Pontifax Venture Capital — Full Portfolio

Adicet Bio develops allogeneic gamma delta CAR T cell therapies for patients with autoimmune diseases and cancer.

BiotechHealthtechMenlo Park, US

Aya Jakobovits(Executive Officer, Director)NHNathan Hubbard(Executive Officer)inChen Schor(President, Chief Executive Officer and Director)in

BoardJSJonathan Silverstein(Director)inCGCarl Gordon(Director)inFlorent Gros(Director)

Co-investorsFOForesite CapitalOROrbiMedQUQuan CapitalAMaMoonNONovartis Venture FundPUPureTech Health

Check-Cap is a clinical-stage medical diagnostics company that developed the C-Scan System, an ingestible capsule for colorectal cancer screening that requires no bowel preparation or sedation.

AI & Machine LearningBiotechDeep TechEnterprise SoftwareHealthtechMedical DevicesRoboticsIsfiya, IL

Lior Torem(Executive Officer)Yoav Kimchy(Executive Officer)Yuval Yanai(Director)Alex Ovadia(Executive Officer)Walter Robb(Director)William Densel.(Executive Officer, Director)

Co-investorsPRProsper Startup Accelerator

Enlivex is a Nasdaq-listed clinical-stage biotech developing Allocetra, a macrophage reprogramming immunotherapy targeting age-related knee osteoarthritis to restore mobility and function in aging populations.

BiotechCrypto & Web3Longevity

Biotechnology company developing orally available therapies for chronic inflammatory and autoimmune diseases.

BiotechNew York, US

AMAndreas Muehler(Executive Officer)inDVDaniel Vitt(Executive Officer, Director)inINDERPAL SINGH(Executive Officer)inHella Kohlhof(Executive Officer)inPatrick Walsh(Executive Officer)Aron Stern(Executive Officer)

Co-investorsBABayern KapitalBMbmp VenturesFUFund+OMOmega Funds

Keros is a clinical-stage biopharmaceutical company developing product candidates that modulate signaling of the transforming growth factor-beta (TGF-β) family of proteins to treat disorders affecting blood cells and tissues such as bone, muscle, adipose and heart.

BiotechHealthtechLexington, US

Jasbir S. Seehra(Executive Officer, Director)inJasbir Seehra(Co-Founder, Chief Executive Officer and Director)in

BoardJulius Knowles(Director)ALAlon Lazarus(Director)inOhad Hammer(Director)Ran Nussbaum(Director)in

Co-investorsARArkin CapitalFOForesite CapitalOROrbiMed

Mereo BioPharma is a biopharmaceutical company publicly traded on Nasdaq under the ticker MREO.

BiotechHealthtechLondon, GB

JRJohn Richard(Head of Corporate Development and Co-Founder)inCharles Sermon(General Counsel and Co-Founder)Richard Jones(Chief Financial Officer)inJill Henrich(Senior Vice President)inDenise Scots-Knight(Chief Executive Officer)in

BoardDr. Deepa Pakianathan(Non-Executive Director)

Co-investorsVIVivo CapitalWOWoodford Investment Management

Protalix is a biopharmaceutical company that develops and manufactures innovative pharmaceutical products, including treatments for orphan and rare diseases.

BiotechHealthtechMedical DevicesKarmiel, IL

Moshe Bashan(President and Chief Executive Officer)DBDror Bashan(President and Chief Executive Officer, Director)in

Co-investorsSOSofinnova Ventures

Soligenix is a biopharmaceutical company developing treatments for rare diseases, with programs in photodynamic therapy for cutaneous T-cell lymphoma and psoriasis, immunomodulatory drugs for inflammatory conditions, and vaccine candidates for infectious diseases.

BiotechPrinceton, US

RCRichard C. Straube, MD MSc(Executive Officer)Karen Krumeich(Executive Officer)Oreola Donini, PhD(Executive Officer)CJChristopher J. Schaber, PhD(Executive Officer, Director)inChristopher J. Schaber(Chairman of the Board, Chief Executive Officer and President)inAdam T. Rumage(Executive Officer)

Abcuro develops therapies that target highly cytotoxic T cells for autoimmune diseases, including its lead candidate ulviprubart for inclusion body myositis.

BiotechHealthtechNewton, US

Steven A. Greenberg(Chief Scientific Advisor & Co-Founder)Steven A. Greenberg, MD(Chief Scientific Advisor & Co-Founder)John Alexander Martin(Executive Officer, Director)Stefano Gulla(Executive Officer)Evan Thompson(Executive Officer)David de Graaf(Executive Officer, Director)

Board seatTomer Kariv· per SEC Form D

Co-investorsBABain Capital Life SciencesNENew Enterprise Associates (NEA)RARA CapitalSASamsara BioCapitalSASanofi VenturesMAMass General Brigham Ventures+8 more

UroGen is a biotech company developing treatments for urothelial and specialty cancers using a proprietary sustained-release hydrogel platform technology.

BiotechHealthtechMedical DevicesPrinceton, US

Mark Schoenberg, M.D.(Executive Officer)LBLiz Barrett(President and Chief Executive Officer)inJason Smith(Executive Officer)Arie Belldegrun, M.D.(Director)Dan Wildman(Director)Don Kim(Executive Officer)

Board seatRan Nussbaum· per SEC Form D

Co-investorsAIAisling CapitalMOMonograph Capital Partners

Adcendo develops antibody-drug conjugates (ADCs) targeting cancers with high unmet medical need.

BiotechMedical Devices

Co-investorsVIVida VenturesHEHealthCapJEJeito CapitalNONovo HoldingsOROrbiMedRARA Capital+2 more

Adcytherix is a clinical-stage biopharmaceutical company developing next-generation antibody-drug conjugates (ADCs) that use approved cancer drugs as payloads combined with optimized conjugation design to overcome resistance in precision oncology.

BiotechHealthtechMedical Devices

JEJack Elands(Founder & CEO)inXPXavier Preville(Co-founder, VP & Head of Research & Preclinical Development)inJHJan H.M. Schellens(Chief Medical Officer)inTMThierry Menguy(VP & Head of CMC Operations)inJAJaime Arango(Chief Financial Officer)inPJPaul Jackson(Chief Operating Officer)in

Co-investorsAMaMoonRARA CapitalBPBpifranceANAndera PartnersANAngelini VenturesKUKurma Partners+1 more

Agomab is a clinical-stage biopharmaceutical company developing disease-modifying therapies for fibro-inflammatory and fibrotic diseases with high unmet medical need.

BiotechHealthtechMedical DevicesAntwerp, BE

TKTim Knotnerus(Chief Executive Officer)in

Co-investorsEQEQT Life SciencesADAdBio partnersANAndera PartnersASAsabys PartnersCACanaan PartnersV-V-Bio Ventures+1 more

Anaveon develops engineered antibodies targeting immune system regulatory nodes to treat autoimmune diseases by selectively eliminating or reprogramming pathogenic immune cells.

BiotechBasel, CH

TThaminda(Chief Business Officer)inLPLaetitia Pouzol(Chief Scientific Officer)in

Co-investorsNONovartis Venture FundPFPfizer Venture Investments

Antios Therapeutics develops antiviral therapies for hepatitis B virus (HBV) and other viral diseases, including its Active Site Polymerase Inhibitor Nucleotide (ASPIN) ATI-2173 and a capsid assembly modulator program.

BiotechHealthtechMendham, US

Gregory Mayes(Executive Officer, Director)DMDouglas Mayers(Executive Officer)inTATamra Adams(Executive Officer)inAbel De La Rosa(Director)

BoardIyona Rajkomar(Director)inBenjamin Rovinski(Director)

Co-investorsAIAisling CapitalALAltium CapitalAVAvego BioScience CapitalAMAmzak HealthDEDelos CapitalDODomain Associates+8 more

CathWorks develops the FFRangio System, a medical device that uses artificial intelligence and imaging technology to improve the diagnosis and treatment of coronary artery disease for interventional cardiologists and cardiac patients.

AI & Machine LearningDigital HealthMedical Devices

Ran Kornowski, MD, FESC(Co-Founder)Guy Lavi(Co-Founder)Ifat Lavi, PhD(Co-Founder)

Co-investorsPLPlanven Entrepreneur VenturesTRTriventures

This site publishes articles about regulatory affairs for immunotherapy, covering topics such as EMA approval processes, orphan drug designation, biomarkers, clinical trials, and compliance in manufacturing.

Biotech

CytoReason builds a computational disease model that maps disease and drug mechanisms by modeling and comparing treatments and patient groups.

AI & Machine LearningBiotechHealthtech

Co-investorsASAsymmetry Ventures

Eloxx Pharmaceuticals is a clinical-stage biopharmaceutical company developing small molecule therapeutics designed to address nonsense mutation genetic disorders.

BiotechHealthtechLongevityMedical Devices

SASumit Aggarwal(President and Chief Executive Officer)in

EyeYon Medical develops medical devices for corneal diseases, including EndoArt®, a synthetic implant for chronic corneal edema, and HyperCL™, a therapeutic contact lens for enhancing drug absorption in corneal conditions.

HardwareHealthtechMedical DevicesTel-Aviv, IL

NFNahum Ferera(CEO, Co-founder)inDr. Ofer Daphna(Chief Medical Officer, Co-founder)Prof. Arie Marcovich(Co-founder)

Co-investorsTRTriventures

HealthtechParis

Ronald Buggage(Executive Officer)Thierry Bordet(Executive Officer)Francine Behar Cohen(Executive Officer, Promoter)Patricia Zilliox(Executive Officer, Director, Promoter)

Co-investorsKAKarista

Fore Biotherapeutics is a clinical-stage oncology company developing targeted cancer therapies, including its lead plixorafenib program.

BiotechHealthtechMedical DevicesPhiladelphia, US

Co-investorsLGLG Technology VenturesNONovartis Venture FundOROrbiMedSRSR One Capital ManagementWIWindham Capital PartnersMEMedicxi+1 more

Graviton offers an AI model trained on blockchain technology, including Solidity, to help developers build Web3 decentralized applications (dApps) from a prompt.

AI & Machine LearningCrypto & Web3Developer Tools

Co-investorsBLBlueYard Capital

Graviton develops immunomodulatory therapies for patients with fibrotic, autoimmune, and central nervous system diseases.

AI & Machine LearningBiotechDeep TechHealthtech

Samuel Waksal(Founder & CEO)

Imel Biotherapeutics is a biotech company focused on mitochondrial biology, targeting mitochondrial dysfunction implicated in aging, cellular senescence, and T cell exhaustion in the elderly population.

BiotechLongevity

Co-investorsRDRDiscovery

Kite develops CAR T-cell therapies that engineer a patient's own immune cells to target and destroy cancer cells.

BiotechHealthtechSanta Monica, US

ASArie S. Belldegrun(Executive Officer, Director)inMargo R. Roberts(Executive Officer)CBCynthia Butitta(Executive Officer)inMBMarc Better(Executive Officer)inRizwana Sproule(Executive Officer)in

BoardJoshua A. Kazam(Director)

Co-investorsALAlta Partners

LogicBio is a biotechnology company focused on research and development of treatments for rare diseases, investigating new targets, modalities, and technologies for patients and their families worldwide.

BiotechHealthtechCambridge, US

Leszek Lisowski(Executive Officer, Director)Mark A. Kay(Director)Adi Barzel(Executive Officer, Director)

BoardECErez Chimovits(Director)in

Co-investorsANAndera PartnersARArix BioscienceOROrbiMed

Lutris Pharma develops targeted skin protection treatments for cancer patients, combining clinicians and scientists with oncology expertise.

BiotechDigital HealthHealthtechMedical Devices

Antoni Ribas, M.D., Ph.D.(Founder and Chairman of the Board)SRSumant Ramachandra(Chief Executive Officer and Board Director)inJonathan Benjamin(Clinical Development Lead)

Co-investorsAMaMoonPEPeregrine Ventures

Nuvectis is a biopharmaceutical company developing oral small molecule therapies for cancer, including NXP900, an SRC Family Kinase inhibitor, and NXP800, a GCN2 activator being evaluated in solid tumors such as ovarian cancer and cholangiocarcinoma.

BiotechHealthtechFort Lee, US

James Oliviero(Director)Enrique Poradosu(Executive Officer)Matthew Kaplan(Director)Michael Carson(Executive Officer)Kenneth Hoberman(Director)Ron Bentsur(Executive Officer, Director)

OCON Medical develops intrauterine devices for gynecological conditions, including non-hormonal contraception and treatments for abnormal uterine bleeding.

BiotechFemTechHealthtechMedical Devices

Ilan Baram(MD, Inventor of the IUB®)KLKeren Leshem(Chief Executive Officer)in

Co-investorsASAstiaFOForeground Capital

Oxurion is a French specialist in clinical biometrics and data management, providing the core technology for the Oxurion platform.

AI & Machine LearningBiotechData & InfrastructureHealthtechMedical DevicesBrussels, BE

Co-investorsNENegma Group

ProQR develops medicines for patients with unmet medical needs, focusing on therapeutic development in biotech.

BiotechHealthtechMedical DevicesLeiden, NL

Co-investorsINInvivo Capital PartnersSOSofinnova Partners

Raziel develops a proprietary fat-dissolving injectable compound (RZL-012) for non-surgical, one-time focal fat reduction addressing both aesthetic and therapeutic needs, including submental (double-chin) fat and Dercum's disease.

BiotechHealthtechMedical DevicesHod Hasharon, IL

Alon Bloomenfeld(CEO & Founder)

Co-investorsPEPeregrine Ventures

Lifeward (ReWalk) develops wearable exoskeletons and related products for physical rehabilitation and recovery, used in conditions such as spinal cord injury, brain injury, stroke, multiple sclerosis, and orthopedic/sports medicine.

HealthtechMedical DevicesRobotics

Co-investorsSCSCP Vitalife Partners

RyCarma Therapeutics develops a novel drug class called Rycals to treat orphan skeletal muscle and cardiac diseases, building on foundational cardiovascular research and drug-delivery technologies.

BiotechHealthtechMedical DevicesNew York, US

ARAndrew R. Marks(Founding Scientist, MD)

Co-investorsKUKurma Partners

Saniona is a biotech company developing pharmacological therapies targeting dysfunctions in the brain, with a focus on CNS drug development and clinical advancement programs.

BiotechHealthtechMedical DevicesCopenhagen, DK

Thomas Feldthus(Co-founder and CEO)Janus Schreiber Larsen(Chief Operational Officer)Karin Sandager Nielsen(Chief Scientific Officer)

BiotechDigital HealthMedical DevicesSeattle, US

PAPeter A. Thompson(Executive Officer, Director)in

Co-investorsECEcoR1 CapitalRARA CapitalUSUS Venture PartnersNENextech Invest

Step Pharma develops oral cancer drugs that inhibit the enzyme cytidine triphosphate synthase 1 (CTPS1), with its lead therapeutic dencatistat in clinical development for lymphoma, solid tumors, and essential thrombocythaemia.

BiotechDeep TechMedical DevicesSaint-Genis-Pouilly, FR

Alain Fischer(Founding Scientist)

Co-investorsHAHadean VenturesKUKurma PartnersBPBpifranceSUSunstone CapitalV-V-Bio Ventures

StrideBio develops gene therapies based on its STRIVE AAV capsid platform, targeting people with life-threatening diseases.

BiotechHealthtechDurham, US

AAAravind Asokan(Director)inMAMavis Abjandje-McKenna(Director)RSRichard Smith(Executive Officer)inPatrick Ritschel(Executive Officer, Director, Promoter)

Co-investorsABAbingworthHAHatteras Venture Partners

Sweetch provides AI-driven personalized behavioral interventions that help patients manage chronic conditions through continuous engagement and adaptive recommendations.

AI & Machine LearningDigital HealthHealthtech

Co-investorsENEntrée CapitalLILionBirdTATal VenturesTETenmileOUOurCrowd

Theseus builds robotic situational awareness software using visual positioning for drones that operate in GPS-denied environments.

Advanced ManufacturingAI & Machine LearningDefense TechHardwareRoboticsSan Francisco, US

ILIan Laffey(Founder)inSLSacha Lévy(Founder)in

Co-investorsY Y CombinatorANAntlerFIFirst Round CapitalFOForesite CapitalLOLongitude CapitalLULux Capital+4 more

BiotechCambridge, US

William C. Shakespeare(Director)in

BoardIDIain Dukes(Executive Officer, Director)inMRMichael Rome(Director)inCGCarl Gordon(Director)in

Co-investorsFOForesite CapitalLOLongitude CapitalNENextech InvestNENexTech VenturesOROrbiMedRORock Springs Capital+1 more

V-Wave Medical develops a percutaneous implantable shunt device for treating chronic heart failure patients.

BiotechHealthtechMedical DevicesIsrael, IL

Co-investorsAPAPERTURE Venture PartnersBRBRM CapitalTRTriventures

Vanqua Bio is a biotechnology company developing molecules intended to become medicines for neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, and related neurological conditions.

BiotechDeep TechHealthtechLongevityChicago, US

JSJim Sullivan(CEO)inKHKevin Hunt(CSO)in

Co-investorsAVAvoro Capital AdvisorsOROrbiMed

Vascular Graft Solutions develops medical device technologies for coronary revascularization procedures, with a focus on addressing vein graft disease in cardiac bypass surgery.

HardwareHealthtechMedical Devices

Eyal Orion(Founder & Active Chairman)in

Co-investorsBRBroadview VenturesGEGEOCTATal Ventures