Flagship Pioneering โ Full Portfolio
55 tracked investments ยท listed companies and verified rows first
Generate:Biomedicines develops protein-based therapeutics using artificial intelligence and machine learning in a field it calls Generative Biology, combining computational protein design with biological engineering.
AI & Machine LearningBiotechDeep TechSomerville, US
Gevorg Grigoryan(Co-Founder & Chief Technology Officer)in
Co-investorsARCH Venture PartnersMarch Capital PartnersNVentures
Seres Therapeutics is a clinical-stage biotechnology company developing therapies composed of rationally selected live bacterial consortia to treat serious diseases through modulation of the human microbiome.
BiotechDigital HealthHealthtechMedical DevicesCambridge, US
Matthew Henn(President and Chief Scientific Officer)
Co-investorsRA CapitalSofinnova Ventures
BiotechCambridge, US
John Aunins(Executive Officer)Eric D. Shaff(Executive Officer)David Cook(Executive Officer)Roger J. Pomerantz(Executive Officer, Director)Roger Pomerantz(Executive Officer, Director)
Board seatDavid BerryNoubar Afeyanยท per SEC Form D ยท $65M raise ยท filed Jan 2015
CIBO provides a software platform for designing, deploying, and measuring regenerative agriculture and conservation programs, including workflow automation, scientific modeling, impact reporting, and a network of advisors managing grower engagement.
AgTechAI & Machine LearningClimate TechSaaSCambridge, US
Bruno Basso(Co-Founder and Special Advisor)David Worn(Executive Officer, Director)Barry Martin(Executive Officer)Ryan Richt(Executive Officer)Dale Sorensen(Executive Officer)Sunand Menon(Executive Chairman & CEO)
Board seatIgnacio MartinezStephen BerensonNoubar Afeyanยท per SEC Form D
Co-investorsGeneration Investment ManagementStage 1 Ventures
Abiologics uses computational design tools to create protein-inspired molecules called Synteins, engineered to avoid the vulnerabilities of natural protein medicines while retaining biological function.
AI & Machine LearningBiotechDeep Tech
Avak Kahvejian(Chairman (Founder / founding CEO))Maria-Chiara Magnone(Chief Scientific Officer)Mike(Chief Innovation Officer & Co-Founder)Jaclyn Dunphy(Co-Founder & Senior Director of Strategy and Research Operations)
Alltrna develops engineered, chemically modified tRNA oligonucleotides as programmable medicines, using proprietary machine learning tools to design tRNA molecules with desired pharmacologic properties.
AI & Machine LearningBiotechDeep TechHealthtech
Michelle Werner(CEO)Lovisa Afzelius(Executive Chair & Founding CEO)Joanne Protano(President & Chief Financial Officer)Dave Hava(Chief Scientific Officer)Nerissa Kreher(Chief Medical Officer)Caroline Kรถhrer(SVP, Discovery Platform)
Apriori Bio applies AI/ML combined with biological insights to predict how viruses evolve and to design vaccines, assessing their expected performance before clinical trials.
AI & Machine LearningBiotechDeep TechHealthtech
Cloud ComputingData & InfrastructureEnterprise SoftwareAustin, US
Jonathan Ring(Executive Officer, Director)Paul Carpentier(Director)George Teixeira(Chairman of the Board, Co-founder)inJohn Bocskor(Former DataCore Vice President, Product Development and Co-founder)Dave Zabrowski(Chief Executive Officer)inKevin Thimble(Chief Financial Officer)in
Co-investorsInsight PartnersNew Science Ventures
Etiome develops stage-specific medicines by applying single-cell omics and artificial intelligence to map disease progression and identify disease-modifying targets at early biological inflection points for preemptive intervention.
AI & Machine LearningBiotechLongevity
Katharine von Herrmann(Co-founder)Avak Kahvejian(Founding Team; Founding CEO)Noubar Afeyan(Founding Team)Scott Lipnick(Founding Team)Torben Straight Nissen(Founding Team; Board Director)Yann Echelard(Founding Team; Chief Operating Officer)
Inari applies artificial intelligence and gene editing to accelerate plant breeding, delivering crop improvement solutions for farmers focused on soybeans, corn, and wheat across broadacre agriculture.
AgTechAI & Machine LearningBiotechCambridge, US
Lisa Safarian(CEO)Stuart Brown(Chief Financial Officer)Pierre-Etienne Boin(Secretary and General Counsel)Ponsi Trivisvavet(President and Chief Executive Officer)
BoardRobert Berendes, Ph.D.(Director)Ignacio Martinez(Director)in
Co-investorsAcre Venture PartnersCongruent VenturesG Squared
Metaphore develops a platform that measures biological activity inside cells at scale to design antibody medicines with novel mechanisms of action.
AI & Machine LearningBiotechDeep TechMedical Devices
Co-investorsGlobal Brain
Montai is a drug discovery company that combines human biology, chemistry, computational biology, and machine learning to identify connections between chemistry and disease pathways and develop new therapies.
AI & Machine LearningBiotechDeep TechHealthtech
Quotient is a biotechnology company applying somatic genetics research to R&D, developing its work through a proprietary platform.
AI & Machine LearningBiotechDeep Tech
Sail Biomedicines develops programmable RNA medicines using circular RNA technology (Endless RNA/eRNA) and targeted nanoparticles for delivery, applying generative AI to design therapies.
AI & Machine LearningBiotechDeep Tech
Co-investorsNextech InvestQuan Capital
Terrana Biosciences is an agricultural biotech company applying RNA technology to plant health, developing a platform that gives crops new traits such as drought tolerance and shorter ripening times.
AgTechAI & Machine LearningBiotechDeep Tech
Noubar Afeyan(Founder)Ignacio Martinez(Founder)Ryan Rapp(Founder & CEO)
Vesalius Therapeutics develops a computational platform that identifies distinct disease subtypes within common diseases like heart failure, diabetes, and Alzheimer's by analyzing patient data and gene circuits, then uses proprietary cell-based models to discover targeted drug candidates.
AI & Machine LearningBiotechDeep TechCambridge, US
Yasir Al-Wakeel(CEO)in
Co-investorsARCH Venture Partners
BG Medicine develops the BGM Galectin-3 test, a diagnostic blood test marker used in the assessment of cardiac fibrosis.
BiotechHealthtechMedical DevicesWaltham, US
Stephen Hall(Executive Officer)Paul Sohmer(Executive Officer, Director)Aram Adourian(Executive Officer)Harry Wilcox(Director)
BoardTimothy Harris(Director)
Board seatNoubar Afeyanยท per SEC Form D ยท $2.5M raise ยท filed May 2015
Cambridge, MA clinical-stage biotech developing engineered exosome therapeutics; IPO'd on NASDAQ in 2020, later restructured.
BiotechSeattle, US
Doug Williams(Executive Officer, Director)
BoardSteven Gillis(Director)Eric Lander(Director)
Board seatNoubar Afeyanยท per SEC Form D ยท filed Nov 2015
Co-investorsARCH Venture PartnersEcoR1 Capital
Moderna develops mRNA-based medicines for infectious and serious diseases using its proprietary mRNA platform and design technology.
BiotechDeep TechMedical DevicesCambridge, US
Robert Langer(Director)Lorence Kim(Executive Officer)James R. Kasinger(Executive Officer)Stephen Hoge(Executive Officer)Theo Melas-Kyriazi(Director)Robert Carpenter(Director)
Board seatNoubar Afeyanยท per SEC Form D
Co-investorsAglae VenturesBlackstone Life SciencesFPVKhosla VenturesPremji InvestRA Capital
BiotechCambridge, US
Robert Connelly(Executive Officer, Director)Garry Menzel(Executive Officer)Jeff Moore(Executive Officer)
BoardJohn Mendlein(Director)
Board seatDavid BerryNoubar Afeyanยท per SEC Form D ยท filed Feb 2016
BiotechCambridge, US
Torben Straight Nissen(Executive Officer, Director)Joanne Protano(Executive Officer)David Epstein(Director)Harvey F. Lodish(Director)Michael Rosenblatt(Director)Roger Pomerantz(Director)
Board seatNoubar Afeyanยท per SEC Form D ยท $120M raise ยท filed Jun 2017
Co-investorsKendall Capital Partners
Sana is a biotech company developing engineered cell medicines, including gene therapies for gene modification and delivery, cell replacement therapies using stem cell biology, and manufacturing solutions to improve patient access to these treatments.
BiotechHealthtechMedical DevicesSeattle, US
Steve Harr(President and Chief Executive Officer)
Board seatGeoffrey von Maltzahnยท per SEC Form D
Co-investorsAmerican Family VenturesARCH Venture PartnersF-Prime CapitalInnovating CapitalJDRF T1D FundManta Ray Ventures+1 more
Ampersand provides a declarative integration framework for building bi-directional, customer-configurable product integrations with third-party applications.
Developer ToolsEnterprise SoftwareSaaS
Lauren Long(Founder)in
Co-investors2.12 AngelsMatrixFlex Capital Partners
Ampersand is a cash management platform that places large business deposits across a network of FDIC- and NCUA-insured banks and credit unions, extending deposit insurance coverage and providing competitive yields on idle cash.
Enterprise SoftwareFintechSaaS
Co-investorsFINTOP CapitalPatriot Financial Partners
Ampersand builds electric motorcycles, battery packs, swap stations, and AmperOps fleet management software for motorcycle taxi (boda) drivers in Africa, operating a battery-swapping network for commercial e-motos.
CleantechEnergyMobility & Transportation
Co-investorsBeyond CapitalBeyond Capital VenturesEcosystem Integrity FundFactor[e] Ventures
MIT is an educational and research institution in Cambridge, Massachusetts, pursuing teaching, research, and innovation across science, engineering, and other fields.
BiotechEdTechCambridge, US
Co-investorsBeyond Earth VenturesFoundersX VenturesJIMCOLair East LabsMassChallenge MexicoSelvedge Venture
Cellarity develops therapeutics using AI-powered multi-omics analysis to identify and correct dysfunctional cellular states, treating complex diseases by regulating genetic pathways rather than targeting single genes.
AI & Machine LearningBiotechMedical Devices
Co-investorsAhren Innovation CapitalManta Ray Ventures
Cloudflare provides a global cloud network platform delivering security, performance, and development services through sixty-plus integrated services including SASE, application security, and full-stack development infrastructure.
Cloud ComputingCybersecurityDeveloper ToolsSan Francisco, US
Matthew Prince(Founder)inDane Knechtin
Co-investorsApposite CapitalEQT VenturesIcon VenturesKhosla VenturesLocalGlobeLSP (Life Sciences Partners)+7 more
BiotechCambridge, US
Jennifer Glennon(Executive Officer)Balkrishan (Simba) Gill, Ph.D.(Executive Officer, Director)Duncan McHale(Executive Officer)William DeVaul(Executive Officer)Mark Bodmer, Ph.D.(Executive Officer)
BoardNoubar B. Afeyan, Ph.D.(Director)
Co-investorsSV Health InvestorsKaiser Permanente Ventures
Harbinger Health develops early cancer detection technology through its Harbinger HX platform, which embeds developmental biology into biomarker discovery, assay design, and model training to detect faint biological signals of early cancer in real-world samples.
AI & Machine LearningBiotechDigital HealthHealthtech
Inari analyzes customer feedback, support tickets, and CRM data to identify product opportunities and customer insights, automatically surfacing relevant information and linking findings to backlog items.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US
Frank Lee(Founder)inEric Kim(Founder)in
Co-investorsY Combinator
Co-investorsInvestX
Co-investorsKickstart InnovationStage 1 Ventures
Korrus develops circadian lighting technology based on research into light and human biology, holding over 500 patents.
ConsumerHardwareIoTWellness & Fitness
Co-investorsEastward Capital PartnersRichmond Global Ventures
KSQ Therapeutics develops eTIL therapiesโengineered tumor-infiltrating lymphocyte treatments for solid tumorsโusing its proprietary CRISPRomics platform to identify and target novel therapeutic candidates through genome-wide CRISPR/Cas9 functional genomic screens.
AI & Machine LearningBiotechMedical DevicesCambridge, US
Tim Wang(Cofounder)JOHN TRZUPEK, PH.D.(TREASURER, SECRETARY & CHIEF FINANCIAL OFFICER)DAVID P. MEEKER, M.D.(PRESIDENT AND CHIEF EXECUTIVE OFFICER)FRANK STEGMEIER, PH.D.(CHIEF SCIENTIFIC OFFICER)JAMES GILBERT(Director)
BoardALAN L. CRANE(Director)
Co-investorsAlpha Wave GlobalARCH Venture PartnersLAVLilly Asia VenturesBaillie GiffordPolaris Partners
LILA Sciences builds AI systems for autonomous scientific research and discovery across medicine, materials, energy, and defense sectors.
AI & Machine LearningBiotechDeep TechSaaS
Co-investorsCatalio Capital Management, LPDauntless VenturesMarch Capital PartnersModi VenturesCollective GlobalIn-Q-Tel+1 more
Nobelprize.org provides open data about the Nobel Prizes and Nobel Laureates to developers through a REST API and as Linked Data (RDF/SPARQL).
Data & InfrastructureDeveloper ToolsEdTechImpact & Social GoodMedia & EntertainmentStockholm, SE
ProFound Therapeutics identifies previously undiscovered proteins encoded by the human genome and characterizes their biological functions to find new drug targets and therapeutic proteins.
BiotechDeep Tech
Co-investorsModi Ventures
Repertoire's Decode platform focuses on mapping the immune synapse โ the interactions between T cell receptors, epitopes, and HLA molecules โ to support the development of medicines targeting cancer and other diseases.
AI & Machine LearningBiotechDeep TechDigital HealthHealthtech
Torben Straight Nissen(Chief Executive Officer)Anthony Coyle(President, Research and Development)Robert Andtbacka(Chief Medical Officer)John Delyani(Chief Business Officer)Jan Kisielow(Chief Scientific Officer, Repertoire Immune Medicines (Switzerland) Ltd.)
Co-investorsSoftBank Vision FundJDRF T1D Fund
Ring provides video doorbells and security cameras that allow homeowners to monitor their property and enhance security across indoor and outdoor spaces.
HardwareIoT
Jamie Siminoff(Founder)in
Co-investorsAmerican Family VenturesCRV (Charles River Ventures)Energy Impact PartnersFelicis VenturesGreen Meadow VenturesGrishin Robotics+8 more
Google is a technology company that provides tools and products designed with privacy, security, and responsible AI practices as foundational principles.
AI & Machine LearningCloud ComputingCybersecurity
Co-investors82VSAdvantage Capital PartnersBain Capital VenturesDCVC (Data Collective)EQT VenturesHeartcore Capital+9 more
Serif Biomedicines develops technology to write DNA in different forms so that DNA can be used as a medicine, aiming to create a new category of genetic medicines to treat and prevent disease.
BiotechDeep Tech
Co-investorsModi Ventures
Audio distribution and music-sharing platform for artists and creators.
Berlin, DE
Eric Quidenus-Wahlforss(Founder)in
Co-investorsAtlanticAtlantic LabsBirk VentureEdge Case Capital PartnersGerman Startups GroupIVP (Institutional Venture Partners)+6 more
Tessera Therapeutics develops Gene Writing, a genome engineering technology platform designed to make permanent alterations to the human genome for treating diseases.
BiotechDigital HealthMedical Devices
Co-investorsArtis VenturesMarch Capital PartnersOMX VenturesSoftBank Vision FundSolari CapitalToba Capital+4 more
Rows marked โSEC filingโ are inferred from directors named on the company's SEC Form D โ public regulatory data, not a portfolio list published by the firm.