LIONHEART VENTURES
Actively deployingSan Francisco
Investment thesis
Lionheart Ventures invests in transformative AI and frontier mental health technologies developed by exceptional, ethical founders. The firm believes advanced AI will be more disruptive than the Industrial Revolution and focuses on technologies that defend and enhance human flourishing. In mental health, the firm targets frontier technologies like psychedelic medicine and neuromodulation to improve care standards and address the current mental health crisis. The firm is guided by values of intellectual honesty, ethical conduct, and counterfactual impact.
Source: firm website, verified Jul 20, 2026.
What they invest in
from 6 of 14 portfolio companiesAI & Machine Learning ×3Climate Tech ×2Deep Tech ×2Healthtech ×2AgTech ×1Biotech ×1Cleantech ×1Medical Devices ×1
HQs:United States×2
Investments · 14 tracked
founders shown can be your intro pathPiramidal bridges in-vivo and in-silico intelligence for neuroscience research and clinical applications. The company develops technology that integrates biological data with computational intelligence.
AI & Machine LearningBiotechHealthtechMedical DevicesNew York City, US
Dimitris Fotis Sakellariou(Founder/CEO)inKris Pahuja(Co-Founder/CPO)in
Charm Industrial converts agricultural residues into bio-oil and injects it underground to remove carbon from the atmosphere at scale. The company serves organizations like Stripe, Shopify, and Microsoft seeking carbon removal solutions.
AgTechCleantechClimate Tech
Shaun Meehan(Chief Scientist and co-founder)
Softmax builds AI systems based on organic alignment principles—the concept that agents remaining aligned with human values also maintain alignment with each other. The team conducts research spanning AI safety, multi-agent frameworks, and governance methods.
AI & Machine LearningDeep TechSector Agnostic
Emmett Shear(Founder & Lead)David Bloomin(Founder)Yatharth Agarwal(Cofounder)
Calm is a mental health app offering guided meditations, sleep stories, soundscapes, and stress-relief tools designed to help users manage anxiety, improve sleep, and build healthy habits for overall wellness.
HealthtechMental HealthWellness & Fitness
Anthropic is an AI safety research company that builds reliable, interpretable, and steerable AI systems. The company conducts frontier AI research, applies safety techniques, and deploys systems through products and partnerships.
AI & Machine LearningDeep TechSan Francisco, US
Dario AmodeiDaniela Amodei
Frequently asked questions
- What sectors does LIONHEART VENTURES focus on?
- LIONHEART VENTURES focuses on AI & Machine Learning, Mental Health.
- Where is LIONHEART VENTURES located?
- LIONHEART VENTURES is headquartered in San Francisco, US.
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