Venture GroupMedMountain VenturesStartX

Sana Biotechnologysana.comin

Sana is a biotech company developing engineered cell medicines, including gene therapies for gene modification and delivery, cell replacement therapies using stem cell biology, and manufacturing solutions to improve patient access to these treatments.

BiotechHealthtechMedical DevicesSeattle, US

Richard Mulligan(Director)inHans Bishop(Founder)Steve Harr(Founder)James J. MacDonald(Executive Officer)Nathan Hardy(Executive Officer)

BoardGeoffrey von Maltzahn(Director)in

Co-investorsAmerican Family VenturesARCH Venture PartnersF-Prime CapitalFlagship PioneeringGV (Google Ventures)Innovating Capital+8 more

Sonavi Labssonavilabs.com

Baltimore, US

Ellington West(Executive Officer, Director, Promoter)Ian McLane(Executive Officer, Director)Jaishree McLane(Executive Officer, Director, Promoter)Brandon Dottin-Haley(Executive Officer, Director, Promoter)

BoardIlene Busch-Vishniac(Executive Officer, Director, Promoter)Leslie Wise(Director)

Co-investorsSand Hill Angels

Stingraytxstingraytx.comin

Stingray is an oncology-focused biotech company developing drugs from discovery through clinical development to commercialization, led by scientists and physicians with experience in building oncology companies.

AI & Machine LearningBiotechHealthtechHouston, US

Jonathan Northrup(Chief Executive Officer, Co-Founder)inSunil Sharma(Chief Medical Officer, Co-Founder)inScott Andrew Jordan(Executive Officer, Director, Promoter)

Co-investorsGreen Park & Golf Ventures

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

AlioAltoAOAAOA DiagnosticsAtai BeckleyAZTherapiesBicaraCeretypeCulturintelDeck TherapeuticsDionysusEgalEgal PadsEpiVaxFeminaiFlourishGeneiusLimaxLyndraMassiveBioMelioMicrobionNeuraxisNeuroRXOCONOncoheroesOrigamiPisonPyramesRaydiantRejuvenationSIAStarlightStemonixTerranTriajTvardiWavelyXtherma

Portfolio news

latest coverage across their companies

Frequently asked questions

How many investments has Catalytic Impact Foundation made?
Catalytic Impact Foundation has 57 tracked investments, including 1 dated in the last 24 months.
What stage does Catalytic Impact Foundation invest at?
Catalytic Impact Foundation invests at the Pre-Seed, Seed, Series A stages.
What sectors does Catalytic Impact Foundation focus on?
Catalytic Impact Foundation focuses on Biotech, Digital Health, FemTech, Healthtech, Impact & Social Good, Longevity, Medical Devices, Mental Health.
Where is Catalytic Impact Foundation located?
Catalytic Impact Foundation is headquartered in Hingham, US.
Who does Catalytic Impact Foundation co-invest with?
Catalytic Impact Foundation most often shares deals with Sand Hill Angels, Andreessen Horowitz, Battery Ventures, among 95 tracked co-investors.

Media · Podcasts & interviews

featuring the team

Rachel Butler, President, Catalytic Impact|TBCY

The Brand Called You · Rachel Butler

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