National Science Foundation — 2014 Investments

Seattle, US

Jay Goyal(Executive Officer, Director)Deep Sran(Executive Officer, Director)

Co-investorsAtlanta Tech Village

ADViRNA is a contract research provider for oligonucleotide therapeutics, offering design, synthesis, and screening of siRNAs and antisense oligonucleotides along with custom assay development.

BiotechDeep Tech

AIMdyn develops K-GAT (Koopman-based Generative Adaptively-Trained Transformer), a generative AI foundational model that ingests time-stamped data for forecasting, anomaly detection, and optimal decision-making and control.

AI & Machine LearningDeep Tech

Igor Mezic(Co-founder)

Amorphyx develops thin film electronic devices, circuits, and manufacturing processes based on amorphous metals and quantum tunneling, including thin film transistors and nonlinear resistors.

Deep TechNew MaterialsSemiconductors

BiotechWest Lafayette, US

John J. Turek(Executive Officer)David D. Nolte(Executive Officer, Director)Ted Schenberg(Executive Officer)Travis Morgan(Executive Officer)

Co-investorsCentral Texas Angel NetworkThe Launch Place

Apogee Semiconductor designs radiation-hardened, high-performance power semiconductors—including smart high-side power switches and I/O expanders—for space, defense, and high-reliability systems.

Defense TechSemiconductorsSpace TechPlano, US

AppScale provides AWS API-compatible software that lets organizations run AWS workloads' core APIs in their own data centers or private environments at reduced cost.

Cloud ComputingData & InfrastructureEnterprise SoftwareSanta Barbara, US

Woody Rollins(Founder)inEdward C. Rollins, II(Executive Officer, Director)Navraj Chohan(Director)

Aventusoft develops AI-based cardiac and health platforms, including Hemotag for non-invasive cardiac signal analysis, CarePear for connecting patients and physicians with sub-specialists, and Trialogy for AI-driven decentralized clinical trials.

AI & Machine LearningDigital HealthMedical DevicesBoca Raton, US

HealthtechBaltimore, US

Gilmer Blankenship(Executive Officer, Director)Raghu Upender(Executive Officer)Amrit Bandyopadhyay(Executive Officer)Madhvi Upender(Executive Officer, Director)

Biomason uses biotechnology to grow biocement, producing concrete and tile products by using bacteria to bind natural materials as an alternative to Portland cement, aimed at concrete producers and the construction industry.

BiotechClimate TechConstruction TechNew MaterialsResearch Triangle Park, US

Ginger K. Dosier(Executive Officer, Director)Michael F. Noel(Director)John M. Dosier(Executive Officer)

Co-investorsNovo HoldingsCarbonCelesta Capital

Biopico develops the OrganRX™ platform — organ-on-a-chip plates, recirculation systems, and pre-seeded 3D tissue models that recreate human physiology in vitro.

BiotechDeep TechHealthtech

Seattle, US

HOWARD CHIZECK(Executive Officer, Director)DON PICKERING(Executive Officer)ANDREW STEWART(Executive Officer)

Boston Metal develops Molten Oxide Electrolysis (MOE), an electrified process for producing steel and other metals from a range of oxide feedstocks without direct emissions.

Advanced ManufacturingCleantechClimate TechNew MaterialsWoburn, US

Tadeu Carneiro(CEO)inDonald Sadoway(Co-founder (MIT professor))Antoine Allanore(Co-founder (MIT professor))

Co-investorsClimate InvestmentPrelude VenturesBreakthrough Energy VenturesInternational Finance CorporationBMW i VenturesEnergy Impact Partners+8 more

C-Crete Technologies is a materials science company that makes cement-free, ultra-low or negative carbon concrete using natural rocks and industrial by-products as an alternative to Portland cement.

Climate TechConstruction TechNew Materials

Hyperion Biosystems builds diagnostic devices that use computer vision and physics-based algorithms to improve the sensitivity and specificity of point-of-care and at-home tests.

AI & Machine LearningHealthtechMedical Devices

Co-investorsNewlin Investment Company LLCSafar Partners

Co-investorsBling CapitalDCVC (Data Collective)RECODEEDGE

Charles River Analytics develops advanced AI, autonomy, and robotics systems—spanning sensor fusion, perception, and human-robot interaction—for applications including defense, homeland security threat detection, healthcare, and worker safety.

AI & Machine LearningDefense TechRobotics

Co-investorsVertical Venture Partners

Citrine provides an AI platform for product development used across organizations, with expertise in materials discovery and advanced manufacturing optimization.

Advanced ManufacturingAI & Machine LearningDeep TechEnterprise SoftwareNew MaterialsRedwood City, US

Greg Mulholland(Co-founder & CEO)inBryce Meredig(Executive Officer, Director)Rahim Lakhani(Executive Officer)in

BoardScott Brady(Director)inMark Cupta(Director)inAmar Hanspal(Director)

Co-investorsDCVC (Data Collective)DYDX CapitalEndeavor8IsaiISAI GestionPrelude Ventures+4 more

C-Motive develops ZeroMag, an electrostatic motor-drive system that eliminates gearboxes, permanent magnets, and most copper for high-torque, low-speed industrial applications.

Advanced ManufacturingCleantechHardware

Co-investorsAzolla VenturesClean Energy VentureEvergreen Climate InnovationsPrime Impact FundStarlight Ventures

Cycuity provides Radix security analysis and verification tools that detect security weaknesses in semiconductor designs, from IP blocks and RTL to full SoCs with firmware.

CybersecurityDeep TechSemiconductors

Co-investorsIn-Q-Tel

Co-investorsLaunch NY

Electroninks develops metal complex conductive inks for semiconductor packaging, printed circuit boards, consumer electronics, and wearables that achieve conductivities up to 90% of bulk metal at low annealing temperatures.

Advanced ManufacturingNew MaterialsSemiconductorsAustin, US

Co-investorsBandgap VenturesIn-Q-TelM Ventures

College Station, US

John Stockton(Director)Sven Thate(Director)Lars Uffhausen(Executive Officer)Steven Birdwell(Executive Officer, Director)Volker Hammes(Director)Blake Teipel(Executive Officer)

MindFind develops visuotactile measures using eye tracking and machine learning to assess mental functioning, producing reports intended to guide clinical interventions for patients recovering from brain injury and other causes of mental dysfunction.

AI & Machine LearningDigital HealthMedical Devices

Folio Photonics develops multi-layer optical storage media for immutable active data archiving, using materials science to increase storage capacity and lower cost.

Data & InfrastructureDeep TechHardwareNew MaterialsSolon, US

Kenneth D. Singer(Executive Officer, Director)Steven J. Santamaria(Executive Officer, Director)Ronald B. Richard(Director)Robert D. Pavey(Director)Felix Brueck(Director)

Co-investorsCWRU Technology VenturesJobsOhio VenturesMaterial ImpactRefinery VentureForte Ventures

Foundation Instruments builds automated chemical analyzers that measure disinfection by-product concentrations such as trihalomethanes (THM) and haloacetic acids (HAA) in drinking water, aimed at water utilities running real-time monitoring and regulatory compliance programs.

CleantechDeep TechHardware

Secure Open Solutions provides cybersecurity compliance services for defense contractors and small businesses, helping them meet NIST SP 800-171, CMMC, and ITAR requirements.

CybersecurityDefense TechGovTech

Gust provides a platform for startup founders to incorporate their companies, manage cap tables and equity, and handle governance, risk, and compliance.

Enterprise SoftwareFintechFuture of WorkLegalTechSaaSNew York, US

David S. Rose(Executive Officer, Director)in

BoardHoward Morgan(Director)

Co-investors37 AngelsAngels4WomenBeacon AngelsBroad Street AngelsFashion Capital PartnersIU Ventures+8 more

HealthtechMadison, US

Roger Chylla(Executive Officer, Director)Hao Wang(Executive Officer)Praveen Sinha(Executive Officer, Director)Arvind Subramanian(Executive Officer, Director)Thomas Rockwell Mackie(Director)

BoardGreg Robinson(Director)

Co-investorsAscension VenturesBascom Ventures4490 Ventures

Hi-Z Technology designs and manufactures thermoelectric materials, modules, and power-generating systems, including commercial, custom, and miniature modules as well as radioisotope power systems.

Deep TechEnergyHardware

Lexington, US

LYNDON SCOTT STEPHENS(Executive Officer, Director)RAYMOND GRANT STEPHENS(Director)BILLY HARPER(Director)

Co-investorsBluegrass Angel Venture

Imbed Biosciences is a medical device company that develops SAMatrix, an ultra-thin, fully synthetic bioresorbable wound matrix that integrates antimicrobial silver and non-opioid pain agents (lidocaine) for treating chronic and acute wounds such as ulcers, surgical, traumatic, and burn wounds.

BiotechHealthtechMedical DevicesMadison, US

Nicholas L Abbott(Executive Officer, Director)Ankit Agarwal(Executive Officer, Director)

BoardDavid Guinther(Director)Robert A Beckman(Director)

Co-investorsWisconsin Investment Partners

ROIHire is a hiring platform that aggregates candidate information, workforce program data, and predictive analytics to help employers identify available federal and state hiring incentives, estimate retention probability, and project the financial ROI of each candidate.

AI & Machine LearningHR TechSaaS

Intact Solutions develops physics-based simulation software that runs finite element analysis and topology optimization directly on implicit, BREP, mesh, G-code, and CT scan models without meshing or pre-processing, integrating CAD, process, and material data into a single model.

Advanced ManufacturingAI & Machine LearningDeep Tech

Light Optics Technology develops a liquid-lens imaging system that captures sharp two-dimensional images in depth within seconds and combines lateral scans into three-dimensional images in minutes.

Deep TechHardwareMedical Devices

Longevity Biotech develops therapies for neurodegenerative diseases, including a Parkinson's disease candidate (LBT-3627), using its Hybridtide platform and approaches based on immune rebalancing and precision neuroscience.

BiotechDeep TechLongevity

Lygos uses genetically engineered microorganisms to produce industrial chemicals from sugar feedstocks, focusing on compounds where fermentation offers cost advantages compared to fossil fuel-based manufacturing.

Climate TechHealthtechSan Francisco, US

Eric Steen(Founder/CSO)inJeffrey A. Dietrich(Executive Officer, Director)Jay D. Keasling(Director)

BoardLeonard Katz(Director)

Co-investorsFifty YearsFundersClubLG Technology VenturesY Combinator10x FoundersFirst Round Capital+2 more

Microvi is a biotechnology company that develops MicroNiche Engineering (MNE) biocatalyst systems for water and wastewater treatment, including nitrogen, nitrate, phosphorus, and hexavalent chromium removal, as well as industrial bioprocessing applications.

BiotechCleantechClimate TechHayward, US

Fatemeh Shirazi(CEO)Ali Dorri(Executive Officer)Dr. Dirk Brusis(Director)C. Robert Kidder(Director)Hamid Rabie, Ph.D(Director)

Modular Robotics, a Carnegie Mellon University spinoff, makes Cubelets robot blocks that let children build robots from many small modular robots to learn about STEM, coding, and computational thinking.

EdTechHardwareRoboticsBoulder, US

Eric SchweikardtMark D Gross

Co-investorsFoundry

MoJo Labs is an electronic design firm that takes products from concept to market, covering PCB development, firmware, agency certifications, and companion mobile apps.

Deep TechHardwareIoT

Molecular Assemblies uses a Fully Enzymatic Synthesis (FES) technology to produce long, pure, and accurate synthetic DNA oligonucleotides, up to 400 bases, without post-synthesis purification.

BiotechDeep TechNew MaterialsSan Diego, US

J. William Efcavitch, Ph.D.(Treasurer and Chief Scientific Officer)Michael J. Kamdar(President, Chief Executive Officer and Secretary)

BoardDavid Hwang(Director)Larry Stambaugh(Chairman of the Board of Directors)John Nicols(Director)Todd Peterson(Director)

Co-investors11.2 CapitalDCVC (Data Collective)iSelect FundAlexandriaArgonautic VenturesCasdin Capital+2 more

MSTM develops vacuum ionization technologies and multi-ionization source platforms for mass spectrometry, aimed at lowering initial cost, cost per analysis, and required operator expertise.

BiotechDeep TechHardware

N5 Sensors develops cloud-connected, miniature environmental and gas sensors that detect chemical, explosive, and biological hazards for applications in health, military, homeland security, and smart cities.

AI & Machine LearningCleantechDeep TechHardwareIoTRockville, US

Abhishek Motayed(Founder (referenced))

Co-investorsMaryland TEDCOTEDCO

NanoAl develops aluminum alloys and works on equipment and process design as well as metals recycling technology.

Advanced ManufacturingCircular EconomyNew Materials

NanoMedTrix develops multi-modal targeted contrast agents based on mesoporous silica nanoparticles that are visible across MRI, CT, ultrasound, and fluorescence imaging, and that can carry payloads for targeted drug delivery.

BiotechDeep TechMedical Devices

Near Earth Autonomy builds autonomous pilot systems, marketed as "Captain," that let aircraft fly missions with reduced or no onboard crew, certified up to the highest airworthiness standards.

AI & Machine LearningDefense TechRoboticsPittsburgh, US

Sanjiv Singh(Executive Officer, Director, Promoter)Lyle Chamberlain(Executive Officer, Director, Promoter)Sebastian Scherer(Executive Officer, Promoter)Marcel Bergerman(Executive Officer, Director)

BoardCharles Toups(Director)

Co-investorsBoeing HorizonX Ventures

Network Perception offers NP-View, software that generates and maintains network maps to help organizations assess risk, verify network segmentation, and evaluate the security posture of their environments.

CybersecurityEnterprise SoftwareSaaSChicago, US

Robin Berthier(Chief Executive Officer, President, & Director)Ted Greene(Chief Operating Officer)William Sanders(Director)

BoardJeff Bocan(Director)Steve Westly(Director)inRobert Schultz(Director)in

Co-investorsEarly Light VenturesEarth FoundryEnergy FoundryEnergy Impact PartnersIllinois VenturesOkapi Venture Capital+2 more

Advanced ManufacturingCalumet, US

Erik Kiilunen(Executive Officer, Director)Josh Loukas(Director)Dan Ratajczak(Director)David Somero(Director)Steve Williams(Director)Kenneth Keranen(Executive Officer)

NECi builds enzyme-based test kits for detecting nitrate, phosphate, and other contaminants in water quality, environmental monitoring, agriculture, and education settings, and also supplies custom recombinant enzymes in bulk.

AgTechBiotechCleantech

OSI develops DaRRT, an enterprise application for sales and operations planning (S&OP) that companies use to plan production, optimize supply chain networks, and model "what-if" scenarios across weekly to yearly time horizons.

Enterprise SoftwareLogistics & Supply ChainSaaS

Otherlab is an independent research and design lab that develops technologies in renewable energy, robotics, and manufacturing, incubating internal projects into spinout companies.

CleantechEnergyRobotics

Saul Griffith(Founder, Chief Scientist)James McBride(Co-founder, CTO)

PackMaxQ designs and manufactures thermal packaging solutions for cold chain logistics in healthcare and life sciences.

HealthtechLogistics & Supply ChainMedical Devices

Co-investorsPlains Ventures

Parabon develops DNA-based products including software and services for designing synthetic DNA nanostructures (inSēquio Design Studio) and forensic DNA analysis tools that combine genetic genealogy, DNA phenotyping, and kinship analysis (Snapshot) to generate investigative leads for law enforcement.

BiotechDeep TechGovTech

ParaTechs Corporation is a privately held biotechnology company that develops and sells research devices such as the Cervical Manipulation Rod, mNSET Device, and mC&I Device.

BiotechHardware

Predictronics develops AI-based predictive analytics software, centered on its end-to-end PDX platform, for predictive maintenance, predictive quality, and condition-based monitoring of industrial assets.

Advanced ManufacturingAI & Machine LearningIoTCincinnati, US

Edzel Lapira(Co-Founder & CEO)Kelly Campbell(Co-Founder)Patrick Brown(Co-Founder & Chief Revenue Officer)David Siegel(Co-Founder & CTO)Jay Lee(Co-Founder)Atsushi Yoshimoto(Director)

QUASAR develops dry, through-hair EEG sensors and its Dry Sensor Interface (DSI) technology for high-fidelity psychophysiological data acquisition without gels or technicians.

HardwareHealthtechMedical Devices

Deep TechDefense TechHardwareCocoa Beach, US

Mark Tinker(Executive Officer, Director)Freddie Garcia(Executive Officer, Director)Scott Tinker(Director)James McNulty(Director)

Acton, US

Eric Weiss(Executive Officer, Director)Thaddeus Fulford-Jones(Executive Officer, Director)

BoardGabriel Weinberg(Director)

Rebound Tech develops adaptive cooling infrastructure for industrial facilities dealing with high cooling demand, peak energy charges, and humidity control.

CleantechEnergyHardware

Russell Goldfarbmuren(Founder)in

Co-investorsClean Energy VentureClean Energy VenturesiSelect FundSkyview Ventures

Co-investorsElevate Ventures

Sensulin is a preclinical biopharmaceutical company developing glucose-responsive insulin therapies for type 1 and type 2 diabetes that aim to reduce hypoglycemia risk and daily injection requirements.

BiotechMedical Devices

Dan Bradbury(Executive Chairman and Co-Founder)inMike Moradi(CEO)in

BoardAnanth AnnapragadainChristopher Rhodesin

Co-investorsBioBritCortado Ventures

Sensible Solutions develops lithium-based thermal neutron detection systems, including large-area detectors for scalable deployments.

Deep TechDefense TechHardware

Boulder, US

Krista Marks(President and Chief Executive Officer)Sean Kelly(Secretary and Vice President of Engineering)Tom Fischaber(Treasurer and Vice President of Operations)Brent Milne(Vice President of Research)Jeff Ward(Vice President of Product)

BoardJason Mendelson(Director)

SIPPA Solutions builds patient-facing technology that lets individuals securely exchange, consolidate, and manage their personal health data using biometric encryption, turning it into actionable self-management plans.

CybersecurityDigital HealthHealthtech

SkySpecs provides data management and analytics software for renewable energy asset operators, helping them optimize maintenance and operational decisions for wind and solar installations.

AI & Machine LearningCleantechClimate TechEnergySaaSAnn Arbor, US

Daniel Ellis(President and CEO)David Roberts(CEO)Thomas Brady(CFO)Ryan Morton(Chief Technology Officer)Samuel DeBruin(Chief Operational Officer)Patrick Senatore(Director of Engineering)

Co-investorsCapital Midwest FundDakota Venture GroupEvergy VenturesHuron River VenturesID VenturesInvest Michigan+5 more

Spectradyne Particle Analysis builds nanoparticle analyzers using patented microfluidic resistive pulse sensing (MRPS) technology to measure the size and absolute concentration of individual particles in a formulation, with a flagship instrument that adds single-particle fluorescence phenotyping.

BiotechDeep TechHardware

Spero Renewables develops chemical technologies that convert plant-based biomass, particularly lignin, into renewable thermoset plastics and polymers as alternatives to petroleum-based products.

Circular EconomyCleantechNew Materials

Springbok Analytics uses MRI data to measure individual muscle volume, fat infiltration, and symmetry at the individual-muscle level with pixel-level precision.

AI & Machine LearningHealthtechSports TechCharlottesville, US

Joe H(Founder)

Co-investorsAnthropy PartnersCartan CapitalTitletownTech

STF Technologies is a materials testing and consulting company specializing in rheology and soft matter, offering product development support, formulation optimization, and specialized instrumentation for industries including personal care, textile coatings, and polymers/composites.

Deep TechHardwareNew Materials

Tier1 Performance is a consulting partner offering organizational performance and transformation services, covering people development, operations, growth, and digital transformation for businesses.

Enterprise SoftwareFuture of Work

TutorGen builds adaptive learning technology grounded in learning-science research, including its SCALE (Student Centered Adaptive Learning Engine) product.

AI & Machine LearningEdTechSaaS

Vistex Composites is a manufacturing company that developed a patented PFL process for producing advanced thermoset and thermoplastic composite products compatible with carbon fiber, fiberglass, and aramid reinforcements.

Advanced ManufacturingDeep TechNew Materials

Voltaiq offers an AI-powered SaaS platform for the battery industry that collects and harmonizes data across the battery lifecycle, automates anomaly and quality detection, and provides root-cause analysis and natural-language data querying.

AI & Machine LearningCleantechEnergyEnterprise SoftwareSaaSBrooklyn, US

Tal Sholklapper(Co-founder & CEO)inEli Leland(Co-founder & CTO)in

BoardMichael Berolzheimer(Director)in

Co-investorsAnzu PartnersBee PartnersConductor CapitalSJF VenturesThin Line Capital

Vorcat develops computational fluid dynamics (CFD) software based on a patented vortex method for simulating turbulent flows, aimed at reducing the need for physical testing such as wind tunnels.

Advanced ManufacturingAI & Machine LearningDeep Tech

Zymtronix develops cell-free, multi-enzyme biocatalysis systems to manufacture high-value industrial products without traditional fermentation.

AgTechBiotechNew Materials