Route 66 Ventures
Venture capitalPre-Seed–Series A
Investment thesis
Route 66 Ventures backs founders leveraging technology for positive impact on meaningful problems. The firm draws on its team's operational experience from building and founding companies across multiple industries to accelerate portfolio businesses. Since 2014, the firm has completed over 500 transactions and deployed $550M+ in capital.
Source: firm website, verified Jul 21, 2026.
What they invest in
from 5 of 57 portfolio companiesDigital Health ×5Healthtech ×4Biotech ×2SaaS ×2AI & Machine Learning ×1Consumer ×1Enterprise Software ×1FoodTech ×1
HQs:United States×2United Kingdom×1
Investments · 57 tracked
founders shown can be your intro pathNourishedRx provides a data-driven nutrition care platform that connects health plans, providers, and government agencies with clinically guided meal plans and health coaching to address chronic diseases and nutrition insecurity. The company delivers evidence-based food and wellness interventions coordinated by registered dietitians and health coaches to improve population health outcomes.
Digital HealthFoodTechHealthtech
Inflow is an app-based program providing personalized coaching, strategies, and tools to help people with ADHD manage their condition. The platform combines clinical guidance from psychology experts with a supportive community, designed to make mental health support affordable and accessible for neurodiverse individuals.
BiotechConsumerDigital HealthHealthtechMental HealthSaaSLondon, GB
Ryse Health is a digital care platform for individuals and families managing type 2 diabetes, combining medical support from endocrinologists and behavioral health specialists with technology, coaching, and community resources. The company operates in the Baltimore-Washington region and offers remote access to care teams and peer support networks.
Digital HealthHealthtechWashington, US
Sensorium Therapeutics is a clinical-stage biotech company developing novel CNS therapies for anxiety, epilepsy, and cognitive dysfunction using its SensAI platform, which integrates AI, chemistry, and curated natural product data to identify therapeutic patterns from over 50 million biological relationships.
AI & Machine LearningBiotechDigital Health
Yuvo Health provides software and business services to help community health centers operate more effectively within value-based care models. The company works with Federally Qualified Health Centers (FQHCs) to improve financial sustainability, care quality, and patient reach across community markets.
Digital HealthEnterprise SoftwareHealthtechSaaSNew York, US
Cesar Herrera(Chief Executive Officer and Co-Founder)Janel Sia(Chief Strategy Officer and Co-Founder)
Frequently asked questions
- What stage does Route 66 Ventures invest at?
- Route 66 Ventures invests at the Pre-Seed, Seed, Series A stages.
- What is Route 66 Ventures's typical check size?
- Route 66 Ventures typically writes checks of $500K – $4M.
- What sectors does Route 66 Ventures focus on?
- Route 66 Ventures focuses on Sector Agnostic.
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