Route 66 Ventures
Venture capitalAlexandria · Pre-Seed–Series A · 9 people tracked
Investment thesis
Route 66 Ventures invests in founders who build technology-driven solutions to meaningful problems. The firm positions itself as investors, owners, and operators whose team has founded and built multiple companies, allowing them to add value at any stage of a company's development and help accelerate business growth. Since 2014, the firm reports completing more than 500 transactions and deploying over $550M in capital, with dozens of exits and numerous active investments in its portfolio.
Source: firm website, verified Aug 3, 2026.
Team · 9 people
from the firm's website & public directories
What they invest in
from 27 of 54 portfolio companiesFintech ×12SaaS ×11Healthtech ×9Digital Health ×8Enterprise Software ×8AI & Machine Learning ×6InsurTech ×5Biotech ×4
HQs:United States×20United Kingdom×3Germany×1
Who they back
founder profiles across 12 portfolio companiesFounding team size:solo founder×92 founders×3
Investments · 54 tracked
founders shown can be your intro pathBy year:2025 · 22023 · 12022 · 12021 · 32019 · 18 dated
NourishedRx operates a data-driven "Food is Health" platform that pairs clinically guided nutrition plans with support from Registered Dietitians, Health Coaches, and Wellness Associates to address chronic conditions, maternal health, surgical recovery, and nutrition insecurity.
Digital HealthFoodTechHealthtech
Lauren(Founder & CEO)Lauren Driscoll(Founder & CEO)in
Co-investorsConnecticut InnovationsPrimetime PartnersS2G InvestmentsHDS CapitalPeakBridge VC
Switchboard Health provides software that modernizes the specialty care referral process, using data sets, a virtual care network, and matching algorithms to connect patients with specialty care options.
AI & Machine LearningDigital HealthHealthtechSaaSBoise, US
Derek Baird(CEO)in
BoardBenjamin E. B. Britt(Director)inJonathan Phillips(Director)
Board seatBen BrittArif SorathiaRyan Katz· per SEC Form D
Co-investorsHeadwater VenturesCapital ElevenFirst Trust Capital Partners
AccessPay provides a cloud-based bank integration platform that connects ERP, payroll, and back-office systems to banks to automate payments, collections, and bank statement retrieval.
Enterprise SoftwareFintechSaaS
Co-investorsAccel-KKRBeringeaBeringea ProVen VCT
HealthtechChicago, US
Inna Plumb(Executive Officer, Director)Matt Hallgren(Executive Officer)
BoardArif Sorathia(Director)inWilliam Sheahan(Director)Todd Johnson(Director)Patricia Morehead(Director)
Co-investorsCity LightDigiTx Partners LLC
Bunker Insurance provides commercial insurance for small businesses, freelancers, and independent professionals, offering tailored policies and usage-based insurance (UBI) with short-term coverage matching contract lengths.
FintechFuture of WorkInsurTech
Co-investorsClocktower VenturesComcast VenturesLaunchCapitalAmerican Family VenturesOmidyar Network
Change Foods uses precision fermentation with microbes to produce real dairy proteins, fats, and flavors without cows, then applies traditional cheesemaking techniques to make animal-free cheese that tastes, stretches, and melts like conventional dairy cheese.
BiotechClimate TechFoodTechPalo Alto, US
David Bucca(Executive Officer, Director, Promoter)
Co-investorsAngelCentralBetter Bite VenturesBlue Horizon CorporationClear Current CapitalGGFGreen Generation Fund
Clearmatics builds protocols and platforms for decentralised markets, drawing on distributed systems, cryptography, consensus protocols, economic mechanism design, and decentralised finance.
Crypto & Web3Deep TechFintech
Co-investorsNycaNyca Partners
Insurance comparison (AngelPad #2).
Keith Moore(Founder)in
Co-investorsAngelPadBlumberg CapitalBullpen CapitalCore Venture CapitalRRE Ventures
Omaha, US
William Fisher(Executive Officer, Director)Merri Wees(Executive Officer)Mark Vipond(Executive Officer, Director)
BoardBen Britt(Director)inAlex Hart(Director)Matthew Lawlor(Director)
Co-investorsFinch Capital
DriveWealth offers an API-based Brokerage-as-a-Service platform that lets banks, broker-dealers, asset managers, digital wallet providers, and consumer brands embed securities trading and investing for their end clients.
Developer ToolsEnterprise SoftwareFintechSaaSJersey City, US
Robert Cortright(Executive Officer, Director)Michael Dugan(Executive Officer, Director)
Co-investorsAccelMiddlegame VenturesMouro CapitalPoint72 VenturesRaptor GroupSenaHill Partners+1 more
EarthOptics measures soil health for farmers and landowners using field sensors and lab analysis to assess soil's physical, chemical, and biological properties.
AgTechAI & Machine LearningClimate TechData & InfrastructureDeep TechArlington, US
Lars Dyrud(CEO)inTodd Martin(Executive Officer)inStephanie Landa(Executive Officer)Hunt Bowers(Executive Officer)inAdam Gerson(Executive Officer)John Dombrosky(Executive Officer, Director)
Co-investorsArgonautic VenturesCerity Partners VenturesDoon CapitaliSelect FundMiddleland CapitalS2G Investments+6 more
Flume Health provides AI-powered solutions for healthcare insurance operations, including tools for claims processing, care management, underwriting, and regulatory compliance automation.
AI & Machine LearningHealthtechInsurTechScarsdale, US
Cedric Kovacs-Johnson(Executive Officer, Director)
Co-investorsCrosslink CapitalEntrepreneurs Roundtable Accelerator (ERA)Founder CollectiveOptum VenturesRemarkable VenturesBlumberg Capital+2 more
Hydrogen is a modular, no-code platform for embedded finance that lets companies build and offer financial products and services.
Developer ToolsEnterprise SoftwareFintechSaaS
Matthew Kane(CEO)
Co-investorsFlucas VenturesVU Venture PartnersSixThirty Ventures
Inflow is an app-based program providing personalized coaching, strategies, and tools to help people with ADHD manage their condition.
BiotechConsumerDigital HealthHealthtechMental HealthSaaSLondon, GB
Levi Epstein(Founder)inSeb Isaacs(Founder)in
Co-investorsOctopus VenturesY Combinator
Infrascale provides cloud-based data protection with backup and disaster recovery solutions, offering offsite data storage and standby infrastructure for real-time recovery.
Cloud ComputingCybersecurityData & InfrastructureEnterprise SoftwareEl Segundo, US
KENNETH SHAW, JR.(Executive Officer, Director)Ken ShawKEN SHAW, JR.(Executive Officer, Director)KEN SHAW(Director)MICHAEL BELL(Executive Officer)HARDY PARUNGAO(Executive Officer)
Co-investorsCarrick Capital PartnersMontage Capital
Joon is a mobile app that turns daily tasks and routines into a game where children care for a virtual pet by completing parent-assigned "Quests," aimed at helping kids build habits, focus, and life skills.
ConsumerDigital HealthEdTechOakland, US
Isaac Eaves(Founder)
Co-investorsBlue Lion GlobalCathexis VenturesBrickyard
Judopay operates a payments platform that connects businesses to acquirers, open banking services, fraud tools and alternative payment methods across mobile, web and in-app.
FintechSaaS
Wellness & FitnessNew York City, US
Aaron Albert(Executive Officer, Director)Mark Groves(Executive Officer)Matthew Sadofsky(Director)
BoardJeff Cantalupo(Director)
Co-investorsSocial StartsTechstarsAble PartnersJoyance PartnersListen VenturesWndrCo
Moneyfarm offers a DIY "Share Investing" service and app that lets retail investors build their own portfolios from UK stocks, ETFs, bonds, and mutual funds, alongside managed portfolio options and research tools including an AI information support tool called Bastian.
FintechSaaSLondon, GB
Co-investorsUnited VenturesEndeavor Catalyst
Rockville, US
Al Noshirvani(Executive Officer, Director)John Cramp(Executive Officer, Director)Pascal Bouvier(Director)Tim Bender(Executive Officer)Ali Noshirvani(Executive Officer, Director)Richard Caro(Director)
Co-investorsEscalate Capital PartnersEdison PartnersSWaN & Legend Venture Partners
Co-investorsAnthemis Venture
Co-investorsFrancisco PartnersIA Capital GroupOak HC/FTVermont Center for Emerging Technologies (VCET)
Ordaōs uses AI and deep learning through its Design Engine to design novel mini-proteins and protein binders such as nanobodies for drug discovery.
AI & Machine LearningBiotechDeep TechNew York, US
David Longo(Co-Founder & Chief Executive Officer)inMatthias Denecke(Chief Technology Officer)inVictor Bustos(VP of Pre-clinical R&D)inScott Horner(Director)
BoardBenjamin Britt(Director)inUlo Palm(Director)
Co-investorsCitta CapitalIAG Capital PartnersMiddleland Capital
Parsley Health delivers evidence-based, whole-body functional medicine care through board-certified clinicians trained in functional medicine.
Digital HealthHealthtechWellness & FitnessNew York, US
Robin Berzin(Founder & CEO)Robin Berzin MD(Founder)in
Co-investors7wire VenturesAdvance Venture PartnersAlpha EdisonAmplo VenturesCorewell Health VenturesEvolution VC Partners+10 more
Payzer builds an all-in-one software platform for trade contractors covering payments, financing, and business operations from initial customer contact through final payment.
Construction TechEnterprise SoftwareFintechSaaSCharlotte, US
Joe Giordano(Founder)inDouglas Little(Executive Officer)Joseph A Giordano(Executive Officer, Director)Thomas McCulley(Director)Mark E McDowell(Director)THomas McCulley(Director)
Co-investorsAlerion VenturesElevate Innovation PartnersGray VenturesGrotech VenturesIDEA Fund PartnersCharlotte Fund
Quantemplate is a network platform that enables organizations to exchange, reconcile, and orchestrate data across value chains with transparency and trust.
AI & Machine LearningData & InfrastructureEnterprise SoftwareFintechInsurTechSaaSNew York City, US
Adrian Rands(Director)Daniel Dall'Asta(Director)Caroline Murphy(Executive Officer)Howard Lundgren(Executive Officer, Director)
Co-investorsBallpark VenturesTechstars
Reframe Financial helps families prepare for the financial issues of aging, with a focus on long-term care and caregiving costs.
FintechHealthtechInsurTech
Karan Aneja(CEO & Co-Founder)
Co-investorsAlpha EdisonAV8 VenturesJ-VenturesSixThirty Ventures
Ripple builds blockchain-based financial infrastructure to enable cross-border value transfer and payment solutions for enterprises, governments, and financial institutions.
Crypto & Web3Enterprise SoftwareFintechSan Francisco, US
Ryan Fugger(Founder)David Schwartz(Director)inSusan Athey(Director)Gene Sperling(Director)Christian Larsen(Executive Officer, Director, Promoter)Young Guo(Director)
Co-investors500 GlobalAbstract VenturesAurum Venture PartnersAvant Global LLCCamp One VenturesCastle Island Ventures+19 more
Ryse Health is a digital care platform for individuals and families managing type 2 diabetes, combining medical support from endocrinologists and behavioral health specialists with technology, coaching, and community resources.
Digital HealthHealthtechWashington, US
Richard Gurley(Executive Officer, Director, Promoter)Erin Kane(Executive Officer, Director, Promoter)
BoardPankaj Jethwani(Director)Eric Dobosh(Director)inRyan Tyner(Director)
Co-investorsW Health Ventures Gp Llc
Sensorium Therapeutics is a clinical-stage biotech company developing novel CNS therapies for anxiety, epilepsy, and cognitive dysfunction using its SensAI platform, which integrates AI, chemistry, and curated natural product data to identify therapeutic patterns from over 50 million biological relationships.
AI & Machine LearningBiotechDigital HealthMedford, US
Jerrold Rosenbaum(Director)inJacob Hooker(Executive Officer, Director)inPranav Tadi(Executive Officer)
BoardRyan Katz(Director)inKevin Lalande(Director)inRichard Simon(Director)
Co-investorsBonaventure Equity, LLCHatteras Venture PartnersIter InvestmentsMission BiocapitalService Provider CapitalSante Health Ventures
Simplesurance develops technology that enables businesses to embed insurance products into their offerings.
FintechInsurTechSaaS
Co-investorsAllianz XGerman Startups GroupLA ROCA CapitalRheingau FoundersTempoCapODDO BHF+1 more
Income-based student financing platform helping higher education institutions offer flexible and personalized financing models.
Co-investorsTFX Capital
Yuvo Health provides software and business services to help community health centers operate more effectively within value-based care models.
Digital HealthEnterprise SoftwareHealthtechSaaSNew York, US
Cesar Herrera(Chief Executive Officer and Co-Founder)inJanel Sia(Chief Strategy Officer and Co-Founder)Stephanie Hudson(Executive Officer, Director)
BoardFatima Husain(Director)inBrenton Fargnoli(Director)inJoseph Mayer(Director)in
Co-investorsAlleyCorpAV8 VenturesGreyMatterHLM Venture PartnersLifeX VenturesMastry+3 more
Portfolio news
latest coverage across their companies
Moneyfarm · blog.moneyfarm.com · Aug 13, 2026
Joon · techfundingnews.com · Jul 31, 2026
Ripple Labs · cryptonews.net · Jul 18, 2026
Flume Health · fortuneindia.com · Jul 17, 2026
Bunker · maill.usashooting.org · Apr 29, 2026
Yuvo · startupintros.com · Apr 14, 2026
Parsley Health · trysignalbase.com · Mar 25, 2026
Frequently asked questions
- How many investments has Route 66 Ventures made?
- Route 66 Ventures has 47 tracked investments, including 1 dated in the last 24 months.
- What stage does Route 66 Ventures invest at?
- Route 66 Ventures invests at the Pre-Seed, Seed, Series A stages.
- What is Route 66 Ventures's typical check size?
- Route 66 Ventures typically writes checks of $500K – $4M.
- What sectors does Route 66 Ventures focus on?
- Route 66 Ventures focuses on Digital Health, Fintech, Sector Agnostic, Wellness & Fitness.
- Where is Route 66 Ventures located?
- Route 66 Ventures is headquartered in Alexandria, US.
- Who does Route 66 Ventures co-invest with?
- Route 66 Ventures most often shares deals with Alpha Edison, Accel, Blumberg Capital, among 84 tracked co-investors.
Co-investors · 5
Mouro Capital is a venture capital investor backing early to growth stage companies, leveraging its expertise and global network across multiple regions.
Point72 Ventures is a venture capital firm that backs founders across sectors, providing insight, industry expertise, and network support. Since 2016 it has invested in more than 130 companies.
Anthemis is an investment firm focused on the digital economy, backing companies that reshape financial services and the broader economy for wider benefit.
Finch Capital is a European growth capital investor backing B2B business and financial technology software companies, providing capital and hands-on support across go-to-market, hiring, performance management, M&A and exit planning.
Startup Ignition Ventures (SIV) is a pre-seed fund backing founders who show real customer signal, disciplined execution, and capital-efficient business models, operating within a broader founder ecosystem of education, tools, and community.
Firms observed investing alongside Route 66 Ventures, from public investor directories. Shared companies are the overlap with Route 66 Ventures's recorded portfolio.
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