MRL Ventures Fund — Full Portfolio

Alector develops therapies targeting neurodegenerative diseases including Alzheimer's, frontotemporal dementia, and Parkinson's disease through protein removal, replacement, and immune cell restoration.

AI & Machine LearningBiotechHealthtechLongevityMedical DevicesSan Francisco, US

ARArnon Rosenthal(Ph.D.)inTGTillman Gerngross(Director)

BoardCarl Gordon(Director)TMTerry McGuire(Director)in

Co-investorsFOForesite CapitalGVGV (Google Ventures)MIMission Bay CapitalMIMission BiocapitalSVSV Health InvestorsPOPolaris Partners

Entrada Therapeutics is a biotech company developing intracellular therapeutics based on its proprietary EEV Platform, aimed at reaching previously inaccessible or undruggable disease-causing targets inside cells.

BiotechHealthtechBoston, US

NSNatarajan Sethuraman(Executive Officer)inNKNerissa Kreher(Executive Officer)inKWKory Wentworth(Executive Officer)inDDDipal Doshi(Chief Executive Officer)inNatarajan Sethuraman, PhD(President of Research and Development)NJNathan J. Dowden(President and Chief Operating Officer)in

Co-investors5A5AM VenturesAGAgent CapitalMPMPM BioImpactRORoche Venture FundTCTCG CrossoverWEWellington Management

Invivyd is a biopharmaceutical company that develops antibody-based product candidates for the prevention and treatment of serious viral infectious diseases, combining viral surveillance and predictive modeling with antibody engineering.

BiotechHealthtech

MEMarc Elia(Founder)in

Co-investorsBABain Capital Life SciencesFOForesite CapitalPRPremji InvestRARA CapitalGVGV (Google Ventures)MIMithril Capital Management+2 more

Kymera is a clinical-stage biotechnology company developing novel medicines using targeted protein degradation technology to treat diseases caused by previously "undrugged" proteins.

BiotechDeep TechHealthtech

NMNello Mainolfi(Founder)inBBBruce Booth(Chair)in

Co-investorsATAtlas VentureAVAvoro Capital AdvisorsBABain Capital Life SciencesBEBessemer Venture PartnersHAHatteras Venture PartnersNENextech Invest+7 more

Spero Therapeutics is a clinical-stage biopharmaceutical company developing medicines for immune-mediated diseases, led by SP001, a third-generation anti-CD40L antibody targeting IgG4-related disease.

BiotechCambridge, US

AMAnkit Mahadevia(Executive Officer, Director)inSGStephen Garbacz(Executive Officer)inEsther Rajavelu(Director, President, Chief Executive Officer, Chief Financial Officer, Chief Business Officer and Treasurer)in

BoardJFJean-Francois Formela(Director)inReza Halse(Director)Casper Breum(Director)

Co-investorsGVGV (Google Ventures)HEHEALTHCARE ROYALTY PARTNERSOUOUP (Osage University Partners)RARA CapitalALAlphabetATAtlas Venture+1 more

Xilio Therapeutics is a clinical-stage biotechnology company developing masked immuno-oncology therapies that use protein engineering to remain inactive until activated by tumor-specific proteases within the tumor microenvironment.

BiotechHealthtechWaltham, US

RRRené Russo(Executive Officer, Director)inJoseph Farmer(Executive Officer)Timothy Clackson(Executive Officer)Christopher Frankenfield(Chief Financial and Operating Officer)inKLKatarina Luptakova(Chief Medical Officer)inPaul Clancy(Director)

Co-investorsBABain Capital Life SciencesBABay City CapitalF-F-Prime CapitalM M VenturesRARA CapitalRIRiverVest Venture Partners+9 more

ATB Therapeutics is a biotech company developing bispecific antibody therapies and related immunological treatments.

BiotechHealthtechMedical Devices

DMDr. Mark Throsby(Chief Executive Officer)

Co-investorsV-V-Bio VenturesVIVIVES PartnersEQEQT Life SciencesSASambrinvestWAWallonie EntreprendreEQEQT

Axonis Therapeutics is a biotechnology company developing small-molecule medicines that target KCC2, a mediator of inhibition in the brain, to treat neurological disorders such as epilepsy and pain.

BiotechDeep TechBoston, US

SVShane V. Hegarty(Chief Scientific Officer & Co-Founder)inJSJoanna Stanicka(Chief Executive Officer, President & Co-Founder)inJIJeff Imbaro(Chief Operating Officer)inTSTiasha Shafiq(Chief of Staff)in

BoardC.Corey . Goodman(Director)inJLJonathan Leff(Director)in

Co-investorsSOSofinnova VenturesVEvenBio PartnersCICivilization Ventures Management, LlcCRCreative Destruction Lab (CDL)HAHatteras Venture PartnersIAIaso Ventures+8 more

InduPro develops next-generation protein therapeutics by leveraging inherent and induced proximity to modulate disease biology, with a focus on ADCs and T-cell engagers.

BiotechDeep TechMedical DevicesSeattle, US

KCK. Chris Garcia(Scientific Founder)PRPrakash Raman(CEO)inAJAmanda J. Redig(Chief Medical Officer)inSLScott Lesley(President & CSO)inPHPamela Holland(SVP of Biology)inSJSally Johnson(Chief People Officer)in

Co-investorsTHThe Column GroupVIVida Ventures

Photys Therapeutics develops bifunctional small-molecule medicines that use induced proximity to recruit kinases and drive targeted protein phosphorylation, aiming to modulate and repair disease-driving proteins.

BiotechHealthtechLongevityWaltham, US

Amit Choudhary(Scientific Founder)DSDavid Steinberg(Chairman & Founding CEO)inEHEdward Holson(Co-founder & CSO)inLNLizzie Ngo(Co-founder)inBrian Fenton(President & CEO)in

Co-investorsLOLongwood FundMPMPM BioImpact8V8VCONOno Venture Investment, Inc.

Therini Bio is a biotechnology company developing fibrin-targeting therapeutics to treat neurological and ophthalmological diseases, leveraging scientific discoveries in neurovascular and neuroimmune mechanisms of disease.

BiotechDigital HealthHealthtechMedical DevicesSacramento, US

KAKaterina Akassoglou(Scientific Founder, Director of the Center for Neurovascular Brain Immunology and Professor of Neurology at UCSF and Gladstone Institutes)inKAKaterina Akassoglou, PhD(Scientific Founder)LSLeslie Schulze(Executive Officer)TNTara Nickerson(Executive Officer, Director)in

BoardODOlga Danilchanka(Director)inLaia Crespo-Martin(Director)

Co-investorsSASanofi VenturesSVSV Health InvestorsANAngelini VenturesDEDementia Discovery FundDODolby Family VenturesMIMitsui Global Investment+2 more

Topo Therapeutics is a drug discovery company developing treatments targeting ion channels and transmembrane proteins for conditions such as pain, epilepsy, and CNS, pulmonary, and renal diseases.

BiotechHealthtechCambridge, US

HTHui Tian(Executive Officer, Director)inMadgalene Moran(Executive Officer, Director)MMMagdalene Moran(Chief Executive Officer)

BoardBruce Bean(Director)James Jeffrey Goater, Jr.(Director)

Board seatKKKarin Kleinhans· per SEC Form D

Co-investorsSRSR One Capital ManagementTHThe Column Group

Ambagon develops small molecule stabilizers of 14-3-3 protein complexes to modulate disease-related protein interactions, targeting therapeutic areas including cancer, metabolic disorders, neurodegenerative and infectious diseases.

BiotechDeep TechMedical DevicesEindhoven, US

COChristian Ottmann(Executive Officer)inJosh Seidenfeld(Executive Officer)Michelle Arkin(Director)Nancy Pryer(Executive Officer)Margarita Chavez(Director)Bryan Miller(Executive Officer)

Co-investorsDRDroia VenturesINInkefMIMission BiocapitalNENextech InvestRARA Capital

Caraway Therapeutics was a preclinical biopharmaceutical company developing small-molecule therapies modulating lysosomal function to treat neurodegenerative and rare diseases.

BiotechHealthtech

Co-investorsDEDementia Discovery FundEIEisai Innovation, Inc.MCMcCarthy CapitalSVSV Health InvestorsABAbbVieBRBridge Investments+9 more

CAR-Macrophage cellular therapeutics with initial oncology focus (NASDAQ: CARM).

BiotechPhiladelphia, US

SKSteven Kelly(Executive Officer, Director)in

BoardMargarita Chavez(Director)inEran Nadav(Director)Althea Stillman(Director)Jacob Gunterberg(Director)RHRegina Hodits(Director)in

Co-investorsAGAgent CapitalAJAju IB InvestmentANAnzu PartnersGRGrazia Equity GmbHHEHealthCapSOSolasta Ventures+3 more

HotSpot Therapeutics develops novel biopharmaceutical products and therapeutic platforms focused on innovative biomedical technologies.

AI & Machine LearningBiotechHealthtech

BoardBBBruce Booth(Chairman)in

Co-investorsATAtlas VentureB B Capital GroupB4B4 CapitalPIPivotal Life SciencesSOSofinnova PartnersSOSolasta Ventures+2 more

A pharmaceutical company that develops medicines and vaccines, with research pipelines and clinical trials aimed at new treatments.

BiotechHealthtech

Co-investorsFRFrazier Life SciencesHIHighlight CapitalXEXeraya CapitalAMAmgen VenturesBLBlackRockBLBlackstone Life Sciences+5 more

Insamo develops an automated platform for drug discovery that designs, synthesizes, and tests cyclic peptides at scale using machine learning and proprietary experimental data.

AI & Machine LearningBiotechDeep TechChippendale, AU

TCTim Craven(CEO)inTPToby Passioura(Founder)inGlen McIntyre(Founder)Timothy Craven(Founder)

BoardCGCOREY GOODMAN(Director)inMHMATT HERSHENSON(Director)in

Co-investorsBEBEVCCICivilization Ventures Management, LlcPLPlayground GlobalVEvenBio PartnersAXAxial VCVEvenBio Global Strategic

Kymera International manufactures specialty materials and surface technologies, including metal powders, alloys, and advanced coatings, serving industrial customers across aerospace, automotive, electronics, and other sectors globally.

Advanced ManufacturingDeep TechNew MaterialsDetroit, US

Willson Ropp(Chief Executive Officer)in

Co-investorsPLPlatinumPAPalladium

LAVA develops the Gammabody platform, which generates bispecific antibodies that activate gamma-delta T cells to treat cancer by directing immune cells to tumors and triggering anti-cancer immune responses.

AI & Machine LearningBiotechHealthtechMedical Devices

Ton AdanginHVHans van der Vliet(Head of Innovation)inSHSteve Hurly(Chief Executive Officer)OPOxana Polyakova(Chief Scientific Officer)in

Co-investorsSASanofi VenturesYSYsios CapitalGIGilde HealthcareNONovo HoldingsREREDMILE

LifeMine is a biopharmaceutical company that uses data science and advanced methods to accelerate drug discovery and develop precision medicines across therapeutic areas.

AI & Machine LearningBiotechDeep TechCambridge, US

GLGregory L. Verdine(Executive Officer, Director)GVGregory Verdine, Ph.D.

BoardHingge Hsu(Executive Officer, Director)Weiqing Zhou(Executive Officer, Director)

Co-investorsARARCH Venture PartnersGVGV (Google Ventures)RARA CapitalAIAisling CapitalALAlexandriaBEBezos Expeditions+7 more

Mozart Therapeutics develops protein therapeutics focused on immunology and oncology treatments.

BiotechMedical Devices

MDMark Davis(Scientific Co-Founder)K. Christopher Garcia(Scientific Co-Founder)CKCalvin Kuo(Scientific Co-Founder)KFKatie Fanning(President & Chief Executive Officer)in

Co-investorsARARCH Venture PartnersJDJDRF T1D FundONOno Venture Investment, Inc.PFPfizer Venture InvestmentsSOSofinnova PartnersABAbbVie+6 more

MSD is a pharmaceutical company focused on developing medicines and vaccines for patients globally, guided by a science-led innovation strategy.

BiotechHealthtechMedical Devices

Myoventive develops RNA-based medicines to treat genetic heart diseases.

BiotechSouth San Francisco, US

Co-investorsVEvenBio Partners

Developing novel KRAS degraders.

Burlington, US

Huaixiang Hao(Founder)in

Co-investorsBIBioTrack CapitalJJJJDC

Teambit analyzes code, meeting time, and interactions to measure and improve the performance of software development teams, delivering objective metrics.

AI & Machine LearningDeveloper ToolsSaaS

PEPaula Enei(Founder)in

Co-investorsGGGG Capital4B4BIO CapitalDEDeerfield Management CompanyGEGeneral CatalystNONorwest Venture PartnersNONovo Holdings

Tallac Therapeutics is a clinical-stage biopharmaceutical company developing oligonucleotide-based antibody conjugates (TRAAC candidates) designed to deliver immune-activating agents to tumor microenvironments for oncology indications.

BiotechHealthtechMedical DevicesBurlingame, US

HWHong Wan(Executive Officer, Director)in

BoardRan Geng(Director)Michael Carusi(Director)Isaac Cheng(Director)Christine Brennan(Director)CGCorey Goodman(Director)in

Co-investorsLILightstone VenturesVEvenBio PartnersMAMatrix Partners ChinaVEvenBio Global Strategic

Sanofi is an R&D-driven, AI-powered biopharmaceutical company that develops medicines and vaccines, with a focus on immunology and the immune system.

AI & Machine LearningBiotechHealthtech

Co-investorsNENew Enterprise Associates (NEA)RHRho VenturesSASanofi VenturesFJFJ Labs

Viridian Therapeutics develops treatments for thyroid eye disease, a rare autoimmune condition affecting the eyes and orbit.

BiotechDigital HealthMedical DevicesWaltham, US

JVJonathan Violin(Executive Officer, Director)in

BoardPeter Harwin(Director)Tomas Kiselak(Director)

Co-investorsBRBroadview VenturesLOLongitude Capital

A biologics center of excellence focused on developing and delivering medicines to patients, operating as a subsidiary within the Otsuka pharmaceutical group.

AI & Machine LearningBiotechHealthtechMedical Devices

Zachary Shriver(President and Chief Executive Officer)KVKarthik Viswanathan(Vice President, Research)in

Co-investorsCTCTI Life Sciences Fund L.P.CYCycad Group LLCLULux Capital