HEALTHCARE ROYALTY PARTNERS — Full Portfolio

Agenus is a biotechnology company developing cancer immunotherapies, including its lead investigational combination of botensilimab (an anti-CTLA-4 antibody) and balstilimab (a PD-1 inhibitor), known as BOT+BAL.

BiotechHealthtechLexington, US

Garo Armen(Chairman & CEO, Co-founder)Ozer Baysal(Executive Officer)RSRobert Stein(Executive Officer)Christine Klaskin(Executive Officer)inKaren Valentine(Executive Officer)SOSteven O'Day(Chief Medical Officer)in

Co-investorsADAdvent Life SciencesGRGrazia Equity GmbHOBOberland CapitalCOCommodore CapitalINInvusLILigand Pharmaceuticals+1 more

Apnimed develops investigational oral pharmaceutical therapies for obstructive sleep apnea (OSA), including its lead clinical candidate AD109, a neuromuscular approach intended to treat undertreated and untreated OSA patients.

BiotechDigital HealthHealthtechCambridge, US

LGLawrence G. Miller(Executive Officer, Director)inDMDennis Molnar(Executive Officer)inBWBarry Wohl(Chief Business Officer)inKMKetan Mehta(Head of Product and Engineering, Connected Wearables)Ron Farquhar(Director)Gerald Chan(Director)

Co-investorsALAlpha Wave GlobalMOMorningside GroupSESectoral Asset Management

Aptevo Therapeutics is a clinical-stage biotechnology company developing bispecific and trispecific immunotherapies to treat cancer.

BiotechHealthtechSeattle, US

MLMarvin L. White(Executive Officer, Director)inDTDaphne Taylor(Executive Officer)Jeffrey G. Lamothe(Executive Vice President and Chief Operating Officer)

BoardJohn E Niederhuber(Director)Daniel J Abdun-Nabi(Director)Grady Grant III(Director)

Co-investorsYOYorkville Advisors

Atara Biotherapeutics develops allogeneic T-cell immunotherapies using its proprietary EBV T-cell platform to harness the immune system for treating disease.

BiotechHealthtechMedical DevicesThousand Oaks, US

AnhCo Nguyen(President and Chief Executive Officer)Isaac Ciechanover(Founder)

Co-investorsDADag VenturesECEcoR1 CapitalKLKleiner PerkinsDODomain AssociatesFIFidelity Investments

Coherus Oncology develops and commercializes immuno-oncology therapies, including the approved LOQTORZI, to treat patients with cancer.

BiotechHealthtechMedical DevicesRedwood City, US

DMDennis M. Lanfear(Executive Officer, Director)DLDenny Lanfear(Founder)inAlan C. Herman(Executive Officer)inJean-Frederic Viret, Ph.D.(Executive Officer)Peter K. Watler, Ph.D.(Executive Officer)Barbara K Finck, M.D.(Executive Officer)

Co-investorsF-F-Prime CapitalSOSofinnova VenturesVEVenrock

Nektar develops therapies that modulate the immune system to treat autoimmune diseases and inflammatory conditions, targeting the root causes of immune dysfunction.

BiotechHealthtechSan Francisco, US

HWHoward W. Robin(Executive Officer, Director)GMGil M. Labrucherie(Executive Officer)inManinder Hora(Executive Officer)inStephen K. Doberstein(Executive Officer)John Nicholson(Executive Officer)JBJillian B. Thomsen(Executive Officer)

Co-investorsNENew Enterprise Associates (NEA)

BiotechTel Aviv

Shmuel Cabilly(Director)June Almenoff(Executive Officer)Ofer Tsimchi(Director)Rick D Scruggs(Executive Officer, Director)Nicolas Weinstein(Director)Alla Felder(Director)

Co-investorsLILifeSci Venture Partners

Spero Therapeutics is a clinical-stage biopharmaceutical company developing medicines for immune-mediated diseases, led by SP001, a third-generation anti-CD40L antibody targeting IgG4-related disease.

BiotechCambridge, US

AMAnkit Mahadevia(Executive Officer, Director)inSGStephen Garbacz(Executive Officer)inEsther Rajavelu(Director, President, Chief Executive Officer, Chief Financial Officer, Chief Business Officer and Treasurer)in

BoardJFJean-Francois Formela(Director)inReza Halse(Director)Casper Breum(Director)

Co-investorsGVGV (Google Ventures)MRMRL Ventures FundOUOUP (Osage University Partners)RARA CapitalALAlphabetATAtlas Venture+1 more

BiotechIrvine, US

Alan Waterhouse(President and Chief Operating Officer)Jason Tester(Chief Financial Officer and Secretary)James V. Mazzo(President, Chief Executive Officer and Chairman of the Board)

BoardArjun Arora(Director)Richard L. Lindstrom, M.D.(Director)William J. Link(Director)

Co-investorsEVEvidity Health CapitalFLFlying L PartnersRERevelation PartnersSVSV Life SciencesVEVersant Venture AIV HoldingsVEVersant Ventures

The site presents ADYNOVATE, a PEGylated recombinant antihemophilic Factor VIII injectable used to treat and control bleeding in adults and children with hemophilia A.

BiotechHealthtech

A biopharmaceutical company (Ipsen, following its acquisition of Albireo Pharma) developing and commercializing medicines in oncology, rare diseases, and neuroscience for patients with high unmet medical needs.

BiotechHealthtech

Co-investorsDEDecheng Capital

Ardelyx is a biopharmaceutical company that develops first-in-class medicines for patients with unmet medical needs.

BiotechFremont, US

Mark Kaufmann(Executive Officer)EGElizabeth Grammer(Executive Officer)inDRDavid Rosenbaum(Executive Officer)inJeremy Caldwell(Executive Officer)MRMike Raab(Executive Officer, Director)in

BoardDavid Mott(Director)

Co-investorsFOForesite CapitalNENew Enterprise Associates (NEA)

BridgeBio develops treatments for genetic conditions and cancers using a decentralized hub-and-spoke model, where autonomous teams focus on specific diseases or drug candidates while a central hub provides clinical, regulatory, and commercial support.

BiotechHealthtech

Neil Kumar(Founder)

Co-investorsAIAisling CapitalAMAmzak HealthECEcoR1 CapitalFRFrazier Life SciencesLOLongwood FundSESequoia Capital+2 more

BiotechNewton Centre, US

Chaime Orlev(Executive Officer)Roni Mamluk(Executive Officer, Director)

BoardScott Minick(Director)inTTTodd T. Foley(Director)inVincent Miles(Director)AKAnsbert K. Gadicke(Director)in

Co-investorsSOSofinnova VenturesABAbingworthARARCH Venture PartnersMPMPM BioImpact

Clearside Biomedical is an intellectual property holding, investment, and commercialization company focused on its suprachoroidal space (SCS) ocular drug-delivery platform and microinjector technology.

BiotechHealthtechMedical DevicesAlpharetta, US

Mark Prausnitz(Director)inCharles Deignan(Executive Officer)GNGlenn Noronha(Executive Officer)inDHDaniel H. White(Executive Officer, Director)in

BoardEvgeny Zaytsev(Director)DYDerek Yoon(Director)in

Co-investorsMOMountain Group CapitalSOSolasta VenturesHAHatterasHAHatteras Venture Partners

Curis is a biopharmaceutical company focused on drug development and clinical advancement.

BiotechHealthtech

James Dentzer(Chief Executive Officer)

EBVALLO is an on-demand allogeneic T-cell immunotherapy for treating relapsed or refractory EBV-positive post-transplant lymphoproliferative disease.

BiotechDigital HealthMedical Devices

ELIGARD is a GnRH agonist medication in injectable form used to treat prostate cancer by reducing testosterone production.

BiotechHealthtechMedical Devices

Sophisticated optics for illumination and enhanced visualization in surgical procedures.

HealthtechSan Francisco, US

Kenneth Trauner(Executive Officer, Director)Alex Vayser(Executive Officer)Philip Sawyer(Executive Officer, Director)inTheresa Brandner-Allen(Executive Officer)Brett Robertson(Executive Officer)Doug Rimer(Executive Officer)

Co-investorsALAlpine MeridianWIWindham Capital PartnersAVAvedro, Inc.KLKleiner PerkinsVAValence Advantage Life SciencesWEWellington Management

IQIRVO is a prescription medicine for treating primary biliary cholangitis (PBC) in adults, used either in combination with ursodeoxycholic acid or as a standalone treatment for patients unable to tolerate standard therapy.

BiotechHealthtechMedical Devices

Karyopharm is a pharmaceutical company developing drugs based on its SINE (Selective Inhibitor of Nuclear Export) technology, with medicines targeting cancers including multiple myeloma and diffuse large B-cell lymphoma.

BiotechHealthtechNewton, US

SPStuart Poulton(Executive Officer)inMichael Mano(Executive Officer)inRRReshma Rangwala(Executive Officer)inRPRichard Paulson(CEO)inStephen Mitchener(Executive Officer)inMichael Mason(Executive Officer)in

Co-investorsAVAvoro Capital AdvisorsFOForesite CapitalRARA Capital

KORSUVA is a prescription medicine that treats moderate-to-severe itching associated with chronic kidney disease in adults undergoing hemodialysis.

BiotechDigital HealthHealthtechMedical Devices

Lantheus is a radiopharmaceutical company that develops, manufactures, and commercializes radiodiagnostics and radiotherapeutics for cancer detection, treatment and monitoring, as well as precision diagnostics for non-oncologic diseases.

BiotechHealthtechMedical DevicesNorth Billerica, US

Lyrica is a pharmaceutical product used to manage fibromyalgia, a chronic condition characterized by widespread pain and fatigue.

BiotechHealthtechMedical Devices

Nanobiotix develops physics-based nanotherapeutics for cancer treatment, applying nanotechnology to expand therapeutic options for oncology patients.

BiotechDeep TechMedical Devices

Co-investorsKAKaristaSESeventure PartnersJEJefferies

OPKO Health is a fully integrated healthcare company developing multispecific therapies for serious diseases including cancers and infectious diseases, and operates BioReference Laboratories, a clinical reference laboratory serving approximately 11 million patients annually in the U.S.

BiotechDigital HealthHealthtechMedical DevicesMiami, US

GNGary Nabelin

Orenitram is a prescription oral medication containing treprostinil, indicated to treat pulmonary arterial hypertension (PAH) by slowing disease progression and improving exercise capacity in adults.

BiotechHealthtech

REGENXBIO is a gene therapy company developing treatments for rare and retinal diseases using its NAV Technology Platform of viral vectors, which it also licenses to other pharmaceutical and biotech companies.

BiotechHealthtechRockville, US

Kenneth T. Mills(Executive Officer, Director)

BoardJohn Daniel Kiser(Director)Allan M. Fox(Director)Benjamin Auspitz(Director)Donald J. Hayden, Jr.(Director)

Co-investorsF-F-Prime CapitalFOFoothill VenturesVEVenrock

RELISTOR is a prescription medication containing methylnaltrexone bromide that treats opioid-induced constipation in adults with chronic pain or advanced illness.

BiotechDigital HealthHealthtechMedical Devices

Rhythm Therapeutics develops precision medicines for rare neuroendocrine diseases, particularly those affecting the melanocortin-4 receptor pathway.

BiotechDigital HealthHealthtechMedical DevicesBoston, US

Keith Gottesdiener(Executive Officer, Director)inBHBart Henderson(Mr. Henderson is the President and Treasurer of the Issuer.)inDMDavid Meeker(President and Chief Executive Officer)in

BoardETEdward T. Mathers(Director)inJSJonathan Silverstein(Director)inNENeil Exter(Director)in

Co-investorsFOForesite CapitalNENew Enterprise Associates (NEA)PFPfizer Venture InvestmentsWEWellington ManagementOROrbiMedTHThird Rock Ventures

SEYSARA is a prescription medication with a patient co-pay assistance program (Almirall Advantage) that offers savings on retail and network pharmacy purchases.

BiotechHealthtech

Spero Therapeutics is a clinical-stage biopharmaceutical company developing next-generation immunology and inflammation medicines, particularly targeting patients with serious diseases and major treatment gaps.

BiotechHealthtechCambridge, US

Co-investorsATAtlas VentureTHThe Kraft Group

A company offering regenerative and aesthetic medical products for facial, breast, and body treatments across all stages of life.

HealthtechMedical DevicesSan Diego, US

Nicholas L. Teti, Jr.(Executive Officer, Director)Joseph A. Newcomb(Executive Officer)Stewart M. Brown(Executive Officer)in

BoardClarke B. Futch(Director)Paul J. Hadden(Director)Todd C. Davis(Director)

Co-investorsBIBioBritESEssex Woodlands Healthcare PartnersPOPolaris Partners

IBSRELA is a prescription medication containing tenapanor designed to treat irritable bowel syndrome with constipation (IBS-C) in adults by reducing constipation and abdominal pain.

BiotechHealthtechMedical Devices

TG Therapeutics is a biopharmaceutical company focused on developing treatments for cancer patients.

BiotechHealthtechMedical Devices

Michael S. Weiss(CEO)

Theravance Biopharma develops FDA-approved pharmaceutical treatments, including YUPELRI for chronic obstructive pulmonary disease (COPD) maintenance treatment.

BiotechHealthtechMedical Devices

RERick E Winningham(Chief Executive Officer)inRFRhonda F. Farnum(Senior Vice President, Commercial and Medical Affairs and Chief Business Officer)inBrett A. Grimaud(Senior Vice President, General Counsel and Secretary)inSKStuart Knight(Senior Vice President, IT&I and Chief Information Officer)AMAine Miller(Senior Vice President, Development and Head of Ireland Office)Stacy Pryce(Senior Vice President and Chief Strategy Officer)in

TRELEGY is a once-daily prescription inhaler used long-term to treat COPD (including chronic bronchitis and emphysema) and asthma in adults.

Biotech

uniQure is a biotech company developing gene therapies for serious genetic diseases.

BiotechHealthtechMedical Devices

MKMatthew Kapustain

Co-investorsADAdvent Life SciencesALALS Investment FundFOForesite CapitalRIRidgeback CapitalFOForbion

Vafseo (vadadustat) is a once-daily oral prescription medicine that treats anemia caused by chronic kidney disease in adults who have been on dialysis for at least three months.

BiotechHealthtech

XOMA Royalty is a biotech royalty aggregator that acquires the economic rights to future milestone and royalty payments tied to partnered pre-commercial clinical candidates, providing sellers with non-dilutive, non-recourse funding.

BiotechFintech

OHOwen Hughes(Chief Executive Officer)inJTJeffrey Trigilio(Chief Financial Officer)inBSBrad Sitko(Chief Investment Officer)inMaricel Montano(Chief Legal Officer)

Co-investorsLILigand PharmaceuticalsSASanderling Ventures

Zevra Therapeutics develops and commercializes rare disease treatments, including therapies for Niemann-Pick disease type C and urea cycle disorders.

BiotechHealthtechMedical Devices

NMNeil McFarlanein

ZOLGENSMA is a gene replacement therapy that delivers a working SMN gene to treat spinal muscular atrophy (SMA), a rare genetic disease affecting motor nerve cells.

BiotechDigital HealthHealthtechMedical Devices