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Calculus Capital Ltd.

Venture capital

London · Seed–Series A · 31 people tracked

Also known as Mcdonald Glencross Limited · Mcdonald-Glencross Limited

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Investment thesis

Calculus is a long-standing UK manager focused on tax-advantaged investing through EIS funds and VCTs, backing EIS and VCT qualifying companies since launching the first UK approved EIS fund in 1999. It runs a generalist EIS fund annually and multiple VCT share issues, and in 2022 launched a Knowledge Intensive EIS Fund. Its approach emphasises capital appreciation, a diligent investment and monitoring process, and a track record of profitable exits. In January 2026 it added the Calculus Inheritance Tax Solution, providing secured loans for film and TV productions.

Source: firm website, verified Aug 3, 2026.

Stage
Seed–Series A
Check
$2.5M
HQ
London, GB
Instruments
Equity
Founded
1999
Last 12 months
2 investments
Net assets · FY2025
$7.3M
Tracked investments
41
IPOs
3
Acquisitions
1

Team · 31 people

from the firm's website & curated & public directories
John Glencross· CEO and Co-Founderin
Bella White· Client Services
Christopher Gould· Financial Planning and Analysis Manager
Francesca Rayneau· Director, Head of Sales and Marketing
Frank Spurway· Assistant Director, Sales & Marketing
James Gower· Analyst, Sales and Marketing
Mariyah Dosani· Director - Media and Entertainment Financing
Matthew Moynes· Director, Sales & Marketing
Oliver Warren· Director, Sales & Marketing
Richard Banks· Associate Fund Administrationin
Natalie Evans· Finance Directorin

What they invest in

from 15 of 41 portfolio companies

Biotech ×9AI & Machine Learning ×7Deep Tech ×7Healthtech ×6Medical Devices ×5SaaS ×4Fintech ×2HR Tech ×2

HQs:United Kingdom×7United States×1

Who they back

founder profiles across 9 portfolio companies
33%
solo founders
3 of 9 mapped founding teams

Founding team size:solo founder×32 founders×33 founders×24+ founders×1

What their founders studiedfrom 10 founders with field-of-study data

Life Sciences ×3Chemistry ×2

Investments · 41 tracked

founders shown can be your intro path

By year:2026 · 12025 · 12024 · 12022 · 22021 · 12019 · 12018 · 22017 · 110 dated

Laverock Therapeutics Seedlaverocktx.comin✓ verified

Laverock Tx is a biotechnology company working in the gene therapy and gene editing space, with a leadership and advisory team drawn from cell and gene therapy, immunology, and life-science investing backgrounds.

BiotechDeep TechHealthtech

Co-investorsEos AdvisoryFuture Planet CapitalTekfen VenturesUK Innovation & Science Seed Fund

Arctic Shoresarcticshores.comin

Arctic Shores provides psychometric testing and recruitment tools designed to reduce hiring bias and support diversity goals for businesses.

AI & Machine LearningHR TechSaaS

Co-investorsBeringeaBeringea ProVen VCTPraetura Ventures

Arecorarecor.cominSep 2018

AreCor develops proprietary pharmaceutical products for diabetes, obesity, and cardiometabolic diseases using its Arestat technology platform.

BiotechDeep TechHealthtech

Sarah Howellin

Co-investorsAlbionVCCambridge Capital GroupSeneca Partners

Blu Wirelessbluwireless.comin𝕏May 2019 · $16.6M

Blu Wireless develops millimeter wave radio networking technology for wireless communications.

Deep TechDefense TechHardwareSemiconductorsBristol, GB

Anthony Murray(Chief Executive Officer)inJohnny Bray(Chief Financial Officer)inDave Purle(Chief Operating Officer)Ciara Barron(Director of Marketing)inDarren McNamara(Director of Technology Development)inJonathan Rogers(Director of Systems and Platforms)in

Co-investorsMaven Capital PartnersCambridge Angels groupPerscitus LLPSalica InvestmentsARMKendall Capital Partners+1 more

Blu Wireless Technologybluwirelesstechnology.comJun 2017

Bristol-based developer of mmWave wireless communication systems for defence, high-speed rail and other mobility markets.

Co-investorsGuinness VenturesPerscitus LLPARMCalculusWren Capital

Edifyin𝕏
Ensilitechensilitech.comin

EnsiliTech develops ensilication technology, a silica-based method to stabilise vaccines and biopharmaceuticals so they can be stored and transported without refrigeration.

BiotechCleantechDeep TechHealthtechMedical Devices

Asel Sartbaeva(Co-Founder & CEO)inMatt Slade(Co-Founder & Chief of Staff)inStephen Wells(Co-Founder & Advisor)Aswin Doekhie(Co-Founder & CTO)inSabine Ficek(CFO)inSimon Bennett(Chief Commercial Officer)

Co-investorsElbow Beach CapitalEos AdvisoryEmpirical VenturesHERmesa

Essentia Analyticsessentia-analytics.comin𝕏

Essentia Analytics provides behavioral analytics software and performance consulting for professional investors, helping fund managers reduce bias, maintain investment discipline and improve returns.

AI & Machine LearningFintechSaaS

Clare Flynn Levy(CEO)in

Co-investorsSalica Investments

Inviziusinvizius.cominMay 2021

Invizius develops therapeutics targeting the complement system to treat kidney disease and other disorders driven by uncontrolled immune activation.

BiotechDeep TechHealthtechMedical DevicesGlasgow, GB

Dr Magnus Nicolsonin

Co-investorsCalculusMercia VenturesOld College CapitalScottish EnterpriseScottish Investment BankSyensqo Ventures

Maven Screen Mediamavenscreenmedia.com

Maven Screen Media is an independent production company that develops and produces multi-platform film and television content with a focus on increasing representation for women in front of and behind the camera.

Creator EconomyMedia & Entertainment

Celine RattrayTrudie Stylerin

Co-investorsAdeline

Optalitixoptalitix.comin

Optalitix provides an enterprise platform that consolidates pricing and underwriting workflows, enabling organizations to modernize their pricing models without disruption through incremental cloud migration and governance.

AI & Machine LearningCloud ComputingEnterprise SoftwareFintechInsurTechSaaSLondon, GB

Co-investors24 Haymarket

Oxford BioTherapeuticsoxfordbiotherapeutics.com

Oxford BioTherapeutics is a clinical-stage oncology company developing antibody-based therapies for cancer treatment.

BiotechHealthtechMedical DevicesOxford, GB

Co-investorsOxfordPercipient CapitalPerscitus LLP

Resurrect Bioresurrect.bioinFeb 2026 · $8.1M

Resurrect Bio develops genetic disease-resistance traits for crops by restoring plant R-genes, using its FloraFold AI platform and rapid in-planta screening for trait discovery.

AgTechAI & Machine LearningBiotechLondon, GB

Cian Duggan(CEO & Co-Founder)inTolga Bozkurt(Co-Founder)inSophien Kamoun(Co-Founder)in

Co-investorsFuture Planet CapitalSynBioVenUK Innovation & Science Seed FundAgFunderPymwymic

Rotageekrotageek.comin𝕏Jun 2022

Rotageek provides workforce management and scheduling software for rota planning, including demand forecasting, labour modelling, auto-scheduling, time and attendance tracking, and leave management.

AI & Machine LearningFuture of WorkHR TechRetail TechSaaS

Chris McCullough(Co-founder)inRoy Pounder(Co-founder)inNick Mann(Co-founder)in

Co-investorsVenture FoundersVolution VenturesCalculusGresham HouseGresham House VenturesMobeus Equity Partners+1 more

Smartr365smartr365.comin

An end-to-end mortgage and protection platform that automates the mortgage process and integrates brokers, estate agents, homebuyers and lenders.

Conor Murphy(Founder)in

Co-investorsPembroke VCTFig VCLegal & General

Spectral MDspectralmd.comSep 2018

AI medical diagnostics company whose DeepView imaging platform predicts whether burns and other wounds will heal.

BiotechDallas, US

J. Michael DiMaio(Executive Officer, Director)John H, Stevens(Director)Erich Spangenberg(Director)

Tagomicstagomics.comFeb 2024

Tagomics develops multimodal technologies for precision medicine and next-generation diagnostics.

AI & Machine LearningBiotechDeep TechMedical DevicesCambridge, GB

Dr Jack Kennefick(Co-founder, Director & Chief Executive Officer)Dr Robert Neely(Co-founder, Director & Chief Scientific Officer)

Co-investorsIllumina VenturesIQ CapitalCalculusInnovate UKMEIF Proof-of-Concept & Early Stage FundMercia Ventures+2 more

Trogenixtrogenixbio.cominOct 2025

Trogenix develops precision gene therapies for cancer using its Odysseus platform and Synthetic Super-Enhancer (SSE) technology, engineered DNA elements activated only in diseased cell states to selectively target and kill tumour cells while activating the immune system.

AI & Machine LearningBiotechDeep TechHealthtechMedical Devices

Co-investorsACADEMY INVESTORAIN VenturesIQ CapitalLongeVCOld College Capital4BIO Capital

Wazokuwazoku.comin𝕏Sep 2022

Wazoku is a London-based innovation management company combining an AI platform with the Innocentive open-innovation solver marketplace.

Simon Hill(Founder)inRosemarie Diegnan(Founder)in

Co-investorsCambridge Angels groupOctopus VenturesSaaS Capital

Weedingtechweedingtech.com

Supplies machines and supplies that kill weeds without using herbicides.

Co-investorsBoundary CapitalCalculus

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Axol Bioscience Censo BiotechnologiesBooked ItBrouhaha EntertainmentC4X DiscoveryEconsultFiscal TechnologiesGratefulHinterviewHome Team ContentIpvLaverock TherapeuticsMip DiagnosticsMoNotifyOpen Energy MarketQuaiRaindog FilmsRiff RaffScancellWonderhoodWorkl

Portfolio news

latest coverage across their companies

Principals & officers · per Companies House

what is this? ⓘ
Arthur John Glencross

Director · British · since 1999

Susan Rebecca Mcdonald

Director · American · since 1999

Julie Hong Nhan Ngo

Director · British · since 2022

Ownership & control

Calculus Holdings Limited — 75–100% of shares, 75–100% of voting rights, right to appoint and remove directors

Frequently asked questions

How many investments has Calculus Capital Ltd. made?
Calculus Capital Ltd. has 41 tracked investments, 4 of which have exited, including 2 dated in the last 24 months.
What stage does Calculus Capital Ltd. invest at?
Calculus Capital Ltd. invests at the Seed, Series A stages.
What is Calculus Capital Ltd.'s typical check size?
Calculus Capital Ltd. typically writes checks of $2.5M.
What sectors does Calculus Capital Ltd. focus on?
Calculus Capital Ltd. focuses on Biotech, Data & Infrastructure, Enterprise Software, Fintech, Healthtech, IoT, Media & Entertainment, Medical Devices, SaaS, Sector Agnostic.
Where is Calculus Capital Ltd. located?
Calculus Capital Ltd. is headquartered in London, GB.
Does Calculus Capital Ltd. lead rounds?
Calculus Capital Ltd. has led 4 of the 10 rounds where its role is on record.
Who does Calculus Capital Ltd. co-invest with?
Calculus Capital Ltd. most often shares deals with IQ Capital, Perscitus LLP, Boundary Capital, among 32 tracked co-investors.

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