Fundraising Fox
Route 66 Ventures
Venture capitalAlexandria · Pre-Seed–Growth · 9 people tracked
Also known as Route 66
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Investment thesis
Route 66 Ventures invests in founders using technology to solve meaningful problems and create positive change. Positioning themselves as investors, owners, and operators who have founded and built multiple companies, the firm leverages its operating experience to add value across all stages of a company's growth. Since 2014, it has completed over 500 transactions and deployed more than $550M in capital, achieving dozens of exits while maintaining numerous active investments. The firm's stated investment focus areas are digital health and wellness and financial technology.
Source: firm website, verified Sep 25, 2026.
Team · 9 people
from the firm's website & public directories
Founder mafia
2 people who came through Route 66 Ventures went on to found or lead other companies.
What they invest in
from 41 of 72 portfolio companiesSaaS ×15Fintech ×14Healthtech ×14Digital Health ×13Enterprise Software ×12AI & Machine Learning ×10Biotech ×5InsurTech ×5
HQs:United States×27United Kingdom×6Switzerland×1Germany×1Singapore×1
Who they back
founder profiles across 21 portfolio companiesFounding team size:solo founder×112 founders×84+ founders×2
Where their founders studiedfrom 20 founders with education data
University of California, Berkeley ×2
What their founders studiedfrom 17 founders with field-of-study data
Computer Science ×5Engineering ×5Business & Management ×4Finance & Accounting ×4
Where their founders worked beforefrom 21 founders with career history
Entheos Labs ×2Massachusetts General Hospital ×2
Investments · 72 tracked
founders shown can be your intro pathBy year:2025 · 32023 · 32022 · 42021 · 52020 · 22019 · 22018 · 22015 · 223 dated
SoFi Technologies is a digital personal-finance company offering student and personal loans, mortgages, investing, banking and credit cards through one app; it went public on the Nasdaq in 2021 via SPAC.
Anthony Noto(Chief Executive Officer and Director)inChristopher Lapointe(Chief Financial Officer)Arun Pinto(Chief Risk Officer)Jeremy Rishel(Chief Technology Officer)
Co-investorsAlpha Square GroupBaseline VenturesBling CapitalBlue Lion GlobalCanvas VenturesCianna Capital+38 more
AccessPay provides bank integration and data transformation software designed for finance and treasury leaders to modernize banking operations, reduce fraud risk, and improve cash visibility.
Enterprise SoftwareFintechSaaSManchester, GB
Ali Moiyed(Founder)inAnish Kapoor(Former CEO)inJohan Jardevall(CEO)in
Co-investorsAccel-KKRBeringeaNatWestTrue VenturesBeringea ProVen VCT
NourishedRx operates a data-driven "Food is Health" platform that pairs clinically guided nutrition plans with support from Registered Dietitians, Health Coaches, and Wellness Associates to address chronic conditions, maternal health, surgical recovery, and nutrition insecurity.
Digital HealthFoodTechHealthtech
Lauren Driscoll(Founder & CEO)in
Co-investorsConnecticut InnovationsPrimetime PartnersS2G InvestmentsHDS CapitalPeakBridge VC
Switchboard Health provides software that modernizes the specialty care referral process, using data sets, a virtual care network, and matching algorithms to connect patients with specialty care options.
AI & Machine LearningDigital HealthHealthtechSaaSBoise, US
Derek Baird(CEO)in
BoardBenjamin E. B. Britt(Director)inJonathan Philips(Director)Jonathan Phillips(Director)
Board seatBenjamin BrittArif SorathiaRyan Katz· per SEC Form D
Co-investorsA1 Health VenturesHeadwater VenturesCapital ElevenFirst Trust Capital Partners
Bunker Insurance provides commercial insurance for small businesses, freelancers, and independent professionals, offering tailored policies and usage-based insurance (UBI) with short-term coverage matching contract lengths.
FintechFuture of WorkInsurTech
Co-investorsClocktower VenturesComcast VenturesLaunchCapitalAlpine VenturesAmerican Family VenturesOmidyar Network
Canvas Medical develops a customizable and extensible electronic medical record (EMR) platform for ambulatory clinics, featuring developer tools, APIs, and AI capabilities like clinical co-pilots to automate workflows in scheduling, charting, and billing.
AI & Machine LearningDigital HealthHealthtechMedical DevicesSaaS
Andrew Hines(Founder)in
Co-investorsEnsemble LabsInspired CapitalUpfront VenturesVillage GlobalWestern Technology InvestmentHaystack+4 more
Change Foods uses precision fermentation with microbes to produce real dairy proteins, fats, and flavors without cows, then applies traditional cheesemaking techniques to make animal-free cheese that tastes, stretches, and melts like conventional dairy cheese.
BiotechClimate TechFoodTechPalo Alto, US
David Bucca(Founder)in
Co-investorsAngelCentralBetter Bite VenturesBlue Horizon CorporationClear Current CapitalGGFGreen Generation Fund+2 more
Clearmatics designs protocols and blockchain-based platforms for peer-to-peer exchange and settlement of tokenised value in decentralised markets, serving trading communities.
Crypto & Web3Data & InfrastructureDeep TechEnterprise SoftwareFintechLondon, GB
Robert Sams(Founder)in
Co-investorsNycaNyca Partners
Insurance comparison (AngelPad #2).
Keith Moore(Founder)in
Co-investorsAngelPadBlumberg CapitalBullpen CapitalCore Venture CapitalAmerican Family VenturesCore Innovation Capital+2 more
DriveWealth offers an API-based Brokerage-as-a-Service platform that lets banks, broker-dealers, asset managers, digital wallet providers, and consumer brands embed securities trading and investing for their end clients.
Developer ToolsEnterprise SoftwareFintechSaaSJersey City, US
Robert Cortright(Executive Officer, Director)inMichael Dugan(Executive Officer, Director)inRobert S. Cortright(Founder)
Co-investorsAccelFenway Summer VenturesMiddlegame VenturesMouro CapitalPoint72 VenturesRaptor Group+6 more
EarthOptics measures soil health for farmers and landowners using field sensors and lab analysis to assess soil's physical, chemical, and biological properties.
AgTechAI & Machine LearningClimate TechData & InfrastructureDeep TechArlington, US
Lars Dyrud(CEO)inTodd Martin(Executive Officer)inStephanie Landa(Executive Officer)inHunt Bowers(Executive Officer)inAdam Gerson(Executive Officer)inJohn Dombrosky(Executive Officer, Director)
Co-investorsArgonautic VenturesCerity Partners VenturesCIBUS ENTERPRISE FUND II LPDoon CapitaliSelect FundMiddleland Capital+8 more
Flume brings transparency to material sourcing and procurement in construction, helping teams plan, compare options, and control costs.
AI & Machine LearningB2B MarketplacesConstruction TechSan Luis Obispo, US
James Fazio(Executive Officer, Director)Eric Adler(Executive Officer, Director, Promoter)
BoardSonali Vijayavargiya(Director)in
Co-investorsAugment VenturesHCAP PartnersTranspose Platform ManagementAccompliceCrosslink CapitalFounder Collective+2 more
Flume Health provides AI-powered solutions for healthcare insurance operations, including tools for claims processing, care management, underwriting, and regulatory compliance automation.
AI & Machine LearningHealthtechInsurTechScarsdale, US
Cedric Kovacs-Johnson(Founder)in
Co-investorsCrosslink CapitalEntrepreneurs Roundtable Accelerator (ERA)Founder CollectiveOptum VenturesPrimary Venture PartnersRemarkable Ventures+3 more
Gilgamesh Pharmaceutical develops novel chemical entities for psychiatric disorders using medicinal chemistry and AI-powered translational platforms to design rapid-acting therapies targeting neurobiological mechanisms rather than symptom management.
AI & Machine LearningBiotechDigital HealthHealthtechNew York City, US
Jonathan Sporn(Founder)inAndrew Kruegel(Founder)inDalibor Sames(Founder)inAndrew Kruegel, Ph.D.(Executive Officer)Thomas Kevin Murphy, Ph.D.(Executive Officer)
Co-investorsAera VCAlumni VenturesFrontera Technology VenturesFrontier Path VCJames Beshara FundJLS+25 more
A dairy-free plant-based protein shake brand that sells nutritional beverages for consumers seeking plant-based alternatives to traditional protein products.
ConsumerDirect to ConsumerFoodTechWellness & Fitness
Co-investorsLever VCBig Idea VenturesKale UnitedNucleus CapitalPresight CapitalStray Dog Capital
HomeCare.com connects families with caregivers to provide in-home care and companionship for elderly loved ones.
Digital HealthHealthtechMarketplaces
Co-investors3TS Capital Partners
Hydrogen is a modular, no-code platform for embedded finance that lets companies build and offer financial products and services.
Developer ToolsEnterprise SoftwareFintechSaaS
Matthew Kane(CEO)in
Co-investorsFlucas VenturesVU Venture PartnersSixThirty Ventures
Inflow is an app-based program providing personalized coaching, strategies, and tools to help people with ADHD manage their condition.
BiotechConsumerDigital HealthHealthtechMental HealthSaaSLondon, GB
Levi Epstein(Founder)inSeb Isaacs(Founder)in
Co-investorsHoxton VenturesOctopus VenturesY CombinatorAntlerITERATIVELEAP Global Partners+4 more
Advanced ManufacturingConsumer
Co-investors500 GlobalAntlerAppWorks VenturesHoxton VenturesITERATIVESpiral Ventures+1 more
Infrascale provides cloud-based data protection with backup and disaster recovery solutions, offering offsite data storage and standby infrastructure for real-time recovery.
Cloud ComputingCybersecurityData & InfrastructureEnterprise SoftwareEl Segundo, US
KENNETH SHAW, JR.(Executive Officer, Director)Ken Shaw(Founder of Safe Offsite Pty Ltd)inMICHAEL BELL(Executive Officer)inHARDY PARUNGAO(Executive Officer)inRob Peterson(Chief Executive Officer)inAndrew Evers(Chief Technology Officer)in
Co-investorsCarrick Capital PartnersMontage Capital
Joon provides app-based 1-1 online therapy delivered by licensed therapists for youth ages 13-26 and their families.
Digital HealthHealthtechMental Health
Emily Pesce(CEO)
Co-investorsPioneer Square LabsCity Light
Joon builds an autonomous AI workforce for cyber defense, deploying AI "workers" that operate security operations within a customer's own environment rather than tools a team operates.
AI & Machine LearningCybersecurityEnterprise Software
Co-investorsMantis Capital
Joon is a mobile app that helps children ages 6-12 build executive functioning and positive habits through gamified task management, targeting parents seeking to reduce behavioral friction around chores, homework, and daily routines.
ConsumerDigital HealthEdTechHealthtechWellness & FitnessSan Francisco, US
Isaac Eaves(Founder)inBrad Brenner(Founder)inKevin Bunarjo(Founder)in
Co-investorsBlue Lion GlobalCathexis VenturesCSVE Venture PartnersFoundersLobster CapitalMaC Venture Capital+7 more
Judopay operates a payments platform that connects businesses to acquirers, open banking services, fraud tools and alternative payment methods across mobile, web and in-app.
FintechSaaS
Knip.ch is a German-language blog publishing articles on Swiss topics such as law, finance, society, real estate, and family life.
Media & Entertainment
Co-investorsFinch CapitalQED Investors
Mine'd is an emotional wellness app connecting users with vetted wellness experts through live and on-demand classes.
Wellness & FitnessNew York City, US
Aaron Albert(Executive Officer, Director)Mark Groves(Executive Officer)Matthew Sadofsky(Director)
BoardJeff Cantalupo(Director)in
Co-investorsSocial StartsTechstarsAble PartnersJoyance PartnersListen VenturesWndrCo
Moneyfarm offers a DIY "Share Investing" service and app that lets retail investors build their own portfolios from UK stocks, ETFs, bonds, and mutual funds, alongside managed portfolio options and research tools including an AI information support tool called Bastian.
FintechSaaSLondon, GB
Co-investorsUnited VenturesEndeavor CatalystM&G
Rockville, US
Al Noshirvani(Executive Officer, Director)inAli Noshirvani(Executive Officer, Director)John Cramp(Executive Officer, Director)inTim Bender(Executive Officer)in
BoardDavid Bosserman(Director)inGary Golding(Director)
Co-investorsEdison PartnersEscalate Capital PartnersSWaN & Legend Venture Partners
Ordaōs uses AI and deep learning through its Design Engine to design novel mini-proteins and protein binders such as nanobodies for drug discovery.
AI & Machine LearningBiotechDeep TechNew York, US
David Longo(Co-Founder & Chief Executive Officer)inMatthias Denecke(Chief Technology Officer)inVictor Bustos(VP of Pre-clinical R&D)inScott Horner(Director)
BoardBenjamin Britt(Director)inUlo Palm(Director)
Co-investorsCitta CapitalIAG Capital PartnersMiddleland Capital
Parsley Health delivers evidence-based, whole-body functional medicine care through board-certified clinicians trained in functional medicine.
Digital HealthHealthtechWellness & FitnessNew York, US
Robin Berzin(Founder)in
Co-investors7wire VenturesAdvance Venture PartnersAlpha EdisonAmplo VenturesBastien Family OfficeCorewell Health Ventures+17 more
Payzer builds an all-in-one software platform for trade contractors covering payments, financing, and business operations from initial customer contact through final payment.
Construction TechEnterprise SoftwareFintechSaaSCharlotte, US
Joe Giordano(Founder)inDouglas Little(Executive Officer)Thomas McCulley(Director)Mark E McDowell(Director)in
BoardBenjamin Britt(Director)inDon Rainey(Director)in
Co-investorsAlerion VenturesAlumni VenturesCharlotte FundElevate Innovation PartnersGray VenturesGrotech Ventures+3 more
Payzerware (now part of WEX FSM) offers an all-in-one field service management software for trade contractors, covering job and crew management, cash flow, payment collection, and customer financing.
Construction TechFintechSaaS
Co-investorsAlerion VenturesFerguson VenturesGrotech VenturesHarbert Growth PartnersIDEA Fund Partners
Quantemplate is a network platform that enables organizations to exchange, reconcile, and orchestrate data across value chains with transparency and trust.
AI & Machine LearningData & InfrastructureEnterprise SoftwareFintechInsurTechSaaSNew York City, US
Adrian Rands(Co-founder)inDaniel Dall'Asta(Director)Caroline Murphy(Executive Officer)Howard Lundgren(Executive Officer, Director)
Co-investorsBallpark VenturesTechstars
Financial platform providing low-cost, short-term liquidity and financial tools to freelancers, independent contractors and small businesses.
HR Tech
John ReinschPaul TipladyTrevor Branon
Co-investors500 GlobalRanch Ventures
Reframe (Reframe Financial / Reframe.care) helps families plan and prepare for the financial issues of aging, with a focus on long-term care financing and home health care needs.
Digital HealthFintechHealthtechInsurTech
Karan Aneja(CEO and Co-Founder)in
Co-investorsAlpha EdisonAV8 VenturesJ-VenturesMS&AD VenturesCubit CapitalEclipse+3 more
Ripple builds blockchain-based financial infrastructure to enable cross-border value transfer and payment solutions for enterprises, governments, and financial institutions.
Crypto & Web3Enterprise SoftwareFintechSan Francisco, US
Ryan Fugger(Founder)Christian Larsen(Executive Officer, Director, Promoter)David Schwartz(Director)inBradley Garlinghouse(Executive Officer)
BoardYoung Guo(Director)Doug Chertok(Director)
Co-investors500 GlobalAbstract VenturesAurum Venture PartnersAvant Global LLCCamp One VenturesCastle Island Ventures+22 more
Ryse Health is a digital care platform for individuals and families managing type 2 diabetes, combining medical support from endocrinologists and behavioral health specialists with technology, coaching, and community resources.
Digital HealthHealthtechWashington, US
Richard Gurley(Executive Officer, Director, Promoter)inErin Kane(Executive Officer, Director, Promoter)
BoardPankaj Jethwani(Director)Eric Dobosh(Director)inRyan Tyner(Director)
Co-investorsW Health Ventures Gp Llc
Sensorium Therapeutics is a clinical-stage biotech company developing novel CNS therapies for anxiety, epilepsy, and cognitive dysfunction using its SensAI platform, which integrates AI, chemistry, and curated natural product data to identify therapeutic patterns from over 50 million biological relationships.
AI & Machine LearningBiotechDigital HealthMedford, US
Jerrold Rosenbaum(Director)inJacob Hooker(Executive Officer, Director)inPranav Tadi(Executive Officer)
BoardRyan Katz(Director)inKevin Lalande(Director)inRichard Simon(Director)
Co-investorsBonaventure Equity, LLCHatteras Venture PartnersIter InvestmentsMission BiocapitalPalo Santo VCService Provider Capital+2 more
Simplesurance is an embedded insurance technology provider that delivers insurance products through B2B and B2C solutions across industries including banking, automotive, e-commerce, travel, and cybersecurity.
Enterprise SoftwareFintechInsurTechSaaSBerlin, DE
Robin von Hein(Managing Director, Founder)inJoachim von Bonin(Managing Director Finance, Co-Founder)in
Co-investorsAllianz XConny & Co.German Startups GroupLA ROCA CapitalRakuten CapitalRheingau Founders+2 more
SoloFire is a sales enablement platform that centralizes approved content, SCORM training, certifications, and AI coaching, with branded, trackable content sharing ("Spaces"), offline access, and a built-in light CRM that syncs engagement data to existing CRM systems.
Marketing TechSaaSSales Tech
Co-investorsSTARTUP IGNITION VENTURES
Tandem is a marketplace that simplifies commercial office space search for companies by consolidating market access, verified pricing and availability, and expert negotiation support in one platform.
B2B MarketplacesEnterprise SoftwareMarketplacesPropTechSaaSSan Francisco, US
Rafi Sands(Founder)inSean Miller(Founder)inBrendan Suh(Founder)inBen Lowenstein(Founder)inChristophe Barre(Founder)in
Co-investorsJ4 VenturesPioneerSoma CapitalThe 23 FundThe MBA FundY Combinator+29 more
FintechNew York, US
Alex Bangash(Executive Officer, Director)in
BoardJeff Webber(Director)
Co-investors500 GlobalDCVC (Data Collective)Hemisphere Ventures LLCThe HiveFounders FundMorado Ventures+1 more
Yuvo Health provides software and business services to help community health centers operate more effectively within value-based care models.
Digital HealthEnterprise SoftwareHealthtechSaaSNew York, US
Cesar Herrera(Chief Executive Officer and Co-Founder)inJanel Sia(Chief Strategy Officer and Co-Founder)Stephanie Hudson(Executive Officer, Director)
BoardFatima Husain(Director)inBrenton Fargnoli(Director)inJoseph Mayer(Director)in
Co-investorsAlleyCorpAV8 VenturesGreyMatterHLM Investment PartnersLifeX VenturesMastry+5 more
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
8 SecuritiesAccordedAuxira HealthBaton LeadsCasinoenligneluxembourgD3 TechnologyDefunkifyDigital Insurance GroupGilgameshHyphen GroupJooncareLuminous SolutionsMassetMaxwellMinedMovenNext CapitalReframe FinancialResonateRiverSunday HealthTillVaamoVemo EducationVital BioYuvo Health
Exits · 8
1 IPOs · 7 acquisitions · showing 6SoFiNASDAQ: SOFI8 Securitiesacq. by Sofi.CoGilgameshacq. by AbbViePayzerwareacq. by WEXTillacq. by Marlette Holdings (Best Egg)Vaamoacq. by Moneyfarm
Portfolio news
latest coverage across their companies
Moneyfarm · blog.moneyfarm.com · Aug 13, 2026
Ripple Labs · finance.yahoo.com · Jul 14, 2026
Parsley Health · trysignalbase.com · Mar 25, 2026
Frequently asked questions
- How many investments has Route 66 Ventures made?
- Route 66 Ventures has 72 tracked investments, 8 of which have exited, including 3 dated in the last 24 months.
- What stage does Route 66 Ventures invest at?
- Route 66 Ventures invests at the Pre-Seed, Seed, Series A, Series B, Growth stages.
- What is Route 66 Ventures's typical check size?
- Route 66 Ventures typically writes checks of $500K – $4M.
- What sectors does Route 66 Ventures focus on?
- Route 66 Ventures focuses on Digital Health, Fintech, Sector Agnostic, Wellness & Fitness.
- Where is Route 66 Ventures located?
- Route 66 Ventures is headquartered in Alexandria, US.
- Who does Route 66 Ventures co-invest with?
- Route 66 Ventures most often shares deals with Alpha Edison, Core Venture Capital, IA Capital Group, among 168 tracked co-investors.
Co-investors · 5
Mouro Capital is a venture capital investor backing early to growth stage companies, leveraging its expertise and global network across multiple regions.
Finch Capital is a European growth equity firm investing in B2B business and financial technology software companies. It provides growth capital and hands-on value creation support to help European-HQ companies scale.
Startup Ignition Ventures is a pre-seed fund backing software and AI founders who show real customer traction and disciplined execution, operating within a broader founder ecosystem that includes a bootcamp and AI-powered tools.
Point72 Ventures is a venture capital firm that backs founders across sectors, providing insight, industry expertise, and network support. Since 2016 it has invested in more than 130 companies.
Anthemis is an investment firm focused on the digital economy, backing companies that reshape financial services and the broader economy for wider benefit.
Firms observed investing alongside Route 66 Ventures, from public investor directories. Shared companies are the overlap with Route 66 Ventures's recorded portfolio.
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