National Science Foundation — Full Portfolio

Fria makes cooling jewelry using patented hydro-powered technology to provide relief from hot flashes associated with menopause.

ConsumerFemTechHardwareWellness & Fitness

Frontier Bio develops tissue engineering and bioprinting technology, including fabrication of tissue-engineered blood vessels for clinical and in vitro applications.

BiotechDeep TechMedical Devices

EBEric Bennett(CEO)inSPSam Pashneh-Tala(CTO)in

BoardGCGeorge Church(Scientific Advisor)

Co-investorsARArtesianASAsymmetry VenturesBOBoutique Venture PartnersBRBrincPOPortfoliaSTStartX

PureBioX uses AI-driven volatile organic compound (VOC) profiling to turn chemical emissions into predictive insights, with products for DNA collection, extraction and purification, rapid microbial detection, and a VOCScan software platform.

AI & Machine LearningBiotechFoodTech

BigHat Biosciences develops antibody therapies using machine learning and synthetic biology through its Milliner platform, which combines a high-speed wet lab with machine learning for antibody discovery and engineering.

AI & Machine LearningBiotechDeep TechSan Francisco, US

FruitVaccine develops fruit-based vaccines administered mucosally through oral drops or dried fruit pills rather than needles, targeting mucosal infections such as respiratory diseases.

AgTechBiotechFoodTechHealthtechImpact & Social GoodUrbana, US

S. Indu Rupassara(Co-Founder/President/CEO)inDennis E. Buetow(Co-Founder/Founding President)S. Indu Rupassara, PhD, MBA(Co-Founder/President/CEO)inDennis E. Buetow, PhD(Co-Founder/Founding President)

FTL Labs performs research and development across advanced technology fields including robotics, optics, acoustics, life sciences, and custom software solutions.

Deep TechEnterprise SoftwareHardwareMassachusetts, US

Dr. Michael White(CTO)

Fusion Coolant Systems makes Pure-Cut, a machine-tool cooling and lubrication system that uses supercritical carbon dioxide instead of traditional cutting fluids to extend tool life, improve surface finish, and reduce health and environmental risks in CNC machining.

Advanced ManufacturingCleantechHardware

SSSteve Skerlos(Founder & Chief Technology Officer)in

Co-investorsIDID VenturesINInvest MichiganMAMaterial ImpactMIMichigan Rise

FSB develops semiconductor substrate manufacturing technology using GaN and graphene-assisted processes to reduce costs and improve quality for III-V material devices.

Deep TechNew MaterialsSemiconductors

futuresTHRIVE builds AI-based digital mental health screening tools for children and adolescents, collecting early data on factors such as adverse childhood experiences, anxiety, depression, and suicidality.

AI & Machine LearningDigital HealthHealthtechMental Health

WWWendy Ward(Founder)inWBWendy B Ward(Founder)inTBTracy Beeson(Lead Technical Advisor, CTO)in

Co-investorsCOConnecticut Innovations

Fyodor Biosciences develops innovative diagnostics, medicines, and healthcare solutions with a focus on accessible global health.

BiotechDigital HealthHealthtechMedical Devices

Dr. Eddy Agbo(Founder & CEO)

Co-investors50500 Global

BiotechMissoula, US

BCBrian Conway(Executive Officer)inChristopher Booth(Executive Officer, Director)Sarjubhai Patel(Executive Officer, Director)

BoardMGMichael Goguen(Director)inASAvery Sonnenberg(Director)in

Co-investorsTWTwo Bear Capital

Co-investorsBLBlue Startups

Gaia AI provides AI-powered tools and sensor-based data collection (a wearable backpack and mobile/web apps) for forest inventory and analysis, delivering biometric insights to optimize harvesting, timber sales, and carbon credit strategies.

AgTechAI & Machine LearningClimate Tech

Co-investorsMIMilemark Capital PartnersSOSOSVTHThe E14 FundUBUbiquity Ventures

A platform that makes high-quality digital learning tools freely accessible to underserved children to help close the learning equity gap.

EdTechImpact & Social GoodNew York City, US

Michelle Miller(Co-Founder and CEO)inSadaf Sajwani(Co-Founder and COO)in

General Engineering and Research develops and manufactures specialty materials and devices, including functionalized silica nanoparticles, magnetocaloric materials, and thermoelectric components.

Advanced ManufacturingDeep TechHardwareNew Materials

Dr. Robin V. Ihnfeldt(CEO/Owner)

GelSight develops high-resolution tactile imaging and surface metrology technology for measuring and analyzing surface properties in manufacturing.

Advanced ManufacturingAI & Machine LearningDeep TechHardwareWaltham, US

Micah K Johnson(Executive Officer, Director)Edward Adelson(Director)Kimo Johnson(Co-Founder & Chief Science Officer)inJanos Rohaly(Co-Founder & Chief Technology Officer)inWilliam J. Yost(Executive Officer, Director)YBYoussef Benmokhtar(Chief Executive Officer)in

Co-investorsANAnzu PartnersSCScout VenturesSCScout VenturesOMOmega Funds

Co-investorsDODorm RoomTHThe E14 Fund

Cincinnati, US

Joseph Edward Sprengard(Executive Officer, Director)Vesselin Shanov(Executive Officer, Director)Mark Schulz(Executive Officer, Director)

BoardJeb Head(Director)William Noack(Director)

Austin, US

HJHardik Jain(Executive Officer, Director)inSVSriram Vishwanath(Executive Officer, Director)Stephen Gartside(Executive Officer, Director)

Co-investorsUTUT Horizon FundAZAzure Capital PartnersBABandgap VenturesBMBMW i VenturesINIntel Capital

Geopipe creates digital twin technology that generates immersive 3D models of real-world cities and environments for use in games, simulations, training, and architecture.

AI & Machine LearningData & InfrastructureDeep TechGamingNew York City, US

CMChristopher Mitchell(CEO and Co-Founder)inTDThomas Dickerson(CSO and Co-Founder)inDickerson Dickerson(Executive Officer, Director, Promoter)Thomas Dickerson, Ph.D(CSO and Co-Founder)Joshua Duyan(Director)

Co-investorsGEGENIUS NYGRGreat Oaks Venture CapitalTETechstarsVEVermont Center for Emerging Technologies (VCET)ALAlexa FundAMAME Cloud Ventures+2 more

Ghamut is a technology and strategy consultancy that works with clients to identify strategic opportunities and build data- and technology-driven solutions.

Data & InfrastructureEnterprise SoftwareImpact & Social Good

Secure Open Solutions provides cybersecurity compliance services for defense contractors and small businesses, helping them meet NIST SP 800-171, CMMC, and ITAR requirements.

CybersecurityDefense TechGovTech

GigaGen, a subsidiary of Grifols, develops recombinant polyclonal and monoclonal antibody therapies for immunodeficiencies, infectious diseases, transplant rejection, and cancer using single-cell discovery technologies.

BiotechDeep TechSouth San Francisco, US

DJDavid Johnson(Executive Officer, Director)inChuck Wilson(Director)CKCarter Keller(Director)

Pasadena, US

Jiaju Ma(Executive Officer, Director)SMSaleh Masoodian(Executive Officer, Director)inEric R Fossum(Founder)Barmak Masoodian(Director)Susan Fossum(Director)

Giner Labs is a research and development center focused on electrochemical technologies, including electrochemical sensors, electrolyzers, fuel cells, advanced materials, and medical devices.

Deep TechEnergyMedical Devices

Glint, a brand by Luminii, makes specification-grade architectural lighting including the HERO luminaire family, whose patented LightShift technology adjusts light direction without moving the fixture.

Advanced ManufacturingHardware

Global Aerospace Corporation provides research, development, and consulting services for aerospace systems and missions, with specialization in solutions for harsh environments including buoyant and hypersonic systems, as well as deep ocean systems research for government and commercial customers.

Deep TechDefense TechHardwareSpace TechNot stated, US

Kerry T. Nock(Founder, President, Chairman of the Board of Directors)

GCTG is a consulting firm providing technical and business development expertise to assist organizations with technology strategy and engineering management.

CleantechDeep TechDeveloper ToolsEnergyEnterprise SoftwareHardwarePhoenix, US

Global Bioinc is a biotechnology company that discovers and develops therapeutic antibodies for oncology, immunology, and infectious disease applications.

BiotechDeep TechMedical Devices

Globe Biomedical develops medical-grade sensing embedded into eyewear, with its first product, Blink® Frames, capturing physiological and environmental metrics (such as intraocular pressure, blink dynamics, and tear film stability) to address myopia and support biomarker discovery.

Digital HealthHardwareMedical Devices

Joshua Park(Co-Founder, Chief Executive Officer)Matthew Rickard(Co-Founder, Chairman of the Board)Creed Jones(Co-Founder, Chief Technology Officer)Dr. Rehan Ahmed(Co-Founder, Chief Medical Officer)

GlucoSentient develops diagnostic assays based on functional DNA (DNAzymes and aptamers) and nanomaterials for sensing applications.

BiotechDigital HealthMedical Devices

Yi Lu(Founder & Scientific Advisor)Tian Lan(Technical Lead)Steve Mayer

Co-investorsSESerra Ventures

GlycoSurf produces high-purity (>95%) bio-inspired glycolipid and rhamnolipid surfactants using a green chemistry synthetic process, with sugar head-groups including glucose, galactose, and xylose and customizable chain lengths.

BiotechCleantechNew Materials

Glyscend Therapeutics is a clinical-stage biopharmaceutical company developing oral, first-in-class therapies for type 2 diabetes and obesity.

BiotechDeep TechDigital HealthHealthtechLongevityBaltimore, US

Ashish Nimgaonkar(Executive Officer, Director)DMDennis McWilliams(Director)inCasey Cunningham(Director)Leighton Read(Director)inBSBob Soh(Director)in

Co-investorsBRBrandon BioCatalystBRBrandon Capital PartnersBRBreakout Labs

GMJ Techs develops analytical instruments that combine capillary electrophoresis with optical and mass spectrometry detection for bioanalytical applications.

BiotechDeep TechHardwareMedical DevicesSeattle, US

Carol Berry(CEO)Tosin Dada(President & CTO)

gNu Technologies develops technology aimed at improving injection/puncture systems to address technical limitations in drug delivery, targeting applications such as autoinjectors, safety syringes, and specialized needles.

BiotechHealthtechMedical Devices

goTenna builds mesh networking hardware and software for off-grid connectivity in mission-critical operations.

Defense TechHardwareIoTBrooklyn, US

Daniela Perdomo(Founder)Jorge Perdomo(Founder)

BoardLMLarry Marcus(Director)John Levy(Director)

Co-investors3S3Spoke CapitalALAlso CapitalBLBloomberg BetaCACadron Capital PartnersCOCollaborative FundCOComcast Ventures+16 more

Gradescope is a web platform for administering and grading assessments—paper-based, digital, code, and bubble-sheet assignments—with flexible rubrics, AI-assisted grouping of similar answers, and per-question analytics.

AI & Machine LearningEdTechSaaSBerkeley, US

ASArjun Singh(Founder)inIbrahim Awwal(Founder)Pieter Abbeel(Founder)

BoardDave Samuel(Director)MKManu Kumar(Director)inSKSergey Karayev(Founder)

Co-investorsBLBloomberg BetaGSGSV VenturesK9K9 VenturesFRFreestyle CapitalHOHouseIRIronfire Ventures+1 more

Gradient Medical develops INSPIRE therapy, an interventional oncology treatment that uses engineered electrical pulses to target cancer cells with real-time sensing for clinical control and adaptive energy delivery.

BiotechDeep TechHealthtechMedical Devices

Grain Weevil makes a robot that moves and manages grain inside storage bins, letting farmers maintain grain conditions and quality without physically entering the bin.

AgTechHardwareRoboticsAurora, US

CJChad Johnson(Co-Founder & CEO)inBJBen Johnson(Co-Founder / Chief Innovation Officer)in

Co-investorsAGAg Ventures AllianceHOHomegrown CapitalINInnova Memphis, Inc.INInvest Nebraska

GrammaTech provides services, research, and software products designed to identify critical security vulnerabilities in code.

CybersecurityDefense TechDeveloper ToolsIoT

Graphistry provides GPU-accelerated graph visualization and AI-powered analysis tools for security analysts and data teams to investigate events, detect attacks, and trace complex relationships in large datasets.

AI & Machine LearningCybersecurityData & Infrastructure

LMLeo Meyerovich(Founder)in

Co-investorsBLBloomberg BetaINIn-Q-TelSISINEWAVE VENTURES1111.2 Capital

FlashPCB provides PCB design and manufacturing services for hardware companies and engineers.

Advanced ManufacturingDeveloper ToolsHardwarePhiladelphia, US

Thomas Castner(CEO & Co-founder)George Woskob(CTO & Co-founder)

GrayMatter Robotics builds AI-powered robotic systems, marketed as Factory SuperIntelligence, that perform physically demanding industrial manufacturing tasks with high precision and reduced material waste.

Advanced ManufacturingAI & Machine LearningRoboticsGardena, US

AKAriyan Kabir(Founder)in

BoardARAlex Rubalcava(Director)inBrual Shah(Director)

Co-investorsADAdvance Venture PartnersB B Capital GroupB4B4 CapitalBOBow CapitalCACalibrate VenturesNGNGP Capital+5 more

Green Mountain Radio Research (GMRR) provides research, development, design, consulting, and seminars in RF power amplifiers, radio transmitters, radio communication, and radio navigation, and licenses proprietary technologies for manufacture.

Deep TechDefense TechHardware

Frederick H. Raab(Founder & Owner)

Green Mountain Semiconductor designs and develops semiconductor products and technologies for clients seeking advanced innovation in their own product development.

AI & Machine LearningDeep TechHardwareSemiconductors

GRC develops single-phase immersion cooling systems for data centers managing high-density computing, AI workloads, and next-generation networking infrastructure.

CleantechData & InfrastructureEnergyEnterprise SoftwareHardwareAustin, US

Peter(CEO)John(Chief Technology Officer)

Green Sun Medical makes the Whisper Brace, a dynamic scoliosis brace for adolescents that applies continuous corrective pressure while allowing movement, and pairs with an app that automatically tracks wear time for parents and care teams.

Digital HealthHealthtechMedical Devices

Co-investorsBVBVP Investors

GreenSight develops and manufactures catalog and fully custom robotic vehicles, selling standard designs directly as well as designing bespoke units for customers' specific applications.

AgTechDefense TechEdTechHardwareRoboticsBoston, US

James Peverill(Executive Officer, Director)inJustin McClellin(Executive Officer, Director)Joel Pedlikin(Executive Officer, Director)inWayne Crandall(Director)

Co-investorsEMEmerald Development Managers

Grid Logic develops binder-free, multi-material 3D printing of metal and ceramic powders, using support powder to hold part geometry and hot isostatic press (HIP) processing to fabricate fully-dense parts.

Advanced ManufacturingHardwareNew Materials

GridBridge develops power delivery solutions for electric utilities at substations and downstream distribution points.

CleantechCloud ComputingEnergyHardwareIoTRaleigh, US

Chad Eckhardt(Executive Officer, Director)

BoardDouglas P. Haensel(Director)

San Francisco, US

Kavita Bala(Executive Officer, Director)SBSean Bell(Executive Officer, Director)in

Co-investorsCACanaan PartnersAMAmino CapitalNENeuron.VCRERed Bear Angels

Guardion develops nanomaterial-based ion detectors that enable portable and sensitive analytical instruments for mass spectrometry, environmental monitoring, and chemical threat detection.

AI & Machine LearningDeep TechHardwareIoTBoston, US

DEDaniel Esposito(CEO)

BoardDSDr. Swastik Kar(2D Materials Expert)

Co-investorsTETechstars

GAINS is a mobile application that delivers real-time behavioral guidance and coaching for Applied Behavior Analysis (ABA) practitioners, instructors, and caregivers across clinical and educational settings.

AI & Machine LearningDigital HealthEdTechHealthtechSaaSPhiladelphia, US

John Nosek(Founder, President and CEO, Director of Research and Product Innovation)

Guild Associates develops and manufactures engineered systems and specialized materials for applications including chemical defense, decontamination, and demilitarization.

Deep TechDefense TechEnterprise SoftwareNew MaterialsDublin, US

Gust provides a platform for startup founders to incorporate their companies, manage cap tables and equity, and handle governance, risk, and compliance.

Enterprise SoftwareFintechFuture of WorkLegalTechSaaSNew York, US

DSDavid S. Rose(Executive Officer, Director)in

BoardHMHoward Morgan(Director)in

Co-investors3737 AngelsANAngels4WomenBEBeacon AngelsBRBroad Street AngelsFAFashion Capital PartnersIUIU Ventures+11 more

GVD develops customized nano- and micro-coatings using a polymer vapor deposition technology spun out of MIT in 2001.

Advanced ManufacturingCleantechDeep TechDefense TechNew MaterialsMIT (implied), US

H-Quest develops a process to produce zero-CO₂ hydrogen and carbon materials from domestic natural gas, aimed at securing supply chains for strategic carbon materials.

CleantechClimate TechNew Materials

Co-investorsICIcebook Investments Corp.

HabitAware makes Keen2, a vibrating awareness bracelet paired with recovery coaching and an online community to help people manage body-focused repetitive behaviors such as hair pulling, skin picking, and nail biting.

Digital HealthMental HealthWellness & FitnessSaint Louis Park, US

AIAneela Idnani(Executive Officer, Promoter)KKKirk Klobe(Co-founder & CTO)SKSameer Kumar(Co-founder & CEO)JPJohn Pritchard(Co-founder & Lead Hardware Engineer)AIAneela Idnani Kumar(Co-founder & Designer)

Co-investorsBABackstage CapitalSOSOSV

AvantGuard develops Avantamine, an antimicrobial molecule that eliminates bacteria, viruses, and fungi on surfaces and skin without generating resistance, with an initial focus on topical treatment of the drug-resistant fungal pathogen Candida auris.

BiotechHealthtechNew Materials

Co-investorsRERed Bear AngelsBLBlue Ledge CapitalSOSOSV

Harmonic Bionics develops Harmony SHR, a robotic system for upper extremity rehabilitation used to treat patients recovering movement, and partners with distributors outside the US.

Digital HealthMedical DevicesRoboticsAustin, US

ADAshish Deshpande(Executive Officer, Director)inYYYoungmok Yun(Executive Officer, Director)inChristopher Prentice(Executive Officer, Director)Adam Berman(Director)

BoardPYPhil Yoon(Director)in

Co-investorsBIBig Basin CapitalSWSWAN Impact Network

Harpe Bioherbicide Solutions develops natural, bio-based weed control products for agriculture and, through a partnership with SBM Life Science, the home and garden consumer market.

AgTechBiotechNew Materials

Co-investorsISiSelect Fund

Harvest Thermal makes an all-in-one home heating, cooling, and hot water system that pairs an air-to-water heat pump with an insulated thermal storage tank and optimization software to shift electricity use to cheaper, cleaner periods.

Advanced ManufacturingCleantechClimate TechEnergyHardwareKensington, US

JanePierreKMKen Munson(Executive Officer, Director)inElisabeth Jane Melia(Executive Officer, Director)

Co-investors3737 AngelsASAstiaBEBerkeley Angel NetworkCLClimate Impact CapitalCOCool Climate CollectiveDADangerous Ventures+10 more

SP3 is a seismic performance prediction platform providing building-specific seismic risk analysis based on the FEMA P-58 methodology for resilient structural design.

Construction TechDeep TechSaaS

Hats & Ladders provides a digital career exploration curriculum and platform for K-12 students to discover career pathways, develop workplace skills, and plan their educational and professional futures.

Creator EconomyEdTechFuture of WorkSaaS

Leah Potter(President & Co-Founder)David Langendoen(CFO & Co-Founder)Scott Brewster(Director of Partnerships & Co-Founder)

Hawaiʻi Integrated Analytics is a research and strategy firm that combines cultural knowledge with data analytics to advance health equity and support Native Hawaiian communities.

Data & InfrastructureDigital HealthHealthtechImpact & Social GoodHawaiʻi, US

Healing Innovations develops robotic rehabilitation technology aimed at improving health, mobility, and independence for people recovering from neurological injuries.

HealthtechMedical DevicesRoboticsNashville, US

SBScott Benda(Executive Officer, Director)inLBLuke Benda(Executive Officer, Director)in

Co-investorsLALaunch TennesseeTETechFarms Capital

Health Technology Innovations develops AI automation software for pharmaceutical research workflows, specifically targeting cryo-electron microscopy (Cryo-EM) data collection and sample screening.

AI & Machine LearningBiotechDeep TechCleveland, US

Tuan Phamdo(CEO and Founder)

HealthMyne develops QIDS, a quantitative imaging and clinical decision support platform for oncology care teams that tracks incidental findings, supports tumor conference preparation, and provides quantitative imaging metrics such as lesion volume and texture analysis.

AI & Machine LearningDigital HealthHealthtechMedical DevicesMadison, US

RCRoger Chylla(Executive Officer, Director)inHao Wang(Executive Officer)inPSPraveen Sinha(Executive Officer, Director)inASArvind Subramanian(Executive Officer, Director)inThomas Rockwell Mackie(Director)

BoardGreg Robinson(Director)

Co-investorsALAlumni VenturesASAscension VenturesBABascom Ventures444490 Ventures

Blacksand Technology commercializes titanium production technologies developed from University of Utah research, spanning mineral processing through alloy manufacturing.

Advanced ManufacturingDeep TechNew MaterialsSalt Lake City, US

Z. Zak Fang(Professor)

HelioBioSys develops biological production systems using cyanobacteria to extract and purify high-value compounds such as mycosporine-like amino acids and polysaccharides for industrial and consumer applications.

Advanced ManufacturingBiotechCleantechDeep TechNew Materials

Rocco Mancinelli(Co-founder, Inventor, and CEO)David Smernoff(Co-founder, Inventor, and CTO)

HelixBind develops a diagnostic platform for bloodstream infections that delivers microbiology results in about 4 hours to help clinicians identify invasive infections and choose antimicrobial treatments.

BiotechHealthtechMedical DevicesMarlborough, US

Alon Singer(Executive Officer, Director, Promoter)inLarry Pearson(Director)Sheppard Mollick(Director)

Co-investorsARArieal Southeast Angel Partners

HEN develops hardware and software for fire suppression and firefighting, spanning system-, engine-, and firefighter-level solutions such as fluidics, controls, and decision support.

Deep TechHardwareIoT

Hera Health Solutions is a biotechnology company that develops a proprietary nanotechnology platform to reformulate existing pharmaceutical compounds into more effective and longer-acting therapies.

BiotechDeep TechHealthtechMedical DevicesMemphis, US

Garrett Whitfield(Executive Officer, Director)Idicula Mathew(Executive Officer, Director)

Co-investorsINInnova Memphis, Inc.LALaunch TennesseeTETechstarsINInnovaMIMicroVentures

HeroWear designs exoskeleton technology to protect workers from back injuries in physically demanding roles such as warehousing, manufacturing, and military settings.

HardwareHealthtechLogistics & Supply ChainRoboticsWellness & Fitness

Karl Zelik(Chief Scientific Officer & Co-founder)Matt Yandell(Chief Technology Officer & Co-founder)

HeXalayer develops and supplies advanced materials—including turbostratic graphene and other carbon materials—for research and product development in electrochemistry, conductive and thermal composites, sensing, catalysis, coatings, and energy storage.

Deep TechEnergyNew MaterialsLouisville, US

HVHarut Vardanyan(Founder)in

Co-investorsCACapital Innovators

Hi-Z manufactures thermoelectric generator modules and related accessories that convert heat differentials into electrical power for industrial and research applications.

Deep TechEnergyHardwareNew Materials

Develops advanced materials and electrochemical technologies, including geopolymers, electrochemical processes and sensors.

Deep TechDefense TechNew Materials

Higgins Environmental provides water quality remediation using its patented A-Pod technology to remove harmful algae, cyanobacteria, cyanotoxins, and excess nutrients from fresh and estuarine water bodies.

CleantechClimate TechImpact & Social Good

Hinge Bio is a biotechnology company developing next-generation therapeutics based on its GEM-DIMER platform, aimed at improving efficacy and reducing resistance and side effects.

BiotechHealthtechBurlingame, US

Daniel J. Capon(Director)CMCarin Mueller Rollins(Co-Founder & Chief Operating Officer)HEHarold E. Selick, PhD(Executive Officer, Director)Miriam Siekevitz(Executive Officer)inHarold E. "Barry" Selick(Chief Executive Officer & Director)PBPaul Brunetta(Chief Medical Officer)in

Co-investorsPOPoint72AGAgent CapitalBABaruch Future VenturesINInVivium CapitalRIRidgeback Capital

Histogen is a clinical-stage drug development company creating small-molecule pan-caspase and caspase-selective inhibitors intended to restore immune function and treat infectious and inflammatory diseases.

BiotechHealthtech

HistoneTx develops precision epigenetic reprogramming therapeutics that use engineered effectors and transient mRNA delivery via non-viral vectors to activate or restore expression of silenced genes without altering DNA.

BiotechDeep TechLongevity

Hospi Corporation develops FDA-cleared medical devices for hospice and palliative care patients, focusing on improving comfort and easing caregiver burden.

HealthtechMedical DevicesSan Mateo, US

Brad Macy(Co-founder)

Howe Industries develops space and terrestrial technologies derived from expertise in nuclear technologies, thermal systems, and space propulsion.

Deep TechEnergyHardwareSpace Tech

Troy Howe(CEO)

HumanGO is an AI-powered training platform that creates personalized, adaptive workout plans for cyclists and endurance athletes.

AI & Machine LearningConsumerFuture of WorkSports TechWellness & Fitness

Lexington, US

LYNDON SCOTT STEPHENS(Executive Officer, Director)RAYMOND GRANT STEPHENS(Director)BILLY HARPER(Director)

Co-investorsBLBluegrass Angel Venture

Hummingbird Scientific develops advanced in-situ microscopy instrumentation for electron, X-ray, and ion microscopy, enabling real-time nanoscale observation for scientific research.

AI & Machine LearningDeep TechHardwareNew Materials

Huxley develops SANSA, a cellular-enabled chest-worn monitor and diagnostic service that detects obstructive and central sleep apnea and records ECG from a single at-home device.

AI & Machine LearningDigital HealthHealthtechMedical DevicesAtlanta, US

CHChristopher Hallett(Executive Officer, Director)inChristopher Lee(Executive Officer, Director)DBDaniel Burnham(Executive Officer)inBrennan Torstrick(Executive Officer, Director)inKenneth Gall(Director)

BoardKurt Jacobus(Director)

Co-investorsDUDuke Capital PartnersGRGRA Venture

Hydronalix designs and manufactures unmanned surface vessels and robotic water rescue systems for the US military and commercial markets.

Defense TechHardwareRobotics

Anthony Mulligan(CEO)

Hypersound Medical develops a proprietary radio frequency neuromodulation device for non-invasive pain management, targeting clinical and home use applications.

BiotechDeep TechHardwareHealthtechMedical Devices

Hyphae Design Laboratory is an ecological design and engineering firm whose team of ecologists, engineers, and landscape architects treats landscape as a therapeutic intervention, as in Louisville's Green Heart Project clinical trial.

CleantechClimate TechImpact & Social GoodOakland, US

Brent Bucknum(Founding Principal)

HYPRES designs and manufactures superconductor integrated circuits and related cryogenic equipment for high-speed digital and mixed-signal applications.

Deep TechDefense TechHardwareSemiconductors

IAMBIC manufactures precision-fit shoes using AI-powered 3D foot scanning and computer vision technology paired with traditional shoemaking.

AI & Machine LearningConsumerHardwareNew York City, US

MWMaeve Wang(Co-founder & CEO)inDRDr. Raza Hassan(Co-founder & CTO)

Co-investorsTETechstars

IASO Therapeutics develops synthetic antigen vaccines using a mutant Qβ virus-like particle carrier platform to generate targeted, durable immunity.

BiotechHealthtechEast Lansing, US

Robert Forgey(President & CEO)Xuefei Huang(Executive Officer, Director)Herbert Kavunja(Executive Officer)

BoardDonald Parfet(Director)JWJeffrey Wesley(Director)inSteve Kuemmerie(Director)

Co-investorsMIMichigan RiseWMWMU Biosciences Research & Commercialization Center

Revelen.AI (iBallistix) builds AI and machine-learning tools that match ballistics evidence using mobile forensics devices to help identify weapons and suspects.

AI & Machine LearningDeep TechGovTech

IBC develops and manufactures Molecular Recognition Technology (MRT) products, processes, and engineered systems for highly selective separation of metals, cations, anions, and bio molecules based on green chemistry principles.

Advanced ManufacturingCircular EconomyCleantechDeep TechNew Materials

Dr. Reed M. Izatt(Founder)Dr. Jerald S. Bradshaw(Founder)Dr. James J. Christensen(Founder)Steven R. Izatt(President and CEO)

iBeam Materials develops ion-beam crystal alignment technology for manufacturing high-performance gallium nitride (GaN) devices on large-area substrates, enabling low-cost microLED displays and semiconductor applications.

Deep TechHardwareNew MaterialsSemiconductorsSanta Fe, US

Vladimir Matias(Founder & CEO)

Co-investorsSASamsung Ventures

IBS Caribe is a Process Analytical Technology (PAT) provider supplying software, analyzers, and instrumentation systems to pharmaceutical, bio-pharmaceutical, and medical device manufacturers in Puerto Rico.

Advanced ManufacturingBiotechDeep TechEnterprise SoftwareHealthtechMedical DevicesPuerto Rico, PR

Manuel Hormaza(President)

Icorium Engineering develops advanced separation technologies to recover and recycle complex refrigerant mixtures from industrial and commercial systems.

Advanced ManufacturingCircular EconomyCleantechClimate TechLawrence, US

Kalin Baca(Co-Founder & Chief Executive Officer)Mark Shiflett(Co-Founder & Chief Science Officer)Abby Harders(CTO)

Ictero develops the CholeSafe System, a minimally invasive gallbladder ablation device for treating gallstone disease.

BiotechHealthtechMedical DevicesHouston, US

MNMatthew Nojoomi(CEO, Co-Founder)DWDavid Waters(COO, Co-Founder)inKBKovi Bessoff(Clinical Research Lead, Co-Founder)RKRaymond Kirk(CMO)

BoardAshok Gowda(Director)John Fichthorn(Director)

Co-investorsTETexas HALO FundTMTMC Venture FundMEMedTex Ventures LLCS3S3 Ventures

IERION develops AI-enabled cybersecurity technologies and products focused on responsible AI, addressing AI governance, bias mitigation, and explainability.

AI & Machine LearningCybersecurityEnterprise Software

iFyber is a product development and research services firm that helps companies commercialize technologies at the intersection of chemistry, biology, and materials science.

BiotechDeep TechHealthtechMedical DevicesNew MaterialsIthaca, US

Aaron Strickland(Co-founder & Vice President of Research and Development)

PrintFoam develops patented hardware and materials technology to 3D print foam objects with real bubbles and tunable material properties for applications traditionally made from foam, such as helmets, bike seats, and shoe soles.

Advanced ManufacturingHardwareNew Materials

Matthew Pearlson(CEO & Co-Founder)Dr. David Walker(CTO & Co-Founder)

Illuminant Surgical develops an AI-powered real-time anatomical projection system called Skylight for spine surgery and interventional procedures, using computer vision and projection mapping to display medical imaging directly onto patients.

AI & Machine LearningDeep TechHealthtechMedical DevicesLos Angeles, US

EMEldrick Millares(Founder)inJHJames Hu(Co-Founder, Co-Chief Executive Officer)inJhoneldrick Millares(Cofounder)Brian Nguyen(Mechanical Engineering)Joseph Gu(Software Engineer)Enoch Omale(Software Engineering)

Co-investorsDODorm RoomFLFlucas VenturesKUKube VCSOSoma CapitalY Y CombinatorALAlumni Ventures+4 more

VizSeek is a visual AI search platform that helps industrial and manufacturing companies find parts, compare designs, and extract data from technical documents and 3D models.

Advanced ManufacturingAI & Machine LearningData & InfrastructureEnterprise SoftwareWest Lafayette, US

Vipo develops, manufactures, and installs high-performance polymer solutions for corrosion, fire protection, and thermal insulation used in demanding environments.

Advanced ManufacturingEnergyNew Materials

Imbed Biosciences is a medical device company that develops SAMatrix, an ultra-thin, fully synthetic bioresorbable wound matrix that integrates antimicrobial silver and non-opioid pain agents (lidocaine) for treating chronic and acute wounds such as ulcers, surgical, traumatic, and burn wounds.

BiotechHealthtechMedical DevicesMadison, US

NLNicholas L Abbott(Executive Officer, Director)inAAAnkit Agarwal(Executive Officer, Director)in

BoardDavid Guinther(Director)Robert A Beckman(Director)

Co-investorsWIWisconsin Investment Partners

Immersed Games is a research-driven studio that develops game-based learning tools and platforms backed by scientific evidence.

EdTechGamingGainesville, US

Lindsey Tropf(Executive Officer, Director)

Immunant is a systems software consultancy that performs applied research and development to improve the security and reliability of low-level software, including hardening user, kernel, and hypervisor code, migrating critical C/C++ to Rust, exposing C/C++ to Rust via APIs, and applying fuzzing and exploit mitigations.

CybersecurityDeep TechDeveloper Tools

Impactivo provides data analysis and consulting services to healthcare organizations, enabling leaders to make decisions that balance measurable business outcomes with improvements in patient and community wellbeing.

Data & InfrastructureDigital HealthEnterprise SoftwareHealthtechWellness & FitnessSan Juan, PR

Impressio develops and commercializes Liquid Crystal Elastomers (LCEs) for use in sports equipment, military gear, medical devices, and wearables to improve impact protection, vibration damping, and thermal management.

Deep TechHardwareMedical DevicesNew Materials

Josh Ray(Chairman & CEO)

Co-investorsNCNC IDEA

Inanovate is a diagnostics company that developed Lyme-ID, an FDA 510(k)-cleared blood test for Lyme disease based on its proprietary Bio-ID technology.

BiotechSioux Falls, US

David Ure(Executive Officer, Director)inJames E Oury(Executive Officer)

BoardBlaine Crissman(Director)Katie Pohlson(Director)Peter D. Los(Director)David Arslanian(Director)

Incom manufactures glass and polymer microstructures used in optical and display applications for medical, dental, scientific, and defense industries.

Deep TechDefense TechHardwareMedical DevicesNew MaterialsCharlton, US

Indrio Technologies develops portable, high-accuracy chemical sensors based on modern laser spectroscopy to measure chemical concentrations for industrial and mass-market applications.

CleantechDeep TechHardwareIoTMobility & TransportationSan Jose, US

Peter Chidyllo(Director)Ritobrata Sur(Executive Officer, Director)Rito Sur(Founder / CEO)

Co-investorsSTStartX

IAMECON (Intelligent Analytics and Modeling, Inc.) is a damages expert witness and economic consulting firm that provides litigation support, expert testimony, and computational modeling for law firms, government agencies, and businesses.

AI & Machine LearningData & InfrastructureLegalTechAustin, US

Devrim Ikizler(Founder & Lead Damages Expert)

iMicrobes uses synthetic biology to develop cost-effective sustainable materials and replace conventional manufacturing processes.

BiotechCircular EconomyCleantechClimate TechHealthtechNew MaterialsSan Francisco, US

DGDerek Greenfield(CEO)inLCLiz Clarke(CTO)inNHNoah Helman(CSO)inAnne-Marie Rosche(Office Manager)

Co-investorsCLCLI VenturesFIFirst Bight VenturesJUJude GomilaJUJuniperPOPoint Reyes ManagementSTStartX+9 more

InferLink applies artificial intelligence and statistical inference to solve complex problems for clients across multiple sectors.

AI & Machine LearningData & InfrastructureDeep TechEnterprise Software

Steven Minton(President and Founder)

Infinite Composites designs, manufactures and analyzes composite pressure vessels for aerospace, aviation, defense, bulk gas transport and vehicular transportation applications.

CleantechDefense TechEnergyNew MaterialsSpace TechTulsa, US

Co-investorsCECentral Texas Angel NetworkIRIrishAngelsTETechstars

Infinity Physics develops physical technology aimed at turning physicists' concepts into real-world inventions.

Deep Tech

infinut is the maker of infinut Math, a set of touch-based educational games that teach Kindergarten through 2nd grade math concepts using virtual manipulatives, aligned to Common Core standards.

AI & Machine LearningEdTechSeattle, US

Ana Redmond(Founder)

Influit Energy develops Nano-Electro Fuel (NEF) battery technology designed as a more efficient, cost-effective alternative to lithium-ion batteries for utility-scale energy storage and electric vehicles.

CleantechEnergyHardwareNew MaterialsChicago, US

InformAI develops AI-guided clinical solutions for oncology and diagnostic imaging to improve patient treatment outcomes.

AI & Machine LearningDigital HealthHealthtechMedical DevicesHouston, US

Co-investorsJOJoyance PartnersSOSocial StartsDEDEFTA PartnersJPJP Morgan Chase

ISL is a government contractor providing technical, engineering, and professional services to the U.S.

AI & Machine LearningClimate TechDeep TechDefense TechDeveloper ToolsEnergyEnterprise Software

InfuSense develops an electrochemical sensing technology platform that detects analytes at sub-therapeutic levels, delivering sample analysis results within minutes.

BiotechDeep TechHardwareMedical DevicesNashville, US

EKEric Kriegstein(CEO)inECEdward Chaum(Executive Officer, Director)

BoardASANDY SASLAWSKY(Director)BLBRUCE LANDAU(Director)

Co-investorsEVEvolution VC Partners

InitWeather provides meteorological forecasting, numerical weather prediction, data assimilation, and custom weather modeling for sectors including agriculture, aerospace launches, commodities and financial markets, maritime routing, and defense clients such as the U.S.

Data & InfrastructureDeep TechDefense Tech

Inkbit operates an additive manufacturing platform built on Vision-Controlled Jetting, which combines real-time 3D machine vision with closed-loop feedback and a custom material portfolio to produce dimensionally accurate, multi-material parts.

Advanced ManufacturingDeep TechHardwareNew MaterialsMedford, US

DMDavide Marini(Founder)inJRJavier Ramos(Co-founder & Chief Technology Officer)WMWojciech Matusik(Co-Founder & Scientific Advisor)SKSteffi Kochbeck(VP Market Development)Guy Menchik(Director)Jason Weber(Director)

Co-investorsALAlumni VenturesGCGC VenturesIGiGlobe PartnersMAMassVenturesPHPhoenix Venture PartnersZEZeon Ventures

InkSpace Imaging develops MRI coil technology and patient-centered diagnostic imaging solutions, drawing on expertise in MRI coil design, medical device manufacturing, and regulatory compliance.

HardwareHealthtechMedical DevicesPleasanton, US

Peter Fischer(Executive Officer, Director)George Rehm(Director)Jacques Coumans(Director)Shimon Michael Lustig(Director)Scott Gorton(Executive Officer)

InnAVasc develops a vascular access graft for hemodialysis, featuring self-sealing pods and puncture-resistant backplates that guide dialysis needle placement to reduce needle-injury and bleeding complications.

BiotechHardwareHealthtechMedical DevicesDurham, US

Shawn Gage(Executive Officer)Jeffrey Lawson(Executive Officer, Director)Joseph Knight(Executive Officer, Director)Roberto Duane Manson(Executive Officer)

BoardDani Bolognesi(Director)

Co-investorsARArieal Southeast Angel PartnersDUDuke Capital PartnersHAHatteras Venture Partners

Innerspec develops non-destructive testing (NDT) equipment and inspection services, including ultrasonic, phased array, eddy current, and laser measurement technologies for industrial asset inspection.

Advanced ManufacturingAI & Machine LearningDeep TechHardwareIoTForest, US

Innoblative Designs develops a medical device for breast-conserving therapy, focused on treating breast cancer during surgical procedures.

Medical DevicesChicago, US

Tyler Wanke(Executive Officer, Director)in

Co-investorsALAlumni VenturesBABascom VenturesBOBoston Harbor Angels

Innogized Technologies develops hardware and software solutions aimed at consumer applications, taking a cross-disciplinary approach across science and engineering to build new technologies.

ConsumerDeep TechHardware

Oliver SmithSarah Smith

An R&D firm that commercializes engineered technologies and research into market-ready solutions addressing real-world problems.

Deep TechDefense TechMedical DevicesNew MaterialsTorrance, US

Dr. Kisholoy Goswami(Cofounder)Uma Sampathkumaran(Senior Vice President of R&D)

AutoDuck provides robotic charging systems and fleet orchestration software for autonomous and commercial vehicle operators.

Advanced ManufacturingAI & Machine LearningDeep TechEnterprise SoftwareIoTMobility & TransportationRobotics

Innovas Technologies manufactures automatic tube cleaning systems for heat exchangers used in HVAC, power generation, and oil and gas applications.

Advanced ManufacturingCleantechHardwareIoTCedar Rapids, US

Innovative Dynamics Inc. develops ice detection and deicing systems, sold under its IceSight and EPIPS product lines, for adverse weather hazards across highways, runways, parking lots, aircraft, and marine vessels.

Deep TechDefense TechHardware

Innovative Scientific Solutions Incorporated (ISSI) is an engineering R&D company providing measurement and instrumentation solutions for fluid dynamics, aerodynamics, combustion analysis, and optical diagnostics.

Deep TechDefense TechEnterprise SoftwareHardwareDayton, US

Inovati develops kinetic metallization coating systems that deposit fully dense, metallurgically bonded surface coatings for wear and corrosion protection across aerospace, defense, and industrial components.

Advanced ManufacturingDeep TechDefense TechHardwareNew Materials

Innsightech develops technology for disease diagnosis and management that translates laboratory innovations into clinical applications.

Digital HealthHealthtechMedical DevicesPittsburgh, US

Leanne Labriola(Executive Officer, Director, Promoter)Dipanjan Pan(Executive Officer)

BoardGJGregory Jackson(Director)

Co-investorsLILife Sciences Greenhouse InvestmentsSOSOSVRIRichard King Mellon Foundation

Innsightful provides a mental health platform with AI and machine learning capabilities designed for young adults to manage stress and anxiety through biometric monitoring and real-time interventions.

AI & Machine LearningHealthtechMental HealthWellness & Fitness

Farzad Ehsani(Co-Founder and CEO)Demitrios Master(Co-Founder and CTO)David L. Pennington(Chief Clinical Officer)

ROIHire is a hiring platform that aggregates candidate information, workforce program data, and predictive analytics to help employers identify available federal and state hiring incentives, estimate retention probability, and project the financial ROI of each candidate.

AI & Machine LearningHR TechSaaS