Route 66 Ventures
Venture capitalAlexandria · Pre-Seed–Series A · 11 people tracked
Investment thesis
Route 66 Ventures invests in founders who build technology-driven solutions to meaningful problems. The firm positions itself as investors, owners, and operators whose team has founded and built multiple companies, allowing them to add value at any stage of a company's development and help accelerate business growth. Since 2014, the firm reports completing more than 500 transactions and deploying over $550M in capital, with dozens of exits and numerous active investments in its portfolio.
Source: firm website, verified Aug 3, 2026.
Team · 11 people
from the firm's website & public directories
What they invest in
from 18 of 53 portfolio companiesHealthtech ×8Digital Health ×7SaaS ×7Fintech ×6AI & Machine Learning ×4Biotech ×4Enterprise Software ×4Climate Tech ×2
HQs:United States×15United Kingdom×2
Investments · 53 tracked
founders shown can be your intro pathNourishedRx provides a data-driven nutrition care platform that connects health plans, providers, and government agencies with clinically guided meal plans and health coaching to address chronic diseases and nutrition insecurity.
Digital HealthFoodTechHealthtech
Switchboard Health provides workflow and data tools for health plans and providers to support specialty care navigation.
Digital HealthHealthtechSaaSBoise, US
Derek Baird(Executive Officer, Director)Arif Sorathia(Director)Benjamin E. B. Britt(Director)Jonathan Phillips(Director)Ryan Katz(Director)
Board seatBenjamin BrittArif SorathiaRyan Katz· per SEC Form D · $4M raise · filed Jun 2025
HealthtechChicago, US
William Sheahan(Director)Inna Plumb(Executive Officer, Director)Todd Johnson(Director)Matt Hallgren(Executive Officer)Patricia Morehead(Director)
BoardArif Sorathia(Director)
Change Foods uses precision fermentation with microbes to produce real dairy proteins, fats, and flavors without cows, then applies traditional cheesemaking techniques to make animal-free cheese that tastes, stretches, and melts like conventional dairy cheese.
BiotechClimate TechFoodTechPalo Alto, US
David Bucca(Executive Officer, Director, Promoter)
Clearmatics builds protocols and platforms for decentralised markets, drawing on distributed systems, cryptography, consensus protocols, economic mechanism design, and decentralised finance.
Crypto & Web3Deep TechFintech
Omaha, US
Alex Hart(Director)Ben Britt(Director)Matthew Lawlor(Director)William Fisher(Executive Officer, Director)Merri Wees(Executive Officer)Mark Vipond(Executive Officer, Director)
DriveWealth is a global B2B financial technology platform offering Brokerage-as-a-Service through APIs, enabling banks, broker dealers, asset managers, digital wallets, and consumer brands to build investing and trading experiences for their end users.
Developer ToolsEnterprise SoftwareFintechSaaS
Robert Cortright(Executive Officer, Director)Michael Dugan(Executive Officer, Director)
EarthOptics builds a machine learning platform and remote-sensing system (GroundOwl and SoilMapper) that maps physical, chemical, and biological soil data to measure compaction, moisture, carbon, and nutrient content.
AgTechAI & Machine LearningClimate TechDeep TechArlington, US
Lars Dyrud(CEO)Todd Martin(Executive Officer)Stephanie Landa(Executive Officer)Hunt Bowers(Executive Officer)Adam Gerson(Executive Officer)John Dombrosky(Executive Officer, Director)
Flume Health provides AI-powered solutions for healthcare insurance operations, including tools for claims processing, care management, underwriting, and regulatory compliance automation.
AI & Machine LearningHealthtechInsurTechScarsdale, US
Cedric Kovacs-Johnson(Executive Officer, Director)
El Segundo, US
MARC McMORRIS(Director)DAN GREGERSON(Director)MICHAEL BELL(Executive Officer)KENNETH SHAW, SR.(Director)KENNETH SHAW, JR.(Executive Officer, Director)HARDY PARUNGAO(Executive Officer)
Rockville, US
David Bosserman(Director)Gary Golding(Director)John Cramp(Executive Officer, Director)Al Noshirvani(Executive Officer, Director)
BoardRyan Katz(Director)
Parsley Health delivers evidence-based, whole-body functional medicine care through board-certified clinicians trained in functional medicine.
Digital HealthHealthtechWellness & FitnessNew York, US
Robin Berzin(Founder & CEO)
Payzer builds an all-in-one software platform for trade contractors covering payments, financing, and business operations from initial customer contact through final payment.
Construction TechEnterprise SoftwareFintechSaaSCharlotte, US
Douglas Little(Executive Officer)Joseph A Giordano(Executive Officer, Director)Thomas McCulley(Director)Benjamin Britt(Director)Don Rainey(Director)Mark E McDowell(Director)
Quantemplate is a network platform that enables organizations to exchange, reconcile, and orchestrate data across value chains with transparency and trust.
AI & Machine LearningData & InfrastructureEnterprise SoftwareFintechInsurTechSaaSNew York City, US
Daniel Dall'Asta(Director)Caroline Murphy(Executive Officer)Adrian Rands(Director)Howard Lundgren(Executive Officer, Director)
Ryse Health is a digital care platform for individuals and families managing type 2 diabetes, combining medical support from endocrinologists and behavioral health specialists with technology, coaching, and community resources.
Digital HealthHealthtechWashington, US
Richard Gurley(Executive Officer, Director, Promoter)Erin Kane(Executive Officer, Director, Promoter)
BoardPankaj Jethwani(Director)Eric Dobosh(Director)Ryan Tyner(Director)
Sensorium Therapeutics is a clinical-stage biotech company developing novel CNS therapies for anxiety, epilepsy, and cognitive dysfunction using its SensAI platform, which integrates AI, chemistry, and curated natural product data to identify therapeutic patterns from over 50 million biological relationships.
AI & Machine LearningBiotechDigital HealthMedford, US
Jerrold Rosenbaum(Director)inKevin Lalande(Director)inRichard Simon(Director)Balkrishan Gill(Director)Alexandra Glucksmann(Director)Jacob Hooker(Executive Officer, Director)in
Income-based student financing platform helping higher education institutions offer flexible and personalized financing models.
Yuvo Health provides software and business services to help community health centers operate more effectively within value-based care models.
Digital HealthEnterprise SoftwareHealthtechSaaSNew York, US
Cesar Herrera(Chief Executive Officer and Co-Founder)Janel Sia(Chief Strategy Officer and Co-Founder)Stephanie Hudson(Executive Officer, Director)Omar Nije(Director)
BoardFatima Husain(Director)Brenton Fargnoli(Director)
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does Route 66 Ventures invest at?
- Route 66 Ventures invests at the Pre-Seed, Seed, Series A stages.
- What is Route 66 Ventures's typical check size?
- Route 66 Ventures typically writes checks of $500K – $4M.
- What sectors does Route 66 Ventures focus on?
- Route 66 Ventures focuses on Digital Health, Fintech, Sector Agnostic, Wellness & Fitness.
- Where is Route 66 Ventures located?
- Route 66 Ventures is headquartered in Alexandria, US.
Co-investors · 5
Point72 Ventures is a venture capital firm that backs founders across sectors, providing insight, industry expertise, and network support. Since 2016 it has invested in more than 130 companies.
Mouro Capital is a venture capital investor backing early to growth stage companies, leveraging its expertise and global network across multiple regions.
Anthemis is a venture capital firm focused on investing in the digital economy, with an emphasis on financial technology and related sectors.
Finch Capital is a venture capital firm focused on European fintech and payments infrastructure, backing companies building an independent European payments ecosystem based on bank rails rather than card networks.
Startup Ignition Ventures (SIV) is a pre-seed fund backing founders who show real customer signal, disciplined execution, and capital-efficient business models, operating within a broader founder ecosystem of education, tools, and community.
Firms observed investing alongside Route 66 Ventures, from public investor directories. Shared companies are the overlap with Route 66 Ventures's recorded portfolio.
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