Flagship Pioneering — Full Portfolio

Seres Therapeutics is a clinical-stage biotechnology company developing therapies composed of rationally selected live bacterial consortia to treat serious diseases through modulation of the human microbiome.

BiotechDigital HealthHealthtechMedical DevicesCambridge, US

Matthew Henn(President and Chief Scientific Officer)in

Co-investorsRA CapitalSofinnova Ventures

BiotechCambridge, US

John Aunins(Executive Officer)Eric D. Shaff(Executive Officer)David Cook(Executive Officer)Roger J. Pomerantz(Executive Officer, Director)

Board seatDavid BerryNoubar Afeyan· per SEC Form D · $65M raise · filed Jan 2015

CIBO provides a software platform for designing, deploying, and measuring regenerative agriculture and conservation programs, including workflow automation, scientific modeling, impact reporting, and a network of advisors managing grower engagement.

AgTechAI & Machine LearningClimate TechSaaSCambridge, US

Bruno Basso(Co-Founder and Special Advisor)David Worn(Executive Officer, Director)inBarry Martin(Executive Officer)inRyan Richt(Executive Officer)inDale Sorensen(Executive Officer)Sunand Menon(Executive Chairman & CEO)in

Board seatIgnacio MartinezStephen BerensonNoubar Afeyan· per SEC Form D

Co-investorsGeneration Investment ManagementStage 1 Ventures

Abiologics uses computational design tools to create protein-inspired molecules called Synteins, engineered to avoid the vulnerabilities of natural protein medicines while retaining biological function.

AI & Machine LearningBiotechDeep Tech

Avak Kahvejian(Chairman (Founder / founding CEO))inMike(Chief Innovation Officer & Co-Founder)Jaclyn Dunphy(Co-Founder & Senior Director of Strategy and Research Operations)inMaria-Chiara Magnone(Chief Scientific Officer)in

Alltrna develops engineered, chemically modified tRNA oligonucleotides as programmable medicines, using proprietary machine learning tools to design tRNA molecules with desired pharmacologic properties.

AI & Machine LearningBiotechDeep TechHealthtech

Lovisa Afzelius(Executive Chair & Founding CEO)inMichelle Werner(CEO)inJoanne Protano(President & Chief Financial Officer)inDave Hava(Chief Scientific Officer)inNerissa Kreher(Chief Medical Officer)inCaroline Köhrer(SVP, Discovery Platform)in

Apriori Bio applies AI/ML combined with biological insights to predict how viruses evolve and to design vaccines, assessing their expected performance before clinical trials.

AI & Machine LearningBiotechDeep TechHealthtech

Cloud ComputingData & InfrastructureEnterprise SoftwareAustin, US

Jonathan Ring(Executive Officer, Director)Paul Carpentier(Director)George Teixeira(Chairman of the Board, Co-founder)inJohn Bocskor(Former DataCore Vice President, Product Development and Co-founder)inMark Goros(Executive Officer, Director)Dave Zabrowski(Chief Executive Officer)in

Co-investorsInsight PartnersNew Science Ventures

Etiome develops stage-specific medicines by applying single-cell omics and artificial intelligence to map disease progression and identify disease-modifying targets at early biological inflection points for preemptive intervention.

AI & Machine LearningBiotechLongevity

Katharine von Herrmann(Co-founder)inAvak Kahvejian(Founding Team; Founding CEO)inNoubar Afeyan(Founding Team)Scott Lipnick(Founding Team)inTorben Straight Nissen(Founding Team; Board Director)inYann Echelard(Founding Team; Chief Operating Officer)

Inari applies artificial intelligence and gene editing to accelerate plant breeding, delivering crop improvement solutions for farmers focused on soybeans, corn, and wheat across broadacre agriculture.

AgTechAI & Machine LearningBiotechCambridge, US

Lisa Safarian(CEO)inStuart Brown(Chief Financial Officer)Pierre-Etienne Boin(Secretary and General Counsel)inPonsi Trivisvavet(President and Chief Executive Officer)in

BoardRobert Berendes, Ph.D.(Director)Ignacio Martinez(Director)in

Co-investorsAcre Venture PartnersCongruent VenturesG Squared

DataCore develops software-defined storage and object storage solutions for enterprises to virtualize and manage storage infrastructure across primary, secondary, and archive environments.

Cloud ComputingData & InfrastructureEnterprise Software

George Teixeira(Chairman of the Board, Co-founder)inJohn Bocskor(Co-founder, Former Vice President of Product Development)in

Co-investorsInsight PartnersPartners for GrowthPartners for Growth (PFG)Utiliti GroupAME Cloud Ventures

Metaphore develops a platform that measures biological activity inside cells at scale to design antibody medicines with novel mechanisms of action.

AI & Machine LearningBiotechDeep TechMedical Devices

Co-investorsGlobal Brain

Montai is a drug discovery company that combines human biology, chemistry, computational biology, and machine learning to identify connections between chemistry and disease pathways and develop new therapies.

AI & Machine LearningBiotechDeep TechHealthtech

ProFound Therapeutics discovers and develops therapeutic candidates by analyzing the expanded human proteome, identifying novel proteins from previously uncharacterized genetic sequences that can serve as drug targets for cancer, immune disorders, and metabolic diseases.

AI & Machine LearningBiotechDeep Tech

Avak Kahvejian(Co-founder, Chairman)inYann Echelard(Co-founder)Vini Mani(Co-founder)inErica Weinstein(Co-founder)in

BoardNoubar Afeyan

Co-investorsModi Ventures

Quotient is a biotechnology company applying somatic genetics research to R&D, developing its work through a proprietary platform.

AI & Machine LearningBiotechDeep Tech

Sail Biomedicines develops RNA-based medicines using a platform integrating Endless RNA and targeted nanoparticle delivery technology.

AI & Machine LearningBiotechDeep TechCambridge, US

John Mendlein(Executive Chairman)

Co-investorsNextech InvestQuan Capital

Terrana Biosciences is an agricultural biotech company applying RNA technology to plant health, developing a platform that gives crops new traits such as drought tolerance and shorter ripening times.

AgTechAI & Machine LearningBiotechDeep Tech

Noubar Afeyan(Founder)Ignacio Martinez(Founder)inRyan Rapp(Founder & CEO)in

Vesalius Therapeutics develops a computational platform that identifies distinct disease subtypes within common diseases like heart failure, diabetes, and Alzheimer's by analyzing patient data and gene circuits, then uses proprietary cell-based models to discover targeted drug candidates.

AI & Machine LearningBiotechDeep TechCambridge, US

Yasir Al-Wakeel(CEO)in

Co-investorsARCH Venture Partners

BG Medicine develops and commercializes cardiovascular diagnostic tests to assess heart failure risk and predict cardiovascular events.

BiotechDigital HealthHealthtechMedical DevicesWaltham, US

Stephen Hall(Executive Officer)inPaul Sohmer(Executive Officer, Director)Aram Adourian(Executive Officer)Harry Wilcox(Director)Paul R. Sohmer, M.D.(President and CEO)

Board seatNoubar Afeyan· per SEC Form D · $2.5M raise · filed May 2015

Cambridge, MA clinical-stage biotech developing engineered exosome therapeutics; IPO'd on NASDAQ in 2020, later restructured.

BiotechSeattle, US

Doug Williams(Executive Officer, Director)

BoardSteven Gillis(Director)Eric Lander(Director)

Board seatNoubar Afeyan· per SEC Form D · filed Nov 2015

Co-investorsARCH Venture PartnersEcoR1 Capital

Moderna develops mRNA-based medicines for infectious and serious diseases using its proprietary mRNA platform and design technology.

BiotechDeep TechMedical DevicesCambridge, US

Robert Langer(Director)Noubar Afeyan, Ph.D.(Co-founder and Chairman, Moderna; CEO, Flagship Pioneering)Lorence Kim(Executive Officer)inJames R. Kasinger(Executive Officer)inStephen Hoge(Executive Officer)in

BoardStephane Bancel(Chief Executive Officer)in

Board seatNoubar Afeyan· per SEC Form D

Co-investorsAglae VenturesBlackstone Life SciencesFPVKhosla VenturesPremji InvestRA Capital

BiotechCambridge, US

Robert Connelly(Executive Officer, Director)Garry Menzel(Executive Officer)Jeff Moore(Executive Officer)

BoardJohn Mendlein(Director)

Board seatDavid BerryNoubar Afeyan· per SEC Form D · filed Feb 2016

Co-investorsFidelity InvestmentsFlagship Ventures

BiotechCambridge, US

Torben Straight Nissen(Executive Officer, Director)inJoanne Protano(Executive Officer)inDavid Epstein(Director)Harvey F. Lodish(Director)Michael Rosenblatt(Director)Roger Pomerantz(Director)

Board seatNoubar Afeyan· per SEC Form D

Co-investorsFlagship VenturesKendall Capital Partners

Sana is a biotech company developing engineered cell medicines, including gene therapies for gene modification and delivery, cell replacement therapies using stem cell biology, and manufacturing solutions to improve patient access to these treatments.

BiotechHealthtechMedical DevicesSeattle, US

Richard Mulligan(Director)inHans Bishop(Director)Steve Harr(President and Chief Executive Officer)James J. MacDonald(Executive Officer)Nathan Hardy(Executive Officer)

Board seatGeoffrey von Maltzahn· per SEC Form D

Co-investorsAmerican Family VenturesARCH Venture PartnersF-Prime CapitalInnovating CapitalJDRF T1D FundManta Ray Ventures+1 more

Ampersand provides a declarative integration framework for building bi-directional, customer-configurable product integrations with third-party applications.

Developer ToolsEnterprise SoftwareSaaS

Lauren Long(Founder)in

Co-investors2.12 AngelsMatrixFlex Capital Partners

Ampersand provides deposit administration services and operates as a national authority in the deposit management sector, serving depositors and financial institutions.

Enterprise SoftwareFintechSaaS

Co-investorsPatriot Financial PartnersJAM FINTOPFINTOP Capital

Ampersand builds electric motorcycles, battery packs, swap stations, and AmperOps fleet management software for motorcycle taxi (boda) drivers in Africa, operating a battery-swapping network for commercial e-motos.

CleantechEnergyMobility & Transportation

Co-investorsBeyond CapitalBeyond Capital VenturesBlue Haven InitiativeEcosystem Integrity FundFactor[e] VenturesAlphaMundi Group+2 more

MIT is an educational and research institution in Cambridge, Massachusetts, pursuing teaching, research, and innovation across science, engineering, and other fields.

BiotechEdTechCambridge, US

Co-investorsBeyond Earth VenturesFoundersX VenturesJIMCOLair East LabsMassChallenge MexicoSelvedge Venture

Cellarity develops medicines using artificial intelligence and single-cell biology to address disease at the cellular level rather than targeting individual disease markers.

AI & Machine LearningBiotechDeep TechMedical Devices

Co-investorsAhren Innovation CapitalManta Ray VenturesBlackRock

Cloudflare provides a global cloud network platform delivering security, performance, and development services through sixty-plus integrated services including SASE, application security, and full-stack development infrastructure.

Cloud ComputingCybersecurityDeveloper ToolsSan Francisco, US

Matthew Prince(Founder)inDane Knechtin

Co-investorsApposite CapitalCapitalGEQT VenturesIcon VenturesKhosla VenturesLocalGlobe+14 more

Rockaway Park, US

Yevgeniy Mordkovich(Executive Officer, Director)inBoris Mordkovich(Executive Officer, Director)

Co-investorsGV (Google Ventures)Kaiser Permanente Ventures

EVELO manufactures premium electric bikes designed for comfort and long-distance riding, sold direct-to-consumer with industry-leading warranty and support.

ConsumerDirect to ConsumerE-commerceHardwareMobility & TransportationSeattle, US

Boris Mordkovich

Co-investorsForefront VentureGV (Google Ventures)Kaiser Permanente Ventures

BiotechCambridge, US

Jennifer Glennon(Executive Officer)inBalkrishan (Simba) Gill, Ph.D.(Executive Officer, Director)Duncan McHale(Executive Officer)inWilliam DeVaul(Executive Officer)inMark Bodmer, Ph.D.(Executive Officer)

BoardNoubar B. Afeyan, Ph.D.(Director)

Co-investorsSV Health InvestorsKaiser Permanente Ventures

Harbinger Health develops early cancer detection technology through its Harbinger HX platform, which embeds developmental biology into biomarker discovery, assay design, and model training to detect faint biological signals of early cancer in real-world samples.

AI & Machine LearningBiotechDigital HealthHealthtech

Co-investorsCatalyst

Inari builds insurance infrastructure technology platforms that enable insurers, MGAs, and reinsurers to operate more efficiently through AI automation and integrations.

AI & Machine LearningEnterprise SoftwareInsurTechSaaSBarcelona, ES

Frank Perkins(Chief Executive Officer)

Co-investorsCriteria Venture Tech

Co-investorsInvestX

Parallel computing technology; acquired by Microsoft in 2009.

Co-investorsAscent Venture PartnersBantam Group

Co-investorsKickstart InnovationStage 1 Ventures

Korrus makes the OIO System, a circadian lighting ecosystem consisting of smart bulbs, a spectral-control app, and a light sensor that shift light spectrum through the day to support focus and alertness and remove blue light at night to aid sleep.

ConsumerHardwareWellness & Fitness

Co-investorsEastward Capital PartnersRichmond Global Ventures

KSQ Therapeutics develops eTIL therapies—engineered tumor-infiltrating lymphocyte treatments for solid tumors—using its proprietary CRISPRomics platform to identify and target novel therapeutic candidates through genome-wide CRISPR/Cas9 functional genomic screens.

AI & Machine LearningBiotechMedical DevicesCambridge, US

Tim Wang(Cofounder)JOHN TRZUPEK, PH.D.(TREASURER, SECRETARY & CHIEF FINANCIAL OFFICER)DAVID P. MEEKER, M.D.(PRESIDENT AND CHIEF EXECUTIVE OFFICER)inFRANK STEGMEIER, PH.D.(CHIEF SCIENTIFIC OFFICER)JAMES GILBERT(Director)

BoardALAN L. CRANE(Director)

Co-investorsAlpha Wave GlobalARCH Venture PartnersLAVLG Technology VenturesLilly Asia VenturesBaillie Gifford+1 more

LILA Sciences builds AI systems for autonomous scientific research and discovery across medicine, materials, energy, and defense sectors.

AI & Machine LearningBiotechDeep TechSaaS

Co-investorsCatalio Capital Management, LPDauntless VenturesMarch Capital PartnersModi VenturesCollective GlobalIn-Q-Tel+1 more

Nobelprize.org provides open data about the Nobel Prizes and Nobel Laureates to developers through a REST API and as Linked Data (RDF/SPARQL).

Data & InfrastructureDeveloper ToolsEdTechImpact & Social GoodMedia & EntertainmentStockholm, SE

Repertoire's Decode platform focuses on mapping the immune synapse — the interactions between T cell receptors, epitopes, and HLA molecules — to support the development of medicines targeting cancer and other diseases.

AI & Machine LearningBiotechDeep TechDigital HealthHealthtech

Torben Straight Nissen(Chief Executive Officer)inAnthony Coyle(President, Research and Development)inRobert Andtbacka(Chief Medical Officer)inJohn Delyani(Chief Business Officer)inJan Kisielow(Chief Scientific Officer, Repertoire Immune Medicines (Switzerland) Ltd.)in

Co-investorsSoftBank Vision FundJDRF T1D Fund

Ring provides video doorbells and security cameras that allow homeowners to monitor their property and enhance security across indoor and outdoor spaces.

HardwareIoT

Jamie Siminoff(Founder)in

Co-investorsAmerican Family VenturesCRV (Charles River Ventures)Energy Impact PartnersFelicis VenturesGreen Meadow VenturesGrishin Robotics+8 more

Serif Biomedicines develops DNA-based therapies and nucleic acid delivery technologies for genetic medicine.

BiotechDeep TechDigital HealthMedical DevicesCambridge, US

Jacob Rubens(Chief Executive Officer)in

Co-investorsModi Ventures

BiotechCambridge, US

HOWARD BERNSTEIN(Executive Officer)HOWARD WEISMAN(Executive Officer, Director)

BoardALAN CRANE(Director)ROBERT LANGER(Director)ANUPENDRA SHARMA(Director)HARRY WILCOX(Director)

Co-investorsFlagship VenturesNewpath PartnersPolaris Partners

Tessera Therapeutics develops Gene Writing, a genome engineering technology platform designed to make permanent alterations to the human genome for treating diseases.

BiotechDigital HealthMedical Devices

Geoff von Maltzahn(Founder)inJoseph Romanelli(CEO)

Co-investorsArtis VenturesMarch Capital PartnersOMX VenturesSoftBank Vision FundSolari CapitalToba Capital+4 more

BiotechCambridge, US

Ulrik B. Nielsen(Mr. Nielsen is the President of the Issuer.)Bart Henderson(Mr. Henderson is the CEO and Treasurer of the Issuer.)Doug Lauffenburger(Director)John Dineen(Director)John Hohneker(Director)

BoardDoug Cole(Director)

Valo Health applies technology and data to drug discovery, working across the technology, biotech, and healthcare fields.

AI & Machine LearningBiotechHealthtech

David Berry(Founder)in

Co-investorsAtinum Investment Co. Ltd.BioGenerator VenturesKoch Disruptive Technologies