Epidarex Capital — Full Portfolio

LUNAC Therapeutics develops first-in-class oral and intravenous anticoagulants targeting activated Factor XII to treat and prevent thrombotic events with reduced bleeding risk.

BiotechHealthtechMedical DevicesLeeds, GB

Professor Helen Philippou(Scientific Founder)Dr. Richard Foster(Scientific Founder)

Macomics is a drug discovery company developing therapies that target macrophage activity for diseases with limited or ineffective treatment options.

BiotechLongevity

Co-investorsScottish Enterprise

Nyra Medical develops the CARLEN (Cardiac Leaflet Enhancer) system, a transcatheter single-leaflet device for repairing functional mitral regurgitation while preserving native valve function.

BiotechHealthtechMedical DevicesAtlanta, US

Dr. Murali Padala(Founder)Dr. Eric Sarin(Founder, Director)Dr. Kirthana Suresh(Founder)Sai Muralidhar Padala(Executive Officer, Director)Murali Padala(Co-founder)Eric Sarin(Co-founder)

Co-investorsBroadview VenturesVensana CapitalGRA Venture

Theolytics develops systemically deliverable immunotherapies based on oncolytic adenoviruses designed to target solid tumours and their supporting microenvironment.

BiotechHealthtech

Co-investorsOxford Science EnterprisesSound BioventuresTaiho Ventures, LLCM Ventures

Technology-focused company on rational drug design for cancer and chronic inflammatory diseases (acquired by Aclaris Therapeutics in August 2017).

HealthtechSaint Louis, US

Jennifer Bohnert(Executive Officer)Walter Smith(Executive Officer, Director)Joseph Monahan(Executive Officer, Director)

BoardDaniel Janiak(Director)Charles Bolten(Director)Thomas Smart(Director)

Board seatKyparissia Sirinakis· per SEC Form D

University of Maryland spin-out commercializing minimally invasive image-guided surgical tool for beating heart mitral valve repair (acquired by Edwards Lifesciences in December 2017).

BiotechBaltimore, US

James Gammie(Director)Mark Collins(Executive Officer)Peter Boyd(Executive Officer)William Niland(Executive Officer, Director)

BoardJames Cox(Director)

Board seatKyparissia Sirinakis· per SEC Form D

Slate Bio develops regulatory T cell (Treg) therapies for treating autoimmune diseases.

BiotechDigital HealthMedical DevicesCharlottesville, US

Robert Creeden(Director)Kurt Woerpel(Executive Officer)Andrew J Krouse(Executive Officer, Director)

Board seatKyparissia Sirinakis· per SEC Form D

Co-investorsVTC Ventures

Developing new modulators of the adenosine pathway for cancer treatment.

Co-investorsAvoro Capital AdvisorsF-Prime CapitalKeyhorse CapitalSofinnova VenturesSolasta VenturesvenBio Partners

NASDAQ-listed company developing therapies for complement cascade-driven diseases in haematology, ophthalmology, and nephrology.

Crestwood, US

Co-investorsEMBL VenturesvenBio Partners

University of Glasgow spin-out with pioneering CellOPTIQ technology to evaluate cardiotoxicity risk in pharmaceuticals.

Clyde Biosciences is a contract research organization offering predictive cardiac safety and efficacy testing using human iPSC-derived cardiomyocyte models, aimed at pharmaceutical and biotech teams assessing cardiotoxicity for clinical translation.

BiotechDeep TechHealthtech

Godfrey Smith(Chief Scientific Officer and Co-Founder)Francis Burton(Head of Software and Modeling & Co-Founder)Richard Henderson(Chief Executive Officer)Mark Bryant(Chief Business Officer)

Curve Therapeutics uses its mammalian cell-based Microcycle discovery platform to develop cyclic peptide and small molecule drugs against intracellular targets.

AI & Machine LearningBiotech

Co-investorsPfizer Venture InvestmentsColumbus Venture Partners

Co-investorsBioGeneration Ventures

Dunad Therapeutics is a biotech company developing oral small-molecule medicines using a covalent chemistry discovery platform to target neurodegenerative diseases such as ALS, Parkinson's disease, and FTD.

BiotechDeep TechCambridge, GB

Pearl Huang(President & CEO)Stephen Huhn(CMO)

Co-investorsBGVAlpha Wave Global

University of Edinburgh spin-out clinical-phase biotech developing C-Met molecular targeting technology for cancer radiotherapy and imaging.

Enterprise Therapeutics is a drug discovery company developing therapies for respiratory diseases such as cystic fibrosis, asthma, and COPD.

BiotechHealthtechBrighton, GB

John Ford(Co-founder)Martin Gosling(Founder)

Co-investorsVersant Ventures

Epsilogen develops antibody therapeutics based on the IgE, IgA, and IgG immunoglobulin isotypes for the treatment of cancer, matching each isotype to specific tumor types and combining isotypes into single antibody molecules.

BiotechHealthtech

Tim Wilson(Chief Executive Officer)Kevin FitzGerald(Chief Scientific Officer)Cristina Oliva(Chief Medical Officer)Nick Robbins-Cherry(Chief Financial Officer)Elizabeth Hardaker(Chief Translational Science Officer)

Co-investors3B Future Health FundAlbionVCGlobal BioAccess FundNovartis Venture FundUCL Technology FundBioGeneration Ventures

RNA-targeted company focused on upregulating new targets to transform treatment of neurodegenerative diseases.

The National Kidney Foundation is a nonprofit organization focused on kidney disease, providing patient education, emotional support, and resources for patients, families, living donors, and transplant recipients.

HealthtechImpact & Social Good

Co-investorsYsios CapitalBioGeneration VenturesRoche Venture FundScottish National Investment BankSofinnova Partners

Emory University spin-out developing novel nucleic acid-based targeted delivery platform for cancer therapeutics.

Kodikaz develops Zip-Code, a non-viral cell-specific delivery platform for gene therapy applications, particularly focused on oncology and cancer treatments.

AI & Machine LearningBiotechMedical DevicesAtlanta, US

Anthony Johnson(Co-Founder & CEO)inDr. Leon Bernal-Mizrachi(Co-Founder, CSO)in

Co-investorsGRA VentureIllumina Ventures

University of Edinburgh spin-out immunemetabolic company with expertise in the kynurenine pathway and KMO biology.

Preclinical-stage drug discovery company co-founded by Epidarex-Exeed and Axxam developing first-in-class precision medicines for epileptic and neurological disorders.

Lario Therapeutics develops first-in-class precision medicines aimed at disease-modifying treatments for severe neurological disorders, including developmental and epileptic encephalopathies and Parkinson's disease.

BiotechDeep Tech

Leucid Bio develops CAR-T cell therapies based on a proprietary Lateral CAR platform that redesigns the CAR structure to mimic the lateral signalling arrangement of natural immune receptors.

BiotechHealthtechLondon, GB

John Maher(Founder)

Co-investorsSofinnova PartnersVulpes Investment Management

Libra Therapeutics develops small molecule therapeutics targeting lysosomal function and autophagy to treat neurodegenerative diseases including ALS, Parkinson's, Alzheimer's, and Huntington's disease.

BiotechLongevityMedical Devices

Dr. Gill(Chief Scientific Officer)

Co-investorsDolby Family Ventures

Mironid is a drug development company building a pipeline of therapies targeting cAMP-degrading phosphodiesterase enzymes to treat Autosomal Dominant Polycystic Kidney Disease (ADPKD) and other rare kidney diseases.

BiotechMedical Devices

Adele Rowley(Chief Scientific Officer)

Co-investorsRoche Venture FundSofinnova PartnersBioGeneration VenturesScottish National Investment Bank

NodThera develops clinical-stage small-molecule therapies targeting inflammation for cardiometabolic and neuroinflammatory diseases, including cardiovascular disease, metabolic dysfunction, and neuroinflammation.

BiotechHealthtech

Geoff McDonough(Executive Team / Board)Chris Guiffre(Executive Team)Alan P. Watt(Executive Team)Jyothis George(Chief Medical Officer)Nick Clarke(Executive Team)

Co-investors5AM VenturesF-Prime CapitalSanofi VenturesSofinnova Partners

Medical technology company developing next-generation stroke aspiration technology

Co-investorsHatteras Venture Partners

RapidPulse is a medical device company developing technology for the treatment of ischemic stroke, currently conducting a pivotal clinical study.

BiotechHealthtechMedical Devices

Co-investorsBroadview VenturesHatteras Venture Partners

Ryme Medical develops a catheter-based therapy to treat chronic obstructive pulmonary disease (COPD) by reducing airway inflammation and improving patient outcomes.

BiotechHealthtechMedical DevicesMountain View, US

Co-investorsSeroba Life Sciences

University of Aberdeen spin-out developing nano-synthetic bone graft substitutes using advanced nanostructures for bone repair (acquired November 2020).

Topas Therapeutics develops nanoparticle-based therapies to induce immune tolerance for autoimmune and immune-mediated diseases.

BiotechHealthtech

Hugo Fry(Chief Executive Officer)Christian Schröter(Chief Operating Officer)Cristina de Min(Chief Medical Officer)Anne Burger(Chief Financial Officer)Alex Marshall(Chief Business Officer)

Co-investorsEMBL VenturesBoehringer Ingelheim Venture FundGimvBioMedPartners