Casdin Capital — 2021 Investments

Century Therapeutics develops allogeneic, iPSC-derived cell therapies using gene editing and protein engineering for autoimmune diseases including type 1 diabetes and cancer.

AI & Machine LearningBiotechHealthtechMedical DevicesPhiladelphia, US

Osvaldo Flores, Ph.D.(Executive Officer, Director)Douglas Carr(Executive Officer)inBPBrent Pfeiffenberger(President and Chief Executive Officer)inGregory Russotti(Chief Technology and Manufacturing Officer)CCChad Cowan(Chief Scientific Officer)in

BoardToshikazu Ban(Director)

Board seatECEli Casdin· per SEC Form D

Co-investorsLILifeSci Venture PartnersRARA CapitalVEVersant Ventures

Prime Medicine develops one-time genetic therapies using Prime Editing, a gene editing technology developed in David R.

BiotechDeep TechHealthtechMedical Devices

AAAndrew Anzalone(Founder)inDLDavid Liu(Co-founder)inARAllan Reine(Chief Executive Officer)inMAMohammed Asmal(Chief Medical Officer)inALAnn Lee(Chief Technical Officer)inSMSvetlana Makhni(Chief Financial Officer)in

Co-investorsARARCH Venture PartnersGVGV (Google Ventures)NENewpath PartnersF-F-Prime CapitalOUOUP (Osage University Partners)SASamsara BioCapital+1 more

C2i Genomics develops a whole-genome sequencing platform that uses AI algorithms to build patient-specific cancer signatures for detecting minimal residual disease (MRD) and monitoring cancer.

AI & Machine LearningBiotechDigital HealthHealthtechNew York, US

AZAsaf Zviran(Founder)inEzra Sofer(Executive Officer, Director)

BoardAPAlex Parker(Director)SRShaun Rodriguez(Director)in

Board seatECEli Casdin· per SEC Form D

Co-investorsIGiGlobe PartnersLILionBirdNANat TurnerNFNFXSESection 32

Genomatica (Geno) develops biotechnology processes to produce bio-based chemicals and materials—such as 1,4-butanediol (BDO), butylene glycol for cosmetics, and plant-based nylon—as alternatives to fossil-fuel-derived inputs.

BiotechCircular EconomyCleantechClimate TechNew MaterialsSan Diego, US

CSChristophe Schilling(Co-founder (former CEO))inBernhard Palsson(Co-founder)Carlos A. Cabrera(Executive Chairman)inJGJohn G. Gugel(Chief Executive Officer)inTMTom McDonald(SVP, Finance & Chief Financial Officer)inNBNelson Barton(SVP, Research and Development)in

Board seatECEli Casdin· per SEC Form D · $119.1M raise · filed Aug 2021

Co-investorsTHThule InvestmentsVAVantagePoint Capital PartnersVIViking GlobalDRDraper Fisher Jurvetson (DFJ)MOMohr Davidow VenturesNONovo Holdings

SomaLogic develops proteomics tools that help researchers measure protein function and study human biology across a range of scientific applications.

BiotechDeep TechHealthtechBoulder, US

LGLarry Gold(Founder)inDaniel Muehl(Executive Officer)BHByron Hewett(Executive Officer, Director)in

BoardCharles Lillis(Director)Youichi Yabuuchi(Director)Terry Randall(Director)

Board seatECEli Casdin· per SEC Form D

Co-investorsFOForesite CapitalKHKhosla VenturesMAMagnetar CapitalREReimagined VenturesSOSoleus CapitalT.T. Rowe Price

Biopharmaceutical company discovering and developing novel biologics, protein, and peptide therapeutics.

BiotechSouth San Francisco, US

Trisha Millican(Director)James Topper(Director)Otello Stampacchia(Director)David Hirsch(Director)Volker Schellenberger(Executive Officer)James Brush(Director)

Co-investorsBABain Capital Life SciencesFRFrazier Life SciencesLOLongitude CapitalVIViking GlobalBLBlackRockFRFranklin Templeton+6 more

Beacon Biosignals develops AI-powered EEG analytics technology to improve diagnosis and treatment of neurological, psychiatric, and sleep disorders.

AI & Machine LearningBiotechDigital HealthMedical DevicesBoston, US

Jacob A. Donoghue, M.D., Ph.D.(Executive Officer, Director)JDJacob Donoghue(CEO & Co-Founder)inJRJarrett Revels(CTO & Co-Founder)in

BoardCaitlin Donovan(Director)Pavel Raifeld(Director)NRNaveen Rao(Director)in

Co-investorsGEGeneral CatalystALAlumni VenturesCACatalio Capital Management, LPGVGV (Google Ventures)HAHalf Court VenturesIAIaso Ventures+5 more

Exo Therapeutics is a small molecule drug discovery company developing therapeutics through its ExoSight platform, which targets exosites—unique binding pockets on enzymes—to address previously undruggable diseases in oncology, inflammation, and other therapeutic areas.

BiotechDeep TechMedical Devices

David Liu, PhD(Founder)ASAlan Saghatelian, PhD(Co-Founder)DLDavid LiuinASAlan Saghetelian

Co-investorsNENewpath PartnersCRCRV (Charles River Ventures)NENextech InvestRARaptor GroupSASamsara BioCapitalBIBiotechnology Value Fund+1 more

Formation Bio develops drugs through partnerships with health systems, academic medical centers, and research sites, focusing on clinical trials in dermatology, rheumatology, and cardiometabolic diseases.

AI & Machine LearningBiotechDeep TechDigital HealthHealthtechMedical DevicesSaaSNew York, US

BLBen Liu(CEO & Co-Founder)inLZLinhao Zhang(Co-Founder)inBenjamine Liu(Founder)Kit Dobyns(Founder)Mary Rozenman(Founder)

BoardALAlfred Lin(Director)in

Co-investorsANAndreessen HorowitzSESequoia CapitalSASam AltmanSESection 32THThrive CapitalFEFelicis Ventures+11 more

Genome Medical provides telehealth-enabled genetic services, including genetic counseling, genetic testing, and clinical trial matching, with a focus on individuals with rare conditions.

BiotechDigital HealthHealthtechSouth San Francisco, US

LALisa Alderson(Executive Officer, Director)inRandal Scott(Director)Jill Davies(Executive Officer, Director)inEMElizabeth Moreno(Executive Officer)inMSMark Sylvester(Chief Financial Officer)inAWAndrew Warner(Vice President, Product)in

Co-investorsALAlumni VenturesAVAvestria VenturesCACanaan PartnersDRDreamers VCECEcho Health VenturesGVGV (Google Ventures)+11 more

Hexagon Bio develops novel payload mechanisms for antibody-drug conjugates (ADCs) aimed at overcoming resistance to current cancer treatments and expanding ADC indications.

BiotechDeep TechHealthtechMenlo Park, US

CJColin James Bell Harvey(Director)BTBrian T. Naughton(Director)inMHMaureen Hillenmeyer(CEO & Co-Founder)in

BoardAlex Kolich(Director)

Co-investorsATATEL VenturesB3B3 HoldingNENextech InvestSOSoftBank Vision FundTHThe Column Group8V8VC+1 more

Komodo integrates healthcare data across providers, health systems, care settings, and payers to deliver insights on disease incidence, treatment patterns, and health outcomes.

AI & Machine LearningData & InfrastructureHealthtechSan Francisco, US

WSWeb Sun(Founder)inANArif Nathoo(Founder)in

Co-investorsANAndreessen HorowitzCOCoatue ManagementFEFelicis VenturesICICONIQMCMcKesson VenturesNZNZ Growth Capital Partners+7 more

Mnemo Therapeutics is a Paris-based clinical-stage biotech developing cell therapies using its EnfiniT epigenetic antigen discovery platform to target tumor-specific antigens for CAR-T therapies.

Co-investorsSOSofinnova PartnersALAlexandriaREREDMILE

Multiply Labs builds robotic systems that automate biologics manufacturing for pharmaceutical companies.

Advanced ManufacturingBiotechDeep TechRoboticsSan Francisco, US

FPFred Parietti(CEO)inAMAlice Melocchi(CSO)inNJNaveen Jain(Investor)inJoe Wilson(COO)Tiffany Kuo(Head of Marketing and Operations)Zack Bright(Lead Robotics Engineer)

Co-investorsFIFifty YearsGAGarage CapitalJUJude GomilaLILingottoP1P101 VenturesSTStrange Ventures+16 more

Nomic offers an end-to-end protein profiling service built on its nELISA technology, quantifying up to 1000 informative proteins with absolute quantification for research studies.

BiotechDeep TechHealthtechMedical DevicesMontreal, CA

MDMilad Dagher(Founder)inJMJeff Munzar(Founder)inElisha Krauss(Operations Manager)Ani Muradyan(Recruiter)

Co-investorsAMAmplitude Venture CapitalAVAvant BioFIFirst Star VenturesFRFront Row VenturesRARaptor GroupY Y Combinator+9 more

Boston-based biotech developing drugs against the 'dark genome'/repeatome for autoimmune disease, cancer and neurodegeneration.

Benjamin Greenbaum(Founder)David Ting(Founder)Rosana Kapeller(Founder)

Co-investorsANAndreessen HorowitzARARCH Venture PartnersGVGV (Google Ventures)LULuma GroupSASanofi VenturesABAbingworth+11 more

Sonoma Biotherapeutics develops engineered regulatory T cell therapies to treat autoimmune and inflammatory diseases.

BiotechHealthtechMedical DevicesSouth San Francisco, US

JBJeffrey Bluestone(Founder)inJBJeff Bluestone, PhD(Founder and Scientific Advisor; co-founder and former President and CEO)QTQizhi Tang, PhD(Founder and Scientific Advisor)FRFred Ramsdell, PhD(Founder and Scientific Advisor)ARAlexander Rudensky, PhD(Founder and Scientific Advisor)Stephen Dilly, MBBS, PhD(President and Chief Executive Officer)

Co-investors8V8VCARARCH Venture PartnersFRFrazier Life SciencesGVGV (Google Ventures)JDJDRF T1D FundLALAV+6 more

Vanqua Bio is a biotechnology company developing molecules intended to become medicines for neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, and related neurological conditions.

BiotechDeep TechHealthtechLongevityChicago, US

Rand Sutherland(Director)inJSJim Sullivan(CEO)inKHKevin Hunt(CSO)in

BoardJSJonathan Silverstein(Director)inBernard Davitian(Director)Uya Chuluunbaatar(Director)

Co-investorsAVAvoro Capital AdvisorsOROrbiMedOUOUP (Osage University Partners)POPontifax Venture CapitalOMOmega Funds

Cambridge, MA biotech developing single-course in vivo base editing medicines to permanently lower cardiovascular disease risk.

BiotechCambridge, US

Andrew Ashe(Executive Officer)SKSekar Kathiresan(Founder)inABAndrew Bellinger(Executive Officer)Kiran Musunuru(Founder)

BoardJohn Evans(Director)APAnthony Philippakis(Director)in

Co-investorsARARCH Venture PartnersF-F-Prime CapitalGVGV (Google Ventures)RARA CapitalVEvenBio PartnersWEWellington Management+3 more