Sixty Degree Capital — Full Portfolio

Helicons develops a peptide-based therapeutic platform designed to target intracellular proteins previously considered undruggable by combining the specificity of antibodies with the cell-penetrating properties of small molecules.

AI & Machine LearningBiotechDeep TechMedical Devices

Mathai Mammen(CEO, President and Chairman)in

Co-investorsARCH Venture PartnersCatalio Capital Management, LPForesite CapitalFrazier Life SciencesGeneral CatalystNextech Invest+5 more

Bionyra Pharma is a clinical-stage biopharmaceutical company developing next-generation mono and multispecific antibodies for severe immune-mediated inflammatory diseases, with an initial focus on atopic dermatitis and inflammatory bowel disease.

BiotechHealthtech

Frédéric Marrache(Co-founder & CEO)in

Co-investorsJeito CapitalSanofi VenturesSofinnova PartnersVIVES PartnersApollo Health Ventures

Clinical-stage gene therapy company developing AAV therapeutics for inherited retinal disorders.

Co-investorsLongwood FundXGEN Venture

Clinical-stage biotech developing dual-acting biologics for sustainable weight loss and maintenance.

Arcellx develops CAR T-cell therapies that are individually designed for each patient, using the immune system to target and attack cancer.

BiotechHealthtechGaithersburg, US

Han Lee(Executive Officer)Rami Elghandour(Executive Officer, Director)

BoardJill Carroll(Director)inAli Behbahani(Director)inDerek Yoon(Director)inTiba Aynechi(Director)in

Co-investorsLG Technology VenturesNew Enterprise Associates (NEA)Quan CapitalSamsara BioCapitalSolasta VenturesSR One Capital Management+2 more

Cato Networks provides a cloud-native SASE platform that converges networking, zero-trust security, and access into a single global service for enterprises.

Cloud ComputingCybersecurityEnterprise SoftwareTel Aviv, IL

Shlomo Kramer(Co-Founder and CEO)inGur Shatz(Co-Founder and Board Member)Tomer Wald(Chief Financial Officer)Alon Alter(Chief Business Officer)Zehorit Mulshanski(Chief People Officer)Eyal Heiman(Chief Technology Officer)

Co-investorsAcrew CapitalAdams Street PartnersArcher Capital GroupArcher Venture CapitalAspect VenturesBallistic Ventures+8 more

Clinical-stage biotech developing TCR-mimetics recognizing intracellular tumor antigens for hematological and solid cancers.

DataGrail provides a software platform that helps companies build and scale comprehensive privacy programs to manage personal data across multiple systems.

AI & Machine LearningCybersecurityData & InfrastructureEnterprise SoftwareSaaS

Daniel Barber(CEO & Co-Founder)inIgnacio Zendejas(Co-Founder)in

Co-investorsFelicis VenturesOperator CollectiveThird Point VenturesThomson Reuters VenturesBasis Set VenturesDig Ventures Management Limited+2 more

Eclypsium provides hardware and firmware security solutions for enterprises to identify and address vulnerabilities in chips, low-level code, and digital supply chains.

CybersecurityDefense TechEnterprise SoftwareHardwarePortland, US

Yuriy Bulygin(Co-founder)inAlex Bazhaniuk(Co-founder)Alex B(Founder)John Ewert(Executive Officer)in

BoardAlex Doll(Director)inTimothy Porter(Director)in

Co-investorsAlumni VenturesAndreessen HorowitzAV8 VenturesaVentureBasecamp FundDnipro+13 more

Chicago, US

Edward Bellis(Executive Officer, Director)Michael Roytman(Director)inJason Jacobs(Executive Officer)Stephen Ward(Director)

BoardJohn Cowgill(Director)in

Co-investorsCostanoa VenturesHyde Park Angels

Oncology-focused pharmaceutical company developing first-in-class nuclear export inhibitors for cancer treatment.

GlycoEra develops glycan-based therapeutics, applying glycoengineering technology to create biologic drugs.

BiotechHealthtechNewton, US

Ganesh V. Kaundinya(President & CEO)in

Co-investors5AM VenturesCatalio Capital Management, LPLifeArc VenturesRoche Venture FundSofinnova PartnersAgent Capital+1 more

Kinaset Therapeutics is a drug developer working on KN-002, a therapeutic candidate for treating severe asthma across patients regardless of the underlying cause of inflammation.

BiotechHealthtechMedfield, US

Roger Heerman(Chief Business/Operating Officer / Co-Founder)inFrazer Morgan(Chief Development Officer / Co-Founder)Robert Clarke(Chief Executive Officer / Board Member / Co-Founder)Christopher O’Brien(Chief Medical Officer)

BoardJamil Beg(Director of the Issuer)inTom King(Director of the Issuer)

Co-investors5AM VenturesAtlas VentureRA CapitalEQT Life SciencesVivo CapitalGimv+1 more

KnownWell provides virtual and in-person weight-inclusive healthcare for patients with overweight and obesity.

Digital HealthHealthtechWellness & FitnessNeedham, US

Ben Wanamaker(Director)Angela Fitch(Executive Officer)inBrooke Boyarsky Pratt(Executive Officer, Director)in

BoardVineeta Agarwala(Director)inIan Chiang(Director)in

Co-investorsAndreessen HorowitzCVS Health VenturesFlare Capital Partners

Digital asset exchange platform offering trading, derivatives, and institutional services with strong security and regulatory compliance.

Marathon Health provides an advanced primary care model to employers through onsite, nearsite, network, and virtual health centers, aiming to improve employee health and lower healthcare costs.

Digital HealthHealthtechWellness & Fitness

Co-investorsGeneral AtlanticOak HC/FT

Nested Therapeutics is a precision oncology company developing small-molecule cancer therapeutics by identifying overlooked driver mutations and novel binding pockets through a drug discovery platform combining genomics, computational biophysics, machine learning, and chemical biology.

AI & Machine LearningBiotechHealthtech

Arvin Dar(Co-founder & Board Observer)inKevan Shokat(Scientific Co-founder)Klaus Hoeflich(Co-founder & former Chief Scientific Officer)inDarrin Miles(Chief Executive Officer)Philip Komarnitsky(Chief Medical Officer)inTanja Weber(Chief Business Officer)

Co-investorsVersant VenturesForesite CapitalCowen Healthcare InvestmentsGoldman Sachs

NextPoint is a precision therapeutics company developing cancer treatments targeting the B7-H7/HHLA2 axis, including a T-cell engager, an antibody-drug conjugate with proprietary linker technology, and a multi-functional checkpoint inhibitor.

BiotechHealthtechAustin, US

Gordon Freeman(Scientific Founder)XingXing Zang(Scientific Founder)inIvan Cheung(Chief Executive Officer)inLeena Gandhi(Chief Medical Officer)inTatiana Novobrantseva(Chief Scientific Officer)inAxel Hoos(Director)

Co-investorsCatalio Capital Management, LPMPM BioImpactSanofi VenturesCatalio Capital ManagementInvusLeaps by Bayer

PandasAI is an open-source library that lets users query data stored in dataframes, databases, or data lakes using natural language to perform analysis and generate visualizations without writing code.

AI & Machine LearningData & InfrastructureEnterprise SoftwareMunich, DE

Gabriele Venturi(Founder)in

Co-investorsEpisode1Runa CapitalY CombinatorVento

Rafay builds infrastructure orchestration and workflow automation software for self-service compute consumption across GPU and CPU environments.

AI & Machine LearningCloud ComputingDeveloper ToolsEnterprise Software

Co-investorsFloodgateForgePoint CapitalMoment Ventures, LlcNTT DOCOMO VenturesRidge Ventures

RedRidge Bio discovers and develops biparatopic antibodies (antibodies that bind two sites on a single protein), including biparatopic antibody-drug conjugates, as therapeutics for oncology and autoimmune diseases.

BiotechHealthtech

Bill Sellers(Scientific Founder and Director Cancer Program, Broad Institute)Stephen Yoder(President & CEO)

Co-investorsNew Enterprise Associates (NEA)Versant Ventures

Biotech company developing next-generation non-viral gene delivery systems.

Space exploration and technology company developing rockets and spacecraft for human spaceflight and satellite deployment.

T-knife develops engineered T cell therapies designed to treat patients with solid tumors, using proprietary platforms and synthetic biology to enhance T cells.

BiotechHealthtech

Elisa Kieback(Founder)in

Co-investorsAndera PartnersRA CapitalVersant VenturesFidelity Investments

Marwan Forzley(Founder)in

Co-investorsBY Venture PartnersDASH VenturesDigital Currency GroupElectric Feel Ventures LlcKleiner PerkinsNyca+3 more