Flagship Pioneering — Full Portfolio

Generate:Biomedicines develops protein-based therapeutics using artificial intelligence and machine learning in a field it calls Generative Biology, combining computational protein design with biological engineering.

AI & Machine LearningBiotechDeep TechSomerville, US

GGGevorg Grigoryan(Founder)inMNMichael Nally(Chief Executive Officer)inAvak Kahvejian(Founder)Geoffrey von Maltzahn(Founder)Molly Gibson(Founder)

Co-investorsALAlumni VenturesARARCH Venture PartnersMAMarch Capital PartnersALAlaska Permanent Fund CorporationALALTITUDE LIFE SCIENCE VENTURESALAltitude Ventures Management, Llc+3 more

Denali Therapeutics develops therapeutics for neurodegenerative diseases.

BiotechHealthtechMedical DevicesSan Francisco, US

MTMarc Tessier-Lavigne(Founder)inAOAlexander O. Schuth(Executive Officer)inRyan J. Watts(President, Chief Executive Officer and Director)inCarole Ho(Executive Officer)inSESteve E. Krognes(Director)inAlexander Schuth(Founder)

Co-investorsARARCH Venture PartnersECEcoR1 CapitalF-F-Prime CapitalFOForesite CapitalGVGV (Google Ventures)FLFlagship Ventures

Foghorn Therapeutics is a clinical-stage biotech developing chromatin-targeted cancer drugs via its Gene Traffic Control platform, including a candidate co-developed with Eli Lilly.

AGAdrian Gottschalk(President and Chief Executive Officer)

Co-investorsXEXeraya CapitalBIBiotechnology Value FundDEDeerfield Management Company

TransMedics develops and sells the Organ Care System (OCS), a portable warm perfusion platform for preserving and assessing donor hearts, lungs, and livers outside the body prior to transplantation, along with the National OCS Program, an end-to-end organ procurement and logistics service for transplant centers that includes aircraft and ground transportation.

HealthtechAndover, US

Waleed H. Hassanein(Executive Officer, Director)inStephen Gordon(Executive Officer)

BoardEdwin M. Kania, Jr.(Director)David Abrams(Director)Joseph S. Lacob(Director)Travis Rhodes(Director)

Co-investorsALAlta Partners

CIBO provides a software platform for designing, deploying, and measuring regenerative agriculture and conservation programs, including workflow automation, scientific modeling, impact reporting, and a network of advisors managing grower engagement.

AgTechAI & Machine LearningClimate TechSaaSCambridge, US

BBBruno Basso(Co-Founder and Special Advisor)David Worn(Executive Officer, Director)inBMBarry Martin(Executive Officer)inRRRyan Richt(Executive Officer)inDale Sorensen(Executive Officer)Sunand Menon(Executive Chairman & CEO)in

Board seatIMIgnacio MartinezSBStephen BerensonNANoubar Afeyan· per SEC Form D

Co-investorsGEGeneration Investment ManagementSTStage 1 Ventures

Abiologics uses computational design tools to create protein-inspired molecules called Synteins, engineered to avoid the vulnerabilities of natural protein medicines while retaining biological function.

AI & Machine LearningBiotechDeep Tech

AKAvak Kahvejian(Chairman (Founder / founding CEO))inMike(Chief Innovation Officer & Co-Founder)JDJaclyn Dunphy(Co-Founder & Senior Director of Strategy and Research Operations)inMMMaria-Chiara Magnone(Chief Scientific Officer)in

Alltrna develops engineered, chemically modified tRNA oligonucleotides as programmable medicines, using proprietary machine learning tools to design tRNA molecules with desired pharmacologic properties.

AI & Machine LearningBiotechDeep TechHealthtech

LALovisa Afzelius(Executive Chair & Founding CEO)inMWMichelle Werner(CEO)inJPJoanne Protano(President & Chief Financial Officer)inDHDave Hava(Chief Scientific Officer)inNKNerissa Kreher(Chief Medical Officer)inCKCaroline Köhrer(SVP, Discovery Platform)in

Apriori Bio applies AI/ML combined with biological insights to predict how viruses evolve and to design vaccines, assessing their expected performance before clinical trials.

AI & Machine LearningBiotechDeep TechHealthtech

Co-investorsGLGlobal Health Investment Corporation

Cloud ComputingData & InfrastructureEnterprise SoftwareAustin, US

Jonathan Ring(Executive Officer, Director)Paul Carpentier(Director)GTGeorge Teixeira(Chairman of the Board, Co-founder)inJohn Bocskor(Former DataCore Vice President, Product Development and Co-founder)inMark Goros(Executive Officer, Director)Dave Zabrowski(Chief Executive Officer)in

Co-investorsINInsight PartnersNENew Science VenturesADAdvantage Capital Partners

Etiome develops stage-specific medicines by applying single-cell omics and artificial intelligence to map disease progression and identify disease-modifying targets at early biological inflection points for preemptive intervention.

AI & Machine LearningBiotechLongevity

KVKatharine von Herrmann(Co-founder)inAKAvak Kahvejian(Founding Team; Founding CEO)inNANoubar Afeyan(Founding Team)inSLScott Lipnick(Founding Team)inTorben Straight Nissen(Founding Team; Board Director)inYEYann Echelard(Founding Team; Chief Operating Officer)

Inari applies artificial intelligence and gene editing to accelerate plant breeding, delivering crop improvement solutions for farmers focused on soybeans, corn, and wheat across broadacre agriculture.

AgTechAI & Machine LearningBiotechCambridge, US

LSLisa Safarian(CEO)inStuart Brown(Chief Financial Officer)PBPierre-Etienne Boin(Secretary and General Counsel)inPTPonsi Trivisvavet(President and Chief Executive Officer)inDavid Berry(Founder)

BoardRobert Berendes, Ph.D.(Director)

Co-investorsACAcre Venture PartnersCOCongruent VenturesG G SquaredCPCPP Investments

DataCore develops software-defined storage and object storage solutions for enterprises to virtualize and manage storage infrastructure across primary, secondary, and archive environments.

Cloud ComputingData & InfrastructureEnterprise Software

GTGeorge Teixeira(Chairman of the Board, Co-founder)inJohn Bocskor(Co-founder, Former Vice President of Product Development)in

Co-investorsINInsight PartnersPAPartners for GrowthPAPartners for Growth (PFG)UTUtiliti GroupAMAME Cloud Ventures

Metaphore develops a platform that measures biological activity inside cells at scale to design antibody medicines with novel mechanisms of action.

AI & Machine LearningBiotechDeep TechMedical Devices

Co-investorsGLGlobal Brain

Montai is a drug discovery company that combines human biology, chemistry, computational biology, and machine learning to identify connections between chemistry and disease pathways and develop new therapies.

AI & Machine LearningBiotechDeep TechHealthtech

ProFound Therapeutics discovers and develops therapeutic candidates by analyzing the expanded human proteome, identifying novel proteins from previously uncharacterized genetic sequences that can serve as drug targets for cancer, immune disorders, and metabolic diseases.

AI & Machine LearningBiotechDeep Tech

AKAvak Kahvejian(Co-founder, Chairman)inYann Echelard(Co-founder)VMVini Mani(Co-founder)inEWErica Weinstein(Co-founder)in

BoardNANoubar Afeyanin

Co-investorsMOModi Ventures

Quotient is a biotechnology company applying somatic genetics research to R&D, developing its work through a proprietary platform.

AI & Machine LearningBiotechDeep Tech

Sail Biomedicines develops RNA-based medicines using a platform integrating Endless RNA and targeted nanoparticle delivery technology.

AI & Machine LearningBiotechDeep TechCambridge, US

John Mendlein(Executive Chairman)

Co-investorsNENextech InvestQUQuan Capital

Terrana Biosciences is an agricultural biotech company applying RNA technology to plant health, developing a platform that gives crops new traits such as drought tolerance and shorter ripening times.

AgTechAI & Machine LearningBiotechDeep Tech

NANoubar Afeyan(Founder)inIMIgnacio Martinez(Founder)inRRRyan Rapp(Founder & CEO)in

Vesalius Therapeutics develops a computational platform that identifies distinct disease subtypes within common diseases like heart failure, diabetes, and Alzheimer's by analyzing patient data and gene circuits, then uses proprietary cell-based models to discover targeted drug candidates.

AI & Machine LearningBiotechDeep TechCambridge, US

YAYasir Al-Wakeel(CEO)in

Co-investorsARARCH Venture PartnersSOSofinnova Ventures

BG Medicine develops and commercializes cardiovascular diagnostic tests to assess heart failure risk and predict cardiovascular events.

BiotechDigital HealthHealthtechMedical DevicesWaltham, US

Stephen Hall(Executive Officer)inPaul Sohmer(Executive Officer, Director)Aram Adourian(Executive Officer)Harry Wilcox(Director)Paul R. Sohmer, M.D.(President and CEO)

Board seatNANoubar Afeyan· per SEC Form D · $2.5M raise · filed May 2015

Cambridge, MA clinical-stage biotech developing engineered exosome therapeutics; IPO'd on NASDAQ in 2020, later restructured.

BiotechSeattle, US

DWDoug Williams(Executive Officer, Director)in

BoardSteven Gillis(Director)Eric Lander(Director)

Board seatNANoubar Afeyan· per SEC Form D

Co-investorsARARCH Venture PartnersECEcoR1 CapitalALAlexandriaFIFidelity InvestmentsQAQatar Investment Authority

Moderna develops mRNA-based medicines for infectious and serious diseases using its proprietary mRNA platform and design technology.

BiotechDeep TechMedical DevicesCambridge, US

RLRobert Langer(Founder)NANoubar Afeyan, Ph.D.(Co-founder and Chairman, Moderna; CEO, Flagship Pioneering)LKLorence Kim(Executive Officer)inJRJames R. Kasinger(Executive Officer)inSHStephen Hoge(Executive Officer)inDerrick Rossi(Founder)

Board seatNANoubar Afeyan· per SEC Form D

Co-investorsAGAglae VenturesBLBlackstone Life SciencesFPFPVKHKhosla VenturesLILingottoPRPremji Invest+5 more

BiotechCambridge, US

TSTorben Straight Nissen(Executive Officer, Director)inJPJoanne Protano(Executive Officer)inDavid Epstein(Director)Harvey F. Lodish(Director)Michael Rosenblatt(Director)RPRoger Pomerantz(Director)in

Board seatNANoubar Afeyan· per SEC Form D

Co-investorsFLFlagship VenturesKEKendall Capital Partners

Sana is a biotech company developing engineered cell medicines, including gene therapies for gene modification and delivery, cell replacement therapies using stem cell biology, and manufacturing solutions to improve patient access to these treatments.

BiotechHealthtechMedical DevicesSeattle, US

RMRichard Mulligan(Director)inHBHans Bishop(Founder)SHSteve Harr(Founder)JJJames J. MacDonald(Executive Officer)NHNathan Hardy(Executive Officer)

Board seatGVGeoffrey von Maltzahn· per SEC Form D

Co-investorsAMAmerican Family VenturesARARCH Venture PartnersCACatalytic Impact FoundationF-F-Prime CapitalGVGV (Google Ventures)INInnovating Capital+8 more

Ampersand provides a declarative integration framework for building bi-directional, customer-configurable product integrations with third-party applications.

Developer ToolsEnterprise SoftwareSaaS

LLLauren Long(Founder)in

Co-investors2.2.12 AngelsMAMana VenturesMAMatrixFLFlex Capital Partners

Ampersand provides deposit administration services and operates as a national authority in the deposit management sector, serving depositors and financial institutions.

Enterprise SoftwareFintechSaaS

Co-investorsPAPatriot Financial PartnersJAJAM FINTOPFIFINTOP Capital

Ampersand builds electric motorcycles, battery packs, swap stations, and AmperOps fleet management software for motorcycle taxi (boda) drivers in Africa, operating a battery-swapping network for commercial e-motos.

CleantechEnergyMobility & Transportation

Co-investorsBEBeyond CapitalBEBeyond Capital VenturesBLBlue Haven InitiativeECEcosystem Integrity FundFAFactor[e] VenturesALAlphaMundi Group+2 more

Ampersand Biomedicines develops programmable, multi-specific biologic therapies designed to act only at the site of disease, aiming to reduce off-tissue side effects and toxicities.

AI & Machine LearningBiotechDeep Tech

BiotechHealthtechMedical DevicesWaltham, US

David F. Muller(Executive Officer, Director)inBJBrian J. Roberts(Executive Officer)inRJRhonda J. Bracey(Executive Officer)in

BoardJason Hong(Director)JDJeff Dykan(Director)inANAnthony Natale(Director)in

Co-investorsAPAPERTURE Venture PartnersLALAVLILilly Asia VenturesSCSCP Vitalife PartnersTHThird Point VenturesABAbingworth+4 more

MIT is an educational and research institution in Cambridge, Massachusetts, pursuing teaching, research, and innovation across science, engineering, and other fields.

BiotechEdTechCambridge, US

Co-investorsBEBeyond Earth VenturesFOFoundersX VenturesJIJIMCOLALair East LabsMAMassChallenge MexicoSESelvedge Venture

Cellarity develops medicines using artificial intelligence and single-cell biology to address disease at the cellular level rather than targeting individual disease markers.

AI & Machine LearningBiotechDeep TechMedical Devices

Avak Kahvejian Nick Plugis(Founder)

Co-investorsAHAhren Innovation CapitalMAManta Ray VenturesBLBlackRock

Cloudflare provides a global cloud network platform delivering security, performance, and development services through sixty-plus integrated services including SASE, application security, and full-stack development infrastructure.

Cloud ComputingCybersecurityDeveloper ToolsSan Francisco, US

MPMatthew Prince(Founder)inMZMichelle Zatlyn(Co-founder and President)inLee Holloway(Founder)DKDane Knecht(Chief Technology Officer)inThomas Seifert(Chief Financial Officer)inASAlissa Starzak(Chief Legal Officer and Secretary)in

Co-investorsAPApposite CapitalCACapitalGEQEQT Life SciencesEQEQT VenturesICIcon VenturesIRIrregular Expressions+18 more

EVELO manufactures premium electric bikes designed for comfort and long-distance riding, sold direct-to-consumer with industry-leading warranty and support.

ConsumerDirect to ConsumerE-commerceHardwareMobility & TransportationSeattle, US

YMYevgeniy Mordkovich(Executive Officer, Director)inBoris Mordkovich

Co-investorsFOForefront VentureALAlexandriaGVGV (Google Ventures)KAKaiser Permanente Ventures

BiotechCambridge, US

JGJennifer Glennon(Executive Officer)inBalkrishan (Simba) Gill, Ph.D.(Executive Officer, Director)Duncan McHale(Executive Officer)inWDWilliam DeVaul(Executive Officer)inMark Bodmer, Ph.D.(Executive Officer)

BoardNoubar B. Afeyan, Ph.D.(Director)

Co-investorsGVGV (Google Ventures)SVSV Health InvestorsALAlexandriaKAKaiser Permanente VenturesMAMayo Clinic Ventures

Expedition Medicines is a drug discovery company applying artificial intelligence and covalent chemistry to design medicines targeting disease-driving proteins.

AI & Machine LearningBiotechDeep Tech

Extuitive provides AI skills for growth marketers that plug into AI coding assistants like Codex and Claude, currently offering bulk uploading of Meta ad creatives to speed up ad setup.

AdTechAI & Machine LearningMarketing Tech

Harbinger Health develops early cancer detection technology through its Harbinger HX platform, which embeds developmental biology into biomarker discovery, assay design, and model training to detect faint biological signals of early cancer in real-world samples.

AI & Machine LearningBiotechDigital HealthHealthtech

Co-investorsCACatalyst

Inari builds insurance infrastructure technology platforms that enable insurers, MGAs, and reinsurers to operate more efficiently through AI automation and integrations.

AI & Machine LearningEnterprise SoftwareInsurTechSaaSBarcelona, ES

FPFrank Perkins(Chief Executive Officer)

Co-investorsCRCriteria Venture Tech

Parallel computing technology; acquired by Microsoft in 2009.

Co-investorsASAscent Venture PartnersBABantam Group

Kaleido offers a modular enterprise platform with pre-integrated products for tokenization, custody, digital assets, middleware, interoperability, and blockchain infrastructure.

Crypto & Web3Data & InfrastructureEnterprise Software

SCSteve Cerveny(Founder)inSLSophia Lopez(Founder)in

Co-investorsCOConsenSys MeshVAValor Capital GroupEQEQT Life SciencesINInnovation IndustriesINInvest-NLMEMenlo Ventures+1 more

Korrus makes the OIO System, a circadian lighting ecosystem consisting of smart bulbs, a spectral-control app, and a light sensor that shift light spectrum through the day to support focus and alertness and remove blue light at night to aid sleep.

ConsumerHardwareWellness & Fitness

Co-investorsEAEastward Capital PartnersRIRichmond Global Ventures

KSQ Therapeutics develops eTIL therapies—engineered tumor-infiltrating lymphocyte treatments for solid tumors—using its proprietary CRISPRomics platform to identify and target novel therapeutic candidates through genome-wide CRISPR/Cas9 functional genomic screens.

AI & Machine LearningBiotechMedical DevicesCambridge, US

Tim Wang(Cofounder)JTJOHN TRZUPEK, PH.D.(TREASURER, SECRETARY & CHIEF FINANCIAL OFFICER)DPDAVID P. MEEKER, M.D.(PRESIDENT AND CHIEF EXECUTIVE OFFICER)inFRANK STEGMEIER, PH.D.(CHIEF SCIENTIFIC OFFICER)Qasim Rizvi(Chief Executive Officer)inJAMES GILBERT(Director)

Co-investorsALAlpha Wave GlobalARARCH Venture PartnersLALAVLGLG Technology VenturesLILilly Asia VenturesBABaillie Gifford+3 more

LILA Sciences builds AI systems for autonomous scientific research and discovery across medicine, materials, energy, and defense sectors.

AI & Machine LearningBiotechDeep TechSaaS

Geoffrey von Maltzahn(Founder)Molly Gibson(Founder)Noubar Afeyan(Founder)

Co-investorsALAlumni VenturesCACatalio Capital Management, LPDADauntless VenturesGEGeneral CatalystINIn-Q-TelMAMarch Capital Partners+8 more

Co-investorsVAVantagePoint Capital Partners

Mirai Bio develops lipid nanoparticle (LNP) delivery systems for nucleic acid therapeutics, combining cargo design, proprietary lipid chemistry, cell-specific targeting, in vivo evaluation, and manufacturability into a single development process.

AI & Machine LearningBiotechDeep Tech

Kate Torchilin(President & CEO)

Nobelprize.org provides open data about the Nobel Prizes and Nobel Laureates to developers through a REST API and as Linked Data (RDF/SPARQL).

Data & InfrastructureDeveloper ToolsEdTechImpact & Social GoodMedia & EntertainmentStockholm, SE

Novomer (part of Danimer Scientific) develops biodegradable and compostable materials used in everyday products such as packaging and straws.

BiotechCircular EconomyNew Materials

Co-investorsSASaints CapitalARAramco Ventures

Prologue Medicines develops therapeutics derived from viral proteins, using a computational platform to mine the viral proteome for proteins that can modulate human physiology and treat disease.

AI & Machine LearningBiotechDeep Tech

Repertoire's Decode platform focuses on mapping the immune synapse — the interactions between T cell receptors, epitopes, and HLA molecules — to support the development of medicines targeting cancer and other diseases.

AI & Machine LearningBiotechDeep TechDigital HealthHealthtech

TSTorben Straight Nissen(Chief Executive Officer)inACAnthony Coyle(President, Research and Development)inRARobert Andtbacka(Chief Medical Officer)inJDJohn Delyani(Chief Business Officer)inJKJan Kisielow(Chief Scientific Officer, Repertoire Immune Medicines (Switzerland) Ltd.)in

Co-investorsSOSoftBank Vision FundJDJDRF T1D Fund

Ring provides video doorbells and security cameras that allow homeowners to monitor their property and enhance security across indoor and outdoor spaces.

HardwareIoT

JSJamie Siminoff(Founder)in

Co-investorsAMAmerican Family VenturesCRCRV (Charles River Ventures)ENEnergy Impact PartnersFEFelicis VenturesGRGreen Meadow VenturesGRGrishin Robotics+14 more

Ring Therapeutics develops vector-based targeted medicines using its Vectorology platform, which engineers conjugates derived from human commensal viruses to deliver diverse therapeutic payloads to specific tissues and cells.

BiotechDeep Tech

Chris McNulty(CEO)

Co-investorsBOBoutique Venture PartnersSTStage 1 Ventures

Serif Biomedicines develops DNA-based therapies and nucleic acid delivery technologies for genetic medicine.

BiotechDeep TechDigital HealthMedical DevicesCambridge, US

JRJacob Rubens(Chief Executive Officer)in

Co-investorsMOModi Ventures

Seventh Sense develops face-based biometric authentication solutions that verify identity without storing facial data, serving organizations and individuals needing secure access control, document signing, and identity verification.

AI & Machine LearningCybersecurityDeep TechDigital HealthSingapore, SG

Ashish KushwahaSam TsuiVarun Chatterji

Co-investors50500 GlobalFLFlagship VenturesNENewpath Partners

Syros Pharmaceuticals is a Massachusetts gene-control biotech developing small molecules that regulate disease gene expression.

BiotechCambridge, US

Nancy Simonian(CEO)Peter Wirth(Director)Mark Alles(Director)Philip Sharp(Director)Richard A. Young(Director)Sue Gail Eckhardt(Director)

Co-investorsAIAisling CapitalARARCH Venture PartnersQUQuan CapitalALAlexandriaALAlly Bridge GroupBABain Capital+11 more

Terion operates an independent agricultural technology platform that turns field-level data, remote sensing, ecosystem models, and AI analytics into insights for crop planning, program enrollment, sustainability, and supply-chain traceability.

AgTechAI & Machine LearningSaaSBoston, US

Tessera Therapeutics develops Gene Writing, a genome engineering technology platform designed to make permanent alterations to the human genome for treating diseases.

BiotechDigital HealthMedical Devices

GVGeoff von Maltzahn(Founder)inJRJoseph Romanelli(CEO)Geoffrey von Maltzahn(Founder)Jacob Rubens(Founder)Noubar Afeyan(Founder)Rob Citorik(Founder)

Co-investorsARArtis VenturesMAMarch Capital PartnersOMOMX VenturesSOSoftBank Vision FundSOSolari CapitalTOToba Capital+6 more

Torque delivers DevOps functions as an outsourced service for organizations operating at scale.

Cloud ComputingDeveloper ToolsFalmouth, US

Co-investorsTETechstars

Valo Health applies technology and data to drug discovery, working across the technology, biotech, and healthcare fields.

AI & Machine LearningBiotechHealthtech

DBDavid Berry(Founder)in

Co-investorsATAtinum Investment Co. Ltd.BIBioGenerator VenturesHBHBM Healthcare InvestmentsHBHBM PartnersKOKoch Disruptive Technologies