RiverVest Venture Partners — Full Portfolio

Avalyn Pharma develops inhaled therapies for pulmonary fibrosis, using a nebulization approach that delivers treatment directly to the lungs to reduce the tolerability problems of existing oral therapies.

BiotechHealthtech

LBLyn Baranowski(CEO)in

Co-investorsANAndera PartnersCACatalio Capital Management, LPF-F-Prime CapitalINInVivium CapitalNONorwest Venture PartnersPIPivotal Life Sciences+9 more

MacroGenics is a clinical-stage biopharmaceutical company developing antibody-based therapies for cancer patients.

BiotechHealthtechMedical Devices

Scott Koenig(Director)inEREric Risser(President and Chief Executive Officer)in

Co-investorsHAHavencrest Capital ManagementRIRidgeback CapitalSASaints CapitalSASanofi VenturesLALa CaisseTPTPG

Mirum Pharmaceuticals is a biopharmaceutical company that develops and delivers therapies for people living with rare diseases.

BiotechHealthtechSan Diego, US

CPChris Peetz(Co-founder & Chief Executive Officer)inEBEric Bjerkholt(Executive Officer)inPRPeter Radovich(Executive Officer)in

BoardPHPatrick Heron(Director)inMichael Grey(Director)Timothy Walbert(Director)

Co-investorsCHChiesi VenturesFRFrazier Life SciencesLOLongitude CapitalMEMESA VERDE VENTURE PARTNERSNENew Enterprise Associates (NEA)PAPappas Capital+4 more

OnKure Therapeutics is a clinical-stage biopharmaceutical company developing PI3Kα pan-mutant selective inhibitor medicines for the treatment of breast cancer and vascular anomalies.

BiotechDigital HealthHealthtechMedical DevicesBoulder, US

JLJason Leverone(Executive Officer)inSASamuel Agresta(Executive Officer)inDHDylan Hartley(Executive Officer)inWendy Johnson(Executive Officer)Nicholas A. Saccomano(President and Chief Executive Officer and Director)

BoardIMIsaac Manke(Director)in

Co-investorsACAccess BiotechnologyBOBoulder VenturesABAbingworthACACORN BIOVENTURESNENew Enterprise Associates (NEA)NONovo Holdings

Xilio Therapeutics is a clinical-stage biotechnology company developing masked immuno-oncology therapies that use protein engineering to remain inactive until activated by tumor-specific proteases within the tumor microenvironment.

BiotechHealthtechWaltham, US

RRRené Russo(Executive Officer, Director)inJoseph Farmer(Executive Officer)Timothy Clackson(Executive Officer)Christopher Frankenfield(Chief Financial and Operating Officer)inKLKatarina Luptakova(Chief Medical Officer)inPaul Clancy(Director)

Co-investorsBABain Capital Life SciencesBABay City CapitalF-F-Prime CapitalM M VenturesMRMRL Ventures FundRARA Capital+9 more

Biolinq develops glucose-sensing technology based on micro-array biosensors for metabolic health monitoring, including continuous glucose monitoring.

BiotechDigital HealthHardwareHealthtechMedical DevicesSan Diego, US

JTJared Tangney(Co-founder)inRYRich Yang(Co-founder)inEdward Kliphuis(Director)

BoardDBDaniel Bradbury(Director)inLGLana Ghanem(Director)

Co-investorsALAlpha Wave GlobalABAble PartnersAPAphelion CapitalAVAverin CapitalBEBeyond CapitalBIBioBrit+7 more

Engrail Therapeutics is a clinical-stage pharmaceutical company developing precision-targeted therapeutics for neupropsychiatric and neurodevelopmental disorders.

BiotechDigital HealthMedical DevicesSan Diego, US

Stephen(Co-founder, EVP Research & Development and Chief Development Officer)Paul Cayer(Chief Financial Officer)inVikram(President and Chief Executive Officer)Kimberly(Chief Scientific Officer)Quentin(Chief Technical Officer)

Co-investorsFOForesite CapitalLOLongwood FundNONorwest Venture PartnersPIPivotal Life SciencesYSYsios CapitalABabrdn plc+4 more

Alleviant Medical develops an investigational minimally invasive medical device using interatrial shunt therapy to treat heart failure patients, currently in FDA-approved clinical trials (ALLAY-HF and ALLAY-HFrEF).

BiotechHealthtechMedical DevicesAustin, US

Adam Berman(Executive Officer, Director)inJacob Kriegel(Executive Officer, Director)Avni Patel(Executive Officer, Director)Christopher Alex Arevalos(Executive Officer, Director)Albertien Greijdanus(Executive Officer, Director)

BoardGPGeoff Pardo(Director)in

Board seatJSJay Schmelter· per SEC Form D

Co-investorsBRBroadview VenturesTMTMC Venture FundCACadence Healthcare VenturesGIGilde HealthcareGIGilmartin Capital LLCOMOmega Funds+2 more

Bonum Therapeutics develops antibody-controlled protein therapeutics that remain inactive until bound to their target, using a sensor-domain mechanism to deliver regulated, targeted activity.

BiotechHealthtechSeattle, US

JMJohn Mulligan(Executive Officer, Director, Promoter)inNPNeela Patel(Executive Officer)inDHDiane Hollenbaugh(Executive Officer)in

BoardSBSamuel Bjork(Director)inMSMonique Schiersing(Director)in

Board seatJMJohn McKearn· per SEC Form D

Co-investorsRORoche Venture FundVIVivo Capital3X3x5 PartnersCOCodon CapitalDIDigitalis Ventures

Developing implantable low-energy pain-free atrial cardioverters for atrial fibrillation.

HealthtechSt. Louis, US

M. Brent Shelton(Executive Officer)Paula Skjefte(Executive Officer, Director)Nick Lanners(Executive Officer)Igor Efimov(Director)

BoardEric A. Gulve(Executive Officer, Director)Warren Watson(Director)

Board seatJSJay Schmelter· per SEC Form D

Co-investorsBRBroadview VenturesCUCultivation Capital

Avalyn Pharma (formerly Genoa Pharmaceuticals) is a biopharma company developing inhaled therapies for idiopathic pulmonary fibrosis (IPF) and other severe respiratory diseases.

BiotechHealthtechSan Diego, US

Mark W. Surber, Ph.D.(Executive Officer, Director)Richard G. Vincent(Executive Officer)

BoardMichael J. Kamdar(Director)Daniel D. Burgess(Director)

Board seatNONiall O'Donnell· per SEC Form D

Co-investorsF-F-Prime CapitalNONorwest Venture PartnersSOSofinnova Ventures

Portfolio company acquired by Roche.

BiotechSeattle, US

JMJohn Mulligan(Executive Officer, Director, Promoter)inMitchell Mutz(Director)Nicholas Walrod(Director)

BoardKarl Handelsman(Director)

Board seatJMJohn McKearn· per SEC Form D

Co-investorsDIDigitalis VenturesRORoche Venture Fund3X3x5 PartnersCOCodon Capital

InterVene, Inc. is a medical device company that has developed a fully integrated mechanical thrombectomy system to treat venous in-stent restenosis and residual thrombotic venous obstructions and occlusions.

BiotechHealthtechMedical DevicesMountain View, US

Fletcher Wilson(Executive Officer, Director)in

BoardTFThomas Fogarty(Director)Mel Schatz(Director)

Board seatJSJay Schmelter· per SEC Form D

Co-investorsLALaunchCapitalTRTreo Ventures, LlcEMEmergent Medical Partners, LLP

Clinical-stage immuno-oncology company developing antibodies derived from the immune systems of 'Elite' cancer responders.

BiotechHouston, US

ABAlice Bexon(Executive Officer)inCJClifford J. Stocks(Director, Executive Officer)inKDKamal D. Puri(Executive Officer)inCRChris Russell(Executive Officer)inRuss Hawkinson(Executive Officer)

BoardSGSteven Gillis(Director)in

Board seatJMJohn McKearn· per SEC Form D

Co-investors3B3B Future Health FundCACanaan PartnersGRGreatPoint VenturesALAlexandriaARARCH Venture PartnersBEBering Capital+5 more

Smart Wires provides advanced power flow control technology for electric utilities and transmission operators, letting them redirect electricity away from constrained circuits to increase usable transfer capacity and strengthen grid reliability.

CleantechEnergyHardwareOakland, US

James C David(Executive Officer, Director)Woody Gibson(Executive Officer)Stewart Ramsay(Executive Officer, Director)

BoardAnthony Arnerich(Director)Frederick Buckman(Director)

Board seatJSJay Schmelter· per SEC Form D · $85.8M raise · filed Jan 2020

Co-investorsALAlumni VenturesENEnergy Transition Ventures3X3x5 Partners

Sparrow Pharmaceuticals is a clinical-stage biopharmaceutical company developing targeted therapies for cardiometabolic disease.

BiotechHealthtechMedical DevicesPortland, US

RJRobert Jacks(Executive Officer, Director)inDavid Aaron Katz(Executive Officer, Director)

BoardJRJonathan Root(Director)inZSZach Scheiner(Director)inKVKlaus Veitinger(Director)in

Board seatNONiall O'Donnell· per SEC Form D

Co-investorsOROrbiMedRARA CapitalUSUS Venture PartnersFOForbion

Allotera (formerly Wugen) develops allogeneic T-cell therapies.

BiotechHealthtechMedical DevicesSt. Louis, US

AKAyman Kabakibi(Executive Officer)inCherry Thomas(Executive Officer)inKSKumar Srinivasan(Executive Officer, Director)inKeith Vendola(Executive Officer)Daniel M Kemp(Executive Officer, Director)Matthew Cooper(Executive Officer)

Board seatNONiall O'DonnellJMJohn McKearn· per SEC Form D

Co-investorsAIAisling CapitalALAlpha Wave GlobalBIBioGenerator VenturesABAbingworthFIFidelity InvestmentsINIntermediate Capital Group+1 more

Portfolio company that completed a successful 2018 biotech IPO, resulting in a 9x return for RiverVest.

BiotechSan Carlos, US

Nenad Tomasevic(Executive Officer)Christopher Bebbington(Executive Officer, Director)Alejandro Dorenbaum(Executive Officer)

BoardFCFarah Champsi(Director)inJMJohn McKearn(Director)inPeter Moldt(Director)

Co-investorsALAlta PartnersLILifeSci Venture PartnersNENew Enterprise Associates (NEA)RORoche Venture FundSASamsara BioCapital

St. Louis, US

Co-investorsAIAisling CapitalBIBioGenerator VenturesLYLYZZ CapitalABAbingworth

Developing a new class of antifungal medicine to overcome limitations of current therapies.

Co-investorsBIBioBritGOGolden SeedsKEKeiretsu ForumPAPappas CapitalSOSofinnova Ventures3X3x5 Partners+4 more

Pfizer discovers, develops, manufactures, and distributes pharmaceutical medicines and vaccines across therapeutic areas including oncology, cardiology, immunology, and infectious diseases.

BiotechHealthtechMedical DevicesNew York, US

Charles Pfizer

Co-investorsAIAisling CapitalANAndera PartnersRHRho Capital PartnersRHRho VenturesVEVenrockNENew Enterprise Associates (NEA)

AnTolRx develops immunotherapy therapeutics based on research in immune tolerance, targeting immune-mediated disorders.

BiotechHealthtechBoston, US

Francisco J. Quintana(Scientific Founder, Member of Board of Directors)MCMark Carthy(Founder and CEO, Member of Board of Directors)

BoardSatish Jindal(Director)

Co-investorsAVAvego BioScience CapitalBIBioGenerator VenturesPEPerot JainRORoche Venture FundSRSR One Capital Management

Arexera Therapeutics, formerly Atalanta Therapeutics, is a biotechnology company developing small interfering RNA (siRNA) medicines to treat severe neurological diseases, with a franchise focused on Huntington's disease.

BiotechLongevity

Atalanta is developing treatment options for intractable central nervous system diseases using RNA interference technology.

BiotechDeep TechHealthtechMedical Devices

Co-investorsF-F-Prime CapitalNONovartis Venture FundSASanofi VenturesABabrdn plcEQEQT Life Sciences

Biogen is a biotechnology company founded in 1978 that focuses on breakthroughs in biology.

BiotechMedical Devices

Charles Weissmann(Founder)Kenneth Murray(Founder)Phillip Sharp(Founder)Walter Gilbert(Founder)

Co-investorsALAlpha Wave GlobalASAsset Management CompanyKLKleiner Perkins

Bluejay develops tools for improving the reliability of generative AI systems in production environments.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US

RVRohan Vasishth(CEO)inFSFaraz Siddiqi(CTO)in

Co-investorsANAntigravity CapitalEIEight CapitalFLFloodgateHOHomebrewMOMoonlanding VenturesY Y Combinator+6 more

Bluejay is a biotechnology company focused on therapeutic development.

BiotechSan Mateo, US

KCKeting Chu(Founder, Chief Executive Officer and Chairman of the Board)inDajun Yang(Director)Nancy Hong(Director)inAlon Lazarus(Director)William J. Rutter(Director)Ting Jia(Director)

Co-investorsFRFrazier Life SciencesRARA CapitalWEWellington ManagementFRFrazier Healthcare PartnersHBHBM Healthcare InvestmentsNONovo Holdings+2 more

Lifepoint is a diversified healthcare delivery network operating community hospitals, rehabilitation and behavioral health hospitals, and additional sites of care across the healthcare continuum.

Digital HealthHealthtech

Scott Mercy(Founding Chairman and CEO)

Co-investorsBABaird CapitalRCRC Capital

Gilead discovers, develops, and delivers innovative therapeutics for people with life-threatening diseases, focusing on virology, oncology, and inflammation across more than 35 countries.

BiotechDigital HealthHealthtechMedical DevicesFoster City, US

LLLou Lange(Founder)MLMichael L. Riordan(Founder)inDODaniel O'Dayin

Co-investorsAIAisling CapitalASAsset Management CompanyFRFrazier Life SciencesKLKleiner PerkinsLOLongitude CapitalLULumira Ventures+6 more

Captisol is a pharmaceutical-grade sulfobutylether beta-cyclodextrin (SBECD), a derivatized beta cyclodextrin used to solubilize and stabilize difficult-to-deliver molecules across routes such as parenteral, oral, ophthalmic, nasal, and inhalation.

BiotechHealthtechNew Materials

Medtronic designs and develops medical technology for treating complex diseases.

AI & Machine LearningDigital HealthHealthtechMedical Devices

Co-investors8V8VCCWCWRU Technology VenturesELElevate VenturesMEMenlo VenturesOAOak Investment PartnersPFPfizer Venture Investments+5 more

FLEX Vascular develops endovascular devices for treating stenoses in arteriovenous fistulas, grafts, and peripheral vascular conditions.

BiotechHealthtechMedical Devices

John P. Pigott(Founder, Advisor)John P. Pigott, MD(Founder, Advisor)

Co-investorsS3S3 Ventures

Bristol Myers Squibb is a biopharmaceutical company that develops and delivers medicines across oncology, hematology, neuroscience, immunology, and cardiovascular disease areas.

BiotechHealthtechMedical DevicesNew York, US

Co-investorsBRBrandon CapitalKLKleiner PerkinsNENew Enterprise Associates (NEA)NENextech InvestPRProspect Venture PartnersRHRho Capital Partners+3 more

Glycomine develops therapeutics for rare diseases, many of which currently lack disease-modifying treatment options.

BiotechSan Francisco, US

Agnes Rafalko(Executive Officer, Director)inSASteven Axon(Chief Executive Officer)inHAHicham Alaoui(Chief Scientific Officer)inRMRose Marino(Chief Medical Officer)inPMPeter McWilliams(Chief Business Officer)GHGeoffrey Hird(Chief Technology Officer)in

Co-investorsADAdvent Life SciencesASAsahi Kasei Corporate Venture CapitalCHChiesi VenturesCTCTI Life Sciences Fund L.P.MIMission Bay CapitalMIMission Biocapital+6 more

Acquired by Shire in 2014 (now part of Takeda).

BiotechMedical DevicesDurham, US

John McKearn(Director)Edward E. Greene(Director)Rosina Maar Pavia(Director)Ford S. Worthy(Executive Officer)Michael Grey(Executive Officer, Director)

Co-investorsFRFrazier Life SciencesLOLongitude CapitalOBOberland CapitalPAPappas CapitalSASanofi Ventures

Maxwell Biomedical develops a device-based alternative to catheter ablation for atrial fibrillation, using closed-loop adaptive left atrial multisite pacing and Spatial Resynchronization Therapy (SRT) to terminate AF without high-energy shock.

BiotechHardwareHealthtechMedical Devices

RWRandy Werneth(CEO, President)inTimothy Corvi(Sr. VP, R&D)inDerrick Chou(VP, Science & Technology)

Co-investorsBRBroadview Ventures

Neuros Medical develops the Altius Direct Electrical Nerve Stimulation System, an FDA-approved implantable device that delivers patient-controlled electrical stimulation to treat chronic post-amputation pain in adult lower limb amputees.

BiotechHealthtechMedical DevicesAliso Viejo, US

David Veino(President and CEO)Zach Stassen(Chief Financial Officer)Robert J. Centa(Chief Financial Officer)JJJon J. Snyder(Director, President, Secretary and CEO)in

BoardJEJoyce Erony(Director)inWHWilliam Harrington(Director)in

Co-investorsAMAmzak HealthAPAPERTURE Venture PartnersCWCWRU Technology VenturesISiSelect FundJOJobsOhio VenturesJUJumpstart Ventures+5 more

Reneo is an asset and investment management platform for decarbonizing residential real estate portfolios in Germany.

Climate TechEnterprise SoftwarePropTechGermany, DE

LBLennart Börner(Founder & Co-CEO)inAGAlexander Graubner-Müller(Founder & Co-CEO)in

Co-investorsFOFoundamentalABAbingworthAIAisling CapitalAMAmzak HealthEUEurazeoLALakestar+4 more

Xoilac TV is a free online football (soccer) live-streaming platform serving fans in Vietnam, offering Full HD match broadcasts of European, Asian, Vietnamese, and international competitions.

ConsumerMedia & EntertainmentSports Tech

Co-investorsAIAisling CapitalNENew Enterprise Associates (NEA)PAPappas CapitalABAbingworthAMAmzak HealthLULundbeckfonden Ventures+2 more

Scout Bio developed biotechnology therapies for pets, including a pipeline of monoclonal antibodies and gene therapy programs targeting chronic diseases in companion animals.

AgTechBiotechDeep TechHealthtechPhiladelphia, US

MHMark Hefferman(Executive Officer, Director)

BoardAKAditya Kohli(Director)inTadataka Yamada(Director)PHPatrick Heron(Director)inCCCindy Cole(Director)inNancy Hong(Director)

Co-investorsCOCompanion FundCOCorrelation VenturesDIDigitalis VenturesFRFrazier Life Sciences

BiotechWaltham, US

Ellen E. Sheets(Executive Officer, Director)in

BoardCarl M. Berke(Director)inNancy Hong(Director)in

Co-investorsBOBold Capital PartnersDIDigitalis VenturesKDKdT Ventures

ShareFile provides secure file sharing, document collection, e-signature capabilities, and automated workflow management for teams collaborating with clients, partners, and vendors.

Enterprise SoftwareSaaS

Co-investorsASAstellaBLBlack Diamond VenturesBRBrightstone Venture CapitalCICID CapitalCOConcord Health PartnersH H Venture Partners+1 more

Standard Bariatrics develops the Titan SGS™ Stapler, a specialized surgical device designed for sleeve gastrectomy procedures that creates consistent and symmetrical gastric pouches using an anatomy-based approach.

Medical Devices

Co-investorsARArieal Southeast Angel PartnersCICincyTechEMEmergent Medical Partners, LLPHAHatteras Venture PartnersJOJobsOhio VenturesRCRC Capital+2 more

Statcounter provides website analytics and visitor tracking software that displays traffic data, user behavior, and engagement metrics in a simple interface.

AdTechData & InfrastructureMarketing TechSaaS

ACAodhán Cullen(Founder and CEO)in

Co-investorsGAGabriel Venture PartnersHOHomegrown CapitalHUHuangpu River CapitalIAIaso VenturesKUKumpulan Modal PerdanaNUNucleation Capital+2 more

WP Engine provides managed hosting and platform services for WordPress websites, serving companies and agencies of all sizes with infrastructure, tools, and support.

Cloud ComputingDeveloper ToolsEnterprise SoftwareSaaSAustin, US

JCJason Cohen(Founder)inDBDavid Brolsma(Executive Officer)inHBHeather Brunner(Executive Officer)inCCChad Costello(Executive Officer)inRick Crandall(Director)Mariano Dima(Director)

Co-investorsACAcario InnovationBOboldstart venturesCACapital FactoryEQEquity Trust CompanyGOGolub GrowthHAHazelview Ventures+9 more

BiotechCoppell, US

Alvaro F. Guillem(Executive Officer, Director)Todd Creech(Executive Officer)Donald Jeffrey Keyser(Executive Officer, Director)Cynthia Smith(Executive Officer)Henrick Sandvad Rasmussen(Executive Officer)Robert Alexander(Executive Officer, Director)

Co-investorsSOSofinnova Ventures