APERTURE Venture Partners — Full Portfolio

Collegium Pharmaceutical is a biopharmaceutical company developing a portfolio of medications to treat serious medical conditions.

BiotechCanton, US

MHMichael Heffernan(Executive Officer, Director)inPBPaul Brannelly(Executive Officer)inVKVikram Karnani(President and Chief Executive Officer, and Director)in

BoardEran Nadav(Director)John Freund(Director)PHPatrick Heron(Director)in

Co-investorsECEcoR1 CapitalFRFrazier Life SciencesLOLongitude CapitalBOBoston Millennia PartnersRARA Capital

Shoulder Innovations develops InSet® glenoid technology for shoulder joint implants that reduce the rocking horse effect and provide mechanical stability, serving patients with severe shoulder arthritis.

HardwareHealthtechMedical DevicesNorthern California, US

RBRobert Ball(CEO & Executive Chairman)MAMatthew Ahearn(Chief Operating Officer)inJPJeff Points(Executive Officer)inDon Running(Manager and Chief Executive Officer)Jeff Ondrla(Chief Technology Officer)DLDavid L. Blue(Chief Customer Experience Officer)in

Co-investorsALAlumni VenturesARArboretum VenturesGEGenesis Innovation GroupGLGlobal BrainINInvest MichiganLILightstone Ventures+3 more

Tarsus is a biopharmaceutical company focused on developing and delivering medicines that target the root cause of serious diseases with high unmet need, including eye conditions.

BiotechHealthtechMedical Devices

BABobak Azamian(Founder)inJeffrey Farrow(Chief Financial Officer and Chief Strategy Officer)Seshadri Neervannan(Chief Operating Officer)AMAziz Mottiwala(Chief Commercial Officer)inDWDianne Whitfield(Chief Human Resources Officer)inEYElizabeth Yeu-Lin(Chief Medical Officer)

Co-investorsFLFlying L PartnersFRFrazier Life SciencesVIVisionary VenturesVIVivo CapitalBABain Capital Life SciencesRTRTW Investments L.P.

Trevi Therapeutics is a clinical-stage biopharmaceutical company developing Haduvio (oral nalbuphine ER), an investigational therapy for chronic cough that targets the central and peripheral cough reflex arc.

BiotechHealthtechNew Haven, US

Thomas Sciascia(Executive Officer)JGJennifer Good(Co-Founder, President and CEO)inTSThomas Sciascia, M.D.(Co-Founder, Chief Scientific Officer)LDLisa Delfini(Executive Officer)inWFWilliam Forbes(Executive Officer)inMichael Heffernan(Director)in

Co-investorsFRFrazier Life SciencesNENew Enterprise Associates (NEA)PIPivotal Life SciencesVIViking GlobalOMOmega Funds

VS3 Medical is a medical device company developing the VS3 Medical Stent System, an investigational neurovascular implant designed to treat symptomatic venous sinus stenosis within the dural venous sinus anatomy.

HardwareHealthtechMedical Devices

Co-investorsGIGilde HealthcareUSUS Venture Partners

Avedro is an ophthalmic company focused on corneal health, known for bio-activated cross-linking therapies such as the KXL system and riboflavin-based treatments used to address progressive keratoconus.

BiotechHealthtechMedical DevicesWaltham, US

David F. Muller(Executive Officer, Director)inBJBrian J. Roberts(Executive Officer)inRJRhonda J. Bracey(Executive Officer)inThomas W. Burns(Chairman & Chief Executive Officer)

BoardJason Hong(Director)JDJeff Dykan(Director)in

Co-investorsLALAVLILilly Asia VenturesSCSCP Vitalife PartnersTHThird Point VenturesWEWestern Technology InvestmentABAbingworth+5 more

Axonics Modulation, now part of Boston Scientific, develops medical devices in the field of neuromodulation therapies for patients.

HealthtechMedical Devices

RCRaymond Cohenin

Co-investorsLOLongitude CapitalADAdvent Life SciencesGIGilde HealthcareNENeomed Management

BardyDx develops the Carnation Ambulatory Monitor (CAM), a lightweight cardiac patch monitor designed for extended-wear ambulatory ECG monitoring that emphasizes P-wave signal clarity.

Digital HealthHealthtechMedical DevicesSeattle, US

Gust H. Bardy(Executive Officer, Director, Promoter)Mark Querry(Executive Officer)Kevin Nelson, III(Executive Officer)Rik Vandevenne(Director)Alan Levy(Director)Mark Handfelt(Executive Officer, Promoter)

Co-investorsAPAphelion CapitalASAscension VenturesLULumira VenturesRCRC CapitalRERex Health VenturesSVSV Health Investors+2 more

Biohaven is a biopharmaceutical company that discovers, develops, and commercializes treatments across immunology, obesity, neuroscience, and oncology, targeting rare and common diseases with limited treatment options.

BiotechHealthtech

VCVlad Coric(Chairman & Chief Executive Officer)in

Co-investorsAIAisling CapitalCOConnecticut InnovationsOUOUP (Osage University Partners)HBHBM Healthcare InvestmentsOROrbiMed

Cardiac Dimensions develops medical technology to treat heart failure caused by functional mitral regurgitation (FMR), aiming to address underlying causes rather than symptoms.

BiotechHealthtechMedical DevicesKirkland, US

Frederick A. Stewart(Executive Officer, Director)RWRick Wypych(Executive Officer)in

BoardKurt Wheeler(Director)Nathan Every(Director)Douglas C. Fisher(Director)GBGerry Brunk(Director)in

Co-investorsLULumira VenturesRERedbus VenturesALAlly Bridge GroupCLClaret Capital PartnersJEJefferiesM.M.H. Carnegie & Co.

Exit: Acquired by St.

Jay Yadav MD(Founder)in

Co-investorsARArboretum VenturesSASaints Capital

HealthtechEmeryville, US

Bill Malecki(Executive Officer)Daniel Burnett(Director)Ulric Cote(Executive Officer, Director)

BoardDr. Jason Hong(Director)ANAnthony Natale(Director)inCarter Mayer(Director)

Co-investorsGRGreen Park & Golf VenturesSCScientific Health DevelopmentTHThird Point VenturesLOLongwood FundVHVHM

Cortica provides in-home, in-clinic, and telehealth neurological therapies for children with autism and developmental differences, integrating neurological, biomedical, behavioral, speech-language, and sensorimotor treatments.

Digital HealthHealthtechMedical DevicesSan Diego, US

DSDr. Suzanne Goh(Founder)NHNeil Hattangadi(Founder)inBEBriana Elvaiah(Executive Officer)inSuzanne Goh-Hattangadi(Founder)

BoardRDRyan Drant(Director)inStephen Anastos(Director)

Co-investors.4.406 VenturesAIAIFCVCVS Health VenturesECEcho Health VenturesLOLongitude CapitalOPOptum Ventures+6 more

Devoro Medical developed the WOLF Thrombectomy Platform, a non-console, lytic-free medical device that uses finger-like prongs to capture and remove blood clots (thrombi) from the arterial and venous systems.

HardwareHealthtechMedical DevicesFremont, US

BoardEEErik Engelson(Director)Michael Wallace(Executive Officer, Director)Skott Greenhalgh(Director)

Co-investorsSHShangBay Capital LLCNONorwest Venture Partners

Endotronix develops the Cordella PA Sensor and Heart Failure System, an FDA-approved implantable pulmonary artery pressure sensor and remote monitoring platform for managing patients with NYHA class III heart failure.

Digital HealthHealthtechMedical DevicesWoodridge, US

HRHarry Rowland(Executive Officer, Director)inANAnthony Nunez(Founder)in

BoardJonathan Jonas(Director)Raymond S. Barrett, Jr.(Director)Sam R. Leno(Director)Leslie A. Saxon(Director)

Co-investorsBIBioventures InvestorsJUJumpstart VenturesLULumira VenturesOSOSF VenturesSESeroba Life SciencesSVSV Health Investors+1 more

Designs and manufactures instruments and devices for sinus surgery; acquired by Smith & Nephew in 2013.

Co-investorsTATargeted Technology Funds

Inspire Medical Systems develops an FDA-approved implantable device that treats obstructive sleep apnea (OSA) by working with the patient's natural breathing, controlled via a small remote and intended for patients for whom CPAP is not effective.

Digital HealthHealthtechMedical DevicesGolden Valley, US

THTim Herbert(Founder)in

BoardMudit Jain(Director)JEJoyce Erony(Director)inDana Mead(Director)CKChau Khuong(Director)inCTCasey Tansey(Director)

Co-investorsAMAmzak HealthUSUS Venture PartnersOROrbiMed

Developed a robotic surgical arm for knee and hip arthroplasty; acquired by Stryker for $1.65B in 2013.

Co-investorsLULumira VenturesMOMontreux Equity Partners

Miach Orthopaedics develops implants that help the body restore its own connective tissue, with an initial focus on treating ACL tears.

HealthtechMedical DevicesWestborough, US

MMMartha Murray(Founder)inCJChris Joyce(Executive Officer)inPMPatrick McBrayer(Executive Officer, Director)inSean Sansiveri(Director)Pieter Wolters(Director)

BoardMarc-Andre Marcotte(Director)

Co-investorsAMAmzak HealthENEndeavour VisionSVSV Health Investors

Nalu Medical develops a non-integrated neurostimulation system that uses electrical impulses to interrupt pain signals for patients with intractable chronic nerve pain.

HardwareHealthtechMedical DevicesCarlsbad, US

EFEarl Fender(President & CEO)inLHLee Hartley(Executive Officer)inAllen Meacham(Executive Officer)inBSBick Sellers(Executive Officer)inTAThomas A. West(Executive Officer, Director)inJeffrey Swiecki(Executive Officer)

Co-investorsB B Capital GroupB4B4 CapitalDEDecheng CapitalENEndeavour VisionLOLongitude CapitalMVMVM Life Science Partners+3 more

Neuros Medical develops the Altius Direct Electrical Nerve Stimulation System, an FDA-approved implantable device that delivers patient-controlled electrical stimulation to treat chronic post-amputation pain in adult lower limb amputees.

BiotechHealthtechMedical DevicesAliso Viejo, US

David Veino(President and CEO)Zach Stassen(Chief Financial Officer)Robert J. Centa(Chief Financial Officer)JJJon J. Snyder(Director, President, Secretary and CEO)in

BoardJEJoyce Erony(Director)inWHWilliam Harrington(Director)in

Co-investorsAMAmzak HealthCWCWRU Technology VenturesISiSelect FundJOJobsOhio VenturesJUJumpstart VenturesRIRiverVest Venture Partners+5 more

NuXcel is a global medical device accelerator that founds and incubates bioelectronics and neuromodulation startups addressing large unmet clinical needs, using a lean innovation model.

Deep TechHealthtechMedical Devices

Co-investorsTRTreo Ventures, LlcAMAmzak HealthNONorwest Venture PartnersOSOSF VenturesU.U.S. Venture Partners

Developer ToolsE-commerceSaaS

ShiraTronics is a medical device company developing an implantable device to treat chronic migraine disease.

BiotechHardwareHealthtechMedical DevicesBrooklyn Park, US

Robert Binney(Executive Officer, Director)

BoardJEJoyce Erony(Director)inZSZack Scott(Director)inBVBrad Vale(Director)inCTCasey Tansey(Director)MJMudit Jain(Executive Officer, Director)in

Co-investorsAMAmzak HealthBRBreakout VenturesGLGlobal BioAccess FundNONorwest Venture PartnersOSOSF VenturesSESeroba Life Sciences+3 more

SoundBlade Medical develops handheld histotripsy technology for non-invasive surgery, using focused ultrasound to treat tissue with precision.

HardwareHealthtechMedical Devices

JBJeremy Brown(Co-Founder & CTO)inMMMatt Mallay(Co-Founder & Sr. Dir. R&D)inABAndre Bezanson(Co-Founder & Dir. R&D)inEVEli Vlaisavljevich(Co-Founder)inRBRick Balys(Co-Founder)inNBNeil Barman(Chief Executive Officer)in

Co-investorsAMAmzak HealthLULumira VenturesINInvest Nova Scotia

Menlo Park, US

DRDuke Rohlen(Chief Executive Officer)

BoardCamille Samuels(Director)ANAnthony Natale(Director)inReed Gaither(Director)AKAftab Kherani(Director)Ron Kuppersmith(Director)

Co-investorsAIAisling CapitalCOCorrelation VenturesVEVenrockWEWestern Technology InvestmentHEHealthQuest Capital

HealthtechLexington, US

Michael Cima, Ph.D.(Director)RDRahul Dhanda(Senior Vice President, Corporate Development)inJMJohn McDonough(Chief Executive Officer)inTom Lowery, Ph.D.(Chief Scientific Officer)Michael Gibbs, Esq.(Vice President and General Counsel)Joanne Spadoro, Ph.D.(Chief Operating Officer)in

Co-investorsAIAisling CapitalINIn-Q-TelARArcus VenturesFLFlagship VenturesFLFlybridge Capital PartnersJOJohnson & Johnson Innovation – JJDC+2 more

uLab Systems builds digital orthodontics tools, including software (uDesign, uAssist) and uSmile clear aligners manufactured in the USA, for dental professionals and orthodontic practices.

BiotechDigital HealthHealthtechMedical DevicesSaaSMemphis, US

AmirAli Talasaz(Director)Mark Foley(Director)David Thrower(Executive Officer)Tim Dumore(Director)Rita O'Connor(Director)Robert Doty(Executive Officer)

Co-investors7 7 Gate VenturesCICivilization Ventures Management, LlcTATachles VC

V-Wave Medical develops a percutaneous implantable shunt device for treating chronic heart failure patients.

BiotechHealthtechMedical DevicesIsrael, IL

Co-investorsBRBRM CapitalPOPontifax Venture CapitalTRTriventures

Venus develops non-invasive, energy-based medical aesthetic devices for body, face, skin, and hair treatments, integrating robotics, AI, and IoT technologies.

BiotechHardwareHealthtechMedical DevicesToronto, US

DSDomenic Serafino(Executive Officer, Director)inKGKirk Gunhus(Executive Officer)inRPRoss Portaro(Executive Officer)inAGAnna Georgiadis(Executive Officer)inMKMelissa Kang(Executive Officer)inMMMichael Mandarello(Executive Officer)in

Co-investorsESEssex Woodlands Healthcare PartnersLOLongitude CapitalCLClarus VenturesHEHealthQuest Capital

Verix Health develops a platform of steerable surgical devices designed to reach and target cancer in hard-to-access areas of the body, intended for interventional oncologists and their patients.

BiotechDeep TechHealthtechMedical DevicesPhiladelphia, US

DKDoug Koo(Mr. Koo is the Chief Financial Officer of the Issuer.)inMichael Dishowitz(Mr. Dishowitz is the Secretary and Treasurer of the Issuer.)TNTony Natale(Director)inSasha Schrode(Executive Officer, Director, Promoter)

BoardAKAftab Kherani(Director)inDRDuke Rohlen(Director)in

Co-investorsWEWestern Technology InvestmentAJAjax Health

XII Medical develops neuromodulation therapies for treating obstructive sleep apnea, focusing on simplifying treatment options and improving patient outcomes.

Deep TechDigital HealthHealthtechMedical DevicesUnion City, US

Garrett Schwab(Chief Executive Officer)inSKShane Kreidel(Secretary and Chief Financial Officer)inZachary Eisen(Director)

BoardDRDuke Rohlen(Director)inJD Friedland(Director)Saoussen Ben Halima(Director)

Co-investorsBRBroadview VenturesCICincyTechINIntuitive VenturesJOJobsOhio VenturesAJAjax HealthOMOmega Funds

HealthtechMountain View, US

KBKenneth Binmoeller, M.D.(Executive Officer, Director)inGreg Patterson(Executive Officer, Director)

BoardA. Barr Dolan(Director)Eric Sillman(Director)Anthony Natale, M.D.(Director)Avi Kometz(Director)

Co-investorsATATEL VenturesTHThird Point VenturesASAscent Biomedical VenturesDEDeerfield Management CompanyTHThird PointWEWestern Technology Investment