Chamaeleon
Venture capitalActively deployingSilicon Valley · Pre-Seed–Series A · 6 people tracked
Investment thesis
Chamaeleon is an early-stage VC firm based in Silicon Valley investing globally in truly transformative companies. Founded by three partners with backgrounds as investors, operators and entrepreneurs, the firm applies a proprietary AI and quantitative engine (MANTIS) that analyzes millions of companies across thousands of data points to identify opportunities. It aims to be a value-add partner, supporting both early startups and established players, and prioritizes partnering with people aligned on shared values and long-standing relationships, whom it refers to as its community or 'KIN.'
Source: firm website, verified Aug 3, 2026.
Team · 6 people
from public directories
What they invest in
from 32 of 55 portfolio companiesSaaS ×12AI & Machine Learning ×11Enterprise Software ×7Consumer ×6Developer Tools ×5Cloud Computing ×3Crypto & Web3 ×3Cybersecurity ×3
HQs:United States×15Japan×1Portugal×1
Investments · 55 tracked
founders shown can be your intro pathBy year:2024 · 22022 · 12019 · 12017 · 15 dated
SportsEngine Play is a streaming platform for watching live and on-demand youth sports events, games, and tournaments, accessible via web and a mobile app.
ConsumerMedia & EntertainmentSports Tech
AI-powered smart chicken coops for backyard food production
DeepInfra provides inference infrastructure for deploying open-source AI models at scale, built from GPU hardware to API layer.
AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsPalo Alto, US
Nikola Borisov(Executive Officer, Director)Yessenzhar Kanapin(Executive Officer, Director)Georgios Papoutsis(Executive Officer, Director)
Dover, US
Veronica Orvalho(Executive Officer, Director)Dominic Gualtieri(Executive Officer, Director)Susan Standiford(Director)
Investment Manager is an AI-powered platform that converts property management reports into structured investment data for real estate portfolio management, enabling investors to validate, analyze, and gain insights from asset performance across their holdings.
AI & Machine LearningEnterprise SoftwarePropTech
DraftKings operates a multi-product gaming platform offering online sportsbooks, daily fantasy sports, and casino games to consumers across desktop, mobile apps, and retail locations.
FintechGamingMarketplacesSector AgnosticSports TechBoston, US
Woodrow Levin(Director)R. Thomas Dyal(Director)Paul Liberman(Executive Officer, Director)Ryan Moore(Director)Matthew Kalish(Executive Officer, Director)Jason Robins(Executive Officer, Director)
Followap provides mobile instant messaging infrastructure, including an Instant Messaging Service Center (IMSC) and an Interoperability Platform (ICP), for mobile network operators.
Enterprise SoftwareMedia & EntertainmentSaaS
Enables secure access to critical enterprise resources for distributed workforces including employees, partners, and contractors
Gusto provides payroll processing, employee benefits administration, and HR management tools to businesses, offering integrated software alongside support services for these functions.
Enterprise SoftwareHR TechSan Francisco, US
Josh Reeves(Founder/CEO)inEdward Kim(Founder/Empowering Gusto's Engineering Team)inTomer London(Founder/; Empowering Gusto's Product and Design Teams)in
humans& is a frontier AI lab focused on building human-centric AI systems that prioritize people and their relationships, emphasizing innovations in reinforcement learning, memory, and user understanding to create AI that strengthens organizations and communities.
AI & Machine LearningEnterprise SoftwareSaaSEl Segundo, US
Eric Zelikman(Co-founder)Alaarif Nooruldeen(Executive Officer, Director)Kristen Green(Director)Allen Mask(Director)Jonathan Ellman(Director)Eduardo Vivas(Director)
Inflection builds AI models that combine emotional and raw intelligence to create trustworthy AI agents for individuals and enterprises.
AI & Machine LearningPalo Alto, US
Karen Simonyan(Executive Officer, Director)
BoardReid Hoffman(Director)Mustafa Suleyman(Executive Officer, Director)
Jscrambler provides client-side application security, including polymorphic JavaScript code protection, software supply chain defense, and browser data governance to protect web applications against reverse-engineering, digital skimming, and third-party script vulnerabilities.
CybersecurityDeveloper ToolsEnterprise Software
Kopra Bio develops cancer immunotherapy technology that converts cancer cells into biofactories to produce their own destruction.
BiotechHealthtechMedical DevicesSan Francisco, US
Alexander Haddad(Founder)in
Mysten Labs builds infrastructure and tools for web3, focusing on making decentralized systems secure, reliable, and ready for mass adoption.
Cloud ComputingCrypto & Web3Deep TechDeveloper Tools
Adeniyi Abiodun(Founder)in
OhmConnect engages members to shift their electricity usage toward cleaner and cheaper times, helping them save money while supporting grid stability and renewable energy integration.
ConsumerEnergyIoTSaaSOakland, US
Ometria is a customer data and experience platform (CDXP) that provides AI-driven insights, customer segmentation, and a centralized marketing dashboard for retail brands.
Marketing TechRetail TechSaaS
Sensor Tower provides digital intelligence and analytics on mobile apps, games, web, and digital advertising, giving companies visibility into consumer behavior, usage, engagement, and competitor strategies.
AdTechData & InfrastructureMarketing TechSaaSSan Francisco, US
Snag is an online marketplace for finding and listing short-term apartment and room sublets, with listings across neighborhoods in cities such as New York.
ConsumerMarketplacesPropTech
Spekter Games develops and publishes Web2 games with passive Web3 reward layers on chat-based super apps such as Telegram and LINE, targeting mainstream gamers.
ConsumerCrypto & Web3Gaming
TK(Founder)
Taskade Genesis is a workspace platform that allows users to create live applications with integrated memory, intelligence, and execution capabilities through natural language prompts.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareFuture of WorkSaaSSan Francisco, US
Stan Chang(Founder)inJohn Xie(Founder)in
Virta Health offers a personalized nutrition program and digital health platform to help people reverse type 2 diabetes and obesity.
Digital HealthHealthtechSan Francisco, US
Exits · 1
IPOs and acquisitions across the tracked portfolioRubrickNYSE: RBRK
Portfolio news
latest coverage across their companiesRobinhood · techcrunch.com · Aug 5, 2026
Runway · mynorthwest.com · Jul 17, 2026
Inflection AI · entrepreneur.economictimes.indiatimes.com · Jul 17, 2026
DraftKings (NASDAQ:DKNG) · investing.com · Jul 10, 2026
Kopra Bio · endpoints.news · Jun 16, 2026
Gusto · gusto.com · Jun 2, 2026
Deep Infra · trysignalbase.com · May 4, 2026
Frequently asked questions
- What stage does Chamaeleon invest at?
- Chamaeleon invests at the Pre-Seed, Seed, Series A stages.
- What is Chamaeleon's typical check size?
- Chamaeleon typically writes checks of $1M – $5M.
- What sectors does Chamaeleon focus on?
- Chamaeleon focuses on AI & Machine Learning, Consumer, Enterprise Software, Fintech, Media & Entertainment, SaaS, Sector Agnostic.
- Where is Chamaeleon located?
- Chamaeleon is headquartered in Silicon Valley, US.
Images
Co-investors · 8
Fusion Fund is an early-stage venture capital firm backing startups with technical or data advantages in healthcare, enterprise AI, and industrial technology.
Floodgate is a venture capital fund that backs founders at the earliest stages, positioning itself as their first true believers.
DCVC (Data Collective) is a venture capital firm that backs founders building companies which apply technology to major challenges across areas such as energy, biotech, agriculture, and machine learning.
Basis Set Ventures is an AI-native venture firm that uses a modern machine learning stack and foundation models to find and support AI companies, positioning itself as a hands-on partner to founders.
Kicker Ventures invests in technology-driven healthcare companies developing novel solutions to health challenges, ranging from biosignal detection and data science to AI-driven personalized engagement.
Bain Capital Ventures is the venture arm of Bain Capital, backing founders from incubation and seed through growth-stage, leveraging Bain Capital's global platform, industry expertise, and network.
Village Global is a venture capital firm backed by a network of 400+ founders, operator angels, and prominent LPs from leading tech companies, offering founders access to its network alongside capital.
Acrobator Ventures is a seed-stage venture capital firm based in Amsterdam that invests in software companies founded by entrepreneurs from the CIS, Central and Eastern Europe, and Baltic regions. The firm focuses on data infrastructure, fintech, biotech, cybersecurity, robotics, and related enabling technologies.
Firms observed investing alongside Chamaeleon, from public investor directories. Shared companies are the overlap with Chamaeleon's recorded portfolio.
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