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LIONHEART VENTURES

Venture capitalActively deployingoperating company · company profile

San Francisco · Seed–Growth · 36 people tracked

Also known as LIONHEART FUND MANAGEMENT LLC

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Investment thesis

Lionheart Ventures backs exceptional, ethical, growth-oriented founders building transformative technologies capable of impacting humanity at scale while delivering strong returns. The firm concentrates on two areas: artificial intelligence that defends and enhances human flourishing, agency, and resilience during a transition it views as more disruptive than the Industrial Revolution; and frontier mental health technologies such as psychedelic medicine and neuromodulation aimed at improving standards of care amid a global mental health crisis. As former founders themselves, the team draws on firsthand company-building experience and a network of expert advisors, prioritizing intellectual honesty, ethical conduct, and counterfactual impact in responsibly stewarding humanity's most powerful technologies.

Source: firm website, verified Sep 29, 2026.

Stage
Seed–Growth
HQ
San Francisco, California, US
Instruments
Equity
Founded
2019
Private fund assets
$59.3M
VC funds
15
Tracked investments
30
Unicorns
2
Acquisitions
1

Team · 36 people

from the firm's website & public directories

Founder mafia

4 people who came through LIONHEART VENTURES went on to found or lead other companies.

What they invest in

from 26 of 30 portfolio companies

Healthtech ×11Biotech ×9AI & Machine Learning ×8Digital Health ×7Mental Health ×7Climate Tech ×6Deep Tech ×5Medical Devices ×5

HQs:United States×15Singapore×2Canada×1United Kingdom×1India×1Norway×1

Who they back

founder profiles across 10 portfolio companies
20%
solo founders
2 of 10 mapped founding teams
35%
repeat founders
of 23 founders with career history

Founding team size:solo founder×22 founders×23 founders×24+ founders×4

Where their founders studiedfrom 19 founders with education data

Stanford University ×3Yale University ×3University of Washington ×2Wesleyan University ×2

What their founders studiedfrom 17 founders with field-of-study data

Physics ×6Computer Science ×5Humanities ×4Economics ×2

Where their founders worked beforefrom 23 founders with career history

OpenAI ×8Google ×4Stanford University ×2Tjuvholmen Ventures ×2

Investments · 30 tracked

founders shown can be your intro path

By year:2025 · 12024 · 22023 · 12022 · 22021 · 32020 · 12019 · 111 dated

Piramidalpiramidal.aiinSeed · Aug 2024✓ verified

Piramidal bridges in-vivo and in-silico intelligence for neuroscience research and clinical applications.

AI & Machine LearningBiotechHealthtechMedical DevicesNew York City, US

Dimitris Fotis Sakellariou(CEO)inKris Pahuja(CPO)inSahil Zubair(Founding Eng)Kyriacos Xanthos(Founding Eng)Yaqub Alwan(Founding Eng)

Co-investorsY CombinatorAdverb Venturesfutureland venturesGeek VenturesRitual CapitalVirta Ventures+11 more

2A Biosciences2abiosci.comin𝕏

2AB BioscienceS develops first-in-class small molecule therapeutics targeting the 5-HT2A receptor for ophthalmology and central nervous system disorders.

BiotechDeep TechDigital HealthEdTechHealthtechMedical DevicesSanta Monica, US

Alex Speiser(Co-Founder & Chief Executive Officer)inCharles Nichols, PhD(Co-Founder & Chief Science Officer)David Nichols, PhD(Co-Founder & Head of Chemistry)Tim Foster, PhD(Co-Founder & Head of Translational Discovery)

BoardGopal Das(Director)

Co-investorsPalo Santo VCTabula Rasa VenturesWhat If Ventures

academia eduacademia.eduFeb 2022

Academia.edu is a commercial San Francisco platform where researchers share, discover and publish academic papers.

San Francisco, US

Richard Price(Founder)in

BoardBijan Sibet(Director)Ben Ling(Director)inAnthony Duffy(Director)

Co-investorsLocalGlobeSDVTeamworthy VenturesTrue Ventures20VCAlumni Ventures+25 more

Anthropicanthropic.comin𝕏

Anthropic is an AI safety research company that builds reliable, interpretable, and steerable AI systems.

AI & Machine LearningDeep TechDeveloper ToolsEnterprise SoftwareSan Francisco, US

Dario Amodei(Founder)inDaniela Amodei(Founder)inTom Brown(Founder)inJack Clark(Founder)inJared Kaplan(Founder)inChris Olah(Founder)in

Co-investors3Comma Capital7BC Venture Capital7GC & CoA.Capital VenturesAccelAkka+151 more

Beamridebeam.comin𝕏

Beam is a shared micromobility operator providing electric scooter services across Asia Pacific cities, committed to climate neutrality and Vision Zero safety standards through technology and rider education programs.

Climate TechMobility & TransportationSingapore, SG

Deb Gangopadhyay(Founder)inAlan Jiang(Founder)inAlan Jiang Deb Gangopadhyay(Founder)

Co-investorsAppWorks VenturesArbor VenturesGobi PartnersIndex VenturesK2 GlobalPartech Ventures+7 more

Bodhibodhi.appin

Bodhi is a mobile app that connects users in India with verified astrologers, tarot readers, and numerologists for online consultations via chat or call.

ConsumerMarketplacesWellness & Fitness

Co-investorsUpsparks Capital

Calmcalm.comApr 2023

Calm is a mental health app offering guided meditations, sleep stories, soundscapes, and stress-relief tools designed to help users manage anxiety, improve sleep, and build healthy habits for overall wellness.

HealthtechMental HealthWellness & FitnessMiami, US

Alex Tew(Founder)inMichael Acton Smith(Founder)inDavid Ko(CEO)

Co-investorsAcumen AmericaBrighter CapitalCherubic VenturesConnect VenturesElefundEQUIAM+25 more

Carbon Crushercarboncrusher.ioin𝕏Seed

Carbon Crusher uses lignin-based materials to recycle existing road surfaces into carbon-negative replacements, removing approximately 1.5 tonnes of CO2 per 100 feet of road.

Advanced ManufacturingCleantechClimate TechConstruction TechOslo, NO

Haakon Brunell(Founder)inHans Arne Flåto(Founder)inKristoffer Roil(Founder)in

Co-investors10xvaluepartnersCollaborative FundLowercarbon CapitalMetaplanetY CombinatorAcequia Capital (AceCap)+3 more

Charm Industrialcharmindustrial.comin𝕏

Charm Industrial converts agricultural residues into bio-oil and injects it underground to remove carbon from the atmosphere at scale.

AgTechCleantechClimate Tech

Shaun Meehan(Founder)inPeter Reinhardt(Founder)inKelly Hering(Founder)Kevin Meissner(Founder)

Co-investorsAENUAzolla VenturesBreyer CapitalCollaborative FundCongruent VenturesGeneral Catalyst+10 more

Clerkenwellclerkenwellhealth.comin

Clerkenwell Health operates specialized clinical trial sites focused on neuropsychiatric and CNS conditions, including psychedelic-assisted therapy research and trials for depression, anxiety, dementia, and neurodegenerative disorders.

BiotechDigital HealthHealthtechMedical DevicesMental HealthLondon, GB

Dr Simon G.D. Ruffell(Principal Investigator & Sub-Investigator)Dr Paul Morrison(Principal Investigator)Dr Henry Fisher(CSO)Tom McDonald(CEO)Sam Lewis(CFO)George McBride(CCO)

Co-investorsExceptional VenturesMoonstone Venture Capital

Cognigenicscognigenics.ioinJun 2022

Cognigenics is developing iRNAi, a non-invasive intranasal RNA interference platform that delivers programmable RNA therapeutics directly to targeted brain circuits, bypassing the blood-brain barrier to modulate mood, memory, and cognition.

BiotechDeep TechDigital HealthEagle, US

John Mee(Mr. Mee is a promoter, director and officer of the company.)J.L. Mee(Founder)inBarry Linder(Executive Officer, Director, Promoter)Dean Radin(Executive Officer, Director, Promoter)

Dendra Systemsdendra.ioSep 2020 · $10MDefunct

World leader in drone-based restoration of degraded land

Matthew Ritchie(Founder)inLauren Fletcher(Founder)Susan Graham(Founder)

Co-investorsAt One VenturesFOUNDER.orgLowercarbon CapitalSystemiq CapitalVentureSouqZouk Capital+5 more

Dimensionsdimensionsretreats.comin𝕏

Dimensions Retreats operates therapeutic retreat centers combining neuroscientific research and evidence-based somatic therapy with luxury accommodations in natural settings, focusing on mental health and well-being.

HealthtechMental HealthTravel & HospitalityWellness & FitnessKingston, CA

Chris(Founder and CEO)

Heart Aerospaceheartaerospace.comin𝕏Seed

Heart Aerospace develops electric regional aircraft for commercial airline operators.

Advanced ManufacturingCleantechClimate TechHardwareSpace TechLos Angeles, US

Anders Forslund(CEO)inKlara Forslund(Founder)Bob Criner(Electric Aircraft Propulsion System Engineer)in

Co-investorsBreakthrough Energy Ventures2am VCAlumni VenturesCastor VenturesKoru CapitalLowercarbon Capital+15 more

Journey Clinicaljourneyclinical.comin𝕏Sep 2021 · $3M

Journey Clinical provides ketamine-assisted psychotherapy (KAP) for depression, anxiety, and PTSD, partnering patients with licensed therapists and medical teams while coordinating with major insurance providers.

Digital HealthMedical DevicesMental Health

Jonathan Sabbagh(Founder)inMyriam Barthes(Founder)in

Co-investorsAble PartnersAlleyCorpCoalition OperatorsFifty YearsFJ LabsMantis Capital+9 more

Journey Colabjourneycolab.comSep 2021 · $12M

Psychedelic therapies for addiction.

BiotechSan Francisco, US

Jeeshan Chowdhury(Executive Officer, Director, Promoter)in

BoardSam Altman(Director)inKrishna Kantheti(Director)

Co-investorsMBX CapitalAPOLLO PROJECTSUprising

Lucid Computinglucidcomputing.aiin

Lucid Computing builds hardware-encrypted compute clusters with verifiable AI audit trails for enterprises and institutions requiring confidentiality and regulatory compliance.

AI & Machine LearningCloud ComputingCybersecurity

Kristian Rönn(Founder)in

Co-investorsJuniper Ventures Management, Llc

Mindstate Design Labsmindstate.designin𝕏Seed · Nov 2024

Mindstate Design Labs is a clinical-stage drug development company that uses AI to map the biological basis of emotion and cognition, synthesizing psychedelic phenomenology and biochemical data to design pharmaceutical compounds that induce specific therapeutic emotional and cognitive states for mental health treatment.

AI & Machine LearningBiotechHealthtechMental HealthSan Francisco, US

Dillan DiNardo(CEO)inTom Ray(Founder)inTegan Johnson(Director of Operations)

BoardRand Hindi(Director)in

Co-investorsARA NEA Ventures (Brand: Dmz.Xyz)Blast.ClubEmpath VenturesImmeasurableInitialized CapitalMetaplanet+14 more

NeuroBionicsneurobionics.ioinJan 2025

NeuroBionics develops soft, flexible neural interface technologies for neuromodulation applications.

BiotechDeep TechHealthtechMedical DevicesSomerville, US

MJ Antonini(Founder, CEO)inNicki Driscoll(Founder, CTO)Polina Anikeeva(Founder)in

Co-investorsDevice of Tomorrow CapitalDolby Family VenturesEmpath VenturesFuture VenturesGreyMatterMana Ventures+4 more

Nuancednuanced.devin𝕏Seed

Nuanced provides a desktop application where AI agents assist software developers by converting preliminary concepts into detailed specifications and maintaining involvement throughout the build process.

AI & Machine LearningConsumerDeveloper ToolsSan Francisco, US

Ayman Nadeem(CEO)inDylan John Drover

Co-investorsAlumni VenturesSterling RoadY CombinatorEight CapitalKleiner PerkinsMaven Ventures+2 more

Pelagopelagohealth.comin𝕏Seed

Pelago is a virtual clinic that partners with employers and health plans to provide substance use disorder treatment and management services.

Digital HealthHealthtechNew York City, US

Yusuf Sherwani(CEO)inSarim Siddiqui(Head of Product)inMaroof Ahmed(Founder)inMaroof AhmedinDr Ashish Mandavia MD(EMEA Commercial Director)inIngrid Kessler(Chief People Officer)

Co-investorsAAF Management Ltd.AtomicoCade VenturesGreyMatterKinnevikKreos Capital+16 more

Reconnect Labsreconnect-labs.comin

Reconnect Labs develops precision neuropsychiatry approaches to treat sleep, anxiety, and addiction disorders, drawing on clinical drug development and psychiatric research.

BiotechDigital HealthHealthtechMental Health

Michael Kometer(Board Chairman & Co-founder)in

Repromptrepromptai.cominSeed

Reprompt builds a digital replica of Earth using AI and location technology.

AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSan Francisco, US

Lukas Martinelli(Founder)inRob Balian(Founder)inWendy Kyle(Head of Recruiting)

Co-investorsMaiora Rebel VenturesRitual CapitalY CombinatorGopher US VentureRebel FundRecursion Ventures+1 more

Shiok Meatsshiokmeats.comin𝕏Seed · Apr 2019Acquired

Shiok Meats grows shrimp and other seafood through cellular agriculture, cultivating animal tissue in laboratories rather than harvesting from wild or farmed sources.

BiotechClimate TechFoodTechHealthtechSingapore, SG

Ling Ka Yi(Founder)inSandhya Sriram(CEO)in

Co-investorsBig Idea VenturesEntrepreneur FirstSustainable Food VenturesVegInvestY CombinatorAera VC+24 more

Softmaxsoftmax.com𝕏

Softmax builds AI systems based on organic alignment principles—the concept that agents remaining aligned with human values also maintain alignment with each other.

AI & Machine LearningDeep TechSector Agnostic

Emmett Shear(CEO & Founder)inDavid Bloomin(Founder)inYatharth Agarwal(Cofounder)inAdam Goldstein(Board Member and Founder Emeritus)

Co-investorsJuniper Ventures Management, LlcLifelike CapitalMythos Ventures Management, LlcNight CapitalSancus VenturesSummit Peak Investments+2 more

Solum Healthgetsolum.cominSeed

Solum provides AI-driven software that automates administrative tasks for healthcare practices, including patient intake, insurance verification, prior authorizations, and scheduling.

AI & Machine LearningHealthtechSaaSSan Francisco, US

JP Montoya(Founder)inNoam Grebler

Co-investorsBAMCAPFundersClubHead & Heart CapitalMaiora Rebel VenturesVentureSouqY Combinator+8 more

Wavepathswavepaths.comin𝕏Oct 2021 · $4.5M

Wavepaths develops adaptive therapeutic music designed to support mental health and wellness practitioners in their sessions.

Digital HealthMental HealthWellness & Fitness

Mendel Kaelen(Founder & CEO)in

Co-investorsMITONReflex CapitalTabula Rasa VenturesEmpath VenturesNeo Kuma VenturesPalo Santo VC

Wright Electricweflywright.comin𝕏Seed

Wright Electric develops high-power-density power systems and inverter generators for defense, aerospace, commercial, and industrial applications.

Advanced ManufacturingClimate TechDefense TechEnergyHardwareSpace TechAlbany, US

Jeff Engler(CEO)inDoug Griswold(Founder)in

Co-investorsAAF Management Ltd.Evergreen Climate InnovationsJude GomilaY CombinatorAgrolimen VenturesEndure Capital+4 more

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Bexson BiomedicalCausative Labs

Portfolio news

latest coverage across their companies

Frequently asked questions

How many investments has LIONHEART VENTURES made?
LIONHEART VENTURES has 30 tracked investments, 1 of which have exited, including 2 dated in the last 24 months.
What stage does LIONHEART VENTURES invest at?
LIONHEART VENTURES invests at the Seed, Series A, Growth stages.
What sectors does LIONHEART VENTURES focus on?
LIONHEART VENTURES focuses on AI & Machine Learning, Biotech, Climate Tech, Healthtech, Mental Health, Mobility & Transportation, Wellness & Fitness.
Where is LIONHEART VENTURES located?
LIONHEART VENTURES is headquartered in San Francisco, US.
Who does LIONHEART VENTURES co-invest with?
LIONHEART VENTURES most often shares deals with Collaborative Fund, Juniper Ventures Management, Llc, Breyer Capital, among 62 tracked co-investors.

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