National Institutes of Health (NIH) — 2016 Investments

Oncovir is a biotech company developing Hiltonol, an experimental viral mimic that activates innate and adaptive immunity for solid cancer and infectious disease treatment.

BiotechHealthtech

HealthtechMadison, US

Carl Gulbrandsen(Director)Benjamin Titz(Executive Officer, Director)Kevin W. Eliceiri(Director)Thomas R. Mackie(Executive Officer, Director)Adam J. Uselmann(Executive Officer, Director)Andreas Velten(Director)

Two Pore Guys is a diagnostics company developing a handheld nanopore-based analyte sensor for point-of-care testing, with applications including liquid biopsy cancer detection.

BiotechDeep TechDigital HealthHardwareMedical DevicesSanta Cruz, US

Co-investorsKHKhosla VenturesDEDEFTA Partners

A care coordination platform that connects patients' behavioral and physical health data across providers, health plans, and government agencies, delivering real-time alerts, controlled substance data, and analytics inside clinical workflows.

AI & Machine LearningDigital HealthHealthtech

Opticent Health develops Aurora X4, a free-standing OCT imaging platform for clinical research of the human eye that combines hardware and software with advanced features like pupil monitoring and NIR scanning laser ophthalmoscopy for patient alignment and imaging.

AI & Machine LearningBiotechHealthtechMedical Devices

Influents Innovations (Or-Bis) develops evidence-based programs and digital products that apply behavioral research and technology to challenges in health care, social services, and education, addressing areas such as perinatal depression, early literacy, oral health, and youth tobacco prevention.

Digital HealthEdTechHealthtech

Organix provides custom synthesis, drug delivery, polymer chemistry, and analytical services for biotech, pharmaceutical, and materials science companies.

BiotechDeep TechEnterprise SoftwareNew MaterialsWoburn, US

Anu Mahadevan(CEO)Paul Blundell(President)

Oricula Therapeutics develops small-molecule therapeutics for hearing loss and ototoxicity prevention, with a focus on aminoglycoside antibiotic-induced hearing damage.

BiotechHealthtechMedical DevicesSeattle, US

Edwin W. Rubel, PhD(University of Washington, Chaired Professor)David W. Raible, PhD(University of Washington, Professor)Julian Simon, PhD(Affiliate Associate Professor, University of Washington)

Origent develops predictive analytics and AI platforms for drug development and patient empowerment, helping pharmaceutical sponsors reduce clinical trial risk through patient-level forecasting and narrative health data capture.

AI & Machine LearningBiotechDigital HealthHealthtechMedical Devices

OtoNexus Medical Technologies is developing an ultrasound-based otoscope (Novoscope) that uses a miniaturized sensor in a single-use ear speculum tip to give clinicians objective, point-of-care data on middle-ear fluid and infection type.

AI & Machine LearningDigital HealthHardwareHealthtechMedical DevicesSeattle, US

CCCaitlin Cameron(Chair & CEO)in

Co-investorsGOGolden SeedsCACatalytic Impact FoundationDEDellin InvestmentsFAFarvatn VentureKEKeiretsu ForumMIMindshift Capital+6 more

Paradromics develops a brain-computer interface (BCI) system, with FDA Breakthrough Device Designations for speech decoding and digital device control, and works with academic medical institutions on translational BCI research.

BiotechDeep TechHealthtechMedical DevicesAustin, US

Matt Angle(Founder and CEO)inRon Kelly(Director)Thomas Krummel(Director)Adam Kablanian(Director)

Co-investors1515th RockALAlpha EdisonANAnthropy PartnersATATEL VenturesCACapital FactoryCLCloudStone Capital+28 more

PetxLLC develops advanced PET/CT imaging systems and high-resolution medical imaging equipment for clinical and preclinical applications.

Deep TechHardwareHealthtechMedical DevicesSeattle, US

Paul E. Kinahan(co-Founder, VP of Research)Lawrence R. Macdonald(co-Founder)William Hunter(CEO, CSO)

BiotechChestnut Hill, US

JIJoseph Italiano(Director)inJonathan Thon(Director)Sven Erik Karlsson(Executive Officer)Peter Finn(Executive Officer)

Co-investorsBOBoston Harbor AngelsQIQiming HealthcareTHThird Rock VenturesVIVivo Capital

Madison, US

Barbara A. Israel(Director, Promoter)Tom Crabb(Director)Christopher Murphy(Director, Promoter)Nicholas L. Abbot(Director, Promoter)Timothy G. Burland(Executive Officer)Walter E. Dewey(Director)

BiotechWoburn, US

Ian Magazine(Executive Officer)James Coull(Executive Officer, Director)Bruce Armitage(Executive Officer, Director)

BoardJoseph Walton(Director)

Potomac Affinity Proteins develops protein-based engineered products and technologies derived from NIH-funded research for biomedical and diagnostic applications.

BiotechDeep TechMedical DevicesCollege Park, US

Philip N. Bryan(Founder and Scientific Director)

Precision Vision sells the Tono-Pen AVIA, a handheld tonometer device for measuring intraocular pressure in ophthalmic settings.

HardwareHealthtechMedical DevicesWoodstock, US

Progenitec develops non-contact, disposable diagnostic devices that test wound dressings to identify clinical conditions such as chronic wounds and infections, guiding treatment decisions.

AI & Machine LearningBiotechDigital HealthHealthtechMedical Devices

Promiliad Biopharma is a drug discovery company focused on developing novel antibiotics through natural product research and synthetic combinatorial approaches.

BiotechDeep TechHealthtech

Proportional Technologies develops neutron detection systems using boron-coated straw (BCS) technology as a replacement for expensive helium-3 detectors, serving security, nuclear weapons detection, and scientific research applications.

Deep TechDefense TechHardwareAngleton, US

Jeffrey L. Lacy(Founder, Ph.D.)

BiotechSyracuse, US

RURichard Uhlig(Executive Officer, Director)Erica Ash(Executive Officer)James Croke(Executive Officer, Director)Richard Bongo(Executive Officer, Director)inNicholas Gianadda(Executive Officer)BGBryan Greene(Executive Officer)in

QUASAR develops dry biosensing hardware and software for monitoring cognitive and physiological states without gels or adhesive pads.

AI & Machine LearningHardwareHealthtechMedical DevicesUSA, US

Recomb Tech develops beta-amyloid capturing therapeutic molecules, with a flagship candidate called AmyTrap-3, to treat Alzheimer's and other beta-amyloidopathy diseases.

BiotechDeep TechLongevity

Resodyn Corporation is a research and development company that engineers and manufactures technology products and provides engineering and manufacturing services, developing solutions through public grants (such as SBIR) and private R&D contracts.

Advanced ManufacturingDeep TechHardware

HealthtechSan Francisco, US

Reza Naima(Executive Officer, Director)

Co-investorsEMEmergent Medical Partners, LLPKEKeshif VenturesLALaunchCapitalLALaunch CapitalNONorwich Ventures

BiotechNew York, US

MTMasoud Tavazoie(Chief Scientific Officer)DDDavid Darst(Chief Operating Officer)IKIsabel Kurth(Vice President - Research)

BoardShahram Seyedin-Noor(Executive Chairman)Nancy Chang(Director)

Co-investors+N+ND CapitalOCOceanpine CapitalSOSofinnova Partners

BiotechBoston, US

William Adams(Executive Officer, Director)Michael Serrano-Wu(Director)

Rubitection develops the Rubitect Assessment System for early detection and management of pressure injuries (bedsores) in healthcare settings.

AI & Machine LearningHealthtechMedical DevicesRochester, US

SGSanna Gaspard(CEO)

BoardJGJosh Ghaims(Technology Advisor)in

Co-investorsD3D3VCTETechstars

Salus Discovery develops molecular diagnostics technologies, including passive sample pre-concentration (Flow) that boosts lateral-flow assay sensitivity and rapid analyte extraction, concentration, and purification methods (ESP) for sample preparation.

BiotechDeep TechMedical DevicesMadison, US

Sano Chemicals is a clinical-stage drug development company creating new chemical entities (NCEs) as first-in-class treatments for antimicrobial-resistant fungi and bacteria, with additional research into cancer applications.

BiotechHealthtechLongevityMedical DevicesBryan, US

James Leif Smith(Executive Officer)

Secretory IgA, Inc. develops orally available antibody therapeutics to treat intestinal diseases, including Clostridioides difficile-associated disease and COVID-19 prevention.

BiotechDigital HealthHealthtechMedical DevicesAnn Arbor, US

Sedia manufactures laboratory-based assays for detecting recent HIV-1 infections, enabling public health monitoring and outbreak surveillance in high-risk regions.

BiotechDigital HealthHealthtechMedical DevicesBeaverton, US

Roger Gale(Founder)Ronald Mink(Founder)

BiotechCharlestown, US

ESEric Stern(Executive Officer, Director, Promoter)AVAleksandar Vacic(Executive Officer, Promoter)inJames Parker Cassidy(Director)Scott Yaphe(Director)Steven E. Lufkin(Executive Officer, Director)Michael Rubin(Director)

Co-investorsRARA CapitalSASands Capital Ventures

BiotechGoleta, US

Patrick Daugherty(Executive Officer, Director)Kristin Loomis(Director)Bill Welch(Director)inNNNick Naclerio(Director)inJohn Shon(Executive Officer)

Co-investorsILIllumina InnovationILIllumina Ventures

SGC Pharma, under the brand GummiMED, develops pharmaceutical medications delivered in a gummy format as an alternative to traditional pills, tablets, and syrups.

BiotechHealthtech

SILCS is computational chemistry software that maps functional group affinities across protein surfaces to guide drug design.

AI & Machine LearningBiotechDeep Tech

Kelsey Abernathy(Chief Executive Officer)Olgun Guvench(Managing Partner)Alexander MacKerell(Chief Science Officer)

Simphotek Medical Devices develops light-based cancer treatment planning software using photodynamic therapy dosimetry to guide physicians in administering personalized light and drug therapies.

Deep TechHealthtechMedical DevicesBuffalo, US

Gene Parilov(Co-founder and CTO)Mary Potasek(Co-founder and CSO)Karl Beeson(Co-founder and VP of Technology)

SiMPore develops silicon nanomembrane technology products for biomedical research, environmental analysis, and materials science applications.

BiotechDeep TechHardwareNew MaterialsRochester, US

James Roussie(Chief Scientific Officer & Co-Founder)James McGrath(Corporate Director & Co-founder)Thomas Gaborski(Corporate Director & Co-founder)

QuartzBio provides a conversational AI platform that enables clinical-stage biopharma teams to gain real-time insights from fragmented sample, clinical, and biomarker data across their entire lifecycle.

AI & Machine LearningBiotechData & InfrastructureDigital HealthHealthtech

Co-investorsNANat Turner

SonoMotion develops ultrasound-based medical devices for treating kidney stones, working with urologists and clinical partners.

Deep TechHealthtechMedical DevicesSan Mateo, US

OLOren Levy(Chief Executive Officer, Co-Founder)inPaul Douglas Corl(Executive Officer)Doug Corl(Chief Technology Officer)Michael Bailey(Executive Officer, Director)Barbrina Dunmire(Director)

Co-investorsBIBioventures Investors

Soterix Medical manufactures PainX TENS devices for drug-free pain relief through transcutaneous electrical nerve stimulation.

BiotechDeep TechDigital HealthHealthtechMedical DevicesTri-state area, US

Co-investorsELElevate Ventures

Spectral Energies develops advanced laser and propulsion technologies for the aerospace, defense, transportation, and energy sectors, drawing on extensive research and government contracts with agencies including DoD, NASA, and DoE.

Deep TechDefense TechEnergyHardwareBeavercreek, US

Sukesh Roy(CEO)Sivaram P. Gogineni(President)Mitch Icard(COO)

HealthtechLafayette, US

Brian Kopp(Executive Officer, Promoter)inSMSteve Mogensen(Executive Officer, Director, Promoter)in

Co-investorsELElevate Ventures

Speragen is a biotech company founded to address the challenges faced by patients with rare genetic disorders, specifically SSADH deficiency, by accelerating the development and availability of therapies.

Biotech

A mother of two children affected with SSADH deficiency

Spheryx develops Total Holographic Characterization technology for analyzing suspensions at the sub-visible particle level, including detecting protein aggregates and particles in biopharmaceuticals.

BiotechDeep TechHardwareNew York, US

LPLaura Philips(Executive Officer, Director)inDavid Grier(Director)

BiotechSan Clemente, US

Derek Herrera(Executive Officer, Director)Christopher Jennings(Director)Bill Colone(Executive Officer, Director)Kenneth Baker(Director)

Co-investorsPAParticular VenturesSTStorm Industries InvestmentsSVSv Tech Ventures, Inc.

STARGATES is an engineering and technology company providing systems integration, cybersecurity, and software development services to federal and defense agencies as well as Fortune 500 companies.

CybersecurityDeep TechDefense TechEnterprise SoftwareArlington, US

Starship Health develops software frameworks and tools for behavioral public health, including local social-network smartphone apps, virtual role-playing tutors for communication skills training, and analytical tools for mapping and diagnosing care coordination cases.

AI & Machine LearningDigital HealthEdTechHealthtech

StemMed provides patient-derived xenograft (PDX) models and related research materials for cancer research, serving biomedical researchers conducting studies at their own facilities.

BiotechDeep TechDigital HealthHealthtechMedical DevicesHouston, US

Dr. Tweardy(Head of the Division of Internal Medicine, Professor of Infectious Diseases and Molecular & Cellular Oncology)Michael Lewis(Associate Professor in the Departments of Molecular and Cellular Biology and Radiology)

Tempest provides mathematical and statistical modeling, optimization, and data management services to clients across health, life sciences, engineering, and logistics sectors.

Data & InfrastructureDeep TechEnterprise SoftwareGovTech

Sunnylife Pharma develops pharmaceuticals to address unmet medical needs in disease treatment, founded by former Merck scientists and collaborating with industry and academic partners globally.

BiotechHealthtechMedical DevicesNorth Brunswick, US

Veteran Merck scientists (group)

Swallow Solutions develops products for people with dysphagia (difficulty swallowing), offering specially formulated beverages and desserts to meet hydration and nutrition needs and reduce choking risk, as well as medical devices for oropharyngeal strengthening therapy.

FoodTechHealthtechMedical DevicesMadison, US

JRJoAnne Robbins, Ph.D.(Director)Robert A. Carlson, M.D.(Executive Officer)EHEric H. Horler(Executive Officer, Director)Raymond Heller(Executive Officer)

BoardThomas G. Schuster(Director)Terence F. Kelly(Director)

Sylvatica Bio develops organ and tissue preservation technologies, including supercooling methods that extend the viability of human organs such as livers outside the body.

BiotechDeep TechMedical Devices

SESebastian Eriksson Giwa, PhD(Founder)inMike Taylor(Founder)in

Co-investorsSTStartXTATaihill Venture

Symbios Technologies develops an energy-efficient aqueous plasma technology platform for water and wastewater treatment and recycling.

CleantechClimate TechDeep Tech

Synvivia engineers molecules designed to reprogram cells.

AI & Machine LearningBiotechHealthtechSan Francisco, US

GLGabriel Lopez(CEO)in

Co-investorsCACAL InnovationCACalifornia Innovation FundCRCreative VenturesGAGaingelsMEMetaplanetTHThundermark Capital+5 more

System Biosciences develops tools for studying gene and protein function in complex biological systems, leveraging lentiviral vectors and reporter technologies.

BiotechDeep TechHealthtechMedical DevicesPalo Alto, US

Shasqi is a biotech company developing pre-targeted cancer therapeutics using click chemistry to direct cancer drugs to tumors, aiming to improve efficacy while reducing dose-limiting toxicities.

BiotechHealthtechSan Francisco, US

José M. Mejía Oneto(CEO & Founder)

BiotechBranford, US

John Richard Nobile(Executive Officer, Director, Promoter)John Davidson(Executive Officer, Director, Promoter)

Co-investorsFRFreemind InvestmentsCOConnecticut InnovationsLELeading Edge Ventures

Reading Plus is an adaptive literacy instruction platform for schools that improves reading comprehension, fluency, and motivation through assessment-driven instruction grounded in decades of reading research.

EdTechSaaS

Earl TaylorJames TaylorCarl TaylorStanford TaylorMark Taylor

Tempo Therapeutics is a biotechnology company developing therapeutics, with a focus that includes dermatology.

BiotechHealthtechMedical DevicesSan Diego, US

WWWestbrook Weaver(Founder & CEO)inDGDonald Griffin(Founder & CSO)SDStephanie Deshayes(VP R&D)Kwame Ulmer(Chief Regulatory Officer)PSPhilip Scumpia(VP of Medical Affairs, Dermatology)inEREric Richman(Executive Officer, Director)in

Co-investorsSUSugati Ventures

DNA Medicine Institute is a med-tech incubator and biomedical technology innovator that develops diagnostic systems, including its flagship rHEALTH platform, which compresses multiple lab assays into handheld devices validated in clinical, space, and austere environments.

BiotechDeep TechMedical DevicesSpace Tech

Eugene Y. Chan(President and Chief Scientist)

Third Pole develops portable and miniaturized devices that generate inhaled nitric oxide on-demand for hospital and mobile treatment of severe cardiopulmonary diseases and lung infections.

AI & Machine LearningBiotechDeep TechHealthtechMedical DevicesWaltham, US

EHElizabeth Holmberg(CFO and Treasurer)Basil Athenson(Chief Executive Officer and President)BABill Athenson(Chief Executive Officer)inGKGordon Kinder(Chief Financial Officer)Philip Silkoff(Chief Medical Officer)David Zapol(Director)

Co-investorsSASaturn PartnersUNUnorthodox Ventures

FocalCool develops therapeutic hypothermia technology for treating medical conditions through targeted cooling interventions.

BiotechDeep TechHealthtechMedical Devices

Tom Merrill(Co-Founder & CEO)inJennifer Mitchell(Co-Founder & Technical Advisor)inJay Yadav(former Chairman and Co-Founder)in

TRIM-edicine is a biotechnology company developing biopharmaceutical products based on protein and peptide biology for tissue repair, regenerative medicine, age-related dysfunction, and oncology.

BiotechHealthtechLongevityMedical Devices

Unique Mobility Devices develops patented "zero-lifting" mobility devices, the SitAssist One and SitAssist Two, that lift and transfer people from the floor in seated or supine positions without slings or hoists.

HardwareHealthtechMedical DevicesTucson, US

Venebio Group provides data and technology-driven consulting services to pharmaceutical companies, biotechnology firms, medical device manufacturers, and law firms, delivering scientific manuscripts, regulatory submissions, and related documentation.

BiotechData & InfrastructureDigital HealthEnterprise SoftwareHealthtech

Veralase makes portable lasers for research and development use, including handheld, tunable fiber-coupled, and clinical laser models with configurable wavelengths (808 nm to 1550 nm) and power outputs.

Deep TechHardwareMedical Devices

Veriskin makes a handheld, AI-powered medical device that assesses suspect skin growths by imaging cutaneous blood flow in real time, delivering results in about two minutes.

AI & Machine LearningBiotechHealthtechMedical DevicesSan Diego, US

MCMirianas Chachisvilis(Executive Officer, Director)inKHKevin Herzberg(Director)inJohn Fitzgibbon(Director)Eugene Tu(Director)Carl Edman(Director)

Co-investorsARArieal Southeast Angel PartnersPAPasadena Angels

ViewPlus manufactures braille embossers and tactile graphics hardware and software to make educational and technical information accessible to blind and visually impaired students and professionals.

EdTechHardwareHealthtechCorvallis, US

John Gardner(Founder)Carolyn Gardner(Co-founder)Dan GardnerSusannah Gardner

VirTech Bio develops OxyBridge, a human-derived hemoglobin-based oxygen carrier (HBOC) intended as a blood substitute for time-critical trauma patients in hemorrhagic shock and for pre-transplant donor organ perfusion.

BiotechHealthtechMedical DevicesBeverly, US

Joseph Tucker(Executive Officer)MVMatias Vidal(Co-Founder & Executive Chairman)inDHDallas Hack(CEO & Director, Medical Affairs)inCDCOL(R) Dallas Hack, MD, MPH(CEO & Director, Medical Affairs)in

A biologics center of excellence focused on developing and delivering medicines to patients, operating as a subsidiary within the Otsuka pharmaceutical group.

AI & Machine LearningBiotechHealthtechMedical Devices

Zachary Shriver(President and Chief Executive Officer)KVKarthik Viswanathan(Vice President, Research)in

Co-investorsCTCTI Life Sciences Fund L.P.CYCycad Group LLCLULux CapitalMRMRL Ventures Fund

Las Vegas, US

Stephen J. McCormack(Executive Officer, Director, Promoter)

BoardJohn R. Kimberly(Director)John Wyatt(Director)

Vivonics develops mobile physiological monitoring devices, advanced diagnostics, and non-invasive clinical decision support technologies focused on improving human health and wellness.

AI & Machine LearningDeep TechDigital HealthHealthtechMedical Devices

Gordon Hirschman(President and CEO)Michele Pierro(Director of Technology Development)Michael Martell(Director of Business Operations)

Waldron International develops software systems for information management and organization.

Data & InfrastructureEnterprise SoftwareHealthtechMental HealthSaaS

Microbiome analysis company using lab science and machine learning to identify markers and interventions.

BiotechSan Francisco, US

John S. Eid, Ph.D.(Executive Officer, Director)CCColleen Cutliffe(Executive Officer, Director)James H. Bullard, Ph.D.(Executive Officer)OKOrville Kolterman, M.D.(Executive Officer)

BoardADAdam D'Augelli(Director)inPeter Barton Hutt(Director)

Co-investorsB3B3 HoldingAMAME Cloud VenturesKHKhosla VenturesSESequoia CapitalTRTrue Ventures

Xenex builds pulsed Xenon UV light disinfection robots that deactivate pathogens missed during manual cleaning, used by hospitals to reduce environmental contamination and healthcare-associated infections.

HealthtechMedical DevicesRoboticsSan Antonio, US

M(Mark (Tuck) Stibich(Co-founder)JSJulie Stachowiak(Co-founder)MMMorris Miller(CEO)inMark "Tuck" Stibich, MHS PHD FIDSA(Founder, Chief Scientific Officer)

Co-investorsBABattery VenturesTATargeted Technology FundsTETectonic VenturesESEssex Woodlands Healthcare Partners

Xona Microfluidics develops microfluidic chip technology for neuroscience research and drug screening applications.

BiotechDeep TechHardwareMedical Devices

Anne Taylor(Chief Scientific Officer & co-founder)Brad Taylor(CEO & co-founder)

Xoran develops point-of-care CT imaging systems and related software for hospitals, clinics, and veterinary practices.

AI & Machine LearningHardwareHealthtechMedical DevicesAnn Arbor, US

Ziteo Medical is developing a handheld, miniaturized intraoperative molecular imaging device that combines molecular imaging, computer vision, and augmented reality to help surgeons locate and remove cancerous tissue.

AI & Machine LearningHealthtechMedical DevicesBerkeley, US