/Companies

Nested Therapeutics

Founded 2021 · 16 employees on LinkedIn · 6 known investors

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Nested Therapeutics is a precision oncology company developing small-molecule cancer therapeutics by identifying overlooked driver mutations and novel binding pockets through a drug discovery platform combining genomics, computational biophysics, machine learning, and chemical biology. Its lead program, NST-628, is a brain-penetrant pan-RAF/MEK molecular glue in Phase 1 trials for MAPK-driven solid tumors, alongside a mutation-selective p53-pathway program.

Founders & leadership

Nested Therapeutics was founded in 2021 by Arvin Dar, Kevan Shokat, and Klaus Hoeflich.

ADArvin Dar
Arvin DarCo-founder & Board Observer
KS
Kevan ShokatScientific Co-founder
KHKlaus Hoeflich
Klaus HoeflichCo-founder & former Chief Scientific OfficerCo-founder and former Chief Scientific Officer of Nested Therapeutics, a precision oncology company. Hoeflich has advanced cancer drug candidates through target discovery, IND submission, and clinical development, with experience in R&D leadership and establishing academic and industry partnerships.
DMDarrin Miles
Darrin MilesChief Executive Officer
PKPhilip Komarnitsky
Philip KomarnitskyChief Medical OfficerPhilip Komarnitsky is Chief Medical Officer at Nested Therapeutics, a precision oncology company developing small-molecule cancer therapeutics. His background includes expertise in clinical and pre-clinical drug development, as well as product licensing due diligence.
TWTanja Weber
Tanja WeberChief Business Officer

Investors · 6

Funding

SEC filings, press & company announcements

Source: company announcements and press reports — follow each round's link for the claim.

Frequently asked questions

What does Nested Therapeutics do?
Nested Therapeutics is a precision oncology company developing small-molecule cancer therapeutics by identifying overlooked driver mutations and novel binding pockets through a drug discovery platform combining genomics, computational biophysics, machine learning, and chemical biology. Its lead program, NST-628, is a brain-penetrant pan-RAF/MEK molecular glue in Phase 1 trials for MAPK-driven solid tumors, alongside a mutation-selective p53-pathway program.
Who founded Nested Therapeutics?
Nested Therapeutics was founded by Arvin Dar, Kevan Shokat, Klaus Hoeflich in 2021.
Who are Nested Therapeutics's investors?
Nested Therapeutics's investors include Versant Ventures, Foresite Capital, Sixty Degree Capital, Cowen Healthcare Investments, Goldman Sachs, Section 32.