Route 66 Ventures — Full Portfolio

AccessPay provides bank integration and data transformation software designed for finance and treasury leaders to modernize banking operations, reduce fraud risk, and improve cash visibility.

Enterprise SoftwareFintechSaaSManchester, GB

AMAli Moiyed(Founder)inAKAnish Kapoor(Former CEO)inJJJohan Jardevall(CEO)in

Co-investorsACAccel-KKRBEBeringeaNANatWestTRTrue VenturesBEBeringea ProVen VCT

NourishedRx operates a data-driven "Food is Health" platform that pairs clinically guided nutrition plans with support from Registered Dietitians, Health Coaches, and Wellness Associates to address chronic conditions, maternal health, surgical recovery, and nutrition insecurity.

Digital HealthFoodTechHealthtech

LDLauren Driscoll(Founder & CEO)in

Co-investorsCOConnecticut InnovationsPRPrimetime PartnersS2S2G InvestmentsHDHDS CapitalPEPeakBridge VC

Switchboard Health provides software that modernizes the specialty care referral process, using data sets, a virtual care network, and matching algorithms to connect patients with specialty care options.

AI & Machine LearningDigital HealthHealthtechSaaSBoise, US

DBDerek Baird(CEO)in

BoardBEBenjamin E. B. Britt(Director)inJonathan Philips(Director)Jonathan Phillips(Director)

Board seatBBBenjamin BrittASArif SorathiaRKRyan Katz· per SEC Form D

Co-investorsA1A1 Health VenturesHEHeadwater VenturesCACapital ElevenFIFirst Trust Capital Partners

Bunker Insurance provides commercial insurance for small businesses, freelancers, and independent professionals, offering tailored policies and usage-based insurance (UBI) with short-term coverage matching contract lengths.

FintechFuture of WorkInsurTech

Co-investorsCLClocktower VenturesCOComcast VenturesLALaunchCapitalALAlpine VenturesAMAmerican Family VenturesOMOmidyar Network

Canvas Medical develops a customizable and extensible electronic medical record (EMR) platform for ambulatory clinics, featuring developer tools, APIs, and AI capabilities like clinical co-pilots to automate workflows in scheduling, charting, and billing.

AI & Machine LearningDigital HealthHealthtechMedical DevicesSaaS

AHAndrew Hines(Founder)in

Co-investorsENEnsemble LabsINInspired CapitalM1M13UPUpfront VenturesVIVillage GlobalWEWestern Technology Investment+4 more

Change Foods uses precision fermentation with microbes to produce real dairy proteins, fats, and flavors without cows, then applies traditional cheesemaking techniques to make animal-free cheese that tastes, stretches, and melts like conventional dairy cheese.

BiotechClimate TechFoodTechPalo Alto, US

DBDavid Bucca(Founder)in

Co-investorsANAngelCentralBEBetter Bite VenturesBLBlue Horizon CorporationCLClear Current CapitalGGGGFGRGreen Generation Fund+2 more

Clearmatics designs protocols and blockchain-based platforms for peer-to-peer exchange and settlement of tokenised value in decentralised markets, serving trading communities.

Crypto & Web3Data & InfrastructureDeep TechEnterprise SoftwareFintechLondon, GB

RSRobert Sams(Founder)in

Co-investorsNYNycaNYNyca Partners

Insurance comparison (AngelPad #2).

KMKeith Moore(Founder)in

Co-investorsANAngelPadBLBlumberg CapitalBUBullpen CapitalCOCore Venture CapitalRRRRE VenturesAMAmerican Family Ventures+2 more

DriveWealth offers an API-based Brokerage-as-a-Service platform that lets banks, broker-dealers, asset managers, digital wallet providers, and consumer brands embed securities trading and investing for their end clients.

Developer ToolsEnterprise SoftwareFintechSaaSJersey City, US

RCRobert Cortright(Executive Officer, Director)inMDMichael Dugan(Executive Officer, Director)inRobert S. Cortright(Founder)

Co-investorsACAccelFEFenway Summer VenturesMIMiddlegame VenturesMOMouro CapitalPOPoint72 VenturesRARaptor Group+6 more

EarthOptics measures soil health for farmers and landowners using field sensors and lab analysis to assess soil's physical, chemical, and biological properties.

AgTechAI & Machine LearningClimate TechData & InfrastructureDeep TechArlington, US

LDLars Dyrud(CEO)inTMTodd Martin(Executive Officer)inSLStephanie Landa(Executive Officer)inHBHunt Bowers(Executive Officer)inAGAdam Gerson(Executive Officer)inJohn Dombrosky(Executive Officer, Director)

Co-investorsARArgonautic VenturesCECerity Partners VenturesCICIBUS ENTERPRISE FUND II LPDODoon CapitalISiSelect FundMIMiddleland Capital+8 more

Flume brings transparency to material sourcing and procurement in construction, helping teams plan, compare options, and control costs.

AI & Machine LearningB2B MarketplacesConstruction TechSan Luis Obispo, US

James Fazio(Executive Officer, Director)Eric Adler(Executive Officer, Director, Promoter)

BoardSVSonali Vijayavargiya(Director)in

Co-investorsAUAugment VenturesHCHCAP PartnersTRTranspose Platform ManagementACAccompliceCRCrosslink CapitalFOFounder Collective+2 more

Flume Health provides AI-powered solutions for healthcare insurance operations, including tools for claims processing, care management, underwriting, and regulatory compliance automation.

AI & Machine LearningHealthtechInsurTechScarsdale, US

CKCedric Kovacs-Johnson(Founder)in

Co-investorsCRCrosslink CapitalENEntrepreneurs Roundtable Accelerator (ERA)FOFounder CollectiveOPOptum VenturesPRPrimary Venture PartnersRERemarkable Ventures+3 more

Gilgamesh Pharmaceutical develops novel chemical entities for psychiatric disorders using medicinal chemistry and AI-powered translational platforms to design rapid-acting therapies targeting neurobiological mechanisms rather than symptom management.

AI & Machine LearningBiotechDigital HealthHealthtechNew York City, US

JSJonathan Sporn(Founder)inAKAndrew Kruegel(Founder)inDSDalibor Sames(Founder)inAndrew Kruegel, Ph.D.(Executive Officer)Thomas Kevin Murphy, Ph.D.(Executive Officer)JSJONATHAN SPORN(Founder)in

Co-investorsAEAera VCALAlumni VenturesAWAwareness VentureFRFrontera Technology VenturesFRFrontier Path VCGAGaingels+26 more

A dairy-free plant-based protein shake brand that sells nutritional beverages for consumers seeking plant-based alternatives to traditional protein products.

ConsumerDirect to ConsumerFoodTechWellness & Fitness

Co-investorsLELever VCBIBig Idea VenturesKAKale UnitedNUNucleus CapitalPRPresight CapitalSTStray Dog Capital

HomeCare.com connects families with caregivers to provide in-home care and companionship for elderly loved ones.

Digital HealthHealthtechMarketplaces

Co-investors3T3TS Capital Partners

Hydrogen is a modular, no-code platform for embedded finance that lets companies build and offer financial products and services.

Developer ToolsEnterprise SoftwareFintechSaaS

MKMatthew Kane(CEO)in

Co-investorsFLFlucas VenturesVUVU Venture PartnersSISixThirty Ventures

Inflow is an app-based program providing personalized coaching, strategies, and tools to help people with ADHD manage their condition.

BiotechConsumerDigital HealthHealthtechMental HealthSaaSLondon, GB

LELevi Epstein(Founder)inSISeb Isaacs(Founder)inBriana Pisauro(Talent Lead)Leo Mahon(Tech Lead)Nafis Khan(Associate)

Co-investorsHOHoxton VenturesOCOctopus VenturesY Y CombinatorANAntlerITITERATIVELELEAP Global Partners+4 more

Advanced ManufacturingConsumer

KLKhanh LêinRaghav M S

Co-investors50500 GlobalANAntlerAPAppWorks VenturesHOHoxton VenturesITITERATIVESPSpiral Ventures+1 more

Infrascale provides cloud-based data protection with backup and disaster recovery solutions, offering offsite data storage and standby infrastructure for real-time recovery.

Cloud ComputingCybersecurityData & InfrastructureEnterprise SoftwareEl Segundo, US

KENNETH SHAW, JR.(Executive Officer, Director)KSKen Shaw(Founder of Safe Offsite Pty Ltd)inMICHAEL BELL(Executive Officer)inHPHARDY PARUNGAO(Executive Officer)inRPRob Peterson(Chief Executive Officer)inAEAndrew Evers(Chief Technology Officer)in

Co-investorsCACarrick Capital PartnersMOMontage Capital

Joon provides app-based 1-1 online therapy delivered by licensed therapists for youth ages 13-26 and their families.

Digital HealthHealthtechMental Health

Emily Pesce(CEO)

Co-investorsPIPioneer Square LabsCICity Light

Joon builds an autonomous AI workforce for cyber defense, deploying AI "workers" that operate security operations within a customer's own environment rather than tools a team operates.

AI & Machine LearningCybersecurityEnterprise Software

Co-investorsMAMantis Capital

Joon is a mobile app that helps children ages 6-12 build executive functioning and positive habits through gamified task management, targeting parents seeking to reduce behavioral friction around chores, homework, and daily routines.

ConsumerDigital HealthEdTechHealthtechWellness & FitnessSan Francisco, US

IEIsaac Eaves(Founder)inBBBrad Brenner(Founder)inKBKevin Bunarjo(Founder)in

Co-investorsBLBlue LionBLBlue Lion GlobalCACathexis VenturesCSCSVE Venture PartnersFOFoundersLOLobster Capital+8 more

Judopay operates a payments platform that connects businesses to acquirers, open banking services, fraud tools and alternative payment methods across mobile, web and in-app.

FintechSaaS

Knip.ch is a German-language blog publishing articles on Swiss topics such as law, finance, society, real estate, and family life.

Media & Entertainment

Co-investorsFIFinch CapitalQEQED Investors

Mine'd is an emotional wellness app connecting users with vetted wellness experts through live and on-demand classes.

Wellness & FitnessNew York City, US

Aaron Albert(Executive Officer, Director)Mark Groves(Executive Officer)Matthew Sadofsky(Director)

BoardJCJeff Cantalupo(Director)in

Co-investorsSOSocial StartsTETechstarsABAble PartnersJOJoyance PartnersLIListen VenturesWNWndrCo

MINED World is an online education company offering recorded and live classes through academies aimed at aspiring entrepreneurs, with a focus on trading and e-commerce skills.

EdTech

Daniel Cueva Rodriguez(Founder & CEO)inEnrique Cueva Valverde(General Manager)César Flores Nazario(Deputy General Manager)

Moneyfarm offers a DIY "Share Investing" service and app that lets retail investors build their own portfolios from UK stocks, ETFs, bonds, and mutual funds, alongside managed portfolio options and research tools including an AI information support tool called Bastian.

FintechSaaSLondon, GB

Giovanni Daprà(Founder)Paolo Galvani(Founder)

Co-investorsUNUnited VenturesENEndeavor CatalystM&M&G

Rockville, US

ANAl Noshirvani(Executive Officer, Director)inAli Noshirvani(Executive Officer, Director)JCJohn Cramp(Executive Officer, Director)inTBTim Bender(Executive Officer)in

BoardDBDavid Bosserman(Director)inGary Golding(Director)

Co-investorsEDEdison PartnersESEscalate Capital PartnersSWSWaN & Legend Venture Partners

Ordaōs uses AI and deep learning through its Design Engine to design novel mini-proteins and protein binders such as nanobodies for drug discovery.

AI & Machine LearningBiotechDeep TechNew York, US

DLDavid Longo(Co-Founder & Chief Executive Officer)inMDMatthias Denecke(Chief Technology Officer)inVBVictor Bustos(VP of Pre-clinical R&D)inScott Horner(Director)

BoardBBBenjamin Britt(Director)inUlo Palm(Director)

Co-investorsCICitta CapitalSTStartXSVSVE CapitalIAIAG Capital PartnersMIMiddleland Capital

Parsley Health delivers evidence-based, whole-body functional medicine care through board-certified clinicians trained in functional medicine.

Digital HealthHealthtechWellness & FitnessNew York, US

RBRobin Berzin(Founder)inDr. Robin Berzin(Founder)

Co-investors7W7wire VenturesADAdvance Venture PartnersALAlpha EdisonAMAmplo VenturesBABastien Family OfficeCOCorewell Health Ventures+18 more

Payzer builds an all-in-one software platform for trade contractors covering payments, financing, and business operations from initial customer contact through final payment.

Construction TechEnterprise SoftwareFintechSaaSCharlotte, US

JGJoe Giordano(Founder)inDouglas Little(Executive Officer)Thomas McCulley(Director)MEMark E McDowell(Director)in

BoardBBBenjamin Britt(Director)inDRDon Rainey(Director)in

Co-investorsALAlerion VenturesALAlumni VenturesCHCharlotte FundELElevate Innovation PartnersGRGray VenturesGRGrotech Ventures+3 more

Payzerware (now part of WEX FSM) offers an all-in-one field service management software for trade contractors, covering job and crew management, cash flow, payment collection, and customer financing.

Construction TechFintechSaaS

Co-investorsALAlerion VenturesFEFerguson VenturesGRGrotech VenturesHAHarbert Growth PartnersIDIDEA Fund Partners

Quantemplate is a network platform that enables organizations to exchange, reconcile, and orchestrate data across value chains with transparency and trust.

AI & Machine LearningData & InfrastructureEnterprise SoftwareFintechInsurTechSaaSNew York City, US

ARAdrian Rands(Co-founder)inDaniel Dall'Asta(Director)Caroline Murphy(Executive Officer)Howard Lundgren(Executive Officer, Director)

Co-investorsBABallpark VenturesTETechstars

Financial platform providing low-cost, short-term liquidity and financial tools to freelancers, independent contractors and small businesses.

HR Tech

John ReinschPaul TipladyTBTrevor Branon

Co-investors50500 GlobalPLPlug and Play VenturesRARanch Ventures

Reframe (Reframe Financial / Reframe.care) helps families plan and prepare for the financial issues of aging, with a focus on long-term care financing and home health care needs.

Digital HealthFintechHealthtechInsurTech

Karan Aneja(CEO and Co-Founder)in

Co-investorsALAlpha EdisonAVAV8 VenturesJ-J-VenturesMSMS&AD VenturesWEWestern Technology InvestmentCUCubit Capital+4 more

Ripple builds blockchain-based financial infrastructure to enable cross-border value transfer and payment solutions for enterprises, governments, and financial institutions.

Crypto & Web3Enterprise SoftwareFintechSan Francisco, US

Ryan Fugger(Founder)Christian Larsen(Executive Officer, Director, Promoter)DSDavid Schwartz(Founder)inBradley Garlinghouse(Executive Officer)Arthur Britto(Founder)Brad Garlinghous(Founder)

Co-investors50500 GlobalABAbstract VenturesAUAurum Venture PartnersAVAvant Global LLCCACamp One VenturesCACastle Island Ventures+22 more

Aravind Mani(Founder)Sai Mattapalli(Founder)Vipin George(Founder)

Co-investorsAMAMD VenturesARArchetypeFOFounders FundLOLowercarbon Capital

Ryse Health is a digital care platform for individuals and families managing type 2 diabetes, combining medical support from endocrinologists and behavioral health specialists with technology, coaching, and community resources.

Digital HealthHealthtechWashington, US

RGRichard Gurley(Executive Officer, Director, Promoter)inErin Kane(Executive Officer, Director, Promoter)

BoardPJPankaj Jethwani(Director)inEDEric Dobosh(Director)inRyan Tyner(Director)

Co-investorsW W Health Ventures Gp Llc

Sensorium Therapeutics is a clinical-stage biotech company developing novel CNS therapies for anxiety, epilepsy, and cognitive dysfunction using its SensAI platform, which integrates AI, chemistry, and curated natural product data to identify therapeutic patterns from over 50 million biological relationships.

AI & Machine LearningBiotechDigital HealthMedford, US

JRJerrold Rosenbaum(Director)inJHJacob Hooker(Executive Officer, Director)inPranav Tadi(Executive Officer)

BoardRKRyan Katz(Director)inKLKevin Lalande(Director)inRichard Simon(Director)

Co-investorsBOBonaventure Equity, LLCHAHatteras Venture PartnersITIter InvestmentsMIMission BiocapitalPAPalo Santo VCSEService Provider Capital+3 more

Simplesurance is an embedded insurance technology provider that delivers insurance products through B2B and B2C solutions across industries including banking, automotive, e-commerce, travel, and cybersecurity.

Enterprise SoftwareFintechInsurTechSaaSBerlin, DE

RVRobin von Hein(Managing Director, Founder)inJVJoachim von Bonin(Managing Director Finance, Co-Founder)in

Co-investorsALAllianz XCOConny & Co.GEGerman Startups GroupLALA ROCA CapitalRARakuten CapitalRHRheingau Founders+2 more

SoloFire is a sales enablement platform that centralizes approved content, SCORM training, certifications, and AI coaching, with branded, trackable content sharing ("Spaces"), offline access, and a built-in light CRM that syncs engagement data to existing CRM systems.

Marketing TechSaaSSales Tech

Co-investorsSTSTARTUP IGNITION VENTURES

Tandem is a marketplace that simplifies commercial office space search for companies by consolidating market access, verified pricing and availability, and expert negotiation support in one platform.

B2B MarketplacesEnterprise SoftwareMarketplacesPropTechSaaSSan Francisco, US

RSRafi Sands(CEO)inSean Miller(CTO)inBSBrendan Suh(Founder)inBen Lowenstein(Product)inCBChristophe Barre(Founder)inAl Harth Al-janaby(Founder)

Co-investorsJ4J4 VenturesMAMaiora Rebel VenturesPIPioneerRERebel FundSOSoma CapitalTHThe 23 Fund+29 more

FintechNew York, US

ABAlex Bangash(Executive Officer, Director)in

BoardJeff Webber(Director)

Co-investors50500 GlobalDCDCVC (Data Collective)HEHemisphere Ventures LLCTHThe HiveWEWestern Technology InvestmentFOFounders Fund+2 more

Yuvo Health provides software and business services to help community health centers operate more effectively within value-based care models.

Digital HealthEnterprise SoftwareHealthtechSaaSNew York, US

CHCesar Herrera(Chief Executive Officer and Co-Founder)inJSJanel Sia(Chief Strategy Officer and Co-Founder)Stephanie Hudson(Executive Officer, Director)

BoardFHFatima Husain(Director)inBFBrenton Fargnoli(Director)inJMJoseph Mayer(Director)in

Co-investorsALAlleyCorpAVAV8 VenturesGRGreyMatterHLHLM Investment PartnersLILifeX VenturesMAMastry+5 more