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Cancer Focus

Venture capitalActively deployingoperating company · company profile

Houston · Pre-Seed–Seed · 4 people tracked

Also known as BIG VENTURES MANAGEMENT COMPANY, LLC

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Investment thesis

Cancer Focus Fund invests in oncology therapeutics — including immunotherapies, CAR-T and cell therapies, precision medicine and radiotherapeutics — that are approaching human clinical trials. Leveraging a unique relationship with MD Anderson Cancer Center, the fund sources oncology assets globally and uses a Scientific Advisory Committee of MD Anderson experts to identify candidates ready for trials. Its leadership then applies rigorous risk/reward analysis to select only a few drugs worthy of investment. The fund pairs decades of venture capital experience with MD Anderson's research and clinical-trial expertise, aiming to generate returns for investors while advancing breakthroughs for cancer patients.

Source: firm website, verified Sep 29, 2026.

Stage
Pre-Seed–Seed
HQ
Houston, Texas, US
Instruments
Equity
Founded
2019
Last 12 months
1 investment
Private fund assets
$147.9M
VC funds
5
Tracked investments
11
IPOs
1

Team · 4 people

from the firm's website & public directories
Michael Margolis· Capital Markets Advisor

Head of Life Sciences and Co-Head of Healthcare Investment Banking at Oppenheimer & Co.

What they invest in

from 7 of 11 portfolio companies

Biotech ×6Medical Devices ×3Healthtech ×2AgTech ×1Deep Tech ×1

HQs:United States×5United Kingdom×1Israel×1

Investments · 11 tracked

founders shown can be your intro path

By year:2026 · 12024 · 12023 · 12020 · 12016 · 15 dated

Mereo BioPharma Groupmereobiopharma.cominNASDAQ: MREOJun 2020

Mereo BioPharma is a biopharmaceutical company publicly traded on Nasdaq under the ticker MREO.

BiotechHealthtechLondon, GB

John Richard(Head of Corporate Development and Co-Founder)inCharles Sermon(General Counsel and Co-Founder)Richard Jones(Chief Financial Officer)inJill Henrich(Senior Vice President)inDenise Scots-Knight(Chief Executive Officer)in

BoardDr. Deepa Pakianathan(Non-Executive Director)

Co-investorsPontifax Venture CapitalVivo CapitalWoodford Investment Management

NectinTxnectintx.com✓ verified

Nectin Therapeutics develops novel monoclonal antibodies and antibody-drug-conjugates to treat difficult-to-treat cancers by targeting immune evasion mechanisms.

BiotechDeep TechMedical Devices

Co-investorsPeregrine VenturesIsrael Biotech Fund

ImmunoGenesisimmunogenesis.comin

ImmunoGenesis is a clinical-stage immuno-oncology biopharmaceutical company developing immune therapies for immune-excluded tumors, which resist standard PD-1 blockade.

BiotechHealthtechMedical DevicesDoylestown, US

Michael A. Curran(Director)inJennifer Barlow(Executive Officer, Director)Clifford Stocks(Director)James Barlow(Executive Officer, Director)Jeremy Barton(Executive Officer)Federica O'Brien(Executive Officer)

Co-investors3Spoke CapitalAdit Ventures Management, LlcAngel Physicians FundBioAdvanceService Provider CapitalTexas HALO Fund

ISA Pharmaceuticalsisa-pharma.comJan 2023

Netherlands-based developer of fully synthetic immune therapies against cancer and persistent viral infections using a synthetic long peptide platform.

Co-investorsInvest-NLRegeneron Ventures

Kahrkahrbio.com

Uses proprietary technology to unmask cancer and recruit a targeted immune response.

Co-investorsaMoonPeregrine Ventures

March Biosciencesmarch.bioin

March Bioscience is a cell therapy company assembling leading scientists and drug developers to advance cell therapy treatments.

BiotechMedical DevicesHouston, US

Sarah Hein(CEO, Co-Founder)inMaksim Mamonkin(Co-Founder, Chair Scientific Advisory Board)Malcolm Brenner(Co-founder)

BoardThomas Luby(Director)inPeter Olagunju(Director)inJoseph Petrosino(Director)

Co-investorsMission Biocapital4BIO CapitalCancer FundFitz Gate VenturesModi VenturesPortal Innovations+2 more

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Southeast Venture HoldingsEisbach BioMolecular ImagingNectin TherapeuticsStarget Pharma

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Exits · 1

1 IPOs

Mereo BioPharma GroupNASDAQ: MREO

Frequently asked questions

How many investments has Cancer Focus made?
Cancer Focus has 11 tracked investments, 1 of which have exited, including 2 dated in the last 24 months.
What stage does Cancer Focus invest at?
Cancer Focus invests at the Pre-Seed, Seed stages.
What sectors does Cancer Focus focus on?
Cancer Focus focuses on Biotech, Digital Health, Healthtech, Medical Devices.
Where is Cancer Focus located?
Cancer Focus is headquartered in Houston, US.
Who does Cancer Focus co-invest with?
Cancer Focus most often shares deals with aMoon, Adit Ventures Management, Llc, Cancer Fund, among 16 tracked co-investors.

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